LOCUS       NZ_CP041604            22830 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. S1A1-7 chromosome.
ACCESSION   NZ_CP041604
VERSION     NZ_CP041604.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S1A1-7
  ORGANISM  Streptomyces sp. S1A1-7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 58.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007113565.2-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 04:07:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,902
            CDSs (total)                      :: 10,801
            Genes (coding)                    :: 10,337
            CDSs (with protein)               :: 10,337
            Genes (RNA)                       :: 101
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 80
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 464
            CDSs (without protein)            :: 464
            Pseudo Genes (ambiguous residues) :: 0 of 464
            Pseudo Genes (frameshifted)       :: 185 of 464
            Pseudo Genes (incomplete)         :: 374 of 464
            Pseudo Genes (internal stop)      :: 46 of 464
            Pseudo Genes (multiple problems)  :: 127 of 464
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:07:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9420152
            Orig. end                         :: 9442982
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041604.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041604.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22830
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="33"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22830
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22830
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12830](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12830
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            709..1602
                     /locus_tag="FNV64_RS43205"
                     /old_locus_tag="FNV64_43815"
     CDS             709..1602
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996483.1"
                     /locus_tag="FNV64_RS43205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43815"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_143656210.1"
                     /transl_table=11
                     /translation="MAHDHHDHENAQHAHDHTHMDFAEMIPMLEQEAELFSPLYTEAAG
                     WLRDQRSETGLIVDAGSGPGVISCLLADTFPAARVVAVDEVEPLLERARARADRLGVGD
                     RFSTLRAELGGGLGDLEYPADLLWASRSLHHVGDQRAALAGFARALAPGGSLALMEGGL
                     PMRYFPREIGIGRPGLQSRVDAVHDEWFGRMRDELPGAVRETEDWAALMTAVGLRHTAT
                     RTFLVDHSAPVSDETRAFVVTSLTHRRDFLAPGLDADDLATLNRLLDPDDKASVYHRPD
                     VFLLTAHTVHVAVKPE"
     gene            complement(1639..3027)
                     /locus_tag="FNV64_RS43210"
                     /old_locus_tag="FNV64_43820"
     CDS             complement(1639..3027)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092238.1"
                     /locus_tag="FNV64_RS43210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43820"
                     /product="glycosyltransferase family 39 protein"
                     /protein_id="WP_240363536.1"
                     /transl_table=11
                     /translation="MYAPALLSLALGLWGVRRGGTLWRDEAVTYDMARRSLPDLWSTLA
                     DADAVHGLYYLLMHLLFEVTRGLDPLLVLRLPSVLATAAATGTLALLGHRLAGPRAGLL
                     AGSVFALLPQVQRYAQEGRSYAIVCALVVWATYLLVRAVASPDGRTWVAYAAVLVAAGL
                     LHEFAVLALTAHAVAVPRAARRAWAGAAAVVLVTVAPLAVLSTRQSDQVSWIGRPGAGA
                     LVGFAGTAVLALACAAMGRKPTSRVLRGVRLPVLALGLLVLPALLLLLVSLVTPLYVDR
                     YVLYGQSGTALLTGAALARLTRARRTRAAALTCAGAAVLALLPVTLQLRTPQSRVDDVG
                     AIARAVAEAGAPGDGVLYLPARRRVWSLPDPGALRGLRDLALDRAPAASHTLYGTEVPA
                     PVVRARMITASRIVAVSDPAGQPLDATPGEIVKRRVLATYFEKCGTRRVQGARVTVYAR
                     PGTC"
     gene            3283..6888
                     /locus_tag="FNV64_RS43215"
                     /old_locus_tag="FNV64_43825"
     CDS             3283..6888
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="FNV64_RS43215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43825"
                     /product="hypothetical protein"
                     /protein_id="WP_143656211.1"
                     /transl_table=11
                     /translation="MGRREKPLDPAQGAVARFAFELRGLRDEAGAPTYRAMARRAGYSG
                     PTLSAAAAGERLPTLPVLLAYVSACGGDTSVWERRWRAALAEEAGTPAPDDAEGPYPGL
                     ARFEPADRDRFHGRDDLIAELLRLVGRRRVSAVVGASGSGKSSLLRAGLIPALRTSAGT
                     REAEPAAAARTRASLPGQRRSPAAEFGTTATEPAPPAVPLSATHPPAPAAIRILTPGAH
                     PARTHGALFVPHDAPGDTLLVIDQFEELFALCADPGERALFIERLLTALDPDSGLRVIL
                     GVRADFYGRCAEHGPLAEALRDSTLLVGPMTPQRLREAVVRPAVARRVVVERALTARIV
                     ADVADEPGGLPLMAHALRELWRRRSARTLSLATYEAIGGVQGAVAHTAEEVYARCTPVE
                     AAAVRALLLRLVNPGDGAEDTRRPVLRDELGDADTTARVLEQLVRARLLTVDGDTVDLA
                     HEALISAWPRLRGWVDEDRERLRLHRRLTEAARTWQQLDRDAGALYRGVRLTAAREEFG
                     SRLGELSRLERDFLAASVTAYEAGRRTAARTARRLRSLTVSLAVLLCLAVVAGATAWRQ
                     SGVSARQRDEARARRVAAFADTLRPTDPRTAMRLALAAWRTADLPETREAVRTAAAQSD
                     QAAFTEPAQLGAPDAPHWLGADGRILTTVVRDKVVQWDVRRQRHLREVALPGLSEGIVD
                     VSADARWIAYRGRDGATVRNLTNGESHRVAPGSWTDTGGAFGPSGRTFVVRREGRGAGD
                     EGATVEVWDVRRERVLFRYPGGDRDGPLPVLSPNDRFLAWCTHDGERLRVWDVVERRRV
                     ATEPPARTQRLLCRSDEPVFTPDNRALAAGTADGVVTWDFHADRGRPLLPMPGEDVNSV
                     EFDPTGAYVLTWGSAGLALWRTDSPAPTDGGPRRPLITFPVETPAVTDIRLDPREGVLR
                     YREGSRAGVVRTLSLHGLIGTGWRNRARTDAAFDAYGQPAEPAVRPAVRAVAADGTVHT
                     AVSTRDGILVTRQGAHPVSHVVGRRSEGPAAIDPAGRTVVTAEGVLIDVATGGRRQGLQ
                     GEDLLPTAVFSPDGRYLAAADTQGRLTLWDAGGQHRIAVLAAADSTVERPALAFSADGS
                     LLAASRADGSVRVWETASPRLEGATLPTGDGPVLAIGFAPGAKELYVATPHLPLRSEQL
                     MPERAAGEVCARAGGGATRAEWRRYLPDVPYRRTC"
     misc_feature    3727..3729
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6974..7675
                     /locus_tag="FNV64_RS43220"
                     /old_locus_tag="FNV64_43830"
     CDS             6974..7675
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-167). E-value: 3.3e-08. Score:
                     25.6. Matches aSDomain:
                     nrpspksdomains_FNV64_RS43220_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922768.1"
                     /locus_tag="FNV64_RS43220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43830"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_054230068.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.8e-05,
                     bitscore: 23.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSPVALITGGGSGIGAAVARRLLDAGHRVTVTGRGEDRLRAFA
                     EELGRPQGLLTVVGNAAEYDQVRAAVELTLKEFGRLDTVVANAGFATHDTVAGGDPAGW
                     SEMVLTNVLGPALLIRASIDALKETRGRIVLVGSVAGHVHTPGNIYGATKWAVTGLAEN
                     ARREVTEFGVGVTLISPGRVETPFWDSYGSLPPGHLLTADQLAESIVWAIGQPSGVDVN
                     TVVVRPIGQPN"
     aSDomain        6989..7474
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FNV64_RS43220_PKS_KR.1"
                     /evalue="3.30E-08"
                     /label="FNV64_RS43220_PKS_KR.1"
                     /locus_tag="FNV64_RS43220"
                     /protein_end="167"
                     /protein_start="5"
                     /score="25.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGGSGIGAAVARRLLDAGHRVTVTGRGEDRLRAFAEELGR
                     PQGLLTVVGNAAEYDQVRAAVELTLKEFGRLDTVVANAGFATHDTVAGGDPAGWSEMVL
                     TNVLGPALLIRASIDALKETRGRIVLVGSVAGHVHTPGNIYGATKWAVTGLAENARRE"
     CDS_motif       6995..7063
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FNV64_RS43220_0001"
                     /evalue="9.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="FNV64_RS43220"
                     /protein_end="30"
                     /protein_start="7"
                     /score="15.2"
                     /tool="antismash"
                     /translation="LITGGGSGIGAAVARRLLDAGHR"
     gene            complement(7731..8426)
                     /locus_tag="FNV64_RS43225"
                     /old_locus_tag="FNV64_43835"
     CDS             complement(7731..8426)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073097.1"
                     /locus_tag="FNV64_RS43225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43835"
                     /product="glycoside hydrolase family 75 protein"
                     /protein_id="WP_143628909.1"
                     /transl_table=11
                     /translation="MRSRTLTLAAVAGAALLATAALPASASGSVTPRSAQEGSVSAADL
                     LAKVTSCSQISNGKYKTDDETSATIPVCGKNGAVFWKADMDIDCDGQVTGKCNGNADPW
                     FQDDTAFHQSDGKPLRAESLPYVVVPSTSSIWKYTSYGIKGGGVVAVIYNNKVEYAVVG
                     DTGPTKIIGEASYATAKALGIDPDPATGGADSGVTYILFKNSQVSPIESHSAAVSLGDS
                     LAKRFLQNN"
     gene            complement(8672..9463)
                     /locus_tag="FNV64_RS43230"
                     /old_locus_tag="FNV64_43840"
     CDS             complement(8672..9463)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191514.1"
                     /locus_tag="FNV64_RS43230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43840"
                     /product="aldo/keto reductase"
                     /protein_id="WP_097289315.1"
                     /transl_table=11
                     /translation="MPQLGFGVWQVPDDEAEQAVATALESGYRSIDTAAIYGNEEGTGK
                     AIATSGIPREELFVTTKLWNSDQGYDSTLRAFDTSLEKLGLDYLDLYLIHWPLPSRGKY
                     IDTYKAFEKLYTDGRIKAIGVSNFYPEYLEQLIEATSVIPAVNQIELHPHLQQHATREY
                     HAQQGIATEAWSPLGSGKGLLEVPAIVAIAQKHNRTPAQIVLRWHIQLGNVVIPKSVTP
                     SRIKENIDVFDFSLDTEDIAAISALNEDRRLGPDPATFDMG"
     misc_feature    9640..9655
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    9715..9730
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            9788..9982
                     /locus_tag="FNV64_RS43235"
                     /old_locus_tag="FNV64_43845"
     CDS             9788..9982
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV64_RS43235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV64_43845"
                     /product="hypothetical protein"
                     /protein_id="WP_143603463.1"
                     /transl_table=11
                     /translation="MNKSALEGRRAEQVIRETSEESVWETPGYLVVETALEVTAYALGD
                     RLGPVTERATAGPHLARTA"
     gene            10001..>10711
                     /gene="pqqC"
                     /locus_tag="FNV64_RS55630"
                     /pseudo=""
     CDS             10001..>10711
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559516.1"
                     /locus_tag="FNV64_RS55630"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /pseudo=""
                     /sec_met_domain="TIGR02111 (E-value: 3.9e-83, bitscore:
                     277.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPVRDDGAAAPWGTAEFTERLRAIAEDRYHDRHPFNVRMHQG
                     ELTPAELRRWIINRFHYQRHIPVKDALILAKFDDPALRRVWVRRIQDHDGTAVGRGGIE
                     RWLRLGEAAGLERPALWDTARVLPGVRLAVEGYVNFCRLRPVLDAVAASLTELSAPGLM
                     RTRIAAFERYYPWIEAAGLAYFRTRIGQGGRDSEEALALVQGWARTREQQERAVAALTF
                     KCEVLWALLDAVDRA"
     gene            11494..11748
                     /gene="pqqD"
                     /locus_tag="FNV64_RS43245"
                     /old_locus_tag="FNV64_43855"
     CDS             11494..11748
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645346.1"
                     /locus_tag="FNV64_RS43245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43855"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_060897071.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.5e-19, bitscore:
                     66.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.5e-11, bitscore: 41.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRPVLAHTVMLRHDPVRDTDLLLMPERVVVLRGHAGSVVRLCD
                     GRREVPEIVAALAERFPGAPVADEVPRFLSALHEEGWLR"
     aSDomain        11503..11742
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FNV64_RS43245_PqqD_RRE.1"
                     /evalue="2.00E-21"
                     /identifier="RREFam006.1"
                     /label="FNV64_RS43245"
                     /locus_tag="FNV64_RS43245"
                     /protein_end="83"
                     /protein_start="3"
                     /score="66.5"
                     /tool="antismash"
                     /translation="RPVLAHTVMLRHDPVRDTDLLLMPERVVVLRGHAGSVVRLCDGRR
                     EVPEIVAALAERFPGAPVADEVPRFLSALHEEGWL"
     gene            11745..12830
                     /gene="pqqE"
                     /locus_tag="FNV64_RS43250"
                     /old_locus_tag="FNV64_43860"
     CDS             11745..12830
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="FNV64_RS43250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43860"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_097286911.1"
                     /sec_met_domain="PF04055 (E-value: 2.8e-23, bitscore: 82.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-06, bitscore: 27.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.1e-05, bitscore: 25.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.5e-09, bitscore:
                     35.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTVDPPWALLAELTHGCPLRCAYCSNPVELISRSRELTAEQWA
                     DVFHQAADMGVVQTHLSGGEPLLRRDLARIVAAADTAGLYTQLVTSGVALHERRLAELL
                     DAGLRSVQLSVQHTDAQAAERIAGARAFTAKERAARLVRATGLPLGLNVVLHRANIDAV
                     DDLITLALTWGADRIELAHTQYYGWAARNRAALLPTRDQVEQARVTVRRRRGQLAGSLE
                     LVWVAPDLLDATAKPCMGGWGAVSLTVAPDGTALPCPSAATLPALDAPNVRAHRLDWIW
                     RESKAFNAYRGEAWMPDPCRGCALRTTDFGGCRCQAYALTGDASRTDPACRHAPDHHLV
                     RALVDEAPLRNSAYAYREGGT"
     gene            12827..14026
                     /locus_tag="FNV64_RS43255"
                     /old_locus_tag="FNV64_43865"
     CDS             12827..14026
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382297.1"
                     /locus_tag="FNV64_RS43255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43865"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_054230073.1"
                     /transl_table=11
                     /translation="MRRRLRAALMAGVLTTAGLTTVAATAPPTPLPRGPVGRPAAAQDW
                     SVALIDSTMARYTPSTIGGWSYPVGLYLYGQYLTYQRTHDARYLTYIKSYVDRFVSSDG
                     SIGQSFNSLDSMQAGRLLTILHHETGQDRYRKAALKIRNRLNTYPRTSDGGFWHADTSS
                     RAHQLWSDGVYMVNPFLVEYGKEFGDATYANDEAAKQLYVYGNHLQVASGLLKHAYDES
                     KTASWADPATGLAPEHWCRAVGWYAMAIVNVLDAIPVNHPRRPQLVGIFRRLAAGLEKY
                     QDPATGRWFQVIDKGARGDNWTETSCSSMFTYALSRGAQQGYLDPHYASVAQRGYQGVL
                     ARMSVGSDGRTNLTDISIGTNVGDYAYYIARDRATNDFHGLGAFLIMNEQLTAHPLRTR
                     "
     misc_feature    12917..12919
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14034..14825
                     /locus_tag="FNV64_RS43260"
                     /old_locus_tag="FNV64_43870"
     CDS             14034..14825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482488.1"
                     /locus_tag="FNV64_RS43260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43870"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_143656213.1"
                     /transl_table=11
                     /translation="MSTTRRTLFGAALGGAAGAAVGIPATVTAAHAASWQLKWSPSASG
                     DKLGAFETIEDDRADSHPAGRPHIFATGDNWRFNMHTVDRDTSTDRQRQEVTGLRTSAG
                     SYLKWTAGQTWRLTYSMYIPSSLKATTTFTHIMQMKQPGTGTSPIVVQSLRRVNGVQTI
                     ELKLAIDDILIGRTDLDPLHDKWTDVDFQIKVGDGTSGSVRWILKSGSTTIIDKSRTGV
                     DTFLADRVRPKWGIYRSLGDTSGSLQDCYLLLTNLRGYQLV"
     gene            14837..20332
                     /locus_tag="FNV64_RS43265"
                     /old_locus_tag="FNV64_43875"
     CDS             14837..20332
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141318.1"
                     /locus_tag="FNV64_RS43265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43875"
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_143656214.1"
                     /transl_table=11
                     /translation="MKPPMRKRSWAASVFFAFAVVLGLTHPEALAAPRTATPPTSTTAP
                     TSTTAPHAAVFDVHDYGAKGDGSTNDTPAINKAITAANAAGGGTVRFPAGQYKSKNTIH
                     MKSEVTLQVDKGATIQGSSADTYDPPEANPNDAYQDYGHSHFHNAMIYGDRLTHIGFVG
                     EGVIDGLGNLITGNPKSGEADKILSLTRCDGLRLGDGLTLRRGGHFAALINGCTNVTSD
                     HLTIDTASDRDGWNIISTTNVTVTNANIKANDDALVFKSDYALGAKLPNGHVRVSDSYL
                     SAVCCNALMFGSETCGDFSDYQFAKIRIEGSNKSGLGMVSMDGAKISDVHYRDITMTGV
                     HSPIMQKIGTRKRCGNSPGVGSISDVTYDNITATGVSPSFSPTLWGESGHRINGVTFTN
                     VDITVPGGNGTMSTAVPSNDPGDYNPKAIGTRPAYGWYVHNADNITFTDSSVKYAADDG
                     RPAVIANAANGIRFTRFTAQRGSNSPHDMGFQNVTGYCLTDSHNTSGGALRVSAGGSSE
                     NCATPAKSTTMASTAVQRPHTGGKPLDLENPRQAFLRGSVGGLFLHWGERTAPAHTSCT
                     AWENDVTNGGWTPDYWVNEAQKLHTQYLVLATFHSRLGYARPWPSKIPGSCSTKRDFLG
                     ELITAAKAKGLKVILYMTDDPQWHNEGGHEWLDSAAYSAYKGTDVDLTTRDGFGRFSYD
                     NFFEVMDRYPDLGGFWIDNDNAYWESHDLYAQIQQKRPNYTLSNNNEDTPIMDMISNEQ
                     KTGMTPSYDYPQAVYTAQPRLTEADFKLPSSGAWWYDGSNPSVDKMLTLGRLITNAGSS
                     VKALMAETAQVNGKFPTNQEAFNNFANSYLGPIWQSLHGTEGGGYMYGGLKPGFWNDGA
                     HGVTTVSKTDPDLQYIHVLTPPSTSTSTLRIRDNGYRIASVTNLRTGAAVSWSQSGGVL
                     TLTGLANWDPYDTVFKVTTAGRQGIASGVTMSASASASGHGAAAAGDGDYLTYWDSNKT
                     LPVNLTFDLGSARKVQYIGLNQREDSVAYARSDTEQSARIKDYKVFLSNDGSTWGSAVK
                     TGQLASRRGIQGIDLTAANARYLRLEVDTTWAASTDTTRYKRLRIDEAWIGTSYATPAA
                     TVNTYSDNGQALRPAMGWSSWSFVRRWPTEAKIKAQADALVASGLKDHGFVYINLDDFW
                     QKCDANGFVVDSYGRWTVDTAKFPAGIKALADYIHSKGLKFGFYVTPGIAKNAVTRNTP
                     IEGTSYHAADIADTSKTEKNYNCKNMYYIDYGKPGAQEFVNSWAKQFASWGVDYLKIDG
                     VGSADIPDVQAWDKALRATGRPITFALSNNLPIAGASTWKSLANSWRTQGDVECYCGSG
                     ANGSGYPLTDWSHVSARFTSAANWQQYAGPGGWNDLDSLEIGNGDQAGLTADQRRSHFT
                     LWAMAGAPLLLGTDLTNLDSVDKPMLTNDRLIGVDQDGVAAKRIVNSGVKQVWSKKESD
                     GQYVVALFNTGTSGNTTVGVNWSQVGFTGSGDVTDLWSGSHKGTIADSYSATLRPGETR
                     LIRVKPVSAALKTAAASPGMAVAPYEYLGWGSPQNPTSVMSATGVKWFTLAFVLSDGSC
                     NPKWDGSRPLTGGNDQSKINAIRAAGGDVVVSVGGWSGAKLGEKCSSASALAGAYQKVV
                     NAYGLKVIDIDIENTEWSNATVRQRVIDALKIVKAGHPGLKTIITFGTTTSGPDSTGVD
                     MIKRGAASGLANDIWCIMPFDFGGGTTNMGTLTTQAMEGLKARVKSAYGYSDATAYAHI
                     GLSSMNGKTDDSGELVRVADFKTMLAYAQQHHIGRLTYWSVNRDRACGSGSDGDSCSGV
                     SQQPYDYLKVFAQYTG"
     gene            20345..22372
                     /locus_tag="FNV64_RS43270"
                     /old_locus_tag="FNV64_43880"
     CDS             20345..22372
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141320.1"
                     /locus_tag="FNV64_RS43270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_43880"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_143656215.1"
                     /transl_table=11
                     /translation="MKLNRTLPWCLSLVLAVPLVALTGTAAQAATDYQAEDATISQGAV
                     ATNHTGYTGTGFVDYTNITGSYVEFTVSAATAGTSSLALRYANGTTVDRPMDLSVNGTV
                     VASGVSFPATTDWNTWATKSVNVPLDAGSNKIRATATTANGGPNLDRVSVGTAADTQAP
                     SRPGQPSCSAIGEDGLTLSWGASTDNVGVAAYDLYEHGNKLGEAAGDATSKVLTGLSPN
                     TTYNLTVIARDAAGNASQASPVVDCTTRPSSDTTPPGKPGTLTSSNVTATSADLSWGAS
                     TDDKAVVGYDVRSDTTVYKSVTGTSTTLTGLACNSPYTLNVVARDAAGNVSPQSNTVTF
                     TTKACATDGGVPSSIGTVSSGWTIPWGTYWMPDGQTALVTERDDFRVWKVTKDGTRTQV
                     GTVPNAVTTNGEGGLLGVAVDPKWATNHYVYFMHTASEGNRVVRMTYDGSSLTDYTILL
                     QGIKKNRYHNGGRLAFGPDGYLYVSTGEAQTPDLAQDKTSLNGKILRMTTDGKAAPGNP
                     FGNYVYSYGHRNPQGLAFDRNGRLWEAEFGNSSKDELNLIKPGANYGWPTCEGSCSVSG
                     MTNPKATWNVSEASPSGIAIVRNVVYMASLRGERLWRIPITGDTENVGTPTAYYVGTYG
                     RLRTVTKVPGADQLWLSTTNCDNNGGAADGSDKIFKVSIN"
     misc_feature    22545..22559
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     misc_feature    22756..22769
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.35"
                     /tool="antismash"
ORIGIN
        1 gcgagcgggc ggtgcgcgga ggcctcggcc accttcggac cgagttcgag gaacgaggcc
       61 cccgcctcgc cgtacggctc caggaccggc ggcacgtcga ggtgcgagcc caccctgata
      121 cgggtcgggg cgtcggcccc ggtcacctcg ctgaacagga agagcatcag cagggcccgg
      181 ccccgcgagc ggagattgga gtggtagagc gcctcaccgt cggggaggta actgccttcg
      241 atgtgccagc ccgcgtcgtc cggctcctcc gtgtgcggga accgcagcgg gaaactgccc
      301 agcgcgtagc gcggctccca gcgtctctcg ccgaccagca gatcgaaggc ctggtgcaga
      361 gcgggggagt tggccgcggc ggcgaacggg ccctgcgcca tgctgctcac ccagtgcacg
      421 gggtccttcc aggtgccggg gtcgtccggg tcgtaccccg tctccttcca cagcagccgg
      481 gcgcagctct cggcgacgcg cggcgggaag gcgccctcga tcttcacgaa cccgtcctcg
      541 aggaaccgcg ccaccatctc gtcgtccatg gggccatgct cggggacgga ccgcctcgga
      601 cgcatcagat tttccgaccg cggtttttgc tgttcgcgca acatcgttgg ccgtttccgg
      661 gagccgagga gcacgctgtg tacgcacccg gacgagaggc ggaccaccat ggcacacgac
      721 caccacgacc acgagaacgc ccagcacgct catgaccaca cccacatgga cttcgccgag
      781 atgatcccca tgctggagca ggaggcggag ctgttcagcc cgctctacac cgaggcggcg
      841 ggctggctgc gggaccagcg gtccgagacc gggctgatcg tggacgcggg cagtggcccc
      901 ggtgtcatct cctgtctcct cgcggacacc ttccccgcgg cgcgggtcgt ggccgtggac
      961 gaggtggaac ccctgctgga gcgggcccgc gcccgtgccg accggctcgg cgtcggcgac
     1021 cgcttcagca ccttgcgggc cgaactcggc ggcggactgg gtgacttgga gtacccggcg
     1081 gacctgctgt gggcgagcag gtccctgcat cacgtgggcg accagcgcgc cgcgctcgcc
     1141 ggtttcgcgc gcgctctcgc gcccggcggc agcctcgccc tcatggaagg cggcctgccc
     1201 atgcgctact tcccgcgcga gatcggcatc ggccgccccg gccttcagtc ccgtgtcgac
     1261 gcggtccacg acgaatggtt cggccggatg cgggacgagc tgcccggagc ggtgcgagag
     1321 acggaggact gggccgccct gatgaccgcc gtcggcctgc gccacacggc gacccgcacc
     1381 ttcctcgtcg accactccgc cccggtctcg gacgagacgc gcgccttcgt cgtcacctcc
     1441 ctcacccacc gccgcgactt cctcgccccc ggcctcgacg cggacgacct cgccaccctc
     1501 aaccgtctcc tcgacccgga cgacaaggcg agcgtgtacc accggccgga cgtcttcctg
     1561 ctgacggcgc acaccgtgca cgtcgcggtg aagccggagt agttccggcc ggtccgcatc
     1621 cggagtggtt ccggccggtc agcacgtgcc cgggcgcgcg tacacggtga cccgggcgcc
     1681 ttggacccgg cgtgtgccgc acttctcgaa gtacgtggcc aggacccgcc gtttgacgat
     1741 ctcccccggg gtcgcgtcga gcggctgccc cgcgggatcg ctcacggcga cgatacggct
     1801 cgccgtgatc atgcgggcgc ggacgaccgg cgccggaacc tcggtgccgt acagggtgtg
     1861 cgaggcggcc ggtgcgcggt cgagggccag gtcccgcagc ccgcgcaggg cgccggggtc
     1921 gggcagggac cacacccggc gccgcgccgg caggtagagg accccgtcac ccggcgcacc
     1981 ggcctcggcg acggcccggg cgatcgcgcc cacgtcgtcg acccggctct gcggtgtacg
     2041 cagctgcagg gtgacgggga gcagcgcgag aacggcggcg cccgcgcagg tcagcgccgc
     2101 cgcgcgggtc cgccgggccc gggtgagccg ggccagcgcc gcgccggtca acagggcggt
     2161 gccgctctgg ccgtagagga catagcggtc cacatacagg ggtgtgacca gcgagaccag
     2221 caggagcagc agggcgggca ggacgaggag cccgagcgcg aggacgggca gccggacgcc
     2281 ccggagtacg cgcgaagtgg gcttccggcc catcgccgcg caggccaggg cgaggacggc
     2341 cgttcccgcg aaccccacga gtgctccggc gcccggtctg ccgatccacg acacctgatc
     2401 cgactgccgc gtactcagca cggcgagcgg cgccaccgtg acgaggacca ccgccgccgc
     2461 cccggcccag gcccggcggg cggcgcgcgg cacggcgacc gcgtgcgcgg tgagcgccag
     2521 tacggcgaac tcgtgcagca gaccggccgc caccagcacc gcggcgtagg cgacccaggt
     2581 gcggccgtcc gggctcgcca ccgcccgcac cagcagatac gtcgcccaga cgaccagcgc
     2641 gcacacgatc gcgtacgacc ggccctcctg cgcgtagcgc tggacctgcg gcagcagtgc
     2701 gaagacggat cccgcgagaa gacccgcgcg gggtccggcc agccggtgtc cgaggagggc
     2761 cagcgttccg gtcgccgcgg cggtggcgag gaccgacggg agccggagca ccaggagcgg
     2821 gtcgagcccg cgggtgacct cgaacaacag gtgcatgagc aggtagtaca gaccgtgtac
     2881 ggcgtcggcg tcggcgagtg tcgaccacag gtcgggcagg gaccgccgcg ccatgtcgta
     2941 ggtcaccgcc tcgtcccgcc acagggtgcc gccgcgccgt acgccccaca gcccgagggc
     3001 gagcgagagc agggcggggg cgtacaccgt cggtggggtg tgcggggcgg gcgtcggcaa
     3061 ccgtgcgggg gcgagcggcg gtctggaagt gtgtgtggtg gcgatggctg actccggcgc
     3121 gtggtcgatg cctcgcggtc ccctccgacg gggccccgag gacgtgcacc gtcgagtcca
     3181 gccgccggac gattgatggg cagccccgtc gcggagcacc tatcaatgca ggtggggagc
     3241 ggtgccgacg gatcgggccg ccgcggacgg ggggagtcac cggtgggacg ccgagagaag
     3301 ccgctggatc cggcgcaggg cgcggtggcg cggttcgcct tcgagctgcg ggggctccgc
     3361 gacgaggcgg gcgccccgac ctaccgcgcg atggcccgcc gggcgggcta ctcgggaccc
     3421 acgctgtccg cggcggcggc gggcgagaga ctgcccacac tgccggtgct cctggcgtac
     3481 gtcagcgcgt gcggagggga cacctccgtg tgggaacggc gctggcgcgc ggcgctcgcg
     3541 gaggaggcgg gcacccccgc accggacgac gccgagggcc cgtaccccgg actcgcccgc
     3601 ttcgagcccg ccgaccggga ccgcttccac ggccgcgacg acctgatcgc cgaactgctg
     3661 cgactcgtcg gccgcaggcg ggtgtcggcc gtcgtcggcg cctcgggcag cggcaagtcg
     3721 tccctcttac gggcggggct gataccggcg ctgcgtacat cggccggtac gagggaggcg
     3781 gagccggccg ccgcggcgcg gacgcgcgcg tcgcttcccg gacaacgcag gtcccccgcc
     3841 gccgaattcg ggaccacggc caccgagccc gctccgcccg ccgtcccgct gtccgccact
     3901 caccctccgg cccccgccgc catccgcatc ctcacccccg gcgcccaccc ggcccgcacc
     3961 cacggcgcgc tgttcgtccc gcacgacgcg cccggcgaca ccctgctcgt catcgaccag
     4021 ttcgaggagc tcttcgcgct ctgcgccgac cccggtgaac gggccctgtt catcgaacgg
     4081 ttgctcacgg cgctggaccc ggacagcgga ctgcgcgtga ttctcggggt ccgcgccgac
     4141 ttctacggac ggtgcgccga acacggcccg ctcgccgagg cgctgcggga ctccaccctg
     4201 ctcgtcgggc cgatgacccc gcagcggctg cgcgaggcgg tcgtccggcc ggccgtcgcg
     4261 cgacgggtcg tcgtcgaacg cgccctcacc gcacgcatcg tggcggacgt ggccgacgag
     4321 ccgggcggtc tgcccctgat ggcccacgcg ctgcgcgagc tctggcggcg ccgcagcgcc
     4381 cgcaccctct ccctggccac gtacgaggcg atcggcggcg tccagggcgc cgtcgcgcac
     4441 accgcggaag aggtgtacgc gcgctgcacc cccgtagagg cggccgcggt acgggcgctg
     4501 ctgctgcggc tggtgaaccc cggtgacggg gccgaggaca cccggcggcc cgtcctgcgc
     4561 gacgagctgg gggatgccga caccaccgcg cgggtgctcg aacagctggt gcgggcacgc
     4621 ctgttgacgg tcgacggcga caccgtcgac ctcgcgcacg aggccctgat cagtgcctgg
     4681 ccccggctgc gcggctgggt ggacgaggac cgcgaacggc tgcggctgca tcgcaggctc
     4741 accgaggcgg cgcgcacctg gcagcagttg gaccgggacg ccggagccct ctaccggggg
     4801 gtgcgactga cggcggcgcg cgaggaattc ggctccaggc tgggcgagtt gagccgactg
     4861 gagcgggact tcctggccgc gagcgtgacg gcgtacgagg cgggtcgtcg taccgccgcc
     4921 cgcacggccc gccgtctgcg gagtctgacc gtgtccctcg ccgtgctgct ctgtctcgcc
     4981 gtcgtcgcgg gtgcgaccgc ctggcggcag agcggggtca gcgcacggca gcgggacgag
     5041 gcgcgggccc ggcgggtcgc cgccttcgcg gacacgctcc ggccgacgga tccgcgcacg
     5101 gcgatgcgtc tcgcgctcgc ggcctggcgc accgcggacc tgcccgagac ccgcgaggcg
     5161 gtccggacgg ccgccgccca gagcgaccag gccgccttca ccgagcccgc acagctcggc
     5221 gcccccgacg cgccgcactg gctcggcgcg gacggccgga tcctgacaac ggtcgtacgg
     5281 gacaaggtcg ttcagtggga cgtacgccgt cagcggcacc tgcgcgaggt cgcgctgccc
     5341 ggtctttcgg aggggatcgt cgacgtcagc gccgacgccc gctggatcgc gtaccgcggc
     5401 cgggacggcg cgacggtcag gaacctgacg aacggggaga gccaccgcgt cgccccggga
     5461 tcctggaccg acaccggcgg ggcgttcggg ccgagcggac gcaccttcgt cgtacggcgc
     5521 gagggacggg gggccggaga cgaaggggcc acggtcgagg tgtgggacgt acgacgggag
     5581 cgggtcctct tccgatatcc agggggcgac cgggacggtc cgctgccggt tctgagcccg
     5641 aacgaccgct ttctcgcctg gtgcacccac gacggtgaac gactgcgcgt ctgggacgtc
     5701 gtcgagcggc gccgggtcgc gaccgagccg cccgcgcgga cgcagcggct cctgtgccgc
     5761 tcggacgagc cggtcttcac ccccgacaac cgcgcgctgg ccgcgggaac cgctgacggc
     5821 gtcgtcacct gggacttcca cgccgaccgt ggacgtcccc tgctgccgat gcccggcgag
     5881 gacgtcaact cggtggagtt cgaccctacc ggcgcctacg tcctcacctg gggttcggcc
     5941 ggcctcgccc tgtggcgtac ggacagtccg gccccgacgg acggcggacc gcgccgaccg
     6001 ctcatcacgt tccccgtcga gacacccgcc gtcaccgaca tccggctcga cccgcgcgag
     6061 ggcgtgttgc gctaccgcga aggttcccgg gcgggagtcg tgcgcaccct ctcgctgcac
     6121 gggctcatcg gcacggggtg gcggaacagg gcgcgaaccg acgccgcgtt cgacgcctac
     6181 gggcagccgg ccgaacccgc cgtgcggccc gcggtgcgtg ccgtcgcggc ggacggcacg
     6241 gtgcacaccg ccgtcagcac ccgcgacggg atcctcgtca cccgtcaggg cgcgcacccc
     6301 gtctcccacg tcgtcggaag acggagcgag ggacccgccg cgatcgaccc ggccgggcgt
     6361 acggtcgtga ccgccgaagg agtcctgatc gacgtcgcga cgggcggtcg cagacaggga
     6421 ctccagggcg aggatctcct gccgaccgcg gtcttcagcc cggacggacg ctacttggcc
     6481 gccgccgaca cccaagggcg cctcactctg tgggacgcgg gcgggcagca ccggatcgcc
     6541 gtcctggcag ccgccgactc caccgtcgag cggcccgccc tggccttctc ggccgacggc
     6601 tcgctgctgg ccgcgagccg ggccgacggc tcggtccgcg tgtgggagac ggcgtccccg
     6661 cgactggagg gcgcgaccct gccgaccggc gacgggccgg tcctcgcgat cggattcgcc
     6721 ccgggcgcca aggagttgta cgtcgcgaca ccccatctgc cgctgcgctc agagcagttg
     6781 atgccggaac gtgcggcggg cgaggtgtgc gcccgggcgg ggggcggggc gacccgggcc
     6841 gagtggcgca gatatctgcc cgacgtgccc taccggcgga cgtgttgagg gaggtcggcg
     6901 gccccggcct tgacttcgag ggcgcttcaa gtgatgtact cccgctcgtt gtcgtacaca
     6961 tacgggggta tccatgaccg actcacctgt cgcactcatc accggtggtg gaagcggtat
     7021 cggtgccgcg gtcgcgcggc gactgctcga cgccggccac cgggtcacgg tcaccggccg
     7081 cggcgaggat cggctgcgcg ccttcgccga ggaactcgga cgtccccagg gcttgttgac
     7141 ggtcgtcggg aacgcggccg agtacgacca ggtgcgcgcc gcggtcgagc tgacgctcaa
     7201 ggagttcggc cgcctcgaca ctgtggtcgc caacgcggga ttcgccacgc acgacaccgt
     7261 cgccggcggt gacccggccg gctggtccga gatggtgctg accaatgtgc tcggtcccgc
     7321 gctgctgatc agggcttcca tcgacgccct gaaggagacg cggggccgga tcgtgctggt
     7381 cggaagtgtg gcgggccacg tccacacccc cggcaacatc tacggggcca ccaagtgggc
     7441 cgtgaccggg ctcgccgaga acgcccgccg tgaggtgacc gagttcggtg tcggcgtgac
     7501 cctgatctcg ccgggccggg tggagacccc gttctgggac agctacggga gtctgccacc
     7561 cggtcatctg ctgacggcgg accagctcgc cgagtcgatc gtctgggcga tcggacagcc
     7621 ttcgggcgtc gatgtgaaca ccgtggtggt acgtccgatc ggccagccca actgacgtcg
     7681 gacccgcggg cgcctgggtt gtcgcgtcaa cctcggtcct tgcggaagcc tcagttgttc
     7741 tgcaggaacc gcttcgccaa cgagtccccg agcgacaccg ccgcactgtg actctcgatc
     7801 ggcgacactt gggagttctt gaacaggatg taggtcacgc cggagtcggc cccgcccgtg
     7861 gcggggtcgg ggtcgatgcc gagggccttc gccgtggcgt acgacgcctc gccgatgatc
     7921 ttcgtgggcc cggtgtcgcc gaccaccgcg tactcgacct tgttgttgta gatcacggcg
     7981 acgacaccgc cgcccttgat gccgtagctc gtgtacttcc agatgctgct ggtgctgggc
     8041 acgacgacat acggcagtga ctcggcgcgc agcggcttcc cgtcggactg gtggaacgcc
     8101 gtgtcgtcct ggaaccaggg gtcggcgttg ccgttgcact tgccggtgac ctgaccgtcg
     8161 cagtcgatgt ccatgtcggc cttccagaac accgcgccgt tcttgccgca cacggggatg
     8221 gtggccgagg tctcgtcgtc ggtcttgtac ttgccattcg aaatctgcga acaggacgtc
     8281 accttggcga gcaggtcggc cgcgctgacc gaaccctcct gggcggaacg gggggtgacg
     8341 gagcccgacg cgctggccgg gagtgccgcg gtggcgagga gcgcggcacc ggcgacggcc
     8401 gcgagggtca gtgttcgaga gcgcactgtg ggggaccctt ctgttaggaa agtttcctta
     8461 ccgggttgcg ctacaaggtg gccctcttgc atgaccgcgt caagccctcc ggcggagttg
     8521 gtccggtcca ggggttgaaa tcggcgtggg ggcgtgtcga tgcgtgtcga cgcgggtggg
     8581 ggaagtcgat gtgtgtgggg agagagacgc cgccggcccg gacacgcggt gcgcgtccgg
     8641 gccggggcag gtcagccgat gagggccggg ctcagcccat gtcgaacgtc gccgggtcgg
     8701 gacccaggcg acggtcctcg ttcagcgcgc tgatcgccgc gatgtcctcg gtgtccagcg
     8761 agaagtcgaa gacgtcgatg ttctccttga tccgggacgg ggtcacggac ttggggatca
     8821 cgacgttgcc cagctggatg tgccagcgca gcacgatctg ggccggagtg cggttgtgct
     8881 tctgggcgat ggcgacgatc gccgggacct ccagcaggcc cttgcccgag ccgagcgggg
     8941 accaggcctc ggtggcgatg ccctgctgcg cgtggtactc gcgggtggcg tgctgctgga
     9001 ggtgcgggtg cagctcgatc tggttgacgg ccgggatgac ggacgtcgcc tcgatcagct
     9061 gctccaggta ctccgggtag aagttggaga caccgatggc cttgatccgg ccgtccgtgt
     9121 agagcttctc gaaggccttg tacgtgtcga tgtacttgcc ccgggacggc agtggccagt
     9181 ggatcagata caggtcgagg tagtccaggc cgagcttctc cagggacgtg tcgaacgcgc
     9241 ggagcgtcga gtcgtacccc tggtcgctgt tccagagctt ggtggtgacg aagagttcct
     9301 cgcgggggat gccggaggtg gcgatggcct tgcccgtgcc ctcctcgttg ccgtagatcg
     9361 ccgcggtgtc gatgctgcgg tatccggact ccagcgccgt ggcgacggcc tgctccgcct
     9421 cgtcgtccgg gacctgccag acaccgaagc ccagctgcgg catctcgacg ccgttgttca
     9481 ggatgatcgg ggggaccttg ctcacgagct ctcgatcctt aagtcgtcgg gtggtactcc
     9541 catggtcaac gatcaccggc cgtcatgcat tcctgaccgg cggattagct gtggattcct
     9601 ggtgagggtc ggagattggc cggaaatgga tccgacctta tcggtccgga ccattgaccg
     9661 agttccgtca tccgaccact ctgtagggcg tcaccgaacg ggttcatgaa cccggtgcac
     9721 gcatgtgaac accagcacct gtctgggccc cacacccccc acccatcagg aaagcaggta
     9781 cgcgcacatg aacaagagcg ccctcgaagg ccgccgcgcg gagcaggtca tccgggaaac
     9841 atcggaggaa agtgtctggg agacccccgg gtatctggtc gtcgagaccg ccctggaggt
     9901 cacggcctac gccctcggtg accgcctggg cccggttacc gaacgggcaa ccgccgggcc
     9961 acacctggca cgtacggcct agccccacgg ttgtcgaacc atgaccgcga caccggtgcg
    10021 cgacgacggt gccgcggccc cttggggaac cgccgagttc accgagcggc tgcgcgccat
    10081 cgccgaggac cgctaccacg accgtcatcc cttcaacgtc cgtatgcacc agggcgagtt
    10141 gaccccggcc gagctgcgcc gctggatcat caaccgcttc cactaccaac gccacatccc
    10201 cgtcaaggac gccctgatcc tggccaagtt cgacgatccc gcactgcgac gggtgtgggt
    10261 ccgcaggatc caggaccacg acggcacggc cgtcggacgg ggcggcatcg aacgctggct
    10321 gcggctgggc gaggccgccg gcctcgaacg gccggcgctg tgggacaccg cccgggtgct
    10381 gcccggcgtc cggctcgcgg tcgagggcta cgtcaatttc tgccgcctgc gccccgtgct
    10441 cgacgcggtc gccgcctccc tcacggagct gtccgcaccg gggctgatgc gcacgcggat
    10501 cgccgcgttc gagcggtact acccctggat cgaggcagcg gggctggcgt atttccgtac
    10561 ccgcatcggg cagggcggcc gtgacagcga ggaggcgctc gccctggtcc agggctgggc
    10621 gcgcacccgt gagcagcagg aacgggccgt ggcggcgctg acattcaagt gcgaggtgct
    10681 gtgggcgctc ctggacgcgg tggaccgggc gagcgactcc ggtccgacgg gcacgtcgga
    10741 ccgggtgtcg gggggtaccc cgcggggcga cccagccgcc gcaccggaca ccctgacgcg
    10801 cgcgtcgggc cgcggccgtc ggggtgggtc ggggagaggt tcggatcaac tgccgaatgc
    10861 cttgggcggg gtggcggggg atgcgttgcc cctcgcggct gaggatgcgc cgggggatgt
    10921 ctcgggcctc gcgtccgggc gtgtgccggg agatgtcctg cccttcgtgc ccgagggtgc
    10981 gccgggggat gtctcgggcc tcgggtctga gcgcgtaccg ggggatgtct tgtccttggt
    11041 gtctgagggt gtgcccggag gtgcttcacc ccgtgtgtcc gagcatgtgc cgggggatgt
    11101 ctcgggcctc gggtctgagc gcgtaccggg ggatgtcttg tccttggtgt ctgagggtgt
    11161 gcccggaggt gcctcacccc gtgtgtccga gcatctgccg ggagatgtct cgcccctcgt
    11221 gtccgagtcg gcgtcagggg atgtctcgac cggaggcgcc tcgccgggtc tgtcggattc
    11281 ggtggcgact ccgcgtgggc gcgagcccgc gcagggatgt ccccgcgccg cgcgggacgc
    11341 ggtcggtggc gacgtggctt ccggggcttc gggcgcggcg gcgcaggcgc ggacctcggg
    11401 tgggtcgatg ccgacgaaga tcccgggccg ccaccccggc gcacccgcgc agacgggcac
    11461 cccggtggtt cccggccccg cagggggccc gccatgacgt ggcgccccgt cctcgcccac
    11521 actgtgatgc tccgtcatga tcccgtccgc gacaccgact tgctgctcat gcccgaacgc
    11581 gtcgtcgtcc tgcgcggcca cgccgggagc gtcgtccggc tctgtgacgg caggcgcgag
    11641 gtgcccgaga tcgtcgccgc gctcgccgaa cggttccccg gcgcgccggt cgccgacgaa
    11701 gtaccccgat tcctctcggc gttgcacgag gagggctggc tgcgatgacc tcgaccgtcg
    11761 atcccccttg ggccctgctg gccgaactca cccacggctg cccgctgcgc tgcgcgtatt
    11821 gctccaaccc cgtcgaactg atcagtcggt caagagagct gaccgccgaa cagtgggccg
    11881 acgtctttca tcaagccgct gacatgggcg ttgtccaaac ccacctgtcc ggcggcgaac
    11941 ccctcctcag gcgcgatctc gcccggatcg tcgccgccgc cgacaccgcg ggcctctaca
    12001 cccagctcgt caccagcggt gtggccctgc acgagcgacg gctcgcggag ctgctggacg
    12061 cgggactgcg cagtgtccag ctctccgtac agcacaccga tgcccaggcc gccgaacgca
    12121 tcgcgggagc ccgcgcgttc accgccaagg agcgcgccgc acggttggtg cgggcgacag
    12181 ggctgccact cggtctgaac gtcgtgctgc accgggccaa catcgatgcc gtcgacgacc
    12241 tgatcacgct cgccctcacc tggggcgccg accgtataga gctcgcccac acgcagtact
    12301 acggctgggc cgcccgcaac cgcgccgccc tgctgccgac ccgggaccag gtcgaacagg
    12361 ctcgcgtcac cgtgcgccgc cgacgcggac aactcgccgg ttccctggag ttggtctggg
    12421 tcgccccgga cctgctcgac gccaccgcga aaccctgcat gggcggctgg ggcgccgtct
    12481 ccctcaccgt ggccccggac ggcaccgcgc tcccgtgccc ctccgccgcg acactccccg
    12541 cactcgacgc gccgaacgtg cgcgcacacc ggctcgactg gatctggcgc gagtcgaagg
    12601 ccttcaacgc ctaccggggc gaggcgtgga tgccggaccc ctgtcgcggc tgcgccctgc
    12661 gcacgaccga cttcggcggc tgccgctgcc aggcgtacgc gctcaccggc gacgcctccc
    12721 gcaccgaccc ggcctgccgc cacgcacccg accaccacct cgtccgcgcg ctcgtcgacg
    12781 aggccccgct caggaactcc gcctacgcct accgagaggg aggaacatga gacgacgact
    12841 gcgggcagcg ctgatggcgg gcgtgctcac caccgccggc ctgaccacgg tggccgccac
    12901 cgcgcccccg acacctttac cccgagggcc tgtggggagg cccgccgccg cccaggactg
    12961 gtccgtcgcc ctgatcgact cgaccatggc ccgctacacc ccgagcacga tcggcggctg
    13021 gtcgtacccg gtcgggctgt acctctacgg ccagtacctc acgtaccagc gcacgcacga
    13081 cgcccgctat ctcacctaca tcaagagcta tgtcgaccgc ttcgtgtcga gcgacggttc
    13141 gatcggccag agcttcaaca gtctcgacag catgcaggcg ggccggctcc tgacgatcct
    13201 gcaccacgag acgggccagg accgctaccg caaggcggcc ctgaagatcc ggaaccgtct
    13261 caacacctat ccgcgcacct ccgacggagg cttctggcac gccgacacca gcagccgggc
    13321 ccaccagctc tggtcggacg gcgtctacat ggtgaacccg ttcctcgtcg agtacggcaa
    13381 ggagttcggg gacgcgacct acgcgaacga cgaggccgcc aagcagctct acgtctacgg
    13441 caaccacctc caggtggcga gcggcctgtt gaagcacgcc tacgacgagt cgaagacggc
    13501 gagctgggcc gacccggcga ccggcctcgc cccggagcac tggtgccggg cggtcggctg
    13561 gtacgcgatg gcgatcgtca acgtgctcga cgcgatcccg gtcaaccacc ccagacggcc
    13621 ccaactcgtg ggcatcttca ggaggttggc cgcagggctg gagaagtacc aggacccggc
    13681 caccggccgc tggttccagg tgatcgacaa gggtgcccgc ggcgacaact ggaccgagac
    13741 gtcctgctcc agcatgttca cctacgccct ctcgcgcggc gcccagcagg gctacctcga
    13801 cccgcactac gcgtccgtgg cgcaacgcgg ttaccagggc gtcctcgcca ggatgtcggt
    13861 cggctccgac ggccgcacca acctcaccga catctccatc ggcaccaatg tcggcgacta
    13921 cgcgtactac atcgcccgcg accgtgccac gaacgacttc cacggcctcg gcgcctttct
    13981 gatcatgaac gaacagctca cagcccaccc actcaggacg aggtgagtca gccatgagca
    14041 ccaccagaag gaccctgttc ggcgcggcgc tcggcggcgc cgccggagcc gcggtcggca
    14101 tcccggcgac ggtcaccgcc gcccacgccg cctcctggca gctgaagtgg tcgccgtcgg
    14161 cgagcggcga caagctcggc gccttcgaga cgatcgagga cgaccgcgcc gactcgcacc
    14221 ccgcgggccg gccgcacatc ttcgccaccg gcgacaactg gcgcttcaac atgcacaccg
    14281 tcgaccgcga cacctccacc gaccgtcagc gccaggaggt caccgggctg cgtacgagcg
    14341 ccggcagcta tctcaagtgg accgccgggc agacctggcg gctcacgtac tcgatgtaca
    14401 tcccgagctc gctgaaggcg accacgacct tcacgcacat catgcagatg aagcagccgg
    14461 gcaccggcac ctcgccgatc gtcgtgcagt cactgcgccg ggtgaacggc gtgcagacca
    14521 tcgaactgaa gctcgccatc gacgacatcc tcatcggccg cacggacctg gatccgctgc
    14581 acgacaagtg gacggacgtc gatttccaga tcaaggtcgg tgacggcacg tcgggctcgg
    14641 tccgctggat cctcaagagc ggctcgacca cgatcatcga caagtccagg acgggcgtcg
    14701 acaccttcct cgccgaccgg gttcgcccca agtggggcat ctaccggtcc ctcggcgaca
    14761 cctccgggtc cctgcaggac tgctacctgc tgctgaccaa cctgcgcggc taccaactgg
    14821 tatgaggagc cgttccatga aaccccccat gagaaaacgg agttgggcgg cgagcgtctt
    14881 cttcgccttc gccgtcgtac tcggcctgac ccaccccgag gccctcgcgg ccccccgaac
    14941 cgccacccca cccacgtcca ccacggcgcc cacgtccacc accgcacccc acgccgccgt
    15001 cttcgacgtc cacgactacg gagccaaggg cgacggctcc accaacgaca cccccgccat
    15061 caacaaggcc atcaccgccg ccaacgcggc gggcggcggc accgtccgct tccccgccgg
    15121 ccagtacaag tccaagaaca ccatccacat gaagagcgag gtcactcttc aagtggacaa
    15181 gggagcgacg atccagggct ccagcgcgga cacctacgac ccgcccgagg ccaaccccaa
    15241 cgacgcctac caggactacg ggcacagcca cttccacaac gcgatgatct acggcgaccg
    15301 gctgacacac atcggcttcg tcggtgaggg cgtgatcgac ggcctcggca acctcatcac
    15361 cggcaacccc aagtccggcg aggccgacaa gatcctctcg ctgacccgct gtgacggcct
    15421 gcgcctcggc gacggcctca ccctgcggcg cggcggccac ttcgcggccc tcatcaacgg
    15481 ctgtacgaac gtcacctcgg accacctgac catcgacacc gcgagcgacc gcgacggctg
    15541 gaacatcatc agcacgacca acgtcacggt cacgaacgcc aacatcaagg ccaacgacga
    15601 cgccctcgtc ttcaagagcg actacgcgct cggcgccaag ctccccaacg gccatgtccg
    15661 ggtgagtgat tcgtatctgt cggcggtgtg ctgcaacgcc ctgatgttcg ggtccgagac
    15721 ctgcggagac ttctccgact accagttcgc caagatccgc atcgagggct ccaacaagtc
    15781 agggctcggc atggtctcca tggacggcgc gaagatctcc gacgtccact accgcgacat
    15841 caccatgacc ggcgtccact cgccgatcat gcagaagatc ggtacccgga agcgctgcgg
    15901 caacagtccc ggcgtcggct cgatcagcga cgtcacgtac gacaacatca cggcgaccgg
    15961 ggtgagtccg tccttcagcc cgacgctgtg gggcgagagc ggccaccgga tcaacggggt
    16021 caccttcacc aacgtcgaca tcaccgtccc cggcggcaac ggcaccatgt ccaccgccgt
    16081 gccgagcaac gacccgggcg actacaaccc gaaggccatc ggcacgcggc ccgcctacgg
    16141 ctggtacgtc cacaacgccg acaacatcac cttcacggac agctcggtga agtacgcggc
    16201 cgacgacgga cgtccggccg tcatcgcgaa cgccgcgaac gggatcagat tcacccggtt
    16261 cacggcccag cgggggagca actcacccca tgacatgggc ttccagaacg tcaccggcta
    16321 ctgcctgacg gacagtcaca acacctcggg cggcgcgttg agggtttccg ccggcggttc
    16381 cagtgagaac tgcgctacgc cggccaagag cacgacgatg gcgagcacgg ccgtgcagcg
    16441 gccgcacaca ggtgggaaac cgctcgacct cgaaaacccc cgtcaggcct tcctgcgcgg
    16501 ctccgtcggc ggactcttcc tgcactgggg cgaacgcacc gcccccgccc acaccagttg
    16561 caccgcctgg gagaacgacg tcaccaacgg tggctggact ccggactact gggtgaacga
    16621 ggcccagaaa ctgcacaccc agtacctcgt cctcgccacc ttccacagcc gcctcggtta
    16681 cgcccgcccc tggccctcga agatccccgg cagctgctcc accaagcggg acttcctcgg
    16741 cgaactcatc accgccgcca aggccaaggg cctcaaggtc atcctctaca tgaccgacga
    16801 cccccagtgg cacaacgagg gcggccacga gtggctcgac tcggccgcgt actccgccta
    16861 caagggcacg gacgtcgacc tcaccacccg tgacggcttc ggccgcttca gctacgacaa
    16921 cttcttcgag gtcatggacc gctatccgga cctcggcggc ttctggatcg acaacgacaa
    16981 cgcgtactgg gagagccacg acctctacgc gcagatccag cagaagcgtc cgaactacac
    17041 gctcagcaac aacaacgaag acacgccgat catggacatg atcagcaatg agcagaagac
    17101 gggcatgacc ccgtcctacg actaccccca ggccgtctac acggcccagc cccgcctcac
    17161 cgaagccgac ttcaagctgc cgtcgagcgg agcgtggtgg tacgacggct ccaacccctc
    17221 cgtcgacaag atgctcaccc tcggtcggct gatcaccaac gcgggttcct ccgtgaaggc
    17281 cctgatggcc gagaccgcgc aggtcaacgg caagttcccg acgaaccagg aggccttcaa
    17341 caacttcgcc aactcctatc tcggccccat ctggcagtcc ctgcacggca ccgagggcgg
    17401 cggctacatg tacggcggcc tcaagcccgg cttctggaac gacggagccc acggtgtcac
    17461 cacggtcagc aagaccgacc ccgacctgca gtacatccac gtactgaccc cgcccagcac
    17521 cagcaccagc accctgcgca tccgcgacaa cggctaccgc atcgcctccg tcaccaacct
    17581 ccgtacagga gcggctgttt catggtccca gtcgggcggc gtgctcaccc tgaccggcct
    17641 ggcgaactgg gacccctacg acaccgtctt caaggtcacc acggccggcc gccagggcat
    17701 cgcgtccggc gtcacgatgt ccgcgagcgc ctcggcgagc ggtcacggcg cggcggccgc
    17761 gggcgacggc gactacctca cctactggga cagcaacaag acgctgcccg tcaacctcac
    17821 cttcgacctc ggcagcgcga ggaaggtcca gtacatcggc ctcaaccagc gcgaggactc
    17881 cgtcgcctac gcgcgctccg acaccgagca gtccgcacgt atcaaggact acaaggtgtt
    17941 tctcagcaac gacgggtcca cctggggcag cgcggtcaag accggtcagc tcgccagtcg
    18001 gcggggcatc cagggaatcg acctgaccgc cgccaacgcc cgatacctac gcctcgaagt
    18061 ggacaccacc tgggccgcgt ccaccgacac cacccgctac aagcggctgc ggatcgacga
    18121 ggcctggatc ggcacgtcgt acgccacccc ggcggccacc gtcaacacgt actcggacaa
    18181 cggccaggcc ctgcgccccg ccatgggctg gagcagctgg agcttcgtgc gccgctggcc
    18241 gaccgaggcg aagatcaagg cgcaggccga cgcgctcgtc gcgagcgggc tcaaggacca
    18301 cggcttcgtg tacatcaacc tcgacgactt ctggcagaag tgcgacgcga acggattcgt
    18361 cgtcgactcc tacggacgct ggaccgtcga caccgccaaa ttccccgccg ggatcaaggc
    18421 gctggccgac tacatccact ccaaggggct caagttcggc ttctacgtga cgccgggcat
    18481 cgccaagaac gccgtcacca ggaacacacc gatcgagggg acctcatacc acgcggccga
    18541 catcgcggac acctcgaaga ccgagaagaa ctacaactgc aagaacatgt actacatcga
    18601 ttacgggaag ccgggcgccc aggagttcgt gaactcgtgg gccaagcagt tcgcctcctg
    18661 gggagtcgac tacctgaaga tcgacggggt gggcagcgcc gacatccccg acgtccaggc
    18721 ctgggacaag gcgctgcgcg ccaccggccg gcccatcacc ttcgccctct ccaacaacct
    18781 gccgatcgcg ggcgcctcca cctggaagtc actggcgaac agctggcgca cccagggcga
    18841 cgtcgagtgc tactgcggct cgggcgcgaa cggcagcggc tatccgctga ccgactggtc
    18901 gcacgtctcc gcccgcttca cctcggcggc caactggcag cagtacgcgg gcccgggggg
    18961 ctggaacgac ctggactcgc tggagatcgg caacggcgac caggcgggcc tcaccgccga
    19021 ccagcgccgc tcgcacttca ccctgtgggc gatggcgggc gcgcccctgc tcctcggcac
    19081 ggacctgacg aacctcgact ccgtcgacaa accgatgctc acgaacgacc ggctcatcgg
    19141 tgtcgaccag gacggcgtcg ccgcgaaacg gatcgtgaac agcggcgtca agcaggtctg
    19201 gagcaagaag gagagcgacg gccagtacgt cgtcgccctc ttcaacaccg gcacgtccgg
    19261 caacaccacg gtcggtgtga actggtcgca ggtcggcttc accggctccg gtgacgtcac
    19321 ggacctgtgg tcgggctccc acaagggcac gatcgccgac tcgtacagcg cgaccctgcg
    19381 ccccggggag acgcgcctga tccgggtgaa accggtgagc gccgccctga agaccgccgc
    19441 ggcctcaccc ggcatggcgg tggcacccta cgagtacctc ggctggggca gcccgcagaa
    19501 cccgacctcg gtcatgtcgg ccaccggggt gaagtggttc acgctcgcgt tcgtcctctc
    19561 cgacggctcc tgcaacccga agtgggacgg ctcgcgcccg ctgaccggtg gcaacgacca
    19621 gtcgaagatc aacgcgatcc gcgcggccgg cggtgacgtc gtcgtctccg tcggcggctg
    19681 gagcggcgcc aaactcggcg agaagtgctc cagcgcctcg gcgctcgcgg gcgcctacca
    19741 gaaggtcgtc aacgcctacg gcctcaaggt catcgacatc gacatcgaga acaccgagtg
    19801 gagcaacgcc accgtcagac aacgggtgat cgacgcgctg aagatcgtga aggccggcca
    19861 ccccgggctc aagacgatca tcaccttcgg cacgacgacc agcggcccgg actccaccgg
    19921 cgtcgacatg atcaagcgcg gcgccgcctc gggcctcgcg aacgacatct ggtgcatcat
    19981 gccgttcgac ttcggcggcg gcaccacgaa catgggcacg ctcaccaccc aggccatgga
    20041 gggcctcaag gcacgggtca agtcggctta tggatacagc gacgcgacgg cgtacgcgca
    20101 catcggcctg tcgtccatga acggcaagac cgacgactcc ggtgaactgg tccgcgtcgc
    20161 cgacttcaag accatgctcg cctacgccca gcagcaccac atcgggcgcc tcacctactg
    20221 gtccgtgaac cgcgaccggg cctgcggctc cggctccgac ggtgactcct gcagcggcgt
    20281 gtcgcagcag ccgtacgact acctcaaggt cttcgcccag tacacgggct gaggggacga
    20341 acccatgaaa ctcaacagaa cgctgccctg gtgcctctcg ctcgtcctgg ccgtgccgct
    20401 cgtcgcactg accggcacgg cggcgcaggc ggccaccgac taccaggccg aggacgccac
    20461 gatctcgcag ggcgccgtcg ccaccaacca caccggctac acgggcaccg gcttcgtcga
    20521 ctacaccaac atcaccggct cctacgtgga gttcacggtg agcgcggcca cggccggcac
    20581 ctcctcgctg gccctgcgct acgccaacgg cacgaccgtc gaccgcccga tggacctctc
    20641 cgtcaacggt acggtcgtcg cctccggtgt ctccttcccg gccaccaccg actggaacac
    20701 ctgggcgacg aagagtgtga acgtcccgct cgacgcgggt tccaacaaga tccgcgcgac
    20761 cgccaccacg gcgaacggcg gccccaacct cgaccgcgtc agcgtcggta ccgccgccga
    20821 cacccaggca ccctcgcggc cgggccagcc gagctgctcg gccatcggcg aggacggcct
    20881 caccctttcc tggggtgcct ccacggacaa cgtcggcgtg gccgcgtacg acctctacga
    20941 gcacggcaac aagctcggcg aggcggccgg tgacgcgacc tccaaggtgc tcaccggcct
    21001 gagtccgaac accacctaca acctcaccgt catcgcccgc gacgccgccg gcaacgcctc
    21061 ccaggccagc ccggtcgtcg actgcacgac tcggcccagc tccgacacca ccccgccagg
    21121 caaacccggc accctcacct cctcgaacgt cacggccacc agcgccgacc tgagctgggg
    21181 cgcctcgacc gacgacaagg cggtcgtcgg ctacgacgta cgcagcgaca cgacggtcta
    21241 caagagcgtc accggtacgt cgaccacgct caccgggctc gcctgcaaca gcccgtacac
    21301 gctgaacgtg gtggcgcgcg acgcggccgg caacgtgtcg ccgcagagca acacggtcac
    21361 cttcacgacc aaggcctgtg ccaccgacgg cggggtcccc tcgtccatcg ggaccgtctc
    21421 cagcggctgg acgatcccct ggggcacgta ctggatgccc gacgggcaga cggcgctggt
    21481 caccgagcgg gacgacttcc gggtctggaa ggtcaccaag gacggcacga ggacccaggt
    21541 cggcaccgtg ccgaacgccg tcaccacgaa cggcgagggc ggactgctgg gcgtggccgt
    21601 cgacccgaag tgggccacca accactacgt gtacttcatg cacacggcct ccgagggcaa
    21661 ccgcgtcgtc cgcatgacct acgacggcag ctccctcacc gactacacga tcctcctcca
    21721 gggcatcaag aagaaccgct accacaacgg cggacgcctc gccttcggcc ccgacggcta
    21781 tctgtacgtc tccaccggcg aggcccagac acccgacctg gcccaggaca agacgtcgtt
    21841 gaacggcaag atcctgcgga tgacgacgga tggcaaggcc gcccccggca acccgttcgg
    21901 caactacgtc tacagctacg ggcaccgcaa cccgcagggc ctcgccttcg accgcaacgg
    21961 ccgcctgtgg gaggcggagt tcggcaacag ctccaaggac gaactcaatc tcatcaaacc
    22021 gggtgccaac tacggctggc cgacctgtga gggcagctgc agcgtctccg ggatgaccaa
    22081 cccgaaggcg acctggaacg tctccgaggc gtcacccagc ggcatcgcga tcgtccgcaa
    22141 cgtcgtctac atggcgtccc tgcgcggcga acggctgtgg cgcatcccca tcaccggcga
    22201 cacggagaac gtcggcacgc cgacggcgta ctacgtcggc acctacggcc gcctgcgtac
    22261 ggtcaccaag gtgcccggcg ccgaccagct ctggctctcc accaccaact gcgacaacaa
    22321 cggaggagcg gcggacggct cggacaagat cttcaaggtg agcatcaact agtcgaggtg
    22381 agcatcaact ggccggacgg aggcgtcgca gcgggctcag gcccggtaca acgcctccac
    22441 ctccgtcgcg tacgcgttct cgatcgcctt ccgcttcaac ttaagcgacg gcgtcagcag
    22501 cccgtgctcc tcggtgaact ggttggccag tatccggaac gtacggatcg actcggcctg
    22561 cgagaccagg gtgttcgcgg cgaccaccgc ccgccgcacc tcggtctcca ggtccgggtc
    22621 gcgcaccagg tcggacgggg acagccgcgt cttgccccgc atctgcagcc agtgttcgac
    22681 ggcctcggag tcgagggtga cgagcgccgc gatgtacggc cggtcgttgc cgaccacgat
    22741 gcactgcgcg accagcggat ggtcacgcac gcgctcctcc aggacgcccg gcgagacgct
    22801 cttgccgccg gaggtcacca ggatctcctt
//
