LOCUS       NZ_CP041610            25192 bp    DNA     linear   CON 14-NOV-2023
DEFINITION  Streptomyces sp. RLB3-17 chromosome, complete genome.
ACCESSION   NZ_CP041610
VERSION     NZ_CP041610.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RLB3-17
  ORGANISM  Streptomyces sp. RLB3-17
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66.0x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/14/2023 04:19:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,027
            CDSs (total)                      :: 10,924
            Genes (coding)                    :: 10,421
            CDSs (with protein)               :: 10,421
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 503
            CDSs (without protein)            :: 503
            Pseudo Genes (ambiguous residues) :: 0 of 503
            Pseudo Genes (frameshifted)       :: 178 of 503
            Pseudo Genes (incomplete)         :: 409 of 503
            Pseudo Genes (internal stop)      :: 52 of 503
            Pseudo Genes (multiple problems)  :: 128 of 503
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8920496
            Orig. end                         :: 8945688
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041610.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041610.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25192
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="32"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25192
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25192
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15192](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15192)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(23..826)
                     /locus_tag="FNV62_RS40070"
                     /old_locus_tag="FNV62_40675"
     CDS             complement(23..826)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012948817.1"
                     /locus_tag="FNV62_RS40070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40675"
                     /product="IS5 family transposase"
                     /protein_id="WP_144316550.1"
                     /transl_table=11
                     /translation="MAWVGRLVPDGLWELFQRVVPAAPVRPQGGGRRRYGDREVLAAIL
                     FVATTGCTWRQLPPFFGPSGPTAHRRFTEWSRARVWSKLHRLVLDQLGARGELDWSRCA
                     IDSVNMRALKGGDLTGPNPVDRGKKGSKIHLITERSGLPISIGISAANTHDSQGLEPLV
                     RGIPPIRSRRGPRRRRPAKLHGDKGYDYDHVRQWLRSRNITPRIARKGIESSQRLGRHR
                     WTVERTVAWLAGCRRLHRRYERKAEHFLAFAGIAATLICYRRLGG"
     gene            843..1322
                     /locus_tag="FNV62_RS40075"
                     /old_locus_tag="FNV62_40680"
     CDS             843..1322
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS40075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV62_40680"
                     /product="hypothetical protein"
                     /protein_id="WP_144315921.1"
                     /transl_table=11
                     /translation="MIEPLETTSKPDFLVTRGNEQFVVEAIWKAQKRDAGSYSLPPQLS
                     DAIDRLPSPNFFVSCELHSVGTATPPQRRLKSGLTRWLASLNPDKVIADHEHKVPLPSH
                     TWQEAGWCLTFQAIPRSPGKRGNPSSRTIGVYPSAWAVEDGSERVLDAVTHKGGK"
     misc_feature    1098..1100
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1330..1344)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     gene            2055..2780
                     /locus_tag="FNV62_RS40080"
                     /old_locus_tag="FNV62_40685"
     CDS             2055..2780
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_function="GO:0016018 - cyclosporin A binding [Evidence
                     IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056338.1"
                     /locus_tag="FNV62_RS40080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40685"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_144315922.1"
                     /transl_table=11
                     /translation="MSRALMTALAAAALVVSGGSTTASAYDAPPRTTHGPCQYTQTPDE
                     PASRRVPLPPDPRHTPSHGTVGMAVRTSQGPLPLSLDRAMAPCTVQSFVHLARHRFYDR
                     TVCHRLTAYPTLKVLQCGDPTGTGEGGPGYEYKDELPVDLPPAPSDPTGVRRLYGRGLL
                     AMANAGPNTNGSQFFVVYGNSALRPNYTVFGTVGAAGLKTLDKIAAGGIEPTSQDPAPV
                     DGMPVLRTELLSVRPSCRP"
     gene            complement(2752..3144)
                     /locus_tag="FNV62_RS54760"
     CDS             complement(2752..3144)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS54760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_205523183.1"
                     /transl_table=11
                     /translation="MTAGHLGDFVPERLGGEVGAERGKYAEGDVDAEPSLPGPVDVLQV
                     QQQGELVGDQGGSGAVGGGDRGMANSAFVTAYGDQPDAREGGDAEVVVMQVLPAGRDVA
                     GPNNKPTPLSSGSEGGFIRAGRTAGR"
     gene            3886..4440
                     /locus_tag="FNV62_RS57670"
     CDS             3886..4440
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS57670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_205523184.1"
                     /transl_table=11
                     /translation="MGWEPGNSARMRRRYQHLTGRVLRDTAAKVGGLLWPMAADGGEEA
                     TGAAQASAGGLVYVARIGEYLVPFRDRGHADFLMERWRSERPGQLAEVEEWERWKWERE
                     GHGGPGAVRDRLPNRRVVHHAHAAFLPSGAREPATRLDPWSVDVWEFETDLYPDQVVRW
                     GTLRRVGGVIDVRARARSKEP"
     gene            complement(4575..>5585)
                     /locus_tag="FNV62_RS56120"
                     /pseudo=""
     CDS             complement(4575..>5585)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009316414.1"
                     /locus_tag="FNV62_RS56120"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="DRWGLPPRAVMTTGSVLGVLAVLAIAYAPNLAAFIAAWLLAGVAM
                     AATFYQPAFAALTRWWGGDRVRALTIVTLAGGLASTVFAPLTATLAEHLSWRSTYAVLA
                     LLLALVTIPAHAFALRAPWPPAPAPPSQQDTSSGSVTRSRPFLMLATALTLNSFAMYAV
                     VIALVPLLIARGASPTAAAWALGLGGAGQTLGRTLYATLASRTGVTTRTAALITLGGTT
                     TAAFAMVSGPFPLLVGIAIAAGMVRGNLTLLQATAVSDRWGTTHYGRLSGLLAAPATIA
                     SALAPFAGAALAGPLGGYPGLFIALALASAAAALFAVGGTPSRRQHHTDGTSPSP"
     gene            complement(<5799..6647)
                     /locus_tag="FNV62_RS56125"
                     /pseudo=""
     CDS             complement(<5799..6647)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.3"
                     /locus_tag="FNV62_RS56125"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSPVSPSDHVTPRTALPAAQYAASRHAAWLGAAAIITDEVGRVL
                     LVHPTYRKDDSWLLPGGVVEPGEHPHITCRREITEELGLDLPLSAVLAVHSFSPHHPDL
                     QPGTPCPGEVRFVFDGGTLTPDQAEAIRLPHEELSEYAFLESRDAVQRLRPVDGQIMLA
                     AYRARLGNTATAHLADGRHILDVPALDRHDVHVRYRPLWDSPLNRGPVPGQLPVQQAWA
                     WCFVPDGRVVLVADPGPRGALPMLPGGTVESTDATPEDTLHREAAEEAQLTLADPVRLG
                     WV"
     gene            complement(6709..8649)
                     /locus_tag="FNV62_RS40100"
                     /old_locus_tag="FNV62_40705"
     CDS             complement(6709..8649)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008416914.1"
                     /locus_tag="FNV62_RS40100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40705"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_144315924.1"
                     /transl_table=11
                     /translation="MTSAITQDQPPQPPKGTAPDNEPQEAGVREEEYLYRDESRLQAGS
                     LLTSRTMARRLPSLVRRSVQMAWRVDRGATIGLLVCQIGTGVLAALGLLAVTGTITALI
                     SSGDITERLWDAAPQLAVIAAAAGLRALLGIIVVWLTGRLRPVLGRAAELTMIEAALGA
                     ELAANNKPGYNDAYDIADRGAQVTPDLVEEAQDVLAATATLAAGATVLTVLHPLLLPLL
                     FLACLPQAAAYVRSARVLYLAGLETSGRRRMLGKLRWHMAYQESSEEMRACLAGPFLIG
                     RYRRLAASVNAAERKAVNTGAWMGLAGAVAGGIASTAVWAALLWLLASGRMSLAAGGGA
                     VFALQTATGSVRGIINGGAHLVRTGWYVQDWQNFLDNAHGQAMTDSRGTAPVAVPLERF
                     EVRDVTYRYDGAPKDSLSNVSLHVRRGEIVALVGENGSGKTTLSRLLCGLLLPTEGDVA
                     WDHASTADLDPWGSWEHVALVPQKFTYLPLTMRDNITFGQGDTSDAALLAACEASGAAE
                     MLPGLRSGLNTLLTSEWFGGQQLSGGQWQRLVLTRAFHRQAALLVMDEPTAALDARAEH
                     RIFAGLRELAKDRAILLITHRLTNVAVADRIVVLDEGRIVQEGTYAQLTQEPGLFRTLW
                     ELQRRMSGVAS"
     misc_feature    complement(8637..8651)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(8962..9996)
                     /locus_tag="FNV62_RS40105"
                     /old_locus_tag="FNV62_40710"
     CDS             complement(8962..9996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346481.1"
                     /locus_tag="FNV62_RS40105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40710"
                     /product="hypothetical protein"
                     /protein_id="WP_144315925.1"
                     /transl_table=11
                     /translation="MIPAIASRIPLVRRTKAPALPLEERINHLTGLTVAPAGAGHHDLV
                     ARTCGVLNYAALIASDVGLPDLAEDLCWRQHQVFANAGRLSGRVAVMSLMPLVNLSRLQ
                     TRAGHGELAYGLLYCLNDAARHRNKTDIDGRTVDLSALTGTDEDHRTVCQELYVTLLVD
                     GARALAQIGRWTEAADAMAQHRGIGNRLLDGRQIKIMAMMEQGLDQQARDLIGTTQPAE
                     PWERGIALLLHAHCRPADAPVLEPDLDRTLDAAVQLLAHPDPPTAAFQTRTGLSALELD
                     RTGRHAARVLDSLVSVARLDAYAARDALHHPVAASALDDRATDALNAVIATAGLGSGVL
                     SAHH"
     gene            complement(10001..12046)
                     /gene="fxlM"
                     /locus_tag="FNV62_RS40110"
                     /old_locus_tag="FNV62_40715"
     CDS             complement(10001..12046)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="FNV62_RS40110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40715"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_144315926.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.5e-16, bitscore:
                     58.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.5e-40, bitscore: 138.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFDDENLPIPPDMSWWHASVAFPDPHTDAARALATALAGRRFHF
                     LRKDAGVRLRTEQPATGLLDQLVADRVITGWTGGIYEPETHAFGGPEGMEVAHDVFCAD
                     SPAALAETGIPGARERSVMLLSAMIREAGLDPFEAGDVYARWAALRPTVTPPQGTALEQ
                     AVSAMRRLMNTDAARRPDAEAGWGERVAAFEDAGRRLRRLVADGRLIRGIRGVIAHHAI
                     FAFNRAGVPADAQAATAWLGRHVAFSAGEGADVCTRKSVPADPSLPRMETTVTPVTDPN
                     QLREALAQRLVDSGHLRSQAAIDAFRTTDRHAFLPGVDLESAYKEDAVPIKHDEHGEMI
                     SCISAPSIVATQLEQLGAQPGHKVLEAGAATGYNAALLGKIVSPGGQVWTLDVDQDLVA
                     GASQHLAEAGVDNATAVMADGAAGLPEHAPYDRIIFTVGAGDVPVKILDQLAPGGRLVL
                     PMRIRGSISRSFAFERDGDTWKTVSCEMATFIPLRKGVCDDVYTLVPMAGEGNVRLETF
                     SEQDVDRDALRTVLDQQQTKLYTGVKFRQGSAWEWLYLYLACVLPNGLSRLPGQRPGFT
                     PHFGWGSMAAPDGGSLSYLTIREGEDEKGRYWEVGVIGHGEGGADLAERVVSEIRAWDA
                     TGGNDAPEPGFRMAVADSRDRLTADDPRFVVDKPYSRLVVDWARKG"
     gene            complement(12086..13156)
                     /locus_tag="FNV62_RS40115"
                     /old_locus_tag="FNV62_40720"
     CDS             complement(12086..13156)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326267.1"
                     /locus_tag="FNV62_RS40115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40720"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_143609760.1"
                     /sec_met_domain="LANC_like (E-value: 5.1e-30, bitscore:
                     103.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTVPRTQDLSEGALGMALLDIERRDLSTARRHLAQATVRGVS
                     TGSNASLFHGAPALEFVLARAHGAGDDVRAAVDRVVDARLAAAHRRQAAGALPHLAEWD
                     LIRGLTGLAALLLSRRPIAPRLPDVLACLVALAHPARGEGRMLPGWWSAVGPDGKEMAG
                     GHGNNGMAHGIAGPLAVLSLALRAGVSVPGQEEAVGTFATWLDRHGAHYWSTAAHLDAD
                     QPPEAEPARQSWCYGQPGIARAQQLAALALGDPARRRAAEDTVETILTDPLRLARITDS
                     TLCHGWAGLLTLTRAVAADSPAPARFTPIIQDLYRRLAADWEHLPKPGFMEGRAGAQLA
                     LNATDTTGWTRVLLLA"
     gene            complement(13153..15192)
                     /locus_tag="FNV62_RS40120"
                     /old_locus_tag="FNV62_40725"
     CDS             complement(13153..15192)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="FNV62_RS40120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40725"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_225900540.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.2e-19,
                     bitscore: 67.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.2e-104,
                     bitscore: 348.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRHRPSLYEAAGQAMLRAAVHTTEPAMPPWPTTTAPVEEWRAWL
                     STVWSDTGFRRTVSQASPHLADQVQAIIDGRTPKVRRMRRAALATARYAIRYARRSTPY
                     GLFAGVAPLGFAQVTSVRIGDEHQAVARPEPVGLEEMLSAWESDAARMADAEVCVNTLI
                     CQRDQHIHVPSEGDAEFRLALSPALRLVLDVARSPIGYRQLSDKLAAEFPAVSGTARDR
                     LLDELLRVRLLRSSLRAPATVADPTDVLPPAARAQAAGLRTACDLRLDADVRLPEQVLT
                     EVETAATVLARLVTHPTGTPTWRRWIEQFSERYGENTAVPVDVATDPDRGVGFPAGFVT
                     ASEPPRPMSRRDRLLLELAGTAAAEGSRTVAVTGAMIEELEAAAGDKPHGLAPHLELAA
                     QVHATSVPALDRGDFRLRVLTVSRSAGSMTGRFWHLFPGTKEAYANLPTVDPEAELAQL
                     SFHAGRVPADLLTRAPQALPRIVSVGEFRRPEPHVLFPRDLSVTVADGRPQLVESATGK
                     PLELLAPTAINFLWNNYTPPMARFLGEISRAASPQVTWFDWGAAWTLPFTPALTYRRTI
                     LTAARWKIRSRTLPARTAPFQQWADQLHAWRARFRVPERVLLAEDDQQLPLDLTRDVDL
                     DLLRAHLDASPFGIATLHDAPPPDADGWIGGRAHSIVVPLARRS"
     misc_feature    complement(14443..14445)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14473..14724)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FNV62_RS40120_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.60E-21"
                     /identifier="RREFam001.1"
                     /label="FNV62_RS40120"
                     /locus_tag="FNV62_RS40120"
                     /protein_end="240"
                     /protein_start="156"
                     /score="67.8"
                     /tool="antismash"
                     /translation="VCVNTLICQRDQHIHVPSEGDAEFRLALSPALRLVLDVARSPIGY
                     RQLSDKLAAEFPAVSGTARDRLLDELLRVRLLRSSLRAP"
     gene            complement(15280..15468)
                     /locus_tag="FNV62_RS40125"
                     /old_locus_tag="FNV62_40730"
     CDS             complement(15280..15468)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="FNV62_RS40125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40730"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_057608338.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.5e-15, bitscore:
                     55.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVQTERPTAPVQSDLATTDETDPFGLDITFIEGTPATETVLMC
                     STGDTCGSSCPSACTTS"
     CDS_motif       complement(15349..15468)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAVQTERPTAPVQSDLATTDETDPFGLDITFIEGTPATE"
                     /locus_tag="FNV62_RS40125_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15280..15348)
                     /prepeptide="core"
                     /locus_tag="FNV62_RS40125_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-9.90"
                     /molecular_weight="1932.2"
                     /monoisotopic_mass="1930.8"
                     /core_sequence="TVLMCSTGDTCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAVQTERPTAPVQSDLATTDETDPFGLDITFIEGTPATE"
                     /leader_location="[15348:15468](-)"
                     /alternative_weights="1950.2"
                     /alternative_weights="1968.2"
                     /alternative_weights="1986.2"
                     /alternative_weights="2004.2"
                     /alternative_weights="2022.3"
                     /alternative_weights="2040.3"
     gene            complement(15601..16068)
                     /locus_tag="FNV62_RS40130"
                     /old_locus_tag="FNV62_40735"
     CDS             complement(15601..16068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491161.1"
                     /locus_tag="FNV62_RS40130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40735"
                     /product="DUF6082 family protein"
                     /protein_id="WP_143609761.1"
                     /transl_table=11
                     /translation="MKLTTAVLAAGAAVSLTTAVVGAVRLRQDARHQTERNEAVVARNQ
                     LDWLAQMSTNADLAKLWAPEDMDVEEYMQLLHANQQICTLSLRDRLGFVRDGQLPFYAS
                     TLMNSDVCQRYWARFGDLRTQEAEGDERAEHFTKVLNQAAKAHQEAQPVAA"
     gene            complement(16143..16718)
                     /locus_tag="FNV62_RS40135"
                     /old_locus_tag="FNV62_40740"
     CDS             complement(16143..16718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491163.1"
                     /locus_tag="FNV62_RS40135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40740"
                     /product="DUF6624 domain-containing protein"
                     /protein_id="WP_143609762.1"
                     /transl_table=11
                     /translation="MTTDEPQRPDLARELIARATESAAHRAKRVRDQLDAVQLGQGRHT
                     DHANTKVLRRILADHDWPGHRLVGPDAARAAWSIALHSDDEPDFQRAATTLLGRAVQAG
                     DALVQHWAHLHDRALITSGRDQEYGTQLLLRADGIELCPLRAPESVDARRATVGLPPIA
                     VALKAVRRRYTAHNSADEAPTVVLAGAA"
     gene            complement(16715..16984)
                     /locus_tag="FNV62_RS56130"
     CDS             complement(16715..16984)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS56130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_225900541.1"
                     /transl_table=11
                     /translation="MASDFAARVDLHVVRAETLARHALEAEPLAALLRRLTDTGWDVCG
                     SGPGRDGDRVARLKLPAEHRPGLRALISCQVHAPQPAPDDRSNA"
     gene            complement(16992..17363)
                     /locus_tag="FNV62_RS56135"
     CDS             complement(16992..17363)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS56135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_225900542.1"
                     /transl_table=11
                     /translation="MTRPTTPTASEDHSAPVPFTQAPPAAIYEMRMLSTAAEREEAAAL
                     VQDRQRWLTLHGLPVPARADIPAQFREAQTMPAGLFEDGRLLACMIPEHDPDLGWARVR
                     PSSSKASTPCPASPTTSPA"
     gene            complement(17360..17854)
                     /locus_tag="FNV62_RS40145"
                     /old_locus_tag="FNV62_40750"
     CDS             complement(17360..17854)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325327.1"
                     /locus_tag="FNV62_RS40145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40750"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_164406031.1"
                     /transl_table=11
                     /translation="MTPPVTTSAPITPLTPTLQRVAQHLANGLTPQEIATKTGLSAVTV
                     RQYIRDIRESLHCPPRCKPPVIVHRLFTTQRVAPPTTDRPTPEISSKQLLLLRAVAEHS
                     DTRDIAVAAKIAPADLRAALDQLLADTGAQDTTELVVLAHSWQLLPAEQAAHATRSGAT
                     Q"
     gene            complement(17983..19236)
                     /locus_tag="FNV62_RS40150"
                     /old_locus_tag="FNV62_40755"
     CDS             complement(17983..19236)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325326.1"
                     /locus_tag="FNV62_RS40150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40755"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_144315927.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.4e-21, bitscore:
                     75.0, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.5e-19, bitscore:
                     68.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-31, bitscore:
                     109.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATPTTPPPALRPYLTARHELLWDEADAFAAEHVAPRAARMEAA
                     PGRVERKVADLMAARGWFAVTVPSAFGGLSAGHVAKTILVHRIACVSAAAAAILQATLI
                     PVGALLHFATYEQKGRWLPRVADGSLLLSIAVTEPQAGGHIGGIETTAERAGSEWVITG
                     SKIHIGNSHLAGAHLVVARTAEAGVSASQALTAFMVEANRPGLAVSDHRPGLGLHGFSA
                     GRLDLDHVRVPEDHVVGEIGRGLSVAQSSSILYGRPNLAAVSLGIHEAIVATTAARLKT
                     RPRYRGTLSDLPVLRDRIGGMEARLCASRILAYQSVHLLDQGLPCDADLINAKYLGHQW
                     AVQSAQDAMELHGAHALDRDYVLQRLWRDIQHTYPPAGTGEVQRIRLADAAFDEDHIQW
                     SERLAAEAAWARPGPTAA"
     gene            complement(19320..19955)
                     /locus_tag="FNV62_RS40155"
                     /old_locus_tag="FNV62_40760"
     CDS             complement(19320..19955)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325325.1"
                     /locus_tag="FNV62_RS40155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40760"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_144315928.1"
                     /transl_table=11
                     /translation="MTYQPTNPYLGPQTPPTQALPRRNMRDLALGPSVPAAAVTGPQAQ
                     QTTELARRYELIERLGMPTAASDDFDEMARDMATQAGFLYGFVNLFLEEQTFVGLHQPS
                     ADSGYVIVGRTMSRDHGWCPEVMARKKALPLHDVHASPRFSSNHVVDAVGIRSYFGAPL
                     IHESGTVLGTVCVIDPEKRPLSEARRLRDIVINAGTQVMDHIARAPIR"
     gene            complement(19955..20542)
                     /locus_tag="FNV62_RS40160"
                     /old_locus_tag="FNV62_40765"
     CDS             complement(19955..20542)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579868.1"
                     /locus_tag="FNV62_RS40160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40765"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_164406032.1"
                     /transl_table=11
                     /translation="MLKIVIAGGFGAGKTTAVGAVSEITPLSTEEYLTEASADVDSLEG
                     VEAKQTTTVAFDFGRLSLPDAPVPLELFLFGTPGQDRFVDLWYDLSRGAVGAVVLVDTR
                     RLESSFTPVSFFEDIGLPFVVAVNQFDGAHRYHPEQIRTALELPASVPVVTCDARDPNH
                     IAGVLLTLVGHAVRNAAAGPVRPTPTTTLQDA"
     gene            complement(20595..21008)
                     /locus_tag="FNV62_RS40165"
                     /old_locus_tag="FNV62_40770"
     CDS             complement(20595..21008)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491176.1"
                     /locus_tag="FNV62_RS40165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40770"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_143609765.1"
                     /transl_table=11
                     /translation="MTTHGRAAEDSTFVRTYTLTRGRTKPRHLLGLETVLDAGPGRPGP
                     GQAEECEDILTLCRERRRSVTELAGRLGRPVTAVKILVSDLLDADALVVPVTSPYAAAD
                     TDADAGPSPQLLAALSAGLKRKWPDALAYPQAG"
     gene            complement(21005..21520)
                     /locus_tag="FNV62_RS40170"
                     /old_locus_tag="FNV62_40775"
     CDS             complement(21005..21520)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031324.1"
                     /locus_tag="FNV62_RS40170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40775"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_144315929.1"
                     /transl_table=11
                     /translation="MSTHPAMNNVTGDAPASETTASGQRDNMAWLLRQFASDVPGVTHA
                     VLLSRDGLRLLDSDVDKDWADELSAALSGVASLAANITGPSHKKRPARQVVIERDDCLF
                     FVQSAGHSTAFENHPGNERGVVDTVLAVIATTDADAGTVGYETGRLVQKFAPYMQIPVR
                     VGTGAEVR"
     gene            complement(21594..23111)
                     /locus_tag="FNV62_RS40175"
                     /old_locus_tag="FNV62_40780"
     CDS             complement(21594..23111)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143015.1"
                     /locus_tag="FNV62_RS40175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40780"
                     /product="ATP-binding protein"
                     /protein_id="WP_144315930.1"
                     /transl_table=11
                     /translation="MPDSAFPARPAATGHRRRRPPIDAFTLHRVRRAVALPLVLLAALL
                     GAAFPLWSVSAVGPGWLLVGLVCGLAGVATVAARGARTAAGAMQTAAEEARAAALTAVA
                     GAAAAVEKSVQWSADELCRGGRPPLPDMQAPPSASPNAEINKALSAVQAQAIASLIRVH
                     DESQSVVLLEVLRRLAMREHALVGKALQALSQLEMLTDDPELLAKIFEIDHLVTRMRRQ
                     VESTAVLGGQSLRSVRRPVPVATALRGAVSEVVQYPRVAVAAGSVGAELGLPGHVGPDL
                     THLLAELIENACECSDPATKVMVRAQRVANGLAVEVEDRAIPMHPQTRAQMNHLLKAPD
                     EVDVSGQVRAGQLGLLVAAKIAQSHGLSVLLQENVTGGTTALVVIPARLLVAIPSVDDA
                     SALPKEARPSAPQPRQVAATPAIPTAGQVTRPGTAGAPGAAEAGHSADAPALPTRRRQV
                     GSFHPPRQREQAPVTAATPGLAAAFRNGIQAGGAAGSPTASTEQPRP"
     gene            complement(23138..25039)
                     /locus_tag="FNV62_RS40180"
                     /old_locus_tag="FNV62_40785"
     CDS             complement(23138..25039)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491181.1"
                     /locus_tag="FNV62_RS40180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_40785"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_144315931.1"
                     /transl_table=11
                     /translation="MKRLPRIEQYGLIGDMQTSAHVCDDGSIDWLCLPRFDSPAVFASL
                     LGTQKHGTWRIAPAAPAGRSSSEAVAERRYRGDSLVLESVWRTQAGSVRVLDFMPPRDG
                     APQVIRIVEGLTGEVSMVSAMRPRPGYGGVSPWIHEVGGRMVAEAGADALWLDTCVQQV
                     EKDGVIVSAFSVAARQSVAFVLSWCPSHATAPDVPDPEAALSETLTFWQDWTRECTYEG
                     PYREPVVRSSIALKAMTYGPSGGIVAAPTTSLPEEIGGNRNWDYRFTWLRDASTTLATL
                     LGTGYRQEAQAWRRWLLRAVAGDPENLQIMYGITGERDLRERVLPWLPGYEGSAPVRVG
                     NGAEDQLQLDVYGEVIETLYLAHESGVAHCADTAVLHQRLVEHLAQRWQDPDEGIWEIR
                     GARRHFVHSKVMAWVAIDRTIRLVEAGSLHMDLDYLVELRAKIHHEVCTKGFDPVRNTF
                     TQSYGSQELDAATLLIPRVGFLPPDDPSVVGTVDAVPRELSTPDGLVRRYPTIGDHAGV
                     DGLTGDEGTFVLCSFWLVDALALTGRLDEAHALFERLLALRNDLGLLAEEYDPVQQRQL
                     GNFPRAFSHMGLIQSARLLQLLATQSSHHRGAVAVPTPRSTSRSTRQTCADLTPQHA"
     misc_feature    complement(24227..24229)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 cctcggagtc gcatgaaccg gctcacccac ccagacgccg gtagcagatg agggtggcgg
       61 cgatgccggc gaaggcgagg aagtgttcgg ccttgcgctc gtagcgccgg tgcagacggc
      121 ggcacccggc aagccaggcc accgtcctct ccacggtcca gcggtggcgg cccaggcgct
      181 gggaggactc gatgcccttg cgggcgatgc gcggggtgat gttccgagag cgcagccatt
      241 gccgcacgtg gtcgtagtcg tagcccttat cgccatggag tttggcgggg cgtcgtcgac
      301 gcggtccgcg gcgggagcgg atcggcggga taccgcgtac gaggggttcg agaccctggc
      361 tgtcatgggt gttggcggcg gagattccga tcgagatggg cagaccggac cgctcggtga
      421 tcaagtggat ctttgatccc ttcttgccgc gatctacggg attcggacct gtcaggtccc
      481 cccctttaag ggcccgcatg ttcaccgagt cgatcgcaca ccgcgaccag tccaactcgc
      541 cgcgggcgcc cagttggtcc aggaccaggc ggtggagctt gctccacacc ctggcccggc
      601 tccactcggt gaaccggcgg tgcgcggtcg gtccggacgg accgaagaac ggcggcagtt
      661 gccgccaggt acagcccgtc gtggccacga acaggatcgc cgccagcact tcgcgatcac
      721 cgtaccgccg tcgaccaccg ccctgcggac gcaccggagc agccgggacc acccgctgaa
      781 acaactccca caacccgtcc ggaaccagac gtcctaccca cgccatcacg acggacagcc
      841 tagtgatcga gccacttgag acgacctcta agcccgactt cctggttacg cgcggcaacg
      901 agcagttcgt cgtcgaggcg atctggaagg ctcagaagcg cgacgctggg tcttactcgc
      961 tcccaccgca gttgagcgat gccatcgatc gcttgccgag tccgaacttc ttcgtatcgt
     1021 gcgaactcca cagcgtcggt acggcaacgc cgccgcagag acggctgaag tccgggctca
     1081 cgcgatggct tgcaagctta aaccccgaca aggtcatcgc cgaccatgag cacaaggtgc
     1141 cgcttcccag tcacacttgg caagaggctg gctggtgcct cacgtttcaa gcgatccccc
     1201 gcagcccagg caaacgtggc aatccatcca gcaggacaat cggcgtctac ccctcggcgt
     1261 gggcggtcga ggacggatcg gagcgagtgc tcgacgccgt cacgcacaag ggtgggaagt
     1321 aaggtgacct ggaactgcca ttcatcgtgg cggtaggcca tgcagccgac ttccccgaag
     1381 atgaggacat cgagagagcg ctgtacggga gtacggtcga gtacgcctac gacagcggat
     1441 cgaccttcag ccgaaagccc gatggctact ggactgccac ctacgaccat gcctacagcc
     1501 gtgtcagcgg cgtgctcgtc gtgaacaacc cagcaccctg gacctggacg aaaaacactc
     1561 ccgttctctg gcaaagaccg gatcccgcct cgcttcctgc ccccatcttc cctacctggg
     1621 caaccgcgca actggctggg atccaggtcg agcgccaccc tgcgaatcgc tccgtccaca
     1681 ctgctctcgg tctgccggaa cgctggccga ccggcgacgc cttcccccgg agtgacccga
     1741 gatgactgca gcggcaccgt cagtctcgac agcggcaccc cggtgagatc acctcatgcg
     1801 cacggcagcg ttcggtgggg gcctctgcgt ggactgggga ggccgctcga ccgggttcgg
     1861 ggagcatccg tcgtgcaccg ggtggacgcc ctgatcggcc agccgacgct gtgctgcatc
     1921 cgaacgaagt ggcctgcggc cgcgggccga aggctgggag gtggatttgg cttgcgggcg
     1981 ggttctcgcc cgccgggccg cgctttaggc tgcgaccgct ccgaaatctg gcgatctttt
     2041 ggagggtgtg caggatgagc cgagctctca tgaccgcatt ggcggcagca gcgctggtcg
     2101 tgtccggggg cagcaccacc gcctccgctt acgatgcccc gccgcgaacc acgcacggtc
     2161 cttgccagta cacccagacc ccggacgagc cggcgtcgcg gcgggttccc ctgccgcccg
     2221 acccgcggca cacccccagt cacggcacgg tcggtatggc tgtccggacc agccagggcc
     2281 cgctcccgct gagtctggac cgggcgatgg cgccgtgcac ggtccagagc ttcgtgcacc
     2341 tggcgcggca ccggttctac gaccgtacgg tgtgccatcg gctgacggcg tatccgacgc
     2401 tgaaggtcct gcagtgtggc gacccgaccg gcactgggga gggtgggccg gggtacgagt
     2461 acaaggacga gctgccggtg gacctgccgc cggcaccgag cgatccgacc ggcgtccgtc
     2521 gcctttacgg gcgcggtttg ctggcgatgg ccaacgccgg gccgaacacg aacggttcgc
     2581 agttcttcgt cgtctacggc aactccgcgc tgcgacccaa ctacacggtg ttcggcactg
     2641 tcggtgccgc cggcctgaag acgctcgaca agatcgctgc tggcggtatc gagccaactt
     2701 cgcaggaccc ggcgcctgtc gacggcatgc ccgtgctgcg gaccgagctg ctcagcgtcc
     2761 ggccgtcctg ccggccctga tgaagccgcc ctctgagccg cttgagagtg gagtgggttt
     2821 gttgttcggc ccggcaacat ctcggccggc ggggagcacc tgcatcacta caacttcggc
     2881 atcgccaccc tcgcgggcat cgggctgatc gccgtacgcg gtgacgaacg cgctgttggc
     2941 catcccgcgg tcgccgccgc ctacggcgcc ggaaccgccc tgatcaccga cgagttcgcc
     3001 ctgctgctgg acctgcagga cgtctactgg gccaggcagg gacggctcag cgtcgacgtc
     3061 tccctcggcg tacttgccgc gctcggcacc tacctcaccg ccaagccgtt ctgggacgaa
     3121 atcgccaagg tgacccgccg tcacatcgcc tccgatgcga agcggggcct gtcgtcagcc
     3181 gggtgaggcc ataccgcggc ggtccgtagc gaccattcgg gggctcacag agtcggcttg
     3241 cagagctcgt gtgcctcctt cggatgcgac actgctgtcg gccgtcagag ttgtctgcag
     3301 ttggcgggtc tggacgtacg cggacgtgcg tggacgggtc gagacagcac acgccgccga
     3361 gccattcatc atccgcagac gcccagtccg agaatccatg ggcccgaatg gggtgcctga
     3421 ccaggcagga cactgggcat cgtggcgtcc acttcgatgc cggtgtgatc cgcgtacggc
     3481 agagccgcct gaggccccgc tacaagcacg gctgcggcaa ccggtgcggc cgtaagcccg
     3541 ggtactgccc gcagaagatc aacacccgca aggagaccaa gggaacgaag tccaaggcgg
     3601 gcaagcgccc gatcggtgtc ccagaggaac tcgtgaagct gctccggctg cacaaggaga
     3661 agcaggctcg cgagcgagcc cttgcccgtg acctgtgggt ggagaagggg tacgtgttca
     3721 cctcgccgac cggcgagccg ctgaacccga acaccgacta ccaccggtgg aaggacctgc
     3781 tgaaggctgc cgccgtccgc gacgggccgc ctccacgacg ctcgccacac cgccgcgacc
     3841 gtcctgctca tcctcggtgt ccccgacgcc gtggtggacc ggatcatggg ctgggagccc
     3901 ggcaactccg ctcggatgcg tcgccgttac cagcacctga ccggtcgcgt gctaagggac
     3961 acggccgcca aggtcggcgg tctgctgtgg cccatggccg ctgacggagg agaggaggcc
     4021 accggtgcgg cgcaggcttc cgccgggggt ttggtgtacg tcgctcgcat cggcgagtac
     4081 ctcgtcccct tccgcgatcg tgggcacgcc gacttcctca tggagcgctg gcgctccgaa
     4141 cggcccgggc agttggccga ggtggaggag tgggagcggt ggaagtggga gcgggaaggg
     4201 catggtggcc cgggcgccgt ccgcgaccgc cttcccaacc gccgcgtcgt ccaccatgcc
     4261 cacgccgcct tcctccccag tggggcacgt gagcccgcta ctcgactcga tccctggtcg
     4321 gtggatgtct gggagttcga gacggacctc taccccgacc aggtggtccg ctggggcacc
     4381 cttcgccggg tggggggagt gatcgacgtt cgggcgaggg cacggtcgaa ggagccgtga
     4441 cggcggcctt cgcggcggct tgtgcacagg ctgtggatcg cgcgaaggat ccgggaaagt
     4501 tcggcgacgg cgaggaacgg tagccgtaga tgaggtgggt gggctgtacc aggaacggtg
     4561 cagcccaccg tccgttacgg gctcggagac gtcccgtcgg tgtggtgctg tcgacggctc
     4621 ggggtccctc caaccgcgaa gagggctgct gcggcggagg ccaacgcaag cgcgatgaac
     4681 agaccgggat agccgccgag tggccctgcc agcgcggctc ccgcgaacgg cgccagggca
     4741 gacgcgatgg tggcaggcgc ggccagcagc ccggagaggc gcccgtagtg ggtcgttccc
     4801 caacggtcgg agacagcggt ggcctggagc agggtgaggt tgccgcgcac catgccggct
     4861 gcgatcgcga tccccacgag caaggggaag gggccggaga ccatcgcgaa cgcggcggtc
     4921 gtggtcccgc cgagtgtgat cagggcggcg gtgcgggtgg tgacgccggt gcggctggcg
     4981 agcgtcgcgt acagggtgcg gccgagggtc tgtcctgcgc cgcccaggcc gagggcccag
     5041 gcggcggccg tgggactcgc gccacgtgcg atcagcaagg gcacgagagc gatgacgacc
     5101 gcgtacatgg cgaagctgtt cagcgtgagc gcggtggcga gcatcaggaa tggtcggctg
     5161 cgggtcaccg acccgctgga ggtgtcctgt tgggagggtg gcgccggtgc gggcggccag
     5221 ggtgcccgga gcgcgaaggc gtgggcgggg atggtcacga gggccaggag cagcgcgagt
     5281 acggcgtagg tgctgcgcca gctcaggtgc tcggcgagtg tggcggtcag cggggcgaag
     5341 acggtggagg ccaggccgcc ggcgagcgtg acgatggtga gggcgcggac gcggtcaccg
     5401 ccccaccagc gggtgagggc ggcgaaggcg ggctggtaga aggtggcggc catggccacg
     5461 ccggccagca gccaggcggc gatgaaggcc gcgaggttgg gtgcgtaggc gatggccagc
     5521 acggcgagga cgcccaggac ggagccggtg gtcatcactg cgcgaggggg caggccccac
     5581 cgatcctgtg ctgtttcccc tgcgagctgg gcttgccgcg cgccgggcgg gccccagccc
     5641 agcagggcgg ctgcctgggt gggggtggtg agcaggcggg cgaaggggtg gccggtggcg
     5701 gggtcgacgg ccgccggccc gatggcggtg acccgggcgg ccaggcgcag ccgggcgttg
     5761 ggccccacgc cgccgtagac ctcgccggtc tcgtccagca cccagcccag tcgcaccgga
     5821 tcggccaggg tgagctgggc ttcctcggcg gcttcgcggt gcagggtgtc ctcgggcgtc
     5881 gcgtcggtgc tctccacggt gccgccgggc agcatcggca gcgcgccccg cgggccgggg
     5941 tcggccacga ggacgacccg gccgtcgggg acgaagcacc acgcccaggc ttgctgcacg
     6001 ggcagctgcc cggggacggg gccgcggttg agagggctgt cccacaaggg ccggtagcgg
     6061 acgtgcacgt cgtggcggtc cagcgccggg acgtcgagga tgtgccggcc gtcggcgagg
     6121 tgagcggtgg cggtgttccc gagccgggca cggtaggcgg cgagcatgat ctgcccgtcc
     6181 acggggcgca gccgctgcac cgcgtcccgg ctctccagga aggcgtactc ggacagctcc
     6241 tcgtgcggca ggcggatcgc ctccgcctgg tcgggggtga gggttccccc gtcgaagacg
     6301 aaccggacct ctccggggca gggcgtgccg ggttggaggt cggggtggtg cggggagaag
     6361 gagtggacgg cgagcacggc cgacaggggc agatccaggc ccagttcctc ggtgatctcg
     6421 cgccggcagg tgatgtgcgg gtgttcgccg ggttcgacga cgcctccggg cagcagccac
     6481 gagtcgtcct tgcggtaggt ggggtgcacc agcaggaccc ggccgacctc gtcggtgatg
     6541 atcgcggcgg cgccgagcca cgccgcatgc cgggatgcgg cgtactgcgc tgcgggcaga
     6601 gccgtacgcg gtgtgacgtg atccgaaggg gagacgggag aggtcacgta tctctgcctt
     6661 tcgcgacggt ggacgggcga gtgcgcagcg cggaccggcg agcggtgatc aggaggcaac
     6721 gccgctcatc cggcgctgca gctcccacag ggtccggaac agaccgggct cctgggtgag
     6781 ttgggcgtag gtgccctcct gaacgatccg cccttcatcc aggaccacga tccggtcggc
     6841 gacagccacg ttggtgagcc ggtgcgtgat cagcaggatg gcgcggtcct tggccagttc
     6901 ccgcaggccg gcgaagatcc ggtgctccgc acgggcgtcg agggcggccg tgggttcatc
     6961 catcaccagc agcgccgcct gccggtggaa cgcgcgagtg aggaccaggc gctgccactg
     7021 cccgccggag agctgctgcc cgccgaacca ctcactggtc aggagggtat tcaggccgga
     7081 gcggaggccc ggcagcatct ccgcggcgcc ggacgcctcg catgcggcga gcagagccgc
     7141 gtcactggtg tcgccctgcc cgaacgtgat gttgtcacgc atcgtcagcg gcaggtacgt
     7201 gaacttctgc ggcaccagcg cgacgtgctc ccacgacccc cacgggtcca ggtccgcggt
     7261 ggaggcgtgg tcccaggcca cgtcgccctc ggtgggcagc agcagcccgc acagcaggcg
     7321 cgagagggtt gtcttgccgg agccgttctc cccgaccagc gccacgatct ccccgcgccg
     7381 cacgtgcagg gagacgttgc tcaggctgtc cttcggggcg ccgtcgtagc ggtaggtgac
     7441 gtcgcggacc tcgaaacgct ccaggggcac ggccacgggc gcggtgccgc gggagtcggt
     7501 catggcctgg ccgtgggcgt tgtcgaggaa gttctgccag tcctgcacgt accagccggt
     7561 gcgcaccagg tgggccccgc cgttgatgat gccgcgcacc gagccggtgg cggtctggag
     7621 agcgaagacg gcgccgccgc cggccgccag gctcatccgc ccggaggcca ggagccacag
     7681 cagcgccgcc cacaccgcgg tcgaggcgat cccgccggcc acggctccgg ccagtcccat
     7741 ccaggcaccg gtgttcacgg cttttcgttc ggccgcgttg accgaggcgg ccagccgccg
     7801 gtaccggccg atcaggaagg ggccggccag gcaggcgcgc atctcctcac tggactcctg
     7861 ataggccatg tgccagcgca gcttgcccag catccggcgg cgcccggagg tctccagccc
     7921 ggcgaggtag agcacgcggg cggagcggac gtaggcggcg gcctgcggca ggcaggcgag
     7981 gaagagcagg ggaaggagca gggggtgcag gacggtcagg acggtggcgc cggccgcgag
     8041 cgtggcggtg gccgcgagga cgtcctgcgc ttcttcgacg aggtcggggg tgacctgggc
     8101 gccgcggtcg gcgatgtcgt aggcgtcgtt gtagccgggc ttgttgttgg cggccaattc
     8161 cgcgccgagc gcggcctcga tcatcgtcag ctccgctgcc cggccgagca ccgggcgcag
     8221 acggccggtc agccagacga cgatgatgcc cagcagggcg cgcaggccgg cggcggcggc
     8281 gatcacggcc agctgcgggg cggcgtccca cagccgctcg gtgatgtcgc ccgaggagat
     8341 cagcgcggtg atcgtgcccg tgacggccag gaggccgagg gccgcgagga cgccggtccc
     8401 gatctggcac accagcaggc cgatggtcgc gccgcggtcc acgcgccagg ccatctgcac
     8461 cgagcgccgc acgagtgagg gaaggcgccg cgccatggtg cgggaggtca gcagggagcc
     8521 ggcctggagc cgtgactcgt cgcggtagag gtattcctct tctcgaacac cggcctcctg
     8581 cggttcgttg tccggcgcgg tccccttggg cggttgtggc ggctggtcct gtgtaatggc
     8641 cgaggtcatc gttcccccta ggacggtcgc tgcggcagag tcgtgaggtc taacgacacg
     8701 gctgcgatat cgaacacacg tcattcggtc gtgctgggga gcccgctatt tcctgcgtca
     8761 gggaaccccg cgggcgcggg atccctggtc tggcttggag cggctgcggg caggaaatgg
     8821 ccgaaacgcc gacaccgcca aacagcgtgg gcagtacggc ggggcatccc gggtcgtccc
     8881 ctcttagctg ggatctggtt cggcctgcag cagcctttcc agttctgtct cggcgtggcc
     8941 gaccgcgccc gtcagagcct cctagtggtg ggcggacagg acgccggatc ccagtccggc
     9001 cgtggcgatc accgcgttaa gcgcgtctgt cgcccggtcg tccagggcgg acgcggcgac
     9061 ggggtggtgc agtgcgtctc gtgcggcgta ggcgtcgagt cgggcgacgc tgacgaggga
     9121 gtcgagtacg cgggcggcat ggcgtccggt gcggtccagt tccagggctg acaggcccgt
     9181 ccgggtctgg aaggcggcgg tcggcggatc ggggtgggca aggagctgga cggctgcatc
     9241 aagggtgcgg tcaaggtcgg gttcaaggac gggggcgtct gcgggtcggc agtgggcgtg
     9301 caggaggagg gcgatgcctc tctcccaagg ctcggcgggc tgggtggtgc cgatcaggtc
     9361 gcgggcctgc tggtccaggc cctgctccat catggccatg atcttgatct ggcggccgtc
     9421 gaggagccgg ttgccgatgc cgcggtgctg ggccatggcg tcggcggcct cggtccaccg
     9481 cccgatctgg gcgagggcgc gggcgccgtc cacgagcagg gtgacgtaca gctcctggca
     9541 caccgtgcgg tggtcctcgt ccgtgccggt cagagcagac aggtcgacgg tgcggccgtc
     9601 gatgtcagtc ttgttccggt gtcgggcagc gtcgttgagg cagtacaaca agccgtaggc
     9661 gagttcgccg tggccggcgc gagtctgcaa ccgggagagg ttgacgagcg gcatcagcga
     9721 catgacggcg acccgtccgc tgaggcgtcc ggcgttggcg aagacctggt gctgccgcca
     9781 gcacagatcc tcggccaggt cgggcaggcc gacgtcggag gcgatgagcg cggcgtagtt
     9841 gaggaccccg caggtgcggg ccaccaggtc atggtggccc gcacctgcgg gcgcgacggt
     9901 cagcccggtg agatggttga tgcgctcctc caaggggagc gcgggcgctt tggtgcggcg
     9961 gaccaggggg atgcggctgg ctatcgcggg gatcatcggc tcagcccttg cgcgcccagt
    10021 cgacgacgag acggctgtag ggcttgtcga cgacgaagcg cgggtcgtct gccgtcagcc
    10081 ggtcacgcga gtccgcgacg gccatccgga agcccggttc gggggcgtcg ttgccgccgg
    10141 tcgcgtccca ggcgcggatc tcgctcacga cgcgctcggc gaggtcggcg ccgccctcgc
    10201 cgtggccgat cacgccgacc tcccagtacc ggcccttctc gtcctcgcct tcgcggatgg
    10261 tcaggtacga gagcgacccg ccgtcggggg cggccatgga cccccacccg aagtgcggag
    10321 tgaacccggg gcgctggccc ggcagccggg acaggccgtt gggcagcacg caggccaggt
    10381 acaggtacag ccactcccac gccgagccct gccggaactt caccccggtg tagagcttgg
    10441 tctgctgctg gtcgaggacg gtacgcagcg cgtcgcggtc gacgtcctgc tcgctgaacg
    10501 tctccaggcg cacgttgccc tcgccggcca tcggcacgag ggtgtacacg tcgtcgcaga
    10561 cgcccttgcg cagcgggatg aaggtggcca tctcgcagga gacggtcttc cacgtgtcgc
    10621 cgtcgcgttc gaaggcgaag ctccgggaga tgctgccgcg gatgcgcatc ggcaggacca
    10681 ggcgtccgcc gggggcgagc tggtcgagga tcttcacggg gacgtcgccg gcgccgacgg
    10741 tgaagatgat ccggtcgtag ggggcgtgct cgggcagccc ggccgcgccg tcggccatca
    10801 ccgcggtggc gttgtcgacg ccggcctcgg cgaggtgctg gctcgcgccg gcgacgaggt
    10861 cctggtcgac gtcgagggtc cacacctgcc cgccggggga gacgatcttg ccgaggaggg
    10921 cggcgttgta gccggttgcg gcgccggctt ccaggacctt gtggccgggc tgggcgccga
    10981 gctgttcgag ctgggtggcg acgatggacg gcgcggagat gcaggagatc atctccccgt
    11041 gctcgtcgtg cttgatcggg accgcgtcct ccttgtacgc gctctccaag tcgacgccgg
    11101 gcaggaaggc gtgccggtcg gtggtgcgga aggcgtcgat ggccgcctgg ctgcgcaggt
    11161 ggccgctgtc gacgagccgc tgggcgaggg cttcgcgcag ctggttgggg tcggtcacgg
    11221 gtgtcacggt ggtctccatt cgagggaggc tagggtccgc gggtacggac ttgcgggtac
    11281 acacgtcagc tccttctccg gcggagaagg cgacgtgacg gccgagccac gcggtggcgg
    11341 cctgcgcgtc ggcaggcacg cccgcgcggt tgaacgcgaa gatcgcgtga tgggcgatga
    11401 cgccccggat tccgcgtatc agtcggccgt cggcgacgag ccggcgcagg cggcggccgg
    11461 cgtcctcgaa cgcggcgacg cgctcgcccc agcccgcctc cgcgtcgggg cgccgggcgg
    11521 cgtccgtgtt catcagccgc cgcatcgcag agacggcttg ctccagcgca gtcccctggg
    11581 gcggggtgac ggtgggccgc agggcggccc accgggcgta cacgtctccg gcttcgaacg
    11641 ggtccagccc ggcctcgcgg atcatggcgg acagcagcat cacgctgcgc tcgcgggcgc
    11701 cggggatgcc ggtctcggcg agcgcggccg ggctgtcggc gcagaacacg tcgtgcgcga
    11761 cctccatgcc ctcggggccg ccgaaggcat gggtctccgg ctcgtagatc ccgcccgtcc
    11821 agccggtgat cacgcggtcg gcgacgagct ggtccagcag gccggtggcg ggctgttcgg
    11881 tgcgcaggcg cacgccggcg tccttgcgca ggaagtggaa gcggcgcccg gccagcgcgg
    11941 tcgccagggc ccgggcggcg tccgtgtgcg ggtcggggaa ggccacggag gcgtgccacc
    12001 aggacatgtc cggagggatc ggcaggttct catcgtcgaa ggtcatgggc agaaaactcc
    12061 ttgcgaggcg gcggggagaa gaaggtcagg cgagcaggag aacgcgggtc cagccggtgg
    12121 tgtcggtggc gttcagggcg agttgggctc cggcgcggcc ttccatgaat ccgggtttgg
    12181 gcaggtgctc ccagtcggcg gccagccgtc ggtacaggtc ctggatgatc ggggtgaagc
    12241 gtgcgggtgc gggactgtcg gcggcgaccg cgcgggtgag ggtcaacagc ccggcccagc
    12301 cgtggcagag agtcgagtcg gtgatgcggg cgagccgcag cgggtcggtc aggatggtct
    12361 cgacggtgtc ctcggccgct cggcgccgtg cggggtcgcc gagggctagc gcggcgagct
    12421 gctgggcgcg ggcgatgccg ggctggccgt agcaccagga ctggcgggcc ggttccgcct
    12481 cgggtggctg gtcggcgtcc aggtgtgctg cagtggacca gtagtgggcg ccgtgccggt
    12541 cgagccaggt cgcgaatgtg ccgacggctt cctcctggcc ggggacgctg actccggcgc
    12601 gcagggcgag ggagagcacg gccaggggcc ccgcgatgcc gtgggccatg ccgttgttgc
    12661 cgtgcccgcc ggccatctcc ttcccgtccg ggccaaccgc cgaccaccac ccgggcagca
    12721 tccggccttc accacgggcg gggtgggcga gcgcgacgag gcaggcgagc acgtcgggca
    12781 gccggggcgc gatcgggcgg cgggacagca gcagggcggc gagtccggtc aggccgcgga
    12841 tgaggtccca ttcggcgagg tggggcagtg cgccggccgc ctgacggcgg tgggcggcgg
    12901 cgagccgggc gtccacgacg cggtcgacgg ccgcgcggac gtcgtcgccg gccccgtggg
    12961 cgcgggccag gacgaactcc agggcgggtg cgccgtggaa gaggctggcg ttactgccgg
    13021 tgctcacccc tcggacggtg gcctgggcga ggtggcggcg ggcggtggac aggtcccggc
    13081 gctcgatgtc gagcagggcc atccccaggg cgccctcgga caggtcctgc gtacggggca
    13141 cggtcgtcgt ggtcatgagc gtctggccag gggaacgacg atgctgtggg cccggccgcc
    13201 gatccacccg tcggcgtccg gcgggggcgc gtcgtgcagg gtggcgatgc cgaaggggct
    13261 ggcgtccagg tgcgctcgca ggaggtccag gtcgacgtcg cgggtgaggt cgaggggcag
    13321 ctgctggtcg tcctcggcga gcaggacccg ctccggcacc cggaaccggg cacgccaggc
    13381 gtggagttgg tccgcccact gctggaatgg ggcggtgcgg gcgggcagcg tgcggctgcg
    13441 gatcttccac cgggcggcgg tgaggatggt gcgccggtag gtgagggccg gggtgaaggg
    13501 cagggtccag gcggcgcccc agtcgaacca ggtcacctgc ggggacgcgg cccggctgat
    13561 ctcgccgagg aagcgggcca tcggcggggt gtagttgttc cacaggaagt tgatggcggt
    13621 gggggccagc agctccagcg gcttgcccgt cgcggactcc accagctggg ggcggccgtc
    13681 ggcgacggtg accgacaggt cgcgggggaa gaggacgtgc ggttcggggc ggcggaattc
    13741 gccgacgctg acgatccggg gcagggcctg gggcgcgcgg gtgagcaggt cggccggcac
    13801 gcgtccggca tggaaggaga gctgcgcgag ttccgcctcc ggatcgacgg tgggcaggtt
    13861 cgcgtacgcc tccttggtgc cggggaagag gtgccagaac cgtccggtca tcgagccggc
    13921 cgagcgggag acagtgagca cgcgcagccg gaagtcgccc cggtccaggg ccggaacaga
    13981 ggtggcgtgg acctgtgctg ccagttcgag gtgaggcgcc aggccgtggg gcttgtcgcc
    14041 ggctgctgct tccagttcct cgatcatcgc cccagtcacc gcgacggtgc ggctgccttc
    14101 ggcggcggcg gttccggcca gctccagcag caggcggtca cgccgggaca tcggccgggg
    14161 cggttcgctc gccgtgacga accctgcagg gaagcccacg ccccggtcgg gatcggtagc
    14221 cacgtccacc ggcaccgcgg tgttctcgcc gtagcgctcg gagaactgct cgatccaccg
    14281 ccgccaggtc ggtgtcccgg tcggatgggt gaccaggcgg gccaggacgg tcgccgcggt
    14341 ctccacttcg gtcagcacct gctcgggcag ccgcacgtcg gcgtccagcc gcaggtcgca
    14401 cgcggtccgc aggccggctg cctgagcgcg cgccgcggga ggtaagacgt cggtggggtc
    14461 ggcgacggtg gcgggcgcgc gcagcgagga gcgcagcagc cgcacccgca gcagttcatc
    14521 gagcagccgg tcgcgcgcgg tgccgctcac ggcggggaac tccgcggcca gcttgtcgga
    14581 caactggcgg tacccgatcg gcgatcgggc cacgtcgagt acgagacgca gcgcggggct
    14641 gagggcgagg cggaactcgg cgtcgccctc ggagggcacg tggatgtgct ggtcgcgctg
    14701 acagatcagg gtgttgacgc agacctcggc gtcggccatg cgcgcagcgt cgctttccca
    14761 ggcgctgagc atctcctcga gtccgaccgg ctcggggcgg gccacggcct ggtgctcgtc
    14821 gccgatgcgg acggacgtca cctgggcgaa gccgagcggg gcgacgccgg cgaacaggcc
    14881 gtagggggtg gagcggcggg cgtagcggat cgcgtagcgg gcggtggcca gcgccgcccg
    14941 gcgcatccgg cgcaccttcg gtgtgcggcc gtcgatgatg gcctgcacct ggtccgccag
    15001 gtgagggctc gcctgcgaca cggtccggcg gaagccggtg tcggaccaca ctgtgctcag
    15061 ccacgcgcgc cactcttcca cgggcgccgt ggtcgtcggc cagggcggca tggcgggctc
    15121 ggtcgtgtgt accgcggcgc gcagcatggc ctgccctgcg gcctcgtaca ggctgggccg
    15181 gtgccgtgtc atcagggctc tcctcatctt ctgcgtggcg ggcggggcgg gccggacggg
    15241 gagagccccg tccggcccgc gttgccgggg tggtccggct tacgaggtgg tgcaggcgct
    15301 ggggcaggag ctgccgcagg tgtcgcccgt gctgcacatc aggaccgtct cggtcgccgg
    15361 cgtgccctcg atgaaggtga tgtcgagccc gaacgggtcg gtctcgtcgg tggttgccag
    15421 gtccgactgc acgggggcgg tcggcctctc cgtctgcacg gcggtcatgc ttgcctcctt
    15481 gtggcgatgg gtggtgcggg atcccgggac ccggtcgggg cccggagctt ggtgccagac
    15541 ggtggcgggc gaaggcgtcg cctggtccag gcggtctggg agtcgatggg acccgtgccg
    15601 tcaggctgct acgggctgcg cttcctggtg ggccttcgcg gcctggttca ggaccttggt
    15661 gaagtgctcg gcgcgttcgt cgccctcggc ctcctgggtg cggaggtctc cgaaacgggc
    15721 ccagtagcgc tggcagacgt cgctgttcat gagcgtcgag gcgtagaagg gcagttgtcc
    15781 gtcgcggacg aagcccaggc ggtcgcgcag gctgagggtg cagatctgct ggttggcatg
    15841 gagcagctgc atgtactcct cgacgtccat gtcctcgggc gcccagagct tggcgaggtc
    15901 ggcgttggtg gacatctgcg ccagccagtc gagctggttg cgggcgacga ccgcctcgtt
    15961 gcgctcggtc tggtgccgcg cgtcctgcct gagccggacg gctccgacca ctgcggtggt
    16021 gagggagacg gcagcaccgg cagcgaggac ggcggtggtg agcttcatct gtcaacgatc
    16081 ctttcgtgga gcggagttgc ggccgggagg ccgactggtg gagaacctgg ggttccgctg
    16141 cttcacgcgg cccccgcgag gacgacggtc ggggcttcat cggcagagtt atgcgcggtg
    16201 taccggcggc gcaccgcctt cagagcgaca gcgatcggcg gcagacccac ggtggccctg
    16261 cgtgcgtcga ctgactccgg cgcgcgcagc gggcacagtt cgatgccgtc ggcgcgcagc
    16321 aggagctggg tgccgtactc ctggtcgcgc ccgctggtga tgagggcgcg gtcgtgaagg
    16381 tgcgcccagt gctggaccag cgcgtcgccg gcctggaccg cacgtcccag cagggtggtg
    16441 gcggcgcgct ggaagtcggg ttcgtcgtcg ctgtgcaggg cgatgctcca cgcggcacgg
    16501 gccgcgtcgg ggccgacgag gcggtgcccg ggccagtcgt ggtcggccag gatgcggcgc
    16561 agcaccttgg tgttggcgtg gtcggtgtgc cggccctgtc cgagttggac ggcgtcgagc
    16621 tggtcgcgca cgcgtttggc ccggtgcgcg gccgattccg tggcgcgggc gatcagctcg
    16681 cgggcgaggt cgggccgctg cggttcgtcg gttgtcacgc gttgctccga tcatccgggg
    16741 ccggctgagg cgcgtggacc tggcagctga tcagcgcgcg gagcccgggg cggtgctcgg
    16801 cggggagttt gaggcgggcg actcgatcgc cgtcgcgtcc ggggccggat ccgcacacgt
    16861 cccagccggt gtccgtgagc cgacgcagaa gggcagcgag gggttcggct tcgagggcgt
    16921 ggcgggccag ggtctcggcc cgtacgacgt ggaggtcgac tcgggcggcg aagtcggacg
    16981 ccacagggtg atcaggcggg tgatgtcgtc ggactggccg ggcagggtgt ggacgctttg
    17041 gaggaagagg gacggaccct ggcccatccg aggtcggggt cgtgctcggg gatcatgcag
    17101 gccagcagcc tcccgtcctc gaacagcccg gcgggcatgg tctgcgcctc gcggaactgc
    17161 gcggggatgt cggctcgggc gggtacgggc aggccgtgca gggtgagcca gcgctggcgg
    17221 tcctggacga gggcggcggc ttcctcgcgc tcggccgcgg tgctcagcat gcgcatctcg
    17281 tagatggcgg ccggcggcgc ctgcgtgaac gggacggggg cggagtggtc ctcgctggcc
    17341 gtgggggtcg tggggcgggt cactgggttg ccccgcttcg cgtcgcgtgg gcggcttgct
    17401 cggccggcag tagctgccag ctgtgcgcca ggaccaccag ttcggtggtg tcctgtgcgc
    17461 ccgtgtcggc gaggagctgg tcgagcgcgg cgcgcaggtc ggccggggcg atcttggcgg
    17521 cgacggcgat gtcgcgggta tcgctgtgct cagcgacggc tcgaagcagc agcagctgct
    17581 tcgagctgat ctccggcgtc ggcctgtcgg tcgtgggagg ggccacccgc tgggtggtga
    17641 acagtcggtg cacgatcacc gggggcttgc agcggggcgg gcagtggagg ctctcgcgga
    17701 tgtcgcggat gtactggcgg acggtgaccg ccgacagtcc tgtctttgtg gcgatctctt
    17761 ggggtgtaag gccgttcgcg aggtgttggg cgacgcgctg cagggtcggt gtcagggggg
    17821 tgatcggtgc gctggtcgtc acgggcgggg tcacgatgtc tctttctcgg ctggaatgga
    17881 cggtcaccgg gatgggtgcc accggtcccc gcgggggacg gggcccggcg gcacgggccc
    17941 gtgcgcggcg gtctggattc acggggtgcc gcgcacgggg gctcatgcgg cggtcgggcc
    18001 ggggcgtgcc caggcagctt cggcggcgag gcgctcggac cactggatgt ggtcctcgtc
    18061 gaaggcggcg tcggccaggc gtatgcgctg gacctcgccg gttccggcgg gcgggtaggt
    18121 gtgctggatg tcgcgccaca ggcgttggag gacgtagtcg cggtcgaggg cgtgggcgcc
    18181 gtgcagttcc atggcgtcct gggcggactg cacggcccac tggtggccga ggtacttggc
    18241 gttgatcagg tcggcgtcgc agggcaggcc ctggtcgagg aggtgcacgg actggtaggc
    18301 gagtatccgg ctggcgcaca ggcgggcctc catgccgccg atgcggtccc gcagtacggg
    18361 caggtcggac agggtgcccc ggtagcgggg acgggtcttg agacgagcag cggtggtggc
    18421 cacgatcgct tcgtgaatgc cgaggctgac ggcggccaga ttgggacggc cgtacaggat
    18481 gctgctgctc tgggccacgc tcagccctcg gccgatctct ccgaccacgt ggtcttcggg
    18541 gacgcggacg tggtcgagat cgaggcggcc ggcggagaag ccgtgcagac cgagacccgg
    18601 gcggtggtcg gagacggcga gcccggggcg gttggcttcg accatgaacg cggtcagtgc
    18661 ctgggaggcg ctcacgcctg cctcggcggt tcgggctacg acgaggtggg ctcccgcgag
    18721 gtggctgttg ccgatatgga tcttgctgcc ggtgatcacc cactcgctgc cggcgcgttc
    18781 ggcggtggtt tcgatgccgc cgatgtgtcc gccggcctgc ggttcggtca cggcgatcga
    18841 caacagcagg gaaccgtccg cgactcgggg cagccagcgg cccttctgtt cgtaggtggc
    18901 gaagtgcagc agggcgccga cggggatcaa ggtggcctgc aggatggccg cggcagctgc
    18961 cgagacgcag gcgatgcggt ggaccaggat ggtcttggcc acgtgtccgg cactcagccc
    19021 gccgaaggcg gacgggacgg tgacggcgaa ccagccccgt gcggccatca ggtcggcgac
    19081 cttgcgctct accctgcccg gagcggcctc catacgcgcg gcgcgcggcg cgacgtgctc
    19141 ggccgcgaag gcgtcggcct cgtcccacag cagttcgtgg cgggcggtga ggtaggggcg
    19201 cagcgccggt ggcggtgtgg tgggtgtggc ggacatggtc tccctctccc tgggtgaagg
    19261 tcgcgacgtg gagcggccgg ggatcgccta cggctcccgg gtggggggtg tggaacggcc
    19321 tagcggatgg gggcgcgggc gatgtggtcc atcacctggg tgccagcgtt gatgacgatg
    19381 tctctgaggc gtcgcgcctc gctcaggggg cgcttctcgg ggtcgatgac gcacaccgtg
    19441 cccagcacgg tgccgctctc gtggatgagc ggggcgccga agtaggagcg gatcccgacc
    19501 gcgtcgacca cgtggttgct gctgaagcga gggctggcgt gcacgtcgtg cagtgggagg
    19561 gccttctttc gggccatgac ctccgggcac cagccgtggt cgcggctcat ggtgcggccg
    19621 acgatgacgt acccgctgtc cgccgacggc tggtgcagtc cgacgaaggt ctgctcctcc
    19681 aggaacagat tgacgaaccc gtacaggaac ccggcctgcg tggccatgtc gcgggccatc
    19741 tcgtcgaagt cgtcgctggc agcggtaggc atgcccaggc gctcgatcag ctcgtaccgc
    19801 cgcgccagtt cggtcgtttg ctgggcctgc gggccggtga cggcggcggc cgggacggac
    19861 ggcccaaggg cgaggtcccg catgttgcgg cgcggtagtg cctgcgtggg cggggtctgc
    19921 ggtccgaggt aggggttggt gggctggtat gtcatcaggc gtcctggagg gtggtagtag
    19981 gtgtggggcg gacggggcct gccgctgcgt ttctcacggc gtggccgacg agggtcagca
    20041 ggacgccggc gatgtggttc gggtcgcggg cgtcgcaggt gaccaccggt acagaggcgg
    20101 gtagttcgag ggcggtacgg atctgttcgg ggtggtagcg gtgtgctccg tcgaactggt
    20161 tcacggcgac gacgaagggc aggccgatgt cttcgaagaa gctgacgggg gtgaagctgc
    20221 tttccaggcg gcgggtgtcg accaggacga ccgcgccgac ggctccgcgg gagaggtcgt
    20281 accagaggtc gacgaaccgg tcctggccgg gcgtgccgaa caggaacagt tccaggggta
    20341 cgggcgcgtc gggcaggctg aggcgaccga agtcgaaggc gaccgtggtg gtctgcttgg
    20401 cctcgacgcc ttccaggctg tccacgtccg cgctcgcttc ggtcaggtac tcctccgtgc
    20461 tcagcggcgt gatctcgctg acggcgccca cggcggtggt cttgcccgcg ccgaagcccc
    20521 cggcgatcac gatcttcagc acggtaggtg caccggcatg tgggtgcgct ggagtccgca
    20581 gcaccacggc cgggtcatcc ggcctggggg taggcgaggg catcgggcca cttccttttc
    20641 aggcccgctg agagggccgc cagcagttgt ggggagggac ctgcatccgc gtccgtgtcg
    20701 gctgcggcat agggggaggt gacggggacg accagggcgt cggcgtctag gaggtccgag
    20761 acgaggatct tgacggcagt gacagggcgg ccgagtcggc ccgccagctc ggtcaccgaa
    20821 cgtcggcgct ctcggcacag ggtgaggatg tcttcgcatt cctcggcctg gcccgggccg
    20881 gggcgcccag gcccggcgtc cagcacggtt tccaggccga gcaggtgccg cggcttggtg
    20941 cgtccgcgcg tcagggtgta ggtccgcacg aacgtcgaat cctcggcagc gcggccgtgt
    21001 gtggtcaccg gacctcagca cccgtgccga cgcggacggg gatctgcatg tagggggcga
    21061 acttctgcac gaggcgcccc gtctcgtacc cgacggtgcc cgcgtcggcg tccgtggtgg
    21121 cgatgacggc gaggaccgtg tccaccacac cgcgttcgtt gccggggtgg ttttcgaagg
    21181 ccgtgctgtg accggcgctc tggacgaaga acaggcagtc gtctcgctcg atgacgacct
    21241 gcctggccgg cctcttcttg tggctggggc cggtgatgtt cgccgcgagg gaggcaactc
    21301 cgctgagcgc ggccgacagt tcgtccgccc agtccttgtc gacgtcgctg tccagcagcc
    21361 gcagcccgtc ccgcgacagc agcacggcgt gggtgacgcc cgggacatcg gaggcgaact
    21421 gacgcagcag ccaggccatg ttgtcccgct gtccgcttgc cgttgtttcg gatgcgggcg
    21481 cgtcgccggt cacgttgttc atcgcggggt gggtgctcat agggatcgct ccagaagggg
    21541 gaagggccag cggatgtaac gggccgccgg gaacgtggaa ggacgggcga ggttcagggc
    21601 ctgggctgct ctgtcgaagc ggtgggagaa ccggcggccc cgccggcctg gatgccgttg
    21661 cggaaggcgg ctgcgagccc tggcgtcgcc gcggtcacgg gggcttgctc ccgctggcgt
    21721 ggtggatgga acgagccgac ctgacgtcta cgcgtgggaa gagcgggcgc atcagcagag
    21781 tgacctgcct ctgcggctcc cggtgcccct gcggtgccgg ggcgtgtgac ctggcctgcc
    21841 gtcgggatgg ctggagtcgc ggcaacctgc cgcggctgcg gcgcggaggg gcgggcttcc
    21901 tttggcagcg cgctcgcatc gtcgacggag ggaatcgcta cgaggagccg tgccggaata
    21961 accaccaggg cggtggtgcc tcctgtcacg ttctcctgta ggagaacgga cagcccgtgg
    22021 gactgggcga tcttcgcggc gaccagcaag ccgagctggc cggctcggac ttggccgctg
    22081 acatcgacct cgtcgggggc tttgagtagg tggttcatct gtgcccgcgt ctgcggatgc
    22141 atggggatgg cccggtcctc gacctcgacc gccagcccgt tcgccacccg ctgcgcacgc
    22201 accatcacct tcgtcgccgg atcggagcac tcgcaggcgt tctcaatcag ctcggccagc
    22261 aggtgcgtca ggtccggacc cacatgtccg ggaagaccca gctcggcgcc cacagacccg
    22321 gccgcgacgg ccacacgcgg atactgcacg acctcggaga ccgcgccgcg cagcgccgtc
    22381 gcgacgggaa caggccggcg cacgctgcgc agggactgcc cgcccagcac cgccgtgctc
    22441 tcgacctggc gacgcatccg cgtcacgagg tgatcgatct cgaagatctt ggccagcagc
    22501 tccgggtcgt cggtcagcat ctccagctgg ctcagtgcct gaagcgcctt gccgaccagg
    22561 gcgtgctcgc gcatggccag acggcgcagc acttctagga ggacgacgga ctgggactcg
    22621 tcgtgcacac gtatcagcga cgcgatggcc tgcgcctgga ctgcactcaa cgccttgttg
    22681 atctcggcgt tcggactggc cgatggtggc gcctgcatgt ccggcagcgg cgggcgtccc
    22741 ccgcggcaca gctcgtccgc cgaccactgc accgacttct cgacggctgc cgctgccccc
    22801 gcgaccgcgg tcagtgccgc tgcccgggcc tcctccgcgg ctgtctgcat ggcccctgcg
    22861 gccgttcgcg ctccgcgagc cgccaccgtg gcgaccccag ccagtccgca gaccaggccg
    22921 accaggagcc agccggggcc taccgcggac accgaccaga gggggaaggc ggcaccgagg
    22981 agcgcggcaa ggagcaccag gggcagtgcc acggcgcggc ggacacggtg cagcgtgaac
    23041 gcgtcgatcg gaggccgccg tctgcggtgg ccggtagcgg ccggccgtgc cgggaaggcg
    23101 ctgtcaggca tgggaatcct cgtcagggtg ggggtggcta agcgtgctgc ggcgtcaggt
    23161 ctgcgcaggt ctggcgtgtg ctgcgtgagg tcgagcgggg cgtcggaacc gcgactgcgc
    23221 cgcggtggtg ggaggactgc gtcgccagga gctgaaggag ccgggcgctc tggatcaggc
    23281 ccatgtggct gaacgcccgc gggaagttgc cgagctggcg ctgctggacg gggtcgtact
    23341 cctcggccag gagcccgagg tcgttgcgca gcgcgaggag gcgttcgaat agggcgtggg
    23401 cctcgtccag tcggccggtc agggccaggg cgtcgacgag ccagaaggag cagaggacga
    23461 atgtgccctc gtctccggtc aggccgtcca ccccggcgtg gtcgccgatg gtcgggtacc
    23521 ggcgtacgag cccgtccggg gtggagagtt cacgaggtac cgcgtccacg gtgccgacga
    23581 cgctcggatc gtccggcggc aggaagccga cgcgggggat cagcagcgtg gcggcatcca
    23641 gctcctgcga gccgtaggac tgggtgaagg tgttgcgcac cgggtcaaag cccttggtgc
    23701 agacctcgtg gtggatcttc gcccgcagtt cgaccaagta gtccaggtcc atgtggaggg
    23761 agccggcctc caccaagcgg atggtgcggt cgatcgccac ccaggccatc accttcgagt
    23821 gcacgaagtg ccggcgtgcc ccgcgaatct cccagatccc ctcgtcggga tcctgccagc
    23881 gctgtgccag gtgctcgacg agtcgctggt gcagcacggc ggtgtcggca cagtgggcca
    23941 caccgctctc gtgcgcgagg tacagggtct cgatcacctc gccgtacacg tcgagctgca
    24001 gctggtcctc tgccccattg ccgacccgca ccggcgctga tccctcgtac ccgggcagcc
    24061 agggcaacac ccgctcccgc aggtcacgct ccccggtgat cccgtacatg atctgcaggt
    24121 tctccgggtc gccggccacg gctcgcagga gccatcgccg ccatgcctgc gcctcttgcc
    24181 ggtatccggt tcccagcagt gtggccagcg tcgtggaggc gtcccgtaac caggtgaagc
    24241 gatagtccca gttccggttt ccgccgatct cctcgggcag cgacgtggtc ggcgccgcga
    24301 cgatcccacc gctcggcccg taggtcatcg ccttcagcgc gatcgatgaa cggaccacgg
    24361 gttcgcgata gggcccctcg taggtgcact cccgtgtcca gtcctgccag aaggtgagcg
    24421 tctcgctgag cgcggcctcc gggtcgggaa cgtcgggcgc cgtcgcgtgg gacgggcacc
    24481 aactgaggac gaacgccacg ctctgccggg cggcgacgga gaaggcactg acgatgacgc
    24541 cgtccttctc cacctgctgg acgcaggtgt cgagccacag agcgtccgcg ccggcctccg
    24601 cgaccatgcg cccaccgacc tcgtgaatcc acgggctgac gccgccgtac cccggccgcg
    24661 gacgcatggc cgagaccatg gagacctcac cggtcaggcc ctcgacgatc cggatcacct
    24721 gaggtgcccc gtcgcgcggt ggcatgaagt ccaggacgcg gaccgacccg gcctgggtgc
    24781 gccataccga ttcaaggacg agcgagtcac cgcggtaccg gcgctcggcg actgcttcgg
    24841 agctggaacg gccagcggga gcggccggag cgatccgcca ggtgccgtgt ttctgcgtgc
    24901 cgagcaggct ggcgaagacg gccggcgagt cgaatcgggg caggcacagc cagtcgatcg
    24961 aaccgtcgtc gcagacgtgg gcactggtct gcatgtcgcc gatcaggccg tactgctcga
    25021 tacgcggaag gcgcttcatc gtgtggatct ccgtaggccc cgcggatccg gggatggctt
    25081 cgggaccgcc gcagcggccg ggaaagtagg aacgagtggc accggtgtca ccggggcggg
    25141 gaagctgcga tctgaggcgg cggggactcc tcgccgggcg cagcagggcc gg
//
