LOCUS       NZ_AP019791            24245 bp    DNA     circular CON 25-APR-2024
DEFINITION  Rubrobacter xylanophilus strain AA3-22 chromosome, complete genome.
ACCESSION   NZ_AP019791
VERSION     NZ_AP019791.1
KEYWORDS    RefSeq.
SOURCE      Rubrobacter xylanophilus
  ORGANISM  Rubrobacter xylanophilus
            Bacteria; Actinomycetota; Rubrobacteria; Rubrobacterales;
            Rubrobacteraceae; Rubrobacter.
REFERENCE   1
  AUTHORS   Tomariguchi,N. and Miyazaki,K.
  TITLE     Complete Genome Sequence of Rubrobacter xylanophilus Strain AA3-22,
            Isolated from Arima Onsen in Japan
  JOURNAL   Microbiol Resour Announc 8 (34), e00818-19 (2019)
   PUBMED   31439702
  REMARK    DOI:10.1128/MRA.00818-19 Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3022875)
  AUTHORS   Miyazaki,K. and Tomariguchi,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2019) Contact:Kentaro Miyazaki National Institute
            of Advanced Industrial Science and Technology; 1-1-1 Higashi,
            Tsukuba 305-8566, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.4
            Genome Coverage                   :: 758x
            Sequencing Technology             :: NovaSeq6000; GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007164525.1-RS_2024_04_25
            Annotation Date                   :: 04/25/2024 02:58:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,085
            CDSs (total)                      :: 3,032
            Genes (coding)                    :: 3,015
            CDSs (with protein)               :: 3,015
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 17
            CDSs (without protein)            :: 17
            Pseudo Genes (ambiguous residues) :: 0 of 17
            Pseudo Genes (frameshifted)       :: 5 of 17
            Pseudo Genes (incomplete)         :: 9 of 17
            Pseudo Genes (internal stop)      :: 4 of 17
            Pseudo Genes (multiple problems)  :: 1 of 17
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:10:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 826342
            Orig. end                         :: 850587
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP019791.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated at DFAST https://dfast.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24245
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="4"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..24245
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24245
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:14245](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14245)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(70..720)
                     /locus_tag="RxyAA322_RS04335"
                     /old_locus_tag="RxyAA322_08610"
     CDS             complement(70..720)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564529.1"
                     /locus_tag="RxyAA322_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08610"
                     /product="response regulator transcription factor"
                     /protein_id="WP_197735544.1"
                     /transl_table=11
                     /translation="MSGPVRVMIVEDQALMREGLRTLLDLEEGVEVVGEAADGVEALER
                     LPGARPEVVLVDVRMPRMDGIELIERLRREHPEVAAIILTTFDDDDYVFRGLRAGARGY
                     ILKDTPSEELAAAIEKVHRGEAVLDGPITLKVISELGRLSKEPAGPGPLSEREMEVLRL
                     VASGASNREIARSLYITEGTVKNHISSILRKLGFRDRTQAALYAVERGWMEEP"
     gene            complement(717..2015)
                     /locus_tag="RxyAA322_RS15990"
                     /old_locus_tag="RxyAA322_08620"
     CDS             complement(717..2015)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="RxyAA322_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08620"
                     /product="sensor histidine kinase"
                     /protein_id="WP_172620675.1"
                     /transl_table=11
                     /translation="MIPTEGLLERCCLRKAGMRAKVKGWTYTRTGRNDPGGWFARVGPE
                     GRRGALLMRAVGFSYVGATYVLYLSGEREFGVLPVTAAFLAAAFLMRVMPWERDEAVGV
                     RLLTIPAFALVSFLIIRMTGFGLTTGFLYAAVANGVFVFGFRWGMAYAGFIVLLLFGDL
                     LWMYPQKGVLWALEQAASWSWPLAFVIGICTLAVEAMKQQIHAQELLAELEDAHAELRR
                     YAERARELAVSEERNRIAREIHDSVGHHLTVVNVQLEAAGKLLARDPGRAAEAVARAKA
                     SASEALSEARRAVRALRPPSMGRRAGLRFLDDLVREFHGSGVVVSFEVTGEEHPLPSEV
                     EFVLYRVLQEGLTNALKHSGADRVEVRLELCGETVRLSVTDDGRGASGGTSGGFGLEGL
                     RERVEEVGGRISAGGACGGGFALEVELPAGVGA"
     gene            complement(2107..2259)
                     /locus_tag="RxyAA322_RS15415"
                     /old_locus_tag="RxyAA322_08630"
     CDS             complement(2107..2259)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RxyAA322_RS15415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RxyAA322_08630"
                     /product="hypothetical protein"
                     /protein_id="WP_172620676.1"
                     /transl_table=11
                     /translation="MPWGSTEGFIQAIYRTGTNAYDEKTLAVVRRWRGACAASALSPGT
                     RKAWV"
     tRNA            complement(2356..2428)
                     /anticodon=(pos:complement(828735..828737),aa:His,seq:gtg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="RxyAA322_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="RxyAA322_t00170"
                     /product="tRNA-His"
     gene            complement(2356..2428)
                     /locus_tag="RxyAA322_RS04345"
                     /old_locus_tag="RxyAA322_t00170"
     gene            complement(2485..3681)
                     /locus_tag="RxyAA322_RS04350"
                     /old_locus_tag="RxyAA322_08640"
     CDS             complement(2485..3681)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564542.1"
                     /locus_tag="RxyAA322_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08640"
                     /product="MFS transporter"
                     /protein_id="WP_143527086.1"
                     /transl_table=11
                     /translation="MKGSGVVRVALWFSCVVLAGLNLRASITSVGPVIEGIREDLGLSG
                     GLAGLLTTLPLLAFAAVSPFAPRLAARIGLTRALFGGLVLLAAGIALRSLPHVAALFAG
                     TAILGTAIAAANVLLPGFVKRYFPRRVGLATGAYITAMNVGAALGAGLSVPVARAAGLG
                     WQGALGIWAALALLAAVVWVPLLGERPEGGSSGGGVRLLQGLWRSALAWQVTLFMGLQS
                     IVFYVSITWLPAILRDGGLDAAGAGVMVSLMQVVGIPATLLVPILAARMRSQSALAAGA
                     AVLSGSGILGLMFFGGMLSAVPVFLLGLGQGAAISLALTLFALRAPDAAGAAALSGMAQ
                     TVGYLLAAAGPPLFGALHDLTGGWALPLALLLGITACMLLSGVGAGRNVLVELPAHRS"
     gene            complement(3706..4884)
                     /locus_tag="RxyAA322_RS04355"
                     /old_locus_tag="RxyAA322_08650"
     CDS             complement(3706..4884)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564543.1"
                     /locus_tag="RxyAA322_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08650"
                     /product="4-hydroxybenzoate 3-monooxygenase"
                     /protein_id="WP_143527087.1"
                     /transl_table=11
                     /translation="MRTQVGIVGGGPAGLLLAHLLHLRGVESVVLERRSREELESEIRA
                     GVLEQGTVDLLNEIGVGERMMKEGAFHRGVNLQFGGRRHRIDFQDLVGRGIMLYGQHEV
                     VKDLISARLASGGEIVFEAQALAVEGADTESPVVRYADRSGREEELSCDFVAGCDGFHG
                     VCRPSIPETARREYERHYPFGWFGILVEAPRSSEELIYCLHERGFALISTRSPQIQRMY
                     LQCDPDDDVANWPDERVWEELHARLAMAEDGWRLKEGPILQKNIVAMRSFICEPMRYGR
                     LFLAGDAAHIVPPTGAKGMNLAVADVRVLCEAITGFYASGRTDLLDAYSERCLRRVWKA
                     QRFSWWMTSMLHRFHGEDEFRYRLQLAELDYVTGSRAASTSLAENYTGLPME"
     gene            complement(5050..6423)
                     /locus_tag="RxyAA322_RS04360"
                     /old_locus_tag="RxyAA322_08660"
     CDS             complement(5050..6423)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564544.1"
                     /locus_tag="RxyAA322_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08660"
                     /product="aminomethyl transferase family protein"
                     /protein_id="WP_143527088.1"
                     /transl_table=11
                     /translation="MSRRSLEDLLAGARSPVELLRNSQIGPYAFPGVPAEFTNWRDEQR
                     AWRESCVLFDQSYHMTDLYIEGPDVKRLLSDLGINSFEGFKKNNAKQFVACNPDGYVIG
                     DAVLFGLEDDRVSLVGRPTAHNWVQYHAENGDYDVKVERDERYAVNPEKRRRLYRYQIQ
                     GPNAGELLEKLNGGPLPQVPFFNMYEINIGGRKVRALRHGMSGQPGAEIFGPWEERDEI
                     KGIIIEAGEEYGLKQVGSRTYATNTLESGWIPSPCPAIYTGEQMKPYREWLPANGYEAM
                     ASLGGSFYSERIEDYYFTPYELGYGRFVKFDHDFVGREALEEMAEGPHRRKVTLVWEGE
                     DVKEVFASLFEREGLPAKYIDLPLSNYATLPYDRVEKDGRVVGVSTYTGYSYNERSMLS
                     LAVVDEEVAEPGSEVVLLWGEEPNSSKPTVEEHRQVEIRATVQPAPLVEFARTAYRRS"
     gene            complement(6529..7497)
                     /locus_tag="RxyAA322_RS04365"
                     /old_locus_tag="RxyAA322_08670"
     CDS             complement(6529..7497)
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011565448.1"
                     /locus_tag="RxyAA322_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08670"
                     /product="tetrahydrofolate dehydrogenase/cyclohydrolase
                     catalytic domain-containing protein"
                     /protein_id="WP_143527089.1"
                     /transl_table=11
                     /translation="MGARVIDGRALAEELKLRVISEVEELAAGGVRPGLATVFVGEDYA
                     ARAYERRVRKLAGELGCRYTCERLPEEAEEADVLAVVGKLNADPRVSGILVLRPLPERV
                     SEPAVYRMLDPLKDIEAVHPVNAGLLALGRPRYVPSTPAACFYLLDRYLKLSGRDPEEY
                     YRSSTVVVVGRSNNVGKPAVSLGFARGATVISCDVNTYRAGRLREQTVRADVLIVAAGV
                     AGLIDESYVREGVIAVDVGINPVADPEGGGRTILVGDLDFQSVARKAEALTPVPGGVGP
                     ITDVWLLKNTAAAARWSSSRFPGRRWLPVAAPAISGGYEEQ"
     misc_feature    7452..7466
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            complement(7503..8087)
                     /locus_tag="RxyAA322_RS04370"
                     /old_locus_tag="RxyAA322_08680"
     CDS             complement(7503..8087)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564546.1"
                     /locus_tag="RxyAA322_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08680"
                     /product="cyclodeaminase/cyclohydrolase family protein"
                     /protein_id="WP_244299854.1"
                     /transl_table=11
                     /translation="MSGTSGAPDYLRMPLGRFLEALASGESAPGGGGAAAVALALAAGL
                     AGMAARLSPEHLEEAGTLAREADQLREEVAPLAQADAEAFGRVLAAYRLPRGREGREER
                     IREALEEAAAVPLEMARVGTRVARIASRLVREGNPNLKGDAVAAVLLAEAGVRVAAELV
                     RANEPEGEKARRVERFVEEAFREREALEGGG"
     gene            complement(8084..9820)
                     /locus_tag="RxyAA322_RS04375"
                     /old_locus_tag="RxyAA322_08690"
     CDS             complement(8084..9820)
                     /EC_number="6.3.4.3"
                     /GO_function="GO:0004329 - formate-tetrahydrofolate ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011565449.1"
                     /locus_tag="RxyAA322_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08690"
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="WP_143527090.1"
                     /transl_table=11
                     /translation="MSTGSVPSNIEIARGAKLLPIGEVARSMGIEREELIEPYGEGVGK
                     IKLEAMEELGGRPRARYVLVSAITPTPLGEGKTTTTVGLGQAFSHIGRRATIAIRQASM
                     GPAFGIKGGAAGGGYSQVVPMERLNLHLTGDLHAVTEAHNMLSAMLDNHLYQGNSLGID
                     PHSISWRRVMDVNDRSLRNIVIGLGGRVDGIPRQSGFDITAASEVMAILALCTSLEDLR
                     ERLGRIVVGVDKEGRPISAEDLKAAGAMAVILKEAVKPNLMQTLEGTPALVHAGPFGNI
                     ATGNSSVVADLIGIHCGDYLITEAGFGADMGAERFFNIKCRISGLKPDAAVVVSTVRAL
                     KAHSGRYQIKAGAPLPEELLKENPEDVLAGAENLKKQLENIKLHGVPAVVAINAFPTDH
                     PSEHRAIEEVAREAGARAAVCHHFLKGGKGAVELAEALEETIEENEKEKRGGQSSSFRF
                     LYPLEAPLKQKIETIATEVYGAQGVEYDQEAARQLEEYEKAGFGRLPVCIAKTHLSISS
                     DPALKGAPRGWKLPVREVRASVGAGFIYPICGQMRTMPGLSAHPAAEGIDLDEAGNVVG
                     LF"
     misc_feature    complement(8423..8425)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8741..8743)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9158..9160)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9867..9884)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    complement(9917..9930)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.52"
                     /tool="antismash"
     misc_feature    complement(9923..9940)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.06"
                     /tool="antismash"
     gene            complement(10001..11983)
                     /locus_tag="RxyAA322_RS04380"
                     /old_locus_tag="RxyAA322_08700"
     CDS             complement(10001..11983)
                     /EC_number="6.2.1.16"
                     /GO_function="GO:0030729 - acetoacetate-CoA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (115-526). E-value: 9.3e-60.
                     Score: 194.2. Matches aSDomain:
                     nrpspksdomains_RxyAA322_RS04380_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564548.1"
                     /locus_tag="RxyAA322_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08700"
                     /product="acetoacetate--CoA ligase"
                     /protein_id="WP_143527091.1"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-68, bitscore:
                     227.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTGEVLWTPPSDVLETTEIGRYVRWLREERGLKFEGYDELWRW
                     SVGDLEAFWRSVWDFYGVRAHTPPERVLAAREMPGARWFPGARLNYAERILTPSDDDEE
                     VAIFAHSQTRAPFELTFGELREQVARARAGLRRLGVGPGDRVAAYLPNVPETVVAFLAT
                     ASLGAIWATCAPEFGPRSVIDRFGQLDPKVLLAVTGYRYGEKHIDRRAEVRDIRRALPT
                     LEHVVHVPYVGGAEDVLPDSVGWEELLSEEEPLRCEPVPFDHPLYVLFSSGTTGKPKAI
                     VHGHGGILLEHLKNLGLTWDLRPGSRLMWFTTTAWMMWNALVSALLLRSAIVTMDGNPL
                     YPDLAFQWRLAEQTGATMLGVAPAFLMACRKAGLEVGREFDLSSVRQIGAAGSPLPPEG
                     FDWVYEQLGPDVLLNIGSGGTDVCTGIVQGSPLQPVYRGEISGPCLGVDAAAYDERGRP
                     VVGEFGELVIRSPMPSMPLGFWNDPGDRRYRAAYFERFPGVWCHGDWIRFTERGSCVIS
                     GRSDATLNRGGVRLGTGEIYAVVESFEEVADSLVVHLEDAEGGPGELLLFVVPAPGTEL
                     DESLRSRIAATLRRELSPRHVPDTIEAVSSIPRTLSQKKLEVPVKRILRGARPEEVASR
                     DSLLDPAALDAFAAYAASRRHPHDA"
     aSDomain        complement(10406..11638)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RxyAA322_RS04380_AMP-binding.1"
                     /evalue="9.30E-60"
                     /label="RxyAA322_RS04380_AMP-binding.1"
                     /locus_tag="RxyAA322_RS04380"
                     /protein_end="526"
                     /protein_start="115"
                     /score="194.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="PFELTFGELREQVARARAGLRRLGVGPGDRVAAYLPNVPETVVAF
                     LATASLGAIWATCAPEFGPRSVIDRFGQLDPKVLLAVTGYRYGEKHIDRRAEVRDIRRA
                     LPTLEHVVHVPYVGGAEDVLPDSVGWEELLSEEEPLRCEPVPFDHPLYVLFSSGTTGKP
                     KAIVHGHGGILLEHLKNLGLTWDLRPGSRLMWFTTTAWMMWNALVSALLLRSAIVTMDG
                     NPLYPDLAFQWRLAEQTGATMLGVAPAFLMACRKAGLEVGREFDLSSVRQIGAAGSPLP
                     PEGFDWVYEQLGPDVLLNIGSGGTDVCTGIVQGSPLQPVYRGEISGPCLGVDAAAYDER
                     GRPVVGEFGELVIRSPMPSMPLGFWNDPGDRRYRAAYFERFPGVWCHGDWIRFTERGSC
                     VISGRSDATLNR"
     CDS_motif       complement(11129..11185)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RxyAA322_RS04380_0001"
                     /evalue="2.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="RxyAA322_RS04380"
                     /protein_end="285"
                     /protein_start="266"
                     /score="20.3"
                     /tool="antismash"
                     /translation="YVLFSSGTTGKPKAIVHGH"
     gene            complement(11974..12789)
                     /locus_tag="RxyAA322_RS04385"
                     /old_locus_tag="RxyAA322_08710"
     CDS             complement(11974..12789)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024740.4"
                     /locus_tag="RxyAA322_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08710"
                     /product="HAD hydrolase-like protein"
                     /protein_id="WP_143527092.1"
                     /transl_table=11
                     /translation="MSGAKKLERIRGFVFDVDGSLVHRDAGFHPRPLPGAPEVLEKIRT
                     SGRPLVLFTNGTHLRPEEFARGLREGGLPVRDDEVLTPVCSALGYLARRHGGRRTMVFG
                     SETTRERMAEAGVPLTDGEDAEVVFVTHVNEVDFDSLERAARAITRGAPLLTASYGPGY
                     WGANGMIFSRGAMVTAALVKATGKRPIVVGKPSRMAVRAACERLGVESREMAVIGDDLD
                     MDIGLGRLGGSFTILVRSGTSGSVDLQRVPERRRPDAVVEGVGEILKWL"
     gene            complement(12767..14245)
                     /locus_tag="RxyAA322_RS04390"
                     /old_locus_tag="RxyAA322_08720"
     CDS             complement(12767..14245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564550.1"
                     /locus_tag="RxyAA322_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08720"
                     /product="biotin carboxyl carrier protein"
                     /protein_id="WP_143527093.1"
                     /sec_met_domain="HMGL-like (E-value: 1.2e-26, bitscore:
                     91.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTVEIVDTTIRDGNQSLWSATGLTTQDVLAIAPTMDRVGFHAL
                     DFTSSTHMAVSVRFHREDPWERIRLVSAAMPNTPLGLITTGMRFIRWVPAGEDVMRLAF
                     RCWVRNGMRRIQIVDPSNQPEALLRMARVAREEGFEEVVVGLTYSISPVHTHDYYLERA
                     EAVSRSEDIDRLYLKDPGGLLMPEAVRTLIPGFIERFAPRPVELHSHCTIGLGPLAYVE
                     GLRSGVRTLHTAVEPLGSGSSNPPAKSTLRNVEAEGLSYDLDTEALEAVSEYFDELARE
                     RGLPPGSPREFDGAYFRHQMPGGMISTTRRQLQELGRPELFDAVLEEVPRVRAEMGYPI
                     MVTPVSQFVATQAVMNVISGERWSRVSDEMVRYFLGHYYETPAPVDPEVADRVLSTPRA
                     SELKDLEPISLDGARERFGRRISDEELLLRLTMPAEQVDAMVAERGRPRAPLVRPGRAP
                     VVRLLHELSRRDSISYLRLEDERTGDTIVWRKEA"
     gene            complement(14242..15582)
                     /locus_tag="RxyAA322_RS04395"
                     /old_locus_tag="RxyAA322_08730"
     CDS             complement(14242..15582)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011563035.1"
                     /locus_tag="RxyAA322_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08730"
                     /product="biotin carboxylase N-terminal domain-containing
                     protein"
                     /protein_id="WP_244299914.1"
                     /sec_met_domain="ATP-grasp (E-value: 7.9e-07, bitscore:
                     26.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.3e-09,
                     bitscore: 34.6, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVFVANRGEIAVRVVRSCRELGLETVVGFSEADRGSLAARMAD
                     RAVCIGPGSPAQSYLNVGAVVQAAIGTGCDAIHPGYGFLSENPALAAAACENGLRFVGP
                     PAEVIELAGDKLRSREVAAEAGLPVVPGGEVSALADALRFAEEAGYPVLLKAAAGGGGR
                     GIKLARDREELERLFGVALAEAGAAFGDERLYVERFIRSARHVEVQVAADEHGGVLHFG
                     ERDCSVQRRYQKIVEEAPAPGLDAGTRAALHGAAVAFAREIGYRNLGTVEFVVDAESGE
                     FFFMEMNCRIQVEHPVTEAVTGRDLVADQLRIAADERLGLSQEEVEFRGHAIECRLTAE
                     DPAHGFRPTPGRISRFSVPEIEGLRVDTHCEEGTLVPPYYDSLLAKLVSCAGDREGAIE
                     RMREALEGLVVEGVPTNRELLMHVLAHPDFTGAAVDTTWLEEAVLAA"
     gene            complement(15585..16079)
                     /gene="accB"
                     /locus_tag="RxyAA322_RS04400"
                     /old_locus_tag="RxyAA322_08740"
     CDS             complement(15585..16079)
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accB"
                     /inference="COORDINATES: protein motif:HMM:TIGR00531.1"
                     /locus_tag="RxyAA322_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08740"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="WP_143527095.1"
                     /transl_table=11
                     /translation="MPLSDDDVREILRIIDESDLDELRIETNGLRLYVRRGGAPPREEP
                     EAGGDERRLIEAPKREEPPASGQEASDGRAAEGASGSDGALTIEAPMVGTFYRAEAPGA
                     RPYVEVGSRVEPDTVVCLIEVMKMMNSIRAGVSGRIAEVCVENGELVEYGQPLFRVEPD
                     R"
     gene            complement(16080..17174)
                     /locus_tag="RxyAA322_RS04405"
                     /old_locus_tag="RxyAA322_08750"
     CDS             complement(16080..17174)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.4"
                     /locus_tag="RxyAA322_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08750"
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_143527096.1"
                     /sec_met_domain="PPDK_N (E-value: 4.1e-101, bitscore:
                     336.0, seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASTTMPGHTVSLGELRRAAEPHFGGKSANLGELLASGIPVPPGF
                     AISAGAFGLFLEENGLRERVSEVLRELDADDVKGLRSVSGELYQLICSAPLPEALEGEI
                     LRRYREIAGAAGEENPPVAVRSSAIGEDSEQATFAGQQKTYLWVRGAESVCEAVRKCWA
                     SLYSPEALSYRARMVAAGSEPAMGVTVQMMVDAEVAGVMFTCNPLSGDPSTVAVNASWG
                     LGEAVVAGEVTPDEYRLSKVTGEVLHRSIGRKHLEYRPDPASAGVRTVEVEPERQEISC
                     LEEEHLRALVEVARRVERHFGTHQDIEWALARGRGLPDALFVVQSRPVTTVRRRGGEPP
                     RARSAIELVMGTFGVVSDEERGRS"
     gene            complement(17167..18915)
                     /locus_tag="RxyAA322_RS04410"
                     /old_locus_tag="RxyAA322_08760"
     CDS             complement(17167..18915)
                     /GO_function="GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564554.1"
                     /locus_tag="RxyAA322_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08760"
                     /product="PEP-utilizing enzyme"
                     /protein_id="WP_244299855.1"
                     /transl_table=11
                     /translation="MYPPWALFDERRREHDENRLWFWNSMHFPVPMPAFDMVEVDTPYY
                     ALGGWQNRAFAVPGAMGVDYRIVNGYVYISPNPVTDPEKIAERSRFFQQRAGYYYENWD
                     ELYARWRERMEALNREVSEIPVPGLPEYEPEAVVFEGGEPSWATLLASYRRALDCIERM
                     WQYHFEFLLLGYGAYLTFSEFCKQALPDIPDQHISQMVAGIDVVLFRPDAELRRLARLA
                     IDLGVAEAFREGRSPEEIEAELGRSDAGRRWLEELEEVKDPWFNMGTGDGLYHYYGSWH
                     DDPSIPYSSLIGHIAALQAGEDIERPTRELAERRDRLVGEYEALMDEEARQTFRELLGL
                     SRKVFPYVEEHKFYCDYWFQSRFFNKIREFGALLARHGFIEEGEDIFQLSRYEVMQALE
                     ELALTWSTGGEALGPHHWPQIVERRKRILKRLEEWTPPPALGRMPEAVVDPAIAMLWGV
                     TPQQLQEWARAQRDGSGNELAGAAASPGEVEGTARVVRSLEEISEVRAGEILVCTSTSP
                     AWAPIFSKIKATVTDIGGIMSHAAIVSREYGLPAVVGTGTATSRIRTGQRVRVDGTNGR
                     VTVLDG"
     misc_feature    complement(19017..19028)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            complement(19119..19817)
                     /locus_tag="RxyAA322_RS04415"
                     /old_locus_tag="RxyAA322_08770"
     CDS             complement(19119..19817)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0006555 - methionine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564555.1"
                     /locus_tag="RxyAA322_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08770"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_244299856.1"
                     /transl_table=11
                     /translation="MELVRRLREGGYAGRALVPHLSARLIRDERHLEEIVARLKEAEVE
                     EVFVVGGDAKEPAGKFRDALGLLEALKELGSPFERVGIAGYPEGHPFIEEKALMEALIE
                     KSAHASYVVSQVCFDAGRVVKWVRKIRGLGVRLPVVVGVAAPIEAMRLARIATRIGVGE
                     SARFLRKQRGWLLRLLLPGKKAGLSYDASGFLEALVREGGGEGVSGIHLYTFNDLKSSV
                     GWVRQEKGKG"
     misc_feature    19908..19925
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(19909..19925)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.43"
                     /tool="antismash"
     misc_feature    complement(20099..20116)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.77"
                     /tool="antismash"
     misc_feature    20116..20134
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.91"
                     /tool="antismash"
     misc_feature    complement(20117..20131)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.36"
                     /tool="antismash"
     gene            complement(20173..20568)
                     /gene="pcaC"
                     /locus_tag="RxyAA322_RS15420"
                     /old_locus_tag="RxyAA322_08780"
     CDS             complement(20173..20568)
                     /EC_number="4.1.1.44"
                     /GO_function="GO:0047575 - 4-carboxymuconolactone
                     decarboxylase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="pcaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564556.1"
                     /locus_tag="RxyAA322_RS15420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08780"
                     /product="4-carboxymuconolactone decarboxylase"
                     /protein_id="WP_172620677.1"
                     /transl_table=11
                     /translation="MRDPRYEQGLRVRREVLGDEHVDRALASATEFTSDFQDFITRYAW
                     GEIWTRPGLDRKTRSCMTMTALIALGRLDELEMHVRAALRIGLTPEEIKEVILHSAVYC
                     GVPAANSAFAVARRVIPESQERKEPGH"
     gene            complement(20565..21353)
                     /gene="pcaD"
                     /locus_tag="RxyAA322_RS15425"
                     /old_locus_tag="RxyAA322_08790"
     CDS             complement(20565..21353)
                     /EC_number="3.1.1.24"
                     /GO_function="GO:0047570 - 3-oxoadipate enol-lactonase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042952 - beta-ketoadipate pathway
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (15-241). E-value: 1e-22.
                     Score: 72.9. Matches aSDomain:
                     nrpspksdomains_RxyAA322_RS15425_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="pcaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564557.1"
                     /locus_tag="RxyAA322_RS15425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08790"
                     /product="3-oxoadipate enol-lactonase"
                     /protein_id="WP_172620678.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-18, bitscore: 65.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.9e-18, bitscore:
                     63.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVELHRVVEGPEDAPVLVLSSSLGTTHRMWDPQVPALKERFRLV
                     RYDHRGHGGSPVPPGPYSIADLGRDVLSMLDDLGVERFSFCGLSLGGMVGMWLASEAPG
                     RVERLVLCCTSALLGPKELWDERARVARSEGMDALVDGVVERWFTPAFREERPETVERA
                     KRMLRETPPEGYAGCCEAIREMDLRDRLGRIRAATLVISAADDPATPPEHGKRLREAIP
                     GARMVIIENAAHLANIEQPEPFTRALLDHLSPVLEGRGSS"
     aSDomain        complement(20631..21308)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RxyAA322_RS15425_Abhydrolase_1.1
                     "
                     /evalue="1.00E-22"
                     /label="RxyAA322_RS15425_Abhydrolase_1.1"
                     /locus_tag="RxyAA322_RS15425"
                     /protein_end="241"
                     /protein_start="15"
                     /score="72.9"
                     /tool="antismash"
                     /translation="PVLVLSSSLGTTHRMWDPQVPALKERFRLVRYDHRGHGGSPVPPG
                     PYSIADLGRDVLSMLDDLGVERFSFCGLSLGGMVGMWLASEAPGRVERLVLCCTSALLG
                     PKELWDERARVARSEGMDALVDGVVERWFTPAFREERPETVERAKRMLRETPPEGYAGC
                     CEAIREMDLRDRLGRIRAATLVISAADDPATPPEHGKRLREAIPGARMVIIENAAHLAN
                     IEQP"
     gene            complement(21354..22706)
                     /gene="pcaB"
                     /locus_tag="RxyAA322_RS04425"
                     /old_locus_tag="RxyAA322_08800"
     CDS             complement(21354..22706)
                     /EC_number="5.5.1.2"
                     /GO_function="GO:0047472 - 3-carboxy-cis,cis-muconate
                     cycloisomerase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="pcaB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564558.1"
                     /locus_tag="RxyAA322_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08800"
                     /product="3-carboxy-cis,cis-muconate cycloisomerase"
                     /protein_id="WP_143527099.1"
                     /transl_table=11
                     /translation="MSGELFGPIFVPKRFREAVSGRAWLQAMLDAEAALARAGARAGLV
                     GEEEAEAIAACCRAELYDPRVIGERAPAAGNPVPALVKELTARVSGVSEEAARHVHRGA
                     TSQDITDTAAMLISREVLGLILSELDALCAACARLAAEHRGTLMPARTLLQQALPTTFG
                     LKAAGWLVAALEARGRLREAREGGLAAQLGGAAGTLASLGEKGPEVLRVYSRELGLPEP
                     VLPWHTARFRIAELGGALALAAGTLHKIALDVILMAQTEVGEVAEPAGEGRGGSSTLPH
                     KRNPILSVTAAANARRVQDLARTLYGALVQEHERAAGAWHAEWETLSDALSLTGGAAAA
                     VREVVEGLQVHPERMRGNLGITEGLILAENVTTLAADRLGRLEAHELVEAACRRVAEGG
                     GTLREELLAEPRLRGALGEEEIDAALDPAHYLGASGRFVDRALEKYRREVQ"
     gene            complement(22703..23296)
                     /gene="pcaG"
                     /locus_tag="RxyAA322_RS04430"
                     /old_locus_tag="RxyAA322_08810"
     CDS             complement(22703..23296)
                     /EC_number="1.13.11.3"
                     /GO_function="GO:0018578 - protocatechuate 3,4-dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046278 - 3,4-dihydroxybenzoate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="pcaG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564559.1"
                     /locus_tag="RxyAA322_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08810"
                     /product="protocatechuate 3,4-dioxygenase subunit alpha"
                     /protein_id="WP_143527100.1"
                     /transl_table=11
                     /translation="MTEEKVQELRLTPSQTVGPYLSLGLLREDWSELVSPDHPQAIRIE
                     GTLYDGAGDPVTDGLVEIWQAAPSGRYDHPADDREDLPLEEGFHGFGRSGTVDEGRFSF
                     VTLKPGPVPGPEGTTQAPHIMVAVFARGLLKQLITRIYFEDEAEANAEDPVLRSIADER
                     LRETLIARKEGENRYRFDIRLQGEGQTAFFKLSE"
     gene            complement(23293..24027)
                     /gene="pcaH"
                     /locus_tag="RxyAA322_RS04435"
                     /old_locus_tag="RxyAA322_08820"
     CDS             complement(23293..24027)
                     /EC_number="1.13.11.3"
                     /GO_function="GO:0018578 - protocatechuate 3,4-dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046278 - 3,4-dihydroxybenzoate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="pcaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011564560.1"
                     /locus_tag="RxyAA322_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RxyAA322_08820"
                     /product="protocatechuate 3,4-dioxygenase subunit beta"
                     /protein_id="WP_143527101.1"
                     /transl_table=11
                     /translation="MQHKPAENRRKILVPQEDEIEQPPYLYPDYVGTRLRAPKEPLIIL
                     PKTLSDVTGPVYGHHRPGELDNDLTRQHEGEPQGQKIIVHGRVLDGDGRPVRNTLVEIW
                     QANAAGRYRHKVDQHPAPIDPNFSGAGRTMTDDDGYYRFITIKPGAYPWQNHYNAWRPA
                     HIHFSLFGRAFRSRLVTQMYFPGDPLFFQDPIFNSVRDEKARQRMISTFDLDATIPEEA
                     LGFRFDIVLEGRYATPFERPHA"
ORIGIN
        1 cggggagaag aagctccatc acaaaagtca tctaacccgc aggcgctctt cccgcgccgc
       61 tcagccgttt cagggctcct ccatccagcc gcgctctacg gcgtagagcg cggcctgggt
      121 gcgatccctg aagccaagct tcctcaggat gctcgagatg tggttcttca ccgtgccctc
      181 ggtgatgtag agggagcggg cgatctcccg gttcgaggcc cccgaggcca cgagccggag
      241 cacctccatc tcccgctcgg agagcggccc ggggccggcg ggctccttcg agaggcgccc
      301 cagctcggag atgaccttca gcgtgatcgg accgtcgagc acggcctcgc cccggtgcac
      361 cttctctatc gcggcggcga gctcctccga gggcgtgtcc ttgaggatgt agcccctggc
      421 accggcccgg agtccccgga agacgtaatc gtcgtcgtcg aaggtggtga ggatgatcgc
      481 cgcgacctcc gggtgctcgc gccgcaggcg ttcgatcagc tctatgccgt ccatccgggg
      541 catcctcacg tccacgagca cgacctccgg cctggccccg ggaaggcgct ccagcgcctc
      601 caccccgtcc gcggcctccc ccactacctc gaccccttcc tccagatcca ggagcgtcct
      661 cagcccctcg cgcatgagcg cctggtcctc tacgatcatc acccgtaccg gaccgctcac
      721 gcccccaccc ccgccggaag ctccacctcg agagcgaacc cgcccccgca ggcgcccccc
      781 gcgctgatcc tgccgccgac ctcctcgacc cgctcccgca ggccctcgag gccgaacccg
      841 cccgacgttc cccccgaagc tccccggccg tcgtccgtca ccgagagccg caccgtctcc
      901 ccgcagagtt ccagcctcac ctccacccgg tctgcgcccg agtgcttgag ggcgttggtc
      961 agcccctcct gcaggacccg gtagaggacg aactcgacct ccgaagggag cgggtgctcc
     1021 tcccccgtta cctcgaagga gaccacgacc cccgagccgt gaaactcgcg caccaggtcg
     1081 tccaggaacc tcaggcccgc acgccgcccc atcgacgggg gcctgagagc ccgcaccgcc
     1141 cggcgggcct cggagagcgc ctcgctcgca gaggccttcg cccgggccac ggcctctgcc
     1201 gcccgtccgg ggtcgcgggc gaggagcttc cctgcggcct cgagctggac gttcaccacg
     1261 gtcaggtggt gcccgacgga gtcgtggatc tcacgggcta tccggttcct ctcttcggag
     1321 accgcgagct cgcgcgcccg ctcggcgtac ctccgcagct cggcgtgggc gtcctcgagc
     1381 tccgcgagca gctcctgggc gtgtatctgc tgcttcatgg cctcgaccgc gagcgtgcag
     1441 atcccgataa cgaacgcgag cggccagctc caggacgccg cctgctccag cgcccagagc
     1501 acacccttct ggggatacat ccacagaagg tcgccgaaca gcagcagcac gataaacccc
     1561 gcgtaggcca ttccccaccg gaacccgaac acgaaaaccc cgttggcgac cgcggcatag
     1621 aggaaacccg tcgtaagacc gaaccccgtc atgcggatta tgaggaagga gacgagcgcg
     1681 aaggcaggga tcgtcaggag cctgaccccg actgcctcat ccctctccca gggcatgacc
     1741 ctcatcagga aagcggcggc cagaaacgcc gccgtcacgg gcaacactcc gaactcccgc
     1801 tccccggaga ggtagagcac ataggtcgcc ccgacgtagg agaaaccaac ggccctcatc
     1861 agcagggccc cccgacgccc ctcaggacct acccgggcaa accagccacc gggatcgttc
     1921 cgccccgtcc tggtatacgt ccagcccttc accttcgccc gcatcccggc cttcctcagg
     1981 cagcaacgct cgagaagccc ttctgttggg atcatcctac cgccgcccgc gtccccgcgc
     2041 atgtgccgga ggtcatgcag gagtcacgta gggcatgtga gaaacgtcag ccttagagac
     2101 cctgcatcac acccacgcct tcctcgtacc cggtgaaagc gctgaagcgg cgcaggcgcc
     2161 cctccatcgc cggacaaccg cgagggtctt ctcgtcgtag gcgttggtgc cggtgcggta
     2221 gatggcctgg atgaagccct cggttgagcc ccacggcatc tattgctgcc gcactgctgc
     2281 caatagcctc cggtggatcc accggaggcc atcccagatt ccgagcattc ggcctatcca
     2341 ggggaaataa gagagggtga ccgacgggat tcgaacccgc gaccttcgga gccacaatcc
     2401 gatgctctac cgactgagct acggccacca agcgcacgcc gattctatca ggaacggcgc
     2461 gatcttacag catcccgagc cgtctcagga gcggtgggcg gggagctcca ccaggacgtt
     2521 gcgcccggcc ccgaccccgg agagcagcat gcacgccgtg atcccaagga gcaaggccag
     2581 aggcaacgcc cagccaccgg tgaggtcgtg cagcgctcca aacagcggcg ggcccgccgc
     2641 ggcgagcaga taccccaccg tctgggccat cccggagagc gcggccgcgc ccgcggcgtc
     2701 cggggcgcgc agcgcgaaga gggtgagggc gaggctgatg gccgctccct gtccgaggcc
     2761 gagcagaaag accgggacag cgctcaacat ccctccgaag aacatgaggc ccaggatgcc
     2821 ggacccggag agcaccgccg ccccggcggc aagggcgctc tgggagcgca tccgggctgc
     2881 caggatcggc accaagaggg tggcgggaat cccgaccacc tgcatgagcg agaccatcac
     2941 cccggccccg gccgcgtcca acccgccgtc gcggagaatg gcgggaagcc aggtgatcga
     3001 gacgtagaaa acgatggact gcagtcccat gaacagggtc acctgccagg cgagagccga
     3061 ccgccacagg ccctgcaaaa ggcgcacgcc ccctccggaa gatccaccct ccgggcgctc
     3121 gccgagcagc ggaacccata ccacggccgc gagcagcgcc agagcggccc agatcccgag
     3181 agcgccctgc catccgagtc ccgcggcgcg ggccaccgga acgctcagcc cggccccgag
     3241 cgcggccccg acgttcatcg cggttatgta ggcgcccgtg gcgagtccca cacgccgggg
     3301 gaagtaacgc ttgacaaaac cggggagcag aacgttcgcg gcggctatcg cggtgccgag
     3361 gatggccgtg cccgcgaaga gcgccgccac gtgcggcagc gaacgcaggg cgatccccgc
     3421 ggcgagcagg accaggcccc cgaagagcgc gcgggtcagc ccgatccggg ccgcgagccg
     3481 cggggcaaag ggcgagacgg cggcgaaggc gagaaggggg agggtcgtga gcagaccggc
     3541 gaggccgccg gagagcccga gatcttcccg gatgccctcg atgacgggtc ccaccgaggt
     3601 tatcgaggcg cgcaggttga gcccggcgag caccacgcag gagaaccaca aggcaacccg
     3661 gacgaccccc gaccccttca cgtaaatccg ctccggggaa ccgggctact ccatgggaag
     3721 ccccgtgtag ttctcggcga gagaggtgga ggccgcccgc gagccggtga cgtagtccag
     3781 ctcggcgagc tgcagccggt aacggaactc gtcctcgccg tggaagcggt ggagcatcga
     3841 ggtcatccac caggagaagc gctgcgcctt ccacacccgg cgcaggcacc gctccgagta
     3901 ggcgtccaga aggtccgtgc gccccgaagc atagaagccc gttatggcct cgcacagcac
     3961 gcgcacgtcg gcgaccgcca ggttcatgcc cttcgccccg gtgggaggca cgatgtgggc
     4021 ggcgtccccg gccaggaaga gcctgccgta gcgcatcggt tcgcagatga agctgcgcat
     4081 ggccacgatg ttcttctgca ggatcgggcc ttccttcagc cgccatccgt cctccgccat
     4141 ggcgagccgg gcgtgcagct cctcccagac gcgctcgtcg ggccagttgg ccacgtcgtc
     4201 atcgggatcg cactgcaggt acatgcgctg gatctgcggg gagcgggtgc tgatcagggc
     4261 gaacccccgc tcgtggaggc agtagatcaa ctcctccgaa gatcgcggcg cctcgaccag
     4321 gatgccgaac cagccgaagg ggtagtgccg ctcgtactcc ctgcgggccg tctcggggat
     4381 ggacgggcgg cacaccccat ggaacccgtc gcagccggcg acgaagtcgc aggagagttc
     4441 ctcctccctc ccgctccggt ccgcgtaccg gacgaccgga gattcagtat ccgccccctc
     4501 cacggcgagg gcctgcgcct cgaagacgat ctccccgccc gaagcgagcc gcgcggagat
     4561 gaggtccttc accacctcgt gctgaccgta gagcatgatc cctcgcccga cgaggtcctg
     4621 gaagtctatg cggtgccggc gtccgccgaa ctgcaggttc accccacggt ggaaggcgcc
     4681 ctccttcatc atccgctccc ccaccccgat ctcgttcagg agatccaccg ttccctgctc
     4741 cagcaccccg gcccggatct ccgactccag ctcctcgcgg ctccggcgct ccagcaccac
     4801 cgactctacc ccccgcaagt gcagcaggtg cgcgagcaac agccccgcag gcccgccgcc
     4861 cactattccc acctgggtcc gcataaccct cctctacctc gaagcctcct cgaaccatcg
     4921 ggcaagaaac atgctagcac cgcagggagg acctccgctt caccccggga aggccacccg
     4981 cccccgccgg tttcggcggg ggcgggtcgg tgagagtgcc cgtgatgacg atcctggtca
     5041 aacgcctccc taagacctcc ggtaggcggt gcgggcgaac tccaccagcg gagcgggctg
     5101 cacggtggcc cttatctcca cctgccggtg ctcctccacc gtgggcttgg agctgttggg
     5161 ctcctcgccc cacaagagca ccacctcgct gccgggctcg gcgacctcct cgtccaccac
     5221 cgccaaggac agcatcgacc gctcgttgta gctgtagccg gtgtaggttg agaccccaac
     5281 gacccggcca tccttctcta ccctgtcgta gggcagcgtg gcgtagttgg agagcgggag
     5341 gtctatgtac ttggcgggga gcccctcccg ctcgaagagg gaggcgaaga cctcctttac
     5401 gtcctccccc tcccacacca gcgtcacctt cctgcggtgc ggcccctcgg ccatctcctc
     5461 cagcgcctcc cgacccacga agtcgtggtc gaacttcacg aagcgcccgt agccgagctc
     5521 gtagggggtg aagtagtagt cctctatcct ctccgagtag aagctcccgc cgagggaggc
     5581 catggcctca taaccgtttg cggggagcca ctccctgtag ggcttcatct gctccccggt
     5641 gtagatggcg ggacagggcg aggggatcca gccggactcc agcgtgttgg tggcgtaggt
     5701 cctggagccc acctgcttga ggccgtactc ctcaccggcc tcgatgatta tgcccttgat
     5761 ctcgtcccgc tcctcccacg ggccgaagat ctcagcgccc ggctgcccgc tcatgccgtg
     5821 cctgagcgcc cgcaccttgc gcccgccgat gttgatctcg tacatgttga agaacggcac
     5881 ctgcggcaga ggcccgccgt tcagcttctc gagcagctcg cccgcgttgg gtccctggat
     5941 ctggtagcga tagagccgcc ggcgcttctc ggggttcacg gcgtagcgct cgtcccgctc
     6001 caccttcacg tcgtagtccc cgttctcggc gtggtactgc acccagttgt gggctgtcgg
     6061 ccgcccgacg aggctgaccc gatcgtcctc gagcccgaac aggaccgcat cgcctattac
     6121 gtagccgtcg gggttgcagg ccacgaactg cttggcgttg ttcttcttga agccctcgaa
     6181 actgttgatc ccgaggtcgg agagcagccg cttcacgtcc ggcccctcta tatagaggtc
     6241 ggtcatgtgg taggactggt cgaagagcac gcagctctcc ctccaggccc gctgctcgtc
     6301 ccgccagttg gtgaactccg ccggaacccc ggggaaggcg taaggcccta tctgcgagtt
     6361 cctcagcagc tccaccgggc tcctcgcacc cgcgagcaaa tcctccaggc tgcgcctgct
     6421 catgatctcc ctgaacctcc tcccgatgac accctattca tatacacacc cctcggagaa
     6481 ccgctgctca aacgtacatc ggcacacctc ccggcgcaaa tactgttttt attgctcctc
     6541 atatcccccg gatatagccg gggcagctac cggaagccac cgtcgtcccg gaaaacggga
     6601 ggagctccac cgcgcagccg cggcggtgtt cttgagcaac cacacgtcgg ttatgggccc
     6661 caccccgccc ggaaccggcg tcaacgcctc ggccttccgg gcgacgctct ggaagtccag
     6721 atccccaacc agtatggtcc tcccaccccc ctcggggtcg gcgaccgggt ttatgcccac
     6781 gtccacggcg atcaccccct ccctgacgta gctttcgtct atgaggccgg caacccccgc
     6841 cgccacgatg agtacatcgg ccctcacggt ctgctcgcgc agccgccccg cccggtaggt
     6901 gttcacgtcg caggagatga cggtcgcgcc gcgggcgaag cccagcgaga cggcgggttt
     6961 gccgacgttg ttggacctcc ccaccacgac cacggtgctg ctgcggtagt actcctccgg
     7021 gtcgcgcccc gagagcttca ggtagcgatc cagcaagtag aagcacgccg cgggcgtgga
     7081 gggcacgtag cggggcctcc cgagcgcgag cagcccggcg ttgaccgggt gcacggcctc
     7141 tatgtctttc aggggatcca gcatcctgta cactgcgggc tccgagaccc gctccggaag
     7201 gggccgcaag acgagtatcc ccgagacccg cgggtcggcg ttgagcttgc cgaccaccgc
     7261 gagcacgtcg gcctcctcgg cctcctccgg aagccgctcg cacgtatagc ggcacccgag
     7321 ctcgccggcg agctttctca cccgccgctc gtaggcccgc gccgcgtagt cctcccccac
     7381 gaacacggtg gcgagcccgg gcctcacgcc acccgcagca agctcctcca cctccgagat
     7441 tacccgcagc ttgagctcct cggccagagc cctcccgtct atgacgcgcg cccccaaaag
     7501 acctaccctc ccccctccaa cgcctcacgc tcccggaagg cctcctcgac gaaccgctcc
     7561 accctccgcg ccttctcccc ttccggctcg ttggccctca cgagctccgc cgcaacccgc
     7621 accccggcct cggcgagcag caccgccgcc accgcatctc ctttgaggtt ggggttcccc
     7681 tcacgcacca gccgggaggc gatgcgggcc acccgagttc ccaccctcgc catctcaagc
     7741 ggcaccgccg cagcctcctc gagtgcctcc cgtatgcgct cctcacgacc ctctctgccg
     7801 cgcggcaggc ggtaggcggc gagtacccgc ccgaaggctt cggcgtcggc ctgggcgagc
     7861 ggggcaacct cctccctgag ctggtccgcc tcccgcgcca gcgtaccggc ctcctcgagg
     7921 tgttccgggg agaggcgcgc cgccatcccg gcgagcccgg cggccagagc cagcgccacc
     7981 gccgcagcac ccccgccccc cggagcggac tccccggagg ccagagcctc gagaaaccgc
     8041 cccaacggca tccgcaagta gtccggtgcg ccggacgtac cgctcaaaag agccccacga
     8101 cgttgcccgc ctcgtcgagg tctatgccct cagccgcagg atgggccgaa agccccggca
     8161 tggtgcgcat ctgcccgcag atggggtaga tgaaccccgc cccaacagag gccctcacct
     8221 ccctcaccgg tagcttccac cctctgggcg cccccttgag cgccggatcg gaggagatgg
     8281 agaggtgggt cttggctatg catacgggta gcctcccaaa gcccgccttc tcgtactctt
     8341 caagctgcct ggccgcttcc tggtcgtact ccaccccttg ggccccatag acttctgtgg
     8401 ctatggtctc tatcttctgc tttaagggcg cctcaagcgg gtagagaaag cggaaggagc
     8461 tgctttgtcc tcctcttttc tccttttcgt tctcttctat ggtctcctcc agcgcttcag
     8521 cgagctccac ggcccctttg ccccctttga ggaagtggtg gcaaacagcg gctctcgctc
     8581 ctgcctctcg tgccacctct tctatggctc tgtgctctga ggggtggtcg gtggggaagg
     8641 cgtttatggc cacaacggcc ggtaccccgt gcagctttat gttctccagc tgcttcttga
     8701 ggttctccgc ccccgccaac acgtcttcgg ggttctcttt taagagctct tcgggcaggg
     8761 gcgcgccggc ctttatctgg tagcgcccgg agtgggcctt tagcgcccgt accgtgctga
     8821 ccactacggc agcgtcgggc ttcagccccg agatgcggca ctttatgttg aagaagcgct
     8881 cggcccccat gtccgcccca aagcccgcct cggttatgag gtagtcgccg cagtggatgc
     8941 ctatgaggtc ggcaaccaca gaggagttgc cggtggctat gttgccaaag ggacctgcgt
     9001 gcacaagggc aggggtcccc tcaagggtct gcatgaggtt gggctttacg gcctccttga
     9061 ggatcaccgc catcgctccc gcagctttca gatcctccgc gctaatgggc ctgccttctt
     9121 tgtccacacc cacaactatc cgcccaaggc gctctcttaa gtcctcaagc gaggtgcaaa
     9181 gggcgaggat cgccatcacc tcagaggccg ccgttatgtc aaagcccgac tggcgcggaa
     9241 tgccgtccac cctcccccca agccctatga cgatgttcct caaagagcgg tcgtttacgt
     9301 ccatcacccg ccgccagctg atcgagtggg ggtctatacc caaggagttg ccctggtaga
     9361 ggtggttgtc cagcatcgca gagagcatgt tgtgcgcctc ggtgacggcg tgcagatccc
     9421 cggtgaggtg cagattgagc cgctccatcg gtacaacctg gctgtagccc ccaccagcag
     9481 ccccaccctt tatcccaaag gccggcccca tcgaagcctg ccttatggct atggtcgccc
     9541 tcctgccgat gtgcgagaag gcctgcccca aaccaacggt ggtcgtggtc ttgccctccc
     9601 caagaggcgt cggggttatc gccgagacca gcacgtagcg cgcccggggt cttcccccaa
     9661 gctcctccat ggcctcaagc tttatcttcc caactccctc cccatagggc tctatgagct
     9721 cctcgcgctc tatgcccata gagcgtgcaa cctctcctat gggcaacagc ttcgcccccc
     9781 gcgctatctc tatgttggac ggtacgctcc cagtgctcat cccctaaaat cctcctccct
     9841 cgtgccagcc gaccggtgag atcacctctc ctccctaccg gacaccgacg aaaccgatgt
     9901 cccatctatg tcatcaatct tgttaacaat attgtacaat ctactataac acggatgcga
     9961 ggagggtgaa aggccgcgtc cctgccaggc gagagatgcg tcaggcatcg tgcgggtgtc
    10021 tacgggatgc agcgtacgcg gcgaaggcgt cgagggcggc cggatccagg agggagtcgc
    10081 ggcttgcgac ctcctccggg cgggcgccgc gcaggatgcg cttgacgggc acctcgagct
    10141 tcttctggga gagcgtacgg ggtatggagg aaacggcctc gatggtatcg gggacgtggc
    10201 gcggggagag ctcgcggcgg agggtggcgg cgatgcggga acgcaggctc tcgtcgagct
    10261 ctgtgcccgg cgccgggacg acgaagagca agagctcgcc gggtccgcct tcggcgtctt
    10321 cgaggtggac gacgaggctg tcggcgacct cctcgaagga ctcgactacg gcgtagatct
    10381 ccccggtccc caggcgcacc ccgccgcggt tgagcgtcgc gtccgagcgg cctgagatca
    10441 cgcagcttcc gcgctcggtg aagcggatcc agtcgccgtg acaccagacg cccgggaaac
    10501 gctcgaagta cgcggcgcgg tagcgcctgt ctccgggatc gttccagaag ccgagcggca
    10561 tcgagggcat gggagagcgg atcacgagct ccccgaactc gccgacgacc ggtcggccgc
    10621 gctcatcgta ggcggcggcg tctacaccga ggcaggggcc ggagatctca ccccggtaga
    10681 ccggctgcag cgggctcccc tgcacgatgc ccgtgcacac gtccgtgccc ccactgccta
    10741 tgttcagcag cacgtcgggg ccgagctgct cgtagaccca gtcgaagccc tccggcggca
    10801 gcgggctccc cgccgcccct atctgccgca cgctcgagag gtcgaactcc cgcccgacct
    10861 cgaggccggc cttgcggcag gccatgagga aggccggggc gacgccgagc atcgtcgcgc
    10921 cggtctgctc ggccagccgc cactggaagg cgagatccgg gtagagcggg ttgccgtcca
    10981 tggtgactat cgcagaccgc aggagcagcg ccgagacgag ggcgttccac atcatccagg
    11041 cggtcgtcgt gaaccacatc agccggctgc ccggacggag atcccaggtc agccccaggt
    11101 tcttgaggtg ttcgaggagg atgccgccgt gcccgtgcac tatggccttg ggcttgccgg
    11161 tggtgcccga ggagaagagc acgtagagcg gatgatcgaa ggggaccggc tcgcagcgga
    11221 gcggctcctc ctccgagagc agctcctccc aaccgaccga atccggcaga acgtcctccg
    11281 cccctccgac gtacgggacg tgcacgacgt gctccagcgt gggcagcgcc cgccggatgt
    11341 cccgcacctc cgcccggcgg tcgatgtgct tctccccgta gcggtagccc gtcaccgcga
    11401 gcagcacctt ggggtcgagc tgcccgaagc gatcgatcac gctgcgcgga ccgaactccg
    11461 gcgcacaggt cgcccagatg gcccccaggc tcgcggtggc gaggaaggcc acgaccgtct
    11521 ccggaacgtt cgggaggtag gcggcgacgc ggtcgccggg gccgaccccc aggcgccgga
    11581 gcccggcgcg ggcccgcgcc acctgctcgc gcagctcgcc gaaggtcagc tcgaagggag
    11641 cccgcgtctg ggagtgggcg aagatggcga cctcttcgtc gtcgtctgag ggggtgagga
    11701 tcctctccgc gtagttcagg cgcgcgcccg ggaaccagcg ggcgccgggc atctcgcgcg
    11761 cggcgagcac ccgttcggga ggggtgtggg cgcgcacgcc gtagaagtcc cagacagagc
    11821 gccagaacgc ctcgagatcc cccaccgacc agcgccagag ctcgtcgtaa ccctcgaact
    11881 tgaggccccg ctcctcgcgc agccagcgca cgtaacgccc gatctcggtg gtctccagga
    11941 cgtccgaggg cggcgtccag agcacctcgc ccgtcagagc cacttcagga tctcccccac
    12001 tccctcaacc accgcatccg ggcgccggcg ttccggcacc cgctgcaggt ccaccgaccc
    12061 gctggtcccg ctgcgcacca ggatggtgaa cgagcccccc aggcgaccca gcccgatatc
    12121 catgtccagg tcatctccga tgaccgccat ctcccgggat tccaccccga gccgctcgca
    12181 ggccgcgcgc accgccatcc gcgagggctt gccgaccacg atggggcgct tccccgtagc
    12241 cttcaccagc gcagcggtca ccatcgcgcc gcggctgaag atcataccgt tcgcccccca
    12301 gtagccggga ccgtagctgg ccgtgagaag gggcgcgccc cgggtgatgg cccgcgccgc
    12361 gcgttccagg gagtcgaagt ccacctcgtt tacgtgggtg acgaagacca cttcggcgtc
    12421 ctccccgtcc gtgagcggca ccccggcctc cgccatgcgc tcgcgggtcg tttcggagcc
    12481 gaagaccatg gtccgccgtc cgccgtggcg gcgcgccaga tacccgagcg cgctgcagac
    12541 gggggtcagg acctcgtcgt cgcgcacggg gagcccgccc tcgcgcagcc cccgcgcgaa
    12601 ctcctcggga cgcaggtgcg tgccgttggt gaacagcacg agcggccggc cggaggtccg
    12661 gatcttctca agcacctccg gcgcgccggg gagcggccgc gggtgaaagc cggcgtcgcg
    12721 gtgcacgagc gagccgtcca cgtcgaagac gaacccgcgt atcctctcaa gcttctttgc
    12781 gccagacaat ggtatccccc gtacgttcgt cttcgagcct cagataagag atggagtcgc
    12841 gcctggagag ctcgtgcagg agccgcacga ccggtgcgcg tccggggcgc accagcggcg
    12901 cgcgcggcct gccgcgctcg gcgaccatgg cgtccacctg ctccgcaggc atcgtgaggc
    12961 gcaacagcag ctcctcgtcg gagatccggc gaccgaagcg ctcgcgggcc ccgtccagag
    13021 agatcggttc gagatccttc agctcggagg cgcgcggcgt cgagagcacg cggtcggcga
    13081 cctcggggtc gacgggcgcc ggggtctcgt agtagtgccc gaggaagtag cgcaccatct
    13141 cgtccgagac cctcgaccag cgctcgccgg agatgacgtt catcacggcc tgggtagcga
    13201 cgaactgcga gaccggggtg accatgatgg ggtagcccat ctccgcgcgc acccggggga
    13261 cctcctccag gacggcgtcg aagagctccg gccggcccag ctcctgcagc tgccgacggg
    13321 tggtggagat catgcccccc ggcatctggt gccggaagta ggcgccgtcg aactcccgcg
    13381 ggctgccggg cggcaacccg cgctcgcggg ccagctcgtc gaagtactcg gagacggcct
    13441 cgagcgcctc cgtatccagg tcgtacgaga ggccctcggc ctccacgttg cgcagcgtgg
    13501 atttggcggg aggattcgag cttccgctcc ccagcggctc caccgcggtg tgcagcgtcc
    13561 gcaccccgga gcgcagcccc tcgacgtagg cgaggggacc gagcccgatc gtgcagtggc
    13621 tgtggagctc gaccgggcgg ggggcgaagc gctcgatgaa gcccgggatc agggtgcgca
    13681 ccgcctccgg catcaggagc cctcccggat ccttcaggta gagccggtcg atgtcctcgg
    13741 agcgggagac cgcttcagcc cgctccaggt agtagtcgtg ggtgtggacc gggcttatgg
    13801 agtaggtcag cccgacgacg acctcctcga aaccctcctc tcgtgcgacg cgggccatcc
    13861 ggaggagcgc ctcgggctgg ttcgagggat cgacgatctg gatcctgcgc atcccgttgc
    13921 gcacccagca gcggaaggcc aggcgcatga cgtcctcgcc ggcggggacc caacggatga
    13981 agcgcatgcc ggtggtgata agccccagcg gcgtgttcgg catggctgcg ctcaccagcc
    14041 ggatccgctc ccagggatcc tcccggtgga agcggacgga gaccgccatg tgcgtgctgg
    14101 aggtgaagtc cagagcgtgg aaaccgacgc ggtccatcgt cggggctatg gcgaggacgt
    14161 cctgggtggt gagcccggtc gcggaccaca ggctctggtt gccgtcgcgt atggtcgtgt
    14221 cgacgatctc aacggtatcg ctcatgccgc aagcaccgcc tcctcgagcc aggtcgtgtc
    14281 caccgccgca ccggtgaagt ccgggtgggc gagaacgtgc atcagcagct cgcggttggt
    14341 gggaacgccc tccaccacga gcccctcgag cgcctcgcgc atcctctcga tcgccccttc
    14401 gcggtccccg gcgcaggaga cgagcttcgc caacagcgag tcgtagtagg ggggcacgag
    14461 cgtcccctcc tcacagtggg tgtcgacccg caaaccctcg atctcgggga ccgaaaaacg
    14521 cgagatcctg cccggggtgg ggcggaagcc gtgggcggga tcctccgccg tcaggcggca
    14581 ctctatcgcg tgcccgcgaa actccacctc ctcctgcgag aggccaagcc tctcatccgc
    14641 cgcgatcctc agctggtccg ccacgaggtc acgcccggtc accgcctcgg tcaccgggtg
    14701 ctcgacctga atgcggcagt tcatctccat gaagaagaat tccccgctct cggcgtcgac
    14761 cacgaactcc acggtgccga ggttgcggta gccgatctcg cgggcgaagg cgacggccgc
    14821 cccgtggagc gccgcgcgcg tcccggcgtc cagcccgggg gccggagcct cctcgacgat
    14881 cttctggtag cgtcgctgca ccgagcagtc gcgctccccg aagtggagca cgccgccgtg
    14941 ctcgtccgcc gccacctgca cctcgacgtg gcgggcgctc cggatgaagc gctccacgta
    15001 caggcgttcg tcaccgaagg ccgcccccgc ctcggcgagc gcgaccccga acagccgctc
    15061 cagctcctcc cggtcccggg caagtttgat cccccgcccg ccaccgcccg ccgcggcctt
    15121 gagcagtacc gggtagcccg cctcctcggc gaagcgcaaa gcgtcggcga gcgcgctcac
    15181 ctcgccgccc gggacgaccg gcagcccggc ctcggccgcg acctcgcgcg agcggagctt
    15241 gtccccggcc agctctatca cctccgcggg gggcccgacg aagcgcagcc cgttctcgca
    15301 cgcggcggcg gccagcgcgg ggttctcgga gaggaatccg tagccggggt ggatggcgtc
    15361 gcagccggtg ccgatcgccg cctgcaccac cgcgcccacg ttcaggtagc tttgcgccgg
    15421 tgaccccggc ccgatgcaca ccgcccggtc ggccatgcgg gccgccaggc tgccgcgatc
    15481 tgcctcggag aaccccacga cggtctccag ccccagctcg cggcaggaac ggacgacccg
    15541 caccgcgatc tcaccccggt tcgccacgaa gacgcgtctc atcttcaccg gtcgggctcc
    15601 acccggaaga gcggctggcc gtactccacg agctctccgt tctccacgca cacctcggct
    15661 atcctcccgg agaccccggc acggatggag ttcatcatct tcatgacctc gatcaggcac
    15721 accaccgtgt ccggctcgac ccggctcccg acctcgacgt agggcctggc cccgggcgcc
    15781 tcggcacggt agaacgtgcc gaccatcggc gcctcgatgg tgagggcccc atcggagccg
    15841 gaggccccct cggcggccct cccgtcagaa gcctcctgtc cggaggccgg aggttcctcc
    15901 cgtttcggcg cctcgatgag acgccgctcg tcgccacccg cctcaggctc ctcgcgcggc
    15961 ggtgcgccac cgcgccgcac gtacagcctc agcccgttcg tctcgatcct caactcgtcc
    16021 aggtcggact cgtcgatgat ccgcaggatc tcacgcacat cgtcgtccga gagcggcatt
    16081 caggacctgc ctctttcttc gtcggagaca acaccaaacg ttcccatgac cagctcgatc
    16141 gccgaccggg cccgcggagg ttccccaccc ctgcggcgca cggtggtgac gggccgggac
    16201 tggaccacga acagagcgtc cgggagcccc ctcccccggg cgagcgccca ctcgatgtcc
    16261 tggtgggtgc cgaagtgccg ctccacgcga cgggcgacct cgaccagcgc ccgcaggtgc
    16321 tcctcctcca ggcaggatat ctcctgccgc tccggctcca cctccaccgt ccgcacaccg
    16381 gccgaggcgg ggtcgggccg gtactccagg tgcttgcggc cgatggaccg gtgcagcacc
    16441 tcaccggtca ccttgctcag ccggtactcg tccggggtca cctcccccgc cacgaccgct
    16501 tcgcccagcc cccagctcgc gttcaccgcg accgtgctgg ggtcgccgct gagcgggttg
    16561 caggtgaaca tcacgccggc gacctcggcg tcgaccatca tctgtacggt gacccccatg
    16621 gccggttcgc tccccgccgc gaccatcctc gcccggtagc tcagcgcctc ggggctgtag
    16681 aggctggccc agcactttcg gaccgcctcg cacacgctct ccgcaccgcg cacccagagg
    16741 taggtcttct gctggccggc gaaggtggcc tgctcgctgt cctcgccgat cgcgctggag
    16801 cggactgcca cggggggatt ctcctcgccg gcagccccgg cgatctcgcg gtaccggcgg
    16861 aggatctcac cctccaacgc ttccggcagg ggagcggagc agatcagctg gtagagctcg
    16921 ccggagacgc tccgcaaccc cttcacgtcg tccgcgtcca gctcgcgcag tacttccgaa
    16981 acgcgctccc ggaggccgtt ctcctccagg aagagcccga acgcgccggc cgagatggcg
    17041 aaccctggcg gcaccggaat gccgctcgcc aggagctccc cgaggttcgc gctctttccg
    17101 ccgaagtgcg gctccgcggc gcgcctgagc tcgcccaacg agacggtatg accgggcatc
    17161 gtcgtgctag ccatcgagga ccgtcaccct cccgttcgtg ccgtccaccc gcacccgctg
    17221 gccggtcctg atgcgggacg tcgccgtgcc ggtgccgacc acggcgggca gcccgtactc
    17281 ccgcgagacg atcgcggcgt gggacatgat ccccccgatg tccgtgacgg tggctttgat
    17341 cttgctgaag atcggagccc acgccggcga ggtggaggtg cacaccagga tctccccggc
    17401 ccgcacctcg gagatctcct cgagagagcg caccacccgc gccgtcccct ccacctcgcc
    17461 cggcgaggcg gcggcgccgg cgagctcgtt gccgctcccg tcgcgctgcg cccgcgccca
    17521 ctcctgcagc tgctgcgggg tgacccccca gagcatggcg atcgccggat ccacgaccgc
    17581 ctccggcatc ctccccagag cgggcggcgg cgtccactct tcgagccgct tcaggatccg
    17641 cttgcgccgc tccacgatct gcggccagtg gtgcggcccg agcgcctcgc cgccggtcga
    17701 ccaggtgagc gcgagctcct ccaacgcctg catcacctcg tagcgggaga gctggaagat
    17761 gtcctcgccc tcctcgatga agccgtgccg ggcgagcagc gcaccgaact cccggatctt
    17821 gttgaagaac cgcgactgga accagtagtc gcagtagaac ttgtgctcct ccacgtacgg
    17881 gaagaccttg cgcgagagcc cgagcaactc ccggaaggtc tgccgcgcct cctcgtccat
    17941 aagcgcctcg tactcgccga cgagccggtc ccgccgctcg gccagctcac gcgtgggccg
    18001 ctcgatgtcc tcgccggcct gcagcgccgc aatgtgcccg atgagcgagc tgtaggggat
    18061 gctggggtcg tcgtgccagc tgccgtagta gtggtagagc ccgtcgccgg tccccatgtt
    18121 gaaccacggg tccttgacct cctcgagctc ctcgagccag cgccgcccgg cgtcgctgcg
    18181 cccgagctcg gcctctatct cctccggcga acgcccctcc cggaaggcct ccgccacccc
    18241 gaggtctatc gccagccgcg ccagccgccg cagctcggcg tccggccgga agaggacgac
    18301 gtcgatgccg gcgaccatct gcgagatgtg ctggtcgggg atgtcgggca gggcctgctt
    18361 gcagaactcc gagaaggtca ggtacgcccc gtagccgagc agcagaaact cgaagtggta
    18421 ctgccacatc cgctcgatgc agtccagcgc ccgccggtag ctggcgagca gcgtggccca
    18481 gctcggctcc ccgccctcga agacgacggc ctccggctcg tactccggaa gaccggggac
    18541 tggtatctcg gagacctcgc ggttgagcgc ctccatccgc tcccgccagc gggcatagag
    18601 ctcgtcccag ttctcgtagt agtagccggc gcgctgctgg aagaagcgcg accgctcggc
    18661 tatcttctcc ggatcggtca ccgggttggg cgagatgtag acgtagccgt tgactatccg
    18721 gtagtcgacc cccatcgccc ccggtaccgc gaacgcccgg ttctgccaac cgccaagcgc
    18781 atagtacggc gtgtcgacct cgaccatgtc gaacgcgggc atcggcaccg ggaagtgcat
    18841 cgagttccag aaccacagcc ggttctcgtc gtgctccctg cgccgctcgt cgaagagcgc
    18901 ccaaggcggg tacatctcct cccacccctc acacccctcc ggtgtctcga tcgagaacgg
    18961 gctaggaaac gccctgagtt gctctgcttc ggcggtcatc acgctcctcc tttcccatta
    19021 actttttcat tctcgcggcc gcgccggtgc ggccgcaaat accggttcca tatcctcgct
    19081 atacggcccg gatatacctc ctcacccccg gaaggaggtc acccctttcc tttctcctgc
    19141 cgcacccacc ccacggagct cttgaggtcg ttgaaggtgt agaggtgtat cccgctcacc
    19201 ccctctccac ctccctccct cacaagagcc tcaagaaacc cgctcgcatc gtaggagagc
    19261 cccgccttct tccccggcaa cagcagcctc agcagccacc cccgctgttt cctcaaaaac
    19321 ctcgccgact cccctacccc tatcctcgtc gctatcctcg ccagcctcat cgcctctatg
    19381 ggcgccgcca ccccaaccac aacgggcagc ctcaccccca aaccccttat cttccgcacc
    19441 cacttaacaa ccctgcccgc atcgaagcag acctggctga ccacgtagct cgcatgagcg
    19501 ctcttctcga tgagagcctc catcaaagcc ttctcctcta tgaacggatg cccctccgga
    19561 tagcccgcta tccccacccg ttcaaagggg ctcccaagct ccttcagtgc ctcaagcagc
    19621 ccaagcgcat cccgaaactt ccccgcaggc tccttcgcat cccccccaac cacaaagact
    19681 tcctcaactt ccgcctcctt gaggcgcgcc acgatctcct ccaggtgcct ctcgtcccgg
    19741 atcaaccgcg cagagaggtg cggaacgagc gccctgcccg catatccccc ctctctgagc
    19801 ctgcgcacga gctccaccgt gggccccatg cccctggcag gggaggcggt tatggtcagc
    19861 gtggggcttc tctccccttc gtagacccac tcccaaaccc cctcttctat cccctcaagc
    19921 ggtatgatct cgtagcgcag ccgccgcaga agagcggaga tccccttccc actgcccttc
    19981 aacccatcac ccatctaaaa ccagccccct cctggaaacc tccggactcg ccccctcgcc
    20041 ggcggagcca ctccccaccc cgcagccaaa ggaaccgtac cctcttccag cagaaagttt
    20101 aacttatact caacaaaatt gtcaacaata ttgacgacgc aatcgccctc ttctccggtc
    20161 cacgggcggg gttcagtggc cgggttcttt tcgctcctgg ctttcgggga tgacgcgccg
    20221 ggcgacggcg aaggcggagt tggcggcggg gacgccgcag tagacggcgc tgtggaggat
    20281 gacctccttt atctcttcgg gggtgagccc gatcctgagg gcggcccgga cgtgcatctc
    20341 cagctcgtcc agcctgccca gggcgatgag ggcggtcatg gtcatacagc tgcgagtctt
    20401 gcggtcgagg ccggggcggg tccagatctc accccaggcg taccgggtga tgaagtcctg
    20461 gaagtccgag gtgaactccg tcgccgaggc gagcgcccgg tccacgtgct cgtcgccgag
    20521 cacctccctg cggacccgga gtccctgctc gtagcgggga tctctcacga cgagcccctc
    20581 ccctccagca ccggcgatag gtggtcgagc agggcccggg taaagggctc gggctgctcg
    20641 atgttggcca ggtgggccgc gttctctatg atgaccatgc gagcccccgg tatagcctcg
    20701 cggaggcgct tcccgtgctc cgggggcgtc gccgggtcgt cggccgccga gatcaccagc
    20761 gtggcggccc gtatcctgcc cagccggtct ctgaggtcca tctcccttat ggcctcgcag
    20821 cagcccgcgt agccctcggg gggcgtctca cgcagcatgc gcttcgcccg ctccaccgtc
    20881 tccggccgtt cctctcggaa ggccggggtg aaccagcgct cgaccacccc gtccaccagc
    20941 gcgtccatcc cctcgctccg ggccacccgc gcccgctcgt cccacaactc cttcgggcct
    21001 agcagcgccg aggtgcagca gagcacgagc cgctcgacgc gcccgggggc ctcgctcgcg
    21061 agccacatcc ccaccatccc gccgagcgag aggccgcaga aggagaagcg ctccacgccc
    21121 agatcgtcga gcatggacag cacgtcccta ccgaggtccg cgatggagta cggccccgga
    21181 gggacgggcg agccgccgtg cccccggtgg tcgtagcgta cgagcctgaa gcgctccttg
    21241 agcgcgggaa cctgcgggtc ccacatcctg tgggtggttc ccagcgaact ggagagcacc
    21301 agaaccgggg cgtcctcggg cccctcgacc acgcgatgaa gctctaccgt cacttactgc
    21361 acctccctcc ggtacttctc cagcgcccgg tccacgaacc ttcccgaggc ccctaggtag
    21421 tgggccgggt ccagagcggc gtctatctcc tcctctccca gcgccccgcg cagccggggc
    21481 tcggcgagca gctcctcgcg caacgtcccg cccccctccg cgaccctccg gcaggcggct
    21541 tcgaccagct cgtgagcctc gaggcgtccc agacggtcgg cggccagggt ggtcacgttc
    21601 tcggcgagga tgaggccctc cgtgatcccg aggttcccgc gcatcctctc cgggtggacc
    21661 tggagtccct cgacgacctc gcgcacggcg gcggccgcgc cgccggtgag ggacagggcg
    21721 tcggagagcg tctcccactc ggcatgccag gccccggcgg cccgctcgtg ctcctggacc
    21781 agagcgccgt agagggtgcg ggcgagatcc tgcaccctcc gggcattcgc ggcggcggtg
    21841 acggagagga tcgggttacg cttgtgcggg agcgtggagg agccgccgcg cccctctcct
    21901 gcgggctcgg cgacctcccc cacctccgtc tgggccatca ggatcacgtc cagcgcgatc
    21961 ttgtgcaggg tgccggcagc aagcgcgagc gccccgccga gctccgcgat cctgaaccgg
    22021 gccgtgtgcc acggcagcac gggctccggc agcccgagct cccgggagta cacccgcagc
    22081 acctccggcc ccttctcgcc cagggaggca agcgtcccgg ccgccccgcc gagctgggcc
    22141 gcaagccccc cctcccgcgc ctcccggagc ctcccgcggg cctccagagc ggccacgagc
    22201 cacccggcgg ccttgaggcc gaaggtcgtg ggcagggcct gctgcaggag ggtccgggcg
    22261 ggcatgaggg tgccgcggtg ctccgcggcc agccgggcgc acgcggcgca gagggcatcg
    22321 agctcggaga ggatcaggcc gagaacctcc cgcgagatca gcatggcggc ggtgtccgtg
    22381 atgtcctggc tcgtcgcgcc ccggtggacg tggcgggctg cctcctccga gaccccggag
    22441 accctcgcgg tgagctcctt caccagggcc ggcacgggat tcccggcggc gggggccctc
    22501 tccccgatca cccgcgggtc gtagagctcc gcccggcagc aggcggctat cgcctcggcc
    22561 tcctcctcgc cgacgagccc ggctctcgcc ccggcccggg cgagggcggc ctcggcatcg
    22621 agcatcgcct gcaaccacgc ccggccggag acggcctcgc ggaagcgctt ggggacgaag
    22681 atgggcccga agagctcccc gctcattcgg agagcttgaa gaaggccgtc tgcccctcgc
    22741 cctgcaggcg gatgtcgaag cggtagcggt tctcgccctc tttgcgggcg atgagggtct
    22801 ctcgcaacct ctcgtccgct atcgagcgga gcacgggatc ttcggcattc gcctcggcct
    22861 cgtcctcgaa gtagatgcgg gttatgagct gcttcaggag cccccgggcg aagaccgcga
    22921 ccatgatgtg cggcgcctgg gtcgtccctt cgggaccagg cacgggtccg ggcttgaggg
    22981 tgacgaagga gaagcgcccc tcatccacgg taccactcct gccgaagccg tggaagcctt
    23041 cctccagagg aagatcctcc cggtcgtctg cggggtggtc gtagcggccg gagggggcag
    23101 cctgccagat ctcgacgagc ccgtccgtca cggggtcgcc cgcgccgtcg tagagggtgc
    23161 cctcgatcct tatggcctgc ggatgatccg gggagacgag ctccgaccag tcctcgcgca
    23221 gaagccccag gctcaggtag ggaccgacgg tctgcgaggg ggtgagacgc agctcttgca
    23281 ccttctcctc cgtcatgcgt gcggcctctc gaacggggtg gcgtagcggc cctcgagcac
    23341 gatgtcgaag cggaagccga gggcctcctc cgggatggtc gcgtcgaggt cgaaggtcga
    23401 gatcatgcgc tgcctcgcct tctcgtcgcg cacggagttg aagatcgggt cctggaaaaa
    23461 cagcgggtcg ccggggaagt acatctgggt cacgagccgg ctcctgaacg cccgcccgaa
    23521 cagcgagaag tggatgtgcg ccgggcgcca ggcgttgtag tggttctgcc aggggtaggc
    23581 cccgggcttt atggtgatga agcggtagta gccgtcatcg tcggtcatgg tcctcccagc
    23641 cccgctgaag ttcgggtcta tcggggccgg gtgctggtcg accttgtgcc ggtagcgccc
    23701 ggcggcgttg gcctgccaga tctcgacgag ggtgttcctg accgggcgcc cgtcgccgtc
    23761 gaggacccgg ccgtgcacga tgatcttctg cccctgcggc tcgccctcgt gctggcgggt
    23821 gaggtcgttg tcgagctcgc ccggcctgtg gtgcccgtag accggaccgg tgacgtccga
    23881 gagggtcttg ggcaggatga tcaggggctc cttcggcgcc cggagccgcg tcccgacgta
    23941 gtcggggtag aggtatggcg gctgctcgat ctcgtcctcc tgcgggacga ggatcttcct
    24001 ccggttctcc gctggtttgt gctgcacctt ccttccgacc tcctctctat tccaccttct
    24061 cgaggaccat ggcgataccc tggcccaccc cgatgcacat cgtcgcgagc cccagcgtcg
    24121 cgtcctccct gcgccgcatc tcgtgcacca gcgtggtgag gatacgcgcc ccggagcatc
    24181 ccaaagggtg tccgagcgcg atcgcgccgc cgttggggtt gagcctctcg tcctcggggt
    24241 ccatc
//
