LOCUS       NZ_CP041604            22569 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. S1A1-7 chromosome.
ACCESSION   NZ_CP041604
VERSION     NZ_CP041604.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S1A1-7
  ORGANISM  Streptomyces sp. S1A1-7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 11713216)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 58.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007113565.2-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 04:07:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,902
            CDSs (total)                      :: 10,801
            Genes (coding)                    :: 10,337
            CDSs (with protein)               :: 10,337
            Genes (RNA)                       :: 101
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 80
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 464
            CDSs (without protein)            :: 464
            Pseudo Genes (ambiguous residues) :: 0 of 464
            Pseudo Genes (frameshifted)       :: 185 of 464
            Pseudo Genes (incomplete)         :: 374 of 464
            Pseudo Genes (internal stop)      :: 46 of 464
            Pseudo Genes (multiple problems)  :: 127 of 464
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:07:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5498848
            Orig. end                         :: 5521417
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041604.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041604.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22569
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="18"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22569
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22569
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12569](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12569
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    9..26
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    316..334
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.2"
                     /tool="antismash"
     gene            537..992
                     /locus_tag="FNV64_RS26050"
                     /old_locus_tag="FNV64_26435"
     CDS             537..992
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485793.1"
                     /locus_tag="FNV64_RS26050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26435"
                     /product="DUF485 domain-containing protein"
                     /protein_id="WP_143655199.1"
                     /transl_table=11
                     /translation="MPDPFPYPEYQPRRSGAPYRPAPHFASSDVIYAWQEHQEFDSGAT
                     SPHTGLGHHSDLRVLRRAYRTQRRVATFTALGYFTLFLVLSAFAPSLMTGTVSGGLSTG
                     LLLGLLQVPVTCLAVGLYEHAARRRVDPIADRIRKHAELDVKRGVAR"
     gene            1019..2593
                     /locus_tag="FNV64_RS26055"
                     /old_locus_tag="FNV64_26440"
     CDS             1019..2593
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064625.1"
                     /locus_tag="FNV64_RS26055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26440"
                     /product="cation acetate symporter"
                     /protein_id="WP_240361301.1"
                     /transl_table=11
                     /translation="MSLVAFTAVATIILLLCVMTGPDGDDLDEFYTGYGSLSPMRNGLA
                     IAGDYISAATVLSTGGVIALDGYDGVVLALSIALSLMLLMFLLAEPLRNAGRFTMGDVL
                     ARRMPGRKVRIAACGATIAALLPMMLIQLAGTGDLLAFILGFSSDSLKTGCIVGIGALM
                     ITYAVIGGMKGTALIQVLKIVMLFGSGAVVAALILRQFDWDLGKLFSAAAAHSGVGPAF
                     LHSGLQFAGGPSPRLDMISSELTVILGGACLPHVTMRMYTATSARQVRRSMSWAVSCVA
                     LFMLICTVVSIGATALIGRTTIAGADPTGRTAYLLGSRAALGTSVSTSETFLFTMVTTA
                     LFLTLLASVASMILACANTLAHDLLARRDTTPRREMTIARVSALAVGAPTILLATLVQH
                     HNLQPLALLSASIGASALAPALVYSLFWRRYTRTGLLWTLIGGTLATLVLMTGTNLVSG
                     SPFSAFPHSDFNWFPFTTTGLVSIPLGFAFGWTGTKISGRQKAEEQRQQYEAVEAWILA
                     GAARRGS"
     gene            complement(2875..3672)
                     /locus_tag="FNV64_RS26060"
                     /old_locus_tag="FNV64_26445"
     CDS             complement(2875..3672)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV64_RS26060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV64_26445"
                     /product="hypothetical protein"
                     /protein_id="WP_205522264.1"
                     /transl_table=11
                     /translation="MNWLTSLPAVVLVVGWLALALLVAAAARVGVRVLVPVEERDRVPQ
                     IATPLMPTLGAAFAIFAALTLASEAGYLRAAEGLVSDEAAAASRLAWAATSPRVHSEPI
                     HAALLDYLQTTRAREWEAAAAASGDDPATAHAIARLERSVRAEAARPEVGTPTGTELVV
                     SMDGVTSSRRARIAAASRDVPALYVVTLVVSGLALIVNSGALVFRSSLRTSLLIVGVAS
                     VVGLSLALLFALSAPWSGPFIVSGQPLDAIIEDLKSGFFAGGS"
     misc_feature    complement(3610..3612)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3927..3940
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 23.16"
                     /tool="antismash"
     gene            3967..4431
                     /locus_tag="FNV64_RS26065"
                     /old_locus_tag="FNV64_26450"
     CDS             3967..4431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950289.1"
                     /locus_tag="FNV64_RS26065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26450"
                     /product="hypothetical protein"
                     /protein_id="WP_143601955.1"
                     /transl_table=11
                     /translation="METIIASAIAVLGTLLGSGITLAFQQRTTDRSHQFARREKLRQER
                     LDAYSIYAGALINYRRCLVHLWFCEHEQPPPEDPDSVRIRAYDLRSSAQEALFRVQMLT
                     DDATLGQTAEAVLADITALTKTETRSQLDQRRVQTRDDISRLVRAAKQHL"
     gene            complement(4799..5176)
                     /locus_tag="FNV64_RS26070"
                     /old_locus_tag="FNV64_26455"
     CDS             complement(4799..5176)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893118.1"
                     /locus_tag="FNV64_RS26070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26455"
                     /product="DUF5958 family protein"
                     /protein_id="WP_240361302.1"
                     /transl_table=11
                     /translation="MILNELAQGLRPVADGVEWFEGLSDDDRRKALHTLALFCGQARAG
                     EDDVAESIARSGIRPTHTPAVMLTKWRFGMDRLPASELTKSFRLLVALFGIADTRRRTL
                     HCVGGCGHEWHNLSDQPQDPT"
     tRNA            5429..5570
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FNV64_RS26075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-OTHER"
     gene            5429..5570
                     /locus_tag="FNV64_RS26075"
     gene            complement(5868..6560)
                     /locus_tag="FNV64_RS26080"
                     /old_locus_tag="FNV64_26460"
     CDS             complement(5868..6560)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="FNV64_RS26080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26460"
                     /product="response regulator transcription factor"
                     /protein_id="WP_054228351.1"
                     /transl_table=11
                     /translation="MRINLFILSEDPVSLAGLEAIVEQDDSVNLIGTAVDESHGLRCLE
                     NNPLRPDVVIIAEPPSKRAICRNVAWIVSLYRQEKSRPQIVVVSQNDYDDVIVSALRLG
                     VNGYLARIASPEELFQALHIVARGGAAFSPTIAARFSRFFATIQRLPEPPEFSQLTSRE
                     AEILELLADGMNNRQIARRLFLAEKTVRNYVSRIFTKLEVHDRAAAVLRARDAGFGDQA
                     DAVLPQHA"
     misc_feature    complement(6546..6561)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    6556..6569
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(6595..6608)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
     gene            6711..7844
                     /locus_tag="FNV64_RS26085"
                     /old_locus_tag="FNV64_26465"
     CDS             6711..7844
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958865.1"
                     /locus_tag="FNV64_RS26085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26465"
                     /product="sensor histidine kinase"
                     /protein_id="WP_143655200.1"
                     /transl_table=11
                     /translation="MGDVSRRRLILLDGAAALGFALLPQLTLVRPDSGGAPGGLAVSLL
                     SLATALPLAVRRLWPVPVFAIVLTASCVALAAGLGPAVFLSAAYALYLVATTRRRQLGR
                     SAVIVGGASTAGAALLTVTGGQHYTGGTLAVQLLFGLLVLGATWAAGTAVRERRESLRR
                     TIVQATEQAKVEERMRIARDIHDVVTHSVGLIAIKAGVANHVIATHPEEAGEALTVIED
                     ISRRALRDMRATLKVLRREDDAQQQDLQPVPGLSDLPSLVRTAEAAGVSVELRSDCVEE
                     PPDGVALTAFRIVQEALTNVVKHAAPTRCLVSVTAQDGVLTIGVTDDGPGPGHRPTVPG
                     GAMGLVGMRERAVAHGGTLTAGPRPGAGFRILATLPY"
     gene            7991..8938
                     /locus_tag="FNV64_RS26090"
                     /old_locus_tag="FNV64_26470"
     CDS             7991..8938
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173620.1"
                     /locus_tag="FNV64_RS26090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26470"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_143655201.1"
                     /transl_table=11
                     /translation="MIDVQNLTKRYGPATVVDGLTFTVRPGAVTGFLGPNGAGKSTTLR
                     MMLGLTRPDTGTARIDGHAYGDLAHPLRRIGALLETSAPHRGLTARDHLLWLAQSNRIA
                     RGRVAEVLEAVGLADAARRRTGTFSLGMGQRLGLAAALLGDPPVLVLDEPVNGLDTEGI
                     RWLRDLLRSMAAEGRTVLISSHLMTEMALVADHLVVISRGRLLADTGMSDFIERHGRSY
                     VRVRTAEPDQLGRELEGRGATVSRVPGGGLDVVGMAAADVSRIAAAGGFPLDELATHAG
                     SLEETFLDVIGEEGTRAGADGARALGEEGRNTHV"
     gene            8931..9683
                     /locus_tag="FNV64_RS26095"
                     /old_locus_tag="FNV64_26475"
     CDS             8931..9683
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="FNV64_RS26095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26475"
                     /product="ABC transporter permease"
                     /protein_id="WP_060900510.1"
                     /transl_table=11
                     /translation="MSETLAAVRAETTKLRGIRGTRISLLLFAAVSVLIAALDGWSAKN
                     ALESDNPSLRSDFTPEQAGLDGILYGQLALIVFGVLVVTSEYTSGMIRVSLLAVPRRGR
                     LYAAKTVVTALAAVAVSVPVTVLGYLVTQAALGSHGSSLGASGVPRALAGAVVYLTLMC
                     LFAAGIAAIARNAVVPLAVLLPMVLAGTHILSLIGATKEMARYFPDQAGNELLTVRSPH
                     TAFGFTVLLAWTVAALGWGWVRQRRWDS"
     gene            9799..9927
                     /locus_tag="FNV64_RS26100"
                     /old_locus_tag="FNV64_26480"
     CDS             9799..9927
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_103079660.1"
                     /locus_tag="FNV64_RS26100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26480"
                     /product="aborycin family tricyclic lasso peptide"
                     /protein_id="WP_103079660.1"
                     /transl_table=11
                     /translation="MSAIYEPPMLQEVGDFEELTKCLGVGSCNDFAGCGYAIVCFW"
     gene            10001..11842
                     /locus_tag="FNV64_RS26105"
                     /old_locus_tag="FNV64_26485"
     CDS             10001..11842
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_067372303.1"
                     /locus_tag="FNV64_RS26105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26485"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_143655202.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.5e-37, bitscore:
                     129.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFVVLPDCPASAAAAGRLRATRRVDHASGRPWIVGDWPEAEAVV
                     VQAGPRRMVVLGHTRLDETAAAAALGRLRSLHDVDSIASRLPGAVHLAVSLDGRTRVQG
                     SAVGVRQIFTAVVDGVTVAASGVEPLLRLTGAGLDETVLAARLLAPGGPPWPLAQRPVR
                     RGVEALTTGHWLELDTDGRARQTRWWELPEPSLTLAEGAAAVRSALDDAITSRVAAGGT
                     LSADLSGGLDSTSLCFLAHAAGADLVTYHVTPIDSANADTMWAHRAAECLPAARHHTLS
                     ADRAENLFDVGYTTDLVGAAPEGPSTWASGLAHIQDLAKRATAEGATLHLTGFGGDELF
                     GRMPACAWSLARATPVDGLRLVNRYRLANRWPWRATVRSLLDRSTFTQNLGRVAARIDA
                     PPPPVDEPDFGWVFAPRMPTWATPDAVAAVRALLTDAATEGPGPLDADRARHQALASLV
                     FEGTTVRQVNTALGDTGITWDAPFLDDRVVEAALATRIDQRLLGGRFKPLLTSAARGLV
                     PADILGRRDKGEFSAEAFRGLARNRARILELCEDSQLARLGLIDPAAFRSAVLNPGPMS
                     HHLQPIDTTVACESWLRTHPETYPMPPARNTPTGELR"
     aSDomain        11839..12015
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FNV64_RS26110_Lasso_Fused_RRE.1"
                     /evalue="9.30E-11"
                     /identifier="RREFam003.1"
                     /label="FNV64_RS26110"
                     /locus_tag="FNV64_RS26110"
                     /protein_end="59"
                     /protein_start="0"
                     /score="32.7"
                     /tool="antismash"
                     /translation="MKLTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDG
                     TAPDAAAAGLCAAA"
     gene            11839..12102
                     /locus_tag="FNV64_RS26110"
                     /old_locus_tag="FNV64_26490"
     CDS             11839..12102
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123202.1"
                     /locus_tag="FNV64_RS26110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26490"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_143655203.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 3.5e-08,
                     bitscore: 32.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.7e-23,
                     bitscore: 80.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.9e-11, bitscore: 41.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDG
                     TAPDAAAAGLCAAAPVSDAQARQDVQALIDALSAAKLVEVAS"
     aSDomain        11845..12093
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FNV64_RS26110_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="9.80E-26"
                     /identifier="RREFam002.1"
                     /label="FNV64_RS26110"
                     /locus_tag="FNV64_RS26110"
                     /protein_end="85"
                     /protein_start="2"
                     /score="80.6"
                     /tool="antismash"
                     /translation="LTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDGTA
                     PDAAAAGLCAAAPVSDAQARQDVQALIDALSAAKLVEV"
     gene            12099..12569
                     /locus_tag="FNV64_RS26115"
                     /old_locus_tag="FNV64_26495"
     CDS             12099..12569
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123203.1"
                     /locus_tag="FNV64_RS26115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26495"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_054228345.1"
                     /sec_met_domain="PF13471 (E-value: 4.7e-24, bitscore: 83.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPAVAEQAPRLPWYRQLAPRCAAGAARLLVRLPPARLHRVLGV
                     VSKGSRPAGYAEVARARRSVVSVSTRCAGLGCLQRSVATVLLCRAHGRWADWCTGFRTE
                     PFGAHAWVEAEGRPVDEPGELSVFRTVLAVRRPDGRRSTSDRPLRPSRGSRS"
     gene            12566..13531
                     /locus_tag="FNV64_RS26120"
                     /old_locus_tag="FNV64_26500"
     CDS             12566..13531
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469534.1"
                     /locus_tag="FNV64_RS26120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26500"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_143655204.1"
                     /transl_table=11
                     /translation="MTAIRAEGLYAYYGTAPAVNGLDLTVPTGSVYGFLGPNGAGKTTT
                     INMLTTLLRPTAGRAEVAGFDVAARPAEVRRRIGIVFQESTLDLDLTAAENLRFQADLC
                     GLSRRASRDAIGSMLDLMDLSERRRVPVRQFSTGLRRRLEIARGLLAEPSVLFLDEPTT
                     GLDAQTRAAVWEHLERLRRERGITVFVTTHQLDEAEHCDRIAIIDRGKVVTEGTPADLK
                     SVIGTDLVVLRTDDDQRAAAAIGDRFGLPAEPTPDGLLLRVERAAALVPRLCTELGVTV
                     REVAIAPPTLDDVFLHHTGLAIRESPTGPRTLGNLGEGLR"
     gene            13528..14397
                     /locus_tag="FNV64_RS26125"
                     /old_locus_tag="FNV64_26505"
     CDS             13528..14397
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="FNV64_RS26125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26505"
                     /product="ABC transporter permease"
                     /protein_id="WP_143605450.1"
                     /transl_table=11
                     /translation="MSRTDTAPAALGDVSTAPSPTDRSRNAARPVLLLWRREMTRLRHN
                     PVRLAMGLVTPLLFLVVLGTGLDAASSSLGKAQLNDYRAYLFPGTLVMSVQAPAIAVGI
                     SLVWDRRLGVLRQMLVAPFPRASIVFGLALGGATTGAVYGLMVLSVGGIASIRYTPMLL
                     VVLLELLLVSLMFTALGLLAAVTIRQVDTFQVVVNLSLMPLMFFSGAMFPPNGLPGWLD
                     TVVKLNPLTYGVDAVRRTLPGPSVLTSEQTRLMLGDWHPPVAAELGFLAALTAVALGLA
                     GYRFSRTS"
     gene            14418..14939
                     /locus_tag="FNV64_RS26130"
                     /old_locus_tag="FNV64_26510"
     CDS             14418..14939
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="FNV64_RS26130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26510"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_205522265.1"
                     /transl_table=11
                     /translation="MDASTTDVTTTAAVRATTGHWAGAARFVARLLLAAVLAYAGLVKI
                     GDLTEAGRTVALYRIVPADSAQLVGGVLPFVEVALALLLAAGLATRAAAAGAAVLLVAY
                     AAAIASVWARGMSIDCGCFGGGGTLSGGAARGYALDLARDLLLLGAAALLIRNPRTRYA
                     LDGWVLDPKE"
     gene            14945..15676
                     /locus_tag="FNV64_RS26135"
                     /old_locus_tag="FNV64_26515"
     CDS             14945..15676
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013488.4"
                     /locus_tag="FNV64_RS26135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26515"
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_143601965.1"
                     /transl_table=11
                     /translation="MTSTQTTDATVREMVHRRQRRRRTVVVSLVAALVVVAAALVGAGL
                     VRANNTAPGKAPSRVPAGLAADKSGVAASTGAVRVDVYLDYLCPECRRTERALTTALDS
                     LRAHGGVSVVYHPVAFLDDRSAPAGYSTQAASAAACAADAGRFERYSTVLFSKQPAEQG
                     PGLSEAQLIAAGRDAGITAASFARCVEDAPYLPWVRYVSDLAASRKVALTPTVMVEGRR
                     VDVTGSDPGGALTRAVTAARR"
     gene            15673..16995
                     /gene="mslH"
                     /locus_tag="FNV64_RS26140"
                     /old_locus_tag="FNV64_26520"
     CDS             15673..16995
                     /codon_start=1
                     /gene="mslH"
                     /inference="COORDINATES: protein motif:HMM:NF038314.1"
                     /locus_tag="FNV64_RS26140"
                     /note="Involved in the biosynthesis of MS-271 and related
                     lasso peptides; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26520"
                     /product="lasso peptide C-terminal Trp epimerase"
                     /protein_id="WP_143655205.1"
                     /transl_table=11
                     /translation="MTRLTVALSGDCMATRGAVISSDPAAGRLHELLHGADFAVTNLEV
                     VPSDGRGHPVHNAAGGGCLIADSGVLDEITAAGFTVLGCANNHAMDLGTEGVLGTVDLL
                     RSRRIPFAGIGADLTTARRPVYVDRPGGSLALLACTATFLPGQEAADPSPELPGRPGLS
                     PLRHSATLRVTAPQMDVLRTIDAETGLRARRAEARTLLGVDPALLGPDRLSLFGTRFLT
                     ADEPGFTTECDPRDLDEISRWVGEARLRADLVVVSVHSHEPGPTPETPGEFLRVFAHRM
                     IDEGADVVVGHGPHFLRGVELYRNRPIFYSLGNIVSQIELTDRVSAEDYAKVTTDRPPT
                     PGRYYDRLSGHGTRLFAPHRRYWQSLVPVLTFDDGTLVTARLHPVDLGFALPVHRRGRP
                     RLADQAEAKEILTEVARLSESYGTTVRAGVDGTAELLLDVA"
     misc_feature    17032..17048
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.09"
                     /tool="antismash"
     gene            17085..17759
                     /locus_tag="FNV64_RS26145"
                     /old_locus_tag="FNV64_26525"
     CDS             17085..17759
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123207.1"
                     /locus_tag="FNV64_RS26145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV64_26525"
                     /product="response regulator transcription factor"
                     /protein_id="WP_054228340.1"
                     /transl_table=11
                     /translation="MAESVRVLIADDQALLRGSFRVLVDSTPGMEVVGEAGDGAMAVRL
                     ARELAPDVVLMDLRMPVLDGIAATREICSDETLTGVRVLALTMFDMDEYVYPALQAGAS
                     GFMLKDASPSDLVDGIRVIATGEGVLAPTVTRRVIANFSRRGETPRPAPRLVGLTKREH
                     EVLVQIANGLSNAEISERLVISMPTVKTHVGSLLAKLHARDRAQLVIIAYESGLAERGM
                     PT"
     misc_feature    complement(17086..17100)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    18139..18151
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.61"
                     /tool="antismash"
     misc_feature    18150..18165
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.58"
                     /tool="antismash"
     misc_feature    18281..18296
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            18284..18661
                     /locus_tag="FNV64_RS56265"
                     /old_locus_tag="FNV64_26530"
     CDS             18284..18661
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV64_RS56265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV64_26530"
                     /product="hypothetical protein"
                     /protein_id="WP_143601968.1"
                     /transl_table=11
                     /translation="MSVSRKAVRLIATCVATGALVGAAAMPALAAGGGHDRDNGRGYSH
                     SYRSDHDHGGHFGDRDRDRDRDRGWGWGLDRGHDRGWDRGHDRDRDRDRGWDRGRGWDR
                     GERHGWYSDRHRDQDRYLGHH"
     gene            19530..>19904
                     /locus_tag="FNV64_RS56270"
                     /pseudo=""
     CDS             19530..>19904
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013508.4"
                     /locus_tag="FNV64_RS56270"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVNGQGEWFGNDHAFDNIRILDATPQLDKAFSPATVDKGGTSTLT
                     MTVTNTSELAAKNDFSFADNLPAGVKVASTANASTTCGNGTVSATAGGTSVALNGGDLA
                     AGEKSCTVTVNVTADKAGTYV"
     misc_feature    19543..19561
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.89"
                     /tool="antismash"
     gene            <19977..>20129
                     /locus_tag="FNV64_RS55355"
                     /pseudo=""
     CDS             19977..>20129
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896029.1"
                     /locus_tag="FNV64_RS55355"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="chaplin"
                     /pseudo=""
                     /transl_table=11
                     /translation="MATAVGTATGSGGLLSGNVVQVPVDMPVNACGNSVNVIGLLNPAA
                     GNVCVN"
     misc_feature    complement(20137..20157)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.86"
                     /tool="antismash"
     misc_feature    20353..20368
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.43"
                     /tool="antismash"
     gene            20934..21155
                     /locus_tag="FNV64_RS26160"
     CDS             20934..21155
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV64_RS26160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164662801.1"
                     /transl_table=11
                     /translation="MGRVTVTACVLRRGPCHADRHEQTSTSRVSVGLGTYAGPLYGRLS
                     ARGLIPVCDLVLIPVPVLVPVSGGGCGP"
     misc_feature    complement(20941..20953)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
ORIGIN
        1 aggacgaagg tcgcgtagag cggatctccg cgagaggcgg cgaggaagtc gagcgtctcg
       61 tccagcgtcc agggcttcaa ctccctgttg tccgtgcggg gcggctcgac cagcttggcg
      121 acgacgtggc cctggaccca gctgttcacc accgcgttca cgcgactcca gtgactgccg
      181 gatcccggct gaccagcaac aacgccccgc cccaacgagc cgttccacga ccggagcagt
      241 ggaacccggc gcccacccga cgcgacggcc gggcctcgac catgcccgcc acccgcctga
      301 gcagccgaaa cggcccactg gatgaaccga cgggccgtca cgaaacatcg aggccagtgg
      361 cccgtgatcc cccggcgccg aacagaagta gttgatacag ccatcgatct gctgcatacc
      421 aactgttcag tttggccaga gcctggcgca ggtccatacc tgctgggtag cgtgcgccca
      481 ccccccgctt cccttcggtc ccgtatgggt ccatgagtcg catgaggaga aacgggatgc
      541 cagatccgtt cccttatccc gaataccagc cgcgccggtc aggagcgccg taccgacccg
      601 cgcctcattt cgcctcttcc gatgtcatct acgcgtggca ggagcatcag gagttcgaca
      661 gtggggcgac gtcgccccac acggggctcg gtcaccacag cgacctacgt gtgttgcgcc
      721 gcgcctaccg cacccagcgg cgcgtggcga cgttcacggc actcggatac ttcacgctct
      781 ttcttgtgct gtccgcgttc gcaccgtcgt tgatgacggg cactgtctcc ggcggcctgt
      841 ccacggggct gcttctcggg ctgctccagg tacccgtcac ctgtctggcg gtcgggctgt
      901 acgagcacgc cgcgcgtcgc agggtcgacc cgattgcgga ccgcattcgc aagcacgccg
      961 agctggacgt gaagcgggga gtggctcggt gagcggtttc agcagttcca cgcaagcgat
     1021 gtctttggtg gcattcacgg cggtcgctac gatcatcctg ctgctgtgcg tgatgacagg
     1081 acctgacggt gacgacctcg acgagttcta caccgggtac gggtcgctgt ccccgatgcg
     1141 caacggcctt gccatcgctg gggattacat ttctgcggcg acggtcctgt ccacaggcgg
     1201 ggtgatcgcg ctcgacgggt acgacggcgt cgtcctggca ctgagcatcg ccctctccct
     1261 catgctgctg atgttcctgc tggccgaacc gttgcgcaac gccggccggt tcaccatggg
     1321 cgacgtgctt gcgcggcgga tgcccggccg caaggtgcgc atcgccgcgt gtggggcgac
     1381 gatcgcggcc ctgctgccga tgatgctcat ccagctcgcc ggcaccggtg atctgctggc
     1441 gttcatcctt ggcttttcca gtgactcgct gaagaccgga tgcatcgtcg ggatcggcgc
     1501 actgatgatc acttacgcgg tgatcggcgg tatgaagggc acagccctca tccaggtctt
     1561 gaagatcgtg atgctgttcg gctccggcgc ggtcgtggcc gcgctgattc tgcggcagtt
     1621 cgactgggac ctgggcaagc tgttctccgc cgcggcagcg cacagcggcg tggggccggc
     1681 cttcctgcac tccggtctcc agttcgccgg tggccccagc ccccggctcg acatgatcag
     1741 ctcggagctc accgtcatcc tcggcggcgc ctgcctgccg cacgtcacca tgcgcatgta
     1801 caccgcgacc agtgcccgtc aggtgcgccg gtcgatgtcc tgggctgtgt cgtgcgtcgc
     1861 actgttcatg ctgatctgca cggtcgtcag catcggggca acggcgctga tcgggcgcac
     1921 gacgatcgcc ggtgccgacc cgacgggcag gaccgcgtat ctgctgggct cacgggccgc
     1981 gctcggaacg agtgtttcga cgtccgaaac gttcctgttc accatggtca caacggcgct
     2041 tttcctcacc ctgctcgcat cggtcgccag catgatcctg gcctgtgcca acaccctcgc
     2101 gcacgacctg ctcgcgcgcc gtgatacgac tccccgccgc gagatgacca tcgcccgggt
     2161 ctccgccctg gcggtgggcg cccccaccat cctgctggcc accctcgtcc agcatcacaa
     2221 tctgcagccg ttggctctgc tgtcggcctc catcggtgca tccgcactcg caccggcact
     2281 ggtctacagc ctcttctggc gccgctacac ccgcacgggt ctgctgtgga ccctgatcgg
     2341 cggcacactc gccaccctcg tcctcatgac cggcaccaac ctcgtctccg gttccccctt
     2401 ctccgccttc ccgcactccg acttcaactg gttcccgttc accaccaccg gccttgtctc
     2461 catacccctg ggcttcgctt tcggctggac agggacaaag atctccgggc ggcaaaaggc
     2521 ggaggaacag cgccagcagt acgaggcggt cgaagcatgg attctggcgg gggcggcgag
     2581 acgaggaagc tgaattgtgc cgaaagcacc gcccaggcgg cctgggtacc ggccaggccg
     2641 gactgctgcg gtaccggctc cagcagtacc cgtgaacccg cggacgtaca gccgaccccg
     2701 tgcggtcgtg ccagacccgt gccagacccg tacgggaaac cacggggaac accggggaac
     2761 cggccgacct cgcaccggga cagctcgaca acaggtcagg tggttgattg attgggcggc
     2821 cgcacgtcac gggccgccgg tgatcagttg tcggctactg atcgcgcccg gcgcctacga
     2881 cccgccggcg aagaagccgg acttcaggtc ctcgatgatg gcgtcgagtg gttgcccact
     2941 gacgatgaac ggtccgctcc agggcgcgct gagtgcgaag agcaacgcca ggctcagccc
     3001 gaccacactc gcaacaccta cgatcagcag cgacgttcgc aggctgctgc ggaagaccag
     3061 tgcgccggag ttcacgatca aggccagtcc gctgaccaca agcgtgacga cgtagagcgc
     3121 gggaacgtcg cgcgaggcgg ccgcgatgcg ggcgcgacgg ctactggtga caccgtccat
     3181 ggagaccacc aactccgtgc ctgtcggggt tcccacctcg ggccgggccg cctcggcgcg
     3241 cacactccgc tccaggcgtg cgatcgcgtg agcggtggcg gggtcgtcac cggacgccgc
     3301 tgctgcagcc tcccactccc tggcacgcgt ggtctgcaag tagtccagaa gtgccgcatg
     3361 gatcggctcc gaatggactc gcggacttgt cgccgcccat gccagacggg aggccgcggc
     3421 cgcctcgtcg ctcaccaacc cctcggctgc gcgcaggtag ccggcctcgc tggccagtgt
     3481 gagtgccgca aagatcgcga aggcagcgcc gagggtcggc atcaggggcg tggcgatctg
     3541 cggcacccga tcccgttcct cgaccggtac gagcacccgg acgccgaccc gcgccgcggc
     3601 cgcgaccagt aaggcaagcg cgagccagcc cactaccagc accaccgccg gcagcgaggt
     3661 caaccagttc accacatcac ctacagcgcg ttcccgcgag cgccctgcgg cggcggcaca
     3721 tcggccccgc gacctggagc tcctcgtcga tcactcttaa tgaacgctcc atgatcacag
     3781 gttgaagacc tttgacgctc gcgacgcccg gcacggcatc tcttttcatt ggccgaacag
     3841 ccgaatacgc ccagtacgag gccgtactga caacgaccgc cacgcccatc tcgccttccg
     3901 tctcattcag cctcgttcag cgctgttcga ccgagatcaa aagccgatac gtgatcagct
     3961 tgggacgtgg agaccatcat cgccagtgcc atagccgtcc tcggaacctt gctcggctcg
     4021 ggaatcacac tggcgtttca gcaacgcacc accgacagaa gccaccagtt cgcccgccgt
     4081 gagaagctcc ggcaagaacg actcgacgcc tactccatct acgccggcgc gctgatcaac
     4141 taccgccgct gcctggtgca cctgtggttc tgcgagcacg aacaaccgcc acccgaagac
     4201 cccgactccg tccggatccg tgcctacgac ctgcgctcaa gcgcacaaga ggccctgttc
     4261 cgggtccaga tgctcacgga cgacgcgacc ctgggtcaga ccgcagaggc cgtcctcgcc
     4321 gacatcaccg cactgaccaa gacggagacc agaagccaac tcgaccagcg ccgagtacag
     4381 acccgtgacg acatcagccg actcgtcaga gcagccaagc agcatctttg aggcaccccc
     4441 ggacgcagcc cttcgtacgg cctgtccagc gcagcctccc aagctgaggg ctcaggcacc
     4501 gtcgctacgg tccggccggc gcggtttgct ctggtcgacc gcaccggcaa cgtggccgaa
     4561 gccagttagg gtgcggcgag atatacgcgg tgcgtcactg cgcaatggcg ggcggcttcc
     4621 accggctgac gccgttcatg taccccatgg ccgggccccg tccccgggcc gtccgaggtc
     4681 gctcgacagt ggccgaggac gaccagcgac ggccatcagg cgcgcgggac catcgcgcct
     4741 gagcagggag atctcaggcc accgagatcc ccgacaaggc ccagggcaag aagtagccct
     4801 aagttggatc ctgcggctga tctgacagat tgtgccactc gtgaccacac ccgccgacgc
     4861 agtgcagcgt ccgcctgcga gtatcggcga tgccgaaaag ggcgacgagc agccgaaatg
     4921 acttcgtgag ttcagaggcc ggaagtcggt ccatcccgaa gcgccatttc gtgagcatca
     4981 ccgcaggcgt gtgcgtgggc cgaatgccag agcgcgcgat actctccgcc acatcgtcct
     5041 cccccgcacg agcctgcccg cagaacagcg ccagcgtgtg caaggccttg cgccggtcat
     5101 cgtccgagag gccctcgaac cactcgacac cgtcagccac gggtctgagc ccttgcgcga
     5161 gttcgttcag gatcacctcg tgtgcgtaca gcacagcctc tcacccccat gcgatcaggc
     5221 cgacggtacg cccgcgggcg cccgagagca gcacagtttt aggtgttccg tgcaggacgg
     5281 tttcgtccac ttctacgacg aggaaggccg aaggggttct cgaccagggc gaaccaggta
     5341 gccatggtcc agcagctcca gcggtacggc agcttcgtac ctcaaaaccc cagcaaccgc
     5401 cctggcccgg cccgataccg tccctggagg cttcgtagcg gccggtatga ccgtcgccga
     5461 cttcccgtcc gggcccgcta gatcacccga agaaaccgcg ggtcaccccc aagacgcccc
     5521 cgtctctccc ccaaagcggg tgtcgcaggt tcaaatcctg tcggggcaca gagaaacacc
     5581 aggtcagagt gctcctcggc gtccatggcc tgagtgagcc tgccgggacc gaagtggaac
     5641 ttcgagggat cgtgggagga gaggcgggac agtccgacgg cgtcgggccg aaggtgtcgg
     5701 cggccggatg gccggggccg tcgatgccga gcgccttggc cgaggtcacg ctgctgatcc
     5761 ggtcgctgcc cggtgctgcc ggttccacgg ggatccggcc gccagtgaag tcgccggcac
     5821 cgcgagcacg ctgaccagag ggccgcgcgc tcgctctcct ggcgttgtca ggcgtgttgg
     5881 ggcagtacgg catcggcctg gtcgccgaaa ccggcgtcgc gtgcgcgcag tacggcggcg
     5941 gcccggtcgt gcacctccag tttggtgaag atgcgggaga cgtagttgcg tacggtcttc
     6001 tccgcgagaa agaggcgccg ggcgatctgg cggttgttca tgccgtcggc gagcagttcc
     6061 agtatctccg cctccctgct ggtcagttgg gagaactcgg gcggctcggg gagtctttgt
     6121 atggtggcga agaacctgct gaagcgagcc gcgatcgtcg ggctgaacgc ggcgcccccg
     6181 cgggccacga tgtgcagcgc ctgaaacagt tcctccgggg acgcgatccg cgcgagatac
     6241 ccgttcacgc cgaggcggag ggcggagacg atcacgtcgt cgtagtcgtt ctgcgacacc
     6301 acgacgatct gtggccgtga cttctcctgg cggtacaggg agacgatcca cgcaacgttc
     6361 ctgcagatgg cgcgttttga cggtggctca gcgatgatca ccacgtccgg ccggagcggg
     6421 ttgttctcca gacatcgaag gccgtgggat tcatcgaccg ccgtgccgat gaggttgacg
     6481 ctgtcgtcct gttcgacgat cgcttcaagt ccggccaggg acaccgggtc ctcactgagg
     6541 atgaagagat tgatccgcat agctttgcac ccccgtggta agcgttgtac gcctgcaaag
     6601 acggtgccag cctaagcaga ctaaacggac ggactacacc gacttgagcg gtcatggtcc
     6661 ggttccggcc gcgttggacg tccggctgat cagacacata ggttcgggac atgggagatg
     6721 tctcgcgccg acgcctgatc ctcctcgacg gggcggcggc cctcgggttc gccctgcttc
     6781 cgcaactgac gctggtacgg cccgacagcg gcggcgcgcc cggtgggctc gccgtatcgc
     6841 tgctctcgct cgccaccgcg ctgccgctcg ccgtacggcg gctgtggccc gtcccggtgt
     6901 tcgcgatcgt cctcaccgcg tcctgcgtgg cgctggccgc cggtctcggc cctgccgtgt
     6961 tcctctccgc ggcctacgcc ctgtacctgg tcgcgacgac acggcgacgg cagctggggc
     7021 ggtcggccgt gatcgtcggc ggggcgagca cggcgggcgc ggccctgctg acggtgaccg
     7081 gcgggcagca ctacacaggc ggcaccctgg cggtgcaact gctgttcggg ctattggtgc
     7141 tgggggcgac gtgggccgcg gggacggccg tacgggagcg acgcgagagc ctgcggcgga
     7201 ccatcgtgca ggcgaccgag caggccaagg tcgaagaacg catgaggatc gcccgggaca
     7261 tccacgacgt cgtcacccac agcgtgggcc tgatcgcgat caaggccggg gtcgccaacc
     7321 acgtcatcgc cacccacccc gaggaggccg gagaggccct caccgtcatc gaggacatca
     7381 gccgcagggc gctgcgcgac atgcgggcca ccctcaaggt gctgcgccga gaagacgacg
     7441 cccagcagca ggacctccag ccggtccccg gactgtcgga cctgccttcc ctggtccgta
     7501 cggccgaggc ggcgggcgtc agcgtcgaac tgcgctccga ttgcgtggag gaaccaccgg
     7561 acggggtcgc gctgaccgcg ttccggatcg tccaggaggc gctgaccaac gtcgtcaaac
     7621 acgctgcccc gacccgctgc ctggtcagcg tcaccgcgca ggacggtgta ctgacgatcg
     7681 gcgtcaccga cgacggcccc ggacccgggc accggccgac cgttcccggc ggcgccatgg
     7741 ggctcgtcgg gatgagggaa cgggccgtcg cgcacggcgg gaccctcacg gcgggccccc
     7801 gccccggcgc gggcttccgg atcctcgcga cactgccgta ctagtgccac gccaaccgcc
     7861 atacgtcccg ccccccgcat atggctgaaa cggtctcata ccccggtatg ggtccggtcc
     7921 gcgaaaccgg cccgcaccgt cccgaccccg gtccgatgtg tggtgcggcc gccgcggcca
     7981 gactcgtcgc gtgattgacg tccagaacct gaccaagcgg tacgggccgg ccaccgtcgt
     8041 ggacggcctg accttcacgg tgcggcccgg agccgtcacc ggcttcctcg gccccaacgg
     8101 cgccgggaag tcgaccaccc tgcggatgat gctgggcctg acccgccccg acaccggaac
     8161 cgcgcggatc gacgggcacg cctacggcga cctggcccac cccctccgcc gcatcggcgc
     8221 cctgctggag acctcggccc cgcaccgcgg cctgaccgcg cgcgaccatc tgctctggct
     8281 cgcccagagc aaccggatcg cccgcggccg ggtcgccgag gtcctggagg cggtcgggct
     8341 cgcggacgcg gcccggcgcc ggaccggcac cttctccctc ggcatgggcc agcggctggg
     8401 cctggccgcc gcgctcctcg gcgacccgcc cgtgctggtg ctcgacgaac cggtcaacgg
     8461 cctggacacc gagggcatcc gctggctgcg cgacctgctg cgctcgatgg ccgccgaggg
     8521 ccgtaccgtc ctcatctcca gccatctgat gaccgagatg gccctggtcg ccgatcacct
     8581 ggtcgtcatc agccggggcc ggctcctcgc ggacaccggg atgtccgact tcatcgagcg
     8641 ccacggacgg tcgtacgtcc gggtccgcac cgccgaaccc gaccagctcg gcagggagtt
     8701 ggaaggtcgc ggcgccacgg tgagccgcgt ccccggcggc ggcctggacg tcgtgggcat
     8761 ggcggccgcg gacgtcagcc ggatcgccgc ggcgggcggc ttcccgctcg acgaactcgc
     8821 cacccacgcc gggtcgttgg aggagacctt cctcgacgtc atcggagaag aaggcacccg
     8881 cgcgggagcc gacggcgcac gcgccctcgg tgaggaaggc aggaacaccc atgtctgaga
     8941 ccctcgcggc cgtccgcgcc gagaccacca agctgcgcgg cattcgcggc acccggatct
     9001 cgctgctgct gttcgccgcg gtcagcgtcc tcatcgccgc actcgacggc tggtccgcga
     9061 agaacgcgct ggagtccgac aacccgagcc tgcgttccga cttcaccccg gaacaggccg
     9121 gtctcgacgg catcctctac ggccagttgg cgctgatcgt gttcggcgtc ctcgtcgtca
     9181 ccagcgagta cacgtccggc atgatccgtg tctccctgct cgccgtcccc cggcgcggac
     9241 ggctctacgc ggcgaagacg gtcgtcaccg ccctggcggc ggtggccgtc tccgtccccg
     9301 tcaccgtcct cggctacctg gtcacgcagg cggccctcgg gtcccacggt tcctcgctcg
     9361 gagcgagcgg tgtcccgcgc gccctggccg gggcggtcgt ctatctgacc ctgatgtgcc
     9421 tgttcgcggc gggtatcgcg gcgatcgccc gcaacgccgt cgtaccgctg gccgttctgc
     9481 tgccgatggt gctcgccggg acgcacatcc tgtccctcat cggggcgacc aaggagatgg
     9541 cccggtactt ccccgaccag gcgggaaacg aactgctcac cgtccggtcc ccgcacacgg
     9601 ccttcggctt cacggtgctg ctcgcctgga ccgtcgccgc cctcggatgg ggctgggtgc
     9661 gccagcgccg gtgggacagc tgacaggacc ggcatgggac aactgcccca tgccggtggg
     9721 acagtccgcc ccgtagcttc cgtgacagat cacaggccga acaaggtcgg cctgaccgat
     9781 ccgaaacggg aggacaccat gtccgcgatc tacgagcccc ccatgctcca ggaagtcggc
     9841 gacttcgagg agctcacgaa gtgcctcggc gtcggaagct gcaacgactt cgccggctgc
     9901 ggctacgcga tcgtctgctt ctggtgatca cgtccggtgc cggtgcgttc acgcgcaccg
     9961 gcaccacccg gggtgacgag gagacgggga acgaggcgac atggaattcg tggttcttcc
    10021 ggactgcccg gccagtgccg ccgcagccgg ccggctgcgg gcgacgcggc gcgtcgatca
    10081 cgcgtcgggg cggccctgga tcgtcggcga ctggcccgag gccgaggccg tcgtcgtcca
    10141 ggcgggccca cggcggatgg tcgtgctggg acacacccgg ctcgacgaga ccgccgcggc
    10201 ggccgcgctc ggccggctgc gctcgctgca cgacgtggac tcgatcgcgt cccggctgcc
    10261 gggagccgtc cacctggcgg tgtcactgga cggcaggacc agggtgcagg gttcggccgt
    10321 cggcgtacga cagatcttca ccgccgtcgt cgacggggtg accgtcgccg cgagcggggt
    10381 ggaacccctg ctgcggctga ccggcgccgg cctcgacgag accgtgctag ccgcccgcct
    10441 gctggcgccg ggcggacccc cctggccgct cgcccagcgc cccgtccgcc ggggcgtcga
    10501 ggcgctcacc accggccact ggctggaact ggacacggac ggccgggccc ggcagacccg
    10561 ctggtgggaa ctcccggagc cgtccctcac gctcgcggag ggcgcagccg ccgtccgttc
    10621 ggcactggac gacgcgatca ccagccgggt cgccgcgggc ggcaccctga gcgccgacct
    10681 gtccggcggt ctggactcca cgtcactgtg cttcctcgcg cacgcggccg gcgccgacct
    10741 ggtcacgtac cacgtgacgc cgatcgacag cgccaacgcg gacacgatgt gggcccaccg
    10801 ggccgcggag tgcctgcctg cggcccggca ccacacgctg tccgccgacc gcgccgagaa
    10861 cctgttcgac gtcggctaca ccaccgacct cgtgggcgcg gccccggagg gtccctcgac
    10921 ctgggcctcc ggactcgccc acatccagga cctcgccaag cgggccacgg cggagggcgc
    10981 cacactgcac ctgaccggct tcggcggtga cgagctgttc ggccggatgc ccgcgtgcgc
    11041 ctggtccctg gcccgggcca caccggtcga cgggctgcgg ctggtcaacc gctaccggct
    11101 ggccaatcgc tggccgtggc gggcgaccgt acgctcgctc cttgaccgct cgacgttcac
    11161 gcagaacctc ggtcgggtcg ccgcccgcat cgacgccccg cccccgcccg tcgacgagcc
    11221 ggacttcggc tgggtgttcg cgccccgcat gccgacctgg gcgacccccg acgccgtggc
    11281 cgcggtccgc gcccttctca ccgacgccgc caccgaggga cccgggccgc tggacgccga
    11341 ccgggcccgg caccaggcgc tcgcctcgct cgtcttcgag gggaccaccg tccgccaggt
    11401 caacaccgcc ctcggggaca ccggcatcac ctgggacgcg cccttcctcg acgaccgggt
    11461 ggtggaggcg gccctggcca cccggatcga ccagcgcctg ctcggcgggc ggttcaagcc
    11521 gctgctcacc tcggccgcac ggggtctcgt ccccgcggac atcctgggcc gccgtgacaa
    11581 gggcgagttc agcgcggagg cgttccgggg cctggcccgc aaccgggccc ggatcctgga
    11641 gctgtgcgag gactcccagc tcgcccggct cggcctcatc gacccggcgg ccttccggtc
    11701 cgcggtgctg aacccggggc cgatgtccca ccatctccag ccgatcgaca ccacggtggc
    11761 gtgcgagagc tggctgcgga cgcatccgga gacgtacccc atgccacccg cccggaacac
    11821 gcctacggga gaactccgat gaagctgacc ctcgcccgcg acgtcaccct caccgtcgtc
    11881 gactccgggg ccgtgctgct cgacgggcgc cgcgggcgct actggcaact gaaccactcc
    11941 ggcgcgggcg tcctgcgcca actgctcgac ggaacggcgc ccgacgcggc cgccgccggc
    12001 ctgtgcgccg cggccccggt cagcgacgcc caggcacggc aggacgtcca ggccctcatc
    12061 gacgcgctca gcgcggccaa gctcgtggag gtggcctcgt gaccaccccc gccgtggccg
    12121 aacaggcccc gcggctgccc tggtaccggc agctcgcccc ccgatgcgcc gcgggggcgg
    12181 cccgtctgct ggtccggttg ccgccggccc gactgcaccg cgtgctgggc gtggtcagca
    12241 aggggtcccg ccccgccgga tacgccgagg tggcgcgggc ccgccggtcc gtcgtctcgg
    12301 tcagcacccg ctgcgcgggc ctcggttgcc tccagcgttc cgtggccacc gtcctgctgt
    12361 gccgggcaca cggcaggtgg gccgactggt gcacgggatt cagaaccgaa ccgttcggcg
    12421 cgcacgcctg ggtggaggcc gaggggcggc cggtggacga gcccggcgaa ctcagcgtgt
    12481 tccgcacggt cctggcggtc cgccgcccgg acgggcgccg gagcacctcc gaccgtcccc
    12541 tccgcccctc ccgagggagc cgctcatgac agcgatccgg gccgagggcc tctacgcgta
    12601 ctacggcacc gcaccggccg tgaacgggct cgacctgacc gtgcccacgg gcagcgtcta
    12661 cggcttcctc ggaccgaacg gcgcgggcaa gaccaccacc atcaacatgc tgaccaccct
    12721 gctccggccc accgcgggcc gtgcggaggt ggccggcttc gacgtcgccg cccggcccgc
    12781 cgaggtccgc cgccgtatcg gcatcgtgtt ccaggagtcg accctcgacc tggacctcac
    12841 cgccgccgag aacctccgct tccaggccga cctgtgcggc ctgtcccggc gcgcgtcccg
    12901 cgacgcgatc ggctcgatgc tcgacctgat ggacctctcc gagcgccgca gggtgcccgt
    12961 acggcagttc tccaccggac tgcgccgccg cctcgagatc gcccgtggtc tgctcgccga
    13021 gcccagcgtg ctgttcctcg acgagccgac gaccggactg gacgcccaga cccgcgccgc
    13081 cgtctgggag cacctggaac ggctgcgccg ggagaggggc atcacggtct tcgtcaccac
    13141 ccatcaactg gacgaggccg agcactgcga ccggatcgcg atcatcgacc ggggcaaggt
    13201 ggtcacggag ggcacacccg cggacctcaa gtccgtcatc gggaccgacc tcgtcgtcct
    13261 gcgcaccgac gacgaccagc gcgccgccgc cgccatcggc gaccggttcg gcctcccggc
    13321 ggagcccact ccggacggtc tgctgctccg ggtcgagcgc gcagcggccc tggtgccccg
    13381 actgtgcacc gaactcggcg tgaccgtacg cgaggtcgcc atcgccccgc ccaccctcga
    13441 cgacgtcttc ctgcaccaca ccggtctcgc catccgggag agcccgaccg gcccgcgcac
    13501 gctcggcaac ctcggggaag gactgcgatg agccggaccg acaccgcacc cgccgcactc
    13561 ggcgacgtca gcaccgcacc atcaccgacc gaccggtccc gcaacgcggc gcgccccgtc
    13621 ctgctgctct ggcggcggga gatgacccgg ctgcggcaca accccgtgcg cctggccatg
    13681 ggactcgtga caccgctgct gttcctcgtc gtcctcggca ccggcctcga cgcggcgtcg
    13741 tccagcctcg gcaaggccca actgaacgac taccgggcct acttgttccc cggcacgctg
    13801 gtcatgtccg tgcaggcgcc ggcgatcgcg gtgggcatct cgctggtgtg ggaccgcagg
    13861 ctgggggtgc tgcgccagat gctcgtggcg ccgttcccgc gcgcgtccat cgtgttcgga
    13921 ctggccctcg gcggcgccac caccggcgcg gtctacggcc tcatggtgct gtccgtcggc
    13981 gggatcgcga gcatccgcta cacgccgatg ctgctggtcg tcctcctcga actcctgctg
    14041 gtctccctca tgttcaccgc gctcgggctg ctcgccgccg tcaccatccg gcaggtcgac
    14101 accttccagg tcgtggtgaa cctgagcctg atgccgctga tgttcttctc cggcgcgatg
    14161 ttcccgccca acggcctgcc cggctggctc gacaccgtcg tcaagctcaa cccgctgacg
    14221 tacggcgtcg acgcggtccg ccggaccctg ccaggaccga gcgtgctcac ctcggagcag
    14281 acccggctga tgctcggcga ctggcatccg cccgtggccg ccgaactggg tttcctggcc
    14341 gccctcaccg cggtcgcgct gggcctcgcc ggctaccggt tctcccgtac gtcatgaggc
    14401 cgggaggaca gagcacggtg gacgcgagca cgacggatgt gaccacgacg gccgccgtcc
    14461 gggccacgac cgggcactgg gcgggcgcgg cgcggttcgt ggcccggctg ctcctggcgg
    14521 cggtcctggc ctacgccggt ctggtgaaga tcggggacct cacggaggcc gggcggacgg
    14581 tcgcgctcta ccgcatcgtg cccgccgact cggcccaact cgtgggcggt gtcctgccgt
    14641 tcgtcgaggt ggcgctcgcg ctgctgctcg cggccgggct ggccaccagg gcggcagcgg
    14701 cgggagcggc cgtactgctg gtcgcctatg cggcggccat cgcctcggtg tgggcacggg
    14761 gcatgtccat cgactgcggc tgtttcggcg gcggaggcac gctcagcggt ggcgccgcac
    14821 gcggctacgc gctcgacctc gcgcgcgatc tgctgctgct cggcgcggcc gccctcctga
    14881 tccggaatcc gcgcacccga tacgcgctgg acggctgggt cctggacccg aaggagtgag
    14941 gggcatgacg agcacacaga caacggacgc cacggtgcgg gagatggtgc accgacggca
    15001 gcggcgacgg cgcacagtgg tggtgtctct ggtggccgcc ctggtggtgg tcgccgccgc
    15061 gctggtgggc gcgggcctgg tccgggcgaa caacacggcg cccggcaagg caccgagccg
    15121 cgtaccggcc ggactcgccg ccgacaagtc gggcgtggcc gcctccaccg gcgccgtacg
    15181 cgtcgacgtg tacctcgact acctctgccc cgaatgccgt cgtaccgaac gggcactgac
    15241 caccgccctg gacagtctga gggcgcacgg cggggtgagc gtcgtctacc acccggtcgc
    15301 cttcctcgac gaccgcagcg cacccgcggg ctactcgaca caggcggcgt ccgcggcggc
    15361 ctgcgcggcg gacgcgggga ggttcgagcg gtactccacg gtcctgttct cgaaacagcc
    15421 cgccgaacag ggcccagggc tcagcgaggc ccagctgatc gcggcgggcc gggacgccgg
    15481 catcaccgcg gcgtccttcg cccgctgcgt cgaggacgcc ccctacctgc cctgggtacg
    15541 gtacgtctcc gatctcgccg cctcccgcaa ggtggcgctg accccgaccg tcatggtgga
    15601 gggccgccgc gtcgacgtca ccggctccga cccgggcggc gcgctgaccc gggcggtcac
    15661 ggcggcccgg cggtgacccg gctgaccgtg gccctgtccg gggactgcat ggcgacacgg
    15721 ggagcggtga tctcctccga cccggccgcc ggacggctcc acgaactcct ccacggcgcc
    15781 gacttcgccg tcaccaacct ggaggtggtg cccagcgacg gacgcggaca cccggtgcac
    15841 aacgcggccg gtggcggctg tctgatcgcg gactccggtg tcctggacga gatcacggcg
    15901 gccgggttca ccgtgctggg ctgcgccaac aaccacgcca tggacctggg cacggagggc
    15961 gtgctcggca ccgtggacct gctgcggtcg aggcggatcc cgttcgccgg gatcggcgcc
    16021 gacctcacca cggcgcgccg gcccgtctac gtcgaccggc cgggcggcag cctggcgctg
    16081 ctcgcctgca ccgcgacgtt cctgcccggc caggaggcgg ccgatccgtc gccggaacta
    16141 cccggacggc cgggcctcag cccgctgcgc cactccgcga ccctgcgggt gacggccccg
    16201 cagatggacg tgctgcggac gatcgacgcc gagacgggcc tgcgcgcccg tcgggccgag
    16261 gcccgcaccc tgctcggggt cgaccccgcc ctcctcggac ccgaccggct cagtctcttc
    16321 ggcacccgct tcctgacggc ggacgaaccg ggcttcacga ccgagtgcga tccgcgcgac
    16381 ctcgacgaga tctcccgctg ggtcggtgag gcccgcctcc gcgcggacct cgtggtggtg
    16441 agcgtgcact cccacgagcc cggcccgacg cccgagacac cgggcgagtt cctacgtgtc
    16501 ttcgcgcacc ggatgatcga cgagggcgcg gacgtcgtgg tcgggcacgg cccgcatttc
    16561 cttcgcggtg tcgagctgta ccggaacagg ccgatcttct acagcctcgg caacatcgtc
    16621 agccagatcg aactgaccga ccgcgtctcc gcggaggact acgccaaggt caccaccgac
    16681 cggccgccca ccccgggccg ctactacgac cggctgagcg gccacggcac ccggttgttc
    16741 gccccgcacc gccgctactg gcagtcgctc gtgccggtcc tcaccttcga cgacggcacc
    16801 ctcgtgacgg cccgcctcca cccggtcgac ctcggcttcg ccctgccggt gcaccgcagg
    16861 ggccgcccac gcctggccga ccaggccgag gccaaggaga tcctcaccga ggtcgcccgg
    16921 ctgtcggagt cgtacggtac gacggtccgg gcgggggtcg acggcacggc ggagctgctt
    16981 ctggacgtgg cgtgaagggc cgtgcgtggc aggcgagttg acgagagagc cttgctaaaa
    17041 tgtcatatgt cacctacgag cggacgagga accggggaac acgcatggcc gagtcggtcc
    17101 gggtactgat cgcggacgac caggcactgc tgcgcgggag cttccgggtc ctcgtcgact
    17161 ccacacccgg catggaggtc gtcggcgagg ccggcgacgg cgccatggcg gtccggctcg
    17221 cccgggaact cgccccggac gtcgtcctga tggacctccg gatgccggtt ctcgacggca
    17281 tcgcggccac ccgggagatc tgctccgacg agacgctgac cggtgtccgg gtgctggccc
    17341 tgaccatgtt cgacatggac gagtacgtct acccggccct ccaggcgggt gccagcggct
    17401 tcatgctgaa ggacgcctcg ccgtccgacc tggtcgacgg catccgggtc atcgccacgg
    17461 gcgagggtgt actggccccc acggtcaccc ggcgcgtcat cgccaacttc tcccggcgcg
    17521 gcgagacgcc ccgccccgct ccacgactcg tcggtctcac caagcgggaa cacgaagtcc
    17581 tcgtccagat cgccaacggc ctgtccaacg cggagatctc cgaacgcctg gtcatcagca
    17641 tgccgaccgt gaagacccac gtcggcagcc tcctggccaa gctgcacgcc cgggaccgcg
    17701 cacagctggt catcatcgcg tacgagagcg gcctggccga gcggggaatg ccgacgtgac
    17761 cgcggcgacc aggactcacg gcgcctcgcc ccgctgggcg gctgcgcggg ggtggccgtc
    17821 gtcgccggtg tcgcaggttc gaaacctgcc ggggcacagc gagaagggca cctacggatc
    17881 gccgtaggtg ccccttttgc atccaggtct gacgaccgga tcgccgcgaa ccgcgacggt
    17941 cccccgaaca gaggcccccg tcgttactga agccattggg ccgttcggag gagtcggggc
    18001 agcgggacag ccaagggtgt cacgggccgt cagctgctta ttttcctgct ctcagcgtga
    18061 ttccacgcca ggacagggcc gacacccagg cccctccacg gcgtcaatgg cccatacaag
    18121 ggagagttac ggatatatct gcactttgta acgcgaatcg tttccttggc ctggtgtcgc
    18181 agtggagggc cacagtgtgg gcctcggcac cgagccggga atgacggatt gcacgcccgg
    18241 ccccgaccag ggtcggtgtg cacgaacgtg aggtgacaga ttcatgtctg tttctcgtaa
    18301 ggcggtccgc ctgatcgcca cctgtgtggc tacgggcgcg ctcgtcggcg cggccgccat
    18361 gccggccctg gccgccggag gcggccacga ccgcgacaac gggaggggtt actcgcacag
    18421 ttacaggagc gaccacgacc acggcggcca cttcggcgac cgggaccggg accgcgaccg
    18481 cgaccggggc tggggctggg gcttggaccg gggccacgac cggggctggg accggggtca
    18541 cgaccgggac cgggaccggg accgcggctg ggaccgaggc cggggctggg accggggcga
    18601 gcgccacggc tggtacagcg accggcaccg ggatcaggac cgctacctcg gccaccacta
    18661 gcccgccttg gcgactgtgc tgcgacgcgg aggcccacac ccactgccac ccgtcgtcat
    18721 gaccggcacg gccgctgtac ccagccggag ggccgaagac cgttccttgc ggtcttcggc
    18781 cctccggcca cgtgtcgcac gacacccaca aggttcacct gatcaaattc accgcgccgg
    18841 tgtcctgggt agcacttgcg ctcgcgagtg ctccgctggc ctctcaagcc caggccctgg
    18901 tcatgccgct gtgcgtgaac gcccggcatg cgcctggcac tccgggcggc ccgcaggccc
    18961 cggtcacggt gttcgccgaa gacttcgaaa acgcgggcga gactccgatc ttcctggaga
    19021 actacgtcgg cgctccaccg ctcgacgaga cgtacacagc cgaccccccg tggctcgacc
    19081 acggacagtg caacggcatc atcctcgatc agaccggcgc tgatcagccc gactgcccgg
    19141 cggtattgaa gaacatggcc aatgcgctgg gacaggtagg cggaacgaat ccgccgacca
    19201 accacgtggt cgcggcctac accaactggg tgccacctgg cgccgaccgg gtggagttcc
    19261 gaacccagcg gccgatcccg atcgcgaagc cgaaccgcta catcaccttc gcagtggatg
    19321 tagccgccgt gaattgcggc caagccgttc ctccgctgct gaagttctat ctgaccggca
    19381 acggggcaga catcccgacc ttcaccaccc ccatcaatcc ctgcgccgac cccaactcca
    19441 agccctatcc cggaggaaac gggttgaggg ccgggacgtt cgccggcaac agagccgtac
    19501 tgttcaacga tagccagttg ggcatcaaga tggtcaatgg gcaaggcgaa tggttcggca
    19561 atgaccatgc gttcgacaac atccggatcc tggatgcgac tccgcaattg gacaaggcgt
    19621 tcagtcctgc caccgtggac aagggtggca cctcgacgct caccatgacg gtgacgaaca
    19681 ccagtgaact ggcggcgaag aacgacttca gcttcgccga caacctgccc gccggagtga
    19741 aggtggcctc gaccgcgaac gcgtcgacga cctgcggcaa cggcacggtg tccgcgacgg
    19801 cggggggcac gtccgtcgct ctgaacggcg gcgacctggc cgccggcgag aagtcctgca
    19861 cggtcacggt gaacgtcaca gccgacaagg cgggaaccta tgtgaaccgc cccgaagcga
    19921 tcaccacggt tggcctgaat ctcccggacc ccgcgacgct gaccgtcaag atgaagggag
    19981 caacagcggt gggcaccgcg acgggctcgg gcggtctgct gtccggcaat gtggtgcagg
    20041 tacccgtaga catgccggtc aacgcctgcg gcaactccgt gaacgtcatc ggactgctca
    20101 acccggcggc aggcaacgtc tgcgtcaacg gctagccgat cgtcgggctg acctaatcag
    20161 ttgacatcaa cgccgcatgt atcgaacagc ccccacggag caatctccga gggggctgtt
    20221 tcatgcgtgc gggaacaatg cgggaccccc tcaagctttg ctcaattccc tggtccggat
    20281 tggagaactc atgcgaacat cgcgtggtcc gccgccatcc gaccaggtgg cgggcatgat
    20341 tcagggggaa tctccatgct tttttcgccg aagtcgccag cgtaccgcca tgaccaccgt
    20401 gcactggcag ccgtcggcgc ggcgcccgtt tcatcgatcc gggccttgtc gtgcgaagcg
    20461 gtgcaacgtc cggcccggct gggacacctc tgtcaagtct gatcgaacct acctgtgttc
    20521 ccaggtggtt ctcaccaccg agaccgctgt aggccgcagg aaatatggcc caactctgtg
    20581 ccgtgggggc cagtttcggc gagcgcgata taggtgacag ggaagttccc aggacggtag
    20641 cgcggctgag ccgccaccgg taccacctcg tggcatcaaa gggaatggcg gccgtagtgc
    20701 tgccccgtgc cgttgtgtgc aactgaccac ctcacccatc acgttaccgc cggctttccg
    20761 cggaaccact cgggacagta agccaattct ggccaccgcg agttggcgga aggtcgattt
    20821 ctcgtgccca gattccctga aacccacagg agtggaacgt tgtcgtatcg aagacacctg
    20881 ccagtcgtcg ccctgctgtg cgcggccgtg ctcggcaccg cagccccgaa cacatgggcc
    20941 gtgtcaccgt caccgcgtgc gtcctccgcc gcggaccctg ccacgccgac cgccacgaac
    21001 aaacctcgac cagtcgcgtc agcgtcggcc tcggcaccta cgcggggccc ctctacggtc
    21061 gtctctccgc ccgcggtctc atccccgtct gcgacctcgt cctcatcccc gtccccgtcc
    21121 tcgtccccgt ctccgggggc ggctgcgggc catgaggctc aggaggctgc caagtactgg
    21181 accgcacagc gcatggccga cgcccgaccg ctggacgccc tacggtcggc accgtccgcc
    21241 cgcaaacacg caatgccggc ggcggggaac gcctctccga acggcaccct gttcggcgga
    21301 acccgcctcg taggaacgtt cttcggctcc agcagcccaa ccggtacgaa ctggtcgtgc
    21361 acgggcagcg tgatcgacac ccaggccaga aacgtgatcc tcaccgcggc gcactgcgga
    21421 ctcggctaca gcaacaacta catcttcgta ccgaaattca tcaagggcgc ggggcccgac
    21481 cagcagccct acggcatctt ccacatccag cacgtcttca tcgacccccg ctacatacct
    21541 gacacgggcc attcgtcgac caagaagccc tggtccgatc tggacaccgc gttcgcgcgc
    21601 gtctcggcga atcagcgcgg ccggcagctc caggacgccg tggggggagg gctgaccttc
    21661 acccagccga ccggctacaa ccacaaggac gtcacggtcg tgggctatcc gggcaaggac
    21721 cacaacgggg ccgggcaagc catcaagtgc accgtaccga cgacgcaatt gccggggttc
    21781 cgtcagatgt cgatgacctg tggcggctac tacggtggcg tctccggcag cccgtggatc
    21841 accgactacc aggacgacgc acgcaccggc catgtcatcg gcaacctcgg tggctacaac
    21901 ggcggcggca acgacgcgga cgtcgactac atcagctatg ccccggcctt cggttccgac
    21961 gccgccaacc ttctcgccga cgccatagcc aaccaggacc ctccgtccaa cctgcccccg
    22021 taccagggca tccaggcgaa gctccctgga ggagcgacgc tgtggcagca cgcgaagctg
    22081 ctggcctcgg gcgactacac gggcaaccgc cgcagcgaca tgatcgtggt ctggtccgac
    22141 ggcgaagtca ccttgtaccc cggtgacggc aagggcgggt tcctgccgga gagacggctt
    22201 caggcgccca actccacctg gacacacgcg gagaccgtca caggcggaga cttcaccggc
    22261 tccgatcttt ccgacctcat ggtgcgctgg tccgacggtg aggtcactct ctacccggac
    22321 gtcagcgctt cgggcctgag cggagaagtc cagatggcgc cctccggctc cctgtggaag
    22381 aacgcaattc agatctcggc cgggcagttc cacaacggga agtacgccac ggacctgatg
    22441 gtgcgctggg tcgacggcga actgaccctc tacacctatg tcggtgccgg caccttcggg
    22501 accgagaacc gcctgctggc tccgaacgac acctggaaga acgccacctt gctgaccagc
    22561 gggaacttc
//
