LOCUS       NZ_CP042266            10456 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces qinzhouensis strain SSL-25 chromosome, complete genome.
ACCESSION   NZ_CP042266
VERSION     NZ_CP042266.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qinzhouensis
  ORGANISM  Streptomyces qinzhouensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8146484)
  AUTHORS   Zhu,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUL-2019) School of Life Science, Hunan University of
            Science and Technology, He Ping Street, Xiangtan, Hunan 411201,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007856155.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 04:30:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,667
            CDSs (total)                      :: 6,577
            Genes (coding)                    :: 6,475
            CDSs (with protein)               :: 6,475
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 28 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 9 of 103
            Pseudo Genes (multiple problems)  :: 20 of 103
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:37:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5038827
            Orig. end                         :: 5049283
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP042266.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jian Gao.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10456
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="19"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10456
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10456
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5456](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5456
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(807..823)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            complement(1102..1401)
                     /locus_tag="FQU76_RS22055"
                     /old_locus_tag="FQU76_22055"
     CDS             complement(1102..1401)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FQU76_RS22055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FQU76_22055"
                     /product="hypothetical protein"
                     /protein_id="WP_146482068.1"
                     /transl_table=11
                     /translation="MARTSSTSRWQRVPTIPAPHPGTHTYPERAAHQAAPPAGSTPIYE
                     QLVREWAEANRTLPGGPDLEWARTSRFPPPHDPLTGPPPPPLRGGWLHPSTHPA"
     misc_feature    complement(1465..1478)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.57"
                     /tool="antismash"
     gene            1724..2302
                     /locus_tag="FQU76_RS22060"
                     /old_locus_tag="FQU76_22060"
     CDS             1724..2302
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FQU76_RS22060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FQU76_22060"
                     /product="DUF4352 domain-containing protein"
                     /protein_id="WP_146482069.1"
                     /transl_table=11
                     /translation="MMRPTVLPLLLTVCALGAGLTACQGAPAEQSDAKPVNPYPIARPA
                     GGARGAALIGDTVDLGGRASGEHLRLSLTAYVDPAVPVPGKGTAVSRPPEGMRRVGVRV
                     ALLNVGGGPYDASGTETWVADTTGKRHPAVSGGEITTGMPVKWNILAAGESADGWLLFD
                     VPESAVVTQFHGDLGKSAVEWRLRTPPSR"
     gene            2348..2857
                     /locus_tag="FQU76_RS22065"
                     /old_locus_tag="FQU76_22065"
     CDS             2348..2857
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958241.1"
                     /locus_tag="FQU76_RS22065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22065"
                     /product="DUF5949 family protein"
                     /protein_id="WP_146482070.1"
                     /transl_table=11
                     /translation="MTTANPATSAKNSVDRSHLGTLSVLAWTGDPEAGHDMPYLLVYSL
                     GDGEGSAEEGEAALLGMIADCGVKAGEMADVTSTSVNSPIRLLVEAGQAVLNMPYLSAQ
                     CPAPPEWLAAADGRGHVHVIIASRTWPEARPGEPVTEEDLQTYLGDEETLLSSAHVLVR
                     VSQLRS"
     gene            complement(2881..4152)
                     /locus_tag="FQU76_RS22070"
                     /old_locus_tag="FQU76_22070"
     CDS             complement(2881..4152)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346973.1"
                     /locus_tag="FQU76_RS22070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22070"
                     /product="cytochrome P450"
                     /protein_id="WP_146482071.1"
                     /sec_met_domain="p450 (E-value: 1.5e-19, bitscore: 68.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTPAPAPVHPHEPTDRTGPADLADPVFWRLPRADRLAAFAGLRA
                     LDAPVRFGAPEGPGGFYALVRHADVQQASRTPRTFTSAPGVTTPEPAAWVKALFGNSMV
                     NMDDPDHADLRRIVARAFTPRLLAAAEENIRAMAERIVDEMLRDRPADFVAAVASRMPF
                     EIICDLMGVPEVHRREIARRIDEASENVGVGRRGLRMPGRGLRALAHLQRVMGRLARER
                     RRDPADDLISALVTADVDGRALNARELGAFFSLLLVAGVETTRNALAHGLVLLGDHPEQ
                     RELLASDVERYGDGAVEEIVRHSTPIIQFRRTVAAECSLGGRELRPGDKVVLFYASANR
                     DEAVFDSPDVFDITRSPNPHLGYGGGGPHYCLGAHLARQEMKAVFGELLTRTADLRPTG
                     PAQLIDSSFDNRVRALPFAFTARR"
     misc_feature    complement(4329..4349)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.71"
                     /tool="antismash"
     gene            4372..4872
                     /locus_tag="FQU76_RS22075"
                     /old_locus_tag="FQU76_22075"
     CDS             4372..4872
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346972.1"
                     /locus_tag="FQU76_RS22075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22075"
                     /product="hypothetical protein"
                     /protein_id="WP_146482072.1"
                     /transl_table=11
                     /translation="MKSTTRCSVAAVLACMASAVGAGSAAAVSVPVTLPLESLETVLPV
                     PAPELSTGVPVPVPGAPQAPAHVAGRMLPYGTLPRIPLSSELPGTELGVPVTEPLGEST
                     LGVARAGSEAADLSLATPGASLGAPLSAPRPELYGQPEPVLPEVALLTPSLRGAPAAGV
                     LLS"
     gene            5001..5456
                     /locus_tag="FQU76_RS22080"
                     /old_locus_tag="FQU76_22080"
     CDS             5001..5456
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157950.1"
                     /locus_tag="FQU76_RS22080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22080"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_146482073.1"
                     /sec_met_domain="melC (E-value: 5.1e-47, bitscore: 158.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFPDRLGATPTTGPGCSGPGLPRRLALRALFTAAVVGGTAGALA
                     PLLGALRPGRPGAAPTALERFSETYRGRRIEGTATVLVPAHGGGGHPGAPPTVEVRIDG
                     RPLHIMRRADGSFMSLVNHYESFPTLREVARAAVDELGAAQLAVHRG"
     gene            5473..6333
                     /locus_tag="FQU76_RS22085"
                     /old_locus_tag="FQU76_22085"
     CDS             5473..6333
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346970.1"
                     /locus_tag="FQU76_RS22085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22085"
                     /product="tyrosinase family protein"
                     /protein_id="WP_146484513.1"
                     /transl_table=11
                     /translation="MPVRKNQRDLTASEKKRFVDAVLELKRRGEYDEFVRMHGEFYVTD
                     GELRPRAAHMTPSFFPWHRRYLLEFERSLQRIDDRVTVPYWDWTLDASAGSSLWADDFL
                     GGTGRTGDRRVTTGPFAYGNGNWTVNSRVVDGRYLTRDLGRPSDPLTLPTKADVERALA
                     EGAYDAPPWDSTARSGFRNALEGWSAGSPERWRTHNRVHRWVGGLMLGATSPNDPVFWL
                     HHAFVDLLWERWRRAHPGAGYLPAAKLPRGDRQHKRVFALDEPLPPWDVTPAELLDHTR
                     WYRYG"
     gene            complement(6418..6672)
                     /locus_tag="FQU76_RS22090"
                     /old_locus_tag="FQU76_22090"
     CDS             complement(6418..6672)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346969.1"
                     /locus_tag="FQU76_RS22090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22090"
                     /product="chaplin"
                     /protein_id="WP_146482074.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVIAGSGALLAGGAGLAAADAGAHGAAANSPGVISGN
                     VVQVPINIPVNVCGNTIDVIGLLNPAFGNQCVNAGGGAY"
     gene            6837..7082
                     /locus_tag="FQU76_RS22095"
                     /old_locus_tag="FQU76_22095"
     CDS             6837..7082
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958247.1"
                     /locus_tag="FQU76_RS22095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22095"
                     /product="hypothetical protein"
                     /protein_id="WP_146482075.1"
                     /transl_table=11
                     /translation="MTNRGIHRHRKPSRALAVAGLALAAVAAAGAATAAQAAPAEATAT
                     TGGEIDRNLLKPPPGGMLAPVADAATTLFKGGLPGT"
     gene            complement(7521..9137)
                     /locus_tag="FQU76_RS22100"
                     /old_locus_tag="FQU76_22100"
     CDS             complement(7521..9137)
                     /EC_number="3.5.1.-"
                     /GO_function="GO:0047420 - N-acyl-D-amino-acid deacylase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845746.1"
                     /locus_tag="FQU76_RS22100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22100"
                     /product="D-aminoacylase"
                     /protein_id="WP_146482076.1"
                     /transl_table=11
                     /translation="MDLLIRDTRVVDGSGGASYRADVLIREGRIAAIRREGDPAPTAAP
                     GARVLDAAGLALAPGFIDMHAHSDLALLRDPAHEAKAAQGVTLEVLGQDGLSYAPVDDR
                     TLDGVRRSINGWNGGGPGDDSVDFDWRTVGEYLDRLDRGIAVNAAYLVPQGTVRMYAVG
                     WEDRPAGDAELTRMKQLVAEGLEQGAVGMSSGLTYTPGMYAPDTELTELCRVVASYGGY
                     YCPHHRSYGAGALQAYEEMVRLTRDAGCALHLAHATMNFGVNKGKAGELLTLLDEALDA
                     GADISLDTYPYTPGSTTLVATLPSWASEGGPDALLDRLHDDETAERIRHHLEVEGSDGC
                     HGVPMEWETIEISGVSDPALGGYVGKTIEESAKERGEAPWVTARGLMIADRLGSTILQH
                     VGHEENVRTIMRHRVHTGGSDGILQGAKPHPRAYGTFPQYLGRYARELGVLSLEETVAH
                     LTSRPAARLRLPDRGLVREGYRADLVLFDPATVAAGSTFEAPRTLPTGIPYVLIDGRFV
                     IDGGVRTDVLAGRSVRRTPVG"
     gene            complement(9154..10431)
                     /locus_tag="FQU76_RS22105"
                     /old_locus_tag="FQU76_22105"
     CDS             complement(9154..10431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346967.1"
                     /locus_tag="FQU76_RS22105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_22105"
                     /product="amino acid deaminase"
                     /protein_id="WP_146482077.1"
                     /transl_table=11
                     /translation="MPAEPLGQLRHERVDHRFKALPPDADGLTVAELAAERRSLFTGGF
                     TTPVLALSAESVEHNLDLLQTYSERHGLVFAPHGKTSMSPQLFARQLERGAWGITVAVP
                     HQARVCRAHGIQRIFLANEVVDPAALRWLAGELDRDPDFRFVCYADSVRGVELMDRALT
                     DAGARRPVEVVVELGAGDGARTGARTEAECAAVADAIAATTTLKLVGVAGYEGEVPDAD
                     GDRVRAWLRRLVALAGAFDRDGRFADSPDVVISAGGSAWFDAVADVFAEIPALSRPVLK
                     LLRSGAYVSHDDGHYRHLTPFNRVPDEGALQPAFRLWAQVVSRPGPGQAFLNAGKRDAA
                     YDLDLPEAQVVRDARTGEIRPADGIEISGLSDQHGWVRTTPEADLEVGDWVGMGLSHPC
                     TSFDKWQLIPVVEADGTVTDFIRTFF"
ORIGIN
        1 gccgagcacg gcagtccgct gccgatcggg gccttcacgg actacggcct ctggttcgcc
       61 cggcacaccg tgcccgggcc cgacgaacgg accgtcaccc gggtctcggc gggcggtgac
      121 ggattcaccg tcgggaccgt ggacggcgac accgtccggg cccgtaccgt cgtggtcgcg
      181 gtcggggtgc tgccgttcgt ccggatcccg ggaccgctgg cgaaactgcc gcgggagtac
      241 gtcacccaca gcaccggcca ccgtgatctg agcggcttcc gcgaccggga cgtcaccgtc
      301 gtcggcgcgg gccaggcggc cctggagacg gcggtgctcc tcgcggaggg cggcgcccgg
      361 ccggtgctgg tggcccgggc ccacggggtg aactggaaca ccgtgccggt acccgaggac
      421 cggccgctcg tccgccggct gcggaccccg ctcagcggtc tcggctccgg ctggcggagc
      481 tggatctact ccgaactgcc ctgggcggtg cggagactgc ccgacgcccg gcgcgagcac
      541 atcgcccgga ccgcgctggg accggcgggc gcctggtggc tgcgggagcg gtacgagggc
      601 cggatccccg aactgctggc ccaccggatc cgcggcgccc ggctccaccg ggaccggatc
      661 cggctcgccc tggacgctcc ggacggcccg gtcaccgtcg acaccggaca tatcgtggcc
      721 gccaccggct tcaccccgga cctcgaccgg ctcacccttc tcgacgcccg gctccgcacc
      781 cgcctcacca gggtcggcac cggccgcgcc ccggaactga gcgcctcgtt cgaatcgtcg
      841 tgccccgggc tgttcttcgc cggtctgctg agcgcccccg ccttcggccc ttcgatgcgc
      901 ttcgtccacg gcgcgacgta tacggcaccc caggtgaccg ctggcatccg ccgccacctc
      961 cgccccaccc gccgtacccc cctcgtcccc gccccgcacc gcccggcgcc cggcacccgg
     1021 cgggagcgcg tacggaaggg ctgagcgacc gcgtgccccg ccccgcccgc cgcccggggc
     1081 ggggcacccg gtcctcgggt gtcaggccgg atgggtcgaa gggtggagcc agccgccgcg
     1141 caggggcggt ggtggggggc cggtgagggg gtcgtgcggg ggtgggaagc gggacgtgcg
     1201 cgcccactcc aggtcggggc cgccgggcag ggtgcggttg gcctccgccc attcgcggac
     1261 cagctgttcg tagatcgggg tggaaccggc cggtggggcg gcctggtggg cggcccgctc
     1321 cgggtaggtg tgggtacccg ggtgaggggc cgggatggtc gggacgcgct gccatcggga
     1381 agtcgaggat gtccttgcca tacgacagca aacgggggct cacggggcga agtcactgtc
     1441 ggcatgcctg cgcggagtaa cgcaggaacg gtttttcgag gcgtgcggtg tgagccggtg
     1501 cccggtggcc gtgtttccgc gctccggcgc tggaagagcg cgtattcggc cgtacggaga
     1561 gggcgtgcgc gcccggtcta cgggcgctga gcgcacgccg gtcggacccg gctggcgcga
     1621 tggggtgcac ctgggccgac acgaaccctc cggcagggcc gattggcggc attcaggggt
     1681 gaaagggcgt gatcatacgg aaaacggcct tgatgagggg atcatgatgc gacctacggt
     1741 cctgccgctc ctgctgacgg tctgcgcgct cggcgccggt ctgaccgcct gtcagggcgc
     1801 gcccgccgag cagtcggacg ccaaaccggt caacccgtac ccgatcgccc ggcccgccgg
     1861 gggcgccagg ggtgccgcgc tgatcggtga caccgtcgac ctgggcgggc gggcctccgg
     1921 cgagcatctg cggctgtccc tcacggcgta cgtcgacccc gccgtgcccg tcccggggaa
     1981 gggcacggcc gtctcccgcc cgccggaggg catgcgccgg gtcggtgtcc gggtcgcgct
     2041 cctcaatgtc ggcggcggtc cgtacgacgc gagcggtacg gagacctggg tcgccgatac
     2101 gaccggaaaa cgtcatccgg cggtatccgg tggggaaatc accaccggaa tgccagtgaa
     2161 atggaacatc cttgcggcgg gtgaatctgc cgatggctgg ctgctgttcg atgtgccgga
     2221 gtccgccgtg gtcacccaat tccatggtga cctcgggaaa tcggccgtcg agtggcggct
     2281 tcggactccg ccgagcaggt gaattccgag ggtggccggg ggtgccgggg cactagggtg
     2341 ccgaaccatg acgacagcca accctgccac ctccgccaag aattccgtcg accgtagtca
     2401 tttgggcacc ctttccgtac tcgcctggac cggtgacccc gaggccgggc acgatatgcc
     2461 ctatctcctt gtctattccc tcggcgacgg ggaaggcagc gccgaggagg gcgaggccgc
     2521 cctgctcgga atgatcgcgg attgcggggt gaaggcgggt gagatggccg atgtcacatc
     2581 cacttcggtg aattccccga tccggctgct ggtggaggcc ggacaggccg tcctcaacat
     2641 gccttacctc agcgcccagt gccccgcgcc gcccgagtgg ctcgcggccg ccgacggccg
     2701 cggccatgtc catgtgatca tcgccagccg cacctggccc gaggccaggc ccggcgagcc
     2761 ggtcaccgag gaagacctcc agacctacct cggcgacgag gagaccctgt tgtcgtccgc
     2821 gcacgtcctg gtccgcgtct cccagctccg ttcctgacag cacccgcctg ccgttcgctt
     2881 tcaccgccgg gcggtgaagg cgaacggcag ggcccgtacc cggttgtcga aactggagtc
     2941 gatcagttgc gccgggcccg tcggccgcag atccgccgtc cgggtcagca gctcgccgaa
     3001 gaccgccttc atctcctggc gcgccagatg cgcgcccaga cagtagtgcg ggccgccgcc
     3061 cccgtacccc agatgcggat tgggggagcg ggtgatgtcg aagacgtcgg gggagtcgaa
     3121 caccgcctcg tcacggttgg ccgaggcgta gaacagcacc accttgtccc ccggccggag
     3181 ctcgcgcccg ccgagtgagc actccgccgc caccgtccgg cggaactgga tgatcggcgt
     3241 cgagtgccgg acgatctcct ccaccgcgcc gtccccgtac cgctcgacgt ccgaggcgag
     3301 cagctcccgc tgctcggggt ggtcaccgag gagcaccaga ccgtgcgcca gggcgttgcg
     3361 ggtggtctcc accccggcga ccagcagcag cgagaagaag gcccccagct cacgggcgtt
     3421 cagcgcccgg ccgtcgacat ccgccgtgac cagggccgag atcagatcgt cggcggggtc
     3481 acggcggcgc tcccgggcca gccgccccat cacccgctgg agatgcgcca gggcacgcag
     3541 cccccgtccg ggcatccgca gtccgcgccg ccccacgccc acgttctccg aggcctcgtc
     3601 gatacggcgg gcgatctccc gccggtggac ctccgggacg cccatcagat cgcagatgat
     3661 ctcgaacggc atccgggacg ccaccgccgc cacgaagtcc gccggccggt cccggagcat
     3721 ctcgtccacg atccgctcgg ccatcgcgcg gatgttctcc tcggccgccg cgagcagccg
     3781 gggggtgaag gcgcgggcga cgatccgccg cagatcggcg tggtccggat cgtccatgtt
     3841 caccatggag ttgccgaaca gcgccttcac ccaggccgcc ggttcggggg tggtgacccc
     3901 gggggcgctg gtgaaggtac ggggagtccg gctggcctgc tgcacatcgg cgtggcggac
     3961 gagggcgtag aagccgccgg ggccctcggg ggcgccgaag cggacggggg cgtccagggc
     4021 gcgcagcccg gcgaaggccg ccagccggtc cgcgcggggc agccgccaga acaccggatc
     4081 ggcgaggtcg gcgggtcctg tgcgatcggt gggttcgtgc gggtggacgg gggcgggggc
     4141 cggggtgttc atggccggag gtctcctcgg ggtcggatcg gccggacggg ctttcggccc
     4201 gaggccgccc ctatattccc gcccgtctcc ggttgtccgg cgcttcgttc cccggtccgg
     4261 gcccctgccc gctgctgcat tcgggggaac tttgcactgg cccggccgtc cggatcgttc
     4321 tccgggcgca gtcgtcacac cgaacaagaa cgaagagggg catatccacc catgaagtcg
     4381 accacccggt gttctgtcgc ggccgtgctg gcgtgcatgg cgtcggccgt gggggcgggg
     4441 tccgccgccg ccgtgtccgt gccggtcacc cttccgctgg agagcctgga gacggtcctc
     4501 ccggtcccgg cgcccgaact gagcaccggg gtgccggtgc cggtgccggg cgcgccgcag
     4561 gctcccgccc atgtcgccgg gcgcatgctg ccgtacggaa cactgccgcg gatcccgctg
     4621 agcagcgaac tgcccggtac ggagctgggg gtgcccgtca cggagccgct cggcgagagc
     4681 accctcggcg tcgcccgggc cggctccgag gcggcggacc tgtcgctggc caccccgggc
     4741 gcgtcgctgg gcgctccgct gtcggcgccc cggccggagc tgtacgggca gcccgagccg
     4801 gtgctgccgg aggtcgcgct gctcacgccg tcgttgcggg gcgcgcccgc ggcgggcgtg
     4861 ctgctctcct gacggccctc gcggtcctac tggtcgtacc ggccgggcgg ggtggtccac
     4921 ccggaagggg aaccctttcg ccgtcacctc gttgacaggg tccgtacccc tgttccccgt
     4981 agaccgtgaa gggccgcccc atgcgtttcc ccgaccgcct cggcgccacc cccaccaccg
     5041 gccccggctg ttccggcccc gggctgccgc gccggctcgc gctccgcgcc ctcttcacgg
     5101 cggcggtggt cggggggacc gccggggcgc tcgcgccgct gctcggtgcc ttgcgccccg
     5161 gccgccccgg ggccgcgcct accgcgctgg agcggttctc ggagacgtac cgcggccggc
     5221 gtatcgaggg cacggccacg gtgctggtcc cggcgcacgg cgggggcggg cacccgggcg
     5281 cgccgccgac ggtcgaggta cggatcgacg gcagaccgct gcacatcatg cggcgcgccg
     5341 acggcagctt tatgagcctg gtcaaccact acgagtcctt cccgacgctg cgggaggtgg
     5401 cccgggccgc cgtcgacgaa ctgggcgcgg cgcagctggc ggtgcaccgt ggctgacctc
     5461 tcgtgggacc gggtgccggt ccgcaagaac cagcgcgatc tgaccgcgtc ggagaagaag
     5521 cgcttcgtcg acgcggtgct ggagttgaag cgccgcggcg agtacgacga gttcgtccgg
     5581 atgcacggcg agttctatgt cacggacggt gagctgcggc cccgggccgc gcatatgacc
     5641 ccgtcgttct tcccctggca ccgtcgctat ctgctggagt tcgagcggtc gctccagcgg
     5701 atcgacgacc gggtcaccgt cccgtactgg gactggaccc tggacgcctc ggccggttcg
     5761 tccctctggg cggacgattt cctcggcggc accggccgga cgggtgaccg ccgggtgacc
     5821 accgggccct tcgcctacgg gaacgggaac tggaccgtca actcccgggt ggtggacggc
     5881 cgctatctca cccgcgatct gggccgcccg tccgatccgc tgaccctgcc gacgaaggcg
     5941 gacgtcgaac gggcgctcgc ggagggggcg tacgacgcgc cgccctggga ctcgacggcg
     6001 cgcagtggtt tccgcaacgc gctggagggc tggtccgcgg gcagtccgga gcgctggcgc
     6061 acacacaatc gggtgcaccg gtgggtgggt gggctgatgc tgggcgccac ctcacccaac
     6121 gatccggtgt tctggctcca ccatgccttc gtcgacctgc tgtgggagcg gtggcggcgg
     6181 gcgcatccgg gggcgggcta tctgccggcg gcgaagctgc cccggggcga ccgccagcac
     6241 aagcgggtct tcgcgctgga cgagccgctg ccgccgtggg atgtgacgcc cgcggagctg
     6301 ctggaccaca cgcgctggta ccgctacggc tgatgtccgg tgccgggacg gaccgagggc
     6361 cccgcccctc cgacctgcgt cggggagcgg ggccctcggg ctcgggggag ccggggatca
     6421 gtacgcgccg ccgccggcgt tgacgcactg gttgccgaac gccgggttca gcaggccgat
     6481 cacgtcgatc gtgttgccgc agacgttcac ggggatgttg atcggcacct ggacgacgtt
     6541 gccggagatg acgccggggg agttggcggc ggcaccgtgc gctccggcgt cagcggcggc
     6601 caggcccgcg ccaccggcca gcagggcacc ggatccggcg atgacggcgg cggccttcgc
     6661 gatacgcgac atcagtagtt ctccttgcag agtcagcaca tcggccgcag agcttgcggc
     6721 cttcacgttg acaacgcggt accccgtagg tggtaacgga tctttggaga actgattgtc
     6781 tgtgcgagtg gcgccggggc cgtgactccc ggcggggttg gggcgttgcg ccgggcatga
     6841 cgaaccgagg tatccaccga caccgcaagc cgtcccgggc gctcgccgtc gccggactcg
     6901 ccctggccgc cgtggcggcg gcgggcgcgg ccaccgccgc gcaggccgcc cccgcggagg
     6961 cgaccgccac caccggcggc gaaatcgacc gcaacctgct gaagcccccg cccggcggca
     7021 tgctcgcccc ggtcgccgac gccgcgacca ccctcttcaa gggcggcctc ccgggcacgt
     7081 gacccttcca ggggggtgag gggttcgcct ggcccggccc ggaggctttg gggcccctcc
     7141 ccggggtcct ttgggcgggc cggccctcgg gccgagggct tgggggcgct gggggtcccc
     7201 ccacgccgcc aggcgtaggg ggcggaactg cgcgagcgac ccaagccgac cggaagtcgg
     7261 caacgcaccc ccgccgggcc gggcgcgccc cgctttcctg gggcctcggg gggctgccgt
     7321 gccgctgggc accgggactg ccggggccca tgcccccggg cataggggcg cgaggaactg
     7381 cgcgagcgac ccaagccgac cggaagtcgg caacgcaccc ccgccgggcc gggcgccccc
     7441 cggaaccccc aggcccccgg agggatccgc gccggggccc cgacggcggt agggccccgg
     7501 cacggcgctg tgacccggcg tcagccgacc ggcgtacgcc ggaccgaccg gcccgccagg
     7561 acgtccgtac ggaccccgcc gtcgatgacg aagcggccgt cgatcagcac atacgggatc
     7621 cccgtcggca gcgtccgcgg cgcctcgaac gtcgagcccg ccgcgaccgt cgccggatcg
     7681 aagaggacca ggtccgcgcg gtagccctcg cggaccaggc cccggtccgg cagccgcagc
     7741 cgggccgccg ggcgggaggt gaggtgcgcg accgtctcct ccagcgacag gacgccgagc
     7801 tcgcgcgcgt accgccccag gtattggggg aaggtgccgt acgcccgcgg atgcggcttc
     7861 gcgccctgga ggatgccgtc gctgccgccg gtgtggaccc ggtggcgcat gatcgtgcgg
     7921 acgttctcct catggccgac gtgctggagg atcgtggagc cgagccggtc cgcgatcatc
     7981 agcccgcggg cggtgaccca gggcgcctcg ccgcgttcct tcgccgactc ctcgatggtc
     8041 ttgccgacgt atccgccgag cgccgggtcg gagacgccgg agatctcgat ggtctcccac
     8101 tccatcggca ccccgtggca gccgtcggag ccctcgacct ccagatggtg ccggatccgc
     8161 tccgcggtct cgtcgtcgtg cagccggtcc agcagcgcgt ccgggccgcc ctcgctcgcc
     8221 cagctcggca gggtggcgac cagcgtggtg gagccggggg tgtaggggta cgtgtcgagg
     8281 ctgatgtcgg cgcccgcgtc cagcgcctcg tcgaggaggg tcaggagctc gcccgccttg
     8341 cccttgttga cgccgaagtt catcgtggcg tgggcgaggt gcagggcgca gcccgcgtcc
     8401 cgggtgagcc ggaccatctc ctcgtacgcc tggagcgccc cggcgccgta ggagcggtgg
     8461 tgcgggcagt agtagccgcc gtaggaggcg accacccggc acagttcggt cagctcggta
     8521 tcgggcgcgt acatcccggg ggtgtaggtg aggccggagg acataccgac ggcgccctgt
     8581 tccaggccct cggcgacgag ctgcttcatc cgggtcagct cggcgtcgcc ggccgggcgg
     8641 tcctcccagc cgaccgcgta catccggacc gtgccctggg gcacgagata ggcggcgttg
     8701 accgcgatgc cccggtcgag ccggtcgagg tactcgccga ccgtacgcca gtcgaagtcg
     8761 acggagtcgt cgccggggcc gccgccgttc cagccgttga tggagcggcg gacgccgtcg
     8821 agggtgcggt cgtcgacggg ggcgtacgag agcccgtcct ggccgaggac ttcgagggtg
     8881 acgccctggg cggccttggc ctcgtgggcg gggtcgcgca gcagtgccag atcgctgtgg
     8941 gcgtgcatgt cgatgaagcc gggggcgagt gcgagaccgg cggcgtcgag gacgcgggcg
     9001 cccggtgcgg cggtcggggc cgggtcgccc tcgcggcgga tcgcggcgat ccgcccttcg
     9061 cgtatgagga cgtcggcgcg gtaggaggcg ccgccgctgc cgtcgacgac ccgggtgtcg
     9121 cgaatgagga ggtccatcgc tgtgccgcct gtctcagaag aaggtgcgga tgaagtcggt
     9181 gacggtgccg tcggcttcga ccaccgggat caactgccac ttgtcgaacg acgtacaggg
     9241 gtgggagagg cccatgccga cccagtcgcc gacctccaga tcggcctccg gggtggtgcg
     9301 tacccagccg tgctggtcgg agaggccgct gatctcgatg ccgtcggccg ggcggatctc
     9361 gccggtcctg gcgtcccgga cgacctgcgc ctcgggaagg tcgagatcgt acgcggcgtc
     9421 ccgcttgccc gcgttgagga aggcctgccc gggtcccggc cgggagacga cctgcgccca
     9481 gagccggaac gcgggctgga gcgcgccctc gtcggggacc cggttgaagg gggtcagatg
     9541 gcggtagtgg ccgtcgtcgt gggagacgta ggcgccggag cgcagcagct tcagtaccgg
     9601 gcgggagagc gcggggatct cggcgaacac atcggcgacg gcgtcgaacc aggccgagcc
     9661 gcccgcgctg atcaccacat cggggctgtc ggcgaaccgg ccgtcccggt cgaaggcccc
     9721 ggcgagtgcc accaggcggc gcagccaggc gcggacccgg tcgccgtcgg cgtcgggcac
     9781 ctcgccctcg tatccggcga cgcccaccag tttgagcgtg gtggtggcgg cgatcgcgtc
     9841 ggcgacggcg gcgcactcgg cctccgtacg ggctccggtg cgggcgccgt ccccggcgcc
     9901 gagttccacg acgacctcga ccgggcggcg ggccccggca tcggtgaggg cccggtccat
     9961 cagctcgacc ccgcgcaccg agtcggcgta gcagacgaag cggaagtcgg ggtcgcggtc
    10021 cagttccccg gccagccagc gcagcgcggc cgggtcgacg acctcattgg ccaggaagat
    10081 ccgctggatg ccgtgggcgc ggcagacccg ggcctggtgg gggacggcga cggtgatgcc
    10141 ccaggcgccg cgctccagct ggcgggcgaa cagctggggg gacatggagg tcttgccgtg
    10201 cggggcgaag accaggccgt ggcgttcgga gtaggtctgg aggaggtcga gattgtgctc
    10261 gacggactcg gcggagagcg cgagtaccgg cgtggtgaag ccgccggtga agagggagcg
    10321 gcgctcggcc gcgagttcgg ccacggtcag cccgtcggca tccggcggca gcgccttgaa
    10381 gcggtggtcg acgcgctcat ggcggagctg gcccagcggt tcggcgggca tgtgggtcgc
    10441 ctcctcggtc ggtgac
//
