LOCUS       NZ_CP042266            11302 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces qinzhouensis strain SSL-25 chromosome, complete genome.
ACCESSION   NZ_CP042266
VERSION     NZ_CP042266.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qinzhouensis
  ORGANISM  Streptomyces qinzhouensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8146484)
  AUTHORS   Zhu,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUL-2019) School of Life Science, Hunan University of
            Science and Technology, He Ping Street, Xiangtan, Hunan 411201,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007856155.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 04:30:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,667
            CDSs (total)                      :: 6,577
            Genes (coding)                    :: 6,475
            CDSs (with protein)               :: 6,475
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 28 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 9 of 103
            Pseudo Genes (multiple problems)  :: 20 of 103
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:37:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6226376
            Orig. end                         :: 6237678
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP042266.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jian Gao.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11302
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="23"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11302
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11302
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6302](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6302)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    403..414
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(854..1657)
                     /locus_tag="FQU76_RS27030"
                     /old_locus_tag="FQU76_27030"
     CDS             complement(854..1657)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345819.1"
                     /locus_tag="FQU76_RS27030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27030"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_146482865.1"
                     /transl_table=11
                     /translation="MLRIILLALAWAAAGTACVRLCRAAVATAPHPARRSARRRAHQLT
                     LPEAAFLAGGPGRVMDVTLVAMHRRRALLLAHTGWATVVDPDTDNVLERSVIRAIGPAG
                     HQARTDAVRRAAGSADAVRAIAESLVGAGLAVPDASRARSAAAVRGVRAAALAVPVLTV
                     AALALPGEGAPAGVLLPWFALPLLLTLSALLIGRVEVRPYLGWASPEGRRLLGGLITTA
                     DGTERGRLTAIAVGGPDAIDDPLLRRALTGGRRERADPRTAHRGH"
     gene            complement(1729..2745)
                     /locus_tag="FQU76_RS27035"
                     /old_locus_tag="FQU76_27035"
     CDS             complement(1729..2745)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="FQU76_RS27035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27035"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_186768185.1"
                     /transl_table=11
                     /translation="MTTNTIALYAGLVIAALTLALAAATAAVTLRIPRRRRRTSGRIHN
                     RYEAAFLSAGPGQVADTAIVELHRQQVIEVVAPGIVRVLHNKARGTVPQAVLDLARETD
                     NSALATLRAAAMISPAVQGVGDDLAERGLLTTPSTTRRVVHRWARIQRAALLMCLPAAF
                     VLTFVLAFGFELAGFIPFFFLVVPSAVPGALVAWYCAKRTRGRLTPAGLREFGKYARVR
                     RDPRQGVQVALRGLSEVRNGNVRDLMVLAAALSPSLVAPHFGGDTATASWCGSGNGAGS
                     CGTGGGSACGTGGGSSCGGGGGGGSSCGGGGGGGGSSCGGGGGGSACGGGGGCGGGV"
     gene            complement(2858..3832)
                     /locus_tag="FQU76_RS27045"
                     /old_locus_tag="FQU76_27045"
     CDS             complement(2858..3832)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="FQU76_RS27045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27045"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_146482867.1"
                     /transl_table=11
                     /translation="MDPQVIGIAAMLIVVALVVALAIATNATRPRPRDGKSRGLGIVDT
                     YEAAFLRGGPLRVADAVIAHLHDKKHLAVARPGIVSVLRGGARDTVPKVALDLARDADN
                     SVLSTLRRAVAFSPTVQGMGDRLYEQGLLAPPSAARRAVHRWAMVQLVVLFIAVPASFG
                     LTLFLAVSDDPGAVVFLLPVVVIGAIVTGRCGGLTRGRLTTEGRNTLKAYVRDHRVDGR
                     VAVKVAVRGPRQIPDTTVRELMIAAAAIPLTTHLMYSTTDGSSTASFVPTWCGSADGGG
                     GGDSGCGGGGCGGGSGGGCGGGGGGGGGCGGGGGGGGCGGGGG"
     misc_feature    complement(3816..3831)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            complement(4040..4996)
                     /locus_tag="FQU76_RS27050"
                     /old_locus_tag="FQU76_27050"
     CDS             complement(4040..4996)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="FQU76_RS27050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27050"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_146482868.1"
                     /transl_table=11
                     /translation="MAIGTVAVLVNAVAGVLTVWLIAEAVVSRRRHKQGDGRQVKIDDP
                     YQAAFLSGGPLRAVDAALATMSADGRIRIIEPGIVIVERPEGQDAVERALLTAAGQAPN
                     GALNTLRHTAARSEAVQRIGHGLARSGLLVAMSRDLRVLTRWARVQKILFLLAIPAAAF
                     VTPLVNDGGWTPVGDLFLVRVGPGLLLAAWLSAGVGWNVGDRLTGNGGRALSMHRSEHK
                     DPGTPAERVATMGLGGVQDSTVRAVMIAAATTAFVAVAAGPALAGEQVSWCGGGGSATS
                     CGGSQDDRGGSSCGDGGSCSGGGDGGGCGGCGGCGCG"
     gene            complement(5001..6302)
                     /locus_tag="FQU76_RS27055"
                     /old_locus_tag="FQU76_27055"
     CDS             complement(5001..6302)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890187.1"
                     /locus_tag="FQU76_RS27055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27055"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_146482869.1"
                     /sec_met_domain="DUF692 (E-value: 1.4e-94, bitscore: 314.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHGTLGTGIGWRPEIADTVERLEGVDWVEVVAENVCPGHLPASL
                     ERLRARGTTVVPHGVSLGLGGADRPSGQKLADLAERAEALGAPLVTEHIAFVRAGGPLT
                     ASTRLEAGHLLPVPRTRDALAVLCENVRIAQDALPVPLALENIAALISWPGEEMTEGQF
                     LTELVERTGVRLLIDVANLHTNFVNRGEDPAKCLDELPVEAIAYVHVAGGVERDGVWHD
                     THAHPVPEPVLDVLRELTSRISPPGVLLERDDDFPPEAELAAELESVRTVLRSARPAGR
                     AGDAPAPGPRAVAPAPEDARERLGIAQAALLSALVAGTPAPEEFDQRRLRVQSRALAAK
                     RAQVVAKIAPRLPEILGREYRSTFLAYAKGRPMHAGYRRDAMAFAEYLLAAGEPGDERA
                     RRELTHWWQERAGVRPRRRSARIVRAARAVLVRR"
     misc_feature    complement(6407..6421)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    6408..6422
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.64"
                     /tool="antismash"
     misc_feature    6433..6451
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            complement(6510..7304)
                     /locus_tag="FQU76_RS27060"
                     /old_locus_tag="FQU76_27060"
     CDS             complement(6510..7304)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345814.1"
                     /locus_tag="FQU76_RS27060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27060"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_146482870.1"
                     /transl_table=11
                     /translation="MVRRVNGTVLIIAGIVATVGALLFPVWSYADRSGTGRDQLESSSV
                     PTPWGPLSATDRDFLVRVRLAGLWELPAGQQAVERAPTRAIRAAGDHLVVGHADLDARA
                     RDVAAKLGVELPNQPNEQQQGWLRELSAADGEEYERKFAQLLRNAHGKVFALVAQVRHS
                     TRNTLIRQLATDANQTVLDHITMLEATGRVDFDALAHEAADGATASPTGPPAPDGNAPD
                     GNAPAAPDPAVPTGDLSFTSRPSPRPGPPTAIDTHRPAPPSP"
     gene            complement(7497..8216)
                     /locus_tag="FQU76_RS27065"
                     /old_locus_tag="FQU76_27065"
     CDS             complement(7497..8216)
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345813.1"
                     /locus_tag="FQU76_RS27065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27065"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_186768186.1"
                     /transl_table=11
                     /translation="MSSESLSPDTPFRHESTDRDEAPQFVLPLVARIEKAAPPARTDAL
                     ETAARAVLAILSDDRSHGDGEWARAMRDWQDARIRKVVRRARGAEWRRAGELPGITVTG
                     ATAEVRVYPPVPLDGWPKELVKLQVSGTELDDPGTPTEPDPLRPVLWLNPDVAMSAGKA
                     MAQAGHGAQLAWWELADAERKAWAADGFALAVRTAPRERFAALVAAGLPVVRDAGFTEI
                     PAGSATVVADHPALRAR"
     misc_feature    8348..8362
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.23"
                     /tool="antismash"
     gene            8400..9074
                     /locus_tag="FQU76_RS27070"
                     /old_locus_tag="FQU76_27070"
     CDS             8400..9074
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="FQU76_RS27070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27070"
                     /product="AIM24 family protein"
                     /protein_id="WP_146482872.1"
                     /transl_table=11
                     /translation="MKSDLFSSESLAQPAAAPGMTLQNAKSVKYAVNGEMHARQGSMIA
                     YRGNLQFERKGQGLGGMLKRAVTGEGLALMAVKGQGEAWFAHEAANCFIVDIEQGDALT
                     VNGRNVLCFDATLSYEIKTVKGAGMTGGGLFNSVFSGYGKLAVMCEGVPIVIPVSHQQP
                     VYVDTDAVVGWSASLQTSLHRSQSVGSMIRGGSGEAVQLKLEGEGFVIVRPSELVPQKT
                     GS"
     gene            9219..9428
                     /locus_tag="FQU76_RS27075"
                     /old_locus_tag="FQU76_27075"
     CDS             9219..9428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345811.1"
                     /locus_tag="FQU76_RS27075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27075"
                     /product="hypothetical protein"
                     /protein_id="WP_146482873.1"
                     /transl_table=11
                     /translation="MDASSYCAGRGPADDRPRTAPGPDPGPAGPPYAECVLCREPTEYP
                     ESAKGITLCPVCEWQEAQRTACSG"
     gene            complement(9438..10283)
                     /locus_tag="FQU76_RS27080"
                     /old_locus_tag="FQU76_27080"
     CDS             complement(9438..10283)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310465.1"
                     /locus_tag="FQU76_RS27080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27080"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_146482874.1"
                     /transl_table=11
                     /translation="MIRVRWLAALTMAGAVLVGCAGEQGPPAGPAPARTKAGPPPGTAA
                     PTLAAGPGGAAPVFDRSAVPADRSAKTVALTFDADMTADQGPRAARGEHFDNPALIDTL
                     RTLSVPATVFMTGRWAEEYPEQAKSIGADPLFEVANHSYSHHAFKEPCYGLPALAAPDM
                     KADVDRAFAAFRTAGVRRVVPYFRFPGGCYDETALRALGPAGVTAVQWDVVGGDAFATD
                     PDAVAEQVLKGVRPGSVVVLHCTRSAAPTTEAAIRTIVPELRRRGYRMVKVSELMRAGR
                     "
     misc_feature    10301..10315
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.28"
                     /tool="antismash"
     gene            10424..10978
                     /locus_tag="FQU76_RS27085"
                     /old_locus_tag="FQU76_27085"
     CDS             10424..10978
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310463.1"
                     /locus_tag="FQU76_RS27085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_27085"
                     /product="hypothetical protein"
                     /protein_id="WP_146482875.1"
                     /transl_table=11
                     /translation="MTPPPPTAGVLARPADIGTGSGDRGGAVWRLAESGRQLDANIVRI
                     RPGARVATHVEPDLDVLLCVVGGDGELTTDGGPQPLEPGCVAWLPHGSRRAVTAGPAGL
                     VYLTAHRRRPGLTIRRGPDGSGAAGTDGASGPGEPRTAARAPAEGGEAACPLNRICPGC
                     DRPADDGGARFCSRCGTPLPS"
ORIGIN
        1 ggggaacagc gtggcgtaga gggcgccgaa gtacgtgccg taggaggcgc ccatgaacgt
       61 cagccgctcc tggccgagcg cggcccgcag cacctccaga tcgcgggcgt tgttgaggga
      121 ggtgtagtgg cgcagcgcgt cgcccgcccg ccgcgcgcac gcgtcggcgt actccctggc
      181 ctcggcgatc cgcgcccgct tgaacgcggg cgaggggtgc gtctcggatg ccgtcggggc
      241 cttgacgaac tccttgggct ccaggcacga cagaggtgcc gagcggccga cgccgcgcgg
      301 tgcgtagccg accagatcgt aggcgcgggc gatccgcttc cactcctgga gctgtccggc
      361 gagcgggaag tacatgctgg acgcgcccgg tccgcccggg ttgtagacga acgcgccctg
      421 gtagtcggcg ggttcgccgg tcgccgcgat ccggctgacg gtcagggcga tccgccgccc
      481 gtcgggttcc gcgtagtcga gggggacttc caccgtgccg caggagacgg tttcggggag
      541 gccctccgcc gccgggcagt cgccgaagcg gatgccccgc tcggcggccc ggtccgcggc
      601 ggcggcggta ccccgggcct ccggtgtcgc ggcgtcaccg gacccgtgga ccgcggtgcc
      661 ggtcgcgggc gtcacggtca gcgcggacag gaccagcgac ccgagaccgg ccaccaggcc
      721 gtaccccacc cctctactcg tcacgttccg gttccctttc tgcggacgga cggcagctgc
      781 gcgcgtgcca tgcggtcaag ggatttttcg gggtatgtgt cgagctgtaa agcacctttg
      841 tggggtgtcg cggtcaatgc ccccgatgcg ccgtacgcgg atccgcgcgc tcccggcggc
      901 cgccggtgag cgcccggcgc agcagtggat cgtcgatggc gtcggggccg ccgaccgcga
      961 tcgccgtgag ccgtccccgt tcggtgccgt cggccgtggt gatcagcccg cccagcagtc
     1021 gcctcccttc gggcgaggcc cagcccagat agggccgtac ctcgacccgc ccgatcagca
     1081 gggcggacag ggtgagcagc agcggcagcg cgaaccaggg cagcaggaca ccggccgggg
     1141 cgccctcgcc ggggagggcc agggcggcga ccgtcagcac gggtacggcg agagccgcgg
     1201 cgcggacccc gcgtacggca gccgccgacc gggcccggga ggcgtccggg acggccagcc
     1261 cggcgcccac cagcgattcg gctatggccc ttacggcgtc ggcggatccg gccgcccgcc
     1321 gtaccgcgtc cgtacgggcc tgatggccgg cgggtcctat cgcccggatc accgaacgct
     1381 ccagcacatt gtcggtgtcc gggtcgacga cggtcgccca gccggtgtgt gcgagcagca
     1441 gggcccggcg gcggtgcatg gcgaccaggg tgacgtccat gacccggccg gggccgcccg
     1501 cgaggaaggc ggcttcagga agggtgagtt gatgggcccg ccgccgcgcg gagcggcggg
     1561 ccgggtgcgg ggcggtggcc acggcggcac ggcagagccg cacacaggcg gtgcccgcgg
     1621 cggcccaggc gagggccagc aggatgatcc ggagcattgc cgtgttgtac gtgacgaggg
     1681 ggccggaccg ccaggggttt tccggggcgg tccggccgcc gagcgggttc agacgccccc
     1741 gccgcagccc cctccaccgc cgcacgccga acccccgccg cctccaccgc aggaggagcc
     1801 gccgcccccg ccgccgcctc cgcacgacga tccgccgccc cctccgccgc cgcaggagga
     1861 gccgccgccg gtcccgcagg ccgatccgcc gccggtcccg caggagccgg cgccgttgcc
     1921 actgccgcac caggaggccg tggcggtgtc gccgccgaag tgcggtgcga ccagggacgg
     1981 cgagagggcg gccgcgagca ccatcaggtc ccggacgttc ccgttcctga cctccgagag
     2041 cccccggagc gccacctgga ccccctgccg cgggtcgcgc cgtacccggg cgtactttcc
     2101 gaactcccgc aacccggccg gggtcagcct gccccgggtc ctcttcgcgc agtaccaggc
     2161 gaccagcgca ccgggcacgg ccgatggcac cacgaggaag aagaacggga tgaacccggc
     2221 cagttcgaat ccgaaggcga ggacgaaggt gaggacgaag gcggcgggga ggcacatcaa
     2281 cagggcggcc cgctggatcc gggcccagcg gtgtaccacc cgccgggtgg tggacggcgt
     2341 ggtcagcagg ccgcgttcgg ccagatcgtc gccgaccccc tggaccgcgg gggagatcat
     2401 cgcggccgcc cgcagggtgg ccagagcgct gttgtcggtc tcccgggcca ggtcgaggac
     2461 ggcctggggt acggtgccgc gcgccttgtt gtgcaggacc ctgacgatcc cgggcgccac
     2521 cacctcgatg acctgttgcc ggtgcagttc cacgatggcg gtgtcggcga cctgtccggg
     2581 gccggcgctg aggaaggccg cctcgtaccg attgtggatc cgcccgctcg ttctccggcg
     2641 gcggcgcggt atccgcaggg tgacggcggc cgtcgcggcc gccagggcca gggtgagggc
     2701 ggcgatgacg agaccggcgt acaaggcgat ggtgttggtg gtcacagatg ttctccccct
     2761 tgacggtgag ctgtgcggcc gggcgcggtg gaccgggtcc ggtggtccgg cgcggcggcc
     2821 ccggtgggtg tccccggggc cgccccgcgc ggcccggtca gccgccgccg cccccgcagc
     2881 cgcctcctcc gccaccacca ccacagcctc ctccgccacc gccccctccg ccgcagccgc
     2941 cccccgagcc tccgccgcag ccgccgcctc cacagccgct gtcaccgcct ccgccgccgt
     3001 cggcgcttcc gcaccaggtg ggcacgaacg acgcggtcga ggagccgtcc gtcgtcgaat
     3061 acatcaggtg cgtggtgagc gggatcgccg ccgcggcgat catcagctcc cgcacggtgg
     3121 tgtccgggat ctgccgcggc ccgcgcaccg ccaccttgac cgccacccgc ccgtcgacac
     3181 ggtggtcccg gacatacgcc ttgagcgtgt tgcgcccctc ggtggtgagc cggccccggg
     3241 tcagccctcc gcaccggccg gtgacgatcg cgccgatcac gaccacgggc agcaggaaga
     3301 caacggcgcc cggatcgtcc gagacggcga ggaagagggt gaggccgaag gaggcgggaa
     3361 cggcgatgaa caggaccacg agctggacca tggcccagcg gtgcacggcc cgccgggccg
     3421 cggacggcgg tgccagcaga ccctgctcgt agagccggtc acccatcccc tgcacggtgg
     3481 gggagaaggc cacggccctg cgcagggtgg acaggacgct gttgtcggcg tcccgggcca
     3541 ggtcgagggc gaccttggga acggtgtcgc gggccccgcc gcgcaggacc gagacgatac
     3601 cggggcgtgc gacggccaga tgcttcttgt cgtgcagatg ggcgatgacg gcgtccgcga
     3661 cgcgcagcgg accgccgcgc aggaaggccg cttcgtaggt gtcgacgatc cccagccccc
     3721 gggacttgcc gtcgcggggg cgggggcggg tggcgttggt cgcgatggcc agtgcgacga
     3781 cgagtgcgac gacgatcagc atcgcggcga tgcctatgac ctgtgggtcc atggattgtc
     3841 tccccgttgg tgtggtccgg gccgtgtcgg cggcccggcg ttgagagatg acacaggagc
     3901 aggaaggggc aagaggggat aaaaggggtc gttgggggtg tgtgaggtca accgccggtg
     3961 cggggcagtc cggccgccgg gtccggcccc tgtccccgga taccgtgccg gcggtggccg
     4021 tcgcgcggcg ccggcccggt cagccgcagc cgcagccgcc gcagccgccg caccccccgc
     4081 cgtcgccgcc gccgctgcag gaacccccgt cgccgcagct ggaaccgccg cggtcgtcct
     4141 ggcttccgcc gcaactggtc gcgctgccgc caccgccgca ccacgacacc tgctccccgg
     4201 cgagcgccgg accggcggcg accgcgacga acgcggtggt ggccgcggcg atcatcaccg
     4261 cgcggaccgt gctgtcctgg acgccgccga gtcccatggt ggcgacccgc tccgccgggg
     4321 tgccgggatc cttgtgctcc gaccggtgca tggacagtgc ccggccgccg ttgccggtca
     4381 gccggtcccc gacgttccag cccacgccgg cggacagcca cgcggccagc agcagcccgg
     4441 gcccgacccg taccaggaag agatcgccca ccggtgtcca gccaccgtcg ttgaccaggg
     4501 gggtgacgaa ggccgcggcg ggaatcgcca gcaggaacag gatcttctgg accctggccc
     4561 accgggtgag cacccgcaga tcccggctca tggcgaccag tagcccgctg cgcgccagcc
     4621 cgtggccgat ccgctggacc gcctccgagc gcgccgccgt atgccgcagg gtgttcagcg
     4681 cgccgttcgg cgcctgcccg gccgccgtca gcagggcccg ctccacggcg tcctggccct
     4741 cggggcgctc cacaatgacg atgccgggct cgatgatccg tatccgcccg tcggcgctca
     4801 tcgtggccag cgcggcgtcc acggcccgca gcgggccgcc gctgaggaac gcggcctggt
     4861 acggatcgtc gatcttcacc tgcctgccgt cgccctgctt gtggcggcgg cgggatacga
     4921 cggcttcggc gatcagccag accgtgagca cgccggcgac ggcgttcacg agcacggcga
     4981 cggtaccgat ggccatgcgg tcacctcctg acgagtacgg cccgagccgc acggacgatc
     5041 cgggccgacc ggcgccgggg ccttaccccg gcccgctcct gccaccagtg ggtcagttct
     5101 ctgcgggccc gctcgtcccc gggctccccg gcggccagca gatactccgc gaacgccatc
     5161 gcgtcgcgac ggtagcccgc gtgcatcggg cggcccttgg cgtaggcgag gaacgtactc
     5221 cggtactcgc ggcccaggat ctccggcagc cgcggcgcga tcttggccac cacctgggcc
     5281 cgcttcgccg ccagcgcccg gctctgtacc cgcagcctgc gctggtcgaa ctcctcgggc
     5341 gcgggtgtcc cggcgaccag cgccgacagc agcgccgcct gtgcgatgcc cagccgctcc
     5401 cgcgcgtcct cgggggccgg tgccacggcc cggggcccgg gggccggggc gtcgccggcc
     5461 cgcccggccg gacgcgcgga ccgcagcacc gtacggacgg actccagttc cgccgcgagc
     5521 tcggcctccg gcgggaagtc gtcgtcccgc tccagcagca ccccgggcgg tgagatccgg
     5581 gaggtcagtt cgcgcagtac gtccagtacc ggctcgggca ccggatgggc gtgggtgtcg
     5641 tgccagaccc cgtcgcgctc caccccgccc gcgacatgga cgtacgcgat ggcctcgacc
     5701 ggcagttcgt ccaggcactt cgccggatcc tcgccgcggt tgacgaagtt ggtgtggagg
     5761 ttggcgacgt cgatcagcag gcgtacgccg gtccgctcga ccagctccgt cagaaactgc
     5821 ccctcggtca tctcctcgcc cggccaggag atcagcgccg cgatgttctc cagtgccagc
     5881 ggcaccggaa gcgcgtcctg ggcgatccgg acgttctcgc agaggacggc cagggcgtcc
     5941 cgggtccggg gcacgggcag cagatggccg gcctccagcc gcgttgacgc ggtgagcggg
     6001 ccgcccgccc ggacgaacgc gatgtgctcg gtgacgagcg gggcgccgag ggcctccgcg
     6061 cgctccgcga ggtccgccag cttctgtccg gagggccggt cggcgccgcc gaggccgagg
     6121 gagacaccgt gcgggacgac cgtggtgccc cgggcgcgca gccgctccag agaggcgggc
     6181 agatgtcccg ggcagacgtt ctcggccacc acctcgaccc agtcgacgcc ttcgaggcgc
     6241 tccacggtgt ccgcgatctc gggccgccag ccgatgccgg taccgagtgt gccgtgccgc
     6301 atggtttcct ccccctggtc ccctttgccg tacgtccctt cgggcgtgta cgggggacat
     6361 ggccccgccc ggcgccggtg aaccccgcaa cagggacgtt cagagctgga attgaggttc
     6421 cgctccaccg ggaacgcgac cgaaccgcaa tcctaggtcc tgtcccgggg tgactcgcgg
     6481 ggcccgggag gcggtggggg cggggggagt tacggggacg gcggtgccgg gcgatgggtg
     6541 tcgatcgcgg tcggcggccc ggggcggggc gacggccggg aggtgaagct caggtccccg
     6601 gtcggcaccg ccgggtccgg ggcggccggt gcgttcccgt ccggcgcgtt cccgtccggt
     6661 gcgggcggac cggtcgggct cgccgtcgcc ccgtccgccg cctcgtgcgc gagggcgtcg
     6721 aaatcgaccc ggccggtcgc ctccagcatc gtgatgtggt ccagcacggt ctggttggca
     6781 tcggtcgcca actggcggat gagcgtattc cgggtgctgt gccggacctg ggcgaccagg
     6841 gcgaagacct tgccatgggc attgcgcagc agctgggcga acttgcgctc gtactcctcg
     6901 ccgtcggccg ccgacagctc ccgcagccat ccctgctgct gctcgttggg ctggttcggc
     6961 agctcgaccc ccagcttggc cgccacatcc cgggcccggg cgtccagatc ggcgtggccg
     7021 acgaccagat ggtcaccggc cgccctgatc gcccgggtgg gggcccgctc gacggcctgc
     7081 tgcccggcgg gcagctccca cagtccggcg agccggaccc ggaccaggaa atcgcggtcg
     7141 gtcgccgaca gcggccccca cggggtgggc acgctggagg attcgagttg gtcccggccg
     7201 gtgcccgagc ggtccgcgta ggaccagacc gggaacagca gggcgcccac ggtggcgacg
     7261 atgcccgcga tgatcagaac cgtcccgttg acgcgccgta ccacatctgc ctccccagcc
     7321 ggtgtgcccg tggccggcca accgtcggcg ggagggacgc cgccaccggt tcgctgccgg
     7381 tgagggatac gtaaagcggc atgcgcgtgt tcatcaccgg tccaccacgg atccggtacg
     7441 tgtcccggcg gccggggagt gcggccgggg gagtgcggcg gggtagtgcg gccgggctat
     7501 cgggcccgga gggcggggtg gtccgcgacg accgtcgccg agcctgccgg aatctccgtg
     7561 aagccggcat cccgcaccac cggcagtccc gccgcgacca gggccgcgaa ccgctcgcgc
     7621 ggcgccgtgc ggacggcgag cgcgaacccg tccgccgccc atgccttgcg ctccgcgtcg
     7681 gccagctccc accaggcgag ctgggcgccg tgtccggcct gggccatcgc cttgcccgcc
     7741 gacatcgcca catccgggtt gagccagagc accggccgga gcgggtcggg ctccgtcggg
     7801 gtcccggggt cgtcgagctc ggtgcccgac acctggagct tgaccagctc cttcggccag
     7861 ccgtccaggg gtaccggcgg atagacccgg acctcggccg tcgccccggt caccgtgatg
     7921 ccgggcagct ccccggcccg ccgccactcc gcgccccgcg cccgccgcac caccttgcgg
     7981 atccgggcgt cctgccagtc ccgcatcgcc cgcgcccact cgccgtcgcc gtgggaacgg
     8041 tcgtcggaga ggatcgcgag gaccgcgcgg gcggccgtct ccagtgcgtc cgtacgggcc
     8101 gggggagcgg ccttctcgat ccgggcgacc agcggcagca cgaactgcgg ggcttcgtcg
     8161 cggtcggtgc tctcgtggcg gaagggggtg tcggggctga gggattcgct gctcaccccg
     8221 tccagtctgc cagccggggc cccggccggt gaaaggccgg tgaatggccg gtcagcggcc
     8281 ggtcggcggc cggtggcggg ccccgacagg ccgcccatca ggcccccgcc aggccgatat
     8341 ctcggacacc tgtccgataa tcttggcgga ttgcgcccat ccgggtgagg atgcgccgta
     8401 tgaagagcga ccttttctcc tccgaaagcc tggcccagcc cgcggcggcc ccgggcatga
     8461 cccttcagaa cgccaagtcg gtcaagtacg ccgtcaacgg tgagatgcac gcccgccagg
     8521 gctcgatgat cgcctaccgc ggcaatctcc agttcgagcg caagggccag ggcctcggcg
     8581 gcatgctcaa gcgtgccgtg accggcgagg gtctggcgct gatggcggtc aagggccagg
     8641 gcgaggcctg gttcgcccat gaggcggcga actgtttcat cgtcgatatc gagcagggcg
     8701 acgcgctcac cgtcaacggg cgcaacgtcc tctgtttcga cgccaccctc tcctacgaga
     8761 tcaagaccgt gaagggcgcg ggcatgaccg gcggcggtct cttcaacagc gtcttctccg
     8821 gctacggcaa gctcgccgtc atgtgcgagg gcgttccgat cgtcattccg gtctcccacc
     8881 agcagcccgt ctacgtcgac acggacgcgg tcgtcggctg gagcgcgagc ctccagacct
     8941 ccctgcaccg ctcgcagtcc gtcgggtcga tgatccgcgg cggctccggc gaagccgtcc
     9001 agctcaagct cgaaggcgag ggcttcgtca tcgtccgccc gagcgagctg gtgccgcaga
     9061 agaccggcag ctgacccggc ggcccctacg ggctccgggc ggcgcgcggg ccggtccccg
     9121 gaccggcccc ggcgccgtcg ccccgcccgg cgggggatgc catgacctcg cacccgaccg
     9181 gccccgggcg gagccggtcg cggccgtacc ctggagccat ggatgcctcg tcgtactgcg
     9241 ccggccgcgg gcccgcggac gaccggcccc gaacggcccc cgggccggat cccgggccgg
     9301 ccgggccgcc gtacgccgaa tgcgtactgt gccgtgagcc caccgagtat ccggagtcgg
     9361 cgaagggaat caccctctgc ccggtctgcg agtggcagga ggcccagcgc acggcctgct
     9421 cggggtgacc gcggccgtca gcgcccggcg cgcatcagct ccgacacctt caccatgcgg
     9481 tagccgcgcc gccgcagctc gggcacgatc gtcctgatcg ccgcctccgt cgtcggcgcc
     9541 gcgctgcggg tgcagtgcag caccaccacc gaacccggcc gcaccccctt cagcacctgc
     9601 tcggcgaccg cgtccggatc cgtcgcgaag gcgtcgccgc cgacgacgtc ccactgcacc
     9661 gccgtcacac cggccggtcc gagcgcccgc agcgccgtct cgtcgtaaca gccgccgggg
     9721 aagcggaagt acggcaccac gcgccggaca cccgcggtac ggaacgcggc gaaggcccgg
     9781 tccacatcgg ccttcatatc cggcgcggcc agggcgggca gcccgtaaca gggttccttg
     9841 aaggcatggt ggctgtagga gtggttggcc acctcgaaga gggggtcggc gccgatcgac
     9901 ttcgcctgct ccgggtactc ctccgcccag cggcccgtca tgaagaccgt ggccgggacg
     9961 gagagcgtcc gcagggtgtc gatgagcgcc ggattgtcga aatgttcgcc gcgggcggcc
    10021 cggggaccct gatcggccgt catatccgcg tcgaaggtca gggcgacggt tttcgccgac
    10081 cggtcggcgg gtacggcgga ccggtcgaag accggggccg ccccgccggg ccccgcggcg
    10141 agcgtgggcg ccgccgtgcc cggcggtgga ccggccttcg tccgcgccgg ggccggaccg
    10201 gccggcgggc cctgctctcc ggcacagccc acgagaaccg caccggccat cgtcagggcc
    10261 gccagccaac gcactctgat catcacaaaa ggaacttaag tgatgatcat ggccaggagt
    10321 ggtcgtgttg ccgtggtgtc gggatcccgg tcaggctgtc cacccgagcg ggtgcgcgag
    10381 ccgtgcgtcc gcgccccggt gacacccgta caggaggccc tccatgaccc cgccgccccc
    10441 cacggccgga gttctcgccc gtccggccga tatcggaacc gggtccggtg atcgcggcgg
    10501 cgcggtgtgg cggctcgcgg agtccggccg gcagctggac gccaatatcg tccggatccg
    10561 gcccggcgcc cgggtcgcca cccatgtcga acccgatctg gacgtactgc tctgcgtcgt
    10621 cggcggggac ggcgagctga ccacggacgg cggtccgcag ccgctggagc cggggtgtgt
    10681 ggcctggctc ccgcacggca gccgccgggc cgtgaccgca ggcccggcgg ggctcgtgta
    10741 cctcacggcc caccgccgcc gcccgggcct taccatccgc cggggcccgg acggttccgg
    10801 cgcggcgggt acggacggcg cgagcggccc gggcgagccg cggaccgcgg cgcgggcacc
    10861 ggcggagggc ggtgaggccg cgtgtccgct gaaccggatc tgccccggct gcgaccgccc
    10921 cgccgacgac ggcggcgccc ggttctgttc ccgctgcggc accccgctgc cgtcctgacg
    10981 cccggccgga gggcgtccct ccctccggcc ggacgcgatc acggcccccg cggcgagggt
    11041 cagtcccgcc agggaccggt gacggcgaag gtcgtgcccg ggcggtagca gttgacgtac
    11101 atcgtctcgc cgtccgggga gaacacgaca ccagcgaact cgccccattc gggcaactcc
    11161 ggggtgccga tgttctggcg gttgcgggcc atctcgtaga tttcgccgcg ccgtgacacg
    11221 ccgtacacgt gctgcgcgcc cttgccgtcc tcgcagagca tcagattgcc gccgggggcg
    11281 aggcagatat tgtccgggga ct
//
