LOCUS       NZ_CP041604            10216 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. S1A1-7 chromosome.
ACCESSION   NZ_CP041604
VERSION     NZ_CP041604.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S1A1-7
  ORGANISM  Streptomyces sp. S1A1-7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 58.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007113565.2-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 04:07:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,902
            CDSs (total)                      :: 10,801
            Genes (coding)                    :: 10,337
            CDSs (with protein)               :: 10,337
            Genes (RNA)                       :: 101
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 80
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 464
            CDSs (without protein)            :: 464
            Pseudo Genes (ambiguous residues) :: 0 of 464
            Pseudo Genes (frameshifted)       :: 185 of 464
            Pseudo Genes (incomplete)         :: 374 of 464
            Pseudo Genes (internal stop)      :: 46 of 464
            Pseudo Genes (multiple problems)  :: 127 of 464
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:07:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10654341
            Orig. end                         :: 10664557
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041604.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041604.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="39"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(562..576)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            complement(1881..4103)
                     /locus_tag="FNV64_RS48925"
                     /old_locus_tag="FNV64_49555"
     CDS             complement(1881..4103)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="FNV64_RS48925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_49555"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_054236566.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.8e-38, bitscore:
                     130.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPDTRSRRRTAPPKRTVPKAKGKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHLPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDTAALAEVKA
                     PAILFWEFNHYVVYDGMGRRFGRRGVHINDPGKGRRFVPMEDFDTSFTGVVLVMEPGPD
                     FHKGGRKPGVLGAMPARLRGTSGTMPAAVLASLLLVAVGAAVPALSRTYIDTYLIGGRT
                     SLLGVLFASMGACVALTVVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTAVGIGVALLNVI
                     AMRVVIRLRATRTAKLRADNARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSALILWIGGLRAVEGHISVGLLVAFQALVTRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFQTDPLYARSGSGESTRRLQGHVELENITFGYSP
                     LDKPLLTGFSLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWEGTIRIDGQRLEDIPR
                     GALAASVSFVDQDVFLFEGTVRDNVALWDPSIPDEAVVAALEDAALYEVVTRRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQTVIDNLRKRGCACV
                     VIAHRLSTVRDSDEIVVLQHGTIVERGRHEALVAAGGPYAELVKER"
     gene            complement(4100..4909)
                     /locus_tag="FNV64_RS48930"
                     /old_locus_tag="FNV64_49560"
     CDS             complement(4100..4909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="FNV64_RS48930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_49560"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_054236565.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLALSVTVVVMAAASVW
                     AVTGTVASTVSAPAVLTHGEGSYILQSPVAGQVTEVVAQEGERLAANAPVLKVRTTQGG
                     TTVVRTVAAGRVTALAATIGAIISTGANVAAVEKVAHADDPLYATVYVPAESAATIPAN
                     AAVDLTVQSVPTQQYGVLRGHVKAVGRSVQTPQQISSFLGDSQLGEQFSKKGRPVAVLV
                     RLDRSAATKSGLKWSSADGPPFALTSMTLATGSIRLADQRPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="FNV64_RS48935"
                     /old_locus_tag="FNV64_49565"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="FNV64_RS48935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_49565"
                     /product="hypothetical protein"
                     /protein_id="WP_054236564.1"
                     /sec_met_domain="strepbact (E-value: 4.9e-37, bitscore:
                     125.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVATAEISDADLDNVSGGLSLNAVGTVTGLVDGVAPVSGL
                     VNTVVGTVEGVTGLNTAPVTGLVAGL"
     misc_feature    5232..5245
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    complement(5768..5781)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.44"
                     /tool="antismash"
     misc_feature    complement(5769..5782)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.79"
                     /tool="antismash"
     misc_feature    5770..5783
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.15"
                     /tool="antismash"
     misc_feature    5771..5784
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.86"
                     /tool="antismash"
     gene            5886..7295
                     /locus_tag="FNV64_RS48940"
                     /old_locus_tag="FNV64_49570"
     CDS             5886..7295
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988892.1"
                     /locus_tag="FNV64_RS48940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_49570"
                     /product="S1 family peptidase"
                     /protein_id="WP_179858408.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAIAVGGVAALGAAALLLPHANASQTDAKGAAPKT
                     LKSADASNLASLLASQLGDAFGGAYWDASKQQVIVNVVGNNSNVVNTVEKAGAVPRSVN
                     NSLSALKTAAKTLKSDATIPGTAWSIDPKTNQVQVTADSTVTGAKWAKLTSTVDSLGSG
                     VATVKKSAGTFKTFVSGGDAIFAQANGGGVRCSLGFNVTASDGAPAFLTAGHCGVAAKQ
                     WSDSQNGQPIATVDQATFPGAGDFSLVKYDDPATQTVSEVNEGNGKTVQITQAADATVG
                     QQVLRMGSTTGLHDGSVTGLDATVNFQSETVPGGVDTVTGLIQTNVCAEAGDSGGSLFT
                     ADGSAVGLTSGGSGDCTAGGETFFQPVTAALQATGATLGAGGAAGAGGASAAATDPAAT
                     DPAATDPAATDPAATDPAATDPAATDPAATDPAATDPAATDPAAGGQSGTGSGQSSTGM
                     NAGSGLVTSTP"
     gene            complement(7445..9604)
                     /locus_tag="FNV64_RS48945"
                     /old_locus_tag="FNV64_49575"
     CDS             complement(7445..9604)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="FNV64_RS48945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_49575"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_097287906.1"
                     /transl_table=11
                     /translation="MVGVSDWQGSVQAPAGRRTPVGRPLLSLTLASMMEEVHAHSGAVY
                     LLTPGEAVLEMAVMAGMPRSFAAPWERVGLNAPIPVAVAVRERRLVWVGGEEEMARRFP
                     RIAVVLPYPFALAALPVATAGTVYGAVFVTWPGSHPVDLSDRERDHLTASCARLALRLE
                     RAAAERRPVHPEPDLLAPSAAPATGVLGTLEAARMVARLPYGLCALDLNGRVSFANAAT
                     ADMLGVPVSELLGTQLWASVPWLNDPVYEDRYRAALISQHVTSFVALRPPGNWLSFRLY
                     PNTTGLSVRISRARAVAEMGRVESRHGEDDTTPRLVTISQVLSLAGALTQAAGVEDVVQ
                     LVADEIAPAVGSKALVVLGSRSGRLHVLGHRGYADAHIVERWHGVPLSAQTPGTQALKT
                     GVPAFFDSRQQLERLYPDRSATPDGMAAWAYLPLIASGRPVGTCVLGYAEPHTFPAEER
                     AVLTSLCGLIAQALERALLYDAKLQLAHGLQAALLPHSLPTLPSIEAAARYLPATQGME
                     IGGDFYDLVPSHGLAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQPPEEVMRSTNR
                     LLIDLGAELFASCLYLRLDPAREVAVMSRAGHPPPLLLRPDGRVRVLDLAGGPLLGIDA
                     AATYPTTEVPLVPGSVLALYTDGLIESPGVDIEDALADLGRKLAEGGDLSLNALADRLV
                     EQTGAATQERLDDVALLLLRVRPHD"
     misc_feature    complement(9893..9908)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.66"
                     /tool="antismash"
     misc_feature    9899..9913
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.65"
                     /tool="antismash"
ORIGIN
        1 acagcggcag gtacaccgcg cccatcaccg tcgtgaggtt cttgatgcgg ccgaccttct
       61 gctggagctc acggctgcgc gcgaactcgc ccgcccaggc ggcgtacgcg tagttctcgg
      121 ccgccgcgac ccgcagcttg ggcagaccgc gcagggtctg gaacgcctgg ttgttcagct
      181 tgttgctgag cacgaccagg cggcgctgcc agcgcacctg ccacagtccg agcccgagga
      241 acgcggccgc gatgacgacg agcatgccga tcgcggcgag cgccaggggc acgctgtacc
      301 aaaggagcag ccccaggttc atcgcgccga ccgtgcccgc ctgcgcgagc gtcggtccga
      361 cgcccgcgag gaggcggcgg atcgcgctga tgcccatggc ggcgctggcc agctcaccgg
      421 tcgagcggga cgtgaagaac ttcgtgggca gccgcagcag ccggtcccac acggcaggtt
      481 ggagcgtcgc ctcgatccgc ccctccatcc gcagcatcgt gaggttctgg agcagcatga
      541 acgcggccga cacgatgctg gtgaccatga tggccagaca gacctgcacg atcagtccgt
      601 gctgggcctt gggcacgtac tcgccgagca cctggccggt ggcgatcggc accagcgcgc
      661 cgatcgcgac ggtgacgaga ccgctgatcg cgaggttgcg caggtcgccg cccgtgccct
      721 ggaggcagaa gcgcagcagc cgcagcgggc tcagcttccg ctcgggcagc ggccggtaga
      781 acatcacggc ccgcgccccg aactccggcg cgttggcctt ctcgaccggg gtctcccgcc
      841 ccgaagacgg ctgtacggcc acgtatccgc cgcgccgcca cagcagcgcg accggggagc
      901 ccgacacggc gcggtggccc accagcgggc cgatgttgtc gcgccaccag cgcccgtcga
      961 ggcgtacggc acgggtgcgg acgcgcgagg cgagcgcgat ccgctccacc gggtcgagcc
     1021 ggtcgctctc cgtgccgctg tgcgcggact cggcgagggt gatcccggac gcgcgggcga
     1081 ccagcttgca ggcggcgtac gtggcgtccg cgtcggccgc cgtcgggcgc ttggacgact
     1141 tgccgatcga cgccagcagg gtccggtcgg cctgggcgcg gacggcctcg cccgccttga
     1201 tgcccgccgc cgtacggtcc tcgtggctgg cctccaactg ctcgatccag cggtcgagtg
     1261 tggacagcag ccggtactgc tggtcgacca tgccctgcca gacaccggag tccatcagca
     1321 gatcggccgc cgcctcggcg ccgtacaggg agccgtactg gacactcccg ggcggcacct
     1381 gcatccagaa gacgtcgtcg tcggtcagcg cggcggcgtt ctccgtggcc atcggcgcct
     1441 ggaagagaat ggacaggctg cgaccgacgc ctagggcgag ggcgtactcc agcgggctcg
     1501 acgtcggcgg tacgtactgg gggttgccgt agtcgtcgta ggaccaggtc tgggtgtcca
     1561 ccggctggta cagctcgcgc agcacgatcc ggcgcaccac acagtcccgc aacggccgcc
     1621 ccacgagggt gtgttgtggg cccgcgacgg ggccgagcag cagggagccc gcttcgaggc
     1681 ggccgaggtg gtgccagtgg ccctgctgga cggcatcgac cgcgaacagg tccatggcac
     1741 ccgccgccac cagccagagg acctgcggtc cttccagatc gaggcggccg aggccggagc
     1801 agtcgaccgg cgttcccatg ccgccgagcg cgccgaggac gaggtctccc tcgcgtgcgc
     1861 cctcgtgaac cgtggtcatc tcatcgctcc ttgaccagct cggcgtacgg accgccggcc
     1921 gccaccaggg cttcgtgccg cccgcgttct acgatcgtgc cgtgctgcag cacgacgatc
     1981 tcgtcgctgt cgcgcacggt gctgagccgg tgcgcgatca ccacacaggc gcagccgcgc
     2041 ttgcgcaggt tgtcgatgac cgtctgctcg gtctcggcgt ccagcgcgct ggtcacctcg
     2101 tcgagcacca ggatgctggg ccggcgcacc aacgcccgtg cgatctccag gcgttggcgc
     2161 tggccaccgg agaagttgcg gccgtcctgc tcgacccggc tgtggatgcc accggggcgg
     2221 cgcgtgacga cctcgtacag cgccgcgtcc tccaacgccg cgaccacggc ctcgtcgggg
     2281 atggacggat cccacagggc cacgttgtcg cggaccgtcc cctcgaagag gaacacgtcc
     2341 tggtcgacga aggagacgga ggcggcgagc gcgccgcgcg ggatgtcctc cagccgctgc
     2401 ccgtcgatgc ggatcgtgcc ctcccacggg gcgtacaggc ccgatatgag cctggagacc
     2461 gtggacttgc cgctgcccga gccgccgacc agggccacct gctggcccgg gccgaccgtc
     2521 agggagaagc cggtgagcag gggtttgtcg agcgggctgt agccgaacgt gatgttctcc
     2581 agctcgacat gaccctggag ccggcgggtg gactcgccgc tgccggagcg ggcgtagagc
     2641 gggtcggtct ggaagttctc gacgtccttg agccgggcca cgtcggcggc gaagtcctgg
     2701 atgcggccag cgacgccgtt gagccgggtg aggggcgcgg tgaagcgggt gaccagggcc
     2761 tggaaggcga cgagcagacc gacggagatg tgcccctcga ccgcccgcag accgccgatc
     2821 cacaggatca gcgcggagtt gagcgtcgcg agcgtcggtg cgaccacgcc cagccaggcg
     2881 ctcggcaccc cgaggcgctg ctgctcctcc agggtggtcg cgtgctgccc ggcccacttg
     2941 cggaagtagc cgtcctcccc gccggtcgcc ttcatcgtct cgatcaactg gagcccggtg
     3001 taggcggtgt tggtgaggcg cgcgttgtcg gcgcgcagct tcgccgtacg ggtggcgcgc
     3061 agccggatca ccacgcgcat cgcgatcacg ttgagcagcg cgacgccgat gcccacggcc
     3121 gtgagctgcg ggtcgtaggt gtagaggagc accgcgtaca ggacgaccac gatcgcgtcc
     3181 acgccggccg ccgcgaggtc ccgggccagg gtctcggcca ccgcgtcgtt cgactggagc
     3241 cgctgcacca ggtcggccgg gctgcgctgg gagaagaagg tgacgggcag ccgcagcaga
     3301 tggcgcagga agcgggcgct ggagagggtg gaggagatga tccggccgtg cagcaggttc
     3361 gcctgctgga gccaggtcag cacgacggtc agcgccacac aggcgcccat cgacgcgaac
     3421 agcacgccca gcaacgaggt ccggccgccg atgagatacg tgtcgatgta cgtccggctc
     3481 agcgcgggga ccgccgcgcc gaccgcgacc agcagcaggc tcgccagcac ggccgcgggc
     3541 atcgtgcccg aggtgccgcg cagccgggcc ggcatggcgc ccaggacgcc cggcttgcgg
     3601 ccgcccttgt ggaagtccgg ccccggctcc atgaccagaa ccacacccgt gaagctggtg
     3661 tcgaagtcct ccatcggcac gaaacggcgg cccttgccgg ggtcgttgat gtgcacgccg
     3721 cgccgtccga agcggcggcc catgccgtcg tagacgacgt agtggttgaa ctcccagaac
     3781 aggatcgcgg gcgccttcac ctcggcgagc gcggccgtgt ccatctgcat gcccttggct
     3841 gtgaggccgt aactgcgcgc cgccttgagc aggttgctgg cgcgcgagcc gtcccgggag
     3901 acaccgcagg cgatgcgcag ctcttcgagg gggaggtggc ggccgtagtg gccgagcacc
     3961 atggccaggg aggcggcgcc gcactccacg gcctccatct ggaggacggt gggggtgcgg
     4021 accgtcttgc ccttcgcctt ggggaccgtg cgcttgggcg gggcggtgcg gcgtctgctc
     4081 cgggtgtctg gtgcggtggt cacggcagga gccaatcgac ggggcgctga tcggccaggc
     4141 ggatcgaacc cgtggccagg gtcatggagg tgagcgcgaa cggcggcccg tcggccgagg
     4201 accacttcag gccgctcttc gtcgcggcgg agcggtcgag gcggaccagg acggccaccg
     4261 gcctgccctt cttggagaac tgttcgccga gttggctgtc accgaggaag gaggagatct
     4321 gctggggggt ctgcacgctc cggccgaccg ccttcacatg gccgcgcagt accccgtact
     4381 gctgggtcgg caccgactgc acggtgaggt cgaccgcggc gttcgcgggg atggtggcgg
     4441 cgctctcggc gggcacgtac accgtcgcgt agagcggatc gtcggcgtgg gcgaccttct
     4501 ccacggcggc gacgttcgcg ccggtcgaga tgatcgcgcc gatggtggcg gcgagcgcgg
     4561 tgacgcgtcc cgcggcgacc gtgcggacga cggtcgtacc gccctgggtc gtacggacct
     4621 tgagcaccgg cgcgttcgcg gcgagccgtt cgccctcctg ggcgacgacc tcggtgacct
     4681 gccccgcgac ggggctctgc aggatgtagc tgccctcgcc gtgggtgagg acggcgggcg
     4741 cgctcacggt ggacgccacc gtgcccgtca cggcccagac ggacgccgcc gccatgacga
     4801 ccaccgtcac ggacagggcg agccagccct gggggcgggc gaagcgcacc ggaaggtcga
     4861 gctcttcggg cgactgcagc ttggcgaggg cctgttggcg gaactgcacg ggacttccct
     4921 cacctgttcg agaggtttac ggcatccgag aagtcccgga accggggagt ggttccggga
     4981 ctcaacggca ctgaaagcga tcagagaccg gcgaccaggc ccgtgaccgg ggcggtgttg
     5041 aggccggtga caccctcgac ggtgccgaca accgtgttga ccaggccgga gaccggggca
     5101 acaccgtcga ccaggccggt gacggtgccg acggcgttca gcgacagacc gccggagacg
     5161 ttgtcgaggt cggcgtccga gatctcggcg gtggcaacct ggggggtgga gttcatgagg
     5221 gaacttccct tcgtatggat attcataagg gggagagcgg cccccctctg gggacagatg
     5281 acggccgcca ccgcgggggt gcggcacccg attccgggcg ctgtgcggcg cccgttcccg
     5341 gatgcctggc tgcgacctcc gcggtgcaac ggatcaaagc acgctcgcgg tgcgcgcatc
     5401 caatcaaccg gggctctcac ctgcggactt gagcgtggcc agggcccaac cgtgcaggtg
     5461 tgcgcacgtc tcggcagtca gttcttcaca tgctgcacgg cattgttccg tccccgcgct
     5521 tgtcgccccg cactcgaaag ggacagtccc accgcaatgg cgcggagggg ggcgcgcgag
     5581 tgtgcagatc tgctgtccac cgtgacgcgc ctgcgtattc gatgtgcaga ttccctgaag
     5641 ccaggattcc gttcctgccg gaagacggac cgtcaccgat cggtagcgca acgtgccgga
     5701 tccgccgctc actcggtgta atggcccgat tgcctggtat ttcatgggtt tggtcgagcc
     5761 aactcagctc ttttttaaac acagttgaac agccctcgcg gcccacgcgt atcaacaggc
     5821 atccaggcgc cccctagtca gccgccggac ggtggcctcg accccgtccc caggaggtca
     5881 aagagttgag tcacaaaagg attcccaagc gcaaggccgc catcgctgtc ggaggcgtcg
     5941 cggcgctcgg agcggcggct ctgctgctgc cccacgccaa cgcctcgcag accgacgcga
     6001 agggcgccgc tcctaagacg ctgaagtccg cggacgcctc gaacctggcc tcgctcctcg
     6061 cctcccagct cggtgacgcc ttcggcggcg cgtactggga cgcctcgaag cagcaggtca
     6121 tcgtcaatgt cgtcggcaac aacagcaatg tcgtcaacac cgtcgagaag gccggcgccg
     6181 ttccccgcag cgtcaacaac agcctgtccg cgctcaagac ggctgccaag acactgaagt
     6241 ccgacgcgac catccccggc accgcctggt cgatcgaccc caagacgaac caggtccagg
     6301 tcaccgccga cagcaccgtc acgggtgcga agtgggccaa gctgacgtcg accgtcgact
     6361 cgctcggctc cggcgtggcc acggtcaaga agtccgccgg tacgttcaag acgttcgtgt
     6421 cgggcggtga cgccatcttc gcccaggcga acggcggcgg cgtccgctgc tccctcggct
     6481 tcaacgtcac agcgagcgac ggcgcccccg ccttcctcac cgccgggcac tgcggtgtcg
     6541 cggccaagca gtggtcggac tcgcagaacg gccagccgat cgcgaccgtc gaccaggcca
     6601 ccttccccgg cgccggcgac ttctcgctcg tgaagtacga cgaccccgcc acccagacgg
     6661 tgagcgaggt gaacgaaggc aacgggaaga ccgtccagat cacccaggcg gcggacgcca
     6721 cggtcggtca gcaggtcctc cggatgggca gcaccaccgg tctgcacgac ggttcggtca
     6781 ccggtctcga cgccaccgtc aacttccaga gtgaaaccgt ccccggtggt gtcgacaccg
     6841 tcaccggtct catacagacc aacgtctgcg ccgaggcggg cgacagcggc ggctccctgt
     6901 tcaccgcgga cggcagcgcg gtcggactga cctccggcgg cagcggcgac tgcaccgccg
     6961 gtggcgagac cttcttccag cccgtgaccg ccgccctcca ggcgaccggc gcgacgctcg
     7021 gcgcgggtgg cgccgcgggt gccggcggtg cgagcgccgc ggcgaccgac ccggcggcca
     7081 ccgaccccgc ggccaccgac ccggcagcga ccgatccggc cgcgaccgac cccgcggcca
     7141 ccgacccggc agccacggac ccggcggcga ccgaccccgc ggccacggac ccggcggcca
     7201 ccgacccggc cgcgggcggc cagtccggga ccggcagcgg ccagtccagc accggtatga
     7261 acgccggctc cggcctggtg accagcaccc cgtgacaccg gtgaccacga gccactgacc
     7321 cggccgtgcc aacacggccc ggtcggcagt ggaagggtcc ggccctccgg cgggagggcc
     7381 ggaccccacc gtgtttcccc cgccgctcac gagagggccg gacgccgagg gtttccggtt
     7441 ccgctcagtc gtgcggacgc acccgcaaca gaagcagcgc cacgtcgtcg agccgctcct
     7501 gcgtcgccgc cccggtctgc tcgacgagac ggtcggccag cgcgttcagc gacaggtcac
     7561 cgccctcggc gagtttgcga ccgaggtcgg ccagggcgtc ctcgatgtcc acgccgggcg
     7621 actcgatcag accgtcggtg tacagggcga ggaccgaacc ggggacgagc ggcacctcgg
     7681 tcgtcggata cgtggcggcc gcgtcgatcc ccagcagtgg cccaccggcc aggtcgagca
     7741 cccggacccg tccgtccggc cgcagcagca gcgggggcgg atgacccgcg cgcgacatga
     7801 cggccacctc gcgcgccggg tcgagacgca gatagagaca gctcgcgaac agctcggccc
     7861 ccaggtcgat cagcagccgg ttggtgctgc gcatgacctc ctccggcggc tggccgacgg
     7921 tcgtgtacgc ccgtacggcc gtgcggatct gccccatcag gcccgccgcc gtcacgttgt
     7981 gcccctgcac gtcaccgatg accgcggcgg ccagaccgtg cgagggcacc aggtcgtaga
     8041 agtccccgcc gatctccatc ccctgagtgg ccgggagata gcgcgcggcc gcctcgatcg
     8101 agggcagcgt gggcaacgag tgcggcaaca gcgcggcttg cagaccatgc gccagctgca
     8161 gcttggcgtc gtagagcagg gcccgctcca gggcctgcgc gatcagaccg cagaggctgg
     8221 tcagtacggc acgctcctcc gccgggaagg tgtgcggttc cgcgtacccg aggacgcagg
     8281 tgcccaccgg ccgtccggac gcgatcagcg gcagatacgc ccacgccgcc atcccgtcgg
     8341 gcgtcgcgct ccggtccggg tagaggcgct ccagctgctg acgggagtcg aagaacgccg
     8401 gcaccccggt cttgagggcc tgggtgcccg gagtctgcgc gctcagtggc accccgtgcc
     8461 agcgctccac gatgtgcgcg tccgcgtaac cccggtggcc gagcacgtgc aggcggccgg
     8521 atcgcgagcc gaggacgacc agggccttgc tgccgacggc cggcgcgatc tcgtccgcca
     8581 ccagctgcac cacgtcctcg acccccgccg cctgggtgag cgcgcccgcc agactcagca
     8641 cctggctgat ggtcaccagg cgcggggtgg tgtcgtcctc gccgtgccgc gactcgacgc
     8701 gccccatctc ggccaccgcc cgggcccggg agatgcgcac gctcaggccg gtcgtattcg
     8761 gatagagccg gaacgacagc cagttgccgg gcggccgcag cgccacgaac gacgtcacgt
     8821 gctggctgat cagcgcggcc cggtaacggt cctcgtagac ggggtcgttg agccagggca
     8881 ccgacgccca cagctgggtg cccagcagct cgctgaccgg gacgccgagc atgtccgccg
     8941 tcgcggcgtt ggcgaaactg acccggccgt tcaggtccag ggcacacagc ccgtacggca
     9001 accgcgccac catccgcgcc gcctccagcg tgccgagcac gccggtggcc ggagccgcgg
     9061 acggagccag cagatccggc tcgggatgga ccggccgccg ctccgccgcc gcccgctcca
     9121 gacgcagcgc gagccgggcg caggacgcgg tgagatggtc acgctcccgg tcggagaggt
     9181 ccacgggatg cgagccgggc caggtcacga agacggcgcc gtacacggtg cccgcggtcg
     9241 ccaccgggag ggcggccagc gcgaaggggt acggcaggac cacggcgatc cgggggaagc
     9301 ggcgggccat ctcctcctcg ccaccgaccc agaccagccg ccgctcgcgc accgccaccg
     9361 cgaccgggat cggcgcgttg agccccaccc gctcccacgg cgccgcgaac gacctgggca
     9421 tgcccgccat gaccgccatc tccagcacgg cctcacccgg cgtcagcagg tacaccgccc
     9481 cggagtgggc gtggacctcc tccatcatcg aggccagcgt cagcgacagc agcggccgcc
     9541 cgaccggcgt ccgccgaccc gccggcgcct gtacggaccc ctgccagtcg gacacgccga
     9601 ccacctcctc gcagggccgc gcgacgggac tcagggatca aggctccctc gtgacggccc
     9661 ttcccgcacg gcgaacgcca cgcgcggcac agggtgccgc ttgcgggctc cgccgcaggc
     9721 ccgacggccc cggaaccgtc gcaggggctg cgcgagcgtc ccggaagcgc tgtaattgcg
     9781 gacgtggtca gtgagggcgc tgcggaacgc ggaaagagga cgttgcgtgc cgaacttgct
     9841 ctcaagacgc ccaccccgga cctggacccg cgcgagcgac agcgccgcgt gctcgaactg
     9901 gcactcgtct tcgcgggtgc gagcgtcgtc gcggtgtact cgcccaccga gagcggcgac
     9961 gagctgtacc tgtccgagtc ggcaggcgtc cccaggacgc tctacggcct gcgcgacagc
    10021 tatgtcctca ccggcggctc cccggcggtg gacgcgtacc gctcgggccg accgctgtgg
    10081 ctcggcccgg cggagatcgc ccactgcgcc gaagcccgca ggctgccgtc ccaggacttc
    10141 tggctggccg tcctgcccct gccggacggc ggctgcctcg tggcggccgg cgagcgcccg
    10201 ggcggcttcg acgagg
//
