LOCUS       NZ_VOGX01000018        11329 bp    DNA     linear   CON 15-OCT-2024
DEFINITION  Streptomyces albidoflavus strain 77 scaffold11_cov50_1_2691061,
            whole genome shotgun sequence.
ACCESSION   NZ_VOGX01000018
VERSION     NZ_VOGX01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Draft Genomic Sequences of Streptomyces misionensis and Streptomyces
            albidoflavus, bacteria applied for phytopathogen biocontrol
  JOURNAL   Microbiol Resour Announc (2019) In press
REFERENCE   2  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Draft Genomic Sequences of Streptomyces misionensis and Streptomyces
            albidoflavus, bacteria applied for phytopathogen biocontrol
  JOURNAL   Microbiol Resour Announc (2019) In press
REFERENCE   3  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2019) Biology, UFLA, Universidade Federal de
            Lavras, Lavras, MG 37200000, Brazil
REFERENCE   4  (bases 1 to 2691061)
  AUTHORS   Pylro,V., Dias,A., Andreote,F., Varani,A., Andreote,C., Bernardo,E.
            and Martins,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2019) Biology, UFLA, Universidade Federal de
            Lavras, Lavras, MG 37200000, Brazil
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-JUL-2019
            Assembly Method                   :: SPAdes v. 3.12
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 36.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007896905.1-RS_2024_10_13
            Annotation Date                   :: 10/13/2024 04:20:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,551
            CDSs (total)                      :: 6,456
            Genes (coding)                    :: 6,343
            CDSs (with protein)               :: 6,343
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 5 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 34 of 113
            Pseudo Genes (incomplete)         :: 81 of 113
            Pseudo Genes (internal stop)      :: 8 of 113
            Pseudo Genes (multiple problems)  :: 8 of 113
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:41:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1142581
            Orig. end                         :: 1153910
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VOGX01000018.1.
            Bacteria and source DNA available from MEB Lab.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11329
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11329
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11329
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6329](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6329
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(203..1099)
                     /gene="sigJ"
                     /locus_tag="FRZ02_RS07330"
                     /old_locus_tag="FRZ02_07330"
     CDS             complement(203..1099)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="sigJ"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951597.1"
                     /locus_tag="FRZ02_RS07330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07330"
                     /product="RNA polymerase sigma factor SigJ"
                     /protein_id="WP_146580430.1"
                     /transl_table=11
                     /translation="MGDGVVGERRQLINVAYRLLGSLAEAEDAVQEAYARWYALPPSRR
                     HEIASPGAWLTTVTGRICLDVLGSSRARRERYVGAWLPDPLPGRAGRPHGTSGDPADQL
                     VLDESVTMAFLVVLETMTPAERVAFVLHDVFRYPFAEVAGVLDRTPAACKQLAASARRR
                     VRTGAPAPAGGQAETVRRVKEAWEAKDIAALVDLLDPAAVMTADGGGLAGAALRPVEGG
                     PHIARYMAGIAVKAPGLELLERPVNGTPGLVARRAGTVLTVAAFDLAADGRVARIWVIR
                     NPEKLRVWAGDGAPSPR"
     gene            1203..1580
                     /locus_tag="FRZ02_RS07335"
                     /old_locus_tag="FRZ02_07335"
     CDS             1203..1580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641248.1"
                     /locus_tag="FRZ02_RS07335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07335"
                     /product="hypothetical protein"
                     /protein_id="WP_010641248.1"
                     /transl_table=11
                     /translation="MTTTQATPRTPVQARFSFLRIALALQTLTVFVQAVSAGLLLSTEY
                     GELLHSAGARVMYGASMLYLLAAVLAWKPGGGSPKAVGYASGFLVLASVQVVSGIAHLS
                     SVHVPLGVLMFGASLVALVRR"
     gene            1743..3107
                     /locus_tag="FRZ02_RS07340"
                     /old_locus_tag="FRZ02_07340"
     CDS             1743..3107
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951595.1"
                     /locus_tag="FRZ02_RS07340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07340"
                     /product="PhoX family protein"
                     /protein_id="WP_129844714.1"
                     /transl_table=11
                     /translation="MSATRRQVLARTGAVAGIAFTGSLSELFAGTAAAKGMGKAGYGPL
                     VPDPKGLLDLPKGFRYRVLSREGDRMLSGEGQVPSNHDGMSAFGGHRGQVHLVRNHENR
                     PTAPIRVPPVRGLTYDPEGMGGCTALTLDPEHRVLGERVAIAGTSTNCAGGPTPWGTWL
                     TCEETEDKAGTNGYTKDHGFIFEVDPVDPHRTGAVPLKAMGRFQHEAIAIDPRHGIVYE
                     TEDAFERPFGLFYRFLPEKPRGGLGSLRAGGALQAMRVPGVPDLSAIQETGASFDRVEW
                     VDVPDPLAEETPIRFQDFGPKGITHAQKLEGCYWGGRSVYFVSSFARSSEGSAADHYGQ
                     IWRYDPDRRRLTLVIVFGPDTDVQLPGEEPDNICLAPSGGLMVAEDGEGAQHVYGVTTR
                     GEVYPMARGRQNIGTPEEPAWGEFAGVCFSPDYDTMFVNCYTPGTTFAVTGPWHR"
     gene            3276..4145
                     /locus_tag="FRZ02_RS07345"
                     /old_locus_tag="FRZ02_07345"
     CDS             3276..4145
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951592.1"
                     /locus_tag="FRZ02_RS07345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07345"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_146581322.1"
                     /transl_table=11
                     /translation="MVRKAKLRTGRALGALMALGAVAGCGQSVPDPHDTAPGPRASHSA
                     SPAAPTAPPTLAPGPGGLAPVFANGPRNDGKTVALTFDADMTADQGERAAGGERFDHPE
                     LIASLRRLKVPATVFMTGRWAEEYPDQARAIGADPLFEIANHSYSHHAFTGDCYGLPRV
                     AESEMRADVERAYTAFRTAGVKKAMPYFRFPGGCYDDAALREVSAAGVTAVQWDVVSGD
                     AFATDADAVAQQVLDGVRPGSVVVMHCTRSAAPTTERALRRIVPALREQGYRFVKVSEL
                     IGAASRKG"
     gene            4176..4889
                     /locus_tag="FRZ02_RS07350"
                     /old_locus_tag="FRZ02_07350"
     CDS             4176..4889
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894649.1"
                     /locus_tag="FRZ02_RS07350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07350"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_146580432.1"
                     /transl_table=11
                     /translation="MTSEPLSDSPFRDERTARDEAPQFVLPLVVRLERAEPPALTDALQ
                     TAARAVLTLLSDPRSEGDGVWAEAVRDWQDARIRKVVRRARGAEWRKAAALPGITLEDG
                     GAEVRVYPPVPLDGWPRELAKLQVSGTELEDPEEPGEPAPGIPVLWLNPDVPMSAGKAM
                     AQAGHGAQLAWWQLSGAERDAWREQGFPLAVRTAGAERWKELVESGLPVVRDAGFTEIA
                     PGSCTVVAEHPALVG"
     gene            5001..6329
                     /locus_tag="FRZ02_RS07355"
                     /old_locus_tag="FRZ02_07355"
     CDS             5001..6329
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641256.1"
                     /locus_tag="FRZ02_RS07355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07355"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_146580434.1"
                     /sec_met_domain="DUF692 (E-value: 9.5e-95, bitscore: 313.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERLGTGIGWRPAIAEAVEAMAGIEWVEVVAENVCPGHLPDSLRR
                     LRERGVAVVPHGVGLGLGGAERPDPVRLAALAERAEALGSPLVTEHIAFVRAGGERTAS
                     RGLEAGHLLPVPRTREGLAVLCENVRIAQDQLPVPLAVENIAALFSWPGEELTEGQFLY
                     ELADRTGVRLLIDVANLHTNHVNQGEDPAAALDALPLEALAYVHVAGGFERDGVWHDSH
                     AHPVPEPVLAVLAELASRVRPPGVLLERDERFPSAAELEAEVAKIRRTVAVAGRDRVPV
                     GAGARPGSAPASGAGVATGPVADEAARTRLALGQTALLSALVAGTPAPEGFDRGRLRVQ
                     SRMLTAKRGSVVASLAPELEQILGDTYRPRFLRYAAGRPLTGGYRGDALAFALHTLREE
                     PPAERAVRRALRDWWIERSGRASLVGRPWARWARVARFALLGR"
     gene            6452..8098
                     /locus_tag="FRZ02_RS07360"
                     /old_locus_tag="FRZ02_07360"
     CDS             6452..8098
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (105-479). E-value:
                     1.4e-20. Score: 65.9. Matches aSDomain:
                     nrpspksdomains_FRZ02_RS07360_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008404759.1"
                     /locus_tag="FRZ02_RS07360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07360"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_146580436.1"
                     /sec_met_domain="PF00561 (E-value: 2.7e-24, bitscore: 83.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPLILTAAGALLLTPLAAPPQAPAAGAPAPPGAPEARGVALAA
                     ERAARTPIAFGPCPDEEGLPRSLECGTVRVPLDYARPDGEQIDLTVSRAKAAGPKNERQ
                     GALVFNPGGPGSSGMLFPLVGIFPEWKRLASVYDLVGYAPRGVGRSAPLSCRDPREKPD
                     GSWQAPEHPTEKQKAGRKAEAEAYARGCAERGGKRLRHIHSLNNARDLDVVRAGLGERK
                     LTFMGASYGSYFGALYAKLFPSHVRRMVFDSAVDPSPSRVWYRNNMAQSAAFEKRWADF
                     RRWIASHDAAYGMGTDEAQVLAGYRRAREKLAAEPAGGTVGPAQLQAVMLRAQYYEDYW
                     PSHAEALAAYLKGDPQPLVNLATPLEEGRVEAENARAVYTAVECNDAPWPTSWQTWDRD
                     HTRLARTAPFETWENAWMNLPCAYWKEPRQTPMDVRVAPGELPPTLILAGERDAATPYA
                     GALELRRRLPDAALVTERGAGTHGLAGGPNACVNRHVEAYLIDGKLPARSTDCAARPAP
                     EPEAQEAGTRAAGSGARPALPRVAGWSPAAR"
     aSDomain        6767..7888
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FRZ02_RS07360_Abhydrolase_1.1"
                     /evalue="1.40E-20"
                     /label="FRZ02_RS07360_Abhydrolase_1.1"
                     /locus_tag="FRZ02_RS07360"
                     /protein_end="479"
                     /protein_start="105"
                     /score="65.9"
                     /tool="antismash"
                     /translation="ALVFNPGGPGSSGMLFPLVGIFPEWKRLASVYDLVGYAPRGVGRS
                     APLSCRDPREKPDGSWQAPEHPTEKQKAGRKAEAEAYARGCAERGGKRLRHIHSLNNAR
                     DLDVVRAGLGERKLTFMGASYGSYFGALYAKLFPSHVRRMVFDSAVDPSPSRVWYRNNM
                     AQSAAFEKRWADFRRWIASHDAAYGMGTDEAQVLAGYRRAREKLAAEPAGGTVGPAQLQ
                     AVMLRAQYYEDYWPSHAEALAAYLKGDPQPLVNLATPLEEGRVEAENARAVYTAVECND
                     APWPTSWQTWDRDHTRLARTAPFETWENAWMNLPCAYWKEPRQTPMDVRVAPGELPPTL
                     ILAGERDAATPYAGALELRRRLPDAALVTERGAG"
     gene            complement(8112..8828)
                     /gene="hemQ"
                     /locus_tag="FRZ02_RS07365"
                     /old_locus_tag="FRZ02_07365"
     CDS             complement(8112..8828)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951588.1"
                     /locus_tag="FRZ02_RS07365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07365"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_003951588.1"
                     /transl_table=11
                     /translation="MSAAPEKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPEDRSGYAD
                     EVQDLFDKLAAKDVTVRGTYDVSGLRADADVMIWWHAETADALQEAYNLFRRTRLGRAL
                     EPVWSNMALHRPAEFNKSHIPAFLADETPRDYISVYPFVRSYEWYLLPDEERRAMLADH
                     GKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARRHVREEVPF
                     YTGRRKSVADLVAQLA"
     gene            complement(8833..10305)
                     /gene="hemG"
                     /locus_tag="FRZ02_RS07370"
                     /old_locus_tag="FRZ02_07370"
     CDS             complement(8833..10305)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008404755.1"
                     /locus_tag="FRZ02_RS07370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FRZ02_07370"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_030773724.1"
                     /sec_met_domain="DAO (E-value: 8e-09, bitscore: 32.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAETEGNPAGAGGASPRVVVVGGGVAGLTAALRLLDAGAGVTLL
                     EASERLGGKLRTGEIGGVRVDLGAESMLARRPEAVGLAREAGLADALQPPATASASLWT
                     RDALRPMPKGHVMGVPADPASLAGVLSEEGVARIAEDRALPRTEVGEDIAVGEYVAARV
                     GREVVDRLVEPLLGGVYAGNAYRISLRAAVPQLFAAAREHTSLTEGVRAIQARTAADPR
                     TDPVFMGIDGGVGRLPLAVADTVRARGGRIRTGTPVTGLARVPGGWRLTTGTPDAPESL
                     EADAVVLAVPAPQAARLLAAELPAASADLAEIEYASMALMTFAFRADEAELPQGSGFLV
                     PPVDGRTVKAATFAGRKWRWIAEQEPGLHVVRTSVGRHREEEILGRDDAGLLALARRDL
                     KAATGVDAEPVDAHVTRWDQGLPQYPVGHLARVARVRDQVAKAPGLALCGAAYDGVGIP
                     ACVASATEAARQVMAARPQGDPASGPSGHAGE"
ORIGIN
        1 gcgccccggg agtcggcgag ggggtggctg ccgacggtca gcgcggggaa tccggcgtcg
       61 gccgccgtcc gggcggacca gacgtcccag acggtcggca gcacgagcgg ctgatggtcg
      121 gcgtgcagct gctgaaggcg ctgagcgcgc tcgacggtgg ttcggaagtc catgccgggg
      181 aagctacccc ggatcgccgc ggtcaacgtg gcgacggggc gccgtccccc gcccagaccc
      241 gcagtttctc cggattgcgg atcacccaga tgcgggcgac gcgtccgtcg gcggcgaggt
      301 cgaaggcggc cacggtcagg acggtgccgg cgcggcgggc gaccaggccg ggggtgccgt
      361 tgaccgggcg ttccaggagt tcgaggccag gggccttcac cgcgatgccg gccatgtacc
      421 gcgcgatgtg ggggccgccc tcgacggggc gcagggcggc gccggccagg ccgccgccgt
      481 cggcggtcat cacggcggcg gggtcgagga ggtcgacgag ggccgcgatg tccttggcct
      541 cccacgcctc cttgacgcgc cgcacggtct cggcctgtcc gccggccggt gcgggggcgc
      601 cggtccgtac ccggcgccgg gcggaggcgg cgagctgctt gcaggcggcg ggagtccggt
      661 cgaggacacc ggcgacctcg gcgaaggggt agcggaagac gtcgtggagg acgaaggcca
      721 cgcgctcggc gggggtcatc gtctccagga cgacgaggaa ggccatggtg acggactcgt
      781 ccaggaccag ctggtcggcg gggtcgccgc tcgtgccgtg cggccgcccg gcccggccgg
      841 gcagcggatc gggcagccac gccccgacgt aacgttcccg ccgtgcccgc gacgagccca
      901 gcacgtccag gcagatccgg ccggtcaccg tggtgagcca ggcgccgggc gaggcgatct
      961 cgtgccggcg cgagggcggc agcgcgtacc agcgggcgta cgcctcctgg acggcgtcct
     1021 cggcctcggc cagcgagccc agcaaccggt aggccacatt gatgagttga cgccgctcgc
     1081 cgacgacccc gtcacccacc cgcgccccct cgccttacct ttccgaggcc cgtgtcgtcg
     1141 ggctggtgag accttattcg acatcggccg ctgccctcgg gcgcggaaaa gggggacccg
     1201 gcatgacgac gacccaggcg acaccccgca cgcccgttca ggcccgcttc tcgttcctgc
     1261 ggatcgcgct cgccctccag accctgacgg tcttcgtcca ggcggtctcg gcggggctgc
     1321 tgctcagcac ggagtacggc gaactcctgc acagcgccgg ggcgcgggtg atgtacgggg
     1381 cgtcgatgct gtacctgctc gccgcggtgc tcgcctggaa gccgggtggc ggctcgccga
     1441 aggcggtcgg gtacgcgtcg ggcttcctcg tactggcctc cgtgcaggtg gtgtcgggga
     1501 tcgcgcacct gtcgtcggtc catgtgccgc tgggggtgct gatgttcggg gcgagtctgg
     1561 tggcgctggt ccggcggtga ggccgggccg tcggccgtac ccggcgtcag gggcgttccc
     1621 agcaggccag gcgggctgtg acggccgtgt ccagggccac gcctggttcc ggtggggctg
     1681 ggtgcgtggt acacacgtgc gggtcacatt cctgtccgca gagccgcagc agggagttgc
     1741 ccatgtccgc gacacgccgt caagtcctcg cccgcaccgg tgccgtcgcc ggtatcgcct
     1801 tcaccggcag tctctccgaa ctcttcgcgg gcacggccgc cgcgaagggg atggggaagg
     1861 ccgggtacgg tccgctggtg cccgacccga agggtctgct ggacctgccg aaaggtttcc
     1921 gctaccgggt gctgtcccgg gagggcgacc ggatgctctc cggcgagggc caggtgccga
     1981 gcaaccacga cgggatgtcc gccttcggcg ggcaccgggg ccaggtccac ctcgtccgca
     2041 accacgagaa ccggcccacc gccccgatcc gcgtcccgcc cgtacgcgga ctgacgtacg
     2101 acccggaggg gatgggcggc tgtacggcgc tcaccctcga ccccgagcac cgggttctcg
     2161 gcgagcgggt cgccatcgcc gggacctcga ccaactgcgc cggcgggccg accccctggg
     2221 gcacctggct gacctgcgag gagaccgagg acaaggccgg gaccaacggc tacaccaagg
     2281 accacggctt catcttcgag gtcgacccgg tcgacccgca ccggaccggc gcggtgccgc
     2341 tgaaggcgat gggccgcttc cagcacgagg ccatcgcgat cgacccgcgc cacgggatcg
     2401 tctacgagac cgaggacgcc ttcgagcggc cgttcgggct cttctaccgc ttcctgcccg
     2461 agaagccgcg cggcggcctc ggctcgctgc gggccggggg cgcgctccag gcgatgcggg
     2521 tgcccggggt gcccgacctc tcggcgatcc aggagacggg tgcctcgttc gaccgggtgg
     2581 agtgggtgga cgtgcccgac ccgctcgccg aggagacgcc gatccgcttc caggacttcg
     2641 gcccgaaggg catcacccac gcgcagaagc tggagggctg ctactggggc ggccgctcgg
     2701 tctacttcgt ctccagcttc gcccggagca gcgagggctc ggccgccgac cactacgggc
     2761 agatctggcg ctacgacccg gaccggcggc gcctcaccct ggtcatcgtc ttcggccccg
     2821 acaccgacgt gcagcttccg ggcgaggagc cggacaacat ctgcctcgcc ccgagcggcg
     2881 gcctcatggt cgccgaggac ggcgagggcg cccagcacgt ctacggcgtg accacgcgcg
     2941 gcgaggtcta cccgatggca cggggccgcc agaacatcgg cacgcccgag gagccggcgt
     3001 ggggtgagtt cgcgggcgtc tgcttctccc cggactacga cacgatgttc gtcaactgct
     3061 acacgcccgg gacgaccttc gcggtcacgg ggccctggca ccggtgacgt gagcgggggt
     3121 gggggcgggt tcccgccccc acccccgcct cgtgggcccg tccggtcgcc cggacggcgg
     3181 agggtggcgg ggcgagacgg gtgaggccgc gcgctccggg cggcgttttg cccgatattc
     3241 agcttttcgc atcctagggt cacggcgtga tcagcatggt gcgcaaggcg aagctccgga
     3301 ccggtagggc gctgggcgcc ctgatggcgt tgggcgcggt ggccgggtgc ggtcagtccg
     3361 ttccggaccc ccatgacacg gcgccggggc cacgggcctc gcactccgcc tcccccgccg
     3421 ccccgacggc gccgcccacg ctggcgcccg gccccggcgg gctcgccccg gtcttcgcca
     3481 acgggccccg gaacgacggc aagaccgtcg cgctcacctt cgacgccgac atgacggccg
     3541 accagggcga gcgcgcggcc ggcggcgagc gcttcgacca cccggagctg atcgcctcgc
     3601 tgcgccgcct gaaggtgccc gccaccgtct tcatgaccgg gcggtgggcc gaggagtacc
     3661 cggaccaggc gcgggccatc ggcgccgacc ctctcttcga gatcgccaac cactcctaca
     3721 gccaccacgc cttcaccggt gactgctacg gcctgccgcg cgtcgccgag agcgagatgc
     3781 gggccgacgt ggaacgggcg tacaccgcgt tccgcacggc cggggtgaag aaggccatgc
     3841 cgtacttccg cttccccggc gggtgttacg acgacgcggc gctgcgggag gtctccgcgg
     3901 ccggggtgac ggccgtgcag tgggacgtgg tgagcgggga cgccttcgcc accgacgccg
     3961 acgcggtggc gcagcaggtg ctggacgggg tccgccccgg ctcggtcgtg gtcatgcact
     4021 gcacccgcag tgccgccccc accaccgagc gcgcgctgcg ccggatcgtg cccgccctgc
     4081 gcgagcaggg gtaccgcttc gtgaaggtgt ccgagctgat cggggcggcc tcgcggaagg
     4141 ggtgagggtc gcccgcggtt tggcagactg gctccgtgac cagcgaacct ctctccgaca
     4201 gtcccttccg tgacgagcgc accgcccgcg acgaggcacc gcagttcgtg ctgccgctcg
     4261 tcgtccggct ggagcgcgcc gagccgcccg ccctcaccga cgcgctccag acggccgccc
     4321 gggccgtcct gacgctgctc agtgatcccc gctccgaggg ggacggcgtg tgggcggagg
     4381 cggtgcggga ctggcaggac gcgcggatcc gcaaggtggt gcggcgggcc cggggcgcgg
     4441 agtggcgcaa ggccgcggcc ctgccgggga tcacgcttga ggacggcggt gccgaggtgc
     4501 gcgtctaccc gccggtgccg ctggacggct ggcccaggga gctggccaag ctccaggtct
     4561 ccggcaccga gctggaggac cccgaggagc cgggcgagcc cgcgcccggc atcccggtgc
     4621 tctggctcaa cccggacgtg cccatgtcgg cggggaaggc gatggcgcag gcgggccacg
     4681 gggcgcagct ggcctggtgg cagctgtcgg gggcggaacg ggacgcctgg cgcgagcagg
     4741 gtttcccgct ggcggtgcgg accgccggcg cggagcgctg gaaggagctg gtggagagcg
     4801 ggctgccggt ggtgcgggac gccgggttca cggagatcgc gcccgggtcg tgcacggtgg
     4861 tggcggagca tcccgcgttg gtggggtgag ggcggcgaag ctcaaatcct gctctgaaga
     4921 gggcgggtga cggttccggg gcggacggcg gcgggcaggg tggccgcagg gaccgggggg
     4981 gtcctggagg gggtggcggt atggaacggc tgggaacggg gatcggctgg cggcccgcga
     5041 tcgcggaggc cgtcgaggcg atggcgggga tcgagtgggt ggaggtggtg gcggagaacg
     5101 tctgccccgg tcacctcccc gactccctgc ggcggttgcg ggagcgtggg gtcgccgtgg
     5161 tgccgcacgg ggtggggctg gggctgggcg gcgcggagcg gcccgatccg gtgcggctgg
     5221 cggcgctggc cgagcgggcg gaggcgctgg ggtcgccgct ggtcaccgag cacatcgcgt
     5281 tcgtccgggc gggcggggag cggaccgcgt cgcgcgggct ggaggccggg cacctgctgc
     5341 cggtcccccg gacccgggaa gggctcgcgg tgctctgcga gaacgtgcgg atcgcccagg
     5401 accagctgcc cgtgccgctc gccgtggaga acatcgcggc gctcttctcc tggccgggcg
     5461 aggagctgac ggaggggcag ttcctctacg agctggccga ccggaccggg gtgcgcctgc
     5521 tgatcgacgt cgccaacctg cataccaacc acgtcaacca gggcgaggac cccgccgccg
     5581 ctctcgacgc gctgccgctg gaggcactgg cgtacgtcca tgtggcgggc gggttcgagc
     5641 gggacggggt gtggcacgac agccacgccc acccggtgcc ggagccggtg ctggcggtcc
     5701 tggccgagct ggcctcgcgg gtgcggccgc ccggggtgct gctggagcgg gacgagcggt
     5761 tcccgtcggc ggccgagctg gaggcggagg tcgcgaagat ccggcggacg gtggcggtgg
     5821 ccggccggga ccgggtcccg gtgggggcgg gggcccggcc cgggtccgcc ccggcgtcgg
     5881 gggccggggt ggcgaccggc ccggtggcgg acgaggcggc gcggacgcgg ctggccctcg
     5941 ggcagacggc gctgctgtcg gctctggtgg cggggacgcc ggcgccggag gggttcgacc
     6001 gggggcggct gcgggtgcag agccggatgc tgaccgccaa gcggggctcc gtggtggcct
     6061 ccctcgcccc ggagctggag cagatcctcg gcgacacgta ccggccgcgc ttcctgcggt
     6121 acgcggcggg ccggccgctg accggcgggt accgcgggga cgcgctcgcc ttcgcgctgc
     6181 acaccttgcg ggaggagccg ccggccgagc gggcggtccg gcgcgccctg cgcgactggt
     6241 ggatcgagcg ctcgggccgc gcctccctgg tgggcaggcc ctgggcccgg tgggccaggg
     6301 tggcacgctt cgccctgctg gggcgctgaa cccggcggcc gtgttgggcc gatccgagcg
     6361 ggtccgtcca acacgcgccc cggtgcttgc ccctgccgac cggcctgcga atcatcccta
     6421 ggactgtcat cggccggacg aaagggacgc gatgcgcgcg ccgctcatcc tcaccgccgc
     6481 cggagcgctg ctcctcaccc cgctcgcggc tcccccgcag gcgcccgcgg ccggggctcc
     6541 ggctccgccc ggcgcccccg aggcgcgcgg ggtggcgctg gcggccgagc gggcggcgcg
     6601 gaccccgatc gccttcgggc cgtgcccgga cgaggagggg ctgccccgct ccctggagtg
     6661 cggcacggta cgggtcccgc tggactacgc gcggccggac ggcgagcaga tcgacctgac
     6721 ggtgagccgg gccaaagcgg cgggcccgaa gaacgagcgg cagggcgcgc tggtcttcaa
     6781 cccgggcggt cccggctcct ccgggatgct cttcccgctg gtggggatct tccccgagtg
     6841 gaagcggctg gcctcggtct acgacctggt cgggtacgcg ccgcgcgggg tcggccggtc
     6901 ggcgccgctc tcctgccggg acccgcgcga gaagccggac gggagctggc aggcccccga
     6961 gcacccgacc gagaagcaga aggccgggcg gaaggccgag gccgaggcgt acgcgcgggg
     7021 gtgcgccgag cgcggcggga agcggctgcg gcacatccac tcgctgaaca acgcccgcga
     7081 cctggacgtg gtgcgggccg gcctcggtga gcggaagctg acgttcatgg gcgcgtcgta
     7141 cggctcgtac ttcggggcgc tgtacgcgaa gctcttcccc tcgcacgtgc gcaggatggt
     7201 cttcgactcg gcggtcgacc cctcgccctc gcgtgtctgg taccggaaca acatggcgca
     7261 gtcggcggcg ttcgagaagc ggtgggcgga cttccggcgg tggatcgcct cgcacgacgc
     7321 ggcgtacggg atgggcaccg acgaggccca ggtgctggcg gggtaccggc gggcgcgcga
     7381 gaagctggcg gccgagcccg ccgggggcac ggtcggcccg gcgcagctcc aggcggtgat
     7441 gttgcgggcc cagtactacg aggactactg gccctcgcac gcggaggcgc tcgcggcgta
     7501 cctgaagggt gatccgcagc cgctggtcaa tctggcgacg ccgctggagg agggccgggt
     7561 ggaggcggag aacgcgcggg ccgtctacac ggcggtggag tgcaacgacg cgccgtggcc
     7621 caccagctgg cagacctggg accgcgacca cacccggctc gcccgcacgg cgccgttcga
     7681 gacctgggag aacgcctgga tgaacctgcc gtgcgcgtac tggaaggagc cccggcagac
     7741 gccgatggac gtgcgggtgg cccccggtga gctgccgccg acgttgatcc tcgccgggga
     7801 acgggacgcg gcgaccccgt acgcgggcgc gctggagctg cggcggcggc tgccggacgc
     7861 cgcgctggtg accgagcggg gcgcgggcac gcacgggctg gcgggcgggc cgaacgcctg
     7921 cgtcaaccgg cacgtggagg cttacctgat cgacgggaag ctccccgcgc gctccaccga
     7981 ctgcgcggcc cggccggccc ccgagccgga ggcgcaggag gccgggacgc gggccgccgg
     8041 gagcggggcg cggccggcgc tcccccgggt cgccgggtgg tccccggcgg cccggtgagg
     8101 cggagcgggg ctcaggcgag ctgggcgacc aggtcggcga cggacttgcg gcgcccggtg
     8161 tagaagggca cctcctcgcg gacgtggcgg cgggcctcgg aggcgcgcag gtggcgcatg
     8221 aggtcgacga tgcggtacag ctcgtcggcc tcgaaggcga ggatccactc gtagtcgccg
     8281 agggagaacg aggcgaccgt gttggcgcgg acgtcggggt agccgcgcgc catcttgccg
     8341 tggtcggcga gcatcgcccg gcgctcctcg tcggggagga ggtaccactc gtaggagcgg
     8401 acgaacgggt agacgctgat gtagtcgcgg ggggtctcgt cggcgaggaa cgccgggatg
     8461 tgcgacttgt tgaactcggc ggggcggtgc agcgccatgt tcgaccagac cggctccagc
     8521 gcgcgcccga ggcgggtgcg gcggaagagg ttgtacgcct cctggagggc gtcggcggtc
     8581 tcggcgtgcc accagatcat cacgtcggcg tcggcgcgca gaccggagac gtcgtaggtg
     8641 ccgcggacgg tgacgtcctt ggcggcgagc ttgtcgaaca ggtcctggac ctcgtcggcg
     8701 tagccggacc ggtcctcggg gagcacgtcg cggagcttga agacggacca cagggtgtag
     8761 cggatgacct cgttgaggtc cttggccttc ttgcccgcgt tggggatctt ctcgggagca
     8821 gcactcatgg ggtcattctc ccgcgtgccc ggacgggccc gacgccgggt cgccctgtgg
     8881 gcgggccgcc atgacctggc gggccgcctc ggtggcggag gcgacgcagg cggggatgcc
     8941 gacaccgtcg taggcggcgc cgcacagggc gaggccgggg gccttggcga cctggtcgcg
     9001 gacgcgggcg acgcgggcga ggtggccgac cgggtactgg ggaagcccct ggtcccagcg
     9061 ggtgacatgg gcgtcgacgg gctcggcgtc gacgccggtg gcggccttga ggtcgcgtcg
     9121 ggcgagggcg aggaggccgg cgtcgtcgcg gccgaggatc tcctcctcgc gatggcgccc
     9181 gaccgaggtg cggacgacgt gcagccccgg ctcctgctcg gcgatccacc gccacttgcg
     9241 tcccgcgaag gtggcggcct tgacggtacg tccgtcgacc ggcggcacga ggaagccgct
     9301 gccctgcggc agctcggcct cgtccgcgcg gaaggcgaag gtcatcaggg ccatcgaggc
     9361 gtactcgatc tcggcgaggt cggcggaggc ggccgggagt tcggcggcga gcagccgggc
     9421 cgcctggggc gcggggacgg cgaggacgac ggcgtcggcc tccagggact cgggcgcgtc
     9481 gggggtgccg gtggtcagcc gccagccgcc ggggacgcgg gcgaggccgg tgacgggcgt
     9541 accggtgcgg atgcggccgc cgcgggcgcg gacggtgtcg gcgacggcga gcgggaggcg
     9601 gccgaccccg ccgtcgatgc ccatgaagac ggggtcggtg cgcgggtcgg cggcggtgcg
     9661 ggcctggatc gcgcggaccc cctcggtcag ggaggtgtgc tcgcgggcgg cggcgaagag
     9721 ctgggggacg gcggcgcgca gcgagatgcg gtaggcgttg ccggcgtata cgccgccgag
     9781 gaggggttcg acgagccggt cgacgacctc gcggccgacc cgggcggcga cgtactcgcc
     9841 gacggcgatg tcctcgccga cctcggtgcg gggcagggcg cggtcctcgg cgatccgcgc
     9901 gacgccctcc tccgagagga ctccggcgag gctggccggg tcggcgggga cgcccatgac
     9961 gtggcccttg ggcatggggc gcagggcgtc gcgggtccac agggaggcgc tggcggtggc
    10021 ggggggctgg agggcgtcgg ccagtcccgc ctcacgggcg aggccgaccg cctcggggcg
    10081 gcgggccagc atcgactcgg cgcccaggtc gacgcggacg ccgccgatct cgccggtgcg
    10141 gagcttgccg ccgagccgct cggaggcttc caggagggtg acgccggccc cggcgtcgag
    10201 caggcgcagc gcggccgtga gccccgcgac gccgcctccg acgaccacca cacgggggct
    10261 cgcgccaccc gctcccgccg ggtttccctc tgtttccgcg cgcatggagc cactgtctca
    10321 aaccggacgc cgcaggcggc cgccggggcg gcgcgcttcc gttaccggtt cgcgacccgg
    10381 gaggcgaaac ccaccggtgc gctgctccgt cgtagcggca caggcgcccc cgaggggtgg
    10441 gcgcggaagg acaagggggg cggcggatga gccggatgcg gggatcgagc ggcggccgga
    10501 tcgcggggcg gcggacggcc gtggtgctgg cggtggcggt actggggctc gcggggtgct
    10561 cggccgggcc ggactccggc gcgtcgtcgg cgggggaccg cgcggtcgcg ccgtcggccg
    10621 ccgacggcgc gggcggcggt caggccgaca gcgcgaagcg ggagtcggcg gacgaggcgt
    10681 cggacgggaa ggcgcgcccc cagctgaagg gcgtccacct ggtccggacg gccgagctgc
    10741 acctgcgggt ggaggacgtg cccgccgcgc tggcctcggc ccgctcggtg gtggagggcg
    10801 cgggcggcta cgtcggcaac gagtcgaccc ggcgcgactc ccaggaccac gagcagtcga
    10861 ccgtggtggt ccgcgtcccg caggagaagt acgacgcggt gctggactcg ctcggcgagg
    10921 gcggcgaggt ggtgtcccgg cggaccagcg cggaggacgt caccgaggag gtggtggacg
    10981 tcgagagccg gctgaagtcg cagcgcgcca gcgtcgcgcg ggtccgggag ctgatggacc
    11041 gggcggagaa gctgagcgac atcgtctcgc tggagggcga gctgagcagc cgccagatgg
    11101 agctggaggc gctgctggcc cagcagtcct cgctgaagga ccgcacctcg atggcgacgg
    11161 tcaccctcca gctgaccgag cggacggcga agacggagtc gcgggaggac gacggcccga
    11221 ccttcaccga cgcgctctcc ggcggctggt cggcgttcgt ggcgacgctg cgctggctga
    11281 ccgtggtggt cggggcggcg ctgccattcg tcctcgccct cggactggc
//
