GCF_007827695.1 - 13 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_VITA01000003.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	hserlactone	376,674	397,294

NZ_VITA01000004.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	terpene-precursor	223,562	244,476	Low	polyhydroxyalkanoate	other:other

NZ_VITA01000006.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	azole-containing-RiPP	278,484	305,603

NZ_VITA01000007.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	2dos	282,915	317,313

NZ_VITA01000008.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene	72,249	93,091

NZ_VITA01000010.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	redox-cofactor	1,968	24,155

NZ_VITA01000011.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	hserlactone	160,861	181,505

NZ_VITA01000012.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	thioamitides	53,947	75,960

NZ_VITA01000013.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	T1PKS	1	32,960

NZ_VITA01000016.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 16.1	arylpolyene	30,530	71,732

NZ_VITA01000026.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	azole-containing-RiPP	1	23,182

NZ_VITA01000039.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 39.1	lanthipeptide-class-ii	1	13,408

NZ_VITA01000048.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 48.1	thioamitides	1	10,892

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	hserlactone	376,674	397,294
Region 4.1	terpene-precursor	223,562	244,476	Low	polyhydroxyalkanoate	other:other
Region 6.1	azole-containing-RiPP	278,484	305,603
Region 7.1	2dos	282,915	317,313
Region 8.1	terpene	72,249	93,091
Region 10.1	redox-cofactor	1,968	24,155
Region 11.1	hserlactone	160,861	181,505
Region 12.1	thioamitides	53,947	75,960
Region 13.1	T1PKS	1	32,960
Region 16.1	arylpolyene	30,530	71,732
Region 26.1	azole-containing-RiPP	1	23,182
Region 39.1	lanthipeptide-class-ii	1	13,408
Region 48.1	thioamitides	1	10,892

No secondary metabolite regions were found in these records:: NZ_VITA01000001.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000002.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000005.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000009.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000014.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000015.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000017.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000018.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000019.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000020.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000021.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000022.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000023.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000024.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000025.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000027.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000028.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000029.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000030.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000031.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000032.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000033.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000034.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000035.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000036.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000037.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000038.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000040.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000041.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000042.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000043.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000044.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000045.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000046.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000047.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000049.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000050.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000051.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000052.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000053.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000054.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000055.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000056.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000057.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000058.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000059.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000060.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000061.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000062.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000063.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000064.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000065.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000066.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000067.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_VITA01000068.1 (Sinorhizobium medicae (Ensifer medicae))

Compact view

NZ_VITA01000003.1 - Region 1 - hserlactone

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Location: 376,674 - 397,294 nt. (total: 20,621 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001992.3	0.35	other (other)	thioguanine	Erwinia amylovora CFBP1430
BGC0002713.2	0.23	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000453.5	0.22	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0000495.5	0.21	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0000446.5	0.20	NRPS	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0000344.5	0.20	NRPS	entolysin	Pseudomonas entomophila L48
BGC0002336.2	0.18	NRPS	bolagladin A, bolagladin B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001992.3	0.35	other (other)	thioguanine	Erwinia amylovora CFBP1430
BGC0002713.2	0.23	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000453.5	0.22	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0000495.5	0.21	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0000446.5	0.20	NRPS	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0000344.5	0.20	NRPS	entolysin	Pseudomonas entomophila L48
BGC0002336.2	0.18	NRPS	bolagladin A, bolagladin B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97

Confidence: medium

Additional weak hits (5):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.37 out of 29.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.62 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.02 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.31 out of 29.65

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.68 out of 27.18

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
RpoN	Regulator of nitrogen assimilation and virulence

NZ_VITA01000004.1 - Region 1 - terpene-precursor

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Location: 223,562 - 244,476 nt. (total: 20,915 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FB009_RS08820: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FB009_RS08860: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase aminotransferase kinase sulfotransferase transketolase

FB009_RS08825: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

FB009_RS08840: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

FB009_RS08855: aminotransferase

smcogs: SMCOG1019: aminotransferase

FB009_RS08880: transketolase

smcogs: SMCOG1204: transketolase

FB009_RS08890: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Ligases: synthase synthetase

FB009_RS08850: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

FB009_RS08885: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.58	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000867.3	0.50	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001361.3	0.48	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.48	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0001184.4	0.45	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0000888.5	0.44	other (other)	bacilysin	Bacillus sp. CS93
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.58	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000867.3	0.50	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001361.3	0.48	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.48	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0001184.4	0.45	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0000888.5	0.44	other (other)	bacilysin	Bacillus sp. CS93
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FB009_RS08850: PT_FPPS_like

Domain 1 (42 - 303): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 25.77 out of 29.72

Confidence: strong

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.11 out of 27.18

Confidence: medium

Additional weak hits (11):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.24 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.74 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.62 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.74 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.88 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.49 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.76 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.27 out of 29.38

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.70 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
NrdR	Represses ribonucleotide reductase encoding genes
NtrC	Nitrogen regulatory protein C

NZ_VITA01000006.1 - Region 1 - azole-containing-RiPP

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Location: 278,484 - 305,603 nt. (total: 27,120 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FB009_RS13095: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: sulfhydrylase

FB009_RS13215: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Lyases: hydratase

FB009_RS13195: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

FB009_RS13090: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.53	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000706.3	0.42	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001909.3	0.39	PKS	strobilurin A	Strobilurus tenacellus
BGC0000483.5	0.38	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0000477.3	0.38	ribosomal	patellin 2, patellin 3	uncultured Prochloron sp. 06037A
BGC0000904.5	0.38	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0001215.5	0.38	NRPS	conglobatin	Streptomyces conglobatus
BGC0002246.3	0.37	terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000783.3	0.37	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0002560.3	0.36	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.53	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000706.3	0.42	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001909.3	0.39	PKS	strobilurin A	Strobilurus tenacellus
BGC0000483.5	0.38	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0000477.3	0.38	ribosomal	patellin 2, patellin 3	uncultured Prochloron sp. 06037A
BGC0000904.5	0.38	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0001215.5	0.38	NRPS	conglobatin	Streptomyces conglobatus
BGC0002246.3	0.37	terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000783.3	0.37	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0002560.3	0.36	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (10):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.43 out of 30.25

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.12 out of 27.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.34 out of 27.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.49 out of 39.62

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.91 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.66 out of 29.65

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.32 out of 26.12

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.28 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.78 out of 20.01

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description

Core peptide predictions

No core peptides found.

NZ_VITA01000007.1 - Region 1 - 2dos

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Location: 282,915 - 317,313 nt. (total: 34,399 nt) Show pHMM detection rules used

2dos: ((DOIS or DHQ_synthase or ValA or salQ) and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and ADH_zinc_N)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase aminotransferase transferase

FB009_RS14985: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

FB009_RS15080: aminotransferase

smcogs: SMCOG1019: aminotransferase

FB009_RS15100: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: hydrolase

FB009_RS14960: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

FB009_RS15070: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase

FB009_RS14970: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

FB009_RS15010: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.43	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001485.4	0.42	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002116.3	0.42	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0001534.3	0.41	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001267.3	0.41	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000925.5	0.41	other (other)	quinolobactin	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.43	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001485.4	0.42	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002116.3	0.42	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0001534.3	0.41	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001267.3	0.41	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000925.5	0.41	other (other)	quinolobactin	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.29 out of 25.31

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.59 out of 18.57

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 20.47

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.41 out of 27.55

Confidence: medium

Additional weak hits (7):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.46 out of 21.55

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.48 out of 32.74

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.90 out of 24.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.66 out of 29.25

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.09 out of 20.01

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
GnfM	Regulator of nitrogen-fixation genes
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_VITA01000008.1 - Region 1 - terpene

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Location: 72,249 - 93,091 nt. (total: 20,843 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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other genes

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binding site

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Select a gene to view the details available for it

Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	terpene	Similarity score	Type	Compound(s)	Organism
BGC0002120.3		0.25	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000698.5		0.18	saccharide	hygromycin A	Streptomyces hygroscopicus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0002120.3		0.25	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000698.5		0.18	saccharide	hygromycin A	Streptomyces hygroscopicus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

FB009_RS15710: PT_phytoene_like

Domain 1 (12 - 277): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.74 out of 25.88

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

Additional weak hits (1):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.70 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
PsrA	Oleic acid responsive regulator

NZ_VITA01000010.1 - Region 1 - redox-cofactor

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Location: 1,968 - 24,155 nt. (total: 22,188 nt) Show pHMM detection rules used

Region on contig edge.

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FB009_RS17830: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: transketolase

FB009_RS17780: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: hydrolase

FB009_RS17845: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002571.2	0.43	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002404.2	0.41	other (other)	falcarindiol	Solanum lycopersicum
BGC0002575.2	0.41	ribosomal	cochonodin I	Streptococcus suis
BGC0000043.5	0.39	PKS	curacin A	Moorea producens 19L
BGC0002514.3	0.38	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0002012.4	0.37	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0002181.3	0.37	terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0000252.5	0.37	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0001605.3	0.37	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002000.4	0.37	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002571.2	0.43	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002404.2	0.41	other (other)	falcarindiol	Solanum lycopersicum
BGC0002575.2	0.41	ribosomal	cochonodin I	Streptococcus suis
BGC0000043.5	0.39	PKS	curacin A	Moorea producens 19L
BGC0002514.3	0.38	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0002012.4	0.37	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0002181.3	0.37	terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0000252.5	0.37	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0001605.3	0.37	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002000.4	0.37	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

Additional weak hits (4):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.38 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.98 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.10 out of 26.06

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.53 out of 23.43

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 7 - 95; Score: 93.9; RRE type: Thurincin_rSAM_RRE; Location: 34 - 89; Score: 27.1

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_VITA01000011.1 - Region 1 - hserlactone

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Location: 160,861 - 181,505 nt. (total: 20,645 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FB009_RS19640: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: hydratase

FB009_RS19655: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Isomerases: racemase

FB009_RS19600: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0000584.5	0.40	ribosomal	colicin V	Escherichia coli
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000589.5	0.39	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000588.5	0.39	ribosomal	microcin L	Escherichia coli
BGC0000561.5	0.39	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000587.5	0.39	ribosomal	microcin H47	Escherichia coli
BGC0000498.5	0.38	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0001684.3	0.38	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000188.5	0.38	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0000584.5	0.40	ribosomal	colicin V	Escherichia coli
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000589.5	0.39	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000588.5	0.39	ribosomal	microcin L	Escherichia coli
BGC0000561.5	0.39	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000587.5	0.39	ribosomal	microcin H47	Escherichia coli
BGC0000498.5	0.38	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0001684.3	0.38	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000188.5	0.38	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (10):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.55 out of 27.78

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.46 out of 32.74

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.58 out of 30.22

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.27 out of 32.74

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.75 out of 26.12

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.27 out of 30.97

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.00 out of 27.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.81 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.76 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production

NZ_VITA01000012.1 - Region 1 - thioamitides

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Location: 53,947 - 75,960 nt. (total: 22,014 nt) Show pHMM detection rules used

thioamitides: ((YcaO or TIGR03604) and TfuA)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

FB009_RS20160: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001849.4	0.45	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0002560.3	0.45	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0000625.5	0.41	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0001802.5	0.40	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.40	ribosomal	neothioviridamide	Streptomyces sp.
BGC0002669.2	0.38	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002120.3	0.31	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000544.4	0.31	ribosomal	planosporicin	Planomonospora alba
BGC0001510.5	0.28	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0001797.3	0.27	ribosomal	telomestatin	Streptomyces anulatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001849.4	0.45	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0002560.3	0.45	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0000625.5	0.41	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0001802.5	0.40	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.40	ribosomal	neothioviridamide	Streptomyces sp.
BGC0002669.2	0.38	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002120.3	0.31	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000544.4	0.31	ribosomal	planosporicin	Planomonospora alba
BGC0001510.5	0.28	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0001797.3	0.27	ribosomal	telomestatin	Streptomyces anulatus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.02 out of 25.31

Confidence: medium

Additional weak hits (7):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.89 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.33 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.70 out of 20.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.67 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
MexT	Global virulence regulator

NZ_VITA01000013.1 - Region 1 - T1PKS

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Location: 1 - 32,960 nt. (total: 32,960 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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binding site

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Gene details

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Gene overview

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SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FB009_RS20895: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FB009_RS20905: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Ligases: synthase

FB009_RS20900: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000037.4	0.59	PKS	cichorine	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000037.4	0.59	PKS	cichorine	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.48 out of 28.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.03 out of 30.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.64 out of 29.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.67 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 32960:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FB009_RS20905: mal

PKS_AT (527..824): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Propionyl-CoA: 62.5%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.3
Methoxymalonyl-CoA: 80.0
Methylmalonyl-CoA: 79.7
Ethylmalonyl-CoA: 47.4
Propionyl-CoA: 37.1
trans-1,2-CPDA: 35.1
3-Methylbutyryl-CoA: 29.0
inactive: 25.9
Isobutyryl-CoA: 21.1
2-Methylbutyryl-CoA: 19.4
fatty_acid: 18.6
CHC-CoA: 12.9
Acetyl-CoA: 7.5
Benzoyl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_VITA01000016.1 - Region 1 - arylpolyene

Download region GenBank file

Download region SVG

Location: 30,530 - 71,732 nt. (total: 41,203 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

FB009_RS23630: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

FB009_RS23635: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

FB009_RS23685: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

FB009_RS23715: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase

FB009_RS23750: aminotransferase

smcogs: SMCOG1019: aminotransferase

Ligases: synthase

FB009_RS23720: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FB009_RS23725: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transporter

FB009_RS23665: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002000.4	0.44	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002487.3	0.44	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002488.3	0.44	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002656.2	0.44	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0000196.4	0.44	PKS	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002711.2	0.43	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000254.5	0.43	PKS	oxytetracycline	Streptomyces rimosus
BGC0000264.5	0.43	PKS	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0002510.2	0.43	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002000.4	0.44	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002487.3	0.44	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002488.3	0.44	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002656.2	0.44	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0000196.4	0.44	PKS	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002711.2	0.43	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000254.5	0.43	PKS	oxytetracycline	Streptomyces rimosus
BGC0000264.5	0.43	PKS	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0002510.2	0.43	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 23.22 out of 27.55

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 24.74 out of 26.33

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 28.19

Confidence: medium

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.13 out of 26.06

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.90 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.55 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.59 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.25 out of 36.53

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.70 out of 32.93

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_VITA01000026.1 - Region 1 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 1 - 23,182 nt. (total: 23,182 nt) Show pHMM detection rules used

Region on contig edge.

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

FB009_RS28775: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000565.5	0.48	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000483.5	0.46	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0002551.2	0.46	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0002485.2	0.45	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906
BGC0002584.2	0.45	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0001849.4	0.44	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0000480.5	0.42	ribosomal	tenuecyclamide A, tenuecyclamide C	Nostoc spongiaeforme var. tenue str. Carmeli
BGC0000475.5	0.42	ribosomal	patellamide A, patellamide C	Prochloron didemni
BGC0002488.3	0.42	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0000471.4	0.42	ribosomal	viridisamide A	Oscillatoria nigro-viridis PCC 7112

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000565.5	0.48	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000483.5	0.46	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0002551.2	0.46	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0002485.2	0.45	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906
BGC0002584.2	0.45	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0001849.4	0.44	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0000480.5	0.42	ribosomal	tenuecyclamide A, tenuecyclamide C	Nostoc spongiaeforme var. tenue str. Carmeli
BGC0000475.5	0.42	ribosomal	patellamide A, patellamide C	Prochloron didemni
BGC0002488.3	0.42	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0000471.4	0.42	ribosomal	viridisamide A	Oscillatoria nigro-viridis PCC 7112

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

Additional weak hits (9):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.14 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.84 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.82 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.93 out of 29.38

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.78 out of 21.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.79 out of 27.78

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

Core peptide predictions

No core peptides found.

NZ_VITA01000039.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 13,408 nt. (total: 13,408 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

FB009_RS31295: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002699.2	0.38	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002110.3	0.34	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001867.2	0.30	ribosomal	prochlorosins	Prochlorococcus marinus str. MIT 9313
BGC0001687.3	0.29	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0002711.2	0.26	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002560.3	0.24	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0001053.5	0.21	NRPS, PKS	tubulysin A	Archangium disciforme

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002699.2	0.38	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002110.3	0.34	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001867.2	0.30	ribosomal	prochlorosins	Prochlorococcus marinus str. MIT 9313
BGC0001687.3	0.29	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0002711.2	0.26	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002560.3	0.24	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0001053.5	0.21	NRPS, PKS	tubulysin A	Archangium disciforme

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FB009_RS31295

allorf_06616_06849

Leader:

MMVVYLRASPSAAYQRINSCQPIRDNESAIS

Core:

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

Core with dehydrations:

YLDhaEVAERLNKQLIKVQGENMVDhbKDhaLIKRLMMLVCysPPDhaRRVPPGLG

antiSMASH-DB 4.0 matches for allorf_06616_06849

100.0%

NC_009621.1and 4 others:

NZ_CP088111.1 Lanthipeptides: allorf_0786726_0786959_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_6661_6894_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1862_2095_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_06616_06849_lanthipeptide

Lanthipeptides: allorf_1020482_1020715_lanthipeptide

1

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

46

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

1

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

46

19.6%

NZ_FMHJ01000003.1:

Lanthipeptides: allorf_516193_516348_lanthipeptide

23

TKSLIKRLMMLVCP--PSRRVPPG

44

++ KRL +C P RR P G

5

SRGRGKRLRNALCGGWPGRRAPQG

28

17.4%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide

Lanthipeptides: GVO03_RS04860_lanthipeptide

17

QGENMVTKSLIKRLMMLVC

35

+GEN+ T L+K + L C

10

KGENVTTDILLKICIALDC

28

with 1 more sequence matches

12.5%

NZ_CP086102.1and 1 other:

NZ_KZ195572.1 Lanthipeptides: allorf_6138327_6138542_lanthipeptide

Lanthipeptides: allorf_6127439_6127654_lanthipeptide

27

IKRLMMLVCPPSR

39

+RL M +CP R

21

ARRLFMCLCPHCR

33

allorf_07280_07351

Leader:

MVASAGG

Core:

FPAPARSAEPADVHNC

Core with dehydrations:

FPAPARDhaAEPADVHNCys

antiSMASH-DB 4.0 matches for allorf_07280_07351

100.0%

NC_009621.1and 6 others:

NC_017327.1 Lanthipeptides: allorf_0124171_0124311_lanthipeptideNZ_CP021217.1 Lanthipeptides: allorf_1159796_1159936_lanthipeptideNZ_CP088111.1 Lanthipeptides: allorf_0786224_0786295_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_7325_7396_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1360_1431_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_07280_07351_lanthipeptide

Lanthipeptides: allorf_1019980_1020051_lanthipeptide

1

FPAPARSAEPADVHNC

16

FPAPARSAEPADVHNC

1

FPAPARSAEPADVHNC

16

43.8%

NZ_CP077072.1:

Lanthipeptides: allorf_2549811_2549951_lanthipeptide

3

APARSAEPAD

12

AP R AEP D

6

APPRHAEPHD

15

allorf_07780_07926

Leader:

MQPTSLGG

Core:

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

Core with dehydrations:

PRPLHFILVDCysAPVANPDhbYVEADLRADhbMKHDQFMCysFAIHV

antiSMASH-DB 4.0 matches for allorf_07780_07926

100.0%

NC_009621.1and 4 others:

NZ_CP088111.1 Lanthipeptides: allorf_0785650_0785796_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_7824_7970_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_0786_0932_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_07780_07926_lanthipeptide

Lanthipeptides: allorf_1019406_1019552_lanthipeptide

1

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

40

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

1

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

40

97.5%

NC_017327.1and 1 other:

NZ_CP021217.1 Lanthipeptides: allorf_1159245_1159391_lanthipeptide

Lanthipeptides: allorf_0124716_0124862_lanthipeptide

1

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

40

PRPLHFILVDCAPVANPTYV+ADLRATMKHDQFMCFAIHV

1

PRPLHFILVDCAPVANPTYVDADLRATMKHDQFMCFAIHV

40

20.0%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

15

ANPTYVEADLRATMK

29

A PT VEA + AT+

10

ATPTIVEATIAATVS

24

with 4 more sequence matches

20.0%

NZ_CP059734.1:

Lanthipeptides: allorf_0384683_0384871_lanthipeptide

4

LHFILVDCAPVANP

17

LH + C PVANP

1

LHIYFLTCQPVANP

14

17.5%

NZ_CP012109.1:

Lanthipeptides: allorf_7979331_7979543_lanthipeptide

1

PRPLHFILVDCAP

13

PRP +L DC P

14

PRPARALLRDCRP

26

17.5%

NZ_FONG01000023.1:

Lanthipeptides: allorf_088862_088996_lanthipeptide

10

DCAPVANPTYVEADLRA

26

D AP PT +LR

7

DAAPPTQPTRRRPELRG

23

12.5%

NZ_VIKW01000003.1:

Lanthipeptides: FJR04_RS03310_lanthipeptide

3

PLHFILVDCAPVA

15

P H + V C P+

7

PFHTLWVGCKPIG

19

allorf_07910_08014

Leader:

MRYMYEATYARLCPSSSTISKIYLKQITGS

Core:

NCTI

Core with dehydrations:

NCysDhbI

allorf_11237_11311

Leader:

MLRSSSAGA

Core:

ALCAATAATSTTLPL

Core with dehydrations:

ALCysAADhbAADhbDhaDhbDhbLPL

allorf_11609_11731

Leader:

MSRDDRFATILAS

Core:

ASHSCERRRGFMLSKVERRRIFCLKPS

Core with dehydrations:

ADhaHDhaCysERRRGFMLDhaKVERRRIFCysLKPDha

antiSMASH-DB 4.0 matches for allorf_11609_11731

100.0%

NC_009621.1and 2 others:

NZ_CP088111.1 Lanthipeptides: allorf_0781849_0781971_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_11609_11731_lanthipeptide

Lanthipeptides: allorf_1015605_1015727_lanthipeptide

1

ASHSCERRRGFMLSKVERRRIFCLKPS

27

ASHSCERRRGFMLSKVERRRIFCLKPS

1

ASHSCERRRGFMLSKVERRRIFCLKPS

27

22.2%

NZ_CP059997.1:

Lanthipeptides: allorf_02572182_02572382_lanthipeptide

1

ASHSCERRRGFMLSK

15

A C RR GF+ +

8

AYSPCARRPGFLTGQ

22

22.2%

NZ_QGTL01000006.1:

Lanthipeptides: allorf_313739_313885_lanthipeptide

1

ASHSCERRRG

10

A+ +C RRRG

12

AAQACARRRG

21

with 1 more sequence matches

12.3%

NZ_CP059318.1:

Lanthipeptides: allorf_0101772_0101999_lanthipeptide

4

SCERRRGFMLSKVERRR

20

S + RGF+ +V RR+

19

SADGSRGFLPVRVGRRQ

35

MIBiG 4.0 matches for allorf_11609_11731

18.5%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

4

SCERRRGFMLS

14

SC GF S

1

SCNCVCGFCCS

11

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (2):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.25 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.88 out of 26.06

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

allorf_06616_06849 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 5118.9 Da

Molecular weight: 5122.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5140.2 Da N = 1; 5158.2 Da N = 2; 5176.2 Da N = 3

allorf_07280_07351 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 1662.8 Da

Molecular weight: 1663.8 Da

Number of bridges: 1

allorf_07780_07926 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 4529.3 Da

Molecular weight: 4532.3 Da

Number of bridges: 2

allorf_07910_08014 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 431.2 Da

Molecular weight: 431.5 Da

Number of bridges: 1

allorf_11237_11311 - Class II

Cleavage pHMM score: -3.50

RODEO score: 0

Monoisotopic mass: 1313.7 Da

Molecular weight: 1314.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1332.5 Da N = 1; 1350.6 Da N = 2; 1368.6 Da N = 3; 1386.6 Da N = 4

allorf_11609_11731 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 3176.7 Da

Molecular weight: 3178.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3196.8 Da N = 1; 3214.8 Da N = 2

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_VITA01000048.1 - Region 1 - thioamitides

Download region GenBank file

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Location: 1 - 10,892 nt. (total: 10,892 nt) Show pHMM detection rules used

Region on contig edge.

thioamitides: ((YcaO or TIGR03604) and TfuA)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

FB009_RS32095: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.49	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0002560.3	0.49	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0001802.5	0.45	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.45	ribosomal	neothioviridamide	Streptomyces sp.
BGC0000625.5	0.42	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0002669.2	0.41	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001474.4	0.41	ribosomal	thiopeptin	Streptomyces tateyamensis
BGC0002120.3	0.39	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0001473.4	0.39	ribosomal	Sch 18640	Micromonospora arborensis
BGC0000925.5	0.38	other (other)	quinolobactin	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.49	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0002560.3	0.49	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0001802.5	0.45	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.45	ribosomal	neothioviridamide	Streptomyces sp.
BGC0000625.5	0.42	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0002669.2	0.41	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001474.4	0.41	ribosomal	thiopeptin	Streptomyces tateyamensis
BGC0002120.3	0.39	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0001473.4	0.39	ribosomal	Sch 18640	Micromonospora arborensis
BGC0000925.5	0.38	other (other)	quinolobactin	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.64 out of 25.31

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.77 out of 28.19

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.64 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.64 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.64 out of 25.31

Confidence: medium

Additional weak hits (1):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.64 out of 29.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
ZuR variant 1	Zinc-responsive repressor