LOCUS       NZ_VOGX01000054        27133 bp    DNA     linear   CON 15-OCT-2024
DEFINITION  Streptomyces albidoflavus strain 77 scaffold22_cov50_245018_832312,
            whole genome shotgun sequence.
ACCESSION   NZ_VOGX01000054
VERSION     NZ_VOGX01000054.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 587295)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Draft Genomic Sequences of Streptomyces misionensis and Streptomyces
            albidoflavus, bacteria applied for phytopathogen biocontrol
  JOURNAL   Microbiol Resour Announc (2019) In press
REFERENCE   2  (bases 1 to 587295)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2019) Biology, UFLA, Universidade Federal de
            Lavras, Lavras, MG 37200000, Brazil
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-JUL-2019
            Assembly Method                   :: SPAdes v. 3.12
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 36.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007896905.1-RS_2024_10_13
            Annotation Date                   :: 10/13/2024 04:20:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,551
            CDSs (total)                      :: 6,456
            Genes (coding)                    :: 6,343
            CDSs (with protein)               :: 6,343
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 5 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 34 of 113
            Pseudo Genes (incomplete)         :: 81 of 113
            Pseudo Genes (internal stop)      :: 8 of 113
            Pseudo Genes (multiple problems)  :: 8 of 113
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:41:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 560162
            Orig. end                         :: 587295
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VOGX01000054.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27133
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NI-siderophore"
                     /region_number="2"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..27133
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27133
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[14000:15821](-)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(14001..15821)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     misc_feature    28..43
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.86"
                     /tool="antismash"
     misc_feature    complement(559..572)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(845..1891)
                     /locus_tag="FRZ02_RS26865"
                     /old_locus_tag="FRZ02_26865"
     CDS             complement(845..1891)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468241.1"
                     /locus_tag="FRZ02_RS26865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26865"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_003948203.1"
                     /transl_table=11
                     /translation="MASEFSAAAPSSVEEGAAAPASGVAVASGPPQDPGREAADRRRER
                     RSRWYRRDVKWSPYAFIAPFFLFFAAFGLFPLLYTGWASLHRVELTAPNDMEWIGLRNY
                     TRLLDDEFFWNALQNTFTIGILSTVPQLLMALGIAHLLNYRLRGSMFFRVAALTPYATS
                     VAAATLVFVMLFGRDYGMINWFLSLAGFEHIDWQNGSFTSQLAVSSIVVWRWTGYNALI
                     YLAAMQSIPADLYESAALDGASRWQQFLHVTLPSLRPTILFTVVVSTIGAIQLFGEPLL
                     FNGGGGATGGSEHQFQTLGLYLYEQGWTNLHLGRASAIAWAMFLLLIVIGLVSLAVTRW
                     LRRGEGKA"
     gene            complement(1898..3235)
                     /locus_tag="FRZ02_RS26870"
                     /old_locus_tag="FRZ02_26870"
     CDS             complement(1898..3235)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894991.1"
                     /locus_tag="FRZ02_RS26870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26870"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_018894991.1"
                     /transl_table=11
                     /translation="MRTMRTRSRTARKAVVLAAVAALGTSLLAGCASDDEPEAAGGDAG
                     SDQGKTTLTVGVFGAFGLKEAGLYDQYMKENKDVVIKQTSIERNENYYPQLLTHLGTGS
                     GLADIQAVEANNIAEIVQTQGDKLEDLSKAPGADKAAFLEWKWAQGTTEAGKTVGLGTD
                     IGPQGICYRKDLFEKAGLPTDREEVGKLWAGDWDKYLEAGKEFQKKAPKGAKFVDGAPG
                     VMAAVTGSSETRYYDDKGEVVYKSNPAVKEAWDLAAEFASEGLTAKLQQFTPGWDQGFS
                     NGTFATVSCPAWMLGYIQDKGGEKGADKWDVAQAPKPSNWGGSFLTVPSAGKNKEEAAK
                     LAAWLTAPKQQAKLFAERGSFPSAQAAYDLPEIADAKHEYFDDAPIGKIFAQAAEGAPV
                     QILGPKDLVIAQNLADVGMLQVDQKGKSSEEGWKAAVKAIDNALDQ"
     misc_feature    complement(3349..3363)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    3350..3364
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    3433..3450
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            3509..4564
                     /locus_tag="FRZ02_RS26875"
                     /old_locus_tag="FRZ02_26875"
     CDS             3509..4564
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638131.1"
                     /locus_tag="FRZ02_RS26875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26875"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_018468239.1"
                     /transl_table=11
                     /translation="MTAGRSNGRSGGRPTLEEVAARAGVGRGTVSRVINGSPRVSEATR
                     AAVEAAVAELGYVPNTAARALAANRTDAIALVVPEPETRFFTEPYFSDILSGIGAALGP
                     TDLQLLLTFADGARERRRLAQYLAAHRVDGVLLVSVHADDPLPDLLSQLEIPAVISGRR
                     SEDEPLASVDTDNYSGARAAVTHLLERGRTTIATISGRLDVYGAQRRLDGYRSALGDAG
                     RPPEDSLVAAGDFTEEGGRQAMRLLLDRHPELDAVFACSDVMAAGALQVLREAGRRIPE
                     DVALVGFDDSAVARLMDPPLTSVRQPTAAMGRAMTEALLAEIAEGRPDSSRLRRPRQVV
                     LKTELVVRASS"
     gene            4653..4880
                     /locus_tag="FRZ02_RS26880"
                     /old_locus_tag="FRZ02_26880"
     CDS             4653..4880
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948199.1"
                     /locus_tag="FRZ02_RS26880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26880"
                     /product="hypothetical protein"
                     /protein_id="WP_003948199.1"
                     /transl_table=11
                     /translation="MELPDYLIRLQRAADDEGRRLEHLDEDERDAARRLYFNAAAEVDV
                     AVRDFAATAGLDRHTVEKELRQQARQPPTE"
     gene            4921..5091
                     /locus_tag="FRZ02_RS33140"
     CDS             4921..5091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468238.1"
                     /locus_tag="FRZ02_RS33140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_015507854.1"
                     /transl_table=11
                     /translation="MNTRTDTAPRPAAVVNAEIRALLMRRGGLTPAERAAYERLLVEWA
                     QAVRAEVVVAA"
     gene            5351..5608
                     /locus_tag="FRZ02_RS26885"
                     /old_locus_tag="FRZ02_26885"
     CDS             5351..5608
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRZ02_RS26885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FRZ02_26885"
                     /product="hypothetical protein"
                     /protein_id="WP_067412198.1"
                     /transl_table=11
                     /translation="MEHRETPDGQWRTADLVVANDYEPLRGADAARDLAPGATRVVEYR
                     FSAAEEAPSGAQPLMIQAVRTDERRSGGLAGLRRSVLPTD"
     gene            complement(5852..6502)
                     /locus_tag="FRZ02_RS26890"
                     /old_locus_tag="FRZ02_26890"
     CDS             complement(5852..6502)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948197.1"
                     /locus_tag="FRZ02_RS26890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26890"
                     /product="hypothetical protein"
                     /protein_id="WP_003948197.1"
                     /transl_table=11
                     /translation="MSASQSAVAATLLDRHGSTYAREAGITLKDTPQPLYQLLVLSSLL
                     SARIRASVAVAAARALFHDGMRNPRTMADASWQERVDALGEGGYRRYDERTATQLGDGA
                     ELLLDAHRGDLRQLREEADGDEQTLVQGLRETPGMGPAGAGIFLREAQAVWPEYAPRFD
                     GKARQGAERLGLPQDPKRLARLAGDAGPAVLAAALVRAALEKKVAADVLEHAG"
     tRNA            complement(6656..6728)
                     /anticodon=(pos:complement(566855..566857),aa:His,seq:gtg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FRZ02_RS26895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FRZ02_26895"
                     /product="tRNA-His"
     gene            complement(6656..6728)
                     /locus_tag="FRZ02_RS26895"
                     /old_locus_tag="FRZ02_26895"
     misc_feature    6756..6767
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    6757..6775
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            complement(6820..7422)
                     /gene="orn"
                     /locus_tag="FRZ02_RS26900"
                     /old_locus_tag="FRZ02_26900"
     CDS             complement(6820..7422)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0000175 - 3'-5'-RNA exonuclease activity
                     [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="orn"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948196.1"
                     /locus_tag="FRZ02_RS26900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26900"
                     /product="oligoribonuclease"
                     /protein_id="WP_003948196.1"
                     /transl_table=11
                     /translation="MNDRMVWIDCEMTGLSLADDALIEVAALVTDSELNVLGDGVDIVI
                     RPPDEALETMPEVVRKMHTSSGLLAELAEGTTLADAEAQVLAYVREHVKEPGKAPLCGN
                     SVGTDRNFLARDMAALEGYLHYRIVDVSSVKELARRWYPRAYFNSPDKNGNHRALADIR
                     ESIAELRYYREAIFVPQPGPDSDTAKAIAAQHVLTSE"
     gene            complement(7528..8748)
                     /locus_tag="FRZ02_RS26905"
                     /old_locus_tag="FRZ02_26905"
     CDS             complement(7528..8748)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948195.1"
                     /locus_tag="FRZ02_RS26905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26905"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_003948195.1"
                     /transl_table=11
                     /translation="MSHDSTVTADLAGRKLSGRRRKEIVAVLLFSGGPIFESSIPLSVF
                     GIDRQDAGVPRYRLLVCAGEDGPLRTTGGLELTAPQGLEALARAGTVVVPAWRSITSPP
                     PAAALDALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVD
                     PRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGSEAAGALARRLVVPPRRAGGQERYLD
                     RSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWL
                     ITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARRPQ
                     QEQQRPEPVQPTQPVQVFDGPLPPQLRRTPQGVGAHHGDPGRGAPEAYLQGRAALPGQR
                     ERPLGGV"
     misc_feature    complement(8074..8076)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8945..8958)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    9012..9030
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.75"
                     /tool="antismash"
     misc_feature    9013..9029
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     misc_feature    complement(9097..9111)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.1"
                     /tool="antismash"
     gene            complement(9197..9610)
                     /locus_tag="FRZ02_RS33610"
     CDS             complement(9197..9610)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890128.1"
                     /locus_tag="FRZ02_RS33610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_261399635.1"
                     /transl_table=11
                     /translation="MPVPHVSGPDPAALLPGAAPARAPERGARAPGTACAGARAPRGLP
                     GARTAPRAACAPAASTAARSAGPAPVSTAVRWAAFGCVLAPVVLVVYGASAGGVMWVAP
                     VLAAVTGICRLLLRRAERGGATGARSAAGDVPR"
     misc_feature    9725..9739
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     gene            10136..10660
                     /locus_tag="FRZ02_RS26915"
                     /old_locus_tag="FRZ02_26915"
     CDS             10136..10660
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325548.1"
                     /locus_tag="FRZ02_RS26915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26915"
                     /product="universal stress protein"
                     /protein_id="WP_003948193.1"
                     /transl_table=11
                     /translation="MAGHESFESADRKRQVADPSAQPLAAEETRQPCDPAFRHGVVVGF
                     DGSTSSERALAYAIGMARRSGSGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLGL
                     ELACAEYLGDVPWILVERGGDICHELEEVGTEYEADAIVVGSSQGVVGRLFGSVAGRLA
                     RRARRPVVVIP"
     gene            complement(10692..12521)
                     /gene="glmS"
                     /locus_tag="FRZ02_RS26920"
                     /old_locus_tag="FRZ02_26920"
     CDS             complement(10692..12521)
                     /EC_number="2.6.1.16"
                     /GO_function="GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA]"
                     /GO_process="GO:1901137 - carbohydrate derivative
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="glmS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980526.1"
                     /locus_tag="FRZ02_RS26920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26920"
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="WP_003948192.1"
                     /sec_met_domain="GATase_7 (E-value: 2e-14, bitscore: 48.7,
                     seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIVGYIGRRDDVAPLLLEGLQRLEYRGYDSAGIAIHGKSGSKS
                     TGLKSVKAKGRVRDLEARVPARFKGSVGIAHTRWATHGAPNDENAHPHLDADSKVAVVH
                     NGIFDNASDLRARLTADGVVFLSETDTEVLAHLIGRSEADTLEGKVREAVGQIEGTYGV
                     AVLHADFPDRIVVARNGSPVVLGIGEKEMFVASDVAALVSHTRQVVTLDDGEMATLKAD
                     DFRTYTTEGSRTSATPTTVEYEAESWDMGGHDTYMHKEIFEQAEAVDRVLRGRIDDRFS
                     TVHLGGLNLDAREARGVRRIKILGCGTSYHAGQIGAQLIEELARIPADAEPASEFRYRN
                     PVVDPDTLYIAVSQSGETYDVLAAVQELKRKGARVLGVVNVVGSAIAREADGGLYVHAG
                     PEVCVVSTKCFTNTVVAFGLLALHLGRTRDLSVADGKRIIAGLRKLPEQIADILSREDE
                     IEKLAEEFTEARSMLFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEP
                     AMPTVAIVPDDDLLEKNRAALEEIKAREGKILAVAHREQEKADHTIVVPKNEDELDPIL
                     MGIPLQLLAYHTALKLGRDIDKPRNLAKSVTVE"
     misc_feature    complement(12551..12565)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            complement(12612..12887)
                     /locus_tag="FRZ02_RS26925"
                     /old_locus_tag="FRZ02_26925"
     CDS             complement(12612..12887)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608703.1"
                     /locus_tag="FRZ02_RS26925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26925"
                     /product="hypothetical protein"
                     /protein_id="WP_003948191.1"
                     /transl_table=11
                     /translation="MLERRTNHDDLVDHLVRTTPLSRGEAGRVVMDVLAYFDETTEECV
                     RRRHRELQAQGLGNTEIFERIAEELPRRAVAPPALSLRQLRRIVYG"
     misc_feature    complement(12838..12853)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.91"
                     /tool="antismash"
     misc_feature    complement(12850..12865)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.36"
                     /tool="antismash"
     gene            complement(13006..13914)
                     /locus_tag="FRZ02_RS26930"
                     /old_locus_tag="FRZ02_26930"
     CDS             complement(13006..13914)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638121.1"
                     /locus_tag="FRZ02_RS26930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26930"
                     /product="DUF4429 domain-containing protein"
                     /protein_id="WP_031178096.1"
                     /transl_table=11
                     /translation="MAEITQRDGSWSYEDGRIRIVPGAKAHPVRQVLGEVAVPLAAVAG
                     ITFERDRKGGRLRLRLRDGACPVVRAAEGRLPEGADPYRLVVEAGREDLAEYLVAEVRQ
                     ALLLEQIPEGPVERFLLPGPALPVSGGGGDGTAAFDGREVRLTWNWKGKETKTSAGPTT
                     LALADLTGVAWVPPQGLENGHLRFLTRSGGGKTVAPEHDPHALDLWGLSKKEHTAVLVA
                     AAVLVALAARGEPERSPGALDKAEAPAQLPLPPAPAPQAASADDPDALLRRLRELGELH
                     RDGVLTDEEFSLAKQAVLRRL"
     misc_feature    13891..13904
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.65"
                     /tool="antismash"
     gene            complement(14001..15821)
                     /locus_tag="FRZ02_RS26935"
                     /old_locus_tag="FRZ02_26935"
     CDS             complement(14001..15821)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407742.1"
                     /locus_tag="FRZ02_RS26935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26935"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_146583069.1"
                     /sec_met_domain="IucA_IucC (E-value: 6.1e-79, bitscore:
                     260.1, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTTPTDQLAAPPAHLTPELWAAAGRHLVRKGLAEFSHERLLKP
                     EPLPGAEPDAEGRTAHRVVTDDGVTEYRFAAKLLSLDHWDIAADSITRHGEGGTELPLD
                     ALDFILDTRTALGIGDAILPVYLEEISSTLSGAAWKLAQARPSAAELARAGFQAIETGM
                     TEGHPCFVANNGRIGFDVREYHQYAPETASPVRLLWLAARRDRSTFTSGAGLDYDTLVK
                     GELDPATLARFAATLAGQGLDLADYHLLPVHPWQWWNKLSVSFAAEVAQQRLVLLGEGD
                     DAYLAQQSIRTFFNTSHPDKHYVKTAMSVLNMGFMRGLSAAYMEATPAINDWLAQLIAG
                     DEVFRAARFSIIRERAAIGYHHRQYERATDRYSPYRKMLAALWRESPVPQLGEGQRLAT
                     MASLLHTDADGASLAGALIAESGLAPEVWLRRYLDAYLVPVLHSFYQYDLVYMPHGENV
                     ILVIEDGAVDRVIFKDIAEEICVMDPDAVLPPAVERIKAEVPEEMKILSIFTDVFDCYL
                     RFLNATLAGEGVLDEDTFWRTAAESVRAYQESMPQLADKFAQYDMFAPSFALSCLNRLQ
                     LRNNQQMVDLADPSGALQLVGDLVNPLAGR"
     gene            complement(15818..16423)
                     /locus_tag="FRZ02_RS26940"
                     /old_locus_tag="FRZ02_26940"
     CDS             complement(15818..16423)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203: putative siderophore biosynthesis protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407740.1"
                     /locus_tag="FRZ02_RS26940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26940"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_018468232.1"
                     /transl_table=11
                     /translation="MTTPRTAKVRPDRLAIRPLDLDADAGLVHGWVTHPKSAFWLMQGL
                     SVDEVRGEYASIADHPHHDAFIGLYEDSPAFLMERYDPAHVELVGLYDPEPGDVGMHFL
                     CAPTDTPLHGFTRAVIFAVMEYLFADPDTVRVVVEPDVRNAAVHALNEAVGFEIVEKIA
                     KPEKEAYLSVCTRDAFEAAKKAAATVPAGDDTKEQASR"
     gene            complement(16420..17730)
                     /locus_tag="FRZ02_RS26945"
                     /old_locus_tag="FRZ02_26945"
     CDS             complement(16420..17730)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080: lysine/ornithine N-monooxygenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948187.1"
                     /locus_tag="FRZ02_RS26945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26945"
                     /product="lysine N(6)-hydroxylase/L-ornithine
                     N(5)-oxygenase family protein"
                     /protein_id="WP_003948187.1"
                     /transl_table=11
                     /translation="MSTPLERSSRTASDSAEPLDLLGIGLGPFNLGLACLAEPLDEIDA
                     LFLETKPDFDWHSGMFLDGAHLQTPFMSDLVTLADPTSPYSFLNYLKESGRLYSFYIRE
                     NFYPLRTEYNDYCRWAAARLGSVRFSTTVTEVTYDEESALYTVTTDQGDTYRARHLALG
                     TGTPPHIPEPCQGLGGDLLHNSRYLEHKAALQAKKSITLVGSGQSAAEIYYDLLAEIDV
                     HGYQLNWVTRSPRFFPLEYTKLTLEMTSPEYIDYFHALPEDTRYGLEQKQKNLFKGIDG
                     ELINAIFDLLYEKNVRGPVPTRLLTNTALKTAARDESEGTYTLGLRQEEQGKDFELTSE
                     GLVLATGYQYRVPDFLEPVRDRIRWDGRGRFDIARNYSIDTTGRGIFVQNAGVHTHALT
                     SPDLGMGAYRNSVILRELLGTAPYAVEKSIAFQEFSV"
     gene            complement(17714..19171)
                     /locus_tag="FRZ02_RS26950"
                     /old_locus_tag="FRZ02_26950"
     CDS             complement(17714..19171)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894987.1"
                     /locus_tag="FRZ02_RS26950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26950"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_010638113.1"
                     /transl_table=11
                     /translation="MSLLAPRSHLLNDLNVEAYRRSVTEGVERVAASLTGATSPFTGVT
                     PAALAPVVDAVDLDRPLGDTTAALDELTDVYLRDAVYFHHPRYLAHLNCPVVIPAVLGE
                     AVLSAVNSSLDTWDQSAGGTLIERRLIDWTTGRIGLGEGADGVFTSGGSQSNLQAMLLA
                     REEAKAAHPTQLRVFTSDVSHFSVRKSATLLGLGPDAVVTIPTDRERRMRIEVLAAELR
                     RCEAEGLVPMAVVGTAGTTDFGSIDPLPEIAELCAQHNTWMHVDAAYGCGLLVSPTRRA
                     LLNGIEHADSVTVDYHKSFFQPVSSSALLVRDGATLRHATYHADYLNPRRAAEERIPNQ
                     VDKSLQTTRRFDALKLWMTLRVMGADGIGQLFDEVCDLAGEGWKLLVADPRFDVVVEPS
                     LSTLVFRYLPGQPTDPAQIDRANLYARKALFASGDAVVAGTKVDGRHYLKFTLLNPETK
                     ASDIAAVLDLIAGHAEQYLGESLVHAS"
     misc_feature    complement(19238..19256)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 36.53"
                     /tool="antismash"
     gene            complement(19505..20371)
                     /locus_tag="FRZ02_RS26955"
                     /old_locus_tag="FRZ02_26955"
     CDS             complement(19505..20371)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468230.1"
                     /locus_tag="FRZ02_RS26955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26955"
                     /product="siderophore-interacting protein"
                     /protein_id="WP_146583071.1"
                     /transl_table=11
                     /translation="MTTTPTAPARTPFRFFDVEVRGSRRLSPSLVRLTFGGEELALFES
                     GGRDQSCSLFLPHPGQRVPRVPVEAGENWWAAYRAMPEQERAVMRSYTVRAQRRADDGT
                     TEFDVDFALHGDTGPACRWAARALPGDRVVVLGPAVTENVSVRFRPPASAAWALMWADL
                     TSLPATEAILEWLPAGFPVRLWIEVPHAADRRELATAADAEITWLVTDEGAPSAAEAVR
                     AAELPAGEPYAWIAGEAGRMRTLRRHLVGERGFDRRAVTFVGYWREGASEEQLRAESLA
                     TGKRRTA"
     misc_feature    complement(20405..20423)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 30.62"
                     /tool="antismash"
     gene            20694..21347
                     /locus_tag="FRZ02_RS26960"
                     /old_locus_tag="FRZ02_26960"
     CDS             20694..21347
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468229.1"
                     /locus_tag="FRZ02_RS26960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26960"
                     /product="hypothetical protein"
                     /protein_id="WP_146583073.1"
                     /transl_table=11
                     /translation="MNRPPPPAMTALAVAAGLSLAACGGGGTGEEGEKPIAGAGQEGGG
                     KSASPTASPEAGPDRPKIDLPADLTMTFEGGKSGDAVKDAVLADSAERMRAVNAVIAGT
                     APENVLGHYNTGKALEAAASWVGEFEKAGATVTGEVRYYDREVTLDGKKAATLSFCADE
                     SKGFSKDAETGKVSKTPVSKNSYVFYNSRLERNDAGTWQTTQIVSTRGAGQCQP"
     gene            21335..22378
                     /locus_tag="FRZ02_RS26965"
                     /old_locus_tag="FRZ02_26965"
     CDS             21335..22378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407731.1"
                     /locus_tag="FRZ02_RS26965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26965"
                     /product="hypothetical protein"
                     /protein_id="WP_010638108.1"
                     /transl_table=11
                     /translation="MPAIGRKTRGVALGAALFLLAGAAPAWADIVPGGGNGSGSEGEVG
                     GGSGDDGTINASAGAVVYDRSKNGSGQSAGPVTSASDWTPPACYYAPAFTPDQLKAELE
                     PIWEAGSTGPEWDAEQRDRYVNGKPYKDFNKEKEGEGYWWDGFVADGRIGDPGALDCQG
                     PNFWVDTGDAPPADVPEAITPEMLAQLAYAELRVPSTEVKLAPEVETKVNLPTWAWLDG
                     ATFKPVSVTASVPLLGMTATTTAEPVSLRIEPGTADARLHPASGECALVDGSIGERYAK
                     GKADRTPPCGVTYLRSSGDGTFPLQATLTWKISWTGTGVNDEQPLPDGSFGAEQPVTVR
                     EIQAVNR"
     gene            complement(22388..23014)
                     /locus_tag="FRZ02_RS26970"
                     /old_locus_tag="FRZ02_26970"
     CDS             complement(22388..23014)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407728.1"
                     /locus_tag="FRZ02_RS26970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26970"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_015507855.1"
                     /transl_table=11
                     /translation="MTAEKDGRRVGRPPLTERRKAATRLEIAREAVRLFAAQGVAATTA
                     DEIAAAAGISPRTLWRYCSSKEECVGPLLTTALDAAAERLASWPRERTLTDGISTHPPG
                     RSAAALAEDEQALRDLVRLVRTEPGLRAVWLQVHHAAEPVLARVLAARTGRSPDALEPR
                     VQAALLNTALRVAVEEWAWHTAPGTGTPGEAITEVLAIAEAGLPR"
     gene            23169..23936
                     /locus_tag="FRZ02_RS26975"
                     /old_locus_tag="FRZ02_26975"
     CDS             23169..23936
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (11-177). E-value: 4.9e-10.
                     Score: 31.5. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS26975_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948181.1"
                     /locus_tag="FRZ02_RS26975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26975"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_129863160.1"
                     /sec_met_domain="adh_short (E-value: 7.8e-36, bitscore:
                     118.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTTGLAGRAVVVTGAGSGIGRAAALRFAAEGAKVLLADLNGEA
                     AEAAAREITEAGGTAVTVAGDLSDQAVVDEVVATAVERFGSLDVLVNNAGIMDRMSAAG
                     DTEDAEWERVVRVNLTAPFLLTRAALPHLLATGKGAVVFTASEASLRGSAAGAAYTAAK
                     HGVAGLTKSVAVMYREKGLRANAIAPGGTATNIQVDADREAHGPAVLGSYLRNVGSPAQ
                     AEEQAAAIVFLASDAASNINGVILPVDGGWAAV"
     CDS_motif       23202..23279
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FRZ02_RS26975_0001"
                     /evalue="8.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="FRZ02_RS26975"
                     /protein_end="37"
                     /protein_start="11"
                     /score="12.0"
                     /tool="antismash"
                     /translation="VVVTGAGSGIGRAAALRFAAEGAKVL"
     aSDomain        23202..23699
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS26975_PKS_KR.1"
                     /evalue="4.90E-10"
                     /label="FRZ02_RS26975_PKS_KR.1"
                     /locus_tag="FRZ02_RS26975"
                     /protein_end="177"
                     /protein_start="11"
                     /score="31.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVTGAGSGIGRAAALRFAAEGAKVLLADLNGEAAEAAAREITEA
                     GGTAVTVAGDLSDQAVVDEVVATAVERFGSLDVLVNNAGIMDRMSAAGDTEDAEWERVV
                     RVNLTAPFLLTRAALPHLLATGKGAVVFTASEASLRGSAAGAAYTAAKHGVAGLTKSVA
                     VMY"
     gene            24023..24445
                     /locus_tag="FRZ02_RS26980"
                     /old_locus_tag="FRZ02_26980"
     CDS             24023..24445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638101.1"
                     /locus_tag="FRZ02_RS26980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26980"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_146583075.1"
                     /transl_table=11
                     /translation="MNQDEEEIRRLIEEWASAVHRGDLAAVVRDHADDLVMYDVPPPYE
                     GLRGLDAYRAVWPGFFAWQASGAEFTLDTLDVTAGRDVAYAHALLRCGTPEELAERPAL
                     RLRLTLGLRKEDGRWVVAHEHHSFPDLSSEPGPSSS"
     gene            complement(24397..24657)
                     /locus_tag="FRZ02_RS26985"
                     /old_locus_tag="FRZ02_26985"
     CDS             complement(24397..24657)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638100.1"
                     /locus_tag="FRZ02_RS26985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26985"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_059214216.1"
                     /transl_table=11
                     /translation="MPPEDDGHAIQVHLDRLLAARSMTLAELAARVGVTNVNLSVLKNG
                     RAKAIRFTTLTAICRVLECQPGDLLSYDEEGPGSEERSGNE"
     gene            complement(24657..25277)
                     /locus_tag="FRZ02_RS26990"
                     /old_locus_tag="FRZ02_26990"
     CDS             complement(24657..25277)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894981.1"
                     /locus_tag="FRZ02_RS26990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26990"
                     /product="hypothetical protein"
                     /protein_id="WP_129863161.1"
                     /transl_table=11
                     /translation="MSEDRKMLEPLTSVVSVTLRILLGALVAGFLLSLFVDGVHWGRGD
                     LCVTVDWASTSGGDFHPFEPLPGAEVGYTPRFCAEEPTTWQQVLGVLRTAPLTVMLVGG
                     LYLLDRLLRLAVREGVHTRGTAARLRVLGWWLLLGSLVVETAASVAGGLLLGTLTDDEV
                     ADAAWAQLWSAPYLAVLTGLGLLTFARIVGASALLRDELDAVV"
     misc_feature    complement(25294..25309)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    25295..25309
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    25298..25311
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.33"
                     /tool="antismash"
     misc_feature    25298..25314
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.08"
                     /tool="antismash"
     misc_feature    complement(25301..25314)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.57"
                     /tool="antismash"
     misc_feature    complement(25304..25318)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    25314..25330
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.33"
                     /tool="antismash"
     gene            complement(25588..26217)
                     /locus_tag="FRZ02_RS26995"
                     /old_locus_tag="FRZ02_26995"
     CDS             complement(25588..26217)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468224.1"
                     /locus_tag="FRZ02_RS26995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_26995"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_391595640.1"
                     /transl_table=11
                     /translation="MCGVTQADAPTRQRLLAAAKQLFLEKGADQVSLRAVNAAAGLNPG
                     AVHYHFGSREGLVSALLEQELGPVWNSRWAAVSESRATGVQEVRRLVEGLVEPFADLVA
                     TRDGRVLCHLLARAALPSGQLPNVPTAFTPAPFEVRVGRALPDLSPQEVSERCALAFTL
                     VMETYGRPTAKGVAENASFPATATVTAFVLAGLTAPPVPEKPGGSA"
     gene            26343..>27133
                     /locus_tag="FRZ02_RS27000"
                     /old_locus_tag="FRZ02_27000"
     CDS             26343..>27133
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468223.1"
                     /locus_tag="FRZ02_RS27000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_27000"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_146583077.1"
                     /transl_table=11
                     /translation="MGTYAVTGSASGMGAASAARLREAGHRVVGVDLRDADVTADLGTA
                     DGRRHAADEILRLCGGALDGVAAVAGVGPNLPDAAAVASINYFGPVALLDALRPALERE
                     GGGRAVVIGSNSATTVPMIDDHLVGLLLAGDEEAARAHAAGAQRSLPAALAATSPSISA
                     YATSKFALARWVRRTAVTPEWARRGITLNTIAPGAVVTPLMTDSTLSEDDLDPDTFPTP
                     MPRGIFGRPADIAFWVAQFLSPEAGFTTGATLTVDGGTDAA"
ORIGIN
        1 agggtgccca gcagcgcgcc ggccatgatc accgactggt cggggatgta cccccggccc
       61 aggccggtga gggccacctg caccgtgggg ctgccgttct gggtcagcgc gatgatcggc
      121 cagaagaagt cgttccagga ctgcacgaag gtcagcatcc cgagcaccgc catcgcgggc
      181 cgggccgccg ggaagaccac gtgccacagg acccgcaggc tgttggcgcc gtcgacccgg
      241 gccgcctcga tgatctcggt gggcagcgcc tggagcaggt actgccgcat gaagaagaca
      301 ccgaaggcgg tgaccagggt cggcaggatg accgcctgga gctggtcgga ccaggagagc
      361 ttggccacca tcatgtacag cggcacgacg ctgagctggg gcggcaccat catcgtgccg
      421 atcaccagca gcagcagcgc gttcttgaac cggaaccgca gcttggcgaa ggcgaacccg
      481 gccagggtcg agaagagcac cgtgccgacg gagaccgtgc cggccaccac cagggtgttc
      541 agcagggccg accccatgtt ggcgtcggtc caggcgatct ccaggttctt gaagaggttc
      601 ccgccgaacc agaagggcgg cggggtctcg gccagccgcg tgttgttccg cgaggccgcg
      661 atggccgtcc agaccagcgg gaagagcgag atgaaggtga ccacgccgag cacggcgtac
      721 gtgatccggc cgccgtgcag ctggcgcccg gccccgctgc ggcgcggccg ccgggaccgc
      781 ttcccgggcg gcgtggcgag ggtgcgggga gcggagtcct cgcgggcggg cgatggtgcg
      841 atgctcatgc tttcccctcg cctcggcgca gccaccgggt gaccgcgaga gagaccagcc
      901 cgatcacgat cagcagcagg aacatggccc aggcgatggc ggacgcccgg cccaggtgca
      961 ggttggtcca gccctgctcg tacaggtaca ggccgagggt ctggaactgg tgctcggagc
     1021 cgcccgtcgc cccgccgccg ccgttgaaga gcagcggctc gccgaagagc tggatggcgc
     1081 cgatggtcga gacgaccacg gtgaacagga tggtcggccg cagcgagggc agcgtcacgt
     1141 gcaggaactg ctgccagcgc gaggcgccgt ccagggccgc cgactcgtac aggtcggcgg
     1201 ggatggactg catcgcggcc aggtagatca gcgcgttgta gcccgtccag cgccacacga
     1261 cgatggagga gacggccagt tgtgaggtga agctgccgtt ctgccagtcg atgtgctcga
     1321 aaccggccag cgacaggaac cagttgatca tcccgtagtc gcggccgaag agcatgacga
     1381 agaccagggt cgccgccgcc accgaggtgg cgtacggggt gagcgccgcc acccggaaga
     1441 acatcgagcc gcgcagccgg tagttgagca gatgggcgat gcccagggcc atcagcagct
     1501 gcggcaccgt ggagaggatg ccgatggtga aggtgttctg gagcgcgttc cagaagaact
     1561 cgtcgtcgag caggcgcgtg tagttgcgca gcccgatcca ctccatgtcg ttgggggccg
     1621 tcagctccac ccggtggagc gaggcccacc cggtgtagag cagcgggaag agaccgaagg
     1681 ccgcgaagaa gaggaagaac ggcgcgatga acgcgtacgg actccacttc acgtcccgcc
     1741 ggtaccagcg ggagcgccgc tcgcgccgcc ggtcggccgc ttccctgccg gggtcctggg
     1801 gcggccccga ggccaccgcc accccgctcg cgggggccgc cgcgccctcc tccaccgagg
     1861 agggcgcggc cgccgagaat tcactcgcca tcgtgggtca ctggtccagt gcgttgtcga
     1921 tcgccttgac cgcggccttc cagccctcct cggaggactt gcccttctgg tcgacctgga
     1981 gcatgcccac gtcggccagg ttctgcgcga tcaccaggtc cttcgggccg aggatctgca
     2041 ccggggcgcc ctcggcggcc tgggcgaaga tcttgccgat cggcgcgtcg tcgaagtact
     2101 cgtgcttggc gtcggcgatc tccggcaggt cgtaggcggc ctgcgcgctc gggaaggagc
     2161 cgcgctcggc gaagagcttc gcctgctgct tcggcgcggt cagccacgcc gcgagcttcg
     2221 ccgcctcctc cttgttcttg ccggccgagg ggaccgtcag gaaggagccg ccccagttgc
     2281 tgggcttcgg cgcctgggcg acgtcccact tgtcggcgcc cttctcaccg cccttgtcct
     2341 ggatgtagcc gagcatccac gccgggcagg agaccgtggc gaaggtgccg ttggagaagc
     2401 cctggtccca gccgggggtg aactgctgga gcttggcggt cagtccctcg gaggcgaact
     2461 cggccgccag gtcccaggct tccttcaccg ccgggttcga cttgtagacg acctcgccct
     2521 tgtcgtcgta gtagcgggtc tcgctgctgc cggtcaccgc ggccatcacg ccgggcgcgc
     2581 cgtcgacgaa cttggcgccc ttgggagcct tcttctggaa ctccttgccg gcttccaggt
     2641 acttgtccca gtcgcccgcc cacaacttgc cgacctcctc gcggtcggtc ggcaggcccg
     2701 ccttctcgaa gaggtccttg cggtagcaga tgccctgcgg accgatgtcc gtgccgagcc
     2761 ccaccgtctt gcccgcctcg gtggtgccct gcgcccactt ccactccagg aaggcggcct
     2821 tgtcggcgcc gggggccttg gagaggtcct ccagcttgtc gccctgggtc tggacgatct
     2881 ccgcgatgtt gttggcctcg acggcctgga tgtcggcgag accgctgccg gtgcccaggt
     2941 gggtgaggag ctgcgggtag tagttctcgt tccgctcgat ggacgtctgc ttgatgacga
     3001 cgtccttgtt ctccttcatg tactggtcgt agagtccggc ctccttgagg ccgaacgcac
     3061 cgaagacccc gacggtcagc gtggtcttcc cctggtccga accggcatcg cccccggcgg
     3121 cctcgggctc gtcgtccgac gcgcagcccg cgagcaggct ggtccccagg gcggcgacgg
     3181 ccgccaggac caccgccttg cgggccgtac ggcttctcgt acgcatggtg cgcatggtct
     3241 cctcctgacg ccggtccggt cccggcccgt caaccccctt gcgggcggct gaagtcggct
     3301 cctccgggtc gaaccaggga atgtacgggt gttggagtgg cagctagggt gggagcgctc
     3361 ccacccgtga tgtcgtgaag agtcgcggct gcgggcagga gtgtcaagac acatgacgcc
     3421 gccaggtccg gtcggttatc gggctgttac ggtctcctcc gatcctgggg cacgacacgg
     3481 gcgcgtgccc actactggga ggcaacggat gacggctggt cggagcaacg ggcgcagcgg
     3541 gggccgcccc accctcgaag aggtcgccgc ccgcgccggg gtcggccgcg gcacggtctc
     3601 ccgcgtcatc aacggctccc cccgcgtcag cgaggccacc cgcgccgccg tcgaggccgc
     3661 cgtcgcggaa ctgggttacg tcccgaacac cgccgcccgc gccctggccg ccaaccgcac
     3721 cgacgccatc gccctggtcg tccccgaacc cgagacccgc ttcttcaccg agccgtactt
     3781 ctccgacatc ctcagcggca tcggcgccgc cctcggcccg accgacctcc agctcctcct
     3841 caccttcgcc gacggcgccc gcgaacgccg ccgcctcgcc cagtacctcg ccgcccaccg
     3901 cgtcgacggc gtcctcctgg tctccgtcca cgccgacgac ccgctgcccg acctcctctc
     3961 ccagctggag atccccgccg tcatcagcgg ccgccgcagc gaggacgagc cgctggcctc
     4021 cgtcgacacc gacaactact ccggcgcccg cgccgccgtc acccacctgc tggaacgggg
     4081 ccgcaccacc atcgccacca tcagcggccg cctcgacgtc tacggcgccc agcgccgcct
     4141 cgacggctac cgctccgccc tcggcgacgc cggccggccc cccgaggaca gcctggtcgc
     4201 cgccggtgac ttcaccgagg agggcggccg ccaggccatg cgcctcctcc tcgaccgcca
     4261 cccggaactc gacgccgtct tcgcctgctc cgacgtgatg gccgccggcg ccctccaggt
     4321 actgcgcgag gccggccgcc gcatccccga ggacgtcgcc ctggtcggct tcgacgactc
     4381 cgccgtcgcc cgcctgatgg accctccgct cacctccgtc cgccagccca ccgccgccat
     4441 gggccgcgcc atgaccgagg cgctcctcgc cgagatcgcc gagggccgcc ccgacagctc
     4501 ccggctgcgc agaccccggc aggtcgtcct gaagacggag ttggtggtgc gggcctcgtc
     4561 ctgagccggt cgcggcatcg gcgcggggtg cgccgggggc gcgcggccga gcctcccgcc
     4621 cccggccggc cccgcgccgt accatccctc gggtggaact ccccgactac ctgatcaggc
     4681 tccagcgcgc ggccgacgac gaggggcgcc ggctcgaaca cctcgacgag gacgagcggg
     4741 acgcggcgcg gcgcctctac ttcaacgccg cggccgaggt cgacgtggcc gtacgcgact
     4801 tcgccgccac cgccggactc gaccgccaca ccgtggagaa ggaactgcgc cagcaggccc
     4861 gccagccccc cacggagtga gcgcggcccg ttgtcgtacc ccccaagtac ggtcggctcc
     4921 atgaacaccc gtacggacac cgcgccccgc cccgccgccg tggtcaacgc cgagatccgc
     4981 gccctcctca tgcgccgcgg cggcctgacc cccgccgagc gcgcggcgta cgagcggctg
     5041 ctcgtcgagt gggcccaggc ggtccgcgcc gaggtggtcg tcgcggcctg acccgtccac
     5101 aaccgccacg ccctcttcct cttcatgatc gacaacggtc aggcgagcga gaggcccccc
     5161 gtgaacaggc agaagagcag gcggggagcc gccccggcag cccgaggacg gcgtccccct
     5221 gcgccccgga ggcgcccccg ccaccgtcct cgtcaagctc tgcaacacca cggaccggcc
     5281 gctgaccggc atcgccctct ccgcccagct ggagtggacc gacgcgggcg agcgcgaccc
     5341 ccggctggag gtggagcacc gggagacccc ggacggccag tggcgcaccg ccgacctggt
     5401 cgtcgccaac gactacgagc cgctcagggg cgccgacgcc gcccgcgacc tggccccggg
     5461 agcgacccgg gtcgtcgagt accggttcag cgccgccgag gaagccccct ccggcgctca
     5521 gccgctgatg atccaggccg tccggaccga cgagcggcgc agcggcggtc tggccggact
     5581 gcggcggagc gtgctgccca cggactgacg cccggtcacc ggagcgcggc ccgtacgttc
     5641 accacccacg gccagtttcg tcacccgtcg ccgccatgtg cacgacccgc tccgcccgtg
     5701 cccgtcacgc ggccccgcgc acccgctccg cgcccgctgc gggatcagcc tgcgggccac
     5761 ggcgctcgcc cccgacccgg cgctcctgag cgtccgcgcc gacccccggc ggcagctatg
     5821 gcgccgtacg gcctcagagg cggggcgcgg ctcagcccgc gtgttccagg acgtcggcgg
     5881 cgaccttctt ctccagggcg gcccggacga gtgcggcggc gaggacggcc gggcccgcgt
     5941 ccccggcgag gcgggccagg cgcttcgggt cctgggggag gccgagccgc tcggcgccct
     6001 ggcgggcctt gccgtcgaag cggggcgcgt actcgggcca gacggcctgg gcctcgcgca
     6061 ggaagatgcc ggcgcccgcg gggcccatgc ccggggtctc ccgcaggccc tggacgaggg
     6121 tctgctcgtc gccgtcggcc tcctcgcgga gctgccgcag gtccccccgg tgtgcgtcga
     6181 ggagcagttc ggcaccgtcg ccgagctggg tcgcggtccg ctcgtcgtac cgccggtaac
     6241 cgccttcgcc gagggcgtcc acccgctcct gccagctcgc gtccgccatg gtgcgcggat
     6301 tgcgcatccc gtcgtggaac agggcgcggg cggcggccac cgcgacggag gcccggatgc
     6361 gggcgctgag cagggaactg aggacgagca actggtagag cggctgcggg gtgtccttga
     6421 gggtgatccc cgcctcccgc gcgtaggtgc tgccgtgccg gtcgaggagg gtggcggcga
     6481 cggcggactg cgaagcactc acgtccggtc tcccttcgta cgaggcgtac gtgtccctgg
     6541 aggcgtgcct gcttcccact gtggcgcgga tcgggcgggg tcgcgcgggg agcggcccgc
     6601 gggggaacgc caagagcccc gtcctgatct ctcaggacgg ggctcttggc cacagggtga
     6661 gtgacgggac ttgaacccgc ggccacctgg accacaacca ggtgctctac caactgagct
     6721 acacccaccg cgtccggtcg tttccgaccg gccgagaaaa agtgtacagg gtccgagggg
     6781 gtgctcgcgc acaccttttc ccgggggccg cgcggggcct tattccgagg tcagcacgtg
     6841 ctgggcggcg atcgccttcg cggtgtcgga gtcgggcccc ggctgcggca cgaagatcgc
     6901 ctcgcggtag tagcgcagct cggcgatgga ctcgcggatg tcggcgaggg cgcggtggtt
     6961 gccgttcttg tcggggctgt tgaagtaggc ccgcgggtac caccggcgcg ccagctcctt
     7021 caccgaggag acgtccacga tgcggtagtg gaggtacccc tccagcgccg ccatgtcccg
     7081 cgcgaggaag ttccggtcgg tgccgaccga gttcccgcac agcggagcct tgccgggctc
     7141 cttgacgtgc tcacggacgt acgcgaggac ctgcgcctcc gcgtcggcca gcgtggtgcc
     7201 ctccgccagc tcggcgagga gcccggagga ggtgtgcatc ttgcgcacca cctcgggcat
     7261 ggtctccagc gcctcgtccg gcggacggat cacgatgtct acgccgtcgc cgagcacgtt
     7321 cagttccgag tcggtgacca gcgcggccac ctcgatgagt gcgtcgtccg ccagcgagag
     7381 cccggtcatc tcgcagtcga tccacaccat gcggtcgttc atacggctca gcctaggccc
     7441 tgtccgcgaa aacccgtccg gcccgtgcgg ggtccggcac acaccgcgaa gtgcgttccg
     7501 gaccccgagg gccggagctg tcctctctca gacgccgccc agcggacgtt cccgctggcc
     7561 cgggagtgcc gcgcgcccct ggaggtacgc ctccggtgct ccccggcccg ggtcgccgtg
     7621 gtgggcgccg actccctgcg gcgtccggcg cagctgcggc gggagcggcc cgtcgaagac
     7681 ctgcaccggc tgcgtgggct gcaccggctc gggccgctgc tgctcctgct gcggacggcg
     7741 ggcccggtag gcggcccggt acgcggcggg ggaggagccg agctggcggc ggaagtgccc
     7801 gcgcagcgcg accggcgacc ggaagccgca acggcccgcg acctcgtcca ccgagtagtc
     7861 ggaggtctcc aggagccgct gcgcctgcag cacgcgctgg gtgatgagcc actggagcgg
     7921 ggcgctgccg gtcagcgaac ggaagcgccg gtcgaaggtc cggcggctca tgtacgcgcg
     7981 tgcggccagc gtctccacgt cgaactgctc gtggaggtgc tccagcgccc aggcgacgac
     8041 ctcggccagc gggtcggcgc cgatctcctc cggtaaagac ctgtcgaggt agcgctcctg
     8101 cccgcccgcc cggcgcggcg gcacgaccag gcggcgcgcc agggcgcccg cggcctcgct
     8161 gccgtgatcg gtccggacga tgtgcaggca gagatcgatc ccggcggcgg tgcccgccga
     8221 ggtgagcacg tccccgtcgt cgacgaagag ctcccgcggg tcgacgtgga ccgaggggta
     8281 gcgcttggcc agcgtcggcg cgtacatcca gtgcgtggtg gccggcctgc cgtcgagcag
     8341 tccggcggcg gccaggacga acgcgccggt gcacagcccg acgatgcgcg cgccctcctc
     8401 gtgcgcccgg cgcagcgcgt ccagcgcggc ggcgggcggg ggtgaggtga tggaccgcca
     8461 ggcgggcacc accaccgtcc ctgcccgggc gagggcctcc aggccctgag gcgccgtcag
     8521 ttccagtccg ccggtggtcc gtagcggtcc gtcctcgccg gcgcagacca gcagccggta
     8581 gcgcggcacg cccgcgtcct ggcggtcgat gccgaagacg gagagcggga tggaactctc
     8641 gaagatggga ccgccgctga agaggagaac cgcgacgatc tccttgcggc gccgcccgga
     8701 gagtttgcgg cccgcgaggt ccgccgtgac ggtggagtcg tggctcatgt gactaagccc
     8761 ccctcggtgg ccgtgacact ccagtcctgt cggatctgtc gctcctgcac gtttcccctc
     8821 ggtcctgcgc gtgtcccccg ccataagaca gtcatgatcg aatctactgt gtcccgtggt
     8881 gccaccgtga ccagttgagc agacgccgga atgtcgacaa ggcaacgtgg cgtgaagcat
     8941 tcgatcacga agcgtcgcac tccagggctc gactgggaag tgcgtctgcg gcgggtggcc
     9001 ggtccccgta gggtgcgaac gcctcgcacg gtcctgtcct cgcaggtcgt gccgggggtg
     9061 acgggggttc acccaccctg gtgcaacggt tcgtcaactt ggctgaaaac atacgggcgc
     9121 gtgcgtgcga accggtcagc tctccggtgt acgaaaagtg cgccccctga ccgccccccg
     9181 tgcgcccctc tcgcccctac ctgggaacgt ctcccgcggc gctccgggcg cccgtcgcgc
     9241 cgccccgctc cgcccggcgc aacaacagcc ggcagatccc ggtcaccgcg gccagtaccg
     9301 gtgccaccca catcacgccg cccgccgacg ccccgtagac caccaggacc accggggcga
     9361 ggacgcagcc gaaggcggcc cagcggacgg cggtgctcac cggggccggt ccggcactcc
     9421 gtgccgccgt ggaggccgcg ggcgcgcagg ccgcgcgggg tgcggtgcgg gccccgggga
     9481 ggccgcgtgg ggccctggcg cccgcgcagg cggttcccgg tgcccgcgcg ccgcgttccg
     9541 gcgcccgtgc gggcgcggcg ccggggagga gggcggcggg gtccgggccg gagacgtggg
     9601 ggacgggcac gaggggctcc cagggtgggc gggtacgccg gttcaacgcg ccgcccgcgc
     9661 ccgggtcact gcggggcggc gcgggctggg ccgacccggg gaccccgtgt cccccgggcg
     9721 gcgggggccg tccggccgtt gcgatcgggg cgccgctcgg gcatgctccg tccagcgcgc
     9781 cgcccggcgg tggcgtccgg aggggcctca ccgggccggt tcgggtccct ccgggagctt
     9841 tcgccgggcg gtgcgcgccg gtccgtgaga acggcgcatg ggcgggccct cttctgggta
     9901 cgggccgggc aaggtccgaa cgcgggagaa gtggcgccgt acccttgggg cgagtggttg
     9961 ggaagatgct tcccggacac agcgggccgg tccctcgggc cggtcgtcgc ccctccgggc
    10021 gccgtcggca ccgccgctcg acctccggac ccggggttcc ccccggagcc gtgctcactc
    10081 cgtcagccgt ccccttccca cgagtccccc aaggacctct cccgccgaga caccgatggc
    10141 cggtcacgaa tcctttgaat cagcggaccg caagcggcag gtggccgatc cctcggccca
    10201 gcccctggcg gcggaagaaa cacgtcagcc ctgcgacccg gccttccggc acggcgtcgt
    10261 cgtcggcttc gacggctcga cctccagcga gcgcgccctc gcctacgcga tcggcatggc
    10321 ccgccgctcg ggctcgggcc tgatcatcgt ccacgtggcc aaccggctgc ccaccacggt
    10381 gtgggccggc tgcgagccgc ccgtcttcgt cgacgttccc gaccaccgca ccgaggtgct
    10441 gggactggag ctggcctgcg ccgagtacct cggcgacgtg ccctggatcc tcgtcgagcg
    10501 cggcggcgac atctgccacg agctggagga ggtcggcacc gagtacgagg ccgacgccat
    10561 cgtggtcggc tccagccagg gcgtcgtggg gcggctcttc ggctcggtcg ccgggcggct
    10621 ggcccggcgg gcgcgcagac cggtggtcgt catcccctga gccggggcgg cccaggggac
    10681 gaccggaccg gctactcgac ggtgacggac ttcgccaggt tgcgcggctt gtcgatgtcg
    10741 cggccgagct tcagcgcggt gtggtaagcc agcagctgga gcgggatgcc catgaggatc
    10801 gggtccagct cgtcctcgtt cttcggcacc acgatggtgt ggtcggcctt ctcctgctcg
    10861 cggtgggcga cggcgaggat cttgccctcg cgggccttga tctcctccag cgccgcccgg
    10921 ttcttctcca gcaggtcgtc gtcggggacg atcgccacgg tcggcatggc cggctcgatc
    10981 agcgccagcg ggccgtgctt cagctcggag gccgggtacg cctcggcgtg gatgtacgag
    11041 acctccttga gcttcagcga ggcctcgcgg gccaccggat agccccgcac gcggccgatg
    11101 aagagcatcg agcgggcctc ggtgaactcc tcggccagct tctcgatctc gtcctcgcgg
    11161 gagaggatgt cggcgatctg ctcgggcagc ttgcgcaggc ccgcgatgat ccgcttgccg
    11221 tcggccaccg acaggtcgcg ggtgcggccc aggtgcagcg cgagcaggcc gaaggcgacc
    11281 acggtgttgg tgaagcactt ggtggagacc acgcacacct cgggcccggc gtgcacgtac
    11341 agcccgccgt cggcctcgcg ggcgatggcc gagccgacca cgttgaccac gccgaggacg
    11401 cgggcgccct tgcgcttcag ctcctgcacg gcggcgagca cgtcgtaggt ctcgccggac
    11461 tgggagacgg cgatgtagag cgtgtccggg tcgaccaccg ggttgcggta gcggaactcc
    11521 gaggccggct cggcgtcggc ggggatgcgg gcgagctcct cgatgagctg ggcgccgatc
    11581 tggccggcgt ggtacgaggt gccgcagccc aggatcttga tccggcggac cccgcgtgcc
    11641 tcacgggcgt cgaggttgag gccgccgagg tgcacggtgg agaaccggtc gtcgatccgg
    11701 ccgcgcagca cccggtcgac cgcctcggcc tgctcgaaga tctccttgtg catgtacgtg
    11761 tcgtggccgc ccatgtccca ggactcggcc tcgtactcca ccgtggtggg cgtggcggag
    11821 gtgcgcgagc cctcggtggt gtaggtgcgg aagtcgtcgg ccttgagggt ggccatctcg
    11881 ccgtcgtcca gggtgacgac ctggcgggtg tgggagacca gggcggcgac gtcggaggcg
    11941 acgaacatct ccttctcgcc gatgccgagg acgaccgggg agccgttgcg ggcgacgacg
    12001 atccggtccg ggaagtcggc gtgcagcacg gcgacgccgt aggtgccctc gatctggccg
    12061 acggcctcgc ggaccttgcc ctccagggtg tcggcctcgg agcggccgat gaggtgggcg
    12121 aggacctcgg tgtcggtctc ggagaggaag accacgccgt cggcggtgag ccgggcgcgc
    12181 aggtcggagg cgttgtcgaa gatgccgttg tggacgacgg cgaccttgga gtcggcgtcc
    12241 aggtgcgggt gggcgttctc gtcgttgggg gcgccgtggg tggcccagcg ggtgtgcgcg
    12301 atgccgacgc tgcccttgaa gcgggccggg accctggcct ccaggtcgcg gacgcgcccc
    12361 ttggccttga ccgacttcag cccggtcgac ttggagcccg acttgccgtg gatggcgatg
    12421 ccggccgagt cgtacccccg gtactccagg cgctggaggc cctccagcag cagcggcgcc
    12481 acgtcgtcgc gacggccgat gtatcccacg attccgcaca taggtgaaac ccctcctgga
    12541 cgtgttccgg cgggccggtg ggcccgcccg ggtgctcggc gctcccggca tgagggtgcc
    12601 gggcggcctg gtcagccgta gacgatgcgc cgcagctggc gcagggagag tgccgggggc
    12661 gccacggccc tgcgcggcag ctcctcggcg atccgctcga agatctccgt gttgcccagg
    12721 ccctgggcct ggagttcgcg gtgacggcgg cggacgcact cctcggtcgt ctcgtcgaag
    12781 tacgccagga cgtccatcac cacccggccg gcctcgccgc ggctcagcgg cgtggtgcgg
    12841 accaggtggt cgaccaggtc gtcatggttc gtacggcgtt cgagcacgga tcgatactgg
    12901 gtcgcgcgga cgggtttcgc aacattcctg cccgatatcg ggcacggacg agggagaagt
    12961 ggggcggaat gggggattcc agcgacttcg cgcgctccgg ccgccttaga gccggcgcag
    13021 caccgcctgc ttggcgaggc tgaactcctc gtcggtgagc accccgtccc ggtgcagctc
    13081 gcccagctcc cgcagccggc gcagcagcgc gtccgggtcg tcggcggagg cggcctgcgg
    13141 ggccggggcg ggcggcagcg ggagctgggc gggcgcctcg gccttgtcga gcgcgccggg
    13201 ggagcgctcc ggctcgcccc gggccgccag cgccaccagg accgccgccg cgaccagcac
    13261 ggccgtgtgc tccttcttcg acaggcccca caggtccagg gcgtgcgggt cgtgctcggg
    13321 tgccacggtc ttgccgccgc cggagcgggt gaggaagcgc aggtgcccgt tctccaggcc
    13381 ctgcgggggc acccaggcga ccccggtgag atcggcgagg gccagcgtgg tcgggccggc
    13441 ggaggtcttg gtctccttgc ccttccagtt ccaggtcagc cgcacctcgc gcccgtcgaa
    13501 ggcggccgtg ccgtccccgc cgccgcccga gaccggcagg gcgggaccgg gcagcaggaa
    13561 ccgctcgacc ggcccctcgg ggatctgctc cagcagcagt gcctggcgca cctcggccac
    13621 gaggtactcg gccaggtcct cccggcccgc ctcgaccacc agccggtacg ggtcggcgcc
    13681 ctcgggcagc cgtccctcgg cggcgcgcac caccgggcag gccccgtccc gcagccgcag
    13741 tctgagccgc ccgcccttgc ggtcccgctc gaaggtgatc ccggcgacgg ccgccagcgg
    13801 caccgcgacc tcgcccagca cctgccgtac cggatgggcc ttggcgcccg gcacgatccg
    13861 tatgcgcccg tcctcgtagc tccagctgcc gtcccgctgc gtgatctccg ccatgcgggg
    13921 attctttcag cacgaaggga acggcgggcg ccgcccgggg accgtacccg ggtggcgccc
    13981 gccgtggcgc ggggcggggc tcagcggccc gcgagggggt tgaccaggtc gccgacgagc
    14041 tggagggcgc ccgaggggtc ggccaggtcg accatctgct ggttgttgcg cagctggagc
    14101 cggttgaggc aggagagggc gaagctgggc gcgaacatgt cgtactgggc gaacttgtcg
    14161 gccagctgcg gcatggactc ctggtacgcg cggacgctct ccgccgccgt gcgccagaag
    14221 gtgtcctcgt cgaggacgcc ctcgccggcc agggtggcgt tgaggaagcg caggtagcag
    14281 tcgaagacgt cggtgaagat cgagaggatc ttcatctcct ccggcacctc ggccttgatg
    14341 cgctcgaccg cgggcggcag caccgcgtcc gggtccatga cgcagatctc ctcggcgatg
    14401 tccttgaaga tcacccggtc gaccgcgccg tcctcgatga cgaggatgac gttctcgccg
    14461 tgcggcatgt acaccaggtc gtactggtag aaggagtgca gcaccggcac gaggtaggcg
    14521 tccaggtagc ggcgcagcca cacctcgggg gccagccccg actcggcgat cagcgcgccc
    14581 gccagcgagg cgccgtcggc gtcggtgtgg agcagcgagg ccatggtggc cagccgctgt
    14641 ccctcgccga gctgcggcac cgggctctcc cgccagagcg cggccagcat cttgcggtac
    14701 ggcgagtacc ggtcggtggc ccgctcgtac tggcggtggt ggtagccgat ggcggcgcgc
    14761 tcgcggatga tcgagaagcg cgcggcccgg aagacctcgt caccggcgat gagctgggcc
    14821 agccagtcgt tgatcgccgg ggtggcctcc atgtaggcgg ccgacaggcc ccgcatgaag
    14881 cccatgttca gcaccgacat cgcggtcttc acgtagtgct tgtcggggtg gctggtgttg
    14941 aagaaggtcc ggatcgactg ctgcgcgagg tacgcgtcgt cgccctcgcc gagcaggacc
    15001 aggcgctgct gggcgacctc ggcggcgaag gagacggaga gcttgttcca ccactgccag
    15061 gggtggaccg gcagcaggtg gtagtcggcc aggtcgagcc cctggccggc cagggtggcg
    15121 gcgaaccggg ccagcgtcgc cgggtccagc tcgcccttga ccagcgtgtc gtagtcgagc
    15181 ccggcgccgc tggtgaaggt ggagcggtcg cggcgggcgg cgagccagag cagccggacc
    15241 ggggaggcgg tctcgggggc gtactggtgg tactcgcgga cgtcgaagcc gatccgcccg
    15301 ttgttggcga cgaagcaggg gtggccctcg gtcatccccg tctcgatggc ctggaagccg
    15361 gcgcgggcca gctcggcggc gctcgggcgg gcctgggcca gtttccaggc ggcgccggag
    15421 agggtggagg agatctcctc caggtagacc gggaggatgg cgtcgccgat gcccagcgcg
    15481 gtccgcgtgt cgaggatgaa gtcgagcgcg tccaggggga gttcggtgcc gccctcgccg
    15541 tgccgggtga tcgagtcggc ggcgatgtcc cagtggtcca ggctcagcag tttcgccgcg
    15601 aagcggtact cggtcacgcc gtcgtcggtc accacgcggt gggcggtgcg gccctcggcg
    15661 tcgggctcgg cgccgggcag cggctcgggc ttcagcagcc gctcgtggga gaactcggcg
    15721 aggcccttgc ggaccaggtg gcgcccggcg gcggcccaca gctccggggt gaggtgcgcg
    15781 gggggggcgg ccagctggtc ggtgggggtg gtgtcactca tcgggaagcc tgctccttcg
    15841 tgtcgtcccc cgccggtacg gtcgccgccg cttttttcgc cgcctcgaag gcgtcccggg
    15901 tgcagacgct caggtacgcc tccttctcgg gcttggcgat tttctcgacg atctcgaagc
    15961 cgacggcttc gttgagcgcg tggacggccg cgttgcgcac gtcgggctcg accacgacgc
    16021 ggacggtgtc cgggtcggcg aagaggtact ccatgaccgc gaagatcacc gcgcgggtga
    16081 agccgtgcag cggcgtgtcg gtcggcgcgc agaggaagtg catgccgacg tcgccgggct
    16141 cggggtcgta gaggccgacc agctccacgt gggcggggtc gtaccgctcc atgaggaagg
    16201 ccggggagtc ctcgtacagg ccgatgaagg cgtcgtggtg cgggtggtcg gcgatcgagg
    16261 cgtactcgcc gcggacctcg tcgacgctga gcccctgcat cagccagaag gccgatttcg
    16321 ggtgggtgac ccagccgtgg accaggccgg cgtcggcgtc caggtcgagg gggcgtatcg
    16381 cgagccggtc ggggcggact ttcgcggtgc ggggggtggt catacggaga actcctggaa
    16441 ggcgatcgac ttctccaccg cgtagggggc ggtgcccagc agctcgcgca ggatgacgga
    16501 gttgcggtag gcgcccatgc ccaggtcggg ggaggtgagg gcgtgggtgt ggactccggc
    16561 gttctgcacg aagatgccgc gcccggtggt gtcgatgctg tagttgcggg cgatgtcgaa
    16621 ccggccgcgc ccgtcccagc ggatgcggtc gcggaccggc tccaggaagt cggggacgcg
    16681 gtactggtag ccggtggcca gcaccaggcc ctcgctcgtc agctcgaagt ccttgccctg
    16741 ctcctcctgg cggagcccca gggtgtacgt accctcggac tcgtcccgtg cggcggtctt
    16801 cagggcggtg ttggtgagca gccgggtggg gacggggccg cgcacgttct tctcgtagag
    16861 caggtcgaag atggcgttga tgagttcgcc gtcgatgccc ttgaagaggt tcttctgctt
    16921 ctgctccagg ccgtagcggg tgtcctcggg cagcgcgtgg aagtagtcga tgtactccgg
    16981 ggaggtcatc tccagcgtga gcttggtgta ctccagcggg aagaaccggg gcgagcgggt
    17041 gacccagttc agctggtagc cgtggacgtc gatctcggcg aggaggtcgt agtagatctc
    17101 cgccgcgctc tggccgctgc cgaccagggt gatcgacttc ttggcctgga gggccgcttt
    17161 gtgctccagg tagcgggagt tgtgcagcag gtcgccgccg aggccctggc agggctcggg
    17221 gatgtgcggc ggggtgccgg tgccgagcgc caggtggcgg gcgcggtagg tgtcgccctg
    17281 gtcggtggtg acggtgtaga gcgcgctctc ctcgtcgtac gtcacctcgg tgacggtggt
    17341 cgagaagcgg accgagccga ggcgggcggc ggcccagcgg cagtagtcgt tgtactccgt
    17401 gcgcagcggg tagaagttct cccggatgta gaaggagtac agccgcccgg actccttcag
    17461 gtagttgagg aaggagtacg gcgaggtcgg gtcggccagg gtgaccaggt cggacatgaa
    17521 cggcgtctgg aggtgggcgc cgtccaggaa catgccggag tgccagtcga agtccggctt
    17581 cgtctccagg aagagcgcgt cgatctcgtc cagcggctcg gcgaggcagg ccagcccgag
    17641 gttgaacggg ccgaggccga tgccgagcag gtcgagcggc tcggcggagt cggaggcggt
    17701 gcgggacgat cgctcaagag gcgtggacaa gggactctcc caggtactgc tcggcgtggc
    17761 cggctatgag gtcgaggacg gcggcgatgt cggacgcctt cgtctcgggg ttgagaaggg
    17821 tgaacttgag gtagtgccgc ccgtccacct tggtgcccgc cacgacggcg tcaccggagg
    17881 cgaacagggc cttgcgggcg tacaggttgg cgcggtcgat ctgcgccggg tcggtgggct
    17941 ggccgggcag gtagcggaag accagggtgg agagcgaggg ctccacgacc acgtcgaagc
    18001 gcgggtcggc gacgagcagc ttccagccct cgccggcgag gtcgcagacc tcgtcgaaga
    18061 gctggccgat gccgtcggcg cccatcaccc ggagcgtcat ccacagtttc agggcgtcga
    18121 accggcgtgt ggtctggagc gacttgtcca cctggttggg gatgcgctcc tcggcggccc
    18181 ggcgcgggtt gaggtagtcc gcgtggtacg tggcgtgccg cagcgtggcg ccgtcgcgga
    18241 ccagcagcgc ggaggaactc acgggctgga agaaggactt gtggtagtcg acggtgaccg
    18301 agtcggcgtg ctcgatgccg ttcagcagag cgcgccgggt gggcgagacg agcaggccgc
    18361 agccgtaggc ggcgtcgacg tgcatccacg tgttgtgctg cgcgcacagc tcggcgatct
    18421 cgggcagcgg gtcgatcgag ccgaagtcgg tggtgccggc cgtgccgacg accgccatcg
    18481 ggaccaggcc ctcggcctcg cagcggcgca gctcggcggc gagcacctcg atccgcatcc
    18541 ggcgctcgcg gtcggtgggg atggtcacca ccgcgtccgg gccgaggccg agcagcgtcg
    18601 ccgacttgcg gacgctgaag tggctgacgt cggaggtgaa gacgcgcagc tgggtggggt
    18661 gcgccgcctt ggcctcctcg cgggcgagca gcatcgcctg gaggttggac tgcgagccgc
    18721 cgctggtgaa gacgccgtcc gcgccctcgc cgaggccgat ccggccggtc gtccagtcga
    18781 tgaggcgccg ctcgatgagg gtgccgcccg ccgactggtc ccaggtgtcc agggaggagt
    18841 tgaccgccga gaggaccgct tcgccgagca ccgccggaat gacgaccggg cagttgaggt
    18901 gagccaggta gcgcgggtgg tggaagtaga cggcgtcccg gaggtacacg tcggtcagct
    18961 cgtccagcgc ggcggtggtg tcgccgagcg gccggtcgag gtcgacggcg tcgaccacgg
    19021 gggcgagcgc ggccggggtg acgccggtga acgggctggt ggcacctgtc agcgatgcgg
    19081 ccacgcgctc gacaccttcg gtgacggagc ggcggtacgc ctccacgttc aggtcgttca
    19141 gcaggtgaga cctgggcgcg aggagactca tgagcggtcc tcccggtgag gggactagtg
    19201 atgctcctgg gggtgagcac cacagggggc gatgaactta ggtgagccta acctaatgtc
    19261 gacctgagga agtccacagg gggtgattcc cgtcaactgt ggccggatgc acagtgattg
    19321 gccgtgaagc gttcaccgga gcgccggctt tgcggccgaa gtgtccgcct tcgcacctct
    19381 tgttcgcgtg gtcggagttt ggggtgggcg tgtggggaac gtgtgcatat ctgacacctc
    19441 gtcagtcgtg tggaccgcaa agagccccgc ccacccctct tcggggtgcg cggggccggg
    19501 ttcctcaggc cgtacgccgt ttgccggtcg ccagcgactc cgcgcgcaac tgctcctcgc
    19561 tcgcgccctc acgccagtac ccgacgaagg tcaccgcccg ccggtcgaag ccgcgctcgc
    19621 ccaccaggtg gcggcggagc gtccgcatcc ggcccgcctc cccggcgatc cacgcgtacg
    19681 gctcgcccgc gggcagctcc gccgcccgga ccgcctccgc cgccgagggg gcaccctcgt
    19741 ccgtgaccag ccaggtgatc tcggcgtccg ccgcggtggc cagctcgcgc cggtcggcgg
    19801 cgtgcggcac ctcgatccac agccgcaccg ggaaaccggc cggcagccac tccaggatcg
    19861 cctcggtggc cggcaacgag gtcaggtccg cccacatcag cgcccaggcg gccgaggccg
    19921 gcggccggaa ccgcaccgac acgttctccg tcaccgccgg gcccagcacc acgacccggt
    19981 ccccgggcag cgcccgcgcc gcccaccggc aggccgggcc ggtgtcgccg tgcagtgcga
    20041 agtccacgtc gaactcggtg gtcccgtcgt cggcccgccg ttgcgcccgc acggtgtacg
    20101 agcgcatcac cgcccgctcc tgctcgggca tcgcccggta cgccgcccac cagttctcgc
    20161 ccgcctcgac cggcacccgc ggcacgcgct gccccgggtg cggcaggaag agcgagcaac
    20221 tctggtcccg gccgcccgac tcgaagagcg ccagctcctc gccgccgaag gtgagccgca
    20281 ccagcgaggg cgacaggcgt cggctgccgc gcacctccac gtcgaagaag cggaacggtg
    20341 tacgggcggg agcggtgggc gtggtggtca tgggacgggc cttccctcgg cgtcgaaatg
    20401 gcgctgaggt aagcctaacc ttagcgtgcg cgtggtggcg agagggggcg gcagaccgac
    20461 gggccgacgg ggagtccggt ggccgacagt gcacctcccc cctcgcagcg gtacgcggac
    20521 gcagccgtta cgggatcgct ctggtggggt caagtccccc ggcgctaggt tggtttcggt
    20581 cgcctgcggc ggcccgtacg ggtacgggcg ccacggtccc cggcggtcgt cagccgtccg
    20641 gtggccgaga cccgccccac cacccctcac ccccgtcctt ccgggagccg accgtgaacc
    20701 gccccccccc ccccgccatg accgcgctgg ccgtcgccgc cgggctctcc ctcgccgcct
    20761 gcgggggcgg gggcaccggc gaagagggcg agaagccgat cgccggcgcc gggcaggagg
    20821 gcggcgggaa gtccgcctcg cccaccgcct cgcccgaggc cggtccggac cggccgaaga
    20881 tcgaccttcc ggcggacctg accatgacct tcgagggcgg gaagagcggc gacgcggtca
    20941 aggacgccgt gctggccgac agcgccgagc ggatgcgcgc ggtcaacgcg gtcatcgcgg
    21001 gcaccgcccc cgagaacgtg ctcggccact acaacacggg caaggcgctg gaagcggcgg
    21061 cgagctgggt cggcgagttc gagaaggccg gggcgaccgt gaccggcgag gtccgctact
    21121 acgaccgtga ggtcacgctc gacggcaaga aggcggccac gctctccttc tgcgccgacg
    21181 agagcaaggg attcagcaag gacgccgaga ccggcaaggt cagcaagacg ccggtcagca
    21241 agaacagtta cgtcttctac aactcccggc tcgaacggaa cgacgccggg acgtggcaga
    21301 ccacgcagat cgtctcgaca cggggagcag gacagtgcca gccataggcc gaaagaccag
    21361 aggggtcgcg ctcggcgcgg cgctcttcct tctcgcgggc gccgcgcccg cctgggcgga
    21421 catcgtgccc ggcggcggta acggcagcgg ctcggagggc gaggtgggcg ggggaagcgg
    21481 cgacgacggc accatcaacg cctccgccgg agccgtcgtc tacgaccgct ccaagaacgg
    21541 ctccggccag tccgccggcc ccgtcacctc cgcctccgac tggacgcctc cggcctgcta
    21601 ctacgccccg gccttcaccc ccgaccagct gaaggccgag ctggagccca tctgggaggc
    21661 ggggtccacc ggtcccgagt gggacgccga gcagcgcgac cgctacgtga acggcaagcc
    21721 ctacaaggac ttcaacaagg agaaggaagg cgagggctac tggtgggacg gcttcgtcgc
    21781 cgacggcagg atcggtgatc ccggcgccct cgactgccag ggtccgaact tctgggtcga
    21841 caccggcgac gccccgcccg ccgacgtccc ggaggcgatc accccggaga tgctggccca
    21901 gctcgcctac gccgaactgc gcgtgccctc caccgaggtg aagctcgccc ccgaggtgga
    21961 gaccaaggtc aacctgccca cctgggcctg gctggacggt gccaccttca agcccgtctc
    22021 ggtcaccgcc tccgtgccgc tgctcggcat gacggccacc accaccgccg agccggtctc
    22081 cctgcgcatc gagcccggca cggccgacgc ccggctccac ccggcctccg gtgagtgcgc
    22141 cctggtcgac ggcagcatcg gcgagcgcta cgccaagggc aaggccgacc gcaccccgcc
    22201 gtgcggcgtg acctacctgc gctcctccgg cgacggcacc ttcccgctcc aggccaccct
    22261 gacctggaag atcagctgga ccggaaccgg cgtgaacgac gaacagccgt tgcccgacgg
    22321 ctccttcggt gcggaacagc cggtgaccgt gcgggagatc caggcggtca atcgctgatt
    22381 cccgccctca gcgcggcagc cccgcctccg cgatcgccag tacctcggtg atggcctcgc
    22441 ccggggtgcc ggtgcccggg gcggtgtgcc aggcccactc ctcgacggcc acgcggaggg
    22501 cggtgttgag cagggcggcc tggacgcggg gttccagggc gtccggggag cggccggtgc
    22561 gggccgcgag gacgcgggcg aggaccggtt cggccgcgtg gtggacctgg agccagaccg
    22621 cgcgcagccc cggttcggtg cggaccaggc ggaccaggtc gcgcagcgcc tgctcgtcct
    22681 cggcgagggc ggcggccgaa cggccgggcg ggtgcgtgct gatgccgtcg gtcagggtgc
    22741 gctcgcgcgg ccaggaggcg agccgttcgg cggccgcgtc cagggccgtg gtcagcagtg
    22801 ggccgacgca ctcctccttg gaggagcagt accgccacag ggtgcgcggg gagatcccgg
    22861 ccgccgccgc gatctcgtcg gcggtggtgg ccgcgacgcc ctgggccgcg aagaggcgga
    22921 ccgcctcgcg ggcgatctcc agccgcgtcg ccgccttgcg ccgctcggtc agtggcggcc
    22981 ggccgacccg ccgcccgtcc ttctccgccg tcacaccctc accccgtccc gcgcccggcc
    23041 gcacctgcgg tgatcctacg ccggtggccc gatcgtacgc ctttatggcg cgccctgcct
    23101 ttatggctca ctccgccatt aaagaggtac cgtcgatcgt gcacaccccc tgaacccagg
    23161 agcaccccat gagcagcacc accggcctcg cgggccgcgc cgtcgtcgtc accggagccg
    23221 ggtccggcat cggcagggcg gcggccctgc gcttcgccgc cgagggcgcc aaggtcctcc
    23281 tcgccgacct gaacggcgag gccgccgagg ccgccgcccg ggagatcacc gaggccggcg
    23341 gcaccgccgt caccgtcgcc ggggacctca gcgaccaggc cgtcgtcgac gaggtcgtcg
    23401 ccaccgccgt cgagcggttc ggctccctgg acgtcctcgt caacaacgcc gggatcatgg
    23461 accgcatgtc ggccgccggg gacaccgagg acgccgagtg ggagcgggtc gtgcgggtca
    23521 acctcaccgc cccgttcctg ctgacccgcg ccgcgctgcc gcacctgctc gccaccggca
    23581 agggcgccgt cgtcttcacc gcctccgagg cgtccctgcg cggcagcgcc gccggcgccg
    23641 cgtacaccgc cgccaagcac ggcgtcgccg ggctcaccaa gtccgtcgcc gtgatgtacc
    23701 gcgagaaggg cctgcgcgcc aacgccatcg cccccggcgg caccgccacc aacatccagg
    23761 tcgacgccga ccgcgaggcc cacggccccg ccgtcctcgg ctcctacctg cgcaacgtcg
    23821 gcagccccgc ccaggccgag gagcaggccg cggccatcgt cttcctcgcc tccgacgccg
    23881 ccagcaacat caacggggtg atcctcccgg tcgacggcgg gtgggccgcc gtctgagtcc
    23941 ccggcccgcc gtacggtcgt ccgtggtgaa gggtgcggcc ccgctccggg gccgcaccgc
    24001 agcgaccgcg cgaggagccg ccgtgaacca ggacgaggaa gagatccgcc gcctgatcga
    24061 ggagtgggcg tccgccgtcc accggggcga cctcgccgcc gtcgtccgcg accacgccga
    24121 cgacctcgtg atgtacgacg tcccgccccc gtacgagggg ctgcgcggcc tcgacgccta
    24181 ccgcgcggtg tggcccggct tcttcgcctg gcaggcgtcc ggcgccgagt tcaccctcga
    24241 caccctcgac gtcacggccg gccgggacgt cgcgtacgcc cacgccctcc tgcgctgcgg
    24301 cacccccgaa gaactcgccg aacgcccggc gctgcgcctg cggctgacgc tggggctgcg
    24361 caaggaggac ggccggtggg tggtcgccca cgagcatcac tcgttcccgg acctctcctc
    24421 ggagcccggc ccctcctcgt cgtagctgag caggtcgccg ggctggcact ccaggacccg
    24481 gcagatcgcg gtgagggtgg tgaagcggat cgccttggcg cggccgttct tcagcacgga
    24541 gagattgacg ttggtgacgc cgacgcgggc ggcgagttcg gccagcgtca tcgaacgggc
    24601 cgccaggagc cggtccaggt ggacctggat cgcgtggccg tcgtcctcag gcggcatcag
    24661 accaccgcgt ccagctcgtc gcgcaggagc gccgaggcgc cgacgatccg ggcgaaggtc
    24721 agcagaccga gcccggtgag gacggcgagg tagggggcgg accagagctg ggcccaggcg
    24781 gcgtcggcca cctcgtcgtc ggtgagggtg ccgagcagga ggccccccgc caccgacgcg
    24841 gccgtctcca cgacgaggct gccgagcagc agccaccagc cgaggacacg cagccgggcc
    24901 gccgtgcccc gcgtgtggac gccctcgcgc accgccagcc gcagcagccg gtccagcagg
    24961 tagagcccgc cgaccagcat caccgtcagg ggcgcggtgc gcagcacacc cagcacctgc
    25021 tgccaggtgg tcggttcctc ggcgcagaag cggggcgtgt agccgacctc cgcccccggc
    25081 aacggctcga aggggtggaa gtcaccgccg ctcgtggagg cccagtccac cgtgacgcac
    25141 aggtcccccc ggccccagtg caccccgtcg acgaacaggc tgagcaggaa acccgccacc
    25201 agcgccccga gcaggatgcg caaggtgacc gagacgacgc tggtcaacgg ctccagcatc
    25261 ttgcggtcct cggacatgac tgaccccccg tgggttcatg tttatcgata acatcgataa
    25321 acgataagag tccggggtcc ggccgtccag ccccggccgc cacctgtccc gccgcccggg
    25381 gttcgggcgc actccgctct cgggcgccct cctcctgatc gccgacggcc ggacgcacgg
    25441 cctggcccag gtcgccaggg ccgcccgcgc ctgacgcccg tcggtccctg tctggtcgcg
    25501 aacgatgacg ggacgtacgg agtcggcacg ggcatgctcg ctccggacct cggcctgttc
    25561 gcggcggcgg ggtgtgcccc gagcggctca ggcggacccg cccggcttct ccggcaccgg
    25621 cggcgccgtc agtccggcca ggacgaaggc ggtcaccgtc gccgtggccg ggaaggaggc
    25681 gttctccgcc acgcccttgg cggtcgggcg cccgtaggtc tccatgacca gggtgaacgc
    25741 gagggcgcac cgctcgctga cctcctgcgg ggacaggtcc ggcagggcgc ggccgacgcg
    25801 tacctcgaag ggggccgggg tgaaggcggt cgggacgttg gggagctggc ccgaggggag
    25861 ggccgcccgg gccaggaggt ggcacaggac ccggccgtcg cgcgtcgcga ccaggtcggc
    25921 gaagggctcg accagcccct ccaccaggcg acggacctcc tggaccccgg tcgcgcggct
    25981 ctcggagacg gcggcccagc gggagttcca gacgggcccc agctcctgtt ccagcagggc
    26041 cgagaccagg ccctcgcggg agccgaagtg gtagtggacc gcgcccgggt tgagtccggc
    26101 cgccgcgttg acggcgcgca gggagacctg gtcggccccc ttctccagga agagctgctt
    26161 ggccgccgcc aggaggcgct ggcgggtcgg ggcgtccgct tgggtcacgc cgcacattcc
    26221 atcacagccg ggagggcacg ggactcccgt tcaatcagtg attggattat gtttggaaag
    26281 cggggcaggg tcgcggaacg cgcccctccg cagcgatcag cagcaaggca aggagcacgg
    26341 ccatgggtac gtacgcggtc accggaagcg cctcgggcat gggagccgcc agcgcggccc
    26401 ggctgcggga ggccggacac cgggtcgtcg gcgtcgacct gcgggacgcc gacgtcaccg
    26461 ccgacctcgg caccgccgac ggacgccgcc acgccgccga cgagatcctg cggctctgcg
    26521 gcggggccct ggacggcgtc gccgccgtgg cgggcgtcgg cccgaacctc cccgacgcgg
    26581 ccgccgtcgc ctcgatcaac tacttcggcc ccgtcgccct cctcgacgcc ctgcgccccg
    26641 ccctggagcg cgaaggcggc ggccgggcgg tcgtcatcgg ctccaactcg gccaccaccg
    26701 tgccgatgat cgacgaccac ctcgtcggac tgctcctcgc cggcgacgag gaggccgccc
    26761 gcgcccacgc ggccggcgcg cagcgctccc tccccgccgc cctcgccgcc accagcccca
    26821 gcatcagcgc ctacgccacc tcgaagttcg ccctggcccg ctgggtacgg cggaccgccg
    26881 tcacccccga gtgggcccgg cgcggcatca ccctcaacac catcgccccc ggcgccgtcg
    26941 tcaccccgct gatgaccgac tccaccctct ccgaggacga cctcgacccg gacaccttcc
    27001 ccacgccgat gccgcgcggg atcttcggcc gccccgccga catcgccttc tgggtcgccc
    27061 agttcctcag ccccgaggcc ggattcacca ccggggcgac cctcaccgtc gacggcggca
    27121 cggacgccgc cat
//
