LOCUS       NZ_VOGX01000061        29317 bp    DNA     linear   CON 15-OCT-2024
DEFINITION  Streptomyces albidoflavus strain 77 scaffold26_cov50, whole genome
            shotgun sequence.
ACCESSION   NZ_VOGX01000061
VERSION     NZ_VOGX01000061.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 37022)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Draft Genomic Sequences of Streptomyces misionensis and Streptomyces
            albidoflavus, bacteria applied for phytopathogen biocontrol
  JOURNAL   Microbiol Resour Announc (2019) In press
REFERENCE   2  (bases 1 to 37022)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2019) Biology, UFLA, Universidade Federal de
            Lavras, Lavras, MG 37200000, Brazil
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-JUL-2019
            Assembly Method                   :: SPAdes v. 3.12
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 36.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007896905.1-RS_2024_10_13
            Annotation Date                   :: 10/13/2024 04:20:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,551
            CDSs (total)                      :: 6,456
            Genes (coding)                    :: 6,343
            CDSs (with protein)               :: 6,343
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 5 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 34 of 113
            Pseudo Genes (incomplete)         :: 81 of 113
            Pseudo Genes (internal stop)      :: 8 of 113
            Pseudo Genes (multiple problems)  :: 8 of 113
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:41:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 29317
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VOGX01000061.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29317
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..29317
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29317
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[4922:9317](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4923..9317)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            34..165
                     /locus_tag="FRZ02_RS33655"
                     /old_locus_tag="FRZ02_30595"
     CDS             34..165
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRZ02_RS33655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FRZ02_30595"
                     /product="hypothetical protein"
                     /protein_id="WP_261399662.1"
                     /transl_table=11
                     /translation="MTDTVTVSDRPAQPVRQLLAASVGNAVEWYDWFSCTGTSGHTF"
     gene            complement(413..1054)
                     /locus_tag="FRZ02_RS30600"
                     /old_locus_tag="FRZ02_30600"
     CDS             complement(413..1054)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027402.1"
                     /locus_tag="FRZ02_RS30600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30600"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_033238468.1"
                     /transl_table=11
                     /translation="MISPALLATGENTTPSERRRAERTADDAATTIWALAARDGDPAAV
                     DRFFRALHRDVRYFVTFLGADPEAAEDLAQDTFLRALGSLHSFEGRSSARAWLLSIARR
                     AVIDSYRYASVRPRLADVEDWQRVAERTQDPGLLGFEDGVAMEELLNALPVERREAFVL
                     TQLVGMSYAEVALVCGCPVGTIRSRVARARAVLMRLLGEAERGEPAAGAA"
     gene            complement(1247..1909)
                     /locus_tag="FRZ02_RS30605"
                     /old_locus_tag="FRZ02_30605"
     CDS             complement(1247..1909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001847.1"
                     /locus_tag="FRZ02_RS30605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30605"
                     /product="hypothetical protein"
                     /protein_id="WP_037841364.1"
                     /transl_table=11
                     /translation="MSVGRGLRTVRCALFALVCVLLAALAHVMMSGSAVPWWALGTGAT
                     AGAAIAWCLAGRERGLLLVSSVVAATQLALHEWFTYAQRLLPPAATAKGHSVHAEGVAA
                     AHEHLHHLGHPGLDVPATGAGPVPEGFSSAGMMTAHILAALLSGLWLAHGERAVFRILR
                     ALASRLTVPARLLHDRPETPVRARVPACRHRVPHGPRLRLLTHAITSRGPPGTAAVL"
     misc_feature    complement(1889..1891)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    1951..1964
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.55"
                     /tool="antismash"
     gene            complement(2007..2855)
                     /locus_tag="FRZ02_RS30610"
                     /old_locus_tag="FRZ02_30610"
     CDS             complement(2007..2855)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556087.1"
                     /locus_tag="FRZ02_RS30610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30610"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_051701240.1"
                     /transl_table=11
                     /translation="MKLTVDQVHVELEGTPVLQGVDLEVLPGSVVGLVGPNGSGKSTLL
                     RTVYRSLRPTRGVVRVGEDDVWRLAPRTAARRTAAVLQDAAGGGGLSVREIVELGRTPH
                     HRLISRESTADRQAVSDAIDRCGISAFATREYASLSGGERQRVLLARALAQQPRLLVLD
                     ELTNHLDIRARFELLDLIRATGVSTLAVLHDLDLAARLCDLIVVLDHGRAVAAGPVLDV
                     LTPVVMREVFGVEASTARHDDGVVRIAYAARPLARHSDSATCRGSARRATAGGMVDSAG
                     R"
     gene            complement(2852..3817)
                     /locus_tag="FRZ02_RS30615"
                     /old_locus_tag="FRZ02_30615"
     CDS             complement(2852..3817)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126681.1"
                     /locus_tag="FRZ02_RS30615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30615"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_067417607.1"
                     /transl_table=11
                     /translation="MITAISIGAVTVPVADVWNVVAHHLTGQGATDDPALDQIVWNFRT
                     PRVLLAALAGAGLAVAGAVLQTLVANPLADPTVLGFSYGASFGAVLVITLGGIGIGGVG
                     VAGAAFLGALATGAGVFALGRRRGRLAPTRLVLAGVAVGYVLLSATSFVQLWATPTELR
                     TVMFWMLGSVAGAQWGQLPVVAAIVLTCTALLGLFGGRLNALLAGDESATALGVDVDRL
                     RAVLLVITALLTGSVIAVAGGIGFVGLMIPHLVRLTLGADHRRLLPLTALLGAVYLVLV
                     DLLSRTLIRPNELPLGILTALLGAPFFIWRLRRNKSLDTT"
     gene            complement(3874..4914)
                     /locus_tag="FRZ02_RS30620"
                     /old_locus_tag="FRZ02_30620"
     CDS             complement(3874..4914)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010355876.1"
                     /locus_tag="FRZ02_RS30620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30620"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_037841368.1"
                     /transl_table=11
                     /translation="MSTKRIALLGATAVISLVTAGCGGLSEGTTGAAGEPAASSSAEGY
                     PVTLENCGVKQTFTKAPSRVVVMNGASVAEVSTLLALGLEDRIVVNQQTYGKSEVPGRA
                     DEIKALPKGDIKLNDAFDIPREAMLAQRPDLVLSTTAYGFDGKNGFATRDQLKQVGANS
                     YVSPQGCDQDTSKMTMEDSRRLLRDMGKVFGVSERAEKLIAESDRRIAEVTEKVKGGEK
                     PKVMVIFSNMSMGGNDFSSVVAKGIYNDILARAGGTNAFENASKGSFADLSKEKVAAAD
                     IDALVVISYNDPDPTAYAKKLLKEFPQWTAAKNDAYVVLSDSIYLGPSNDVAVEKIAEM
                     LHPDAL"
     gene            complement(4923..9317)
                     /locus_tag="FRZ02_RS30625"
                     /old_locus_tag="FRZ02_30625"
     CDS             complement(4923..9317)
                     /NRPS_PKS="Domain: Condensation_Starter (7-303). E-value:
                     1.3e-102. Score: 335.1. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS30625_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (468-855). E-value: 1.7e-83.
                     Score: 272.4. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS30625_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (965-1032). E-value: 8.7e-14. Score:
                     43.5. Matches aSDomain: nrpspksdomains_FRZ02_RS30625_PCP.1"
                     /NRPS_PKS="Domain: TD (1072-1309). E-value: 3.4e-77. Score:
                     250.9. Matches aSDomain: nrpspksdomains_FRZ02_RS30625_TD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056143.1"
                     /locus_tag="FRZ02_RS30625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30625"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_107436726.1"
                     /sec_met_domain="Condensation (E-value: 1.1e-48, bitscore:
                     156.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-90, bitscore:
                     294.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.4e-11, bitscore:
                     33.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.3e-56, bitscore:
                     182.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTREQDLRRHPLLGAQEGIWTGHQLDTSSPAYNTAEYVTIEGPVD
                     ADHFETALRQAVEETEALHGVFVADDTGQPWQVDTAIPEWRLHTADVSGAPDPHAAALR
                     WIHDDIARPVDLSHGPLFGHALFRLAADRHLWYHRVHHIALDGFGLSLFARRVADLYTA
                     FVARTEPDPSGFGTLASVREEEAAYRSSDQFARDREYWLHRYADRPDVATPAGHSALPA
                     HSFLRDTADLGAATTAALRATARDLRASWSEILLALTAAHLHRATRAPEVVLSVPAMGR
                     FGSVSLRVPAMVRNVLPLRVPVGPDDTLRTLTSAVSRELRAALPHQRCRYEQIRRDLRL
                     VGAGRRLSGPGVNIMPFAYDLRFAGYRSTVHNVSAGPVDDLAFNVYDRSEGGSLRFAVD
                     AHPGLYTLDEVKGHRRALFELLTEAVAEPDRLLSSLAPALPSHVPAPTIRVLEGEPLPA
                     SPRPVLSLIADHADRRGGAVAVEEGERSITYAGLVEHSRDVARRLAGCGVNRGDLVAVA
                     LPRGIEAVTVMLGVMAAGAVYCPLDPDAPADRTAALLSISVPALVITQHRHAHLFHDRE
                     ILLLGASTGTEHGQPPMSAPGPEEPAYVLHTSGSTGQPMGVEVGHGALAHFVAGAGLRY
                     GPGRTDRVLQFAPPHFDTSIEEIFLTLCSGATLVIREPDMTDSVPHFLSACERLSVTVL
                     DLPTAYWHELAYALSTGADTLPGAVHTVIIGGETALPERAARWRECVGTGVRLVNTYGP
                     TEGTVVATAADLGDPCLAPGDAPIGIPLPGSRVALIDGELYLLGPALAHGYRNRPVETA
                     ERFVRLERLPDAPRAYRTGDLVELGEDGLLRHLGRVDDEFKISGHRVQPPEVESALLSH
                     PGIGDAAVTGQVLPDGTRRLTAHLVAVGPEPASSSVRAHLQARLPAPMIPTSLTFLPRL
                     PRTSSGKTDRAALLAGLPLQQHSPAGPDGERTLTEIVTDVWRQVLTSGELSERDDVFER
                     GAQSLQAIQAANRLAAKLGREVKLAWLFQCATPAALAAFLSSEAASGSQTPAGAALPHS
                     LVADARLDPAVRPGARKAPWPPRRILLTGATGFVGSHLLAQLLRATDAEVVCAVRAAGP
                     EAALDRVRSALSAADLTLSPDQHRRVTALPADLARPRLGLSEQRWNALGSTVDAILHNG
                     SAVSVVRDYTALRPANTDSTHDLLRLAAPRRVPLHYVSTLSVVPDAAGAESKETFLPVH
                     EGLRYGYQQTKWASEHLLEQAAERGLPVTVHRLGRVVGPVGTGRVNRQDFLWIVLRAGV
                     PAGLVPDLFAEESWTPADRVASEVVATGPGAHEPVAVVHHHAGSTVRQADLHRWLREYG
                     YAIEALPLDAWRQRIPRDTPDAVAVLTFFDSLPAPWAGADDGLALTTVQADQERAALAA
                     GDSSVRPAHQEIDRAAFFRQLDHCVAQGDLPAPAHHGPREPGTDPAPRPTLATNPGDEP
                     AAN"
     aSDomain        complement(5391..6101)
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30625_TD.1"
                     /evalue="3.40E-77"
                     /label="FRZ02_RS30625_TD.1"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="1309"
                     /protein_start="1072"
                     /score="250.9"
                     /tool="antismash"
                     /translation="ILLTGATGFVGSHLLAQLLRATDAEVVCAVRAAGPEAALDRVRSA
                     LSAADLTLSPDQHRRVTALPADLARPRLGLSEQRWNALGSTVDAILHNGSAVSVVRDYT
                     ALRPANTDSTHDLLRLAAPRRVPLHYVSTLSVVPDAAGAESKETFLPVHEGLRYGYQQT
                     KWASEHLLEQAAERGLPVTVHRLGRVVGPVGTGRVNRQDFLWIVLRAGVPAGLVPDLFA
                     EESWTPADRVASEVV"
     aSModule        complement(5391..9296)
                     /complete
                     /domains="nrpspksdomains_FRZ02_RS30625_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_FRZ02_RS30625_AMP-binding.1"
                     /domains="nrpspksdomains_FRZ02_RS30625_PCP.1"
                     /domains="nrpspksdomains_FRZ02_RS30625_TD.1"
                     /final_module
                     /locus_tags="FRZ02_RS30625"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     aSDomain        complement(6222..6422)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30625_PCP.1"
                     /evalue="8.70E-14"
                     /label="FRZ02_RS30625_PCP.1"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="1032"
                     /protein_start="965"
                     /score="43.5"
                     /tool="antismash"
                     /translation="IVTDVWRQVLTSGELSERDDVFERGAQSLQAIQAANRLAAKLGRE
                     VKLAWLFQCATPAALAAFLSSE"
     CDS_motif       complement(6723..6788)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0008"
                     /evalue="3.20E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="865"
                     /protein_start="843"
                     /score="19.7"
                     /tool="antismash"
                     /translation="HLGRVDDEFKISGHRVQPPEVE"
     aSDomain        complement(6753..7913)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30625_AMP-binding.1"
                     /evalue="1.70E-83"
                     /label="FRZ02_RS30625_AMP-binding.1"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="855"
                     /protein_start="468"
                     /score="272.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DHADRRGGAVAVEEGERSITYAGLVEHSRDVARRLAGCGVNRGDL
                     VAVALPRGIEAVTVMLGVMAAGAVYCPLDPDAPADRTAALLSISVPALVITQHRHAHLF
                     HDREILLLGASTGTEHGQPPMSAPGPEEPAYVLHTSGSTGQPMGVEVGHGALAHFVAGA
                     GLRYGPGRTDRVLQFAPPHFDTSIEEIFLTLCSGATLVIREPDMTDSVPHFLSACERLS
                     VTVLDLPTAYWHELAYALSTGADTLPGAVHTVIIGGETALPERAARWRECVGTGVRLVN
                     TYGPTEGTVVATAADLGDPCLAPGDAPIGIPLPGSRVALIDGELYLLGPALAHGYRNRP
                     VETAERFVRLERLPDAPRAYRTGDLVELGEDGLLRHLGRVDDEFKIS"
     CDS_motif       complement(6873..6947)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0007"
                     /evalue="5.10E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="815"
                     /protein_start="790"
                     /score="31.6"
                     /tool="antismash"
                     /translation="GELYLLGPALAHGYRNRPVETAERF"
     CDS_motif       complement(7455..7514)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0006"
                     /evalue="2.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="621"
                     /protein_start="601"
                     /score="20.2"
                     /tool="antismash"
                     /translation="AYVLHTSGSTGQPMGVEVGH"
     CDS_motif       complement(7692..7733)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0005"
                     /evalue="9.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="542"
                     /protein_start="528"
                     /score="12.6"
                     /tool="antismash"
                     /translation="LGVMAAGAVYCPLD"
     CDS_motif       complement(8256..8369)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0004"
                     /evalue="4.30E-18"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="354"
                     /protein_start="316"
                     /score="57.8"
                     /tool="antismash"
                     /translation="SRELRAALPHQRCRYEQIRRDLRLVGAGRRLSGPGVNI"
     aSDomain        complement(8409..9296)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30625_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="1.30E-102"
                     /label="FRZ02_RS30625_Condensation_Starter.1"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="303"
                     /protein_start="7"
                     /score="335.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIALDG"
                     /tool="antismash"
                     /translation="RRHPLLGAQEGIWTGHQLDTSSPAYNTAEYVTIEGPVDADHFETA
                     LRQAVEETEALHGVFVADDTGQPWQVDTAIPEWRLHTADVSGAPDPHAAALRWIHDDIA
                     RPVDLSHGPLFGHALFRLAADRHLWYHRVHHIALDGFGLSLFARRVADLYTAFVARTEP
                     DPSGFGTLASVREEEAAYRSSDQFARDREYWLHRYADRPDVATPAGHSALPAHSFLRDT
                     ADLGAATTAALRATARDLRASWSEILLALTAAHLHRATRAPEVVLSVPAMGRFGSVSLR
                     VPAMVRNVLPLRVPV"
     CDS_motif       complement(8418..8507)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0003"
                     /evalue="2.70E-09"
                     /label="C5_starter_265-294"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="300"
                     /protein_start="270"
                     /score="29.4"
                     /tool="antismash"
                     /translation="EVVLSVPAMGRFGSVSLRVPAMVRNVLPLR"
     CDS_motif       complement(8835..8900)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0002"
                     /evalue="3.40E-11"
                     /label="C3_starter_134-155"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="161"
                     /protein_start="139"
                     /score="35.8"
                     /tool="antismash"
                     /translation="VHHIALDGFGLSLFARRVADLY"
     CDS_motif       complement(9114..9230)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30625_0001"
                     /evalue="4.40E-17"
                     /label="C2_starter_024-063"
                     /locus_tag="FRZ02_RS30625"
                     /protein_end="68"
                     /protein_start="29"
                     /score="54.6"
                     /tool="antismash"
                     /translation="PAYNTAEYVTIEGPVDADHFETALRQAVEETEALHGVFV"
     gene            complement(9307..9576)
                     /locus_tag="FRZ02_RS30630"
                     /old_locus_tag="FRZ02_30630"
     CDS             complement(9307..9576)
                     /NRPS_PKS="Domain: PP-binding (8-68). E-value: 3.5e-11.
                     Score: 35.2. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS30630_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056142.1"
                     /locus_tag="FRZ02_RS30630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30630"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_037841370.1"
                     /sec_met_domain="PP-binding (E-value: 6.8e-13, bitscore:
                     40.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSALTLQQFRADLAEVLHQEPEEVDLEDSPVSAGLDSLRLVTLV
                     ERWEQHGIVVSFIDLAELPSFRGWWQLLAELQEEGREAGRRGDA"
     aSDomain        complement(9373..9552)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30630_PP-binding.1"
                     /evalue="3.50E-11"
                     /label="FRZ02_RS30630_PP-binding.1"
                     /locus_tag="FRZ02_RS30630"
                     /protein_end="68"
                     /protein_start="8"
                     /score="35.2"
                     /tool="antismash"
                     /translation="QFRADLAEVLHQEPEEVDLEDSPVSAGLDSLRLVTLVERWEQHGI
                     VVSFIDLAELPSFRG"
     gene            complement(9622..11214)
                     /locus_tag="FRZ02_RS30635"
                     /old_locus_tag="FRZ02_30635"
     CDS             complement(9622..11214)
                     /EC_number="6.2.1.3"
                     /NRPS_PKS="Domain: AMP-binding (26-424). E-value: 2.9e-98.
                     Score: 321.1. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS30635_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468669.1"
                     /locus_tag="FRZ02_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30635"
                     /product="long-chain-fatty-acid--CoA ligase"
                     /protein_id="WP_033238463.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-107, bitscore:
                     350.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELPQKPRQGARLHHGLTTLVDTTHFHAEHQPDTPAVVCGAATLT
                     YADLHRESSRAARALRSAGLSPGDRVAYLGKESERYYEILFACAKTGTVLVPVNWRLTS
                     PEVSHILEDSGTRLLFVEDEFHRVVDGMPSAVPEHVVVLDAAEGYATWKATATGGDEVY
                     EATRDTPVAQLYTSGTTGLPKGVVLAHRSFFAIADAMAQADVDWIDWQAGDVALIGIPG
                     FHIGGLWWATQNLNAGTTVVAMPAFDAAEAVELIRRRGVTTTCVVPAMLRMMLTRPGVV
                     PADFATLRKIVYGGSPISETLLEQSLAVFRCEFAQIYGLTETGNTAVCLPPAAHEPGSS
                     LMQAAGRPYPGVQVKVVDDHGTVLPLGAVGEVCLGTPARMVEYWNLPDKTAETLVEGWI
                     RTGDAGFLDEDGYVHIRDRIKDAILVAGENVYPAEIENVLERHPGVAEAVVVGAPDDRW
                     GEYVHAFVVPEDRAGEPLRARDLHTFLTPRLAAFKLPAKYEFIDHVPRNPSGKILRREL
                     RNRFWDGSDRKVN"
     aSDomain        complement(9943..11136)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30635_AMP-binding.1"
                     /evalue="2.90E-98"
                     /label="FRZ02_RS30635_AMP-binding.1"
                     /locus_tag="FRZ02_RS30635"
                     /protein_end="424"
                     /protein_start="26"
                     /score="321.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HAEHQPDTPAVVCGAATLTYADLHRESSRAARALRSAGLSPGDRV
                     AYLGKESERYYEILFACAKTGTVLVPVNWRLTSPEVSHILEDSGTRLLFVEDEFHRVVD
                     GMPSAVPEHVVVLDAAEGYATWKATATGGDEVYEATRDTPVAQLYTSGTTGLPKGVVLA
                     HRSFFAIADAMAQADVDWIDWQAGDVALIGIPGFHIGGLWWATQNLNAGTTVVAMPAFD
                     AAEAVELIRRRGVTTTCVVPAMLRMMLTRPGVVPADFATLRKIVYGGSPISETLLEQSL
                     AVFRCEFAQIYGLTETGNTAVCLPPAAHEPGSSLMQAAGRPYPGVQVKVVDDHGTVLPL
                     GAVGEVCLGTPARMVEYWNLPDKTAETLVEGWIRTGDAGFLDEDGYVHIRDRIKDAIL"
     CDS_motif       complement(10039..10122)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30635_0002"
                     /evalue="2.10E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="FRZ02_RS30635"
                     /protein_end="392"
                     /protein_start="364"
                     /score="23.3"
                     /tool="antismash"
                     /translation="PLGAVGEVCLGTPARMVEYWNLPDKTAE"
     CDS_motif       complement(10645..10695)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS30635_0001"
                     /evalue="1.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="FRZ02_RS30635"
                     /protein_end="190"
                     /protein_start="173"
                     /score="21.1"
                     /tool="antismash"
                     /translation="LYTSGTTGLPKGVVLAH"
     gene            complement(11259..11792)
                     /locus_tag="FRZ02_RS30640"
                     /old_locus_tag="FRZ02_30640"
     CDS             complement(11259..11792)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056140.1"
                     /locus_tag="FRZ02_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30640"
                     /product="FcoT family thioesterase"
                     /protein_id="WP_051701241.1"
                     /transl_table=11
                     /translation="MTVTGASVLRTYATDKALLSRVLVPYKDHCRYLLTAEVSALPDGL
                     ARVEGAFAIPESCYIEDTGHLNAVEVNIAYNQMMYYLVAKSVKEGLLAGLQSWTLEDFW
                     AHQLPDILIARFTSRFQRPVDPRDFHGEMELRSMDRRSPGGRPLLMAATTYRYGDVQGG
                     RCDGDATLAFVNFT"
     gene            complement(11789..12679)
                     /locus_tag="FRZ02_RS30645"
                     /old_locus_tag="FRZ02_30645"
     CDS             complement(11789..12679)
                     /NRPS_PKS="Domain: TauD (8-273). E-value: 5.8e-41. Score:
                     132.9. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS30645_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056138.1"
                     /locus_tag="FRZ02_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30645"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_078850258.1"
                     /sec_met_domain="TauD (E-value: 3.1e-41, bitscore: 132.9,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRITHHTGTSIGASVEDFDHTSASPADVMALKETVYRRKIAVLKG
                     QDLSPQAFLELGRRLGRPETYYEPMYHHPQVPEVFVSSNVPEDGRQIGVPKTGKFWHAD
                     YQFMPDPFGITLIYPQVIPAKNRGTYFIDMGTAYERLPEDLKGEVEGTRCLHSVRKYFK
                     VRPHDVYRPLSEIIQEVEEKTPAVRQPTVFTHPMTDEKVLYLSEGFTVGIEDEKGEPLG
                     ESLLQRLFEATGQLDRDFGHENIHLQTFERGDLLVWDNRSLIHCARHTTTPEPTVSFRV
                     TVHDERKLHAGLEKA"
     aSDomain        complement(11861..12655)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30645_TauD.1"
                     /evalue="5.80E-41"
                     /label="FRZ02_RS30645_TauD.1"
                     /locus_tag="FRZ02_RS30645"
                     /protein_end="273"
                     /protein_start="8"
                     /score="132.9"
                     /tool="antismash"
                     /translation="TSIGASVEDFDHTSASPADVMALKETVYRRKIAVLKGQDLSPQAF
                     LELGRRLGRPETYYEPMYHHPQVPEVFVSSNVPEDGRQIGVPKTGKFWHADYQFMPDPF
                     GITLIYPQVIPAKNRGTYFIDMGTAYERLPEDLKGEVEGTRCLHSVRKYFKVRPHDVYR
                     PLSEIIQEVEEKTPAVRQPTVFTHPMTDEKVLYLSEGFTVGIEDEKGEPLGESLLQRLF
                     EATGQLDRDFGHENIHLQTFERGDLLVWDNRSLIHCARHTTTP"
     gene            complement(12721..12957)
                     /locus_tag="FRZ02_RS30650"
                     /old_locus_tag="FRZ02_30650"
     CDS             complement(12721..12957)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (6-72). E-value: 3e-12.
                     Score: 38.6. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS30650_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056136.1"
                     /locus_tag="FRZ02_RS30650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30650"
                     /product="acyl carrier protein"
                     /protein_id="WP_067417601.1"
                     /sec_met_domain="PP-binding (E-value: 3.4e-11, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETYTQLVSIVSGLHDAPADRFRPETSYEDLDVDSLTMVEISIH
                     IERHLGVTVEDSELVPGLTLGATAELIEAHLTA"
     aSDomain        complement(12742..12939)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS30650_PP-binding.1"
                     /evalue="3.00E-12"
                     /label="FRZ02_RS30650_PP-binding.1"
                     /locus_tag="FRZ02_RS30650"
                     /protein_end="72"
                     /protein_start="6"
                     /score="38.6"
                     /tool="antismash"
                     /translation="QLVSIVSGLHDAPADRFRPETSYEDLDVDSLTMVEISIHIERHLG
                     VTVEDSELVPGLTLGATAELI"
     gene            complement(12954..14015)
                     /locus_tag="FRZ02_RS30655"
                     /old_locus_tag="FRZ02_30655"
     CDS             complement(12954..14015)
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056134.1"
                     /locus_tag="FRZ02_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30655"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_067417598.1"
                     /sec_met_domain="fabH (E-value: 2.4e-108, bitscore: 353.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGTSPQRPSRAAVLCGVGGQLPWLKVGNDELADQLDTDDAWIRT
                     RTGIRARHFAAPDEATSDLAVAAGRRALANSGSATVGAVIVATTTPDRTCPATAPLVAA
                     RLGLTGVAAFDVGAVCSGFVYALAAGAGLITSRVTDRVLVVGADLYTRIVDPGDRQNAV
                     VFGDGAGAVVLRTGHDTEPGALGFFDLGSDGVHEDMITVPAGGSRLPVDPARTSHAEKH
                     FTMRGKEVYRHAVRRMAGSARAVLEQAGLSIGEIDLFVPHQANLRILRTVATDLGLPFE
                     RCATHVQEMGNTGAASIPLALARSHVDGASGVGDRILLTGFGGGLTWGSCLLTWPSLPP
                     AVEPSRPEEEAAP"
     gene            complement(14058..15461)
                     /locus_tag="FRZ02_RS30660"
                     /old_locus_tag="FRZ02_30660"
     CDS             complement(14058..15461)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056133.1"
                     /locus_tag="FRZ02_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30660"
                     /product="MFS transporter"
                     /protein_id="WP_037841375.1"
                     /transl_table=11
                     /translation="MSVTTAGPAAVRRRLGLPMVVLAVAQLVISLDHSIVYVALPQIGA
                     SLGFVDHDLQWVVSAYVVATGGFLLLGGRAADLLGRRRMFVVATSVYGLASLVGGLAQS
                     PGVLLCVRAAQGLGGALLFPATLALINTTYAEGPSRNRALALWGAAGAGGLCLGSLLGG
                     ALVHSYGWPSVFLVNVPVALALAVLGRFVFAVDPVPDRRRRFDVAGSLTATAGLTSLVF
                     LLVYAPAVGWTRPAALIAGTLALLSLFLLVVIEARTPGPLLPVRLLRHRGLAAAAALAA
                     LFSATFSSLPYFLTLYFQTVRGYDALATGLCFLLPALVVAAGTQAGAPAVSRFGVRPLL
                     AGGLGAGAAGTLALVPAVSAQSPYGVLVPGIVLTSLGQGAVWTALWIAAARGISPGDQG
                     MASGIASTSLQVGGAVGLALLVAAASGIGAESSIPVLVDGMRVALLLTSGALTLGMLLL
                     FVPRSRAAA"
     gene            complement(15626..16375)
                     /locus_tag="FRZ02_RS30665"
                     /old_locus_tag="FRZ02_30665"
     CDS             complement(15626..16375)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056132.1"
                     /locus_tag="FRZ02_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30665"
                     /product="aspartyl/asparaginyl beta-hydroxylase
                     domain-containing protein"
                     /protein_id="WP_037841376.1"
                     /transl_table=11
                     /translation="MQSTDERFAAIREEFGPHSLRRVEEMMNSGGRSRHAMQAGAKWIL
                     PGISQQPWHDPRGNPEIASFVDALEGGHRAIREEHERAWRAKPGAFSQYEHYLTRQEDW
                     QSLHLYRDGGLVADAAEIAPTAFGLIRDVAVARGLICPLLESHFSTLLPGARIAPHCDL
                     WNFSINLHFAVDIPDGCDITVGGETRTWEEGRCLLFDYSFEHHAENRGPRPRTCLLADL
                     WHPETTVPERQALTILVTEVRRSLSGT"
     gene            complement(16557..17186)
                     /locus_tag="FRZ02_RS30670"
                     /old_locus_tag="FRZ02_30670"
     CDS             complement(16557..17186)
                     /EC_number="4.2.1.-"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056131.1"
                     /locus_tag="FRZ02_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30670"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_037841378.1"
                     /transl_table=11
                     /translation="MQIAIVLYPGFTALDVVGPYEVLARLPGADVFFVAENPGLVLNDL
                     GSLSVKVVHGFEEVPNPDVVLVGGGAGQADQMADGALHAWLRAVGSSATWMTSVCTGSL
                     ILAAAGVLAGRRATTHWGALEQLAEFGATPSKERVVIDGHCATGAGVSAGIDMALTLAG
                     LIAGDRVAQAVQLLIEYAPQPPYEAGSRDAASDEVYDALLGLVGPH"
     misc_feature    complement(17118..17120)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17176..17189)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(17406..17861)
                     /locus_tag="FRZ02_RS30675"
                     /old_locus_tag="FRZ02_30675"
     CDS             complement(17406..17861)
                     /GO_function="GO:0016531 - copper chaperone activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487536.1"
                     /locus_tag="FRZ02_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30675"
                     /product="copper chaperone PCu(A)C"
                     /protein_id="WP_037841379.1"
                     /transl_table=11
                     /translation="MVAAASLVAVGGLATWASAGYAGTPADVQVKQARVLLPVTPGGNT
                     NAYFHLVNSGGAPDRLRAVTSSGAAEPELTEHRMNDANGAYREPVKTVTVPADGEVRMS
                     PHSTAVNLRADRAWRPGDRVTFTLDLERSGRMTVQAVVRPVTLGSGF"
     gene            complement(18004..20298)
                     /locus_tag="FRZ02_RS30680"
                     /old_locus_tag="FRZ02_30680"
     CDS             complement(18004..20298)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487535.1"
                     /locus_tag="FRZ02_RS30680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30680"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_067417596.1"
                     /transl_table=11
                     /translation="MTAETADTRVVTDLVVDGMTCAACVRRVERKLGRLEAVTAEVNLA
                     TGRARVSHPAGMTTGELTAVVEAAGYRVRQVAPEAQERPDGRAGPAAHDTRQERERLLV
                     TAALSLPVLVLSMAPPLQFDNWQWLCFMLAAPVATWGAWPFHRRALSGIRHATATMDTL
                     VSLGVVASFCWSSYALFLGGAGAVGMRMPFSLVPSASDGMAHVYLEAAVGVPLFVLLGR
                     YLEGRARRGTGAALRSLARLAAKVVTVRRGGVDELVPIERLMVGEVFLVRPGERAATDG
                     EVAEGSSAVDLSLVTGESEPVEVGPGSPVTGGSVNVGGLLLVRATAVGRDTQLARITQL
                     VMEAQAGKARAQGLADTVAGLFVPVVLALAATTLGFWLGAGADAQAAVTAGVAVLVVAC
                     PCALGLATPTALMAATGRGAQLGVLVRGAHALEGLQHVDTVVLDKTGTLTSGHMSVGRV
                     TVAGGELTEPDVLRLAGAVEHGSEHPLGRALSLHARRAAADEALPHVTAFRSIAGHGVS
                     GTVEGHEVEVVAPDSSDLPPVLAAACRRADERARTAVLVRVDGTPTAVVEVSDLVRPGS
                     YRAVDRLRRLGIRPVLATGDRAAVARVVAEDLGIAEVHSRCTPGEKVELVRRLRAEGRR
                     VAVVGDGVNDAAALACADLGIAVGTGADAAIGASDVTLVRNDVEALADAVRLARHTLRT
                     IRTNLVWAFGYNVVTMPLAMVGLLNPMVAAVAMSLSSVLVVVNSLRLRSWRPSTHPGPG
                     VRATPRPRSIA"
     gene            complement(20298..20522)
                     /locus_tag="FRZ02_RS30685"
                     /old_locus_tag="FRZ02_30685"
     CDS             complement(20298..20522)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122403.1"
                     /locus_tag="FRZ02_RS30685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30685"
                     /product="hypothetical protein"
                     /protein_id="WP_051701242.1"
                     /transl_table=11
                     /translation="MELTVTPVTRAGTVRSVPPPALWGFLLLLGALFVGAYVVGNAVGP
                     VAPGMHAPGITGGTPPGEQDAPMHHGGGH"
     misc_feature    20507..20521
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.42"
                     /tool="antismash"
     misc_feature    20623..20638
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(20745..22223)
                     /locus_tag="FRZ02_RS30690"
                     /old_locus_tag="FRZ02_30690"
     CDS             complement(20745..22223)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091463.1"
                     /locus_tag="FRZ02_RS30690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30690"
                     /product="PepSY domain-containing protein"
                     /protein_id="WP_037841382.1"
                     /transl_table=11
                     /translation="MTDTTGVPDARPAPPKAVAERVPQKPPGTSAWSALRPLVLRLHFF
                     AGLLVAPFLLVTALSGMLYALSIPGEKLVYQHELSVSAPENGTRLPLEQQVEAARAAHP
                     ELEVTSVWAPAEAEDTTRVLFADPSLGASKSQAVFVDPYTAEVRGELVQYGSSGALPLR
                     TWISEFHRHLHLGEPGRIYSELAASWLWVVVLGGVMLWIGRRRGRPGARGFLLPRRGMD
                     KGRSRTLNRHAVLGVWAAVGLIMISATGLTWSTYAGARIGAVQDGLGGATPVLGAELTP
                     GEEGGAHDEHAGHEGHGGQHTGGSEASGPDVGLDAAVAAAAARGVDAGVVVTMPTDGQG
                     YKVAESDKQVPVHLDAVSVDPRNGEILSELRFADYPLLAKLTRFGIDAHMGYLFGLPNQ
                     LALAALVGVLLLLIVWGYRMWWLRRPAGRTVGRPMPRGGLRALPVGLLVPLIAVVAFVG
                     WFLPLLGISLLVFLAIDVLLGIRARRSREERPVS"
     gene            complement(23184..24098)
                     /locus_tag="FRZ02_RS30695"
                     /old_locus_tag="FRZ02_30695"
     CDS             complement(23184..24098)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981374.1"
                     /locus_tag="FRZ02_RS30695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30695"
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_234312971.1"
                     /transl_table=11
                     /translation="MGGRVTLRGDLRLALPDAAAAVGVTAAVFVFLYVRMESGTSATVA
                     VMPFMDDPRTYWMYLLSQAFGWSALLWAWGTVMIGLLVSGTRPEALRVSPQTLERWHRT
                     TSLTTMALMLAHALMFAAELVRYEAQLGWAERLWAAFADSFVPGWYDSGTGQIAIPIGQ
                     AALYLAVPLGLLFYVRHRIGARTWRVLHRFVIVVYVLSVWHTLLYGTNVWYGEWPRTVL
                     WLLQIPVAVLLLARLVGPARRSERLGKPESARRLPGWTLRAAGRVVVAGVAVALLVVAL
                     SGRDGGRERPVEPPSTSPHPHHS"
     regulatory      24391..24569
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    24721..24735
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            24942..25679
                     /locus_tag="FRZ02_RS30700"
                     /old_locus_tag="FRZ02_30700"
     CDS             24942..25679
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012509.5"
                     /locus_tag="FRZ02_RS30700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30700"
                     /product="hypothetical protein"
                     /protein_id="WP_249639125.1"
                     /transl_table=11
                     /translation="MGFTPGAAPQERTGLRPKAAEAARLFLDHHGLAPPSGTWSHQSEL
                     RVGVGMASSTADIVATLRCLHTYLGIPYDLDTVLRVLSSIERADSVFLDEFALHLSNRH
                     RIVRRLGTALRFHTAYITEPGVVDTEAVTRTLQQFYRRRPDAYGQALTGLLDGFSARDP
                     VAVARASTQSAALSQEVLPKETFETVLAHQGRFGADGVFVAHTGCLVGYLFCRPFSGRT
                     RSDLTAFFASLGHQCSFAQGGFR"
     gene            25676..26698
                     /locus_tag="FRZ02_RS30705"
                     /old_locus_tag="FRZ02_30705"
     CDS             25676..26698
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891292.1"
                     /locus_tag="FRZ02_RS30705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30705"
                     /product="cysteine synthase family protein"
                     /protein_id="WP_037841386.1"
                     /sec_met_domain="PALP (E-value: 6.5e-35, bitscore: 111.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHPHVADALKVPDLVRLDHGLVLLRFESMKIYSALGAVRHLLDE
                     GVVRPGQTLMDSSSGIYAYALALACHRYGMRCRIVASTTVDATTLAQLEVLGAEVEQVR
                     PSSDLKLDQELRVRRVKEILDRHPDHHWMRQYHDAIHYLGYQEVADRMAEELPGRPLTL
                     VGGVGSGASTGGLAERLRTQDSQVRVVGVQPFGSVTFGSQDHHDPEAIIAGIGSAIPFD
                     NVRHHLYDTVHWMDFTHAMSGAVALLKEHAVFAGLSTGAGYLAATHEARRRPDRVHVVI
                     GADTGHRYVERVYARHAEALDIASLKPDEIATPAAMTMPWSVMAWNRTPAHATHRTEAA
                     "
     gene            26695..27954
                     /locus_tag="FRZ02_RS30710"
                     /old_locus_tag="FRZ02_30710"
     CDS             26695..27954
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891290.1"
                     /locus_tag="FRZ02_RS30710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30710"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_037841388.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.4e-09, bitscore:
                     29.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIVCLELLTFGLGHLVSAADLLDERLVLVTRDPSYYAYELDRLS
                     PGALDVVEADTFDVDRVAEVMRAVPDLRGLVSSTDTWMLVGAELAARFRLPGLDPSVLR
                     LTRDKPSVRNRLQEAGLSRGRALEGFLGAPDAAQLVLKEVGLPAVLKDTAGTGSQNVWL
                     VRDEAELTTALHEATGRSLMGQLFAEPFFTGPVYSAETLTWEGHTRLLGVSSRLMSAEP
                     YFREEITAFPVRFPSRRQEELERWIGQVLRAVGYTDRFSHTEFALTSDGPEVIEINPRI
                     GGALVGEGMCTALGTNVYEAVLETALGRRPGLIDAELPGGPAVAFVLGYPAAPGILTGV
                     AGLDRLPTLPGHPAWYPTKRMGTHIEHLDDSRGYAGIVYAEGETAELATHHAVAAANGV
                     RVVTEAAPGAVRGAPEVSGA"
     gene            27947..29212
                     /locus_tag="FRZ02_RS30715"
                     /old_locus_tag="FRZ02_30715"
     CDS             27947..29212
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020699940.1"
                     /locus_tag="FRZ02_RS30715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_30715"
                     /product="MFS transporter"
                     /protein_id="WP_051701244.1"
                     /transl_table=11
                     /translation="MPDEQTHRPPGLRQTLATLSGPLRFLLFSSFLIPLGSFMVLPFMS
                     VFLHERLGMGLGTVGVVLAVASLVQFSGGVVGGAMAERVGLRRTMVWALVIRAAGFIGL
                     LLALRWPPLAVGALVLTCCGAALYLPANKAYLVNGVDEERRPAFLSAGNAALNAGMAVG
                     PLIAGPFVLSSPGWLFLSVTGLFVMVTVGHARLPTEAAGETGPTVHGTGGLLTGIAGLP
                     FAANALAFYLYFHFQHYLAVYAVERTSSQFYSLVLLLCFVLVIVVQPPASGLIRRMPYP
                     LALAVGFAGLAAGLATLAIGTTWALLAGGALITLGDIVLFLKNDLEALRRSPRSDAVVF
                     GQQRLAAGLGACASGVLGGQLYGLGQGLGDTGWFWLLAAGQCLLLPPLLLLRRPGVRRR
                     PPSDLSKGAMTTDDTNRRVPGR"
ORIGIN
        1 gagcaggggg gatgcggggg aaaggtcagg accatgacag acaccgtcac ggtttcggac
       61 cgccccgccc aacccgtccg ccagctcctc gccgcctccg tcggcaacgc tgtcgagtgg
      121 tacgactggt tctcctgcac gggcacgtcc ggacatacct tctgaccagt aacgttgctg
      181 gccagaaggt atgtccggac gtgcatccgg accgaaggtg tcgccgagtc cggccttctc
      241 cggcagtctc gccgctcacc acttgctgac attggtcacg agctgccagg tccgcgatcg
      301 ggctctggac cggcccagtg accggccccg cgcgcaccgc gcctgctgtg ggcgcccggc
      361 ccagccggac gtcgtccttc cggagagcag caaacgccca cccacgactc ggtcaggccg
      421 cgcccgcggc gggttcgcca cgctccgctt cgccgagcag ccgcatcagg acggcgcgcg
      481 ccctcgcgac gcgggagcgg atggtgccga cggggcagcc gcagaccagc gccacctcgg
      541 cgtacgacat gccgacgagt tgagtcagca cgaacgcctc ccggcgttcg accggcaacg
      601 cgttgagcag ctcctccata gccactccgt cctcgaaacc gaggagtccg gggtcctgtg
      661 tccgctcggc aaccctctgc cagtcctcga catcggcgag ccgcggccgc accgatgcat
      721 agcggtaact gtcgatcacc gcccgccgtg cgatagagag cagccaggca cgggccgacg
      781 accggccctc gaagctgtgc aggctgccga gcgcccggag aaaggtgtcc tgggcgagat
      841 cttccgcggc ttccgggtcg gcaccgagga aggtgacgaa gtaccggacg tcacggtgga
      901 gggcacggaa gaaccggtcg actgctgccg ggtcgccgtc acgcgcggcg agcgcccaga
      961 tcgtcgtcgc tgcgtcgtcg gctgttcgct cggcgcgtct tctctcggat ggtgtcgtgt
     1021 tctcgcctgt tgcgagcagg gcagggctga tcacctggtg tccttctcgg agggccgggc
     1081 cctcggggcc acacgggccc ggcggccgga ccggaaggcg cctcggcacg cgaccgaccc
     1141 ggaacggtgt tggggcagga gtgcgccctc gtcgagaggg acctcctgag tgcccgaccc
     1201 ctacgctgac gcggcgcgtc ccgtgcgggt cggggaacca gctgtctcag agaacagcgg
     1261 ctgttccggg cgggccccga gaagtgatcg cgtgggtcag cagccgcagg cgtgggccgt
     1321 gggggactcg gtggcgacat gccggaacgc gcgcccgcac cggggtttcg ggccggtcgt
     1381 ggagcagtcg cgcggggacg gtcaggcggc tggcgagggc ccgcagaatg cggaacaccg
     1441 cgcgttctcc gtgcgccagc cacaggccgc tcagcagcgc ggccaggatg tgggcggtca
     1501 tcatgcctgc ggaggagaat ccctcgggga caggacctgc gcccgtggcc ggaacgtcga
     1561 gcccgggatg acccaggtga tgcaggtgct cgtgggcggc ggcaacgcct tcggcgtgta
     1621 ccgagtgccc cttcgcggtg gcggcgggcg ggagcagccg ctgtgcgtaa gtgaaccatt
     1681 cgtgcagcgc cagttgggtc gctgccacga cggaggagac aagcagcagg ccgcgctccc
     1741 gcccggccag gcaccaggca atggcggcac cggctgtcgc gccggtgccc agagcccacc
     1801 agggcacggc cgatcccgac atcatgacgt gcgcgagagc tgccaagagc acgcagacta
     1861 gtgcgaacag ggcgcaccgt acggtgcgta acccccggcc gacgctcatg gcggaccatc
     1921 ctcgcgctca cggccgtcca cggacagcga ggcatgagaa ttgcttcccg cgccagtggt
     1981 tcccaccatc cgccgtccgg gaagtatcag cgtccggccg aatcaaccat gccgccggcc
     2041 gtcgcccgtc gggccgaccc gcggcaggta gcgctgtccg agtgcctggc aaggggacgg
     2101 gccgcgtagg cgatccgcac cacgccgtcg tcgtgccggg ccgtcgacgc ttcgacgccg
     2161 aacacctcgc gcatcaccac cggagtgagg acgtcgagga ccgggcccgc cgccactgcc
     2221 cggccgtggt cgaggacgac gatcagatcg cagagccgtg cggcgaggtc gagatcgtgg
     2281 agaacggcga gggtactcac ccctgtggcg cggatgaggt cgaggagttc gaaacgggcc
     2341 cggatgtcga ggtggttggt cagctcgtcg aggaccagca ggcggggctg ctgagccagc
     2401 gcgcgggcca gcagcacccg ttggcgttcc cctccggaga gggaggcgta ctccctcgtc
     2461 gcgaaggcgc tgatcccgca gcggtcgatg gcgtccgaga ccgcttgccg gtctgccgtg
     2521 ctctcgcggc tgatcagcct gtggtggggt gtgcgtccca gctccacgat ctccctcacc
     2581 gacagacctc cgccaccggc cgcgtcctgg agcacggcgg ctgtccggcg ggccgcagtg
     2641 cgcggagcca gtcgccagac gtcgtcctcc cccactctga cgacgccccg ggtggggcgc
     2701 agcgaccggt acacagtgcg aaggagcgtg gacttgccgc ttccgttggg gccgacgagc
     2761 cccaccacgg acccgggcag aacttccagg tcgacccctt ggaggacggg ggtgccctcc
     2821 agttcgacgt gtacctggtc gacagtgagc ttcatgtggt gtccaagctc ttgttgcggc
     2881 gcaggcgcca gatgaagaac ggggcgccga ggagtgcggt gaggatgccg agcggcagtt
     2941 cgttggggcg gatgagggta cgggacaaaa ggtcgacgag tacgaggtag acagccccca
     3001 ggagagctgt gagcgggagc agacgccggt ggtcggcacc gagggtgagg cgtaccaggt
     3061 gggggatcat cagcccgacg aaaccgatgc cgccggccac cgcgatgacg gagccggtga
     3121 gcagggcggt gatgaccagc aggacggcac gcagccggtc gacatccaca cctagtgcgg
     3181 tggctgactc gtcaccggcg aggagggcgt tgagccgccc tccgaagagg ccgagcaggg
     3241 cggtgcacgt caggacgatg gccgcgacga cgggcagttg gccccattgg gctccggcga
     3301 cgctgccgag catccagaac atgaccgtgc gcagctcggt gggggtggcc cagagctgga
     3361 cgaaactggt ggccgagagc agcacgtagc ccaccgcgac gcccgcgagc acgagacggg
     3421 taggggccag gcgcccccgg cggcggccca gagcgaagac ccccgccccg gtggcgagag
     3481 cacccaggaa ggccgctccc gccactccca cgccgccgat gccgatcccg cccagggtga
     3541 tgaccaggac cgcgccgaag gaggccccgt aggagaagcc gagcaccgtc gggtcggcca
     3601 gtgggttggc gacgagggtc tggaggactg cgccggcgac cgccagcccg gcaccggcga
     3661 gggcggcgag caggacgcgg ggtgtacgga agttccacac gatctggtcc agtgccggat
     3721 cgtcggtggc tccctgcccg gtgaggtgat gggccaccac gttccagacg tcggcgaccg
     3781 gtacggtcac cgcgccgatg ctgatcgccg tgatcatggc acccgcgagg gccgcgagca
     3841 gaaccgcgac gcccaaagtg agccggagcc cggtcagagc gcgtcggggt ggagcatctc
     3901 ggcgatcttc tccacggcca cgtcgttgct ggggccgagg tagatcgaat cggacagcac
     3961 cacgtacgcg tcgttcttcg cggccgtcca ctgggggaac tccttgagca gcttcttggc
     4021 gtaggccgtg gggtcggggt cgttgtagct gatgacgacg agggcgtcga tgtcggccgc
     4081 ggcgaccttc tccttgctga ggtcggcgaa ggaacccttg gaggcgttct cgaaggcgtt
     4141 ggtgcctccc gcgcgggcga ggatgtcgtt gtagatgccc ttggcgacga cggagctgaa
     4201 gtcgttgccg cccatgctca tgttggagaa gatcaccatg accttgggct tctccccgcc
     4261 cttgaccttc tccgtcactt ccgcgatccg ccggtcggac tcggcgatga gcttctcggc
     4321 gcgttcgctg acgccgaaga ccttgcccat gtctcgcagc agcctccggc tgtcctccat
     4381 ggtcatcttg gaggtgtcct ggtcgcagcc ctgcggcgag acgtagctgt tggcgccgac
     4441 ctgcttgagc tggtcccggg tggcgaagcc gttcttgccg tcgaaaccgt aggcggtggt
     4501 ggacagaacg aggtcggggc gctgggcgag catcgcctcg cggggtatgt cgaaggcgtc
     4561 gttgagcttg atgtcgccct tcggcaaagc cttgatctcg tccgcccggc ccgggacctc
     4621 ggacttgccg taggtctgct ggttgacgac gatgcggtcc tccaggccga gggcgagcag
     4681 cgtggaaacc tcggcgaccg aggcgccgtt catcaccacg acacggctgg gggccttggt
     4741 gaacgtctgc ttcaccccgc agttctccag cgtcaccggg tacccctcgg ccgacgacga
     4801 ggcggcgggc tcgccggccg ccccggtcgt gccctccgac aagcctccgc atcccgctgt
     4861 caccaggctg atgacggccg tcgctccgag aagggcgatc cgcttggtgg acatgtgtgc
     4921 tcctagttcg ctgccggctc gtcgccgggg ttcgtagcaa gagtcggacg gggcgcgggg
     4981 tcagttcccg gctctcgcgg tccgtggtgg gccggcgccg gcaggtcgcc ctgagccaca
     5041 cagtggtcca gttgccggaa gaaggccgcc ctgtcgatct cctggtgagc cggccggacg
     5101 gaggagtctc ctgccgccaa ggccgcgcgc tcctgatctg cctgaacggt ggtcagggcg
     5161 agaccgtcgt ccgctccggc ccagggcgcg ggcagggagt cgaagaacgt caggaccgcc
     5221 acggcgtccg gggtgtcccg ggggatccgc tgccgccagg cgtccagagg cagggcttcg
     5281 atcgcgtagc cgtactcacg cagccacctg tgcagatccg cctggcgcac cgtgctcccc
     5341 gcgtggtggt ggaccaccgc gacgggttcg tgggcgcctg gtccggtcgc cacgacctcg
     5401 gacgcgacgc ggtcggccgg ggtccacgac tcctccgcga agaggtcggg cacaagacct
     5461 gcgggcactc cggcacgcag aacgatccac aggaagtcct ggcggttgac cctgcctgtg
     5521 ccgacgggtc cgacgacacg gccgagtcgg tggacggtta cgggcagacc gcgctcggcg
     5581 gcctgctcga gaaggtgttc ggaggcccac ttggtctgct ggtagccgta gcgcaaccct
     5641 tcgtggacgg ggaggaacgt ctccttggat tcagcgccgg cggcgtcggg gacgaccgag
     5701 agagtggaga cgtagtgcag cgggacgcgg cgtggggccg cgagccgcag caggtcgtgg
     5761 gtggagtcgg tgttggcagg gcgcagggcg gtgtagtcgc ggacgacgct gaccgccgaa
     5821 ccgttgtgga ggatggcgtc gacggtggag ccgagcgcgt tccatcgctg ctcgctcagt
     5881 ccgagacggg gccgggcgag gtcggcaggc aaggcagtca cgcggcggtg ctggtccggg
     5941 gacagcgtca ggtctgccgc cgaaagggcg gagcgcacac ggtccaaggc cgcttccggt
     6001 cctgcggctc gtacggcgca caccacctcg gcgtccgtgg cgcgcaggag ctgggcgagg
     6061 agatggctgc cgacgaagcc cgtggctccg gtgagcagga tgcgtcgtgg cggccacggg
     6121 gccttccgcg cacccgggcg gaccgccggg tccagcctcg cgtcggcgac cagggaatgc
     6181 gggagtgcgg cgccggccgg ggtctgtgag cccgaggcgg cctcggaact gaggaacgcg
     6241 gcgagggcgg cgggcgtggc gcactggaag agccaggcca gcttcacctc tcggccaagc
     6301 ttcgccgcca gccggttggc cgcctgaatc gcctgtagag actgggcgcc ccgttcgaag
     6361 acatcgtctc gctcgctcag ttcgccggac gtgagaacct gccgccagac gtcggtcacg
     6421 atctcggtca gtgtccgctc cccgtcgggc cctgccggac tgtgctgctg aagaggaagg
     6481 ccggccagca gggcagcccg gtccgtcttg ccggaggagg tgcgcgggag gcggggcagg
     6541 aaggtgaggg acgtgggaat catcggagca ggcagccggg cctggagatg tgcgcgtacc
     6601 gacgacgacg cgggttccgg acctacggcg accaggtgtg ccgtgagcct gcgggtgccg
     6661 tcgggcagca cctgccctgt cacggccgcg tcaccgatgc cagggtggga gagcagggcg
     6721 ctctcgacct cgggcggctg gacacggtgt ccactgatct tgaactcgtc gtccacgcgt
     6781 ccgaggtgac ggaggagccc gtcctccccg agctccacga ggtcgccggt gcggtaggcg
     6841 cggggagcgt ccggcaggcg ctccaggcgg acgaaccgct cggccgtctc cacgggccgg
     6901 ttgcggtaac cgtgggcgag cgcgggcccc aggaggtaca gctcgccgtc gatgagggcc
     6961 acccggctgc ccgggagggg gatcccgatc ggcgcgtcgc ccggggccag gcagggatcg
     7021 ccgaggtccg cggcggtggc gaccaccgtt ccctccgtcg gcccgtaggt gttcaccagg
     7081 cggacgcccg taccgacgca ttcccgccag cgggcagctc gctccggcag ggcggtctca
     7141 ccgccgatga tcaccgtgtg tacggcgcct ggcagtgtgt ccgctcccgt ggacagcgcg
     7201 taggccagtt cgtgccagta cgcggtcggc aggtcgagga cggtgacgga caggcgctcg
     7261 cacgcggaga ggaagtgggg caccgagtcc gtcatgtccg gctcgcggat gaccagggtg
     7321 gcgccggagc acagggtcag aaagatctcc tcgatgctgg tgtcgaagtg cggaggcgcg
     7381 aactggagga cacggtcggt ccgtcctggc ccgtagcgca gccccgcccc ggcgacgaag
     7441 tgagccaacg cgccgtgccc gacttcgaca cccatgggct gcccggtcga gccggaggtg
     7501 tggaggacgt aggcgggttc ttcgggcccc ggggcggaca tcgggggctg tccgtgctcg
     7561 gtacccgtcg aggcgccgag cagcaggatc tcgcgatcat ggaagaggtg ggcgtggcgg
     7621 tgctgggtga tgacgagggc cgggacgctg atcgagagca gagcggcggt ccggtccgcc
     7681 ggggcgtccg gatcgagggg gcagtacacc gctccggcgg ccatgacacc gagcatgacc
     7741 gtgacggcct cgatacctcg gggaagagcg acagccacca ggtcaccgcg gttcactccg
     7801 catccggcaa gacgccgggc gacgtcacga gagtgctcca cgaggccggc gtacgtgata
     7861 ctccgttcgc cctcctccac ggcgaccgcg ccgcctcggc ggtccgcgtg atcggcgatg
     7921 agcgagagca caggccgcgg tgacgcggga agcggttctc cttccagaac tcggatggtg
     7981 ggtgcgggca cgtgtgacgg cagggccggt gcgagtgagg agaggagccg gtcgggttcg
     8041 gcgacggctt cggtcagcaa ctcgaagagc gcacgacggt ggcccttgac ctcgtcgagg
     8101 gtgtagaggc cgggatgggc gtccaccgcg aagcgcaggg agccgccttc ggaacggtcg
     8161 tacacgttaa aggcgaggtc gtcgacggga cccgcggaca cgttgtgcac ggtgcttcgg
     8221 tacccggcga aacgcaggtc gtaggcgaag ggcatgatgt tgacgccggg gccggagaga
     8281 cgtcgccctg cgcccacgag tcgtaggtcg cggcggatct gttcgtatcg acagcgctgg
     8341 tgcggcaggg cggcacgcag ttcacgggaa acagcggagg tcagggtacg caaggtgtcg
     8401 tccgggccga cggggacccg tagcggcagg acgttccgga ccatggcggg cactcgcaga
     8461 gagactgagc cgaaacgacc catcgcgggg acgctgagca cgacctcggg tgcccgggtg
     8521 gcacggtgca ggtgggcggc ggtgagggcc agcaggatct ccgaccagga agccctcagg
     8581 tcccgggcgg ttgcccgcag cgctgccgtg gtcgccgcgc cgaggtccgc cgtgtcccgg
     8641 aggaaggagt gcgccgggag cgcggagtgg cctgcggggg tcgcgacgtc cggtctgtcg
     8701 gcgtaccggt gtagccagta ctcccggtca cgggcgaatt ggtcggacga gcggtaggcg
     8761 gcttcctcct cgcgtacgga ggctagcgtg ccgaatccgc tcgggtccgg ctccgtgcgg
     8821 gccacgaagg cggtgtacag gtccgcgacc cgccgggcga acagggagag gccgaagccg
     8881 tccagcgcga tgtggtgaac gcggtggtac cagagatggc ggtcggcggc cagacggaac
     8941 agcgcgtggc cgaacagcgg gccgtgggag aggtcgacgg gccgggcgat gtcgtcatga
     9001 atccagcgga gggctgccgc gtgggggtcg ggcgccccgg agacgtcggc ggtgtgaaga
     9061 cgccactcgg ggatggccgt gtcgacctgc cagggctgcc ccgtgtcatc cgccacgaag
     9121 acaccgtgca gggcctcggt ctcctcgaca gcctggcgaa gggcggtctc gaagtgatcc
     9181 gcgtcgacgg gcccctcgat cgtcacgtac tcggccgtgt tgtacgcggg gctggaggta
     9241 tcgagctggt gcccggtcca gatgccctcc tgggcgccga gcagcggatg ccggcggagg
     9301 tcttgttcac gcgtcaccac gtcgccctgc ctcccgtcct tcttcctgca gttcggccag
     9361 cagctgccac cagccccgga aggacggcag ctctgccagg tcgatgaagg agacgacgat
     9421 gccgtgctgc tcccagcgct cgacgagcgt gaccagtcgc agggagtcga gtcccgcgct
     9481 gacggggctg tcctccaggt cgacctcctc gggctcctgg tggagcactt cggcgaggtc
     9541 ggcacggaac tgctgaaggg tgagggcgga gggcacgttg gtcctttctc ccgctgaagt
     9601 cgtgatgtcc cggggcaacg gtcagttgac cttgcggtcg gagccgtccc agaaccggtt
     9661 ccgcagttcg cggcggagga tcttgccgct ggggttacgc ggcacgtgat cgatgaactc
     9721 gtacttggcg ggcagcttga acgcggccag ccggggcgtc aggaaggtgt gcaggtcccg
     9781 ggcacgcaaa ggctcgccgg ctcggtcttc ggggaccacg aaggcgtgga cgtactcgcc
     9841 ccaccggtcg tccggcgcgc ccaccaccac ggcctcggcg acaccgggat ggcgttccag
     9901 gacgttctcg atctcggccg ggtacacgtt ctcccccgcc acgagaatgg cgtccttgat
     9961 ccggtcgcgt atgtggacat agccgtcttc gtcgaggaag ccggcgtctc cggtacgtat
    10021 ccagccttcg acgagcgtct cggccgtctt gtcggggaga ttccagtact ccaccatgcg
    10081 tgccggtgtg cccaggcaga cctcaccgac ggctccgagc ggcagtacgg tgccatggtc
    10141 gtcgaccacc ttgacctgga cgcccgggta ggggcggccc gcagcctgca tgagcgacga
    10201 tccgggttcg tgtgctgcgg gcggcaggca gacggccgtg ttgccggtct ccgtgagccc
    10261 gtatatctga gcgaactcgc agcggaacac cgcaaggctc tgttcgagca gggtctcgga
    10321 gatcggcgac ccgccgtaga cgatcttgcg aagggtggcg aagtcggccg gcacgacgcc
    10381 gggccgggtc agcatcatcc ggagcatggc cgggaccacg caggtggtgg tgacgccccg
    10441 ccggcggatc agctcaacgg cttcggccgc gtcgaaggca ggcatcgcca cgacggttgt
    10501 tccggcgttg aggttctggg tcgcccacca cagtccaccg atgtggaagc ccgggatacc
    10561 gatgagcgcc acgtccccgg cctgccagtc gatccagtcg acgtccgcct gcgccatggc
    10621 gtccgcgatg gcgaagaagc tgcggtgggc caggacgacg cccttgggca gccccgtggt
    10681 gccactggtg tagagctggg ccaccggggt gtcacgggtg gcctcgtaca cctcgtcccc
    10741 gccggtggcg gtggccttcc aggtggcgta gccctcggcc gcgtccagga ccacgacgtg
    10801 ttcgggcact gcggagggca taccgtccac gacgcggtgg aactcgtcct cgacgaagag
    10861 gagccgggtg ccggagtcct cgaggatgtg gctgacctcg ggggaggtca gccgccagtt
    10921 gacgggcacg agtacggtgc cggtcttggc gcaggcgaag aggatctcgt agtaccgctc
    10981 ggactccttc ccgaggtagg cgacccggtc cccggggctg aggccggccg agcgcagtgc
    11041 ccgcgcggcg cggctgctct cgcggtgcag atccgcgtac gtgagggtgg cggcgccgca
    11101 gacgaccgcc ggtgtgtctg gctggtgttc ggcgtggaag tgggtggtgt cgacgagtgt
    11161 ggtgagcccg tggtgcagcc gcgcgccttg tcggggcttc tgggggagtt ccatgaaggg
    11221 tgtccgtccg gtaccggtcc gtgtgagcgg gccgggtttc aggtgaagtt gacgaaggcg
    11281 agagtggcgt cgccgtcgca tcggccgccc tgtacgtcgc cgtagcggta ggtggtggcg
    11341 gccatgagga gcggcctgcc gcctggcgag cgccggtcca tcgagcgaag ttccatctct
    11401 ccgtggaagt cgcggggatc gacgggacgc tgaaatcggg aggtgaagcg ggcgatgagg
    11461 atgtcgggca gctggtgcgc ccagaagtcc tccagcgtcc agctctgaag gccggccagc
    11521 agcccctcct tcaccgactt cgccacgagg taatacatca tctggttgta ggcgatgttc
    11581 acctccacgg cgttcagatg gccggtgtcc tcgatgtagc aggactcggg gatcgcgaac
    11641 gcgccctcga cccgcgccag cccgtcgggc aaggcggaca cctcggccgt gaggaggtag
    11701 cggcaatggt ccttgtacgg gacgagcacc cgggacagca gggccttgtc cgtggcgtag
    11761 gtgcggagca cggaggcacc ggtgacggtc atgccttctc cagaccggca tgcagcttgc
    11821 gctcgtcgtg gacggtgacg cggaaggaga cggtcggctc gggcgtggtg gtgtggcggg
    11881 cgcagtggat gaggctgcgg ttgtcccaca ccaggaggtc gccacgttcg aaggtctgga
    11941 gatgaatgtt ctcgtgcccg aagtcgcggt cgagctgccc ggtcgcctcg aagagccgct
    12001 gaagcagcga ttcgccgagc ggctcgccct tctcgtcctc gataccgacg gtgaagccct
    12061 cgctgaggta gagcaccttc tcatcggtca tggggtgggt gaagacggtg ggctggcgga
    12121 cggcgggcgt cttctcctcc acctcctgga tgatctccga cagagggcgg tagacgtcat
    12181 gtgggcgtac cttgaagtac ttgcgtacgg agtgcaggca gcgcgtcccc tcgacctcgc
    12241 ccttgagatc ctcgggaagc ctctcgtagg ccgtgcccat gtcaatgaag tacgtgccgc
    12301 ggttcttggc cggtatgacc tgcgggtaga tcagggtgat gccgaacggg tccggcatga
    12361 actggtagtc ggcgtgccag aacttgccgg tcttcgggac gccgatctgc ctgccgtcct
    12421 cgggaacgtt cgaggagacg aacacctcgg gcacctgcgg gtggtggtac atcggctcgt
    12481 agtacgtctc cgggcggccg agccgccttc ccagctccag gaacgcttgc ggggagagat
    12541 cctggccctt gaggacggcg atcttgcggc ggtagacggt ctccttcaag gccatgacgt
    12601 ctgcgggcga cgcagaggtg tggtcgaagt cctcgacaga ggctccgatg gaggttccgg
    12661 tgtgatgggt gatgcgcatg gtggtgctcc ttgtcatgct ggtggcgagg ccgagttcgg
    12721 tcaggcggtc agatgggcct cgatcaactc cgcggtcgcg cccagcgtga ggccgggcac
    12781 gagctcgctg tcttcgacgg tgaccccgag gtggcgctcg atgtggatgc tgatctcgac
    12841 catcgtcagc gagtccacat cgaggtcctc gtaactcgtc tcggggcgga aacgatcagc
    12901 cggggcgtcg tgcagaccgg aaacgatgga caccagctgc gtgtaggtct cggtcatgga
    12961 gcggcttcct cttcgggacg ggacggttcg acggcgggcg gcaggctggg ccaggtcagc
    13021 aggcaggatc cccaggtgag gccccctccg aagccggtga gcaggatccg gtcccccacg
    13081 cccgacgcac cgtccacgtg gctcctcgcg agggcgagcg ggatcgaggc ggcgccggtg
    13141 tttcccatct cctgaacgtg ggtggcacac cgctcgaagg ggaggccgag gtcggtggcc
    13201 acggtgcgca ggatgcggag gttggcctgg tggggaacga agaggtcgat ctccccgatg
    13261 ctgagcccgg cctgttccag cacggcccgg gcagagccgg ccatcctgcg gacggcgtgg
    13321 cggtagacct ccttgcctcg catggtgaag tgcttctcgg cgtgcgaggt ccgggcaggg
    13381 tcgacaggca ggcgggaccc tccggccggg acggtgatca tgtcctcatg gactccgtcg
    13441 ctgccgaggt cgaagaagcc cagggcacct ggctccgtgt catggccggt gcgcaggacg
    13501 acagcgcccg cgccgtcccc gaacaccacg gcgttctgcc ggtccccggg atccacgatc
    13561 cgggtgtaca ggtcggcgcc gacgaccagg acacgatccg tcacccgtga ggtgatcagc
    13621 cccgcccccg cggccagggc gtagacgaac ccggagcaca cggcgcccac gtcgaacgcc
    13681 gcgactccgg tgagaccgag ccgggcggcg accagcggtg cggtggccgg gcaggtgcgg
    13741 tcaggcgtcg tcgtggccac gatcacggcc ccgacggtgg ccgacccgga gttggcgagt
    13801 gctctgcgcc ccgccgcgac ggccaggtcg gaagtggcct cgtccggcgc ggcgaaatgc
    13861 cgggcccgga tgccggtgcg ggtgcgtatc caagcgtcgt cggtgtcgag ctggtccgcc
    13921 agctcgtcgt ttccgacctt gagccaggga agctggccgc cgacgccgca gaggactgcg
    13981 gcacgagagg gcctttgggg ggatgttccg agcatggttc tcctggcgga cggtgtcctg
    14041 ggtgatgagg tgttcgttca ggcggcggca cggctccgtg gcacgaagag gaggagcatg
    14101 ccgagggtca acgccccgga ggtgagaagc agagccaccc gcatgccgtc gaccagtacc
    14161 gggatcgacg actccgctcc gatgcccgac gccgccgcca ccagcagcgc gagtccgaca
    14221 gccccgccca cctgaagaga agtggacgcg ataccggaag ccatgccctg gtcgcccggg
    14281 gagatcccac gggccgccgc tatccacaga gccgtccaga ccgccccctg ccccaggctc
    14341 gtcaggacga tcccaggcac cagcacgccg tacgggctct gcgccgagac agcggggacc
    14401 aaggcgagcg tgccggccgc gccggcgccc aggccgccgg cgagcagcgg ccgcacacca
    14461 aaacgggaga ccgccggggc tccggcctgc gttcccgccg cgacgacgag tgccgggagg
    14521 aggaagcaga gcccggtggc gagggcgtcg tagccacgca cggtctggaa gtacaacgtc
    14581 aggaagtacg gcagtgaact gaacgtagcg ctgaagagtg cggccagagc agcggccgct
    14641 gccaggcccc ggtgccgcag gaggcggaca ggcaacaggg gacccggagt ccttgcctcg
    14701 atgacgacga ggaggaacag gctgaggagg gcgagggtgc ccgcaatcag ggcggccggg
    14761 cgagtccagc cgacggcggg ggcgtacacc aggaggaaga cgagggaggt gaggcccgcg
    14821 gtcgcggtga gcgacccggc gacgtcgaaa cggcgcctac ggtcggggac cgggtcgacg
    14881 gcgaaaacga accggccgag gacggcaagg gcgagcgcga cagggacgtt gacgaggaag
    14941 accgagggcc atccgtagct gtggaccaga gcaccaccga ggagcgagcc caggcacaga
    15001 ccgccggctc ctgcggcgcc ccagagcgcg agcgcccggt tccgcgacgg cccctccgcg
    15061 tacgtcgtgt tgatgagcgc cagagtggcc gggaagagca atgcgccccc cagtccctgg
    15121 gctgcgcgta cgcagagcag gacgcctggc gactgagcga ggccgcccac cagcgaggcc
    15181 aggccgtaga ccgaggtggc gacgacgaac atgcggcgtc gtccgagcag gtccgccgct
    15241 cgtccgccca gtagcaggaa gcctccggtg gccacgacgt aggcgctgac cacccattgg
    15301 aggtcgtggt cgacgaaccc cagcgatgca ccgatctgcg gcagcgccac gtagacgatg
    15361 ctgtggtcga gggatatgac cagttgggcc acggccagga cgaccatggg gaggccgaga
    15421 cggcggcgta ccgccgctgg cccggctgtg gtgacggaca tgatcgtccc cttcggacgg
    15481 atgggacagg tcggtctgcg ggcgccctga gcacgcagga gcgcagatgg agggcgtcgg
    15541 tgcaggcctc acgccgccac gacgatgccg tcgggtcggc cgacgggact gcggggtggg
    15601 ggccctgtcg tggagaacgg gcgggtcacg tcccggagag cgaccgcctc acctctgtga
    15661 ccaggatcgt cagtgcctgt cgctcaggga cggtggtctc cgggtgccag aggtcggcca
    15721 ggagacaggt ccgggggcgc gggccgcggt tctccgcgtg gtgctcgaag gagtagtcga
    15781 agagcagaca acgaccttcc tcccaggtac gggtttcacc gccgacggtg atgtcgcagc
    15841 catcggggat gtccaccgcg aagtgcagat tgatgctgaa gttccagagg tcgcagtggg
    15901 gtgcgatgcg cgcacccggc aacagggtcg agaagtggct ttccagcaac gggcagatca
    15961 gaccgcgtgc gaccgccacg tccctgatga ggccgaaggc ggtgggagcg atctcggccg
    16021 cgtcggccac gagcccgccg tcgcggtaga gatggagcga ttgccagtcc tcctgccggg
    16081 tcaggtagtg ctcgtactgc gagaaggccc ccggcttcgc ccgccaggcc ctctcgtgct
    16141 cctcccggat cgcccggtgg ccaccttcca gagcatcgac gaacgaggcg atctccggat
    16201 ttcccctcgg gtcgtgccac ggctgctgcg atatccccgg aagaatccac ttcgcgccgg
    16261 cttgcatcgc atgtctggag cggccccccg aattcatcat ctcctccacc cgccgaagcg
    16321 aatggggacc gaactcctcc cgtatggcgg cgaaccgctc gtccgtcgac tgcatgacgc
    16381 atccttctcc gctctgccac aggacatctc gcggcggccc gactcccgca cttcgaactc
    16441 ggagcctcga ttgccgctac gtatcaatag tcgagaggag gtgattccga gttcccgtcg
    16501 tggcggaaaa attcggctgg atttcgatga gctcgtccgt gatgccgcga ggacgttcag
    16561 tgcgggccga cgagaccgag gagggcgtcg tacacctcgt ccgatgccgc gtccctgctt
    16621 cccgcctcat aaggcggctg cggggcatac tcgatcagaa gctgcacggc ctgcgccacg
    16681 cggtcccccg cgatcagacc ggccagagtc agcgccatgt cgatacctgc cgagacgccc
    16741 gctcccgtgg cacagtgccc gtcgatgacg accctttcct tcgacggcgt cgccccgaac
    16801 tcggcgagct gttccagcgc gccccagtgc gtggtggccc ggcggccggc gagtacgccg
    16861 gcggctgcca ggatcaggga gcccgtacag acggaggtca tccaggtggc ggacgagccc
    16921 actgcccgga gccacgcgtg cagagcaccg tcggccatct gatcggcctg accggcgccg
    16981 ccaccgacaa ggacgacgtc cgggttcggc acctcctcga aaccgtgcac cactttcacc
    17041 gagaggcttc ccagatcgtt gaggacgagc cccggattct cggcgacgaa gaagacgtca
    17101 gcccccggaa ggcgggctaa tacctcataa gggccgacga cgtccagtgc cgtgaatccg
    17161 ggatagagaa cgatcgcgat ctgcatcaag ggccttcttt cgactgatca tgaaaataag
    17221 ggcgcgcgaa aagcaccacc gtcaccgcgc tctcacagcg tggcgtcgca cccctgacag
    17281 gcacgtctcc tcgggattca gaaacacctc cacgtgaaca gtcggtcggg tgcgcacccg
    17341 agttcccgtc aatcacgaga agaatgggcg cgaatcgatg tgcccgaggg acggcgttcg
    17401 aggcctcaga acccggagcc cagcgtgacg ggccggacga ccgcctgaac ggtcatccgc
    17461 ccggatcgtt cgaggtcgag cgtgaacgtg acgcggtctc cggggcgcca tgcccggtcg
    17521 gcacggaggt tcacagcggt cgagtgcggc gacatcctga cttccccgtc ggccgggacc
    17581 gtcacggtct tgacgggctc acggtatgca ccgttggcat cgttcattcg atgctcggtc
    17641 agctcgggct cggccgcccc ggacgatgtg acggcgcgga gcctgtccgg cgccccgccg
    17701 ctgttcacca ggtggaagta ggcgttggtg tttccgccgg gcgtcaccgg cagcaggact
    17761 ctggcctgct tcacctggac gtcggccgga gtacccgcgt agccggctga ggcccatgtg
    17821 gccagacctc cgacggcgac gagcgaggcg gcggccacca ttgctccggt cctgccggct
    17881 tctcgtacgc gggcgaggca gtcggggcct ggggaatttc tcttcatgag ggcgttctcc
    17941 acgaggaagg gcgagcggac ctgtacgcgg cccgacggcc tgagccggaa gcatgctgga
    18001 gggtcacgcg atgctccgcg gccgcggcgt ggcacgcacc cctgggccgg ggtgcgtcga
    18061 gggccgccag ctgcggagac ggaggctgtt gaccacgacg aggaccgagc tgagcgacat
    18121 cgctacggct gcgaccatcg ggttcagcag accgaccatg gccagcggca tggtcacgac
    18181 gttgtagccg aatgcccaga cgaggttggt gcggatggta cgcagcgtgt gccgcgccag
    18241 ccggaccgca tcggcgagag cttcgacgtc gttgcggacg agggtgacgt cggaggcgcc
    18301 gatcgccgcg tcggcgcctg taccgacagc gatgcccagg tcggcgcagg cgagcgccgc
    18361 agcgtcgttg actccgtccc cgaccacggc gacccgtcgt ccctcggcac gtagccgtcg
    18421 caccagttcg actttctcac caggcgtgca gcgtgagtgg acctccgcga tgccgaggtc
    18481 ttccgcgacc acccgcgcga cagcggcacg gtcgcctgtg gccaggaccg ggcggatacc
    18541 gagccggcgc aaccggtcga cagcacggta gctgccgggg cggacaagat cggagacctc
    18601 gacgactgcg gtcggcgtgc cgtccacccg cacgagtacc gccgtgcgag ccctctcgtc
    18661 cgcccgccga caggctgctg cgagcaccgg cggcaaatcc gaggagtcgg gggccaccac
    18721 ctccacctcg tgtccttcga cggtcccgct cacgccgtgg ccggcgatgg accggaacgc
    18781 cgtcacgtgc ggcagtgcct cgtcagcggc ggcacggcgt gcgtggaggg acagcgcccg
    18841 gcccagcgga tgctccgatc cgtgctcgac ggcgcctgcc aggcgcagga cgtccggttc
    18901 cgtcagctct ccgccggcca cggtgacccg cccgacggac atgtgccccg aggtcagggt
    18961 tccggttttg tcgagcacca cggtatcgac gtgctgaagg ccctccagcg catgcgctcc
    19021 cctgaccagc acacccagct gcgccccacg accggtggcc gccatcaggg cggtgggtgt
    19081 cgccaggcct agcgcgcacg ggcaggcgac gaccagcacc gcgacaccgg ccgtgaccgc
    19141 cgcctgggcg tccgcaccgg caccgagcca gaagccgagc gtcgtggctg cgagcgccag
    19201 gacgacgggg acgaagagac ccgcgacggt gtcggccagc ccctgggccc gcgcctttcc
    19261 tgcctgggcc tccatgacca gctgcgtgat ccgggcgagc tgggtgtccc tgccgaccgc
    19321 cgtcgcgcga accaggagca ggccgcccac attgaccgat ccgccggtca ccggactgcc
    19381 cggccccacc tcgacgggtt ccgactcccc ggtcaccagg gagaggtcga cggcggagct
    19441 gccctcggcc acctctccgt ccgtggcagc gcgctcaccg ggacggacca ggaacacctc
    19501 gccgaccatc agccgttcga tgggcaccag ctcgtccaca ccgccacgcc gtaccgtcac
    19561 caccttcgcc gcgagacggg cgagcgaccg cagggccgcg cccgtccctc gccgagcccg
    19621 gccctccagg taccgcccca ggagcacgaa gagcggaacg cccaccgccg cttcgagata
    19681 gacgtgtgcc atcccgtcgg acgccgaggg caccaggctg aacggcatcc gcatgccgac
    19741 agccccggcc ccgcccagaa agagcgcgta cgacgaccag cagaacgagg cgaccactcc
    19801 cagagaaacc agcgtgtcca tggtggcggt ggcgtgcctg atgccgctca gagcacggcg
    19861 gtgaaacggc caggcacccc aggtggcgac cggcgcggcg agcatgaagc acagccactg
    19921 ccagttgtcg aactgcagcg ggggcgccat cgacaggaca aggacgggca gtgacagagc
    19981 cgcggtgacg agcagtctct cgcgctcctg ccgggtatcg tgcgcggccg gtcccgctct
    20041 tccgtcgggc cgttcctgag cctccggagc tacctggcgc actctgtacc ccgcggcctc
    20101 gaccacggct gtcagctcac cggtggtcat ccctgcaggg tggctgaccc gggcccggcc
    20161 cgtggcgagg ttcacctctg ccgtgacggc ctccagcctg cccagtttcc gttcgacccg
    20221 ccggacgcag gccgcgcacg tcatcccgtc caccacgagg tccgtgacca ccctcgtgtc
    20281 cgccgtctcg gccgtcatca atgaccgcct ccgtggtgca tcggcgcgtc ctgctcaccg
    20341 ggcggtgtgc cgcccgtgat cccgggcgcg tgcatgccgg gcgcgacggg ccccaccgcg
    20401 ttccccacca cgtaggcgcc gacgaagagc gcccccagca gaaggaggaa tccccacagc
    20461 gcggggggcg gtacggaccg gacagttccc gctcgggtca cgggggtgac cgtcagttcc
    20521 acggagtact cctcgacgtt ctcggcgcga gccgtgaaag ggtcgacggc tcgtggcgac
    20581 tcagaagtcg atcgccacct cgtccgagtt ccccggcctc gaggtgaagg gcgtcacagc
    20641 actcgttcgg gtgatcggga aaggccgcga gggcagcgca gcgcctctcg cggccgtccg
    20701 gggcggctgg gccaggcctc gggttcagcc accccggaca ccggtcagct caccggccgc
    20761 tcttcccggg accgtcgggc ccggatcccg agcagcacat cgatcgccag gaagaccagc
    20821 aggctgatgc cgagcagagg gaggaaccac ccgacgaagg ccaccacggc aatcagcggg
    20881 acgagcagac cgacaggcag agcgcggagc ccgcccctgg gcatcggtct gcccaccgtg
    20941 cgccctgctg gacgccggag ccaccacatg cgatagcccc acacgatgag gagcagcagc
    21001 actcccacca gcgccgccag ggcgagctga ttcggcaggc cgaacaggta ccccatgtgc
    21061 gcgtcgatgc cgaaccgggt cagcttggcc agcagggggt agtcggcgaa acgcagctcg
    21121 gacaggatct caccgttccg cgggtccacg gagacggcat ccagatgcac ggggacctgc
    21181 ttgtcggact cagcgacctt gtacccctgg ccgtccgtgg gcatcgtgac gacgacgccg
    21241 gcgtccaccc cacgggccgc cgcggccgcc acggcggcgt ccaggccgac gtccgggccg
    21301 ctagcctcgg atccgcccgt gtgctggccg ccgtgacctt cgtgtcccgc gtgttcgtcg
    21361 tgggcaccgc cctcctcccc cggggtgagc tcggcaccga gcacaggcgt cgctccgccc
    21421 aggccgtcct gcaccgcgcc gatccgggca ccggcgtacg tggaccaggt cagccccgtg
    21481 gcagagatca tgatcagccc caccgcggcc cagacaccga ggacagcgtg ccggttcaac
    21541 gtgcgggagc ggcccttgtc cattcctcgg cgcggcagga ggaaaccgcg tgcgcccggc
    21601 ctgccgcgcc ggcgcccgat ccagagcatg acgcctccga ggacgaccac ccagagccag
    21661 ctcgcggcca gttcgctgta gatccgcccg ggttcgccca ggtgcaggtg gcggtggaac
    21721 tcggatatcc aggtgcgcag cgggagcgcg ccggagctgc cgtactggac cagctccccg
    21781 cggacctccg cggtgtaggg gtcgacgaag accgcctggg acttggaggc ccccagcgac
    21841 gggtccgcga agagcacccg ggtggtgtcc tcggcctcgg cgggagccca gaccgacgtg
    21901 acctcaagct cagggtgagc tgcccgcgct gcctccacct gctgttccaa cggcagacgc
    21961 gtgccgttct cgggtgcgga gacgctcaac tcgtgctggt agacgagctt ctcacctggg
    22021 atcgacagcg cgtagagcat tccgctcaag gctgtgacca ggaggaacgg agctaccagc
    22081 aggccggcga agaagtgcag gcgcagcacc aggggccgca gcgcggacca ggcactcgtg
    22141 cccgggggtt tctgcggtac gcgctcggcc acggctttcg gtggggcggg acgggcgtcc
    22201 gggacgccgg tggtgtcagt catgtcgtat ccctgggggg cggcacgccg gtgtgggagc
    22261 acactggctg cccgcgcggt ggcgggtgcc ggggtggagc cggttcgccc ggccccctgg
    22321 gtcagggaag gacgagacgc ggcggggtcg gtgcgatgcc ggcctccgga acgcggtggg
    22381 aagcgtccgc ggggcggcgg gggccggccg gtggaccgcg tcgcgtgacc acgtgcccga
    22441 gtacgaggtg accggctgcg ggagcggacc ggggagccgg gaagctacgc ggccggacaa
    22501 ccactagggg cgccggaagc ggtatgcgga aggtccggac gaactccgcg ctcgccgcgt
    22561 gagccagctg cgtcagtgcc cgctctccgt gggacagcca ccaggcgcag cccagggccg
    22621 cgagaaggtg ggcggcagtc atggaagagg tgtcgccggt cgccagcgtg tcccaggcgg
    22681 aggggttcgc cgcgtccggc atcccggccc ctcccatgtg cgcacctggg tacgcgtggg
    22741 aggacgagcc cggttcagga acggtgtggg cccagctgaa agccgcgtgc agcagaagtt
    22801 gggtgccgag cgtccccgcg cagatggcga ggggtccgcg ggcccgtccg gcggcgaacc
    22861 acgcggccac gacgatcgac cagaacgccg cgaccagcac ctccggggag accgcatgcg
    22921 cggaggagag cgcgtggccg ctccccgcga ggctcacgca caccaacgcg aagaggaggg
    22981 cccgcacggc acgcacaagg ctctcggtgt ggctcacagt cggccatggt gacagggaag
    23041 ggcgccttcc gcatcgatgc gaacccgtca tatgccgctt tgtccacgag tctgtcgcaa
    23101 gccacacacc cgggaaccgg agcacggcgt gagccgtacg agccccggca cggcgacggt
    23161 cgccacccat tcgccaggac cgatcagctg tggtgcggat gcggactggt ggagggaggc
    23221 tccaccggcc gctcgcgccc cccgtcccgt cccgagagcg ccacgacgag cagcgccacg
    23281 gcgacaccag ccacgacgac acggccggcc gcacgcaacg tccaccctgg aagccggcgg
    23341 gccgactccg gtttgcccag gcgttcactc cgtcgcgccg gcccgaccag ccgggcaagc
    23401 agcaggacgg cgaccgggat ctggagcagc cagagcacag tgcgcggcca ttctccgtac
    23461 cagacgttgg tgccgtacag cagcgtgtgc cagacgctga gcacgtagac gacgatcacg
    23521 aagcggtgca gaacccgcca agtcctcgct ccgatgcggt ggcgcacgta gaagagcagc
    23581 cccagcggca cggccaggta gagagcggcc tgcccgatgg ggatggcgat ctggcctgtt
    23641 cccgagtcgt accagccggg gacgaaggag tcggcgaagg ctgcccacag tcgttcggcc
    23701 cagccgagct gtgcctcgta ccggaccagt tccgcggcga acatgagggc gtgcgccagc
    23761 atcagcgcca tcgtggtgag gctggtcgtg cggtgccagc gctccagggt ctgcggcgag
    23821 acgcgcagcg cttcgggcct ggtgccggag accagcagtc cgatcatcac cgtcccccac
    23881 gcccacaaca gggcggacca gccgaacgcc tggctgagca ggtacatcca gtacgtgcgg
    23941 gggtcgtcca tgaagggcat gaccgcgacc gtcgcggagg taccggactc catccggacg
    24001 tacaggaaga cgaagacggc ggcggtgacc ccgaccgcgg cggcggcgtc cggcagggcg
    24061 aggcgaagat cgccgcgaag ggtgacgcgc cctcccacac ggctccggtt cttaccggag
    24121 cctctctccg tctcgtcctg ggaagccgtt tctggcgaca aggcgaagcc tccagggtcg
    24181 gtcaccgagc gctcggtgag gtcgtggggc ccagtgtgac gggacaggcc agtcggacgc
    24241 agtcgttttc cggccacaga tcaacactgc tgtctcacgt gtgtacttcc gtaccgctcc
    24301 tccctccccc accactcaca tcaggacacc gctgaaccgc cccctgtcgc atcggaggca
    24361 ccgcgtctac gctgacgctg cgatcggtcc gtaccaagtg accgcactgg tgcggcgtaa
    24421 gagggaaccc ggtggaaatc cggggctgtc ccgcaacggt gtgcgagaac ccccgaactc
    24481 cgacgtcacg cacctggcct ccagccaggg ccgaggcgcc atgggacttc tcgcaagccc
    24541 ggtcacctgc cggccgcacc cgcccgaagt tgtctggcgg gtccgaccac tgcgacctcg
    24601 aggaccgggt cgacggtcac ggcgccttcg cggcgagcgt gccgcggcct gtcctcctcc
    24661 tcgcccgtgt ctggtgcacg gcgccggaag gagagcgaat ccgtgtccct ttttcgccac
    24721 ttctccttga gcgaagaccc cgccgtgtcc cgtcggccgg agggaggccg acggtgctga
    24781 actccttacc ggaggtcctt gagaaccacg ccccgcgctc gccgacggtc tggggagcgt
    24841 gccatgggac cctcggcgag ctgtaccaag gccccctgcc ttccggcgat gactccgaca
    24901 tcgccctggt ctcttttccg gtacacggtc tgaccgcccg agtgggcttc accccgggcg
    24961 ccgccccgca ggagaggacc gggctccgcc cgaaggcggc cgaggcggct cgcctgttcc
    25021 tggaccacca cggcctggcg ccgccgtcgg ggacctggag ccatcagtcc gagctccgtg
    25081 tcggtgtggg gatggcgagt tcgaccgctg acatcgtggc cacgctgcgc tgcctccaca
    25141 cctacctcgg catcccctac gacctggaca cggtgctacg cgtcctctcg tcgatcgagc
    25201 gtgccgacag cgtcttcctc gacgagttcg ccctccacct gagcaaccgg caccggatag
    25261 tgcggcgcct gggcaccgcg ctgcgtttcc acaccgcgta catcactgag ccgggcgtgg
    25321 tggacaccga agcggtcacg aggacattgc agcagttcta ccgccgaagg ccggacgcat
    25381 acggacaggc tctcaccggt ctgctcgacg gcttctccgc tcgcgacccc gtggccgtcg
    25441 cccgcgcctc gacgcagagc gcggcgctct cccaagaggt actgcccaaa gagaccttcg
    25501 agacggtcct cgctcaccag ggacgtttcg gagccgacgg cgtcttcgtc gcccacaccg
    25561 gctgcctggt cggatacctc ttctgccgcc ccttctccgg ccgcacccgc tcggacctga
    25621 cggcgttctt cgcgtcgctg ggccatcagt gctctttcgc ccaaggagga ttcaggtgat
    25681 ccacccccat gtcgccgacg ccctgaaggt gccggacctg gtgcgcctcg accacgggct
    25741 cgtactgctc agattcgagt cgatgaagat ctactccgcc ctgggggccg tgcgtcatct
    25801 gctggacgag ggtgtggtcc ggcccggaca gaccctgatg gacagctcca gcggcatcta
    25861 cgcctacgcg ttggccctcg cctgccaccg ttacgggatg cggtgtcgca tcgtggcctc
    25921 caccacggtc gacgcgacga ccctggctca actggaggta ctcggtgcgg aggtggagca
    25981 ggtgcgcccg tccagcgatc tcaagctcga ccaggaactg cgcgtacgac gggtgaagga
    26041 gatcctggac cgccaccccg accaccattg gatgcgccag taccacgacg ccatccacta
    26101 cctcggatat caggaggtcg ccgaccgcat ggcggaagaa cttccgggac gcccgctcac
    26161 cctcgtcggc ggcgtcggct cgggcgcgtc gaccggcggg ctggcggagc ggctccgcac
    26221 acaggactcc caggtccggg tggtgggagt ccagcccttc ggcagcgtca ccttcggcag
    26281 ccaggaccac cacgatccgg aggccatcat cgccggcatc ggctccgcca tcccgttcga
    26341 caacgtccgg catcacctct acgacaccgt gcactggatg gacttcaccc acgccatgtc
    26401 cggcgccgtc gcgctgctga aggagcacgc ggtcttcgcc gggctgtcca ccggggccgg
    26461 ctaccttgcc gccacgcacg aggcccgccg ccggccagac cgcgtccacg tggtcatcgg
    26521 tgccgacacc ggccaccggt acgtggaacg cgtctacgcc cggcacgccg aggcgctcga
    26581 catcgcctcc ctcaagccgg acgagatcgc gacgcccgct gccatgacca tgccctggtc
    26641 ggtcatggcc tggaaccgta cgccggcgca cgccacacac cggacggagg cggcatgagc
    26701 atcgtctgcc tggaactgct caccttcggg ctcggacacc tggtcagcgc ggccgatctg
    26761 ctggacgagc gtctcgtcct ggtgacgcgg gacccctcct actacgccta cgaactcgac
    26821 cgactctctc cgggggcact cgacgtggtc gaggccgaca ccttcgacgt ggaccgggtg
    26881 gccgaggtca tgagggccgt gccggatctg agaggtctgg tcagctccac ggacacctgg
    26941 atgctggtcg gcgcggaact cgccgcacgt ttccgcctgc ccggactcga cccctcggta
    27001 cttcgcctca cccgggacaa gccctccgtc cgcaaccgcc tccaggaagc cgggctgtcc
    27061 cgaggccggg ctctggaggg cttcctggga gcgccggacg ccgcgcagct cgtcctcaag
    27121 gaggtcggcc tgccggcggt cctcaaggac acggccggga ccggcagcca gaacgtctgg
    27181 ctcgtacggg acgaggccga gttgacgacg gcactgcacg aggccaccgg gcgcagcctc
    27241 atggggcagc tcttcgccga accgtttttc accgggccgg tctacagcgc cgagacactg
    27301 acgtgggaag gacacacccg gctgctcggc gtctccagtc ggctcatgtc cgcggaaccg
    27361 tacttccggg aggagatcac ggcattcccg gtgcgcttcc cgtcgcggcg ccaggaggaa
    27421 ctggaacggt ggatcgggca ggtcctccgg gccgtggggt acaccgaccg gttctcgcac
    27481 accgagttcg cgttgacctc ggacggtccg gaggtgatcg agatcaaccc gaggatcggc
    27541 ggggcgctcg tcggtgaggg catgtgcacg gccctcggta ccaacgtcta cgaagcggtg
    27601 ctggagacgg ctctgggccg gcgtcccggc ctcatcgacg ccgaactccc aggcgggccg
    27661 gccgtggcct tcgttctcgg ctatccggcc gctccaggaa tcctcaccgg ggtggcgggc
    27721 ctggacaggc tgccgacgct gcccggccat cccgcctggt atccgacgaa gcggatgggc
    27781 acgcacatcg agcacctgga cgacagcagg ggatacgcgg gcatcgtcta cgccgagggg
    27841 gagaccgccg aactcgccac gcaccacgcg gtcgcggcgg cgaacggcgt ccgggtcgtc
    27901 accgaggcag cgcccggcgc cgtccggggc gctcccgagg tgtcgggtgc ctgacgaaca
    27961 gacgcaccgg ccaccagggc tgcgacagac actcgccacg ctgagcggac cactccgctt
    28021 cctcctcttc agctccttcc tcatcccgct cggaagtttc atggtgcttc cgttcatgtc
    28081 cgtcttcctg cacgagcggc tgggcatggg cctggggacg gtcggggtgg tcctcgcggt
    28141 cgcctccctg gtgcagttct cgggaggggt ggtcggcgga gccatggccg agcgggtcgg
    28201 gctgcgccgc acgatggtct gggcgctggt gatccgcgca gccggcttca tcggcctgct
    28261 cctcgcgctg cggtggccac cccttgcggt gggcgctctc gttctcacct gctgcggtgc
    28321 ggcgctctac cttccggcca acaaggccta cctcgtgaac ggggtggacg aggaacgccg
    28381 cccggctttc ctgtcggcgg gcaacgccgc tctcaacgcc ggcatggccg taggcccgct
    28441 gatcgccggt cctttcgtcc tctcctcccc cggctggctc ttcctctccg tcaccgggct
    28501 gttcgtcatg gtcacggtcg gccatgctcg tctgcccacc gaggcggccg gggagaccgg
    28561 ccccaccgtc cacggaacag gcggactcct cacagggatc gcgggcctgc ccttcgccgc
    28621 caacgccctt gccttctacc tctacttcca cttccagcac tacctggccg tgtacgcggt
    28681 ggaacgcacc tccagccagt tctacagtct ggtcctgctg ctctgcttcg tcctcgtcat
    28741 cgtggtgcag ccgccggcct ccggcctgat ccgacgcatg ccctaccctc tcgctctggc
    28801 ggtcggcttc gccgggctcg ccgccgggct ggcgacgctc gccatcggca ccacctgggc
    28861 gctgctggca ggcggcgctc tcatcacgct cggcgacatc gtgctgttcc tcaagaacga
    28921 cctggaggcc ctgcgccgca gcccccgctc cgacgccgtg gtcttcggcc agcaacgact
    28981 ggccgccggc ctcggtgcgt gcgcgagcgg tgttctcggc ggacagctct acggcctggg
    29041 gcaaggcctc ggtgacaccg gatggttctg gctcctcgcc gcagggcagt gtctcctcct
    29101 tcctcccctc ctcctcctgc gccgccccgg tgtgcggcgg cgccctccgt ccgacttgag
    29161 caaaggagca atgacgaccg atgacacgaa ccggcgggtt ccaggacgat gacttctgga
    29221 cggagtttca cgacttcctc ttctccggtc aacgctacgc acaggccgag gaactgctcg
    29281 acaactcccc gttgctgcgg ttcccggaag gcgcgcg
//
