LOCUS       NZ_VOGX01000018        20975 bp    DNA     linear   CON 15-OCT-2024
DEFINITION  Streptomyces albidoflavus strain 77 scaffold11_cov50_1_2691061,
            whole genome shotgun sequence.
ACCESSION   NZ_VOGX01000018
VERSION     NZ_VOGX01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Draft Genomic Sequences of Streptomyces misionensis and Streptomyces
            albidoflavus, bacteria applied for phytopathogen biocontrol
  JOURNAL   Microbiol Resour Announc (2019) In press
REFERENCE   2  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Draft Genomic Sequences of Streptomyces misionensis and Streptomyces
            albidoflavus, bacteria applied for phytopathogen biocontrol
  JOURNAL   Microbiol Resour Announc (2019) In press
REFERENCE   3  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2019) Biology, UFLA, Universidade Federal de
            Lavras, Lavras, MG 37200000, Brazil
REFERENCE   4  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2019) Biology, UFLA, Universidade Federal de
            Lavras, Lavras, MG 37200000, Brazil
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-JUL-2019
            Assembly Method                   :: SPAdes v. 3.12
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 36.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007896905.1-RS_2024_10_13
            Annotation Date                   :: 10/13/2024 04:20:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,551
            CDSs (total)                      :: 6,456
            Genes (coding)                    :: 6,343
            CDSs (with protein)               :: 6,343
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 5 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 34 of 113
            Pseudo Genes (incomplete)         :: 81 of 113
            Pseudo Genes (internal stop)      :: 8 of 113
            Pseudo Genes (multiple problems)  :: 8 of 113
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:41:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2140766
            Orig. end                         :: 2161741
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VOGX01000018.1.
            Bacteria and source DNA available from MEB Lab.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20975
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="11"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20975
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20975
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10975](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10975)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    557..572
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.29"
                     /tool="antismash"
     misc_feature    582..597
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            755..1543
                     /locus_tag="FRZ02_RS11525"
                     /old_locus_tag="FRZ02_11525"
     CDS             755..1543
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950769.1"
                     /locus_tag="FRZ02_RS11525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11525"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_003950769.1"
                     /transl_table=11
                     /translation="MTTDAGGTRTRTADEPATEPTSPVRATRVPKYYRLKRHLLDMTRT
                     LPPGTSVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLT
                     SYTEDMRAQGLEPTSQLLEVGYITADDSLASLLDITAGGRVLRIERLRLASGEPMAIET
                     THLSAKRFPALRRSLVKYTSLYTALYEVYGVRPAEAEETIETSLATPREAALLATDVGL
                     PMLMLSRHSRDESGAPVEWVRSVYRGDRYKFLARLKRPVE"
     gene            2044..4266
                     /locus_tag="FRZ02_RS11530"
                     /old_locus_tag="FRZ02_11530"
     CDS             2044..4266
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0009267 - cellular response to starvation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1185: carbon
                     starvation protein A"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642402.1"
                     /locus_tag="FRZ02_RS11530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11530"
                     /product="carbon starvation CstA family protein"
                     /protein_id="WP_146580989.1"
                     /transl_table=11
                     /translation="MAEPAPPASGNRKLSAKSIAVWSLVAVVGAIAWSVLALSRGEEIS
                     AIWMLAAALGSYAIAYRFYSRFIANKVLKVDKNRATPAERLDNGVDFQPTDRRVLFGHH
                     FAAIAGAGPLVGPILAAQMGYLPGTIWIVAGVIFAGAVQDMVTLFFSTRRNGRSLGQMA
                     RDEIGPVGGVAALIAVFIIMIILLAVLALVIVNALAGSPWGVFSIGMTIPIALFMGVYL
                     RTLRPGKVTEVSVLGVALLLLAIVGGGWVAESSMADFFTLEPGTLVIWMVVYGFFASVL
                     PVWMLLAPRDYLSTFMKVGTIVLMAVCVIIAMPTLKMDGVTSFATSGAGPVFSGSLFPF
                     VFITIACGALSGFHSLVSSGTTPKMVQKETQIRMIGYGAMLTESFVAIMAMIAACIIDP
                     GLYFAINSPAGVLGDTVQSASEAVANLGFTISPDQLAQAAKDVEEASLLSRTGGAPTFA
                     LGMAEIFAAALGGAGMKAFWYHFAIMFEALFILTTVDAGTRVGRFMLQDTLGNVWKPMR
                     RVSWWPGVWLTSAIVVGCWGYFLWVGVHDPLGGINQLFPLFGIANQLLAAVALAVCTTL
                     LIKSGRLKWAWVTGIPLAWDVAVTLTASWQKVFSDNPAIGFFAQRAKYQDGIDAGEVLA
                     PAKSMSDMHTVVTNSTVDGVLSIVFAVLIIIVLVDAGRVSYNAIRKPESVKLAEAPFEQ
                     SKIVAPAGMFATSEEKAELALVGAGAPASAGDGDGDAPAKQGGGQA"
     gene            4263..4505
                     /locus_tag="FRZ02_RS11535"
                     /old_locus_tag="FRZ02_11535"
     CDS             4263..4505
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642403.1"
                     /locus_tag="FRZ02_RS11535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11535"
                     /product="YbdD/YjiX family protein"
                     /protein_id="WP_003950767.1"
                     /transl_table=11
                     /translation="MSGEAAHHPGRLGVLAHRVRAGVRWIGWYVREVSGETAYEKYAAH
                     VRRHDPDAEVMTRRQFERSRMDAREADPRDGFRCC"
     misc_feature    4818..4832
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.01"
                     /tool="antismash"
     misc_feature    4849..4863
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    4857..4870
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     regulatory      4885..4961
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            5123..7498
                     /locus_tag="FRZ02_RS11540"
                     /old_locus_tag="FRZ02_11540"
     CDS             5123..7498
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966408.1"
                     /locus_tag="FRZ02_RS11540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11540"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_008415719.1"
                     /transl_table=11
                     /translation="MTIAPADPSTAEVRAEEIQGPGGALLRTLTDLTADLPDTDPGRVA
                     AAALRGRNAASDEAELRSLATEAAAGLISEDPAYSRLAARLLTRTIAEEAAGQGVTTFT
                     ESVATGHREGLIADRTAAFVTAHAERLDALVDPAADDRFGYFGLRTVHSRYLLRHPHTR
                     QVIETPQHFMLRVACGLAEDDSARALDEVASLYRLMSALSYLPSSPTLFNSGTRHPQMS
                     SCYLLDSPKDELESIYDRYHQVARLSKHAGGIGLAYSRIRARGSLIRGTNGHSNGIVPF
                     LNTLDASVAAVNQGGRRKGAAAVYLETWHADVEEFLELRDNTGEEARRTHNLNLAHWIP
                     DEFMRRVDADADWSLFSPSDVPELTDLWGDAFDAAYRAAEARGLARRTIPARELYGRMM
                     RTLAQTGNGWMTFKDASNRTANQTALPGHTVHSSNLCTEILEVTDDGETAVCNLGSVNL
                     GAFVDGGAIDWERLDEAVRTAVVFLDRVVDINFYPTEQAERSNSRWRPVGLGAMGLQDV
                     FFQLRLPFDSPEAQRLSTRIAERIMLTAYETSCDLAEKNGPLPNWDRTRTAQGVLHPDH
                     YDTDLAWPERWEALRARVAESGMRNALLLAIAPTATIASIAGVYECIEPQVSNLFKRET
                     LSGEFLQVNSYLVEDLKRLGVWDARTREALREASGSVQGFAWIPEELRALYRTAWELPQ
                     RGLIDMAAARTPFLDQSQSLNLFMETPTIGKLSSMYAYAWKKGLKTTYYLRSRPATRIA
                     RAAGGSAPATATVPAQAAPDAEAIACSLENPESCEACQ"
     gene            7498..8550
                     /locus_tag="FRZ02_RS11545"
                     /old_locus_tag="FRZ02_11545"
     CDS             7498..8550
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346718.1"
                     /locus_tag="FRZ02_RS11545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11545"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_003950764.1"
                     /transl_table=11
                     /translation="MTTPDTTPAANAHTVGAAKNLLDPGFELTLRPMRYPDFYERYRDA
                     IKNTWTVEEVDLHSDVADLAKLSPGEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSP
                     EARLYLSRQLFEEAVHVQFYLTLLDTYLPDPADRADAFAAVENIPSIREKAEFCFRWMD
                     SVDKLDQLESQADRRKFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWV
                     FRDETMHMSFAFDVVDTVRKEEPELFDDKLQEQVVAMLKEAVEAELQFARDLCGDGLPG
                     MNTESMREYLECVADQRLTRLGFAPVYGSQNPFSFMELQGVQELTNFFERRVSAYQVAV
                     EGTVSFDDDF"
     gene            complement(8637..10004)
                     /locus_tag="FRZ02_RS11550"
                     /old_locus_tag="FRZ02_11550"
     CDS             complement(8637..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950763.1"
                     /locus_tag="FRZ02_RS11550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11550"
                     /product="cytochrome P450"
                     /protein_id="WP_008415717.1"
                     /sec_met_domain="p450 (E-value: 2.2e-78, bitscore: 261.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAESTTERPAAPGPRTPPLVAGSVPVLGHAPSLVRDPLAFLTGL
                     RDHGDLVRVKLGPKTAYAVCAPELVGALLRNSQEFQVGGPLWENLEVLLGKGVATSNGA
                     DHRRQRRMMQPAFRPERIASYATVMEEEARAMADRWQDGQVVDIGAETFSCAVRVVARS
                     LLEVDSIGAKADRISASLHTVFSGLYRRMILSFGPLHRLPTPANRRFERALADLHHLVD
                     EVIAERHAQGKGADDLLDILLTSEDGEGRPLGDQEIHDHLVSLIVAGAENVASTLAWCF
                     QLLTEHPAEEQRVAEEALSVAPDRPVNFGDLGSLDHTRNVIVESMRIRPAAWIFTRRAV
                     ADTELGGYRIPAGADIIYSAYAMQHDPRSFDRPDVFDPDRWIPERAEKVPQYAMMPFST
                     GNRKCPGDHFSMVEATLMLATVLPRWRLVPVPETDPAPRIGITLQPKRAVFRVESR"
     gene            complement(10001..10975)
                     /locus_tag="FRZ02_RS11555"
                     /old_locus_tag="FRZ02_11555"
     CDS             complement(10001..10975)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470738.1"
                     /locus_tag="FRZ02_RS11555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11555"
                     /product="multidrug MFS transporter"
                     /protein_id="WP_033238136.1"
                     /sec_met_domain="T1TS (E-value: 5.1e-52, bitscore: 174.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESRAWLLEKRLMPADKVTRYADELRYTDLIAGYYVGAPKDVISA
                     ISDFSTWFFVWDDQHDRDAVHGRRTAWYRLSAELHTALDAPGDHLAHPEPLVAAFAETV
                     HRLNGFLGPAWNERFARHFHAIVGAYDQEFENRVTKVTPKVAEYIELRRHTFGHSVWID
                     LLEPTAGREIPADLRTSGPFLAAARHCQDFSAWYNDLCSLPKELAGDDQHNLGISLIRH
                     EGLSLEEAVVEVRKRVENCVTEFEVAEKELRELLAGHLAALPGGAGTAEARSVAEAVGS
                     AVFNMRNWFSSVYWFHHESGRYRVDSWDDRSTPPYVSDLAGDA"
     misc_feature    complement(11011..11024)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.14"
                     /tool="antismash"
     misc_feature    11011..11024
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.17"
                     /tool="antismash"
     misc_feature    11257..11271
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.73"
                     /tool="antismash"
     gene            complement(11363..12019)
                     /gene="def"
                     /locus_tag="FRZ02_RS11560"
                     /old_locus_tag="FRZ02_11560"
     CDS             complement(11363..12019)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="FRZ02_RS11560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11560"
                     /product="peptide deformylase"
                     /protein_id="WP_003950761.1"
                     /transl_table=11
                     /translation="MAQQDTEQQAVAGGVLPVDDEGFVIDTEDTEEREAAYRARGTARP
                     ITVVGNPVLHRETKDVTVFDAELAQLVDDMFASQRAAEGVGLAANQIGVDKKVFVYDCP
                     DDEGARHVGVVCNPVLDELPSERRVLDDSNEGCLSVPTAYAELARPDYAVVRGQDEKGN
                     PIVVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAEGTPRYETVPND"
     gene            complement(12112..13104)
                     /locus_tag="FRZ02_RS11565"
                     /old_locus_tag="FRZ02_11565"
     CDS             complement(12112..13104)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415712.1"
                     /locus_tag="FRZ02_RS11565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11565"
                     /product="hypothetical protein"
                     /protein_id="WP_008415712.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARTAGLRAVALLDRDTGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKIPGDAAASGEPSGMGLGSAAVRISPEGEAEVVWGRRLDPARIEVQSIPL
                     PSSGRRWGEVILHDGVPHGERTTASGDTYPVFDEIELWAPSPVPTWVVLLEAQAPADRD
                     ALELLAADAGFAAEDWSSSVRLLCRTCSESRMPSDEGGGERHVDPHDHSEPGQPGPLGH
                     RTTSGEGDLWVPERECGIAAPPALVRGLLDGWVADSPDTRAWRDLEEVC"
     gene            complement(13339..13647)
                     /gene="rsrA"
                     /locus_tag="FRZ02_RS11570"
                     /old_locus_tag="FRZ02_11570"
     CDS             complement(13339..13647)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642406.1"
                     /locus_tag="FRZ02_RS11570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11570"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_003950759.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDHEMPDSDSNKIRTHFDECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPADLRDKVISRLDMIRAGQAVPQHDIVPTEVADTP"
     gene            complement(13644..14318)
                     /locus_tag="FRZ02_RS11575"
                     /old_locus_tag="FRZ02_11575"
     CDS             complement(13644..14318)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="FRZ02_RS11575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11575"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_026048295.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGSQDVPEKPEETSAERTARFERDALAFLDQMYSAAL
                     RMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQRS
                     AAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKSALQAIPEEFRIAVYLADVEG
                     FAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGSGASAAEPNERKGA
                     GS"
     misc_feature    14510..14524
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(14696..15382)
                     /locus_tag="FRZ02_RS11580"
                     /old_locus_tag="FRZ02_11580"
     CDS             complement(14696..15382)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415707.1"
                     /locus_tag="FRZ02_RS11580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11580"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_391595623.1"
                     /transl_table=11
                     /translation="MNVARSEGVGVPAVPAAGERVSVATDVGEARVTWVRAEVPRVVLA
                     LGHGAGGGIEARDLVALAGVWPGAGVSVALVEQPWRVAGKKVAPAPKTLDKGWEAVWGE
                     VAGEGLPVVAGGRSAGARVACRTGAELGAAGVLALSFPLHPPGKPERSRAGELLGTGVP
                     TLVVQGGRDPFGRPEEFPGGSYELAEVAYGDHGFAVPKKAPVGQEEALRVITDAVGAWI
                     ERLPVG"
     gene            complement(15639..16511)
                     /locus_tag="FRZ02_RS11585"
                     /old_locus_tag="FRZ02_11585"
     CDS             complement(15639..16511)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611243.1"
                     /locus_tag="FRZ02_RS11585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11585"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_008415704.1"
                     /transl_table=11
                     /translation="MCGRYAATRSPEDLSEIFGVEKTELSEAAEGQEDGHEAGASPVPT
                     ETLVPDWNVAPTKEVPAILDRPVKGSDDPRPVRQLRMLTWGLVPSWATSPDGGARMINA
                     RAETVHEKPAYRRAFASRRCILPADGYYEWVTAPEERKLEEEGKRKRARKQPYFVTPAD
                     GSVFAMAGLYEFWRDPSLPGDHPRAWWVTCSVLTTEAETAPLGVGPAEGPRALADIHPR
                     MPLMLTPDKWDAWLDPSKTDVGEVRELLGAPPEGLMRAYPVATAVSNVRNNGPGLVSEL
                     DGPEVGTLF"
     gene            16601..17323
                     /locus_tag="FRZ02_RS11590"
                     /old_locus_tag="FRZ02_11590"
     CDS             16601..17323
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950755.1"
                     /locus_tag="FRZ02_RS11590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11590"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_003950755.1"
                     /transl_table=11
                     /translation="MQSTTAAPATDLWDRVTGTQTAPEFWLVVATGVAALAVVLWGPAW
                     RTARNAITIAHEGGHGLIALVTGRTLEGIRLHSDTSGLTVSRGRPTGPGMILTALAGYT
                     APSLLGLGGAWLLASGHITLLLWVATALLLALLVMVRNAYGVLTVLITGGLFVAVSWLA
                     GSEVQALFAYAAVWFLLLGGVRPVFELQSKRRRGGAPDSDADQLARLTHAPAAIWLFLF
                     HAVALCSLIGGGGWLLGR"
     gene            17366..18718
                     /gene="aroA"
                     /locus_tag="FRZ02_RS11595"
                     /old_locus_tag="FRZ02_11595"
     CDS             17366..18718
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642411.1"
                     /locus_tag="FRZ02_RS11595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11595"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_003950754.1"
                     /transl_table=11
                     /translation="MTLNPVSTPLWPAPYATGAVEATVQVPGSKSVTNRALVLAALAAE
                     PGWLRRPLRSRDTVLMAEALRTLGVGIEETVSSDSAAPGSTLAKGGEAWRIIPSGLRGP
                     ATVDVGNAGTVMRFLPPLATLADGDIRFDGDPRSYERPLHGVIDALRALGARIDDDDRG
                     SLPMTVHGTGSLDGGTVEIDASSSSQFVSALLLSAPRFNQGVEVRHIGPRLPSMPHIRM
                     TVDMLRRVGAQVDEPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGRV
                     VVPDWPAHTTQPGDRLREIFTTMGGSCELTEAGLVFTGSGRVHGIDVDLGEVGELTPGI
                     AAVAALADGESVLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLRIRPRPLHGGV
                     FHTYDDHRMATAGAILGLVVKGVEIENVATTAKTLPDFPDLWTGMLDGTGQ"
     gene            18736..19752
                     /gene="rsgA"
                     /locus_tag="FRZ02_RS11600"
                     /old_locus_tag="FRZ02_11600"
     CDS             18736..19752
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966421.1"
                     /locus_tag="FRZ02_RS11600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11600"
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="WP_003950753.1"
                     /transl_table=11
                     /translation="MRRYGKNPDEDDIRVRPSRRGSRPRTHTRPKHEDAAEGMVLTVDR
                     GRITCLVEGRTVTAMKARELGRKAAVVGDRVALVGDLSGQKDTLARIVRIEERASVLRR
                     TADDDDPYERVVVANADRLAIVTALADPEPRPRMIDRCLVAAYDGGLEPVLVLTKSDLA
                     SPDSLLDTYRALGVPYVVTSREELEDGSAVERVRELLDGHVTAFVGHSGVGKTTLVNAL
                     VPEEQRRVTGHVNAVTGRGRHTTVSALALPLADAAPGSWVIDTPGVRSFGLHHVDPSRV
                     IHAFPDLEPGTEECPRGCSHDEPECALDQWVADGHADPARLNSLRRLLATRERREGD"
     gene            19880..20203
                     /locus_tag="FRZ02_RS11605"
                     /old_locus_tag="FRZ02_11605"
     CDS             19880..20203
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950752.1"
                     /locus_tag="FRZ02_RS11605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11605"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_003950752.1"
                     /transl_table=11
                     /translation="MAWLLVVVAGLLETGFAVCLKLSHGFTRLWPTIAFAAFALGSFGL
                     LTLALKRLDVGPAYAVWTGIGAAGTATYGMIFLGDVVSVLKIVSITLVICGVIGLQLSG
                     SAQ"
     gene            complement(20169..20786)
                     /locus_tag="FRZ02_RS11610"
                     /old_locus_tag="FRZ02_11610"
     CDS             complement(20169..20786)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893589.1"
                     /locus_tag="FRZ02_RS11610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_11610"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_146580991.1"
                     /transl_table=11
                     /translation="MSEVRAALLIAAEAHLARRPWSAVRMGEVAASAGVSRQTLYNEFG
                     SKEGLARALARQAADGYLAGIERALARSAADPRERLRAAADWTVAAARPGTLLRSLLTG
                     CWGDPLPAPRPARTTATAPAQRRAELPLPGPGDLLAAARDRAVAALDGAAPRTDPRELA
                     RECECVLRLALSRVVAPPVVGGGGAGRRRGRVTGPSPRAGGR"
ORIGIN
        1 gtagaccgcg acgcgggcac cggcgtagta aggcacgcag tactgcttgc cctcgaaggt
       61 gcaggtgtcg gtgaggccct ggatccaggt gtccgagttc tcgtacttct tggggtcgat
      121 ctcggcgagg gcgccgttga ggatgtactg catcgtctcg gtgttgccca gctcgacgac
      181 gtccgggaac ttgtccccgc cgagcgcggt gtcgagcttc ttggccttgt cggcccagcc
      241 ctggtactgg acgttcacct tgacattggg gtacttcttc ttgaactgcg cgttgacgtc
      301 cttgaccagc tccggccagg tgctctgggc gtcgaccatc agccagacgg tcaggttttc
      361 cttgcggtcc tcgggcttgg cgttgctcgc cgtctccgag tccccgcacg ccgcgagacc
      421 ggccatcatg ccagcgacac cgatggccgc aatgagcttg cgcttcacgt caccctcctc
      481 agggaaccct ctacccccca cccgcagcga tgacatcgaa gacgagttac tgccgtggga
      541 ctgggatctg gtctttaatg gtgtagacca gtaagccgga gcttggccta gacctttagg
      601 ggtgtcaagg gtgtataaga agggcagtca cgtccgttat cggaccgaca cctgagggag
      661 tccggaccgg cgatcaccgg ccgtgccacg atgtgatccg cgacagacgg aggagccggt
      721 gacggcagca gcacaggagc cggagaggcg gaccatgacg acggacgcgg gcggtacgag
      781 gacccggacg gccgacgagc ccgccaccga accgaccagt ccggtccggg ccacgcgggt
      841 gcccaagtac taccgtctca agcggcactt gctcgacatg acgcggacgc tgccgccggg
      901 cacctccgtg ccccccgagc gtacgctcgc cgccgagttc gacacctcgc ggaccacggt
      961 gcgccaggcg ctccaggagc tggtggtcga gggccggctc gaacgcatcc agggcaaggg
     1021 caccttcgtc gccaagccca aggtctccca ggcgctccag ctgacctcct acaccgagga
     1081 catgcgcgcc cagggcctgg agcccacctc gcagctgctg gaggtcggct acatcaccgc
     1141 cgacgactcc ctcgcctccc tgctcgacat caccgcgggc ggccgcgtgc tgcgcatcga
     1201 gcggctccgg ctggccagcg gcgagccgat ggcgatcgag accacccacc tctccgccaa
     1261 gcgcttcccc gccctgcgcc gctccctggt caagtacacc tctctctaca cggcgctcta
     1321 cgaggtctac ggggtgcgcc cggccgaggc cgaggagacc atcgagacct cgctcgccac
     1381 cccgcgcgag gccgccctgc tcgccaccga cgtgggcctg ccgatgctca tgctctcccg
     1441 ccactcccgc gacgagagcg gcgcgccggt ggagtgggtg cgctcggtct accgcggcga
     1501 ccggtacaag ttcctggccc gcctgaagcg gccggtggag taggaccggc gcacggagga
     1561 cagcggggcg gcacccctca ccggggatgc cgccctttcc catgtccggc atacgggccg
     1621 acgggtaacc ccggggtact tggcaggaaa tcgaagcccg ttttccggcc acccggtaat
     1681 gaccccactc gcccccgcct gagccccgcc gggcaattcg ctcgtacgtg tgtgcttttc
     1741 cgcgcatgac cacggggcgg cgcggggtac gcacctcccc ggcggaaggt cacggttggg
     1801 gggtgatcgg cgaagggccg ctcgggcggg gcgcccgccc cgcgggggac aaatgcgcgg
     1861 ggaggcgtgc gtaaggggcg gggacgcgac ggccacggct cagggttgcg ccggatgtga
     1921 agtcgttgcc gttccgatac gcggacaggg ggtgtcaaag cccggacctg tcgcctacat
     1981 ttccgacgca ttgcaggagt tcagcgcagg tgtttccgcc agcgctcatg tgaggggacc
     2041 atcatggccg agccggctcc acccgcctcc ggaaaccgga agctgtccgc caaatccatc
     2101 gccgtctggt cgttggtcgc cgtggtcggc gccatcgcct ggagcgtact ggcgctctcc
     2161 cggggcgagg agatctccgc catctggatg ctggcggcgg ccctcggctc gtacgccatc
     2221 gcgtaccgct tctactcgcg gttcatcgcc aacaaggtcc tgaaggtcga caagaaccgg
     2281 gccaccccgg cggagcgcct ggacaacggc gtcgatttcc agccgacgga ccgccgggtg
     2341 ctcttcggcc accacttcgc ggcgatcgcg ggtgcgggcc cgctggtcgg cccgatcctg
     2401 gcggcccaga tgggctacct gccgggcacc atctggatcg tggcgggcgt gatcttcgcc
     2461 ggtgccgtcc aggacatggt caccctcttc ttctccaccc ggcgcaacgg ccgttcgctc
     2521 ggccagatgg cccgggacga gatcggcccg gtcggcggtg tcgccgccct gatcgcggtc
     2581 ttcataatca tgatcatcct gctggcggtg ctggccctcg tcatcgtcaa cgcgctggcc
     2641 ggctcgccgt ggggtgtctt ctccatcggc atgaccatcc cgatcgccct cttcatgggc
     2701 gtctacctgc gcacgctgcg ccccggcaag gtcaccgagg tctccgtcct cggcgtcgcc
     2761 ctgctgctgc tggcgatcgt gggcggcggc tgggtcgccg agtcctccat ggcggacttc
     2821 ttcaccctgg agccgggcac cctggtcatc tggatggtgg tctacggctt cttcgcctcg
     2881 gtgctgccgg tctggatgct gctcgccccg cgtgactacc tctccacctt catgaaggtc
     2941 ggcacgatcg tgctgatggc ggtctgcgtc atcatcgcga tgccgacgct gaagatggac
     3001 ggcgtcacct ccttcgcgac cagcggcgcg ggcccggtct tctccggctc gctcttcccg
     3061 ttcgtcttca tcaccatcgc ctgtggcgcg ctctccggct tccactccct ggtctcctcg
     3121 ggcaccaccc cgaagatggt ccagaaggag acccagatcc ggatgatcgg gtacggcgcg
     3181 atgctcaccg agtcgttcgt cgccatcatg gcgatgatcg ccgcctgcat catcgacccg
     3241 ggcctctact tcgcgatcaa ctccccggcc ggcgtcctcg gtgacaccgt ccagagtgcc
     3301 tcggaggcgg tcgccaacct cggcttcacc atcagcccgg accaactggc ccaggcggcg
     3361 aaggacgtcg aggaggcctc gctgctgtcg cggaccggcg gcgcgcccac cttcgccctc
     3421 ggtatggccg agatcttcgc ggccgcgctg ggcggcgccg ggatgaaggc gttctggtac
     3481 cacttcgcga tcatgttcga ggcgctcttc atcctcacca ccgtcgacgc cggtacgcgg
     3541 gtcggccgct tcatgctcca ggacaccctg ggcaacgtct ggaagccgat gcgccgcgtc
     3601 agctggtggc cgggcgtctg gctgacctcg gcgatcgtcg tcggctgctg gggctacttc
     3661 ctctgggtcg gcgtccacga cccgctgggc ggcatcaacc agctcttccc gctcttcggt
     3721 atcgccaacc agctgctggc cgccgtcgcg ctggccgtct gcaccacgct gctgatcaag
     3781 tcgggccgcc tcaagtgggc ctgggtgacg ggcataccgc tcgcctggga cgtggccgtg
     3841 acgctcaccg cgagctggca gaaggtcttc tcggacaacc cggcgatcgg cttcttcgcc
     3901 cagcgcgcca agtaccagga cggcatcgac gcgggcgagg tgctggcccc ggccaagtcg
     3961 atgagcgaca tgcacaccgt ggtgaccaac tccaccgtgg acggcgtcct gtccatcgtc
     4021 ttcgcggtgc tgatcatcat cgtcctggtc gacgcgggcc gcgtcagcta caacgcgatc
     4081 cgcaagcccg agtcggtcaa gctggccgag gcgcccttcg agcagtcgaa gatcgtcgcc
     4141 ccggccggga tgttcgccac ctccgaggag aaggccgaac tggccctcgt cggcgccgga
     4201 gcccccgcct ccgccggtga cggcgacggc gacgcccccg cgaagcaggg cggcggccag
     4261 gcatgagcgg cgaggcggcc caccaccccg gacgcctcgg cgtcctggcc caccgcgtac
     4321 gcgccggcgt ccgctggatc ggctggtacg tccgggaggt gtcgggcgag acggcgtacg
     4381 agaagtacgc cgcgcacgtc cggcgccacg acccggacgc cgaggtgatg acccgcaggc
     4441 agttcgaacg cagtcgcatg gacgcccgcg aggcggaccc gcgcgacgga ttccgctgct
     4501 gctgaccgcc ggatgaagcc gccggccccc gaacgagggg gccggcggct tcgccgtttc
     4561 ccgggccggg ggccctgacg accgccgcac cggtccgggc gcgtacgctc tgcgaggtcg
     4621 ccgtggagct ccgcgcgccg cccgtgagtt cccgccgggc ccggccccgg ggcgttcccc
     4681 tccggggcgc cgacggcccc tcaggagccc gccggcgacc tgtccgacgg ggacccggac
     4741 cccgtccgcg gccgcctccg cgaggttcgg gcatccggtg cgggtggggt cgaatgaccc
     4801 acctcacagc acacccgaca caagatatgg ggccgcttcg cgagcgcggc acaagatgta
     4861 tgctcatgct cgctgtcgcc gcaggggaat ccggtggaag tccggaactg tcccgcaacg
     4921 gtgtgttggt gcgctttcgc gtacccgcga gtccgaagac ctgccgaaca gcgcacccgg
     4981 ccgtccggtc cgggtgccga tgtcgtccgg gcctcgtgga atgggctcgc ggacgcgtgc
     5041 ggagccgtgt gccctcgagc ccggcgtccc gcccgtaccc gctgccctcc gcgaggctcc
     5101 gagccgagcg agggagagct tcatgaccat cgcgccagcc gatccgtcga cggccgaggt
     5161 gcgggccgag gagatccagg gccccggggg cgcgctgctg cgtaccctca ccgacctcac
     5221 cgcggatctc cccgacaccg accccggccg ggtcgccgcc gccgcgctcc ggggccgcaa
     5281 cgccgcctcg gacgaggccg agctgcggtc gctcgcgacg gaggccgccg ccggtctgat
     5341 ctccgaggac cccgcctact cccggctcgc cgcccgcctg ctgacccgca ccatcgccga
     5401 ggaggccgcg ggccagggcg tcaccacctt caccgagtcg gtcgccaccg gccaccgcga
     5461 gggcctgatc gcggaccgca ccgccgcctt cgtcaccgcg cacgccgagc ggctcgacgc
     5521 tctggtcgac ccggcggccg acgaccgctt cggctacttc ggcctgcgca ccgtgcacag
     5581 ccgctacctg ctgcgccacc cgcacacccg ccaggtcatc gagacgcccc agcacttcat
     5641 gctccgcgtc gcctgcggcc tcgccgagga cgactcggcg cgggccctcg acgaggtcgc
     5701 ctcgctctac cggctgatga gcgccctctc ctacctgccc tcctccccca ccctcttcaa
     5761 ctccggcacc cggcacccgc agatgtcctc ctgctacctg ctggactccc ccaaggacga
     5821 gctggagtcg atctacgacc gctaccacca ggtcgcccgg ctctccaagc acgccggcgg
     5881 catcggcctc gcctactccc gaatccgcgc ccggggttcg ctgatccgcg gcaccaacgg
     5941 gcactccaac ggcatcgtgc cgttcctcaa cacgctcgac gcctcggtgg ccgcggtcaa
     6001 ccagggcggc cggcgcaagg gcgcggccgc ggtctacctg gagacctggc acgccgacgt
     6061 cgaggagttc ctggagctgc gggacaacac cggcgaggaa gcccggcgca cccacaacct
     6121 caacctcgcg cactggatcc cggacgagtt catgcgccgg gtcgacgccg acgccgactg
     6181 gtcgctcttc tccccctcgg acgtccccga gctgaccgac ctgtggggcg acgccttcga
     6241 cgcggcctac cgcgcggccg aggcgcgggg gctggcccgg cggaccatcc cggcgcgcga
     6301 gctgtacggc cggatgatgc gcaccctcgc gcagaccggc aacggctgga tgaccttcaa
     6361 ggacgcctcc aaccgcaccg ccaaccagac ggcgctgccg ggccacaccg tgcactcctc
     6421 gaacctgtgc acggagatcc tggaggtcac cgacgacggc gagacggccg tctgcaacct
     6481 cggctcggtc aacctcggcg ccttcgtcga cggcggcgcg atcgactggg agcggctgga
     6541 cgaggcggtg cgcaccgccg tcgtcttcct cgaccgcgtg gtcgacatca acttctaccc
     6601 gaccgagcag gccgagcgct ccaactcccg ctggcggccg gtgggcctgg gcgcgatggg
     6661 gctccaggac gtcttcttcc agctccggct gcccttcgac tcccccgagg cccagcggct
     6721 ctccacccgg atcgccgagc gcatcatgct caccgcgtac gagacctcct gcgacctcgc
     6781 cgagaagaac ggcccgctgc cgaactggga ccgcacccgc accgcccagg gcgtgctcca
     6841 cccggaccac tacgacaccg acctggcctg gccggagcgg tgggaggcgc tgcgcgcccg
     6901 ggtcgcggag agcggcatgc ggaacgcgct gctcctcgcc atcgccccga cggccaccat
     6961 cgcctcgatc gccggtgtct acgagtgcat cgagccgcag gtctccaacc tcttcaagcg
     7021 cgagacgctg agcggggagt tcctccaggt caactcctac ctggtggagg acctgaagcg
     7081 gctgggcgtc tgggacgccc gcacccgcga ggcgctacgt gaggcgagcg ggtcggtcca
     7141 gggcttcgcg tggattcccg aggagctgcg ggcgctgtac cgcaccgcct gggagctgcc
     7201 gcagcgcggc ctgatcgaca tggcggcggc ccggaccccg ttcctggacc agagccagtc
     7261 gctcaacctg ttcatggaga cgcccaccat cggcaagctc agctcgatgt acgcgtacgc
     7321 ctggaagaag gggctgaaga ccacgtacta cctgcggtcc cgcccggcca cgcggatcgc
     7381 ccgcgccgcc ggcggctccg cccccgccac cgccaccgtc ccggcgcagg cggcccccga
     7441 cgcggaggcc atcgcctgct ccctggagaa ccccgagtcc tgcgaggcat gccagtaatg
     7501 accacccccg acaccacccc ggcagcgaac gcgcacaccg tcggcgcggc gaagaacctg
     7561 ctcgaccccg gcttcgagct gaccctgcgc ccgatgcggt acccggactt ctacgagcgc
     7621 taccgggacg cgatcaagaa cacctggacc gtcgaggagg tcgacctcca ctccgacgtc
     7681 gccgacctgg cgaagctctc cccgggtgag cagcacctga tcgggcggct ggtcgccttc
     7741 ttcgccacgg gtgactcgat cgtcgccaac aacctcgtgc tgaccctgta caagcacatc
     7801 aactcccccg aggcgcggct ctacctgagc cggcagctct tcgaggaggc cgtgcacgtc
     7861 cagttctatc tgacgctgct cgacacctac ctgcccgacc cggccgaccg cgcggacgcc
     7921 ttcgcggcgg tggagaacat cccctcgatc cgcgagaagg cggagttctg cttccgctgg
     7981 atggactcgg tggacaagct ggaccagctg gagagccagg cggaccgccg caagttcctg
     8041 ctcaacctga tctgcttcgc cgcctgcatc gaggggctct tcttctacgg ggccttcgcc
     8101 tacgtgtact ggttccgctc gcgcgggctg ctgcacgggc tggcgaccgg caccaactgg
     8161 gtcttccgtg acgagacgat gcacatgagc ttcgccttcg acgtggtcga cacggtccgc
     8221 aaggaggagc cggagctgtt cgacgacaag ctccaggagc aggtcgtcgc gatgctcaag
     8281 gaggccgtcg aggccgagct gcagttcgcc cgggacctgt gcggggacgg cctgcccggc
     8341 atgaacaccg agtcgatgcg cgagtacctg gagtgcgtcg ccgaccagcg gctcacccgg
     8401 ctgggcttcg ccccggtgta cggctcgcag aacccgttct ccttcatgga gctgcagggt
     8461 gtgcaggagc tgaccaactt cttcgagcgc cgggtctcgg cctaccaggt cgcggtcgag
     8521 ggcaccgtct ccttcgacga cgacttctga ccggccccgc caacgccgac gcccgccgcc
     8581 cggcccctcg tcctgagggc cgggcggcgg gcgtcggtgc tgggcgcgcg ggcgggtcag
     8641 cggctctcga cccggaagac ggcgcgcttg ggctggaggg tgatcccgat acggggcgcc
     8701 gggtcggtct cggggacggg gacgagccgc cagcggggca gtacggtggc gagcatcagc
     8761 gtggcctcga ccatgctgaa gtggtcgccg gggcatttcc ggttgcccgt gctgaacggc
     8821 atcatcgcgt actgcggtac cttttcggcc cgttcaggaa tccaccggtc cgggtcgaag
     8881 acgtctggcc ggtcgaatga gcgcggatcg tgctgcatcg catacgcgct gtagatgatg
     8941 tccgccccgg ctggaatgcg atagccaccg agttccgtgt ccgcgacggc acggcgagtg
     9001 aatatccacg ccgcaggccg tatccgcatc gattcgacga tgacattgcg ggtgtggtcg
     9061 agggagccca gatcgccgaa attgaccggt cggtccggtg ccacggatag tgcctcctcg
     9121 gccacccgct gttcctcggc cggatgttcg gtgaggagct ggaagcacca ggcgagtgtc
     9181 gaggcgacat tttcggcccc ggcgacgatc agcgagacga gatggtcgtg aatctcctga
     9241 tcgccgagcg gcctgccttc gccgtcctcg gaggtgagca gaatgtcgag caggtcgtcg
     9301 gcgcccttgc cctgcgcgtg ccgctcggcg atcacctcgt cgacgaggtg gtggaggtcg
     9361 gccagcgccc gctcgaagcg ccggttggcg ggggtcggca gccggtgcag cggtccgaag
     9421 gagaggatca tccgccggta caggccgctg aagacggtgt gcagcgaggc gctgatccgg
     9481 tccgccttgg cgccgatcga gtcgacctcc agcagcgagc gggcgaccac ccggaccgcg
     9541 cagctgaacg tctcggcgcc gatgtcgacc acctgcccgt cctgccagcg gtcggccatc
     9601 gcccgcgcct cctcctccat cacggtcgcg tacgaggcga tccgctcggg ccggaaggcg
     9661 ggctgcatca tgcggcgctg gcggcggtgg tcggccccgt tgctggtggc cacccccttg
     9721 ccgagcagca cttcgaggtt ctcccacagc ggcccgccga cctggaactc ctgggagttg
     9781 cgcaacagcg ccccgaccag ctcgggcgcg cagaccgcgt acgccgtctt cgggccgagt
     9841 ttcacgcgga ccaggtcgcc gtggtcgcgc agcccggtga ggaaggccag cgggtcgcgg
     9901 accaggctcg gggcgtggcc gaggacgggc acgctgccgg ccaccagggg cggggtgcgc
     9961 gggcccgggg cggcggggcg ttcggtggtg gattcggcgc tcacgcgtca cctgccagat
    10021 cgctgacgta gggcggggtg ctccggtcgt cccagctgtc gacgcggtaa cggccggact
    10081 cgtggtggaa ccagtagacg gaggagaacc agttccgcat gttgaagacg gccgacccga
    10141 ccgcttcggc gacggaccgg gcctcggcgg tgccggctcc tccggggagt gcggcgagat
    10201 gtccggcgag gagttcccgc aattccttct ccgccacctc gaattcggtg acgcagttct
    10261 ccacgcgttt cctcacctcc accacggcct cttcgagcga cagtccctca tggcgtatga
    10321 gactgattcc cagattgtgc tggtcgtcgc ccgcgagttc tttcgggagt gagcagaggt
    10381 cgttgtacca ggcggagaaa tcctggcagt gccgggccgc cgcgagaaag gggccactcg
    10441 tcctcaggtc cgcgggaatc tcgcgtcccg cggtgggttc gagaaggtcg atccagacgg
    10501 agtggccgaa ggtgtggcgg cgcagttcga tgtattcggc gaccttcggg gtgaccttgg
    10561 tgacccggtt ctcgaattcc tggtcgtagg cgccgacgat ggcgtggaaa tggcgggcga
    10621 accgctcgtt ccaggcgggg ccgaggaagc cgttcagccg gtggacggtc tcggcgaagg
    10681 ccgcgaccag cggctccggg tgggcgaggt ggtcgccggg ggcgtccagc gcggtgtgca
    10741 gttcggcgct gagccggtac caggcggtgc gccgcccgtg gacggcgtcg cggtcgtgct
    10801 ggtcgtccca gacgaagaac caggtgctga agtcggaaat cgccgagatg acatccttcg
    10861 gcgcgcccac gtagtagccg gcgatgaggt cggtgtagcg gagttcgtcc gcatagcggg
    10921 tgaccttgtc ggcgggcatc agccgctttt cgagcagcca ggcgcgggac tccacctgaa
    10981 gctttggcca atactcatga cgatgtcgcg gaaacgcttg ttcgatcacg ggcaacgcca
    11041 gcgcctcggg caccgaagtc gtctgcgccc gtgcggtgct gtgtgggaaa gcaggcacga
    11101 acaaacccct ttcatccgct ttctgccggt gccccctgcc gggcggggca ccgcgcggtg
    11161 gtgtatcccc cgccctttcc attgagcacc acaactgacc agtctggaaa cagatttgct
    11221 ccattcgcca ccccgcgccg acccgaagat cgccatacgt gtccgaaaat tgatcatgtc
    11281 cccacgacac accaccgccc cgcctcccgt acggggagag cggggcggtg cgggtccgcg
    11341 gcggcgggcc ggcgggggcg cctcagtcgt tggggaccgt ctcgtagcgc ggggtgccct
    11401 cggccatctg ccgcagggcg tccttgcgct cgcgcttgga gagccggtcg atgtagaggt
    11461 agccgtacag gtggtccgtc tcgtgctgga ggcagcgggc gaagtagccg gtgccgcgca
    11521 ccacgatcgg gttgcccttc tcgtcctggc cgcggaccac cgcgtagtcg gggcgggcca
    11581 gctccgcgta ggcggtgggg accgagaggc acccctcgtt ggagtcgtcg aggacgcggc
    11641 gctcggaggg cagctcgtcc aggaccgggt tgcagaccac gccgacgtgg cgcgcgccct
    11701 cgtcgtccgg gcagtcgtag acgaagacct tcttgtccac gccgatctgg ttggcggcca
    11761 ggcccacgcc ctccgccgcc cgctggctgg cgaacatgtc gtccaccagc tgggccagct
    11821 ccgcgtcgaa gaccgtcacg tccttcgtct cgcggtgcag caccgggttg cccaccacgg
    11881 tgatcggacg cgcggtgccc cgggcgcggt aggccgcctc acgctcctcg gtgtcctcgg
    11941 tgtcgatgac gaacccctcg tcgtcgaccg gcagcacacc gcccgccacc gcctgctgct
    12001 ccgtgtcctg ctgcgccatg tccgcttccg cgccttcctg ggaacccgtt gtccgtgccc
    12061 gtacagccta cgcgggggcg gcggcgcggg tggccgcgag gacggagcgg ctcagcacac
    12121 ctcttcgagg tcgcgccagg cgcgggtgtc cgggctgtcg gcgacccagc cgtcgagcag
    12181 gccgcgcacc agggcgggcg gggcggcgat gccgcactcg cgctcgggga cccacaggtc
    12241 gccctcgccg gaggtggtcc ggtggcccag cggtccgggc tggcccggtt cgctgtggtc
    12301 gtgcgggtcg acgtgccgct ccccgccgcc ctcgtcgctg ggcatccggc tctccgaaca
    12361 ggtccggcag agcagccgca cggacgagga ccagtcctcg gcggcgaacc cggcgtcggc
    12421 cgccagcagc tccagggcgt cccggtcggc cggggcctgc gcctccagca gcaccaccca
    12481 ggtcggcacc ggggagggcg cccacagctc gatctcgtcg aagaccggat aggtgtcacc
    12541 cgaagcggtg gtccgctcgc cgtgcgggac cccgtcgtgc aggatcacct cgccccagcg
    12601 gcggccggag gagggcagcg ggatcgactg cacctcgatg cgggccgggt ccagccgccg
    12661 gccccagacc acctcggcct ccccctcggg ggagatccgc acggcggcgc tgcccagccc
    12721 catcccggac ggctcaccgg aggccgccgc gtccccgggg atcttcagtc cgtacgcctg
    12781 ccaggcgcgg cgggccagcg gccagtcctg gagggcggtg gcggcgatgc cgacgttcca
    12841 ccagtcgggg gcgccggtgt cccggtccag cagggcgacg gcgcgcaggc ccgcggtacg
    12901 ggcctgttcc cagtcgtggc ggaacttgtg gagcagggcg aggttgaacc aggactcgga
    12961 gagccacggc tccaggtcgg cggcgcgcgt gagcagcgcg cccgcgtcct cgtaccggcc
    13021 gtcgccgatc aaggtgaacg ctcggtcggt cgcctgccgc caggaggcgg aggggcggtg
    13081 ccgtcccttg ccgaagatcc tcacgattcc cgcctgccgg tgtccggtcc cttcgggtcc
    13141 cccgcccgtg cgacggcgct gagcctgggg acggggtacc tcttcgcatc caaccacgga
    13201 cggttggggc gtcgctcatt acccatgggt tacccactgg cgtgaggtgc agaccttctc
    13261 ggaccgggtc gctctatcga gtgacttgcc cagggagcgt ccggcctgta tccgcccgct
    13321 cccgggccgt cccggaggtc agggcgtgtc cgccacttcc gtcgggacga tgtcgtgctg
    13381 cgggaccgcc tggcccgccc ggatcatgtc caggcggctg atcaccttgt cccgcaggtc
    13441 cgcggggacg tcgtcctgac cgcagcaccg cttgaccagc ttcttgacgg cctgctccag
    13501 gccgtacttc tccaggcagg gagagcactc gtcgaagtgc gtgcggatct tgttggagtc
    13561 gctgtcgggc atctcgtggt cgaggaactc gtagagatgg tccaggactt cactgcaatc
    13621 cgtctcgtgc ggctctccgc agctcatgac cccgcgcctt tccgctcgtt cggttccgcc
    13681 gcgctcgccc cggaaccggc ggggaccagc ccgcgctcgc gggcgtagtc ctccagcatg
    13741 ccgcgcagct ggcggcggcc gcggtgcagg cgggacatca ccgtcccgat gggtgtaccc
    13801 atgatgtccg cgatctcctt gtaggcaaac ccctcgacat cggccagata gacggcgatg
    13861 cggaactcct cggggatcgc ctggagggcg gacttcacgt cggagtcggg aaggtggtcc
    13921 agcgcctggg actcggcgga gcgcagaccg gtcgacatgt gcgactcggc acgcgccagc
    13981 tgccagtcct cgatctcctc ggcggcgctg cgctggggct cacgctgctt cttgcggtac
    14041 gagttgatga aggtgttggt gagaatccgg tagagccatg ccttgaggtt ggtgccctca
    14101 cggaactggt ggaacgacgc gtacgccttg gcgtaggtct cctggaccag gtcctcggcg
    14161 tcggccgggt tgcgggtcat ccgcagggcc gccgagtaca tctggtcgag gaaggcgagc
    14221 gcgtcccgct cgaaccgcgc ggtccgctcc gccgaggtct cctcgggctt ctcgggcaca
    14281 tcctggcttc ccgcgtcggt ccccgtgacc ggacccacct ccttcagcgc tgtggcgggc
    14341 ccgccggccg gaccgcccga atcggaggat agaccacgct cctggacttc ccggcgatcc
    14401 cggccggagc cagtgcgcac gggcgcctgc agcaccgacc actccaggtc ggtggcgcgc
    14461 tcgcggctcg ggcagatggt cgaacccatg cggcggactt cctctcgtga tcaacgctgg
    14521 cgaagcacct tcgccccgca caacagccgc cgcccgctcg gcattcccgg ccccccacga
    14581 ggcccgcctc cggccacacg aggcccgctg ccgtccgacg cgaagccccc gaccgacgcg
    14641 aggcccgccc gacccaccgc gacgccgggg gcctccggcc accccatgcc ccgcctcagc
    14701 ccaccggcag ccgctcgatc cacgccccca ccgcgtccgt gatcaccctg agcgcctcct
    14761 cctggccgac cggcgccttc ttcggcacgg cgaacccgtg atcgccgtac gccacctcgg
    14821 ccagctcgta gctccccccg gggaactcct ccggacgccc gaacgggtcc cgcccgccct
    14881 gcaccaccag cgtcggcacc cccgtcccga gcaattcccc ggcccggctc cgctccggct
    14941 tccccggcgg atgcagcgga aagctcagcg cgagcacccc ggcggccccc agctccgccc
    15001 cggtccggca ggccacccgc gcccccgcgc tgcgcccgcc cgccaccacc ggcagcccct
    15061 ccccggccac ctcgccccag accgcctccc accccttgtc cagcgtcttc ggcgccggcg
    15121 ccaccttctt ccccgccacc cgccagggct gctccaccaa ggccacactc accccggccc
    15181 ccggccacac ccccgccaac gccaccagat cccgcgcctc gatccccccc ccggccccgt
    15241 gcccgagcgc cagcacgacg cgcggcacct ccgcccgcac ccaggtgacc cgcgcctccc
    15301 ccacatccgt ggccacgctc acccgctccc ccgccgccgg cacagcggga acacccacac
    15361 cttcagacct cgctacgttc atccggccat cctgccccgc cgaccacacc ccgcccctcc
    15421 ggcaccaccg gcgacgcccc agccagcaca cccccaagcc cgaccggcaa aacccggccc
    15481 gaccggcaaa acccagcccg accggcaaaa cctagcccgg ccggcgtttg aggccacctt
    15541 tcaagcccgg ccggcgtttg aggccatctg tgaccggcac ggtcgccacg cacagcaccc
    15601 ccctgatcag cccggccggc gcttgaggcc cccgcacgct agaacagcgt ccccacctcg
    15661 ggcccgtcca gctcggacac gagcccgggc ccgttgttcc gcacattgct caccgccgtg
    15721 gccacgggat aggcccgcat caacccctca ggcggcgccc ccagcaactc ccgcacctcc
    15781 cccacatccg tcttcgacgg atcaagccag gcgtcccact tgtccggcgt cagcatcaac
    15841 ggcatccggg gatgaatgtc ggccagcgcc cggggcccct ccgcgggccc caccccgagc
    15901 ggcgccgtct ccgcctcggt ggtgaggacg gaacacgtca cccaccaggc ccgcggatgg
    15961 tcccccggca acgagggatc acgccagaac tcgtagagcc cggccatcgc gaagaccgac
    16021 ccgtcggcag gcgtcacgaa gtagggctgc ttacgggccc gcttccgctt cccctcctcc
    16081 tccagcttcc gctcctccgg ggcggtcacc cactcgtaat agccgtcggc ggggaggatg
    16141 cagcgccgcg aggcgaaggc ccggcggtag gcgggcttct cgtggacggt ctcggcccgg
    16201 gcgttgatca tgcgggcgcc gccgtcgggc gaggtggccc aggaggggac gagcccccag
    16261 gtcagcatcc gcaactgccg tacggggcgc gggtcgtcgc tccccttgac cggccggtcg
    16321 aggatggcgg gaacctcctt ggtgggcgcc acgttccagt cggggacgag ggtctcggtg
    16381 ggcacggggg acgcccccgc ctcgtggccg tcctcctggc cttccgccgc ctcgctcagc
    16441 tcggtcttct cgacgccgaa gatctcgctg aggtcctcgg ggctccgggt ggccgcgtac
    16501 cgtccgcaca tacgtgccag actgccaggc cgtgccaccg gaccgccacc agttggggcc
    16561 cggggccgcg cgtcccaccc tcgcgaggag ccgcccgagt atgcagagca ccaccgccgc
    16621 cccggccacc gacctgtggg accgcgtcac cgggacccag accgcccccg agttctggct
    16681 ggtcgtggcg accggcgtgg cggcgctcgc cgtggtcctg tggggcccgg cctggcgcac
    16741 cgcgcggaac gcgatcacca tcgcccacga gggcggccac ggcctgatag ccctggtcac
    16801 cggccgcacc ctggagggga tacgcctcca ctcggacacc tccgggctga ccgtgagccg
    16861 gggcaggccc accggcccgg gcatgatcct caccgccctc gccggttaca ccgccccctc
    16921 cctcctcggc ctcggcggcg cctggctgct ggcctccggg cacatcaccc tgctgctgtg
    16981 ggtggcgacg gccctgctgc tcgccctcct cgtgatggtc cgcaacgcct acggcgtgct
    17041 gacggtgctg atcaccggcg gcctcttcgt ggcggtctcc tggctggccg gctccgaggt
    17101 gcaggccctc ttcgcctacg cggccgtctg gttcctgctg ctgggcgggg tacgcccggt
    17161 cttcgagctc cagtcgaagc ggcggcgcgg cggcgccccg gactccgacg ccgaccagct
    17221 cgcccggctg acccacgccc cggcggccat ctggctcttc ctcttccacg cggtggcgct
    17281 ctgctcgctg atcggcgggg gcggctggct gctcggccgg tgaccgtgca cggggaggag
    17341 cggctgggcg cactaaagtg acggcatgac cctgaacccc gtatccaccc ccctctggcc
    17401 cgccccgtac gcgaccggag ccgtcgaggc gacggtccag gtaccggggt ccaagtcggt
    17461 caccaaccgc gcgctggtgc tggcggccct cgccgccgag ccgggctggc tgcgccggcc
    17521 gctccgctcc cgcgacaccg tgctgatggc ggaggcgctg cgcaccctcg gcgtgggcat
    17581 cgaggagacc gtctcgtccg actcggcggc accgggcagc accctggcca agggcggcga
    17641 ggcgtggcgg atcatcccgt ccggcctgcg cggccccgcc accgtcgacg tcggcaacgc
    17701 gggcaccgtg atgcgcttcc tgccgccgct cgcaaccctc gccgacggcg acatccgctt
    17761 cgacggcgac ccgcgctcct acgagcgtcc gctgcacggc gtgatcgacg cgctgcgcgc
    17821 gctgggcgcc cggatcgacg acgacgaccg gggcagcctg ccgatgacgg tgcacggcac
    17881 gggctccctc gacggcggca cggtggagat cgacgcctcc tcgtcctccc aattcgtcag
    17941 tgccctgctg ctgtcggcgc cccgcttcaa ccagggcgtc gaggtccggc acatcggtcc
    18001 gcggctgccc tcgatgccgc acatccggat gaccgtcgac atgctgcgcc gggtcggcgc
    18061 ccaggtggac gagccggagt cgggcggcga gcccaacgtc tggcgggtca ccccgggcgc
    18121 cctgctcggc cgggacctca ccgtcgagcc ggacctgtcc aacgcccagc ccttcctggc
    18181 ggcggcgctg gtcaccggcg gccgtgtggt cgttccggac tggccggccc acaccacgca
    18241 gccgggtgac cggctgcggg agatcttcac cacgatgggt ggttcctgcg agctgaccga
    18301 ggcgggcctg gtcttcaccg gctcgggccg cgtccacggc atcgacgtgg acctgggcga
    18361 ggtcggcgag ctgaccccgg gcatcgccgc cgtcgcggcc ctggccgacg gcgagtccgt
    18421 cctgcgcggc gtcgcccacc tgcggctcca cgagacggac cggctggccg cgctcaccaa
    18481 ggagatcaac gagctgggcg gcgacgtcac cgagaccgcc gacggcctgc gcatccggcc
    18541 ccgcccgctg cacggcggcg tcttccacac ctacgacgac caccggatgg cgaccgccgg
    18601 tgcgatcctg ggcctggtgg tgaagggcgt cgagatcgag aacgtcgcca ccaccgcgaa
    18661 gaccctgccc gacttccccg acctgtggac cggcatgctc gacgggaccg ggcagtgacg
    18721 gccgggagct gaacgatgcg ccgttacgga aagaaccccg acgaggacga catccgcgtc
    18781 cgccccagcc gccggggcag ccgcccccgc acccacaccc gccccaagca cgaggacgcc
    18841 gccgagggca tggtgctcac ggtggaccgg ggccggatca cctgcctggt cgagggccgc
    18901 acggtgaccg cgatgaaggc ccgcgaactg ggccgcaagg cggcggtggt gggcgaccgg
    18961 gtggcgctgg tcggggatct ctccgggcag aaggacaccc tggcgcgcat cgtgcggatc
    19021 gaggagcgcg cctcggtgct gcgccgcacg gccgacgacg acgacccgta cgagcgggtg
    19081 gtcgtcgcca acgccgaccg gctggcgatc gtcacggcgc tggccgatcc ggagccccgg
    19141 ccccggatga tcgaccgctg cctggtcgcc gcgtacgacg gcggcctgga gccggtcctg
    19201 gtgctgacca agtcggatct ggcctccccc gactccctgc tggacaccta ccgggcgctg
    19261 ggcgtgccgt acgtggtgac cagccgggag gagctggagg acggctcggc cgtggagcgg
    19321 gtccgggagc tgctggacgg ccatgtcacc gccttcgtgg gccattcggg tgtcggaaag
    19381 acgacgctgg tgaacgcgct ggtccccgag gagcagcggc gggtcaccgg ccacgtcaac
    19441 gcggtcaccg gccgcggccg gcacaccacg gtctccgcgc tggcgctgcc gctggccgac
    19501 gccgcccccg gcagctgggt gatcgacacg ccgggggtgc gctcgttcgg gctgcaccac
    19561 gtcgacccct cccgcgtgat ccacgccttc cccgacctgg agccggggac ggaggagtgc
    19621 ccgcgcgggt gcagccacga cgaaccggag tgcgcgctcg accagtgggt ggccgacggc
    19681 cacgccgacc ccgcccgcct caactcgctg cggcggctgc tggcgacccg ggagcggcgc
    19741 gagggcgact gatccgggcg cggcctgcgg cgcgacgggc cgggccgggt cgcctgccgc
    19801 gccggacggc acgggcataa tcgcccgaag ccgtacaagg tgcgcgcggg atcgtttcgg
    19861 cgggcggaaa ggctcattca tggcatggct gctggtcgtc gtcgcggggc tgctggagac
    19921 ggggttcgcc gtctgcctca agctgtcgca cgggttcacc cggctgtggc cgacgatcgc
    19981 cttcgccgcg ttcgccctcg gcagcttcgg cctgctgacc ctcgccctca aacgcctgga
    20041 cgtcggcccg gcctacgcgg tgtggaccgg catcggcgcc gccggcaccg ccacctacgg
    20101 catgatcttc ctcggcgacg tggtctcggt cctgaagatc gtctccatca ccctcgtcat
    20161 ctgcggcgtc atcggcctcc agctctcggg ctcggcccag tgacccgccc gcgccgccgc
    20221 cccgcccccc caccccccac caccggcggc gccacgaccc gggagagggc caggcgcagc
    20281 acgcattcgc actcgcgggc cagttcgcgc gggtcggtcc ggggcgccgc cccgtcgagg
    20341 gcggccacgg cgcggtcgcg ggcggcggcg aggaggtccc cggggccggg gagcgggagt
    20401 tcggcgcggc gctgggcggg cgcggtggcg gtggtgcggg ccgggcgcgg tgcgggcagc
    20461 gggtcgcccc agcagccggt cagcagggag cgcagcaggg tgccggggcg ggcggcggcc
    20521 acggtccagt cggcggcggc gcgcagccgc tcgcgggggt cggccgcgga gcgggccagg
    20581 gcccgttcga tcccggcgag gtagccgtcg gccgcctgcc gggccagggc tcgggcgagc
    20641 ccttccttgc tgccgaactc gttgtagaga gtctgccggg agaccccggc cgaggccgcc
    20701 acctcgccca tccgcaccgc gctccacggg cggcgggcca ggtgggcctc ggcggcgatg
    20761 agcagggctg cgcggacttc cgacacggct gcctccccgg cgagggtcgt gcggggaagt
    20821 cttgcgcggg cgcgggtggt gtcaaggggg tgtgcgcgcg aggtgggggc gccgcgcccg
    20881 ccggtgaccg gatggcccgg cgcggccgga gatcgatact gtttcgccca tggccgacta
    20941 tcacgatgat ctgcgtctcg cccatgtgct tgcgg
//
