LOCUS       NZ_CP042266            11266 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces qinzhouensis strain SSL-25 chromosome, complete genome.
ACCESSION   NZ_CP042266
VERSION     NZ_CP042266.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qinzhouensis
  ORGANISM  Streptomyces qinzhouensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8146484)
  AUTHORS   Zhu,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUL-2019) School of Life Science, Hunan University of
            Science and Technology, He Ping Street, Xiangtan, Hunan 411201,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007856155.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 04:30:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,667
            CDSs (total)                      :: 6,577
            Genes (coding)                    :: 6,475
            CDSs (with protein)               :: 6,475
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 102
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 28 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 9 of 103
            Pseudo Genes (multiple problems)  :: 20 of 103
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:37:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3996817
            Orig. end                         :: 4008083
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP042266.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jian Gao.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11266
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="16"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11266
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11266
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6266](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6266)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(596..611)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.15"
                     /tool="antismash"
     misc_feature    802..812
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.16"
                     /tool="antismash"
     gene            complement(1232..3898)
                     /locus_tag="FQU76_RS17190"
                     /old_locus_tag="FQU76_17190"
     CDS             complement(1232..3898)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FQU76_RS17190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FQU76_17190"
                     /product="hypothetical protein"
                     /protein_id="WP_146481272.1"
                     /transl_table=11
                     /translation="MDRATTPDRPDGVPAEAVPCEEDGGWTFGATDAEGRTGVWRCWRT
                     DGTLAETSHWHRGRMHGEHFRYHDDGSVALTGQWHEGKRCTLLLHRPDGPSQETVMDQL
                     PESVRSMVQDFDEDGYFIRQRFWTADGSEVDLDGEPIPPRPANVPEDAQHATRHGHWYL
                     QRFAPDGEEPSVGLHRFWETGGALKGVEYHTIDDGLRARLDYRSPLIEAERYGDGRAVE
                     QCLALGLGTSPGAALHAAHEGLTALARRLLSGETGPERAEFTDPRTEPERREAIPDEAV
                     WVAGLKSWVVGEVDGDTGAALGTWRLWLSRPHLDADQVIVAEFRDGRPVSRREYVPWRP
                     EDLDEEWTYDAEGEVLLHRKYERGRRKAETEYLPDGTVAHRRFHRTDRVERVERDEALV
                     SEVWFAEDGTRRAEVAPSGLLVEGEPVEWWRGLDASGAVIAEGPVEQGLKGGPVGRWKL
                     YGVDGADGTERAMVVFDQMDVRRDADLGQFAHGLHLWRTLPVPDVLAGVDDIDWSRYES
                     FFGGSEDFPFLLKGLAVPDEFASGHALGVLWDGVLHQHTVSGIAGPAMRFVIALAESGR
                     GDQSLLELILRVVTRDGSLDATRQLKELHTAAAGAKDPAGYFGENGVESSYHEIYSCLA
                     AATPAWARLAAGTPGTSREDQDARDAREDREAREMAVHLLAAAPGEAAAAALRDLLAAE
                     AARGGARDRESLGDLLLCLGLVPGDATRDLVEPFLTDEDPLLAFCAALTWVRIGATPGP
                     QVLRLLTGALTDLPALDGFGAHWFAEGDASGDALDVLSQLPPEHSRDCLEQMCALLDSA
                     GTFVAPRLARSLLDIVFPTEAYGEGEPLTADQRRVVGALAGTVARWNFVNVDMNEVLRL
                     NGLPCTADELRALCAKE"
     misc_feature    3973..3988
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.43"
                     /tool="antismash"
     misc_feature    complement(3974..3987)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     gene            complement(4004..5008)
                     /locus_tag="FQU76_RS17195"
                     /old_locus_tag="FQU76_17195"
     CDS             complement(4004..5008)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="FQU76_RS17195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_17195"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_146481273.1"
                     /transl_table=11
                     /translation="MAEPLWRPIARTDAPRLAALLAVCEAADRTGAVRGVEDIIEDLDS
                     PGVDPAGGTLSVWSGSEAVACATTRVREHNGLVHQLALDLAVHPAHRTPPLIRRLLDWC
                     RETGVRRHRERYGDAPLELHVRTHHAQVRLAEALDTAGYRRERGYQGMRLELVRENHRL
                     SGAPAVPAGTELVPFDDTFDTALLAARNTIFTDNWGSAPMTARTWRHTITANPCFRPET
                     SFLLLSEPGREILCYLLCTEPGDPAPGRELYLANAGTLPALHGRGLYRAVFAHALVRAR
                     EQSYLRAVLDVDSTNPMAAGGFYERMGFRTFRTWTTHVLARPFPAARTVGGLP"
     gene            complement(5001..6266)
                     /locus_tag="FQU76_RS17200"
                     /old_locus_tag="FQU76_17200"
     CDS             complement(5001..6266)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="FQU76_RS17200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_17200"
                     /product="YcaO-like family protein"
                     /protein_id="WP_186768075.1"
                     /sec_met_domain="YcaO (E-value: 1.3e-47, bitscore: 161.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPAYLAVPRSGERSLSLADAFDRARSAAAALSVEADLEPVLDG
                     SPGTWRCILRRGGESIRTGLGLGKGSRDEARTGALFEALEHYLCGVEGLDPAEIRLAPA
                     HELAEGPLARDIAVRLLGQGPDRPLGCLPYRSLIGGPDADVPLFLSMPEYLRAAGAQAR
                     RAAGDDYDYRAVGRYSVNNGWAAGADPVEAAVHAINELIERDALSLLLIGQFLRERPGR
                     LTVVDPATLPAEPAALVDFAEARAGRRIHLIDMTSDLGVPAYTAYLPAPPGQPARICGW
                     GASLSRRYAITRAVTELVQLHCTMGLREQYAQLLPEQRDDTGPYPRLHACYLSDFTTAL
                     TSAELRAYRDTVAPDTPRGHLDRLIAVLRNHGLAVYQRDHYVTADLAVVNVFVPGLERF
                     MLVTDGQVVVPGERGMAVTGRG"
     misc_feature    6345..6362
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.16"
                     /tool="antismash"
     misc_feature    complement(6359..6373)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.12"
                     /tool="antismash"
     gene            complement(6379..6504)
                     /locus_tag="FQU76_RS35170"
     CDS             complement(6379..6504)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FQU76_RS35170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_281292848.1"
                     /transl_table=11
                     /translation="MGGFQDRDKFHPDEVVLSPAERQTLAELTDKGDVTEPADES"
     gene            6664..7623
                     /locus_tag="FQU76_RS17205"
                     /old_locus_tag="FQU76_17205"
     CDS             6664..7623
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345018.1"
                     /locus_tag="FQU76_RS17205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_17205"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_146481275.1"
                     /transl_table=11
                     /translation="MSAPPPMTATLRDPITETLELTGARCALSCGLTAAGNWALAFPAP
                     GRLKIQAVLQGTIWLVMEGIEHPVRLATGDIAVLAGDRGYILASDPAVPPVDMVPRFRA
                     PTESFTHAGDEGLDAVTIGGHIDLNTTGKDLLLSALPPLMHVGAATAEAPAACWLMDQT
                     LREIRSDAPGAAFAAEHLAQLLLVQVFRTFLTSANADAYPTGWLRALADERIAPALRLI
                     HGDPAHPWTLTELARAAAMSRTTFAQRFKETAGVPPLTYLCAWRMRLARHTLRREDTSV
                     SSIAASLGYRSESAFSNAFKRTTGLSPRRYRDAARTGD"
     gene            complement(7658..8545)
                     /locus_tag="FQU76_RS17210"
                     /old_locus_tag="FQU76_17210"
     CDS             complement(7658..8545)
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006347889.1"
                     /locus_tag="FQU76_RS17210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_17210"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_146481276.1"
                     /transl_table=11
                     /translation="MSAVAPAAAPVTVIGLGPMGAAMAEALLAEGHEVTVWNRTPARAE
                     PLVAKGARLAESVAAALGANELVILSLTDYDAMDALLKPVAGALAGRTVVNLSSDTPER
                     TREGARWVTAAGAEFLAGGVTTPPSGIGDPENTYTFYSGPRDAFDRRRSTLEVLTRADY
                     QGEDPGRAALMYQIGMTMFWTSMLSYWQAIALADAHGLKAADVLSHARETFASLDMFTS
                     FYAERVDADHHEGDVDRLSMGTASVEHVLHTMRDAGVDPTLPQAVVDLFRRGMAAGHGN
                     DSFSSLLGLVKAAK"
     gene            8843..9361
                     /locus_tag="FQU76_RS17215"
                     /old_locus_tag="FQU76_17215"
     CDS             8843..9361
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018556798.1"
                     /locus_tag="FQU76_RS17215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_17215"
                     /product="toxin-antitoxin system HicB family antitoxin"
                     /protein_id="WP_146481277.1"
                     /transl_table=11
                     /translation="MDLTPYVDTVRRELAAASGAGGEDARELAERLNAPLEAATRLAML
                     NVLSAAMDEVTRELAPGSVDVRLRGLDPDFVVTLPPLDGVASMKPVPPAEPFRSPAPAE
                     GDEGATARVNLRLPAHLKARVEEAAGREGLSLNAWVVRAVSATVDGGPGSRPPETAQSI
                     GDSITGWVR"
     gene            9436..10278
                     /locus_tag="FQU76_RS17220"
                     /old_locus_tag="FQU76_17220"
     CDS             9436..10278
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604312.1"
                     /locus_tag="FQU76_RS17220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FQU76_17220"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_146481278.1"
                     /transl_table=11
                     /translation="MPSYDTPEPISVTAHVEGGSIRFTASERLDTVVGVQPREPKKELD
                     ARTAEQTEVSYANGLLTVRTPKPNLFGRTGIVDVTVELPTGSRIDMTGAWAQVFGEGRL
                     GQVRVKTSSGDVRLDTTGPLNLIASHGSISVDRVEGMAELTTSSGSLRVGLLDGPAVLK
                     NSHGTTVVGAATGELRVKGANGDIEIRRAEDSVTAVTAHGTVRVGEVARGTIQLETSYG
                     AIDVGVREGTAAWLDVSSRSGQVRNTLTESESPAGTDDTVKIRARTRHGSIDILRAKP"
     misc_feature    complement(10470..10484)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    10543..10557
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     misc_feature    10916..10930
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.13"
                     /tool="antismash"
ORIGIN
        1 atcggcttcg acccccgggg cgtcggtcgc agcacccccc tgacctgcga agttccctcg
       61 gagcagcgga aggaggcccg gccgtaccgg agcgcgacct tccagcgtga tgtggccgag
      121 acccgggccg tcgccgagaa gtgccgggcg aagtacgggg actccatccg gcacttcaac
      181 acccggaaca ccgcccgcga catggacgcg atccgcgccg cgctgggcga acagaagatc
      241 aactacctgg ggtactcgta cggcacctat ctgggcgcgg tctactccga actcttcccg
      301 caccgcagcg accgcatggt gctggacagc gccgtcgacc cggacctcgt atggcagaag
      361 gacacccatc tgtacgccac ggaggtcgag cgggccttta cccgctggac gaagtgggcg
      421 gcgcggaacg cggaccgcta ccacctcggc aacaccccgg cccgggtgtc ccggaccttc
      481 tggaagatcg tcgagcaggc ggaccgtaag ccggtcctgg tcggtgagca ccgctacgac
      541 ggcacagagc tccgctccgc gatgcggccg tacttctact cgcgggaagc ggcgtccgag
      601 ctgacggtca atctgcggaa ggcggcggcg ggcgagccgg tgccgccctt cgaaggggcg
      661 ggccggatat cggatgacaa cacccactcc tccttcaacg ccgtcacctg cggtgacgcc
      721 gcctggtccc ggagcgtcaa gggctaccgc gcctcggccg aacggaacgc ggcccgctac
      781 cccctcttcg gtgaccacgc cttcaatgtg acgccctgca ccttctggga caagccggtg
      841 gagaagccca cccgggtgcg gaacgacgtc cgcgcgctga tcctccagaa cgagtgggac
      901 tcacagaccc cgctcatcgg cgcccgggga ctgcggtccc atatgaaggg ttcgcgtctg
      961 gtgaccgtcg acgaggggga gggccacggt atctacgcgg cgaaccggaa cggctgtgtg
     1021 gacgatctga cgacggccta tctggcccat ggcacctacc cgtcgaagga cgtcacctgc
     1081 cgcgccgagc cgcccgcgcc gcaggaggga ccggcgaacc cggtccaccc ggcgatcgcg
     1141 gacgcggcgc ggggcaacct ccgctgaccg cgccgggccc cgtgcccgcc ccggaccatg
     1201 acggatccgg gcgggcgcgg gcccccgggc ttcactcctt cgcgcagagg gcgcgcagct
     1261 catcggcggt gcacggcagc ccgttgaggc ggagcacctc gttcatatcg acgttgacga
     1321 agttccagcg ggcaacggtg ccggcgagcg ccccgaccac cctccgctgg tccgccgtga
     1381 gcggctcgcc ctcgccgtac gcctcggtcg ggaacacgat gtcgagcagg gagcgggcca
     1441 gccggggggc gacgaaggtg ccggccgagt ccaggagggc gcacatctgc tccagacagt
     1501 cccgggagtg ctcgggcggg agctgggaca ggacgtcgag cgcatcgccg gacgcatcgc
     1561 cctcggcgaa ccagtgcgcg ccgaaaccgt ccagtgcggg caggtcggtc agggcgccgg
     1621 tgaggagccg cagcacctga ggtccggggg tggcgccgat ccgtacccag gtgagcgcgg
     1681 cacagaaggc gagcagcgga tcctcgtcgg tgaggaacgg ctccaccaga tcgcgtgtcg
     1741 cgtcaccggg caccaggccc agacagagca gcagatcacc tagggactcc cggtcccgcg
     1801 caccgccccg cgccgcctcg gcggccagca gatcccgcag ggcggccgcg gcggcctcgc
     1861 ccggggcggc ggccagcaga tggacagcca tctcccgcgc ctcccggtcc tcccgcgcgt
     1921 ctcgcgcgtc ctggtcctcc cgggaagtgc cgggcgtccc ggcggcgagc cgggcccagg
     1981 ccggggtcgc ggcggcgaga cagctgtaga tctcgtggta cgaggactcc acgccgttct
     2041 ccccgaagta ccccgccgga tccttcgcgc cggcggccgc ggtgtgcagc tccttgagct
     2101 gccgggtggc gtccaggctg ccgtcgcggg tgacgacgcg caggatcagc tccagcaggc
     2161 tctgatcgcc ccgcccggac tcggccagcg cgatcacgaa ccgcatcgcc ggaccggcga
     2221 tcccggagac ggtgtgctgg tgcagcaccc cgtcccagag cacccccagg gcatgtcccg
     2281 aggcgaactc gtccggcacg gcgagcccct tgagcaggaa ggggaagtcc tcactgccgc
     2341 cgaagaagct ctcgtaccgg ctccagtcga tgtcgtccac gcccgccagg acgtccggca
     2401 ccggcagggt ccgccagagg tgcaggccat gggcgaactg ccccaggtcg gcatcgcgcc
     2461 gtacatccat ctgatcgaaa acgaccatcg cgcgctcggt gccgtccgcg ccgtccacgc
     2521 cgtacagctt ccaccgcccc acggggccgc ccttgaggcc ctgctcgacc gggccctcgg
     2581 cgatcaccgc gccggaggcg tccagaccgc gccaccattc gaccggctcc ccctccacca
     2641 ggaggccgga gggcgcgacc tcggcccgcc gggtcccgtc ctcggcgaac cacacctcgg
     2701 acaccagggc ctcgtcccgt tcgacgcgtt cgacgcggtc ggtccggtgg aaacggcggt
     2761 gggcgaccgt gccgtccggc agatactccg tctcggcctt ccgccgcccc cgttcgtact
     2821 tccggtggag cagtacttcg ccttcggcgt cgtaggtcca ctcctcgtcc aggtcctcgg
     2881 ggcgccacgg cacgtactcg cggcggctga ccgggcggcc gtcgcggaac tcggccacga
     2941 tcacctggtc ggcgtcgagg tgcggtctgc tcagccacag ccgccaggtg ccgagggcgg
     3001 cgccggtgtc cccgtcgacc tcgccgacga cccaggactt caggcccgcg acccagaccg
     3061 cctcgtccgg tatcgcctcc cgccgctccg gctcggtgcg cggatcggtg aactccgccc
     3121 gctccgggcc cgtttcaccg ctcagcagcc gccgggccag cgccgtaaga ccctcgtggg
     3181 ccgcgtgcag cgcggcgccc ggcgaggtgc cgagcccgag ggccagacac tgctcgaccg
     3241 cccgtccgtc cccgtaccgc tccgcctcga tcagcggact gcggtagtcg agccgggcgc
     3301 ggagcccgtc gtcgatggtg tggtactcca cgcccttcag cgctccgccg gtctcccaga
     3361 accggtgcag ccccacgctc ggttcctccc cgtccggtgc gaagcgctgg aggtaccagt
     3421 ggccgtgccg ggtcgcgtgc tgggcatctt ccgggacgtt cgccgggcgc gggggtatcg
     3481 gctcgccgtc gagatcgacc tccgagccgt cggcggtcca gaaccgctgg cggatgaaat
     3541 acccgtcctc gtcgaagtcc tggaccatgc tccggacgga ctccgggagc tggtccatga
     3601 cggtctcctg ggacggaccg tccgggcggt ggaggagcag cgtgcaccgc ttgccctcgt
     3661 gccactgccc ggtcagcgcg accgaaccgt cgtcgtggta ccggaagtgc tcgccgtgca
     3721 tccggccccg gtgccagtgg ctggtttcgg ccagggtccc gtcggtccgc cagcagcgcc
     3781 acaccccggt tcttccctcg gcgtccgtcg ccccgaaagt ccaccctccg tcctcctcac
     3841 agggcacggc ctcggcggga acgccgtccg ggcggtcggg ggtggtggct ctgtccatgg
     3901 tcatgctcct cgtccctgcc tgtcacggag cgcggtcggc cgcgcgagtg aaccgcaccg
     3961 aactgccccc cgtggaccgt gtgttcggtg ctgcgacggg atattagggg aggcctccga
     4021 cagtgcgggc ggccgggaag ggccgagcca gtacatgggt ggtccaggtg cggaacgtcc
     4081 ggaaccccat gcgctcgtag aagcccccgg ccgccatcgg gttcgtcgag tcgacgtcca
     4141 gcacggcccg caggtagctc tgctccctcg cccggacgag ggcatgcgcg aagacggccc
     4201 ggtacaggcc ccggccgtgc agagcgggca gcgtaccggc gttggcgaga tagagctcgc
     4261 ggccgggcgc cgggtccccc ggctcggtgc agagcagata gcagaggatc tcccggccgg
     4321 gctccgagag gagcaggaac gaggtctcgg gccggaagca ggggttcgcg gtgatcgtat
     4381 ggcgccaggt ccgggccgtc atcggggcgc tgccccagtt gtcggtgaag atggtgttac
     4441 gggccgcgag cagcgccgtg tcgaacgtgt cgtcgaaggg cacgagctcg gtgcctgccg
     4501 gtaccgccgg cgcaccggag agccggtggt tctcccgaac cagctccagc cgcatgccct
     4561 ggtagccgcg ctcgcgccgg tacccggcgg tgtccagcgc ctccgcgagc cggacctggg
     4621 cgtggtgggt gcggacatga agctccagcg gagcgtctcc gtaccgctca cggtggcgcc
     4681 ggacaccggt ctcccggcac cagtccagca gccgccggat caggggcggg gtgcggtgcg
     4741 cgggatgtac cgcgaggtcc agcgccaact ggtgtacgag accgttgtgt tcccggaccc
     4801 gggtggtcgc acaggccacc gcctcgctgc cggaccagac ggagagggtg ccgccggccg
     4861 gatcgacccc cggggagtcc aggtcctcga tgatgtcttc cacgccccgg acggcaccgg
     4921 tccggtcggc cgcctcgcag acggcgagca gcgccgccag ccggggcgcg tcggtgcggg
     4981 cgatcgggcg ccacagcggt tcagccacgg ccggtgaccg ccatgccgcg ctcaccgggc
     5041 acgacgacct gcccgtcggt gaccagcatg aaccgctcga gtcccggcac gaacacattg
     5101 accacggcga ggtccgcggt gacgtagtgg tcccgctggt agacggccag accatggttc
     5161 cgcaggacgg cgatgagccg gtcgagatgg ccccggggcg tgtccggggc caccgtgtcc
     5221 cgataggccc tgagctcggc cgaagtcagc gctgtggtga agtccgacag atagcaggcg
     5281 tgcagcctcg gatacgggcc ggtgtcgtcg cgctgctcgg gcagcagctg cgcgtactgc
     5341 tcgcgcaaac ccatggtgca gtggagctgt acgagttcgg tcacggcgcg tgtgatggcg
     5401 taccggcggg acagtgaggc accccagccg cagatccggg ccggctgccc cggcggggcg
     5461 ggcagatagg ccgtgtacgc gggcacaccg aggtcgctgg tcatatcgat cagatggatc
     5521 cggcggcccg cccgcgcctc cgcgaagtcg accagggcgg ccggctcggc cggcagggtc
     5581 gccgggtcca cgacggtcag ccgcccgggc cgttcgcgga ggaactggcc gatcagcagc
     5641 agggagagcg cgtcccgctc gatcagctcg ttgatcgcgt ggacggcggc ttccaccggg
     5701 tcggcgcccg cggcccagcc gttgttgacc gagtagcggc cgaccgcacg gtagtcgtag
     5761 tcgtcaccgg cggcccgccg ggcctgtgct ccggccgccc gtagatattc gggcatggac
     5821 aggaagaggg gaacgtccgc gtccggtccg ccgatgagcg agcggtacgg caggcacccc
     5881 agcggccggt ccgggccctg gcccaggagc cgtacggcga tgtcccgggc cagcgggccc
     5941 tcggcgagct catgggcggg tgcgagccgg atctccgccg ggtccagccc ctccaccccg
     6001 cagaggtagt gctccagcgc ctcgaacagg gcgccggtcc tggcttcgtc ccggctgcct
     6061 ttgcccaggc cgaggccggt acggatggac tcgccgccac ggcgcaggat gcaccgccag
     6121 gtgccggggc tgccgtcgag taccggctcc agatcggcct ccaccgacag agcggcggca
     6181 gcggaccgcg cccggtcgaa ggcgtcggcc agggagagac tgcgctctcc cgaccggggg
     6241 actgcgagat acgcggggat ggtcacgccc ggtcccgtct gctcggcggc cgcgggccgc
     6301 ggcggatcga cacccgccgc ggcccgcggc ccgtgaatct ccggctgtta tccggctgtt
     6361 ctctggttgt gaaccgggtc agctctcgtc ggccggctcg gtcacatcgc ccttgtcggt
     6421 gagctcggcg agggtctgcc gctcggcggg cgacagcact acctcgtccg ggtggaactt
     6481 gtcgcggtcc tggaatccgc ccatgagtac aacctcctga gagtgaggaa gcggccgccc
     6541 ggccgacggc cgcgatccgg ggcccggacc ccgttcgggg aagcgcccca ccactcatgg
     6601 tgatgagggg ccgacggaat gtgaatgctt gcccgtccgt gcgtcttgcg ccagagtccg
     6661 cctatgtccg caccgccccc catgactgcg accctgcggg accccatcac cgaaaccctc
     6721 gaactcaccg gcgcccgttg cgccttgtcc tgcggtctca ccgccgcggg caactgggct
     6781 ctggcctttc cggcgccggg ccggctcaag atccaggccg tgctccaggg caccatctgg
     6841 ctggtgatgg agggcatcga gcaccccgtc cgcctggcga ccggcgatat cgcggtcctc
     6901 gccggagacc gcggctacat cctggccagc gacccggccg tacccccggt cgacatggtc
     6961 ccccggttcc gggcgcccac cgagtccttc acccacgccg gggacgaagg gctggacgcc
     7021 gtcaccatcg gcggccatat cgacctcaac accaccggca aggacctgct gctgagcgcc
     7081 cttccgccgc tgatgcacgt cggcgccgcc acggccgagg cgcccgcggc ctgctggctc
     7141 atggaccaga ccctgcgcga aatacggtcg gatgccccgg gggccgcctt cgcggcggag
     7201 cacctcgcgc agctgctcct tgtgcaggtc ttccgcacct tcctgaccag cgcgaacgcc
     7261 gatgcctacc cgacggggtg gctgcgcgcc ctcgccgacg aacgcatcgc ccccgccctg
     7321 cgcctgatcc acggcgaccc ggcccacccc tggaccctga ccgaactggc ccgcgccgcg
     7381 gccatgtccc gcaccacctt cgcccagcgc ttcaaggaga ccgcgggcgt cccgccgctg
     7441 acgtacctct gcgcctggcg gatgcgcctg gcccgccaca ccctccggcg cgaggacacc
     7501 tccgtctcgt ccatcgccgc gtccctgggc taccggtccg agagcgcctt cagcaacgcc
     7561 ttcaaacgca cgacgggcct ctccccacgc cgctaccgcg acgccgcccg caccggagac
     7621 taagaccggt gcggtccgcg gcgggcccgc ccccgcgtca cttcgccgcc ttcaccagcc
     7681 ccagcaggct ggagaagctg tcgttcccgt ggcccgccgc catgccccgg cggaagaggt
     7741 ccaccaccgc ctgcggcagg gtcgggtcca cgcccgcgtc cctcatcgtg tgcaggacgt
     7801 gctccacgct cgccgtaccc atcgacaggc ggtccacatc gccctcgtgg tggtccgcgt
     7861 cgacgcgctc ggcgtagaag gaggtgaaca tgtccagcga ggcgaaggtc tcccgggcgt
     7921 gggagaggac gtcggccgcc ttgaggccgt gcgcgtcggc gagggcgatc gcctgccagt
     7981 agctcagcat cgacgtccag aacatggtca tgccgatctg gtacatcagg gccgcgcgcc
     8041 ccgggtcctc gccctggtag tcggcccggg tcagcacctc cagggtggac cgccggcggt
     8101 cgaaggcgtc ccgcgggccg ctgtagaagg tgtacgtgtt ctccgggtcg ccgatcccgg
     8161 acggcggtgt ggtgactccg ccggccagga actccgcacc cgcggcggtg acccagcggg
     8221 cgccctcgcg ggtccgctcg ggggtgtccg agctgagatt gacgacggta cgtccggcca
     8281 gcgcgcccgc caccggtttc agcagcgcgt ccatcgcgtc gtagtcggtc aggctcagga
     8341 tcaccagctc attcgccccg agcgcggccg ccacgctctc cgcgagccgc gcgcccttgg
     8401 cgacgagtgg ttcggcccgg gcgggggtcc ggttccagac ggtgacctcg tggccctcgg
     8461 cgaggagcgc ttcggccatg gcggctccca tgggcccgag gccgatgacg gtgacgggcg
     8521 cggcggcagg ggcgacggcg gacatgggac tcctctatca gttctaaaac gagcgctcta
     8581 tttagagctt gccgggactg tagcacgcga ctggagcgag cgctctagcg aaggtgcggc
     8641 catctggtgg cgcgaggtgg cgccaagtgg tgctgtgtgg tgccaacccg tgcgtgtgcg
     8701 ggtagtggcg ctcttgtggc gcactcgtcg aaggtccccc gccttcgcgt ttccgcagct
     8761 cagggccgtc cgtcgccatc gcggtccaga tagggcgcca tatggcttgc gaatggcgcc
     8821 acatcggtgc catgatgacg tcatggacct cacaccgtat gtcgacaccg tccgccgcga
     8881 gctcgcggcg gcctccgggg ccggcgggga agacgcccgt gagctggcgg agcggctgaa
     8941 cgccccgctg gaggcggcga cccgcctggc catgctgaac gtgctctccg ccgccatgga
     9001 cgaggtcacc cgggagctcg cccccggctc ggtggatgta cggctgcgcg gtctcgatcc
     9061 cgacttcgtg gtgacgctgc cgcctctcga cggcgtcgcc tccatgaagc cggttccgcc
     9121 cgccgaaccg ttcaggtccc cggcgcccgc cgaaggtgac gagggcgcca ccgcccgcgt
     9181 caatctgcgg ctgccggccc acctcaaggc ccgcgtcgag gaggccgcgg gacgcgaggg
     9241 cctgtcgctc aacgcctggg tggtgcgggc ggtgtcggcc acggtcgacg gcggccccgg
     9301 gtcccgcccg ccggagacgg cccagagcat cggagacagc atcaccggct gggtccgcta
     9361 gctcggtcca ccagtccacc ttcactacgt cccggcaaag gggacgccgc acagacccac
     9421 aaggacggga cagccatgcc ttcttacgac acccctgagc cgatctcggt gaccgcgcat
     9481 gtggaaggcg gttccatccg gttcaccgcg agcgagcgcc tcgacaccgt cgtcggcgta
     9541 cagccccgtg agccgaagaa ggagctggac gcgcggaccg cggagcagac cgaggtctcc
     9601 tacgcgaacg gcctgctgac cgtccggacc cccaagccca atctgttcgg ccgtaccggc
     9661 atcgtcgatg tgacggtcga actgcccacg ggctcccgga tcgatatgac cggcgcctgg
     9721 gcccaggtgt tcggcgaggg ccggctcggc caggtccggg tgaagacctc gtccggcgat
     9781 gtgcggctgg acacgaccgg cccgctgaac ctgatcgcct cgcacgggtc gatcagcgtc
     9841 gaccgggtcg agggcatggc cgagctgacc accagctccg gcagcctgcg cgtcggtctc
     9901 ctcgacggtc cggccgtcct gaagaactcg cacggcacca cggtcgtcgg cgccgcgacc
     9961 ggcgagctgc gggtgaaggg cgccaacggc gatatcgaga tccggcgcgc cgaggactcg
    10021 gtcaccgccg tcaccgccca cggcaccgtc cgggtcggtg aagtggcccg cggcaccatc
    10081 cagctggaga cctcctacgg cgccatcgac gtcggtgtcc gggagggcac ggccgcctgg
    10141 ctggacgtca gctcccgttc cggccaggtc cgtaacaccc tcaccgagtc cgagtccccg
    10201 gccgggaccg acgacaccgt caagatccgt gcccgtaccc ggcacggcag catcgacatc
    10261 ctccgcgcca agccctgacc cccgaaaaag aaccgaaatc ccccgtagac ccccgtagac
    10321 ccccgacgca cctttccttc gatcaggagt gccccatgcc ctcttctgcc atgcccaccg
    10381 ccaggcgggc ggacggtcag ccgtcgtcct ccggtgtttc cgccaccgga ctgcgcaagt
    10441 cgtacggtga gaagaccgtt ctcgacggta tcgacatcca tgttccggcc gggaccgtgt
    10501 tcgcgctgct cgggccgaac ggtgccggga agacgaccgc ggtgaagatc ctctccacgc
    10561 tgatctccgc cgacgaggga caggcccggg tcggggggca cgatctggcc accgaggcgc
    10621 atgccatccg gggtgcgatc ggtgtcaccg ggcagttctc cgcggtcgac gggctgatca
    10681 ccggcgagga gaacatgttc ctcatggcgg atctgcacca tctgcccaag agcgagggcc
    10741 gccgggtcgc cgccgagctg ctggagcgct tcgacctcac cgaggccgcc aagaagcccg
    10801 cctccaccta ttccggcggt atgaagcgcc ggctcgacat cgcgatgacc cttgtcggca
    10861 gcccgcggat catcttcctc gacgagccca ccaccggcct cgacccccgc gcccgccaca
    10921 acatgtggca gatcatccgc tccctggtct ccggcggtgt caccgtcttc ctcaccaccc
    10981 agtatctgga ggaggccgac gaactcgccg acagcatcgc cctgctgaac aacggcaaga
    11041 tcgccgccca gggcaccgcc gaagagctca agcggctcat tcccggcggg catgtccgtc
    11101 tccgcttctc caaccccgcc acctatcaga gcgcggcgtc gtccctgcgc gacgccaccc
    11161 gggacgacga ggccatggcc ctccagatcc ccagcgacgg cagccagcgc gaactccgcg
    11221 ccatcctcga ctggctggat tccaccggta tcgaagccga cgaact
//
