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Overview
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1.11

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP031605.1 (Staphylococcus pseudintermedius)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | sactipeptide | 27,031 | 48,575 | Low | subtilosin A | ribosomal:RiPP:Thiopeptide
Region 2 | opine-like-metallophore | 87,628 | 109,735 | High | staphylopine | other:other
Region 3 | RiPP-like | 124,754 | 135,044 |  |
Region 4 | NI-siderophore | 959,911 | 992,910 | High | staphyloferrin A | other:non-nrp siderophore
Region 5 | lanthipeptide-class-iv | 1,092,385 | 1,114,478 |
Region 6 | CDPS,cyclic-lactone-autoinducer | 1,118,901 | 1,147,987 |
Region 7 | RiPP-like | 1,186,103 | 1,197,146 |
Region 8 | terpene-precursor | 1,617,290 | 1,638,171 |  |
Region 9 | RiPP-like | 2,450,093 | 2,462,243 |
Region 10 | NI-siderophore | 2,535,802 | 2,570,254 | High | staphyloferrin B | other:other
Region 11 | azole-containing-RiPP | 2,725,103 | 2,747,155 |

NZ_CP031605.1 - Region 1 - sactipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 27,031 - 48,575 nt. (total: 21,545 nt) Show pHMM detection rules used
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Sactipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | sactipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.5 |  | 0.57 | ribosomal | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000600.3 |  | 0.44 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000906.3 |  | 0.31 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000905.5 |  | 0.31 | other (other) | heme D1 | Heliobacillus mobilis
BGC0001637.3 |  | 0.29 | NRPS | kleboxymycin | Klebsiella oxytoca
BGC0000339.5 |  | 0.29 | NRPS | echinomycin | Streptomyces lasaliensis
BGC0000415.5 |  | 0.28 | NRPS | quinomycin | Streptomyces griseovariabilis subsp. bandungensis
BGC0001228.5 |  | 0.28 | NRPS | retimycin A | Salinispora arenicola CNT005
BGC0000450.5 |  | 0.28 | NRPS | triostin A | Streptomyces triostinicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.5 |  | 0.57 | ribosomal | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000600.3 |  | 0.44 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000906.3 |  | 0.31 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000905.5 |  | 0.31 | other (other) | heme D1 | Heliobacillus mobilis
BGC0001637.3 |  | 0.29 | NRPS | kleboxymycin | Klebsiella oxytoca
BGC0000339.5 |  | 0.29 | NRPS | echinomycin | Streptomyces lasaliensis
BGC0000415.5 |  | 0.28 | NRPS | quinomycin | Streptomyces griseovariabilis subsp. bandungensis
BGC0001228.5 |  | 0.28 | NRPS | retimycin A | Salinispora arenicola CNT005
BGC0000450.5 |  | 0.28 | NRPS | triostin A | Streptomyces triostinicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Sactipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Sactipeptide(s) for DRC71_RS00165

DRC71_RS00165
Leader:
MEKGIMVSNK
Core:
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS

#### antiSMASH-DB 4.0 matches for DRC71_RS00165

100.0%
NC_014925.1 and 17 others:
NZ_ANOI01000001.1 Sactipeptides: F779_RS13290_sactipeptide NZ_CP031604.1 Sactipeptides: DNJ55_RS07055_sactipeptide NZ_CP031605.1 Sactipeptides: DRC71_RS00165_sactipeptide NZ_CP035741.1 Sactipeptides: EW136_RS01865_sactipeptide NZ_CP039747.1 Sactipeptides: EFT29_RS00935_sactipeptide NZ_CP054206.2 Sactipeptides: HP560_RS11995_sactipeptide NZ_CP060700.1 Sactipeptides: H9Q12_RS10940_sactipeptide NZ_CP065920.1 Sactipeptides: JC281_RS11580_sactipeptide NZ_CP076465.1 Sactipeptides: KDE16_RS00560_sactipeptide NZ_JANPRJ010000013.1 Sactipeptides: NVR03_RS10250_sactipeptide NZ_JANPRN010000039.1 Sactipeptides: NVR04_RS07875_sactipeptide NZ_JTKO01000012.1 Sactipeptides: NO87_RS10650_sactipeptide NZ_LR134267.1 Sactipeptides: EL085_RS11430_sactipeptide NZ_MQMO01000006.1 Sactipeptides: BSR38_RS07375_sactipeptide NZ_MQNF01000024.1 Sactipeptides: BSR36_RS12515_sactipeptide NZ_QQPJ01000025.1 Sactipeptides: DV949_RS11300_sactipeptide NZ_SEZW01000001.1 Sactipeptides: EWV33_RS08610_sactipeptide
Sactipeptides: SPSINT_RS00615_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
97.0%
NZ_CP066885.1:
Sactipeptides: JGZ27_RS11325_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
GCSTCSIG ACLIDGPLPDFEVMGITGIFGLTS
1
GCSTCSIGVACLIDGPLPDFEVMGITGIFGLTS
33
87.9%
NZ_CP027770.1:
Sactipeptides: C7J90_RS04260_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
GCS CSIGAACLIDGP PDFEVMGITG FGL+S
1
GCSACSIGAACLIDGPFPDFEVMGITGTFGLSS
33
with 15 more sequence matches
Only the first 10 are displayed here.
75.8%
NZ_CP094808.1 and 3 others:
NZ_CP094809.1 Sactipeptides: MUA95_RS01320_sactipeptide NZ_CP094813.1 Sactipeptides: MUA84_RS01300_sactipeptide NZ_VKCY01000004.1 Sactipeptides: FNK43_RS05155_sactipeptide
Sactipeptides: MUA11_RS01375_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
GCS C+IGAACL DGP+PDFEV GITG FG+ S
1
GCSACAIGAACLADGPIPDFEVAGITGTFGIAS
33
72.7%
NC_000964.3 and 235 others:
NC_014479.1 Sactipeptides: BSUW23_RS18740_sactipeptide NC_014639.1 Sactipeptides: BATR1942_RS15950_sactipeptide NC_014976.1 Sactipeptides: BSN5_RS09700_sactipeptide NC_016047.1 Sactipeptides: GYO_RS41165_sactipeptide NC_017195.1 Sactipeptides: I33_RS18040_sactipeptide NC_017743.1 Sactipeptides: MY9_RS18920_sactipeptide NC_019896.1 Sactipeptides: A7A1_RS01935_sactipeptide NC_020244.1 Sactipeptides: C663_RS18295_sactipeptide NZ_BDDH01000003.1 Sactipeptides: A7P71_RS10610_sactipeptide NZ_CABIVP010000002.1 Sactipeptides: FY199_RS09010_sactipeptide NZ_CP007409.1 Sactipeptides: Q433_RS18950_sactipeptide NZ_CP009796.1 Sactipeptides: OB04_RS19085_sactipeptide NZ_CP011101.1 Sactipeptides: bslm_RS18365_sactipeptide NZ_CP011534.1 Sactipeptides: ABA10_RS18725_sactipeptide NZ_CP011802.1 Sactipeptides: D068_RS17505_sactipeptide NZ_CP016767.1 Sactipeptides: BCV50_RS14935_sactipeptide NZ_CP017072.1 Sactipeptides: BGM23_RS02945_sactipeptide NZ_CP017112.1 Sactipeptides: BS16045_RS19810_sactipeptide NZ_CP017313.1 Sactipeptides: BH660_RS14630_sactipeptide NZ_CP017314.1 Sactipeptides: BSBS38_RS19215_sactipeptide NZ_CP017676.1 Sactipeptides: BKN48_RS08085_sactipeptide NZ_CP018173.1 Sactipeptides: BAX60_RS03615_sactipeptide NZ_CP020367.1 Sactipeptides: BSK2_RS19060_sactipeptide NZ_CP020722.1 Sactipeptides: B7470_RS09560_sactipeptide NZ_CP020915.1 Sactipeptides: B9L64_RS11255_sactipeptide NZ_CP021169.1 Sactipeptides: B9N48_RS18685_sactipeptide NZ_CP021498.1 Sactipeptides: S101444_RS19170_sactipeptide NZ_CP021892.1 Sactipeptides: S100333_RS19720_sactipeptide NZ_CP021903.1 Sactipeptides: CD007_RS18975_sactipeptide NZ_CP021911.1 Sactipeptides: CDO84_RS18225_sactipeptide NZ_CP021921.1 Sactipeptides: S101392_RS19440_sactipeptide NZ_CP022391.1 Sactipeptides: CFK25_RS18875_sactipeptide NZ_CP022890.1 Sactipeptides: CJZ70_RS01210_sactipeptide NZ_CP023257.1 Sactipeptides: CLD04_RS19470_sactipeptide NZ_CP023409.1 Sactipeptides: Bateq7PJ16_RS20450_sactipeptide NZ_CP025941.1 Sactipeptides: C0W65_RS07300_sactipeptide NZ_CP026010.1 Sactipeptides: BS11774_RS03710_sactipeptide NZ_CP026030.1 Sactipeptides: C2H91_RS12110_sactipeptide NZ_CP026035.1 Sactipeptides: C2H96_RS13375_sactipeptide NZ_CP026036.1 Sactipeptides: C2H93_RS16885_sactipeptide NZ_CP026521.1 Sactipeptides: C1T29_RS22385_sactipeptide NZ_CP028201.1 Sactipeptides: C7M16_RS17535_sactipeptide NZ_CP028202.1 Sactipeptides: C7M17_RS17600_sactipeptide NZ_CP028217.1 Sactipeptides: C7M29_RS06900_sactipeptide NZ_CP028218.1 Sactipeptides: C7M30_RS12605_sactipeptide NZ_CP028812.1 Sactipeptides: DAE22_RS20770_sactipeptide NZ_CP029364.1 Sactipeptides: DIC78_RS12275_sactipeptide NZ_CP029461.1 Sactipeptides: DJ572_RS18795_sactipeptide NZ_CP029465.1 Sactipeptides: DKG76_RS19825_sactipeptide NZ_CP029609.1 Sactipeptides: DL538_RS20030_sactipeptide NZ_CP031675.1 Sactipeptides: DYS67_RS19275_sactipeptide NZ_CP031783.1 Sactipeptides: D0808_RS00710_sactipeptide NZ_CP031784.1 Sactipeptides: D0819_RS14700_sactipeptide NZ_CP032853.1 Sactipeptides: D9C10_RS17955_sactipeptide NZ_CP032855.1 Sactipeptides: D9C11_RS09165_sactipeptide NZ_CP035161.1 Sactipeptides: EQH88_RS19675_sactipeptide NZ_CP035167.1 Sactipeptides: EQJ08_RS19095_sactipeptide NZ_CP035226.1 Sactipeptides: EQW70_RS20085_sactipeptide NZ_CP035231.1 Sactipeptides: EQZ01_RS19685_sactipeptide NZ_CP035391.1 Sactipeptides: ES965_RS19370_sactipeptide NZ_CP035395.1 Sactipeptides: ES968_RS19740_sactipeptide NZ_CP035401.1 Sactipeptides: ETA19_RS19595_sactipeptide NZ_CP035402.1 Sactipeptides: ES969_RS19660_sactipeptide NZ_CP035403.1 Sactipeptides: ETA15_RS19805_sactipeptide NZ_CP035406.1 Sactipeptides: ETK61_RS20735_sactipeptide NZ_CP035413.1 Sactipeptides: ETL58_RS19505_sactipeptide NZ_CP039935.1 Sactipeptides: FCJ76_RS19255_sactipeptide NZ_CP045006.1 Sactipeptides: F9B13_RS01950_sactipeptide NZ_CP045425.1 Sactipeptides: GCU76_RS20710_sactipeptide NZ_CP045816.1 Sactipeptides: GII86_RS19920_sactipeptide NZ_CP045824.1 Sactipeptides: GII78_RS20125_sactipeptide NZ_CP046591.1 Sactipeptides: GO004_RS15965_sactipeptide NZ_CP046860.1 Sactipeptides: GPJ55_RS11605_sactipeptide NZ_CP047645.1 Sactipeptides: GSN02_RS19265_sactipeptide NZ_CP049924.1 Sactipeptides: G4G26_RS18960_sactipeptide NZ_CP050705.1 Sactipeptides: HCU65_RS18920_sactipeptide NZ_CP051462.1 Sactipeptides: HC662_RS19240_sactipeptide NZ_CP051464.1 Sactipeptides: HC660_RS18970_sactipeptide NZ_CP054050.1 Sactipeptides: HNV25_RS02005_sactipeptide NZ_CP054177.1 Sactipeptides: HR084_RS18935_sactipeptide NZ_CP054584.1 Sactipeptides: HT135_RS19775_sactipeptide NZ_CP060193.1 Sactipeptides: H7F27_RS02180_sactipeptide NZ_CP060417.1 Sactipeptides: H8S71_RS18495_sactipeptide NZ_CP061284.1 Sactipeptides: ICJ61_RS19715_sactipeptide NZ_CP061870.1 Sactipeptides: IE382_RS22305_sactipeptide NZ_CP062497.1 Sactipeptides: IHV08_RS19770_sactipeptide NZ_CP063276.1 Sactipeptides: IM743_RS18070_sactipeptide NZ_CP065858.1 Sactipeptides: I7X10_RS03370_sactipeptide NZ_CP069789.1 Sactipeptides: JR441_RS19085_sactipeptide NZ_CP070483.1 Sactipeptides: JQX68_RS19175_sactipeptide NZ_CP070976.1 Sactipeptides: JYG31_RS19675_sactipeptide NZ_CP071043.1 Sactipeptides: JS609_RS19245_sactipeptide NZ_CP073265.1 Sactipeptides: KCX77_RS18900_sactipeptide NZ_CP075344.1 Sactipeptides: KIL00_RS20100_sactipeptide NZ_CP076083.1 Sactipeptides: KFF76_RS18635_sactipeptide NZ_CP079759.1 Sactipeptides: KXZ66_RS19695_sactipeptide NZ_CP080508.1 Sactipeptides: K0V03_RS08595_sactipeptide NZ_CP089148.1 Sactipeptides: LRO88_RS20980_sactipeptide NZ_CP090125.1 Sactipeptides: LXE94_RS19505_sactipeptide NZ_CP093289.1 Sactipeptides: MNG38_RS19730_sactipeptide NZ_CP093546.1 Sactipeptides: MOW04_RS19180_sactipeptide NZ_CP095736.1 Sactipeptides: MX663_RS20090_sactipeptide NZ_CP096590.1 Sactipeptides: M0696_RS18995_sactipeptide NZ_CP096889.1 Sactipeptides: EFK13_RS19225_sactipeptide NZ_CP098738.1 Sactipeptides: NDR85_RS18965_sactipeptide NZ_CP100651.1 Sactipeptides: NLW79_RS19990_sactipeptide NZ_CP100752.1 Sactipeptides: NLV76_RS19060_sactipeptide NZ_CP101718.1 Sactipeptides: NPA28_RS19075_sactipeptide NZ_CP101936.1 Sactipeptides: NP434_RS18980_sactipeptide NZ_CP103352.1 Sactipeptides: NX823_RS19780_sactipeptide NZ_CP104878.1 Sactipeptides: N8A75_RS20105_sactipeptide NZ_CP107539.1 Sactipeptides: OEG95_RS19105_sactipeptide NZ_CP110264.1 Sactipeptides: OMK57_RS18975_sactipeptide NZ_CP114899.1 Sactipeptides: O6U12_RS19480_sactipeptide NZ_CP116773.1 Sactipeptides: PNF29_RS01990_sactipeptide NZ_FTMW01000001.1 Sactipeptides: BW968_RS02045_sactipeptide NZ_JAAUXF010000005.1 Sactipeptides: HC742_RS19325_sactipeptide NZ_JABRUZ010000003.1 Sactipeptides: HRF55_RS03085_sactipeptide NZ_JABRVH010000018.1 Sactipeptides: HRF53_RS09100_sactipeptide NZ_JABUKD010000002.1 Sactipeptides: HRW04_RS09345_sactipeptide NZ_JAEACL010000001.1 Sactipeptides: I5F14_RS00800_sactipeptide NZ_JAHVOC010000002.1 Sactipeptides: KXD37_RS07830_sactipeptide NZ_JAJFDG010000003.1 Sactipeptides: LJF29_RS11575_sactipeptide NZ_JAJHUI010000011.1 Sactipeptides: LK399_RS16325_sactipeptide NZ_JALAJC010000012.1 Sactipeptides: MOB18_RS16080_sactipeptide NZ_JALAKW010000005.1 Sactipeptides: MOB93_RS12665_sactipeptide NZ_JALAKZ010000001.1 Sactipeptides: MOB76_RS02240_sactipeptide NZ_JALALA010000011.1 Sactipeptides: MOB82_RS15020_sactipeptide NZ_JALALE010000020.1 Sactipeptides: MOB33_RS20855_sactipeptide NZ_JALALO010000006.1 Sactipeptides: MOB75_RS09230_sactipeptide NZ_JALAMD010000002.1 Sactipeptides: MOB22_RS02315_sactipeptide NZ_JALAME010000005.1 Sactipeptides: MOC02_RS13805_sactipeptide NZ_JALAMJ010000012.1 Sactipeptides: MOB80_RS16635_sactipeptide NZ_JALAMO010000007.1 Sactipeptides: MOB98_RS08535_sactipeptide NZ_JALAMR010000019.1 Sactipeptides: MOC09_RS17975_sactipeptide NZ_JALAMZ010000002.1 Sactipeptides: MOC43_RS01370_sactipeptide NZ_JALANN010000012.1 Sactipeptides: MOC49_RS18290_sactipeptide NZ_JALANX010000001.1 Sactipeptides: MOC25_RS03365_sactipeptide NZ_JALAPT010000001.1 Sactipeptides: MOC95_RS01580_sactipeptide NZ_JALAPV010000005.1 Sactipeptides: MOC91_RS13515_sactipeptide NZ_JALAPW010000003.1 Sactipeptides: MOD18_RS06235_sactipeptide NZ_JALAPX010000003.1 Sactipeptides: MOC97_RS06805_sactipeptide NZ_JALAPZ010000002.1 Sactipeptides: MOC81_RS03830_sactipeptide NZ_JALAQA010000008.1 Sactipeptides: MOD07_RS14955_sactipeptide NZ_JALAQC010000001.1 Sactipeptides: MOD00_RS01290_sactipeptide NZ_JALAQD010000002.1 Sactipeptides: MOD08_RS05770_sactipeptide NZ_JALAQE010000002.1 Sactipeptides: MOD19_RS04725_sactipeptide NZ_JALASB010000002.1 Sactipeptides: MOD42_RS03685_sactipeptide NZ_JALASC010000024.1 Sactipeptides: MOD69_RS20580_sactipeptide NZ_JALASM010000006.1 Sactipeptides: MOD51_RS10970_sactipeptide NZ_JALASR010000006.1 Sactipeptides: MOD87_RS10780_sactipeptide NZ_JALAST010000011.1 Sactipeptides: MOE17_RS14670_sactipeptide NZ_JALASW010000005.1 Sactipeptides: MOE15_RS06925_sactipeptide NZ_JALATC010000001.1 Sactipeptides: MOD56_RS03380_sactipeptide NZ_JALATD010000001.1 Sactipeptides: MOE02_RS03350_sactipeptide NZ_JALATE010000006.1 Sactipeptides: MOD98_RS11440_sactipeptide NZ_JALATF010000003.1 Sactipeptides: MOD44_RS09960_sactipeptide NZ_JALATG010000002.1 Sactipeptides: MOE16_RS03490_sactipeptide NZ_JALATJ010000007.1 Sactipeptides: MOD90_RS15770_sactipeptide NZ_JALATU010000001.1 Sactipeptides: MOE27_RS01985_sactipeptide NZ_JALATV010000005.1 Sactipeptides: MOD97_RS07020_sactipeptide NZ_JALAUA010000008.1 Sactipeptides: MOD32_RS16030_sactipeptide NZ_JALAUD010000001.1 Sactipeptides: MOE28_RS03345_sactipeptide NZ_JALAUJ010000006.1 Sactipeptides: MOE37_RS12685_sactipeptide NZ_JALAUK010000012.1 Sactipeptides: MOE38_RS11825_sactipeptide NZ_JALAUV010000003.1 Sactipeptides: MOE71_RS06545_sactipeptide NZ_JALAUW010000015.1 Sactipeptides: MOE83_RS13210_sactipeptide NZ_JALAVA010000002.1 Sactipeptides: MOE81_RS02625_sactipeptide NZ_JALAVE010000001.1 Sactipeptides: MOE67_RS03645_sactipeptide NZ_JALAVI010000011.1 Sactipeptides: MOE80_RS14660_sactipeptide NZ_JALAVK010000006.1 Sactipeptides: MOE96_RS10120_sactipeptide NZ_JALAVL010000002.1 Sactipeptides: MOE60_RS03290_sactipeptide NZ_JALAVM010000009.1 Sactipeptides: MOE49_RS16195_sactipeptide NZ_JALAVO010000008.1 Sactipeptides: MOE63_RS14665_sactipeptide NZ_JALAVQ010000003.1 Sactipeptides: MOE59_RS02420_sactipeptide NZ_JALAVS010000002.1 Sactipeptides: MOE46_RS02250_sactipeptide NZ_JALAVT010000005.1 Sactipeptides: MOF25_RS08325_sactipeptide NZ_JALAVU010000004.1 Sactipeptides: MOE78_RS09660_sactipeptide NZ_JALAVV010000004.1 Sactipeptides: MOE66_RS02855_sactipeptide NZ_JALAVW010000001.1 Sactipeptides: MOE86_RS01005_sactipeptide NZ_JALAVX010000009.1 Sactipeptides: MOE40_RS07525_sactipeptide NZ_JALAVZ010000002.1 Sactipeptides: MOF00_RS02525_sactipeptide NZ_JALAWB010000008.1 Sactipeptides: MOE87_RS15020_sactipeptide NZ_JALAWK010000002.1 Sactipeptides: MOF06_RS12140_sactipeptide NZ_JALAWW010000010.1 Sactipeptides: MOF23_RS17300_sactipeptide NZ_JALAXQ010000012.1 Sactipeptides: MOF24_RS14120_sactipeptide NZ_JALAXV010000001.1 Sactipeptides: MOF15_RS00375_sactipeptide NZ_JALAYA010000016.1 Sactipeptides: MOF34_RS08915_sactipeptide NZ_JALAYD010000019.1 Sactipeptides: MOF39_RS20725_sactipeptide NZ_JALNTO010000006.1 Sactipeptides: MTN95_RS11045_sactipeptide NZ_JAMDFN010000008.1 Sactipeptides: M3M31_RS18245_sactipeptide NZ_JAMYDW010000003.1 Sactipeptides: NHM07_RS10830_sactipeptide NZ_JANBMP010000002.1 Sactipeptides: NL430_RS07940_sactipeptide NZ_JANDGG010000001.1 Sactipeptides: NKU38_RS03365_sactipeptide NZ_JANFAP010000001.1 Sactipeptides: NEC81_RS02065_sactipeptide NZ_JAQFFE010000015.1 Sactipeptides: PG051_RS13540_sactipeptide NZ_JAQOXM010000001.1 Sactipeptides: PO770_RS01950_sactipeptide NZ_JH600279.1 Sactipeptides: GYU_RS0104160_sactipeptide NZ_JXHL01000020.1 Sactipeptides: B4069_RS07025_sactipeptide NZ_JXHP01000031.1 Sactipeptides: B4073_RS09425_sactipeptide NZ_JXHR01000010.1 Sactipeptides: B4146_RS06925_sactipeptide NZ_KZ848487.1 Sactipeptides: DSL71_RS14015_sactipeptide NZ_LPVE01000021.1 Sactipeptides: AU385_RS06600_sactipeptide NZ_LSBB01000001.1 Sactipeptides: AXI57_RS01770_sactipeptide NZ_LUUT01000004.1 Sactipeptides: A6751_RS18460_sactipeptide NZ_MOEO01000004.1 Sactipeptides: BLL41_RS09830_sactipeptide NZ_MUXL01000002.1 Sactipeptides: B0W20_RS08845_sactipeptide NZ_MZZI01000001.1 Sactipeptides: B2G85_RS18515_sactipeptide NZ_NBBO01000003.1 Sactipeptides: B6K89_RS01830_sactipeptide NZ_NERK01000024.1 Sactipeptides: B9T64_RS18540_sactipeptide NZ_NJRD01000003.1 Sactipeptides: CE053_RS09115_sactipeptide NZ_NJRE01000002.1 Sactipeptides: CE047_RS07205_sactipeptide NZ_NKAK01000003.1 Sactipeptides: CE489_RS10400_sactipeptide NZ_NMOM01000004.1 Sactipeptides: CFI07_RS07245_sactipeptide NZ_PHIE01000002.1 Sactipeptides: CVV77_RS10760_sactipeptide NZ_PJCT01000002.1 Sactipeptides: CW370_RS11825_sactipeptide NZ_PVQM01000002.1 Sactipeptides: C6W22_RS11490_sactipeptide NZ_PVQN01000002.1 Sactipeptides: C6W23_RS05885_sactipeptide NZ_PVRK01000001.1 Sactipeptides: C6350_RS02025_sactipeptide NZ_PVWC01000004.1 Sactipeptides: C6372_RS11675_sactipeptide NZ_QRFZ01000012.1 Sactipeptides: DXT72_RS19010_sactipeptide NZ_SDKE01000003.1 Sactipeptides: EUA35_RS12130_sactipeptide NZ_SHOB01000002.1 Sactipeptides: ES060_RS14270_sactipeptide NZ_SIRN01000006.1 Sactipeptides: EYH65_RS15720_sactipeptide NZ_SNWK01000001.1 Sactipeptides: DFO69_RS02055_sactipeptide NZ_SOBO01000012.1 Sactipeptides: DFO78_RS18210_sactipeptide NZ_SORJ01000001.1 Sactipeptides: BJ795_RS03350_sactipeptide NZ_VBRP01000025.1 Sactipeptides: FE220_RS07065_sactipeptide NZ_VFNF01000001.1 Sactipeptides: FB592_RS03405_sactipeptide NZ_VIOH01000001.1 Sactipeptides: FLN47_RS01935_sactipeptide NZ_VLJK01000012.1 Sactipeptides: L605_RS10195_sactipeptide NZ_VLJL01000006.1 Sactipeptides: L604_RS05585_sactipeptide NZ_VLJX01000001.1 Sactipeptides: L609_RS01950_sactipeptide NZ_VTEK01000003.1 Sactipeptides: FZC71_RS10310_sactipeptide NZ_WTKJ01000004.1 Sactipeptides: NWT17_RS06185_sactipeptide
Sactipeptides: BSU_37350_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGL
31
GC+TCSIGAACL+DGP+PDFE+ G TG+FGL
1
GCATCSIGAACLVDGPIPDFEIAGATGLFGL
31
72.7%
NZ_ATDF02000020.1 and 1 other:
NZ_KV827785.1 Sactipeptides: HMPREF2580_RS10900_sactipeptide
Sactipeptides: M462_RS08950_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
GCS C++GAACL DGP+PDFEV GITG FG+ S
1
GCSACAVGAACLADGPIPDFEVAGITGTFGMAS
33
72.7%
NZ_CP048852.1:
Sactipeptides: G4P54_RS19300_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGL
31
GC+TCSIGA CL+DGP+PDFEV G TG+FGL
1
GCATCSIGAVCLVDGPIPDFEVAGATGLFGL
31
69.7%
NZ_CP063367.1 and 1 other:
NZ_LR134263.1 Sactipeptides: EL101_RS12790_sactipeptide
Sactipeptides: IPU22_RS12430_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS
33
GCS C++GA CL DGP+PDFEV GITG FG+ S
1
GCSACAVGAVCLADGPIPDFEVAGITGTFGIAS
33
69.7%
NZ_CP092751.1:
Sactipeptides: MKF32_RS18515_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGL
31
GC+TCSIGA CL+DGP+PDFE+ G TG+FGL
1
GCATCSIGAVCLVDGPIPDFEIAGATGLFGL
31
69.7%
NZ_JALAKO010000018.1 and 1 other:
NZ_JALAOG010000035.1 Sactipeptides: MOC96_RS18415_sactipeptide
Sactipeptides: MOB26_RS11095_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGL
31
GC+TCSIGA CL+DGP+PDFE+ G+TG+FGL
1
GCATCSIGAVCLVDGPIPDFEIGGVTGLFGL
31
66.7%
NZ_CP026362.1 and 3 others:
NZ_CP033052.1 Sactipeptides: D9779_RS19215_sactipeptide NZ_JALAPG010000031.1 Sactipeptides: MOC70_RS13155_sactipeptide NZ_JALAQI010000016.1 Sactipeptides: MOD13_RS11485_sactipeptide
Sactipeptides: BV11031_RS20865_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGL
31
GC+TCSIGA CL+DG +PDFE+ G+TG+FGL
1
GCATCSIGAVCLVDGFIPDFEIGGVTGLFGL
31
66.7%
NZ_LGRV01000006.1:
Sactipeptides: AEA09_RS16245_sactipeptide
1
GCSTCSIGAACLIDGPLPDFEVMGITGIFGL
31
GCS CSIGA CLI GP+PDFEV I+GIF +
1
GCSACSIGAICLITGPVPDFEVASISGIFSV
31
63.6%
NZ_CP066713.1:
Sactipeptides: JGZ50_RS11620_sactipeptide
2
CSTCSIGAACLIDGPLPDFEVMGITGIF
29
CSTCSIGAACLIDGPLPDF G F
1
CSTCSIGAACLIDGPLPDFRSHGNYWNF
28

#### MIBiG 4.0 matches for DRC71_RS00165

21.2%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
15
GPLPDFEVMGIT
26
GPL E+ GIT
2
GPLAGEEMGGIT
13
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.74 out of 29.51
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.22 out of 30.25
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.06 out of 18.46
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97
Confidence: medium
Additional weak hits (8):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.51 out of 30.25
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 22.46 out of 30.12
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.43 out of 30.11
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.15 out of 31.73
Confidence: weak
RREFinder
Sactipeptides
TFBS Finder
RRE predictions
RREfinder results sidepanel.

sactipeptide protocluster (27030...48575)
DRC71_RS13600
  RRE type: Subtilosin_rSAM_RRE
  Location: 24 - 94
  Score: 72.7

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its RODEO score and predicted core sequence.

DRC71_RS00165
  Putative sactipeptide
  RODEO score: 31.0
  Core sequence, approximate: GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
DosR | Hypoxia stress response regulator
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP031605.1 - Region 2 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 87,628 - 109,735 nt. (total: 22,108 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Translocases: permease
DRC71_RS00470: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002487.3 |  | 0.81 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3 |  | 0.79 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002489.2 |  | 0.63 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000488.4 |  | 0.39 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002115.3 |  | 0.38 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002568.2 |  | 0.38 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22
BGC0002656.2 |  | 0.37 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002487.3 |  | 0.81 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3 |  | 0.79 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002489.2 |  | 0.63 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000488.4 |  | 0.39 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002115.3 |  | 0.38 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002568.2 |  | 0.38 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22
BGC0002656.2 |  | 0.37 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.23 out of 29.38
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 32.93
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (2):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.20 out of 25.88
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.17 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 3 | Repressor of DNA damage response
ZuR variant 1 | Zinc-responsive repressor

NZ_CP031605.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 124,754 - 135,044 nt. (total: 10,291 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
DRC71_RS00575: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

DRC71_RS00580: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002144.3 |  | 0.41 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0000500.5 |  | 0.40 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001525.3 |  | 0.40 | other (other) | bartoloside B, bartoloside C, bartoloside D | Synechocystis salina LEGE 06155

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002144.3 |  | 0.41 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0000500.5 |  | 0.40 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001525.3 |  | 0.40 | other (other) | bartoloside B, bartoloside C, bartoloside D | Synechocystis salina LEGE 06155

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.72 out of 26.06
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.83 out of 28.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.15 out of 28.19
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP031605.1 - Region 4 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 959,911 - 992,910 nt. (total: 33,000 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
DRC71_RS04300: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.5 |  | 0.79 | other (non-nrp siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3 |  | 0.56 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000939.5 |  | 0.56 | other (other) | aerobactin | Grimontia hollisae
BGC0002682.2 |  | 0.55 | other (other) | aerobactin | Vibrio mimicus
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002073.3 |  | 0.52 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002683.2 |  | 0.49 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0000943.5 |  | 0.47 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001948.3 |  | 0.43 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0002681.3 |  | 0.41 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.5 |  | 0.79 | other (non-nrp siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3 |  | 0.56 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000939.5 |  | 0.56 | other (other) | aerobactin | Grimontia hollisae
BGC0002682.2 |  | 0.55 | other (other) | aerobactin | Vibrio mimicus
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002073.3 |  | 0.52 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002683.2 |  | 0.49 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0000943.5 |  | 0.47 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001948.3 |  | 0.43 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0002681.3 |  | 0.41 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.41 out of 29.38
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.02 out of 32.74
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.40 out of 21.55
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.29 out of 24.78
Confidence: medium
Additional weak hits (2):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.37 out of 30.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.03 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response

NZ_CP031605.1 - Region 5 - lanthipeptide-class-iv
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,092,385 - 1,114,478 nt. (total: 22,094 nt) Show pHMM detection rules used
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase
DRC71_RS04975: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

DRC71_RS04995: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iv | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.48 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.46 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5 |  | 0.45 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000518.3 |  | 0.41 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001859.4 |  | 0.38 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001441.5 |  | 0.38 | other (other) | belactosin A, belactosin C | Streptomyces sp.
BGC0000904.5 |  | 0.35 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0001371.4 |  | 0.30 | NRPS | echinocandin B | Aspergillus nidulans NRRL 8112
BGC0002611.2 |  | 0.30 | NRPS | mulundocandin | Aspergillus mulundensis
BGC0000842.5 |  | 0.29 | other (non-nrp beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.48 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.46 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5 |  | 0.45 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000518.3 |  | 0.41 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001859.4 |  | 0.38 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001441.5 |  | 0.38 | other (other) | belactosin A, belactosin C | Streptomyces sp.
BGC0000904.5 |  | 0.35 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0001371.4 |  | 0.30 | NRPS | echinocandin B | Aspergillus nidulans NRRL 8112
BGC0002611.2 |  | 0.30 | NRPS | mulundocandin | Aspergillus mulundensis
BGC0000842.5 |  | 0.29 | other (non-nrp beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for DRC71_RS04965

DRC71_RS04960
Leader:
MNRVLKLQKLNAEFETKNAK
Core:
VIFTAGCHIQIN
Core with dehydrations:
VIFDhbAGCysHIQIN

#### antiSMASH-DB 4.0 matches for DRC71_RS04960

100.0%
NZ_CP009120.1 and 4 others:
NZ_CP031605.1 Lanthipeptides: DRC71_RS04960_lanthipeptide NZ_CP039745.1 Lanthipeptides: allorf_0867458_0867574_lanthipeptide NZ_CP065926.1 Lanthipeptides: JC283_RS03835_lanthipeptide NZ_SEZZ01000002.1 Lanthipeptides: allorf_1859398_1859514_lanthipeptide
Lanthipeptides: allorf_0814517_0814633_lanthipeptide
1
VIFTAGCHIQIN
12
VIFTAGCHIQIN
1
VIFTAGCHIQIN
12
73.3%
NZ_CP048279.1:
Lanthipeptides: GZH82_RS13950_lanthipeptide
1
VIFTAGCHIQI
11
VIFTAGCHIQI
1
VIFTAGCHIQI
11

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.71 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.91 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.91 out of 28.19
Confidence: medium
Additional weak hits (7):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.73 out of 33.14
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.19 out of 20.01
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.80 out of 30.22
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.56 out of 32.74
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.82 out of 29.65
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

DRC71_RS04960 - Class III
  Cleavage pHMM score: -1.80
  RODEO score: 0
  Monoisotopic mass: 1296.7 Da
  Molecular weight: 1297.5 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_CP031605.1 - Region 6 - CDPS,cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,118,901 - 1,147,987 nt. (total: 29,087 nt) Show pHMM detection rules used
CDPS: CDPS
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
DRC71_RS05075: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: kinase
DRC71_RS05095: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: deacetylase
DRC71_RS05155: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: hydratase
DRC71_RS05125: Nitrilase/cyanide hydratase and apolipoprotein

smcogs
  SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | CDPS | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002103.2 |  |  | 0.63 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0002667.2 |  |  | 0.29 | ribosomal | estericin A | Clostridium estertheticum
BGC0001291.3 |  |  | 0.28 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0000540.5 |  |  | 0.25 | ribosomal | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0002579.2 |  |  | 0.23 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  |  | 0.21 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000193.3 |  |  | 0.20 | PKS | aclacinomycin | Streptomyces galilaeus
BGC0000346.5 |  |  | 0.19 | NRPS, PKS | epoxomicin | Goodfellowiella coeruleoviolacea
BGC0000876.5 |  |  | 0.19 | other (other) | neopolyoxin C | Streptomyces tendae
BGC0000651.5 |  |  | 0.18 | terpene | KS-505a | Streptomyces argenteolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002103.2 |  | 0.69 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0002667.2 |  | 0.47 | ribosomal | estericin A | Clostridium estertheticum
BGC0001291.3 |  | 0.45 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0000540.5 |  | 0.41 | ribosomal | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001171.5 |  | 0.41 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0001687.3 |  | 0.40 | other (other) | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0002313.3 |  | 0.40 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000882.5 |  | 0.40 | other (other) | mildiomycin | Streptomyces rimofaciens
BGC0000193.3 |  | 0.39 | PKS | aclacinomycin | Streptomyces galilaeus
BGC0002579.2 |  | 0.39 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.01 out of 27.78
Confidence: strong
Additional weak hits (1):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.58 out of 31.73
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP031605.1 - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,186,103 - 1,197,146 nt. (total: 11,044 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.3 |  | 0.39 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0000497.3 |  | 0.36 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001929.2 |  | 0.36 | ribosomal | WGK | Streptococcus ferus
BGC0002583.2 |  | 0.36 | ribosomal | tryglysin B | Streptococcus mutans UA159
BGC0002713.2 |  | 0.24 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001100.5 |  | 0.23 | NRPS, PKS | lankacidin C | Streptomyces rochei
BGC0002122.2 |  | 0.22 | NRPS | gramicidin S | Aneurinibacillus migulanus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.3 |  | 0.39 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0000497.3 |  | 0.36 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001929.2 |  | 0.36 | ribosomal | WGK | Streptococcus ferus
BGC0002583.2 |  | 0.36 | ribosomal | tryglysin B | Streptococcus mutans UA159
BGC0002713.2 |  | 0.24 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001100.5 |  | 0.23 | NRPS, PKS | lankacidin C | Streptomyces rochei
BGC0002122.2 |  | 0.22 | NRPS | gramicidin S | Aneurinibacillus migulanus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.13 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.21 out of 32.93
Confidence: medium
Additional weak hits (2):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.45 out of 30.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.42 out of 29.25
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP031605.1 - Region 8 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,617,290 - 1,638,171 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
DRC71_RS07765: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: carboxylase
DRC71_RS07710: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
DRC71_RS07695: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase
DRC71_RS07735: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

DRC71_RS07740: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000234.5 |  | 0.42 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002591.2 |  | 0.41 | PKS, terpene | aurachin C, aurachin D, aurachin SS | Streptomyces sp.
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000905.5 |  | 0.40 | other (other) | heme D1 | Heliobacillus mobilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000234.5 |  | 0.42 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002591.2 |  | 0.41 | PKS, terpene | aurachin C, aurachin D, aurachin SS | Streptomyces sp.
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000905.5 |  | 0.40 | other (other) | heme D1 | Heliobacillus mobilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
DRC71_RS07735: PT_FPPS_like
Domain 1 (29 - 292): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.46 out of 24.78
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05
Confidence: strong
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
LexA variant 2 | Repressor of DNA damage response
PerR | Peroxide regulator

NZ_CP031605.1 - Region 9 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,450,093 - 2,462,243 nt. (total: 12,151 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002674.2 |  | 0.50 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001864.3 |  | 0.50 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001862.4 |  | 0.47 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0001863.4 |  | 0.47 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002586.2 |  | 0.47 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0001861.4 |  | 0.47 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002674.2 |  | 0.50 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001864.3 |  | 0.50 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001862.4 |  | 0.47 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0001863.4 |  | 0.47 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002586.2 |  | 0.47 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0001861.4 |  | 0.47 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_CP031605.1 - Region 10 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,535,802 - 2,570,254 nt. (total: 34,453 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase
DRC71_RS12140: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: deaminase
DRC71_RS12185: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase
DRC71_RS12155: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase
DRC71_RS12190: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.82 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001870.3 |  | 0.57 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002469.2 |  | 0.53 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000947.5 |  | 0.53 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001713.5 |  | 0.50 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0000939.5 |  | 0.50 | other (other) | aerobactin | Grimontia hollisae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.82 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001870.3 |  | 0.57 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002469.2 |  | 0.53 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000947.5 |  | 0.53 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001713.5 |  | 0.50 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0000939.5 |  | 0.50 | other (other) | aerobactin | Grimontia hollisae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.13 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.07 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.57 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (5):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.92 out of 31.73
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.74 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.83 out of 30.11
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.09 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.03 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP031605.1 - Region 11 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,725,103 - 2,747,155 nt. (total: 22,053 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.42 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0001171.5 |  | 0.41 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000564.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000566.5 |  | 0.39 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001391.3 |  | 0.37 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000552.3 |  | 0.36 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.42 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0001171.5 |  | 0.41 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000564.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000566.5 |  | 0.39 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001391.3 |  | 0.37 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000552.3 |  | 0.36 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.45 out of 33.14
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.93 out of 32.93
Confidence: medium
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.31 out of 39.62
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 35.63
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
TFBS Finder
Azole RiPPs
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 2 | Zinc-responsive repressor

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.