LOCUS       NZ_CP042828            21158 bp    DNA     circular CON 27-APR-2024
DEFINITION  Ruania zhangjianzhongii strain HY168 chromosome, complete genome.
ACCESSION   NZ_CP042828
VERSION     NZ_CP042828.1
KEYWORDS    RefSeq.
SOURCE      Ruania zhangjianzhongii
  ORGANISM  Ruania zhangjianzhongii
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Ruaniaceae;
            Ruania.
REFERENCE   1  (bases 1 to 5067305)
  AUTHORS   Huang,Y.
  TITLE     Ruania sp. HY168
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5067305)
  AUTHORS   Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-AUG-2019) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, Changping, Beijing 102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 178.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008000995.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:28:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,709
            CDSs (total)                      :: 4,654
            Genes (coding)                    :: 4,621
            CDSs (with protein)               :: 4,621
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 33
            CDSs (without protein)            :: 33
            Pseudo Genes (ambiguous residues) :: 0 of 33
            Pseudo Genes (frameshifted)       :: 13 of 33
            Pseudo Genes (incomplete)         :: 20 of 33
            Pseudo Genes (internal stop)      :: 1 of 33
            Pseudo Genes (multiple problems)  :: 1 of 33
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:19:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3260265
            Orig. end                         :: 3281423
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP042828.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21158
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="6"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21158
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21158
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11158](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11158)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(37..1113)
                     /locus_tag="FU260_RS15225"
     CDS             complement(37..1113)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015881851.1"
                     /locus_tag="FU260_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_147917834.1"
                     /transl_table=11
                     /translation="MNDNAPAGVAAGGGAASSPPGDQAPAPAGGSAGRRFLKSLGGGGG
                     RGRMLGLIVALILICLVGAITAGDRFVDTANVLTILRAAAVLGVVSIGVTFVITAGGID
                     LSVGSVLGLASVWATTLATQRMAEDTHWLVMVFTAAAVGTAAGLVNGLIVAYGKVVSFI
                     ATLAMLIAARGLAEIISGRRTQLVTDSGFEGFFDGNFLGVPTIVWIFAIVAAIAWVLLN
                     RTTFGRRTVAVGGNAEAARLAGINIKRHLVYVFALSGFTAGIAAVMMMGRTGAGTSTHG
                     MLLELDAIAAVVVGGTLLIGGRGTIIGTVIGVLIFTTLENVFVLNNLSTSVQALVQGGI
                     IVVAVLLQQRFAVRGTSP"
     gene            complement(1106..2626)
                     /locus_tag="FU260_RS15230"
     CDS             complement(1106..2626)
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020017542.1"
                     /locus_tag="FU260_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_147917835.1"
                     /transl_table=11
                     /translation="MVTVDPLKPILTITNLIKHFPGAKALDGVDFDVREGEVHCLLGQN
                     GAGKSTLIKVLAGAHQPNAGEIRWQGDVVKIASPLAALDLGIATMYQELDVVDGLTVAE
                     NIYLGHELSRGGVLRFAEAQERTRALLRRLGHPEIPPGRDVGQLSAAGKQIVSMARALS
                     HDAKVIVMDEPSAVLDPEEVDKLFQVVRMLTAEGVAVIYISHRLEEIRSIGDRITVLKD
                     GETVASGLAVADTPTADLIQLMTGRRVETDFGGSGVAEPGDVVLDVDGLALAGVFEDVS
                     FQVRAGQIIGLAGLVGAGRSEIVETIYGARPASAGTVRVNGKRVRPGSVPSAVSRGIGL
                     APEERKSQGLLLDEPVYRNITLSSFARFARGSFLDERAERKAAREQMEALHLVPADPDR
                     PGRTFSGGNQQKAMLARWLVHGCDVLLLDEPTRGVDVGARAEIYGLIRELARQGTAIVV
                     VSSEIEEVLGLADQVFVIAEGAVVHHGPADQIDEHGVLDLVMEGTAHE"
     misc_feature    2643..2655
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.62"
                     /tool="antismash"
     misc_feature    complement(2738..2756)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.7"
                     /tool="antismash"
     gene            2784..3977
                     /locus_tag="FU260_RS15235"
     CDS             2784..3977
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018770298.1"
                     /locus_tag="FU260_RS15235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ROK family protein"
                     /protein_id="WP_235912481.1"
                     /transl_table=11
                     /translation="MSEPKGSRDSDPRSAGILFQYVRDGQPRTRADIVAATGFARPTVA
                     ARIDELERVGLIVPTGEASSTGGRPPATFAFNPGVRLILVADLGVRHGRLAITDLAARV
                     LSERSVEITISDGPESVLDTVVAEFLEMLEAFGRPLDEVLGVGVGLPGPVEHHAGRPIS
                     PPIMPGWDGFDVPAYLQRQIPAPILVDNDVNIMALGEHRAYWQDVQDLIYVKVATGIGA
                     GIITDGELRRGAQGAAGDLGHIAVPQGRQVPCRCGNIGCLEALASGYAVVESLREQGYD
                     IQWADQIVDLVRHGDTNVMQTVRHAGRDIGQVLASGVNLLNPTVIVIGGQVANVGEHLL
                     AGIREVVYSRSLPLATQHLRIVVSKAGGQAGVLGAAQMVIQQVLAAPAIDRLVGSAD"
     gene            complement(4002..4697)
                     /locus_tag="FU260_RS15240"
     CDS             complement(4002..4697)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018178.4"
                     /locus_tag="FU260_RS15240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1080 domain-containing protein"
                     /protein_id="WP_147917836.1"
                     /transl_table=11
                     /translation="MPRRAGDGRRRVRDVLGAFVALLIMTVPACAPAEAPECAAGLHES
                     GYRVLFDGSRVSLEQWQMTGPGAFELSAECSMVTRGGMGLLWFPEEFEDYILRLDWAIT
                     DDDNSGVFVGFPDPGHEVWTAVNEGYEVQIDPSDAPDRTTGSIYTFQGADAQARDRAVN
                     PAGDWNTYRIAVRDGRIRVHLNGVLVNEFTSDQPDRDLDSGHIGLQNHGEDDVVRFRNV
                     QILELARSE"
     gene            complement(4828..9696)
                     /locus_tag="FU260_RS15245"
     CDS             complement(4828..9696)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019607.4"
                     /locus_tag="FU260_RS15245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_168211789.1"
                     /transl_table=11
                     /translation="MSGASAHPGHDDAGATAAVQADAPEGVDWSDYEKLLLTKDTGEPI
                     DLAVLPDSRVLHTARDGVLRLTDPTSGLTSQVAELDVYHNSEDGLQGIALDPNFEENHW
                     VYMAYAPREMSGTSATGVDYPQTTPSGSAPEQLPEGADPETYWDQWLGYNVLSRFQFDP
                     ETGNLDLDSEQQIIKIDAQRGQCCHVGADIAFDGDGNLYLSTGDNTPAGTPGANGYTPI
                     NNAPGMNPGFDSRRGSGNTNDLRGSILRINVLDDIASGAEPGPESTYTIPEGNLFNTGE
                     YDAELVREEIYVTGVRNPFRIDFDTESGALVWGDYGPDAGSAQADRGPMGYVEWQLTTE
                     PMNGGWPYCHGPNDGGAYNEWNFEDGVAGDVTFDCATGPVNNSTFNTGLEQLPPVTEPQ
                     IWYGDEPGDQPEAWDGLVSFTDGGGQAPMGGPIYRYDAENESTTQFPEVWDGHAFMAEF
                     SQDYVAAFGLDELSSDGEVTDIYNFLPNAHLYEQAVPEWSGIMDMEFGPDGSLYVLEYG
                     KGFFRQNPEAGIYRIDYNPNNKTPRAVLEADQISSSDAPLEVQFDASASVDPEAENVTY
                     EWDFEGDGEFVEGEAVESFTYDELGQYTAVVRVTDPQGLFGLAVQEITVGNTAPEIELN
                     VDNGAIFNWGDSVDISVSVTDAEDGNEPVCDRVNWTFGLGHNLHAHPEVSGTGCEFTLE
                     TSENAVEHGEGEKIFGTLVVSYTDEAQGDVPATTGEATLVLKPEVQQAEWYDSAEGVSV
                     ADDPDASAGSYVTEFEEGDSITFEPVALTHAPSGEPIDTVTARGSGEGTLSLNWQDETL
                     ASFDFSGDTGWQDVTAALEQAPEGSGAVVVTSTGGVDLDALTFAASGDSGSEPPVCEDP
                     EADVPADDEFDGTQVDPCRWEIVDYDSDLAHVSDGSYHVSTTDADFYGTDNSPVPNILQ
                     SKVLSGDQWTVEAAFTADLESSYQQGGIMVRADEDNYVKIDPVYAGDGGDTPLRVELRS
                     EVNGEVQDPQDDLTDLALPTDGTYHVQLTRDGDTFTGAFSTDGEDWQELPSAVTNASLA
                     DAAPGLYALGAQQAEPTTVSFDYFRVVDGEESPEPIEVPVEDVSLQMFSLIPWVDEVGL
                     EAVLERLGEIGFVNIEPFGGNFEGYTAQEFRELAAGYGLSVPSSHYNVDEDSFGETLEF
                     VDTLGQEYVGSGGFAAPGIDTYEDTLATAETMNRLGQLSVAAGVGKFFGHNHDGEFTTM
                     YEHEGEQLSAWEILVAETNPEYVTFELDVAWAAHAGVDVVELIGTYGDRVELLHIKDAT
                     DLGGADGPTFTNLGEGEMALQEILAAAQEAPIAYYALEYDMAGDGESFATSGFEYLTGI
                     EAGQPEPEEPVQVTPEEVTFTDEPGTDSDSFVVPEVEGVQYLAGGDVIEAGTHPGEGTV
                     TVTAQAVEGYELAEGATVEWSHTFDATGGPGELVEVTPEEVVFTDEPGTENDAFTIPEV
                     EGVEYVLLGESAGGSPGVAGSRSVLARDIAAALVPTPDEVLEPGTYAAQGSVTIIARAA
                     AGYVLPEGATTEWTFEFSTAGQEAPTDPGADPTDPGADPTGPGADPTGPGQDPTGSGEV
                     PTEGSTGGDLPTTGADVGVLAALAALLLLVGTGIATRARRQHA"
     gene            complement(10001..11158)
                     /locus_tag="FU260_RS15250"
     CDS             complement(10001..11158)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="FU260_RS15250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_147917838.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.5e-38, bitscore:
                     130.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERPEQLEAERSVAESGRGDPSAAVAEVLREVVAQEWRQAAGHG
                     RPYELLWRHLEQAISGGKHFRGRLVIETYTGLCGKDLPAAARLGAAFELLHAGFLVHDD
                     LIDHDTLRRGHPNLAAGMSSAATAEGADTTTAEHLAEASAVLAGDLAIALAHRLTATVE
                     APVAVRTVLADLLWRTVFVSVAGELGDVAAAHGLWEVSAEQALTTAAEKTAFYSFQAPL
                     RAGAVLAQAPDDVQEPLDRVGQALGKAFQLADDLLGVFAPEAVTGKSQLSDLREGKATT
                     LMLYARELPVWDRIGSAVGRADLDVAAADLIRRELGASDAPARVDAQARHELVLARRCL
                     LTTPGLEPVIDVVMPAWSMVADQLDMAIRYAAALGARDIKDQAGA"
     misc_feature    11212..11228
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.42"
                     /tool="antismash"
     gene            11308..12501
                     /locus_tag="FU260_RS15255"
     CDS             11308..12501
                     /GO_function="GO:0004512 - inositol-3-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006021 - inositol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141908.1"
                     /locus_tag="FU260_RS15255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="inositol-3-phosphate synthase"
                     /protein_id="WP_147917839.1"
                     /transl_table=11
                     /translation="MSTSPGEKATARDGSQVRTGIWFIGARGSVATTATIGSLAVAAGL
                     ADRTGLVSELAPIAAATAPIEIGSLVTGGHDVADTPLPERAMALAESGVFPFALAAALR
                     DELAEADKRIKSAPRRATQRETASAIADDLHSFREEHGLARVVVVDVSNTEAPVQPGPE
                     LNDLATLEEALDAGRSPLPQSSLYAYAAFRAGCALVAFTPSPGPNLPALVELAQRQSVP
                     WAGRDGKTGETLVKTTLAPMFATRALKVRSWASYNLLGGGDGQTLADPDAAMSKTATKG
                     AGVDAILGHHVDGPLRIDYVEDLGDWKTAWDHVSFEGFLGTRMTMQFTWQGCDSALAAP
                     LVLDLVRLVARAHETGEVGVIGAMAFFFKEPLGGEEHALSGQWQALSEWCEKLAIAR"
     gene            12498..13367
                     /locus_tag="FU260_RS15260"
     CDS             12498..13367
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141909.1"
                     /locus_tag="FU260_RS15260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SCO3242 family prenyltransferase"
                     /protein_id="WP_147917840.1"
                     /transl_table=11
                     /translation="MTALRDLIELTRLPAALTVPGDTLAGAAAAGSLPSWRAAPLAASS
                     ACLYWAGMALNDYADRELDAQERPERPIPSGRVSPSTALRLAGGLTLAGLTLAATAGPR
                     PLAVALPLAGAVWTYDLIAKPTVAGPLVMGTTRFLDVLMGGTANPRRALPAALALGVHT
                     TAVTVLSRGEVHGTSTRTATATVATTGVVASAAAIQSLRDTSQPPAARIAGAALAGTYA
                     SAVGQTQGDAVARPDPATVRRATRRGIHGMVPLQASLIARRGHLGIAAGLLALGPLLRA
                     AAKVVSPT"
     gene            13364..14236
                     /locus_tag="FU260_RS15265"
     CDS             13364..14236
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141910.1"
                     /locus_tag="FU260_RS15265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_147917841.1"
                     /transl_table=11
                     /translation="MTLRLSYGTNGFGDHRLSDALAIIADLGYDGVALTLDHHHLDPFA
                     VDVATQVGTIDRLLTTHGLAVVIETGARYLLDPRRKHEPTLVSAHGRELRLDFLHRAID
                     IAADLGSDIVHFWSGTLPAGTSIDTGWDRLLTGMAEILPHAESAGVRLAVEPEPGMLIE
                     RLADAQELRMRLGSPDALRLTLDVGHALCNEDLTPDAAIRAAAGDLIHVQIEDMRRGVH
                     EHLEFGDGELDLDRSVEALLEVRYAGLVSVELARHSHAAPVTAARSIDALRTAVASCES
                     RLATTQEPR"
     gene            14233..14919
                     /locus_tag="FU260_RS15270"
     CDS             14233..14919
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF035938.1"
                     /locus_tag="FU260_RS15270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EboA domain-containing protein"
                     /protein_id="WP_147917842.1"
                     /transl_table=11
                     /translation="MTERYHAILADRLSPQAQDRLHQMTTAIGEKPAAIAVLFPAAARE
                     VGRGPVDEGDPGGVLGPTLDDIVRGVLLLALAEAEPDPSDLLRHVGQLYRFGDSEERRA
                     VLRALADLGLGQPAQYLVEDALRSNDVRLIGAAMGDWAGAHLEDAAWRQGVLKCLFVGV
                     PLAAVARLTDRADAELARMVAAFAHERLAAGRTIPPDAHPILDLFPGSLEQFPDVGAAL
                     DSASSP"
     misc_feature    14608..14610
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14941..15807
                     /locus_tag="FU260_RS15275"
     CDS             14941..15807
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141912.1"
                     /locus_tag="FU260_RS15275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TatD family hydrolase"
                     /protein_id="WP_147917843.1"
                     /transl_table=11
                     /translation="MRIFDPHIHMTSRTTDDYQNMREAGVQALVEPAFWLGQPRTSVES
                     FIDYFDALIGWERFRSAQFGIAHHATIALNPKEANDPRCAEVLDLLPRYLAKDGVVAVG
                     EVGFDSMTDAEEHAFGRQLELAIEHGLPAMVHTPHRDKAAGTRRTLDLVREVGIDPGMV
                     VVDHLNETTVDMVSDSACWMGFSIYPDTKMDPGRMVAILAQHGLDRVMVNSAADWGHSN
                     PLSTLRTGEAMLAAGFSDDDVDRVLWRNPVEFFAQSGRLMLEDNASDGATFEGNSIQRG
                     ERKAQDA"
     gene            15812..16990
                     /gene="eboE"
                     /locus_tag="FU260_RS15280"
     CDS             15812..16990
                     /codon_start=1
                     /gene="eboE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141913.1"
                     /locus_tag="FU260_RS15280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metabolite traffic protein EboE"
                     /protein_id="WP_147917844.1"
                     /transl_table=11
                     /translation="MRLRHPDGTLVHLAYCSNVHPAEDPAGIHEQLRRFAGPVRERLGV
                     QRLGLGLWLPAATAALLASDEGELAALRAVLDEQGLEVVTLNAFPYRGFHDPVVKHRVY
                     SPDWTERARLTYTLDAAKVLTSLLPDDVRRGSISTLPLAWHTAWSPEARSAARANLDEL
                     AAGLARLQESTGRQVRVGFEPEPGCVIETTTQAAEELAGVDTDYLGVCLDTCHLATAFE
                     DADDAVARLTAAGLPVVKSQLSAALHVPDPAAASGVLGTFVEDRFLHQVRETGPDGRLL
                     ARDDLPEALGGEALGSEPLPGKRPWRVHFHMPLHAAPQPPLVNTDDELFAAARALLGGK
                     HALTDHLEVETYTWSVLPAEARPTDDAGLIAGLAAELAHARGHLHALGLEDV"
     gene            16987..18366
                     /locus_tag="FU260_RS15285"
     CDS             16987..18366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020013660.1"
                     /locus_tag="FU260_RS15285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotide pyrophosphatase/phosphodiesterase
                     family protein"
                     /protein_id="WP_147917845.1"
                     /transl_table=11
                     /translation="MSKLLVLNVVALTPRILEHMPRLKKVAQSGYQATLETVLPAVTCS
                     AQSTYLTGKTPGEHGIVANGWLFRDLGDILLWRQHNGLVAGERVWETIRRTRPEYTVAN
                     VCWWYAMGATVDATVTPRPAYYADGRKEPDCWTWPPSLHDSLVSELGPFPLFTFWGPGA
                     SIDSSRWIIGATRRLMPEHDLTLAYVPHLDYDLQRFGPSGPEAVRAAQELDEALAPLLD
                     DAEALGATVVVLSEYGITDVSRAVDVNRVLRRAGLLHVHHNETGELLDTWTSPAFAVAD
                     HQVAHVYVRNEENLPQVKALLEEVPGVAQVLDAEGKRAHGLDHARAGELVLVAEPDSWF
                     TYYYWLDDANAPDFAKLVEIHKKPGYDPVELFMDPEDRWVKLRAATAVARKKLGMRYKL
                     DVVPLDPAPIRGSHGRLPDDPSEGPVLLCSDAENARDLVGATEVRDLLLDLVGVPAPRV
                     G"
     gene            18475..19662
                     /locus_tag="FU260_RS15290"
     CDS             18475..19662
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013771899.1"
                     /locus_tag="FU260_RS15290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ROK family protein"
                     /protein_id="WP_235912444.1"
                     /transl_table=11
                     /translation="MAVSPTSRTTGPGELLQILRDGAPRARADLVAVTGHARTTIGSRI
                     DALLRTGLVRTEAASSTGGRPPSVYVFDPGARVVLAVDLGAVHLSVAVLDLAGTVLAEE
                     RTVCDIAEGPDPVLAHVNELGQQLLDRLGRPATDLAGVGIGVPGPVQQTTGRPITPPIM
                     PHWDGVDIKGILGRQFGVPVLVDNDVDLMALGEHGAVYPEVSHLLFVKVATGIGAGIIA
                     NRTLVRGTDGAAGDLGHVAVPGGRAELCHCGNSGCLEAVASGGALVRALRAAGEEVATS
                     ADVVDLVRRGDQRATALLRDAGRDLGAVLAGCVNLLNPSAIVIGGVLAQAGEHLLAGAR
                     EVVYRRSLPLATKQLRIVTASTAGRAGLLGAGRVVADHVLAPAAVDALAAAQTPV"
     gene            complement(19899..20867)
                     /locus_tag="FU260_RS15295"
     CDS             complement(19899..20867)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FU260_RS15295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="type IV toxin-antitoxin system AbiEi family
                     antitoxin domain-containing protein"
                     /protein_id="WP_147917846.1"
                     /transl_table=11
                     /translation="MPALPFDTHGLVTSADATRAGMRAVLQGMVASGKLERLWPGVYRR
                     PLSIGTPAERAAEAYRARVLAAARRLRRPVFASYSAAALLGLPIIGTWPDEIFILSGRA
                     TGSRQGRLVRLATRCDPPLMENGDLRITSVAYTLIQLARQARLGAAVVAADAALRDLPY
                     GPKAAPLTTLTELMAMHQRLLPYPRSNRVQAMLDRATHLSASALESVSRLAIEELGLAT
                     PQLQVRLHLDAPHGDVYLDFGWEQDIGGESDGDSKYLAPDNTVATAARLLAEKEREDAM
                     RAKLRGLARWGWRDAWQGSPLRRKLLQVGVPQVRSSVARFW"
ORIGIN
        1 gcccgggctg ggcgggcaag tgggaggtgg atgaggtcat ggggaggtgc cccggaccgc
       61 gaagcgctgc tgcagaagga ccgccaccac gatgatcccg ccctggacca acgcctgcac
      121 cgaggtggac aggttgttca ggacgaagac gttctccagg gtggtgaaga tcagcacgcc
      181 gatcaccgtg ccgatgatcg tgcctcgccc gccgatcagc agggtgccac cgacgaccac
      241 tgcggcgatg gcgtcgagct cgagcagcat gccgtgggtc gaggtgccgg caccggtgcg
      301 ccccatcatc atcaccgccg cgatcccggc cgtgaatccg gacagagcaa agacgtagac
      361 gaggtgccgc ttgatgttga tgcccgccag gcgggccgcc tcggcgttcc cacccaccgc
      421 cacggtgcgc cgaccgaagg tggtgcgatt cagcagcacc cacgcgatcg cagccacgat
      481 cgcgaagatc cacacgatgg tcggcacgcc gaggaagttg ccgtcgaaga agccttcgaa
      541 gcctgagtcg gtgacgagct gggtacgtcg tcccgagatg atctcggcga gtccgcgggc
      601 ggcgatgagc atggccaggg tggcgatgaa ggagaccacc ttgccatagg cgacgatcag
      661 tccgttcacc agcccggcgg cggtccccac cgccgctgcg gtgaaaacca tcacgagcca
      721 gtgggtgtcc tccgccattc gctgtgtggc caaggtggtg gcccagacac tggccaggcc
      781 aaggaccgag ccgacggaca ggtcgatgcc gccggcggtg atgacgaagg tgactccgat
      841 actgaccacg cccaggacgg cggcggcgcg caggatcgtc aggacgttcg cggtgtccac
      901 gaaccggtcc ccggcggtaa tcgccccgac gagacagatc aggatcagcg cgacgatcag
      961 cccgagcatc cggccacggc cgccaccacc acccaggctc ttcaaaaacc gtcggccagc
     1021 ggatccgccc gccggcgcag gtgcctggtc gcccggtggc gaggaggcgg cgccgccacc
     1081 ggctgcgacg cctgccggcg cattgtcatt catgtgcggt tccttccatg acgaggtcga
     1141 gcacaccgtg ctcgtcgatc tgatcggcgg gcccgtggtg cactaccgca ccttcggcga
     1201 taacgaagac ctggtcggcg aggccgagga cttcctcgat ctcgctggag acgacgacga
     1261 tcgcggttcc ctggcgggcg agctctcgga tcagtccgta gatctcggca cgagcgccga
     1321 cgtcgacacc gcgcgtcggc tcgtccagca gcagaacgtc acagccgtgc accagccatc
     1381 gggcaagcat cgccttctgc tggtttcctc cggagaacgt ccggcccggc cggtcgggat
     1441 ccgccggcac caggtgcagc gcttccatct gctctcgtgc ggccttacgc tcggcccgtt
     1501 cgtcgaggaa gctgccccgg gcgaaccggg cgaaggacga cagggtgatg ttgcggtaga
     1561 ccggttcgtc gagcagcagc ccttggctct tccgctcttc cggcgccagc ccgattccgc
     1621 gggacacggc gctcggcacc gagcctggac gcactcgctt cccgttcacc cggacggtac
     1681 ccgccgaggc gggccgggcg ccgtagatgg tttcgacgat ctcggagcga ccggccccga
     1741 ccagacccgc gaggccgatg atctgccccg cccggacctg gaagctcacg tcctcgaaca
     1801 cgccggccag cgcaagcccg tccacatcca ggaccacgtc gcccggctca gccacaccgc
     1861 tgccaccaaa gtcggtctcg acgcgtcggc cggtcatcag ctggatgagg tcggcagtcg
     1921 gggtgtcggc gactgcgagg ccggaggcaa cggtctcacc gtccttgagg accgtgatcc
     1981 ggtcgccaat gctgcggatc tcctcgagcc gatgggagat gtagataacc gcgacgccct
     2041 cggcggtcag catcctcacc acctggaaga gcttgtccac ctcctccggg tcaagcaccg
     2101 ctgacggttc gtccatgacg atgactttgg cgtcgtggga gagcgcacgc gccatcgaga
     2161 cgatctgctt gccggcagcg gagagctgcc ccacgtccct gccgggtggg atctccgggt
     2221 gcccgaggcg ccgcagcagc gcacgggtgc gctcctgtgc ctcagcgaac cgcagcactc
     2281 cgccccgcga cagttcatga ccgagataga tgttctctgc caccgtcagg ccatcgacga
     2341 cgtcgagctc ctggtacatc gtggcgatgc cgagatcgag tgcggcgaga ggtgaagcga
     2401 tcttgacgac gtcgccctgc cagcggatct ccccagcgtt cggctgatgg gctccggcga
     2461 ggaccttgat gagtgtcgac ttgccggcac cgttctggcc gagcaggcag tggacttcgc
     2521 cttcgcgcac atcgaagtcc actccgtcga gagccttggc tccggggaag tgcttgatga
     2581 gattagtgat cgtgaggatg ggcttgaggg ggtctaccgt gaccatgcgc agcatcgtag
     2641 gcatgggtta tgcaactcgt caaccaaaag tcgcacaatc ttcacacgcc tacagccaga
     2701 taatcgctag aagtactcag aagtgatggt ttactggtga ggtgagcgaa accgcaatca
     2761 aggggaccca cgtcaagggg acaatcagcg agccgaaggg ctcccgcgac tcagacccgc
     2821 gttcagcagg gattctgttc cagtacgtcc gtgacggcca gccgcgcacg cgtgccgata
     2881 tcgtcgcggc caccgggttt gcccggccca ctgttgccgc acgtatcgat gagctggagc
     2941 gggtgggctt gatcgtcccc accggggagg cctcgtccac agggggacgg ccgccggcga
     3001 cgttcgcgtt caatccgggg gtgcggctca tcctggtcgc tgacctcggc gtacggcacg
     3061 gccggctggc gatcacagat ctcgcggcgc gtgtgctgag cgagcgttcg gtggagatca
     3121 ccatcagcga cggaccggag tccgtgctgg atacagtcgt cgctgagttt ctcgagatgc
     3181 tcgaggcgtt cggtcgtccg ttggatgagg tgctcggcgt cggggtagga cttcccggtc
     3241 cggtcgagca tcatgccggc cgtccgatca gtccgccgat catgcctggc tgggatgggt
     3301 tcgacgtgcc ggcttacctg cagcggcaga tcccggctcc gatcctcgtc gacaatgacg
     3361 tcaacatcat ggcgctcggt gagcaccggg cttattggca ggacgtgcag gacctgatct
     3421 acgtgaaggt cgccaccggt atcggtgcgg gcatcatcac cgacggcgag cttcgccggg
     3481 gtgctcaggg tgctgccggc gacctcggtc acatcgctgt gccgcagggc aggcaggtgc
     3541 cgtgccgctg tggcaacatc ggctgcctcg aggcactcgc gagtggctat gccgtggtcg
     3601 agtcgttgcg cgaacagggc tatgacatcc agtgggcgga ccagatcgtg gacctggtgc
     3661 gacacgggga caccaacgtg atgcagactg tgcgccacgc tggccgtgac atcggtcaag
     3721 tcctggccag tggtgtcaac ctgctcaacc cgacagtgat cgtgatcggc ggtcaggtcg
     3781 cgaacgtcgg tgagcacctg ctcgccggta tccgggaggt cgtctacagc cgatctctcc
     3841 ccctcgccac acagcacctg cggatcgtgg tctccaaggc ggggggccag gccggagttc
     3901 tcggcgccgc tcagatggtc atccagcagg tgctcgctgc accagcgatc gaccgcctgg
     3961 tcgggtccgc cgactgagct ggtccgaccc tgtcggcgcc ttcattcgga tcgggccagc
     4021 tcgaggatct gcacgttgcg gaaccggacg acgtcgtcct cgccatgatt ctgcaggccg
     4081 atgtgcccag agtcgaggtc acggtccggc tgatcgctgg tgaactcgtt gacgagcaca
     4141 ccgttgagat ggacgcggat gcgtccatcc cggacggcga tccggtaggt attccagtca
     4201 ccggccgggt tgactgcccg atctcgtgcc tgagcatcgg cgccttggaa ggtatagatc
     4261 gatccggtgg tccggtctgg ggcgtcggag gggtcgatct ggacctcata gccctcgttc
     4321 accgcagtcc acacctcgtg cccaggatcc ggaaacccga cgaacactcc ggagttgtcg
     4381 tcatcggtga tcgcccagtc cagccggagg atgtagtcct cgaactcctc tggaaaccac
     4441 agcagcccca ttccgcctct ggtcaccatc gagcactctg cgctcagctc gaacgctccc
     4501 gggccagtca tctgccactg ctcgagactt acccggctcc cgtcgaacaa cacccggtaa
     4561 ccggactcgt gcagtcctgc cgcgcactcc ggcgcttcgg cgggggcgca cgcaggaacg
     4621 gtcatgatca gcagagccac gaacgcaccc agcacgtcac gcactcgccg ccggccgtca
     4681 ccagcacgtc gcggcatgac ctggctccct ggtctccacg gcttccggcc gtggacgcac
     4741 cagtgtgaca cttccgggtc cacggccggc agacgaacca gtggccgggc tcctggtggg
     4801 gtgtccggcc actggcgttt ctgggcgtca ggcgtgctgt cggcgtgccc gggttgcgat
     4861 accggtaccg accaggagta ggagtgcggc cagggcggcc agcacaccga cgtcggctcc
     4921 ggtggtgggc aggtcaccac cggtggaccc ctcggtaggc acctcacccg aacccgtggg
     4981 gtcctggccc gggccggtcg ggtccgcacc tgggccggtg gggtccgcac ccgggtcggt
     5041 cgggtccgca cccgggtcgg tgggcgcctc ctggccggcg gtgctgaact cgaaggtcca
     5101 ctccgtggtt gcaccctccg gtagcacgta acctgctgct gcccgggcga tgatcgtcac
     5161 cgaaccctgc gccgcatagg tccctggttc gaggacctca tccggggtag gcaccaacgc
     5221 cgcagcgata tcgcgggcga gcaccgagcg tgaacccgcc acaccaggac tccccccggc
     5281 gctctcaccg agcaggacat actccacccc ctcgacctca gggatcgtga acgcatcatt
     5341 ctcggtaccg ggttcgtcgg tgaagaccac ctcttccggg gtcacctcca ccagttcccc
     5401 cggcccaccg gtggcatcga aggtgtgcga ccactccacc gtcgcaccct ccgcgagctc
     5461 ataaccctcc acggcctgcg cggtcaccgt caccgtgcct tcaccggggt gggtcccagc
     5521 ctcgatcacg tcaccaccgg ccaggtactg cacaccctcg acctcaggaa ccacgaacga
     5581 atcggagtcc gtaccgggct cgtcggtgaa cgtcacctcc tccggagtga cctgcaccgg
     5641 ttcctcgggt tcgggctgcc cagcttcgat gccggtcagg tactcaaacc ccgacgtcgc
     5701 gaaggactcc ccatcgccag ccatgtcgta ctccaacgcg taatacgcga tcggagcctc
     5761 ctgcgcggca gcgaggatct cctgcaacgc catctcgccc tcacccagat tcgtgaacgt
     5821 cggaccatcc gcaccaccca ggtcggtggc gtccttgatg tgcagcaact cgacccgatc
     5881 cccataggta ccgatcagct cgaccacatc cacacccgca tgcgcagccc aggccacatc
     5941 cagctcgaac gtcacatact ccgggttcgt ttcggccacc aggatctccc acgccgacaa
     6001 ctgctcaccc tcatgctcat acatggtcgt gaactcacca tcatggttat gaccgaagaa
     6061 cttgcccacc ccggccgcca ccgaaagctg acccagccgg ttcatcgtct ccgcagtcgc
     6121 caacgtgtcc tcatacgtgt cgatacccgg ggcagcgaaa ccacccgagc ccacatactc
     6181 ctgacccaac gtgtccacga actccaacgt ctcaccgaac gagtcctcat cgacgttgta
     6241 atgcgaggac ggaacactca acccataccc cgcagccagc tcacgaaact cctgcgcggt
     6301 gtagccctcg aagttgccac caaaaggctc aatattgaca aaaccgatct cacccaggcg
     6361 ctccaacacc gcctccagac caacctcatc cacccacgga atcagagaga acatctgcaa
     6421 cgagacatcc tccaccggaa cctcgatggg ctcaggtgac tcctcgccgt cgaccactcg
     6481 gaagtagtcg aagctcactg tggtgggttc ggcctgctgg gcgccgaggg cgtagagacc
     6541 tggggccgcg tccgcgagtg aggcgttggt gacggcactg ggcagttctt gccagtcctc
     6601 gccgtcggtc gagaacgcac cggtgaaggt gtcgccgtcc cgggtcagct gcacgtggta
     6661 ggtgccgtcg gtcggcagtg cgagatcagt caggtcgtcc tgtgggtcct gcacctcgcc
     6721 gttcacctcg ctccgcagct cgacgcgtag cggggtatcg ccgccgtcgc cggcgtagac
     6781 cgggtcgatc ttgacgtagt tgtcctcatc ggcccggacc atgatgccgc cctgctggta
     6841 cgagctctcc aggtcggcgg tgaaggccgc ctcgaccgtc cactggtccc cgctgaggac
     6901 cttggactgg agaatgttcg gcaccgggct gttgtcggtg ccgtagaagt cggcatcggt
     6961 cgtggagacg tggtacgacc cgtcactgac gtgagccagg tcgctgtcgt agtccacgat
     7021 ctcccaccgg cagggatcga cctgcgtgcc gtcgaactcg tcatccgcgg gcacgtcggc
     7081 ctccgggtcc tcgcacaccg ggggttcgga cccgctgtct cccgatgcgg cgaaggtgag
     7141 ggcatcgagg tcgacgccgc ccgtgctcgt cacgacgacc gcaccggatc cctccggggc
     7201 ctgttcgaga gcagcggtca cgtcctgcca tccggtgtcg ccggagaagt cgaacgacgc
     7261 gagcgtctcg tcctgccagt tcagcgagag agtgccctcg ccgctgccgc gggcggtgac
     7321 ggtgtcgatg ggctcaccac tcggggcgtg cgtcagtgcc accggctcga aggtgatgga
     7381 gtcaccctcc tcgaactcgg tcacgtacga cccggcgctg gcgtctgggt cgtcggcaac
     7441 gctcacgccc tcagcagagt cgtaccactc ggcctgctgc acctctggct tgagaaccag
     7501 agtcgcctcg ccggtcgtgg cagggacgtc gccctgggcc tcgtcggtgt agctgaccac
     7561 cagggtgccg aagatctttt caccctcacc gtgctccacc gcgttctcac tggtctcgag
     7621 ggtgaactca caacccgtgc cggagacctc ggggtgagcg tgcaggttgt ggcccaggcc
     7681 gaaggtccag ttgacccggt cgcacaccgg ctcgttgcca tcctcggcgt cggtcaccga
     7741 taccgagata tcgacgctgt cgccccagtt gaagatggcg ccgttgtcaa cgttcagctc
     7801 gatctccggg gcggtgttgc ccacggtgat ctcctggacg gcgaggccga acagtccctg
     7861 cgggtcggtg acacgcacga cggcggtgta ctgaccgagc tcgtcgtagg tgaagctctc
     7921 cacggcctca ccctcgacga attcaccatc gccctcgaag tcccactcat aggtgacgtt
     7981 ctcggcttcg gggtcgaccg acgccgaagc atcgaactgc acctccagcg gagcgtcact
     8041 gctggagatc tggtccgcct ccagcacggc gcgcggagtc ttgttgttcg ggttgtagtc
     8101 gatccggtag atgccggctt ccgggttctg ccggaagaag cccttgccgt actccaggac
     8161 gtacaagctg ccgtccgggc cgaactccat gtccatgatg ccggaccact cggggaccgc
     8221 ctgctcatag aggtgcgcat tgggcaggaa gttgtagatg tcggtcactt cgccgtcgct
     8281 actgagctca tccagcccga atgcggcgac gtagtcctga gagaactcgg ccatgaacgc
     8341 atggccgtcc cagacctcgg ggaactgcgt ggtcgattcg ttctcggcgt cgtagcgata
     8401 gatcgggcca cccatcgggg cctggccgcc accgtcggtg aagctgacga gtccgtccca
     8461 cgcctcaggc tggtcaccgg gctcgtcgcc ataccagatc tgcggctcgg tcaccggcgg
     8521 gagctgctcc agcccggtgt tgaaggtcga gttgttcacc ggtccggtgg cgcagtcgaa
     8581 ggtgacgtca ccggcaacac cgtcctcgaa gttccactcg ttgtaggcac cgccgtcgtt
     8641 cgggccgtgg cagtagggcc agccgccgtt catcggctcg gtcgtcagct gccactccac
     8701 ataccccatc gggccgcggt cggcctgcgc tgagccggcg tccgggccgt agtcacccca
     8761 gaccagggca ccagactcgg tgtcgaaatc gatccggaac gggttccgga cccccgtgac
     8821 gtagatctct tcccgcacca gttcggcgtc gtactcgcca gtgttgaaga gattgccctc
     8881 gggaatcgtg taagtgctct cgggccccgg ctcggcaccg gaggcgatgt cgtccagtac
     8941 gttgatccgc aggatggagc cgcgcaggtc gttggtgtta cccgaaccgc ggcgtgagtc
     9001 gaaacccggg ttcatccctg gggcgttgtt gatcggggtg tagccgttcg cgcccggggt
     9061 accggcgggt gtgttgtcac cagtggacag gtagaggttg ccgtcaccgt cgaacgcgat
     9121 gtcggcgccc acgtggcagc actgtccgcg ctgagcgtcg atcttgatga tctgctgctc
     9181 actgtcaagg tctaggttgc ccgtctccgg gtcgaactgg aagcgggaga gcacgttgta
     9241 accgagccac tggtcccagt aggtctccgg gtcggcaccc tcagggagct gttccggtgc
     9301 actacccgac ggagtggtct gcggatagtc gacaccggtc gcagacgtgc ccgacatctc
     9361 tcgcggggca taggccatgt agacccagtg gttctcctcg aagttcgggt ccagcgcgat
     9421 gccctgcagc ccgtcctcgg agttgtggta gacgtcgagc tcggcgacct gagaggtcag
     9481 gccgctggtc gggtcggtca gtcgcagcac gccgtcacgt gccgtgtgca ggacgcgtga
     9541 gtccggcagg accgcgaggt cgatcggttc accggtgtcc ttggtgagga ggagtttctc
     9601 gtagtcgctc cagtcgacac cttcgggcgc atctgcctgg accgcggccg tggcaccggc
     9661 atcatcatgc cccgggtgcg cactggcccc actcaacgtc agtggcgcta tcaccgcggc
     9721 ggctagcgcg gcggctgcac ctcgccccag ccattggctc actctggaag gtctcgacac
     9781 aatttcctcc tcgaaatctc caccaaccac gtctgccgac gtgtgcgcgg agccatctcc
     9841 tacagacatc gcctcggccg gccctggtgt tcggagcccg cggcaatgcc ggaccctgtg
     9901 tgcggaacta ccagcgggcc gctgccgcac acccgagcaa ccgtaacagg actttcgtcg
     9961 ctgtcaacac aaaagtcctg aattgccgaa cattcttcgg ctacgcacct gcctgatcct
    10021 tgatgtctct cgctccgagc gcagccgcgt acctgatcgc catatcgagc tggtccgcca
    10081 ccatcgacca ggcaggcatg acgacgtcga tcaccggctc caggccgggc gttgtcagca
    10141 ggcaacgccg cgccagcacc agctcgtggc gtgcttgcgc gtcgacccga gcgggcgcgt
    10201 cggatgcacc gagctcacgg cggatcaggt cggccgccgc cacgtccagg tccgctctgc
    10261 ccacggctga gccgatgcgg tcccagaccg ggagttcccg ggcgtagagc atgagcgtgg
    10321 tcgctttgcc ttcacgcaga tctgacagct gactcttccc ggtgaccgcc tctggtgcga
    10381 acacccccag caggtcgtca gcgagctgga atgccttgcc gagcgcttgt ccgacacggt
    10441 cgagcggctc ctggacatcg tcgggggctt gcgcgagcac tgcgccagcc cgtagcggag
    10501 cctggaaaga gtagaaggca gtcttctctg ccgcagtggt cagcgcctgc tcggccgaga
    10561 cctcccagag cccatgcgct gccgctacat cgccaagttc gccggcgacg ctgacgaaca
    10621 cggtgcgcca gagcagatcg gcgagtacgg tgcgaaccgc gaccggggcc tcgacggtgg
    10681 cggtgagccg gtgtgcgagc gcgatcgcca ggtcgccggc gagcactgcg gaggcttcgg
    10741 ccaggtgctc agccgtcgtg gtgtctgcac cctcggccgt agctgcggaa ctcattccgg
    10801 cggcgagatt agggtgtccg cggcgcagcg tgtcgtggtc gatgagatcg tcgtgcacca
    10861 gaaagcccgc gtgcagcaac tcgaacgcgg caccgagccg cgctgctgcc ggaagatcct
    10921 tcccgcacag gccagtgtag gtctcgatga cgagccggcc gcgaaagtgc ttgccacccg
    10981 agatcgcctg ctccaggtgc cgccagagca attcgtacgg ccggccgtgc cctgctgcct
    11041 ggcgccactc ctgggccacc acctcccgga gaacctcggc caccgccgcg gagggatctc
    11101 cccgcccgga ctcggccaca ctccgctccg cttcgagctg ttctggccgc tcgctcatat
    11161 cgacaccttc gggtcccgtc ttcttgtcta ccgctcgaac tttccctgct attgtgagtc
    11221 tgttaccaga acttgttcaa gttcatcgct atcaacgtcg attgtcgttg tttctacaac
    11281 gcggttcggg acaaagaggt gttaggcatg agcacaagcc caggtgagaa ggccaccgca
    11341 cgcgatggtt ctcaggtccg taccggcatc tggttcattg gtgctcgcgg gtcggtcgcg
    11401 acgacggcca ccataggctc cctggccgtg gccgccggac tcgcagaccg gaccggactg
    11461 gtcagtgagc tcgcgccgat cgccgcggca actgccccga tcgagatcgg gagtctggtc
    11521 accggggggc acgacgtcgc cgatactccg ctgcctgagc gcgccatggc gctggcggag
    11581 tcgggggtgt tcccgttcgc cctggcagct gccctgcgcg acgagctcgc cgaggccgat
    11641 aagcggatca agtcggcacc ccggcgggcg acccaacgag agacagcgtc cgcgatcgcg
    11701 gacgatctgc actccttccg cgaggagcac gggctggctc gcgtggtcgt cgtggacgtc
    11761 agcaacactg aagcgccagt acagccagga ccggagctga acgatctggc aacactcgag
    11821 gaagcgctgg acgccggacg ctcacccctg ccgcagagct cgctctatgc ctacgcggcc
    11881 ttccgtgccg gctgtgcgct cgttgcattc acgccgagcc cgggcccgaa cctccccgct
    11941 ctggtggagc tggcccagcg gcagagcgtg ccgtgggccg gtcgcgacgg aaagaccggt
    12001 gagacgctcg tcaagaccac gctggcgccg atgttcgcga cccgagcgtt gaaagtccgg
    12061 tcgtgggcgt cctataacct gctcggcggc ggagatggcc agacccttgc cgacccagat
    12121 gccgcgatga gcaagacggc aaccaagggt gccggggtcg acgcgatcct gggccaccac
    12181 gtcgacggcc cgctgcggat cgactatgtc gaagacctcg gtgactggaa aaccgcgtgg
    12241 gaccacgtct ccttcgaggg tttcctcggc accaggatga cgatgcagtt cacctggcag
    12301 gggtgcgact cggcccttgc ggcaccgctg gtgctggacc tcgtgcgact cgtggcgcga
    12361 gcgcacgaga ccggcgaagt gggcgtcatt ggtgcgatgg ccttcttctt caaggagcct
    12421 ctcggtggcg aggaacacgc cctcagcgga cagtggcaag cgctcagcga gtggtgcgag
    12481 aagctcgcca tcgctcgatg accgcccttc gggacctgat cgagctgacc cggctgccgg
    12541 cagcgctgac cgtgccagga gacaccctcg cgggagcggc cgccgccggc agcctgccca
    12601 gctggcgcgc ggctccgctc gccgcctcgt ccgcgtgcct ctactgggcc gggatggccc
    12661 tgaacgacta cgcggaccgc gagctggatg cgcaggagcg cccggagcgg ccgattcctt
    12721 ccgggcgggt cagtccatct actgcgctcc gacttgccgg tggcctcacg ctcgcgggac
    12781 tcacgctggc cgccaccgcc ggaccccgtc ccctggccgt cgccctgccc ctagcgggcg
    12841 ccgtgtggac ctacgacctg atcgcgaaac cgaccgtcgc cggtccgctg gtcatgggca
    12901 ccacccggtt tctcgacgtc ctgatgggtg gcacggccaa cccgcgacgc gctctgccgg
    12961 ccgctctcgc gttgggcgtc cacaccacag cggtcaccgt gctgagccgg ggagaggtac
    13021 acgggacttc gacccggacc gcgaccgcaa cggtggcgac tacgggcgtc gtggcgtccg
    13081 cagcggcgat ccagtcgctg cgcgatacct cccagccacc ggctgcgagg atcgccggtg
    13141 ccgccctcgc cggcacgtac gcgagtgccg tcgggcaaac gcagggcgac gccgtggcac
    13201 gccccgatcc ggcgacagta cgacgggcca cccgccgcgg gatccacggg atggttccac
    13261 tccaggccag cctgatcgcc cggcgcggtc atctcggcat cgccgccggg ctgctcgcgc
    13321 tcggcccgct cctgcgggcc gcagcgaagg tggtgtcccc cacgtgaccc ttcgcctgtc
    13381 ctatggaacg aacgggttcg gcgaccaccg gttgtcggat gctctggcga tcattgccga
    13441 cctcggctat gacggcgtgg ccctcaccct tgaccatcat cacctcgacc cgtttgcggt
    13501 cgatgtcgcg acccaggtcg gcaccatcga tcggctcttg acgacccacg gcctggccgt
    13561 ggtcatcgag accggtgccc gatacctgct cgacccccgg cgcaagcacg agccgaccct
    13621 ggtctcggcc cacgggcggg agctccgcct cgacttcctc caccgggcta tcgatatcgc
    13681 ggccgacctc ggcagcgaca tcgtgcactt ctggtccggg acgcttcctg ccggcacgtc
    13741 gatcgacact ggctgggacc ggctgctcac cggtatggcg gagatcctcc cgcacgcgga
    13801 gtccgcaggt gtgcggctgg ccgttgaacc cgaacccgga atgctcatcg aacggctcgc
    13861 cgacgcccag gagctccgca tgaggctcgg ttcgcccgac gcgctccggc tgaccctcga
    13921 cgtgggccat gccctctgca acgaagacct cacgccggat gccgcgattc gtgcggccgc
    13981 cggcgatctc atccacgtcc agatcgagga catgcgccgc ggggtgcatg agcacctgga
    14041 gttcggcgac ggtgagctcg acctggaccg ctcggtcgaa gccctgctcg aggtgcgcta
    14101 cgcagggctg gtctctgtgg aactggcacg gcacagccac gcagccccag tgacagccgc
    14161 acgctcgatc gacgcgctac gcaccgccgt cgccagctgt gaatcgcgac tggcgacgac
    14221 tcaggagccg agatgaccga gcggtaccac gcgatcctcg ccgacagact gtcaccgcag
    14281 gcgcaagacc ggctgcacca gatgaccacg gccatcggcg agaagcccgc cgccatcgcc
    14341 gtgttgttcc ccgccgcggc gagggaggtg ggccgcggac cggtggacga gggcgacccg
    14401 ggcggtgtgc tggggccgac gctggacgac atcgtccgcg gcgtcctcct cctcgccctc
    14461 gcggaggccg aacccgatcc ttcggacctg ctgcgccatg tcggtcagct gtaccggttc
    14521 ggcgacagcg aggagcggcg cgccgtccta cgcgctctgg cggacctcgg cctgggccag
    14581 ccggcccagt acctcgtcga ggatgcgtta cgcagcaacg atgtccggct gatcggtgcc
    14641 gcaatgggtg actgggccgg tgctcacctc gaggacgccg cgtggcggca gggcgtgctc
    14701 aagtgcctgt tcgtcggagt gcccctcgca gccgtggccc gcctgactga ccgtgccgac
    14761 gccgagcttg ctcgcatggt cgccgctttc gcccatgagc gtctggccgc ggggcgaacc
    14821 atcccgccgg atgcgcaccc gatcctcgac ctgttccccg ggtcgctcga acagttcccc
    14881 gacgtcggcg cagcactgga ctctgcgtcc tcaccctgat cgtcatctcc aggaggcacc
    14941 atgcgcatct tcgacccgca catccacatg acgtcccgga ccacggacga ctaccagaac
    15001 atgcgcgaag cgggggtcca ggccctcgtc gagccggcat tctggctcgg tcaaccacgc
    15061 accagcgtgg agtcgttcat cgactacttc gacgccctga tcggctggga gcgattccgg
    15121 tccgcacagt tcgggatcgc gcaccacgcg acgatcgcgt tgaatcccaa agaggccaac
    15181 gaccctcggt gtgcggaggt cctcgacctg ctgccccgct acctggccaa ggacggcgtt
    15241 gtcgctgtcg gagaggtcgg tttcgactcg atgaccgatg cggaggagca cgcattcggc
    15301 cggcagctgg agttggcgat tgagcacggt cttccggcga tggtgcacac tccgcaccgc
    15361 gacaaggctg ccggcacccg gcgcaccctc gacctggtgc gcgaggtcgg tatcgaccca
    15421 gggatggtgg tggtcgacca cctgaacgag accaccgtgg acatggtcag cgactccgcc
    15481 tgctggatgg gtttctccat ctaccccgac accaagatgg accccggccg aatggtcgcc
    15541 atcctggccc agcacggcct ggaccgggtg atggtcaact cagcggccga ctgggggcac
    15601 agcaacccgc tcagcacgct ccggacgggc gaagcgatgc tcgccgccgg cttcagcgac
    15661 gacgacgttg accgggtgct gtggcgcaac ccggtggagt tcttcgcgca gagtgggcgc
    15721 ctcatgctcg aggacaacgc gagcgacggc gcgaccttcg agggcaactc gatccagcgc
    15781 ggcgagcgca aggcccagga cgcctgacgc gatgcggctc cgacaccccg acggcaccct
    15841 cgtccacctc gcctactgca gcaatgtgca cccggccgag gaccctgccg ggatccacga
    15901 acagctgcgc cgcttcgcgg gcccggtacg ggaacgcctc ggcgtgcagc ggctgggact
    15961 cggcctgtgg ctgccggcgg ccaccgccgc cctgctggcc agcgacgagg gtgagctcgc
    16021 ggcgctgcgc gcggtcctcg atgagcaggg actggaggtc gtcacgctca acgcgttccc
    16081 ctaccgcggc ttccacgacc cggtcgtcaa acaccgcgtc tactccccag actggaccga
    16141 gcgcgcacga ctgacctata ccctcgacgc ggcgaaggtc ctcacctcgc tgctgcccga
    16201 tgatgtgcgg cgaggcagta tcagcacgct gccgctggcc tggcacaccg cgtggtcacc
    16261 cgaggcacgc agtgccgcac gagcgaatct cgacgagctc gccgcgggac tggcccgact
    16321 ccaggagagc accgggcggc aggtgcgggt cggtttcgag ccggagccgg ggtgcgtcat
    16381 cgagaccacg acgcaagcgg ccgaggaact cgccggtgtc gacaccgact acctcggcgt
    16441 gtgtctggac acctgccacc tggcgaccgc tttcgaggac gccgacgacg cggtggcccg
    16501 actgactgcg gcggggctgc cggtggtgaa gagccagctg tcggcagcgc tgcacgtccc
    16561 cgatccggcc gccgcctcgg gcgtgctcgg cacgttcgtc gaggaccgct tcctgcacca
    16621 ggtgcgcgag accggtccgg acggccggct gctggcccgg gacgacctgc ccgaggcgct
    16681 cggcggcgag gcactcggca gcgagccgct tccgggcaag cggccgtggc gcgtccactt
    16741 tcacatgcca ttgcatgccg ccccccagcc tccgctggtg aacaccgatg acgagctctt
    16801 cgccgccgcc cgggcactac tcggcggcaa gcatgcgctc accgaccatc tggaggtcga
    16861 gacctacacc tggagcgtcc taccggccga ggcgcggccg accgacgacg ccggactcat
    16921 cgcaggtctg gccgccgaac tcgcacatgc gcgtggccac ctgcacgccc tcggactgga
    16981 ggatgtatga gcaagctgct cgttctgaac gtcgtcgccc tcaccccccg catcctggag
    17041 cacatgccgc ggctgaagaa agttgcccag tcggggtacc aggccaccct ggagacggtg
    17101 ctgcctgcgg tcacctgctc ggcccagtcc acctacctca ccggcaagac acccggtgag
    17161 cacggcatcg tcgccaatgg ctggctgttc cgcgacctcg gcgacatcct gttgtggcgt
    17221 cagcacaacg gcctggtcgc cggtgagcgg gtgtgggaga cgatccgccg cacccggccg
    17281 gagtacacgg tcgcgaatgt gtgctggtgg tacgcgatgg gggcaacggt ggatgcgacc
    17341 gtgacccctc gcccggccta ctacgccgat ggccgcaagg agccggactg ctggacctgg
    17401 ccgccgtccc tgcacgactc cctcgtgtcc gagctgggac cgttcccgct gttcaccttc
    17461 tggggccccg gtgcctcgat cgacagctcc cgatggatca tcggtgccac tcgccggctg
    17521 atgccggagc acgacctcac gctggcctac gtgccgcatc tcgactatga cctccagcgc
    17581 ttcggtccct ccgggccgga ggcggtccgc gccgcccagg agctggacga ggccctggct
    17641 ccgctgctcg acgacgcgga ggcgctcggg gccacggtcg tagtcctcag cgagtacggc
    17701 atcaccgatg tctcccgcgc cgtggacgtc aaccgagtgc tgcgccgagc cggcctgctc
    17761 catgtgcacc acaacgagac cggcgaactc ctcgatacct ggacctcacc ggctttcgcc
    17821 gtggccgatc atcaggtggc gcacgtctac gtccgcaacg aggagaacct gcctcaggtc
    17881 aaggccctgc tcgaggaggt ccccggggtc gcgcaggtgc tggatgcgga aggaaaacgt
    17941 gcgcacggcc tggaccacgc cagggccggt gagctcgtgc tcgttgccga accggactcg
    18001 tggttcacct actactactg gctcgacgat gcgaacgcac ccgatttcgc caagctcgtc
    18061 gagatccaca agaagccggg ctatgacccg gtggagctgt tcatggaccc cgaggaccgg
    18121 tgggtgaagc tgcgcgcggc aacggcggtg gcccggaaga agctggggat gcggtacaag
    18181 ctggacgtgg tccctctcga tccggcaccg atccgaggca gtcacgggcg gctgcccgac
    18241 gatccgagcg aaggccccgt tctgctgtgc tcggacgccg agaatgctcg tgacctcgtc
    18301 ggtgccaccg aggtgcgaga tctgctgctg gacctcgtcg gggtccctgc tccgcgcgtg
    18361 ggctgaccgg gcgctgcgga tcgggcactg cggatcgggc gcccggcaac ggctgaccgg
    18421 gtagagtcat cgatctgtcc gttgtccgcg gtacgttgat cccaggagcc gcgcgtggcc
    18481 gtgtcaccga cgtcgcgaac caccggcccc ggtgagttgc tgcagatcct ccgtgatggc
    18541 gcgccgcgcg cccgcgcgga cctggttgcg gtcaccggtc acgcccggac cacgatcggc
    18601 agcaggatcg atgccctgct tcggaccggc ctggtgcgta ccgaagcggc gtcctccacc
    18661 ggtggccggc cgccgtcggt gtacgtcttc gatccgggtg cgcgggtggt gctcgctgtc
    18721 gatctgggcg cggtgcacct gtcagtggcc gtgctcgacc tggccggcac cgtgctcgcc
    18781 gaggaacgca ccgtctgcga tatcgccgag gggccggatc cggtgctggc ccatgtcaac
    18841 gagctcggcc agcaactgct ggaccggctg ggccggcccg ctacggacct ggccggggta
    18901 gggatcggcg ttcccggtcc ggtgcaacag accaccggcc ggccgatcac cccgccgatc
    18961 atgccgcact gggatggtgt ggacatcaag gggatcctcg gccggcagtt cggcgtgccg
    19021 gtgctggtgg acaacgatgt ggacctgatg gcgctcggtg agcacggtgc cgtttatccc
    19081 gaggtgtccc acctgttgtt cgtcaaggtc gccaccggga tcggcgccgg gatcatcgcc
    19141 aaccgcaccc tggtccgtgg caccgacggt gcagccgggg atctcggcca cgtcgcggtg
    19201 cccggcgggc gtgccgagct gtgccactgc gggaactccg gctgtctcga ggccgtcgcc
    19261 agcggcgggg ccctggtgcg agcactgcgc gccgcgggtg aagaggtcgc taccagtgca
    19321 gacgtggtgg acctggtgcg ccgcggcgat cagcgggcca cagcgttgct ccgggatgcg
    19381 ggccgcgatc tcggcgccgt gctggccggc tgcgtgaatc tgctcaaccc gtccgcgatc
    19441 gtcatcggcg gagtgctcgc ccaggccggc gagcacctgc tcgccggggc gcgcgaggtg
    19501 gtctaccggc gttcgctgcc actggccacc aagcagctgc ggatcgtcac ggcgagcact
    19561 gccggccggg ccgggctgct cggtgccggc cgggtggttg ccgaccatgt gctcgctccg
    19621 gccgccgtcg atgcgctcgc cgccgcacag acacccgtct gagtactggt gccggaggcg
    19681 ctggcgcgca ccccgcacag acgatcgtct gcagacggat tggcaggtgg agcaccgact
    19741 tcccggtcct cagcctgcaa attcatactc agacggtgga ggtggatggc ggcagcggat
    19801 gatggtggcg gtggatggca gcagcggatg gtggtggagg tggatggcgg cagcggatgg
    19861 cggcacaagg tgcggtcccg gcgttggcgg gcacggcctc accagaaccg tgcgaccgat
    19921 gagcggactt gcggtacccc gacctggagc agctttcgcc gcagtggact gccctgccat
    19981 gcatcgcgcc acccccaccg ggccagaccg cgcagtttcg cacgcatcgc gtcctcccgt
    20041 tccttctcgg cgaggagtcg ggccgcagtt gccactgtgt tgtctggtgc aaggtacttg
    20101 ctgtctccgt ccgactcgcc accaatgtcc tgctcccatc cgaagtccag gtatacgtca
    20161 ccatgggggg cgtccaggtg cagtcgcacc tgtagctgcg gagtagcgag tccgagctcc
    20221 tcgatagcca ggcgactgac cgattccagc gcactggccg acaggtgggt ggcgcggtcc
    20281 agcatcgcct gcacccggtt ggacctcggg tagggcagta ggcgctggtg catcgccatg
    20341 agctcggtca gtgtggtcag cggagcggcc ttcggtccgt acggcaggtc acgaagggcc
    20401 gcatcggccg cgaccaccgc tgcaccgagg cgcgcttgac gggcgagttg gatgagggtg
    20461 tacgcaaccg acgtgatccg cagatcacca ttctccatca agggtggatc gcagcgggtc
    20521 gcgaggcgaa caagtcggcc ctgccgcgac ccggtagccc gtccagacag gatgaagatc
    20581 tcgtccggcc atgtaccgat gatgggcagc ccgagcaggg ccgcggccga atacgaggcg
    20641 aagacggggc ggcgaagtcg acgcgctgct gccagcaccc gtgcgcggta cgcctcggcc
    20701 gcacgttctg cgggcgttcc gatgctgagc ggacgccggt acacgccggg ccacagtcgc
    20761 tcgagttttc cggaggcgac cattccttgc agcaccgccc gcataccggc gcgggtcgcg
    20821 tcggcgctgg tgaccagacc gtgggtgtcg aacggtaggg cgggcaccct ggaggattgc
    20881 gccagtcccg gcgatcggga aactgcgact ccgggcgatg gggcgactgc tggattctgg
    20941 cgagtatttc catcgccgag gacgctgtga gtcatgccgc caccccacca cgcgacagga
    21001 tctcgttgct tcaccaaccg tgggggctgt ggaaaccggt gcagaagcgg atggcagcgg
    21061 gcgctgtccg ctgggctgag taccgatttg caggctgagg accggaaatc tggtcctcag
    21121 cctgcagacc ggtactcagg cgtcgccgcg gaggcgct
//
