LOCUS       NZ_CP041610            10216 bp    DNA     linear   CON 14-NOV-2023
DEFINITION  Streptomyces sp. RLB3-17 chromosome, complete genome.
ACCESSION   NZ_CP041610
VERSION     NZ_CP041610.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RLB3-17
  ORGANISM  Streptomyces sp. RLB3-17
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66.0x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/14/2023 04:19:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,027
            CDSs (total)                      :: 10,924
            Genes (coding)                    :: 10,421
            CDSs (with protein)               :: 10,421
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 503
            CDSs (without protein)            :: 503
            Pseudo Genes (ambiguous residues) :: 0 of 503
            Pseudo Genes (frameshifted)       :: 178 of 503
            Pseudo Genes (incomplete)         :: 409 of 503
            Pseudo Genes (internal stop)      :: 52 of 503
            Pseudo Genes (multiple problems)  :: 128 of 503
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10493309
            Orig. end                         :: 10503525
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041610.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041610.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="39"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(561..575)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            complement(1880..4102)
                     /locus_tag="FNV62_RS47270"
                     /old_locus_tag="FNV62_47925"
     CDS             complement(1880..4102)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="FNV62_RS47270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_47925"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_054236566.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.9e-38, bitscore:
                     130.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPDTRSRRRTAPPKRTVPKAKGKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHLPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDTAALAEVKA
                     PAILFWEFNHYVVYDGMGRRFGRRGVHINDPGKGRRFVPMEDFDTSFTGVVLVMEPGPD
                     FHKGGRKPGVLGAMPARLRGTSGTMPAAVLASLLLVAVGAAVPALSRTYIDTYLIGGRT
                     SLLGVLFASMGACVALTVVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTAVGIGVALLNVI
                     AMRVVIRLRATRTAKLRADNARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSALILWIGGLRAVEGHISVGLLVAFQALVTRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFQTDPLYARSGSGESTRRLQGHVELENITFGYSP
                     LDKPLLTGFSLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWEGTIRIDGQRLEDIPR
                     GALAASVSFVDQDVFLFEGTVRDNVALWDPSIPDEAVVAALEDAALYEVVTRRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQTVIDNLRKRGCACV
                     VIAHRLSTVRDSDEIVVLQHGTIVERGRHEALVAAGGPYAELVKER"
     gene            complement(4099..4908)
                     /locus_tag="FNV62_RS47275"
                     /old_locus_tag="FNV62_47930"
     CDS             complement(4099..4908)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="FNV62_RS47275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_47930"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_144316228.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLALSVTVVVMAAASVW
                     AVTGTVASTVSAPAVLTHGEGSYILQSPVAGQVTEVVAQEGERLAANAPVLKVRTTQGG
                     TTVVRTVAAGRVTALAATIGAIISTGANVAAVEKVAHADDPLYATVYVPAESAATIPAN
                     AAVDLTVQSVPTQQYGVLRGHVKAVGRSVQTPQQISSFLGDSQLGEQLSKKGRPVAVLV
                     RLDRSAATKSGLKWSSADGPPFALTSMTLATGSIRLADQRPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="FNV62_RS47280"
                     /old_locus_tag="FNV62_47935"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="FNV62_RS47280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_47935"
                     /product="hypothetical protein"
                     /protein_id="WP_054236564.1"
                     /sec_met_domain="strepbact (E-value: 5.1e-37, bitscore:
                     125.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVATAEISDADLDNVSGGLSLNAVGTVTGLVDGVAPVSGL
                     VNTVVGTVEGVTGLNTAPVTGLVAGL"
     misc_feature    5232..5245
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    complement(5768..5781)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.44"
                     /tool="antismash"
     misc_feature    complement(5769..5782)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.79"
                     /tool="antismash"
     misc_feature    5770..5783
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.15"
                     /tool="antismash"
     misc_feature    5771..5784
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.86"
                     /tool="antismash"
     gene            5886..7295
                     /locus_tag="FNV62_RS47285"
                     /old_locus_tag="FNV62_47940"
     CDS             5886..7295
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988892.1"
                     /locus_tag="FNV62_RS47285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_47940"
                     /product="S1 family peptidase"
                     /protein_id="WP_179858408.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAIAVGGVAALGAAALLLPHANASQTDAKGAAPKT
                     LKSADASNLASLLASQLGDAFGGAYWDASKQQVIVNVVGNNSNVVNTVEKAGAVPRSVN
                     NSLSALKTAAKTLKSDATIPGTAWSIDPKTNQVQVTADSTVTGAKWAKLTSTVDSLGSG
                     VATVKKSAGTFKTFVSGGDAIFAQANGGGVRCSLGFNVTASDGAPAFLTAGHCGVAAKQ
                     WSDSQNGQPIATVDQATFPGAGDFSLVKYDDPATQTVSEVNEGNGKTVQITQAADATVG
                     QQVLRMGSTTGLHDGSVTGLDATVNFQSETVPGGVDTVTGLIQTNVCAEAGDSGGSLFT
                     ADGSAVGLTSGGSGDCTAGGETFFQPVTAALQATGATLGAGGAAGAGGASAAATDPAAT
                     DPAATDPAATDPAATDPAATDPAATDPAATDPAATDPAATDPAAGGQSGTGSGQSSTGM
                     NAGSGLVTSTP"
     gene            complement(7445..9604)
                     /locus_tag="FNV62_RS47290"
                     /old_locus_tag="FNV62_47945"
     CDS             complement(7445..9604)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="FNV62_RS47290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_47945"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_143629652.1"
                     /transl_table=11
                     /translation="MVGVSDWQGSVQAPAGRRTPVGRPLLSLTLASMMEEVHAHSGAVY
                     LLTPGEAVLEMAVMAGMPRSFAAPWERVGLNAPIPVAVAVRERRLVWVGGEEEMARRFP
                     RIAVVLPYPFALAALPVATAGTVYGAVFVTWPGSHPVDLSDRERDHLTASCARLALRLE
                     RAAAERRPVHPEPDLLAPSAAPATGVLGTLEAARMVARLPYGLCALDLNGRVSFANAAT
                     ADMLGVPVSELLGTQLWASVPWLNDPVYEDRYRAALISQHVTSFVALRPPGNWLSFRLY
                     PNTTGLSVRISRARAVAEMGRVESRHGEDDTTPRLVTISQVLSLAGALTQAAGVEDVVQ
                     LVADEIAPAVGSKALVVLGSRSGRLHVLGHRGYADAHIVERWHGVPLSAQTPGTQALKT
                     GVPAFFDSRQQLERLYPDRSATPDGMAAWAYLPLIASGRPVGTCVLGYAEPHTFPAEER
                     AVLTSLCGLIAQALERALLYDAKLQLAHGLQAALLPHSLPTLPSIEAAARYLPATQGME
                     IGGDFYDLVPSHGLAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQPPEEVMRSTNR
                     LLIDLGAELFASCLYLRLDPAREVAVMSRAGHPPPLLLRPDGRVRVLDLAGGPLLGIDA
                     AATYPTTEVPLVPGSVLALYTDGLIESPGVDIEDALADLGRKLAEGGDLSLNALADRLV
                     EQTGAVTQERLDDVALLLLRVRPHD"
     misc_feature    complement(9893..9908)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.66"
                     /tool="antismash"
     misc_feature    9899..9913
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.65"
                     /tool="antismash"
ORIGIN
        1 cagcggcagg tacaccgcgc ccatcaccgt cgtgaggttc ttgatgcggc cgaccttctg
       61 ctggagctca cggctgcgcg cgaactcgcc cgcccaggcg gcgtacgcgt agttctcggc
      121 cgccgcgacc cgcagcttgg gcagaccgcg cagggtctgg aacgcctggt tgttcagctt
      181 gttgctgagc acgaccaggc ggcgctgcca gcgcacctgc cacagtccga gcccgaggaa
      241 cgcggccgcg atgacgacga gcatgccgat cgcggcgagc gccaggggca cgctgtacca
      301 aaggagcagc cccaggttca tcgcgccgac cgtgcccgcc tgcgcgagcg tcggtccgac
      361 gcccgcgagg aggcggcgga tcgcgctgat gcccatggcg gcgctggcca gctcaccggt
      421 cgagcgggac gtgaagaact tcgtgggcag ccggagcagc cggtcccaca cggccggttg
      481 gagcgtcgcc tcgatccgcc cctccatccg cagcatcgtg aggttctgga gcagcatgaa
      541 cgccgccgac acgatgctgg tgaccatgat ggccagacag acctgcacga tcagtccgtg
      601 ctgggccttg ggcacgtact cgccgagcac ctggccggtg gcgatcggca ccagcgcgcc
      661 gatcgcgacg gtgacgagac cgctgatcgc gaggttgcgc aggtcgccgc ccgtgccctg
      721 gaggcagaag cgcagcagcc gcagcgggct cagcttccgc tcgggcagcg gccggtagaa
      781 catcacggcc cgcgccccga actccggcgc gttggccttc tcgaccgggg tctctcgccc
      841 cgaagacggc tgtacggcca cgtatccgcc gcgccgccac agcagcgcga ccggggagcc
      901 cgacacggcg cggtggccca ccagcgggcc gatgttgtcg cgccaccagc gcccgtcgag
      961 gcgtacggca cgggtgcgga cgcgcgaggc gagcgcgatc cgctccaccg ggtcgagccg
     1021 gtcgctctcc gtgccgctgt gcgcggactc ggcgagggtg atcccggacg cgcgggcgac
     1081 cagcttgcag gcggcgtacg tggcgtccgc gtcggccgcc gtcgggcgct tggacgactt
     1141 gccgatcgac gccagcaggg tccggtcggc ctgggcgcgg acggcctcgc ccgccttgat
     1201 gcccgccgcc gtacggtcct cgtggctggc ctccaactgc tcgatccagc ggtcgagcgt
     1261 ggacagcagc cggtactgct ggtcgaccat gccctgccag acaccggagt ccatcagcag
     1321 atcggccgcc gcctcggcgc cgtacaggga gccgtactgg acactcccgg gcggcacctg
     1381 catccagaag acgtcgtcgt cggtcagcgc ggcggcgttc tccgtggcca tcggcgcctg
     1441 gaacagaatg gacaggctgc ggccgacgcc gagggcgagg gcgtactcca gcgggctcga
     1501 cgtcggcggt acgtactggg ggttgccgta gtcgtcgtag gaccaggtct gggtgtccac
     1561 cggctggtac agctcgcgca gcacgatccg gcgcaccaca cagtcccgca acggccgccc
     1621 cacgagggtg tgttgtgggc ccgcgacggg gccgagcagc agggagcccg cttcgaggcg
     1681 gccgaggtgg tgccagtggc cctgctggac ggcatcgacc gcgaacaggt ccatggcacc
     1741 cgccgccacc agccagagga cctgcggtcc ttccagatcg aggcggccga ggccggagca
     1801 gtcgaccggc gttcccatgc cgccgagcgc gccgaggacg aggtctccct cgcgtgcgcc
     1861 ctcgtgaacc gtggtcatct catcgctcct tgaccagctc ggcgtacgga ccgccggccg
     1921 ccaccagggc ttcgtgccgc ccgcgttcca cgatcgtgcc gtgctgcagc acgacgatct
     1981 cgtcgctgtc gcgcacggtg ctgagccggt gcgcgatcac cacacaggcg cagccgcgct
     2041 tgcgcaggtt gtcgatgacc gtctgctcgg tctcggcgtc cagcgcgctg gtcacctcgt
     2101 cgagcaccag gatgctgggc cggcgcacca acgcccgtgc gatctccagg cgttggcgct
     2161 ggccaccgga gaagttgcgg ccgtcctgct cgacccggct gtggatgcca ccggggcggc
     2221 gcgtgacgac ctcgtacagc gccgcgtcct ccaacgccgc gactacggcc tcgtcgggga
     2281 tggacggatc ccacagggcc acgttgtcgc ggaccgtccc ctcgaagagg aacacgtcct
     2341 ggtcgacgaa ggagacggag gcggcgagcg cgccgcgcgg gatgtcctcc agccgctgcc
     2401 cgtcgatgcg gatcgtgccc tcccacgggg cgtacaggcc cgatatgagc ctggagaccg
     2461 tggacttgcc gctgcccgag ccgccgacca gggccacctg ctggcccggg ccgaccgtca
     2521 gggagaagcc ggtgagcagg ggtttgtcga gcgggctgta gccgaacgtg atgttctcca
     2581 gctcgacatg accctggagc cggcgggtgg actcgccgct gccggagcgg gcgtagagcg
     2641 ggtcggtctg gaagttctcg acgtccttga gccgggccac gtcggcggcg aagtcctgga
     2701 tgcggcccgc gacgccgttg agccgggtga ggggcgcggt gaagcgggtg accagggcct
     2761 ggaaggcgac gagcagaccg acggagatgt gcccctcgac cgcccgcaga ccgccgatcc
     2821 acaggatcag cgcggagttg agcgtcgcga gcgtcggtgc gaccacgccc agccaggcgc
     2881 tcggcacccc gaggcgctgc tgctcctcca gagtggtcgc gtgctgcccg gcccacttgc
     2941 ggaagtagcc gtcctccccg ccggtcgcct tcatcgtctc gatcaactgg agcccggtgt
     3001 aggcggtgtt ggtgaggcgc gcgttgtcgg cgcgcagctt cgccgtacgg gtggcgcgca
     3061 gccggatcac cacgcgcatc gcgatcacgt tgagcagcgc gacgccgatg cccacggccg
     3121 tgagctgtgg gtcgtaggtg tagaggagca ccgcgtacag gacgaccacg atcgcgtcca
     3181 cgccggccgc cgcgaggtcc cgggccaggg tctcggccac cgcgtcgttc gactggagcc
     3241 gctgcaccag gtcggccggg ctgcgctggg agaagaaggt gacgggcagc cgcagcagat
     3301 ggcgcaggaa gcgggcgctg gagagggtgg aggagatgat ccggccgtgc agcaggttcg
     3361 cctgctggag ccaggtcagc acgacggtca gcgccacaca ggcgcccatc gacgcgaaca
     3421 gcacgcccag caacgaggtc cggccgccga tgagatacgt gtcgatgtac gtccggctca
     3481 gcgcggggac cgccgcgccg accgcgacca gcagcaggct cgccagcacg gccgcgggca
     3541 tcgtgcccga ggtgccgcgc agccgggccg gcatggcgcc caggacgccc ggcttgcggc
     3601 cgcccttgtg gaagtccggc cccggctcca tgaccagaac cacacccgtg aagctggtgt
     3661 cgaagtcctc catcggcacg aaacggcggc ccttgccggg gtcgttgatg tgcacgccgc
     3721 gccgtccgaa gcggcggccc atgccgtcgt agacgacgta gtggttgaac tcccagaaca
     3781 ggatcgcggg cgccttcacc tcggcgagcg cggccgtgtc catctgcatg cccttggccg
     3841 tgaggccgta actgcgcgcc gccttgagga ggttgctggc gcgcgagccg tcccgggaga
     3901 caccgcaggc gatgcgcagc tcttcgaggg ggaggtggcg gccgtagtgg ccgagcacca
     3961 tggccaggga ggcggcgccg cactccacgg cctccatctg gaggacggtg ggggtgcgga
     4021 ccgtcttccc cttcgccttg gggactgtgc gcttgggcgg ggcggtgcgg cgtctgctcc
     4081 gggtgtctgg tgcggtggtc acggcaggag ccaatcgacg gggcgctgat cggccaggcg
     4141 gatcgaaccc gtggccaggg tcatggaggt gagcgcgaac ggcggcccgt cggccgagga
     4201 ccacttcagg ccgctcttcg tcgcggcgga gcggtcgagg cggaccagga cggccaccgg
     4261 cctgcccttc ttggagagct gttcgccgag ttggctgtca ccgaggaagg aggagatctg
     4321 ctggggggtc tgcacgctcc ggccgaccgc cttcacatgg ccgcgcagta ccccgtactg
     4381 ctgggtcggc accgactgca cggtgaggtc gaccgcggcg ttcgcgggga tggtggcggc
     4441 gctctcggcg ggcacgtaca ccgtcgcgta gagcggatcg tcggcgtggg cgaccttctc
     4501 cacggcggcg acgttcgcgc cggtcgagat gatcgcgccg atggtggcgg cgagcgcggt
     4561 gacgcgtccc gcggcgaccg tgcggacgac ggtcgtaccg ccctgggtcg tacggacctt
     4621 gagcaccggc gcgttcgcgg cgagccgttc gccctcctgg gcgacgacct cggtgacctg
     4681 ccccgcgacg gggctctgca ggatgtagct gccctcgccg tgggtgagga cggcgggcgc
     4741 gctcacggtg gacgccaccg tgcccgtcac ggcccagacg gacgccgccg ccatgacgac
     4801 caccgtcacg gacagggcga gccagccctg ggggcgggcg aagcgcaccg gaaggtcgag
     4861 ctcttcgggc gactgcagct tggcgagggc ctgttggcgg aactgcacgg gacttccctc
     4921 acctgttcga gaggtttacg gcatccgaga agtcccggaa ccggggagtg gttccgggac
     4981 tcaacggcac tgaaacgcga tcagagaccg gcgaccaggc ccgtgaccgg ggcggtgttg
     5041 aggccggtga caccctcgac ggtgccgaca accgtgttga ccaggccgga gaccggggca
     5101 acaccgtcga ccaggccggt gacggtgccg acggcgttca gcgacagacc gccggagacg
     5161 ttgtcgaggt cggcgtccga gatctcggcg gtggcaacct ggggggtgga gttcatgagg
     5221 gaacttccct tcgtatggat attcataagg gggagagcgg cccccctctg gggacagatg
     5281 acggccgcca ccgcgggggt gcggcacccg attccgggcg ctgtgcggcg cccgttcccg
     5341 gatgcctggc tgcgacctcc gcggtgcaac ggatcaaagc acgctcgagg tgcgcgcatc
     5401 caatcaaccg gggctctcac ctgcggactt gagcgtggcc agggcccaac cgtgcaggtg
     5461 tgcgcacgtc tcggcagtca gttcttcaca tgctgcacgg cattgttccg tccccgcgct
     5521 tgtcgccccg cactcgaaag ggacagtccc accgcaatgg cgcggagggg ggcgcgcgag
     5581 tgtgcagatc tgctgtccac cgtgacgcgc ctgcgtattc gatgtgcaga ttccctgaag
     5641 ccaggattcc gttcctgccg gaagacggac cgtcaccgat cggtagcgca acgtgccgga
     5701 tccgccgctc actcggtgta atggcccgat tgcctggtat ttcatgggtt tggtcgagcc
     5761 aactcagctc ttttttaaac acagttgaac agccctcgcg gcccacgcgt atcaacaggc
     5821 atccaggcgc cccctagtca gccgccggac ggtggcctcg accccgtccc caggaggtca
     5881 aagagttgag tcacaaaagg attcccaagc gcaaggccgc catcgctgtc ggaggcgtcg
     5941 cggcgctcgg agcggcggct ctgctgctgc cccacgccaa cgcctcgcag accgacgcga
     6001 agggcgccgc tcctaagacg ctgaagtccg cggacgcctc gaacctggcc tcgctcctcg
     6061 cctcccagct cggtgacgcc ttcggcggcg cgtactggga cgcctcgaag cagcaggtca
     6121 tcgtcaatgt cgtcggcaac aacagcaatg tcgtcaacac cgtcgagaag gccggcgccg
     6181 ttccccgcag cgtcaacaac agcctgtccg cgctcaagac ggctgccaag acactgaagt
     6241 ccgacgcgac catccccggc accgcctggt cgatcgaccc caagacgaac caggtccagg
     6301 tcaccgccga cagcaccgtc acgggtgcga agtgggccaa gctgacgtcg accgtcgact
     6361 cgctcggctc tggcgtggcc acggtcaaga agtccgccgg tacgttcaag acgttcgtgt
     6421 cgggcggtga cgccatcttc gcccaggcga acggcggcgg cgtccgctgc tccctcggct
     6481 tcaacgtcac agcgagcgac ggcgcccccg ccttcctcac cgccgggcac tgcggtgtcg
     6541 cggccaagca gtggtcggac tcgcagaacg gccagccgat cgcgaccgtc gaccaggcca
     6601 ccttccccgg cgccggcgac ttctcgctcg tgaagtacga cgaccccgcc acccagacgg
     6661 tgagcgaggt gaacgaaggc aacgggaaga ccgtccagat cacccaggcg gcggacgcca
     6721 cggtcggtca gcaggtcctc cggatgggca gcaccaccgg tctgcacgac ggctcggtca
     6781 ccggtctcga cgccaccgtc aacttccaga gcgaaaccgt tcccggcggt gtcgacaccg
     6841 tcaccggtct catacagacc aacgtctgcg ccgaggcggg cgacagcggc ggctccctgt
     6901 tcaccgcgga cggcagcgcg gtcggactga cctccggcgg cagcggcgac tgcaccgccg
     6961 gtggcgagac cttcttccag cccgtgaccg ccgccctcca ggcgaccggc gcgacgctcg
     7021 gcgcgggtgg cgccgcgggt gccggcggcg cgagcgccgc ggcgaccgac ccggcggcca
     7081 ccgaccccgc ggccaccgac ccggcagcga ccgatccggc ggcgaccgac cccgcggcca
     7141 ccgacccggc agccacggac ccggcggcga ccgaccccgc ggccaccgac ccggcagcca
     7201 ccgacccggc cgcgggcggc cagtccggga ccggcagcgg ccagtccagc accggtatga
     7261 acgccggctc cggcctggtg accagcaccc cgtgacaccg gtgaccacga gccactgacc
     7321 cggccgtgcc aacacggccc ggtcggcagt ggaagggtcc ggccctccgg cgggagggcc
     7381 ggaccccacc gtgtttcccc cgccgctcac gagagggccg gacgccgagg gtttccggta
     7441 ccgctcagtc gtgcggacgc acccgcaaca gaagcagcgc cacgtcgtcg agccgctcct
     7501 gcgtcaccgc cccggtctgc tcgacgagac ggtcggccag cgcgttcagc gacaggtcac
     7561 cgccctcggc gagtttgcga ccgaggtcgg ccagggcgtc ctcgatgtcc acgccgggcg
     7621 actcgatcag accgtcggtg tacagggcga ggaccgaacc ggggacgagc gggacctcgg
     7681 tcgtcggata cgtggcggcc gcgtcgatcc ccagcagtgg cccaccggcc aggtcgagca
     7741 cccggacccg tccgtccggc cgcagcagca gcggcggcgg atgacccgcg cgcgacatga
     7801 cggccacctc gcgcgccggg tcgagacgca gatagagaca gctcgcgaac agctcggccc
     7861 ccaggtcgat cagcagccgg ttggtgctgc gcatgacctc ctccggcggc tggccgacgg
     7921 tcgtgtacgc ccgtacggcc gtgcggatct gccccatcag gcccgccgcc gtcacgttgt
     7981 gcccctgcac gtcaccgatg accgcggcgg ccagaccgtg cgagggcacc aggtcgtaga
     8041 agtccccgcc gatctccatc ccctgagtgg ccgggagata gcgcgcggcc gcctcgatcg
     8101 agggcagcgt gggcaacgag tgcggcaaca gcgcggcttg cagaccatgc gccagctgca
     8161 gcttggcgtc gtagagcagg gcccgctcca gggcctgcgc gatcagaccg cagaggctgg
     8221 tcagtacggc acgctcctcc gccgggaagg tgtgcggttc cgcgtacccg aggacgcagg
     8281 tgcccaccgg ccgtccggac gcgatcagcg gcagatacgc ccacgccgcc atcccgtcgg
     8341 gcgtcgcgct ccggtccggg tagaggcgct ccagctgctg acgggagtcg aagaacgccg
     8401 gcaccccggt cttgagggcc tgggtgcccg gagtctgcgc gctcagtggc accccgtgcc
     8461 agcgctccac gatgtgcgcg tccgcgtaac cccggtggcc gagcacgtgc aggcggccgg
     8521 atcgcgagcc gaggacgacc agggccttgc tgccgacggc cggcgcgatc tcgtccgcca
     8581 ccagctgcac cacgtcctcg acccccgccg cctgggtgag cgcgcccgcc agactcagca
     8641 cctggctgat ggtcaccagg cgcggggtgg tgtcgtcctc gccgtgccgc gactcgacgc
     8701 gccccatctc ggccaccgcc cgggcccggg agatgcgcac gctcaggccg gtcgtattcg
     8761 gatagagccg gaacgacagc cagttgccgg gcggccgcag cgccacgaac gacgtcacgt
     8821 gctggctgat cagcgcggcc cggtaacggt cctcgtagac ggggtcgttg agccagggca
     8881 ccgacgccca cagctgggtg cccagcagct cgctgaccgg gacgccgagc atgtccgccg
     8941 tcgcggcgtt ggcgaaactg acccggccgt tcaggtccag ggcacacagc ccgtacggca
     9001 accgcgccac catccgcgcc gcctccagcg tgccgagcac gccggtggcc ggagccgcgg
     9061 acggagccag cagatccggc tcgggatgga ccggccgccg ctccgccgcc gcccgctcca
     9121 gacgcagcgc gagccgggcg caggacgcgg tgagatggtc acgctcccgg tcggagaggt
     9181 ccacgggatg cgagccgggc caggtcacga agacggcgcc gtacacggtg cccgcggtcg
     9241 ccaccgggag ggcggccagc gcgaaggggt acggcaggac cacggcgatc cgggggaagc
     9301 ggcgggccat ctcctcctcg ccaccgaccc agaccagccg ccgctcgcgc accgccaccg
     9361 cgaccgggat cggcgcgttg agccccaccc gctcccacgg cgccgcgaac gacctgggca
     9421 tgcccgccat gaccgccatc tccagcacgg cctcacccgg cgtcagcagg tacaccgccc
     9481 cggagtgggc gtggacctcc tccatcatcg aggccagcgt cagcgacagc agcggccgcc
     9541 cgaccggcgt ccgccgaccc gccggcgcct gtacggaccc ctgccagtcg gacacgccga
     9601 ccacctcctc gcagggccgc gcgacgggac tcagggatca aggctccctc gtgacggccc
     9661 ttcccgcacg gcgaacgcca cgcgcggcac agggtgccgc ttgcgggctc cgccgcaggc
     9721 ccgacggccc cggaaccgtc gcaggggctg cgcgagcgtc ccggaagcgc tgtaattgcg
     9781 gacgtggtca gtgagggcgc tgcggaacgc ggaaagagga cgttgcgtgc cgaacttgcc
     9841 ctcaagacgc ccaccccgga cctggacccg cgcgagcgac agcgccgcgt gctcgaactg
     9901 gcactcgtct tcgcgggtgc gagcgtcgtc gcggtgtact cgcccaccga gagcggcgac
     9961 gagctgtacc tgtccgagtc ggcaggcgtc cccaggacgc tctacggcct gcgcgacagc
    10021 tatgtcctca ccggcggctc cccggcggtg gacgcgtacc gctcgggccg accgctgtgg
    10081 ctcggcccgg cggagatcgc ccactgcgcc gaagcccgca ggctgccgtc ccaggacttc
    10141 tggctggccg tcctgcccct gccggacggc ggctgcctcg tggcggccgg cgagcgcccg
    10201 ggcggcttcg acgagg
//
