LOCUS       NZ_CP041610            10210 bp    DNA     linear   CON 14-NOV-2023
DEFINITION  Streptomyces sp. RLB3-17 chromosome, complete genome.
ACCESSION   NZ_CP041610
VERSION     NZ_CP041610.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RLB3-17
  ORGANISM  Streptomyces sp. RLB3-17
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66.0x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/14/2023 04:19:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,027
            CDSs (total)                      :: 10,924
            Genes (coding)                    :: 10,421
            CDSs (with protein)               :: 10,421
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 503
            CDSs (without protein)            :: 503
            Pseudo Genes (ambiguous residues) :: 0 of 503
            Pseudo Genes (frameshifted)       :: 178 of 503
            Pseudo Genes (incomplete)         :: 409 of 503
            Pseudo Genes (internal stop)      :: 52 of 503
            Pseudo Genes (multiple problems)  :: 128 of 503
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8590210
            Orig. end                         :: 8600420
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041610.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041610.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10210
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="29"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10210
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10210
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5210](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5210)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    286..299
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.4"
                     /tool="antismash"
     gene            835..1149
                     /locus_tag="FNV62_RS38570"
                     /old_locus_tag="FNV62_39130"
     CDS             835..1149
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025569.3"
                     /locus_tag="FNV62_RS38570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39130"
                     /product="CPCC family cysteine-rich protein"
                     /protein_id="WP_144316542.1"
                     /transl_table=11
                     /translation="MVVRGSAECGPYRCPCCGFITLAERGVFEICTVCRWEDDGQDEHD
                     ASEVHGGPNRGLSLRQARRNFHVFGACDERSAQFARAPLPEEHPDSGTPYGIGTLYSGS
                     "
     gene            complement(1393..1578)
                     /locus_tag="FNV62_RS56030"
     CDS             complement(1393..1578)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS56030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_225900510.1"
                     /transl_table=11
                     /translation="MTVFDGQLLLPDGRLAVGDVEGLTRFVRLVGDRGAWNVRVAVDNP
                     GWEARAIDVTIGWPGT"
     misc_feature    complement(2000..2015)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.2"
                     /tool="antismash"
     gene            complement(2195..2509)
                     /locus_tag="FNV62_RS38580"
                     /old_locus_tag="FNV62_39140"
     CDS             complement(2195..2509)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001979.1"
                     /locus_tag="FNV62_RS38580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39140"
                     /product="DUF6416 domain-containing protein"
                     /protein_id="WP_263986790.1"
                     /transl_table=11
                     /translation="MERAAMFLAELAPQARRVFQHLLRNPGRRIHCTELVDKALGGPNE
                     SDPARRVAGVLSGMSKGHSNSERRLPFYWWEAPEGSAGATYAVRPSVAAVFLATQFDAA
                     "
     misc_feature    complement(2616..2631)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.21"
                     /tool="antismash"
     gene            3006..3341
                     /locus_tag="FNV62_RS38585"
                     /old_locus_tag="FNV62_39145"
     CDS             3006..3341
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029504.1"
                     /locus_tag="FNV62_RS38585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39145"
                     /product="hypothetical protein"
                     /protein_id="WP_143628541.1"
                     /transl_table=11
                     /translation="MDAIFDLPVTSAPEQVVIARFRLSGEEFGERAERAVIFRAERAMA
                     VAVGEAGVGEVEGNEFGGGEAMVYAYGPDAGVLFKVMEPILRGLPFRPAHVVLRHGAAE
                     TQFHVDL"
     gene            complement(3543..3875)
                     /locus_tag="FNV62_RS38590"
                     /old_locus_tag="FNV62_39150"
     CDS             complement(3543..3875)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS38590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV62_39150"
                     /product="hypothetical protein"
                     /protein_id="WP_313905051.1"
                     /transl_table=11
                     /translation="MGEADSFEPRMQVRDLSAPGMILREVDGLLRVDPPEVTMFGMPRR
                     NRRPPAVRLAPGQWLQWQINHRFVGSCDGAWSYQLETFNILYGPAAPDVFLSVPTRRVD
                     ERGPLR"
     gene            4257..4664
                     /locus_tag="FNV62_RS38595"
                     /old_locus_tag="FNV62_39155"
     CDS             4257..4664
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127343.1"
                     /locus_tag="FNV62_RS38595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39155"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_143603276.1"
                     /transl_table=11
                     /translation="MANGSGVPEKVAWILVRDDRVLVTRSHGRDRFYFPGGHREPGESD
                     GETLVREIDEELQAAIDPGSMVHFGTFEIGEGHPDHGPFRMICYTADHRGELTPSREIA
                     EKAWFRYADRDRVSAVDEMAFDALYEAGRLS"
     gene            complement(5001..5210)
                     /locus_tag="FNV62_RS38600"
                     /old_locus_tag="FNV62_39160"
     CDS             complement(5001..5210)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009311933.1"
                     /locus_tag="FNV62_RS38600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39160"
                     /product="hypothetical protein"
                     /protein_id="WP_060897029.1"
                     /sec_met_domain="strepbact (E-value: 3.1e-14, bitscore:
                     52.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSAPQVQTLEISDAELDTVSGGLSPQVGMAAGPTAISSSDLVGQ
                     FGAVKDEVLDTVGQYHQVGLTVSF"
     misc_feature    5225..5240
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.09"
                     /tool="antismash"
     misc_feature    complement(5348..5361)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            5732..6970
                     /locus_tag="FNV62_RS38605"
                     /old_locus_tag="FNV62_39165"
     CDS             5732..6970
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431891.1"
                     /locus_tag="FNV62_RS38605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39165"
                     /product="MFS transporter"
                     /protein_id="WP_225900512.1"
                     /transl_table=11
                     /translation="MRRDRDFGVFWVAQTLSVLGDSFALIALPLLVLHATGSVARMGLL
                     TAVGGAASVVAGVFAGVVVDRVDRRKLLVTCDLVRMALYAVIPLVWVFGPRIWLLYVVL
                     PLCEAVGMLFSVAYVTVIRNLVGVERITEANGRLNATAAAAGVAGPVCAGLVAAWLGPA
                     AAVGVDAASFGVSAACVGFVRFKGTTRPAPGPVAGTGVVRRLWTDLLAGVSFLVRHPVL
                     RVLTVLLSFFSFLTLGLNDLLIYHLKHDLGRDDAAVGTVFAVGALGTIAGALLVARVRR
                     RLGFGPTWIGSVAVCGCALAGLGWARSVPAVAALTAVFLGFGSVAGTCSMSLRQEVTPE
                     HLLGRVTSAFWTLHYSAAPAGAAVLTWAAGRHGTAAVGVVAGACCVLVAVLALLTPVRR
                     PRTDGAGAPVVSR"
     gene            complement(6960..7760)
                     /locus_tag="FNV62_RS38610"
                     /old_locus_tag="FNV62_39170"
     CDS             complement(6960..7760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118937.1"
                     /locus_tag="FNV62_RS38610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39170"
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_143652254.1"
                     /transl_table=11
                     /translation="MKSLRIVWRITRLNFRAQLEYRSEFLLMIAIGAIWQVSVIVFATV
                     LLTRFAGMGGWASQDVLLIAATRMLAHGLFVLFLGRVHGLARHIQEGVIDTYLVRPMPV
                     HRQLQLSVFPTNAIGDLTVATGLMVGALTRSQLDWNAARISYLVVCVLGGMLLEAALFT
                     AVACASLRFPAADYWGRWLEELLGTFGSYPLNVLPRAVGGFLTFGLPLAFVAYFPAAVL
                     TGHGGDSGVPYWLAAASPLVGLLAYLGARLLWRWSLGHYSGVNG"
     gene            complement(7823..8557)
                     /locus_tag="FNV62_RS38615"
                     /old_locus_tag="FNV62_39175"
     CDS             complement(7823..8557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485996.1"
                     /locus_tag="FNV62_RS38615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39175"
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_079090233.1"
                     /transl_table=11
                     /translation="MTAALLRLVVQVVLVASLWRGLYATTGTTAGLTRDQAVTYAVLAV
                     LATRIRALDQYSGRDTVQQHMHFGTIVYWYLRPLPPQRYYALRALGEQLYGFLWASTGY
                     AVCLAVGFVQPPGSAAVAAVFGLSVLLGQWVLYYVMLVIDQLCFWTLRNGAAILILVFA
                     QNLLSGVYAPLWFFPDWFITLSRFLPFQATLSVPLSLYVGRIPVSQAAPQLALQAAWVV
                     ALALFTRLLWRRAARRVISQGG"
     gene            complement(8629..9624)
                     /locus_tag="FNV62_RS38620"
                     /old_locus_tag="FNV62_39180"
     CDS             complement(8629..9624)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125381.1"
                     /locus_tag="FNV62_RS38620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_39180"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_097286714.1"
                     /transl_table=11
                     /translation="MSGSIQVRGLSRTFHTTVRRPGFSGALKSLVKPERVAKEAVCDVT
                     FEVAPGELLALLGPNGAGKSTTIKMLTGILTPTSGEARVAGVVPYRERERNARNIGAVF
                     GQRTQLWWDLPVRESFAILRDIYGVPEREHRVRLGEFDELLALSSFWDTRVRHLSLGQR
                     VRCDLAAALLHDPPVVFLDEPTIGMDVVVKEQVRGFLKHQVEERGRTVLLTTHDMTEVE
                     RLAERVVLINHGRLVLDGTLDEIRRRFGSTWQVRATLADPQAAIAPPPGIALLRREGPQ
                     VVFGPDGPGAPTVHQALKQVVERYEVTDLAIDEADLEDVMRAAYVQAEAA"
ORIGIN
        1 tgccgtacgc cgatgatcaa tgccgggttc gaccttgctg tccctcgccg tagagacaag
       61 gatggcgtcc cgccacgtgg tgtaggggat caagacaccg gaatccgcag gccaggggcg
      121 ccgacgatgc ccgatcggat gtccaactcg ccttaccggg acgcttcgtg ggctgcagtc
      181 tccgcagaga tcgccacggg tctcgaaccg gaacgcgtag cgcttgatcc cctacaccac
      241 gtcctgggac acgaccgaga caagagcgct tgggaggcac ttgaggccac gctgcgtgcc
      301 ggcctcacct tccactcgtg cggttgtggc ggccccggct accgaccgcg ctcgaccgca
      361 gaggtccggg agcgacgccg ggcggcgagg cagctggggc tgctggagcc ggcgatgctg
      421 gagcgctacg acccttggga agaactagcg cggtgaggtg ggcgcgtaca gcagcgaaat
      481 acagcaaccc agcaaccagc agcgcccaac ggtggccctc atagccatcg cggtagcccg
      541 tatgaccttc aatgaccgac ctctgtagag ctatggatca gaaggttgca ccagatgggg
      601 acggtctggc ctcgtgccag gccgtctcag tttccctatc attcagcgac gttcaccgtc
      661 gttcaggcgg gtccatcagc agaagacgtc acggtgttca ctcgcccatg aacgcaggtg
      721 aacgcctttg cacacagccc accgccccac caacacgctt ggaaagcgag cacaccggag
      781 tcaaaagccc ttgaacgcgc ggtgtcagca gatcaggatg cagacgtgac cttcatggtg
      841 gttcgcggaa gcgccgagtg cgggccgtac cgctgtccct gttgcggctt catcaccctg
      901 gccgagcgtg gagtcttcga gatctgcacc gtctgccgct gggaggacga cggccaggac
      961 gagcacgacg cgagcgaggt gcacggcggc cccaatcgcg gcctcagtct gcgccaagct
     1021 cgccggaact tccacgtgtt cggcgcgtgc gacgagcgca gcgcccagtt cgctcgcgct
     1081 ccgctgccag aagagcatcc tgacagcggc acaccctacg gaatcggcac cctctactcg
     1141 gggtcctgac tccccgagct tgagccgcac cgcatgcgca ccagatcgag tggggaacag
     1201 cgggggaacc acggtgaaag ccgccgagcc gacgaggccg gccaccaacc gttcattcag
     1261 gtcagcgccc taccaggcct caaagggacg cagcttccca agctgaggtc cacagcggtc
     1321 tctgctgtgc tcgcggccgc cgcagtgttg tgcactccgg ggtaggtggt gagccgcagg
     1381 ccgctgatcg agctacgtgc cgggccagcc aatagtcaca tcgatggcac gagcctccca
     1441 gcccgggttg tccaccgcca cacggacgtt ccaggctccc cggtccccca ccaggcgtac
     1501 gaagcgggtg agcccctcga cgtcgccgac agccaggcgc ccatccggca ggaggagttg
     1561 gccgtcaaac acggtcataa atctcggatc ggcccccgcg ggatcgtcgg agttccggaa
     1621 gacgcgcact cggatgagat ccagctgagg ccgtacgcgg actgcgacat gggtgtcgca
     1681 gcttgccgca tccgcgtctc ccaggtcgag ggaggtcgga acccagtcag tcgcgcccag
     1741 gtggagcact gggtgattga catacacctc aacgcctgcg atctgcacct gtgttctcca
     1801 ctcgccacga tcgatggtcg tgccaaaacc tagccagcca ggtgagccag agccaacgcg
     1861 gggcgggatc gcacccacta aggctgtccg cctgacatca ccggctgaca tcaacggcgc
     1921 cgaacagtgg cggacaggga cgaccacggt cggaacgaat ggcaaaccca gaaccgcgtt
     1981 ccaggaggct atggcacaga gtgatcgaac ttacaaggcg gctgtctctc tcccccaacg
     2041 cccgagcgcc ctcccgggcc gtaccggggc cgtgggaggg cgctcgatgg tgaccaacgt
     2101 cgaccactgc cgatagctca gcagcaggtc agagcgttga tcggttagcc agccgcaggt
     2161 ggcggccgcc aatgatcagt tggggttgtg cagatcacgc ggcgtcgaac tgagtggcca
     2221 ggaacaccgc tgccaccgag gggcggactg cgtacgttgc acccgcgctc ccctcaggag
     2281 cctcccacca gtagaacgga agccgccgct cactgttgct gtgtcccttg ctcatcccgg
     2341 acagcacccc tgccacgcgc cgcgccggat cactctcgtt cggcccgccc agggccttat
     2401 ccaccaactc cgtgcagtgg atcctccggc cagggttgcg cagcaggtgc tggaacaccc
     2461 gccgggcctg cggcgcgagt tcggccaaga acatcgcggc gcgctccaag tcctccggac
     2521 cccattccga ggctccatag tgccccgctt caccagagtg cttagcccat cgtggatcag
     2581 cctcagtcag atacgccgtc atgcccgccc ccaacagttc gcccctagcg tgtgtgtcgt
     2641 tcgcaccgta cagatccgcc aggacactgc gtgtcgaatc cgtgtcgaag ttccaccggc
     2701 aagcagctca gctgaggaag agccacaggc caagaggggg acgggacgca gccacagagc
     2761 gccctttcta ggcgctccgt cgttcggaac gtgccacagc cgtgccacat cgtgcgggca
     2821 accacagtca acgacggttc gccgcagttg cgatgccccg ttcagctggg ctactgctgc
     2881 agccagggtg acctgggcga ctccgccgcc gaccacggct gcccttacaa agcagaggtc
     2941 gcgtgtgtga agcggccagg gtcgatggtc ttccgatgtc agaccgcggt gagatcgtgt
     3001 cgcgcatgga cgcgatcttc gacctccccg taacgagtgc ccccgagcag gttgtcatcg
     3061 ctcgcttccg gctgagtggc gaagagttcg gcgagcgtgc tgagcgcgca gtgatcttcc
     3121 gcgcggaacg cgctatggcg gtcgcggtcg gggaagcggg agttggggag gtggagggga
     3181 acgagttcgg tggcggcgag gccatggtgt acgcgtacgg gcctgacgcc ggagtcctct
     3241 tcaaggtcat ggaaccgata ctgcgtggac ttccgttcag gccggcgcat gtcgtcctgc
     3301 gtcacggggc tgcggagaca cagtttcatg tggatctgtg aaggagcggg cacagcagcg
     3361 cagtgccgca accccaacaa ccaagccaga ccgacagcgc cctcagagcc tcgaagcggc
     3421 cggtatggcc gtcgccggcc gatctgcatt gagccaccgg tcagaagctc ccgccatcag
     3481 gagacagctc aacgctcacc cgggccatcc gtgaggcacc gagagtttca gggccccgga
     3541 gttcagcgca gaggcccccg ctcgtccaca cggcgtgtcg gcacgctcag gaacacatcg
     3601 ggcgctgcgg ggccataaag gatgttgaat gtctccagtt gataggacca ggccccgtca
     3661 caactgccga cgaaccggtg gttgatctgc cattgcagcc actggccggg agccaggcga
     3721 acggcgggcg ggcgtcgatt gcgtcgaggc atgccaaaca tggtcacctc tggcggatcc
     3781 acgcgcagca agccgtcgac ttcgcggagg atcatgccgg gcgccgacag atcccgcacc
     3841 tgcatacgag gctcgaagga atcggcctct cccatagcga cctcatggag ggcagaactc
     3901 aagcccggag gcagcaagaa gaccgttggg gcagcgttcc tccgggcagc ttcagagccg
     3961 ccgcgcgact tcttcgtcca cgacgtgcgc acccgctgaa cgacagcatc catggggctc
     4021 gatcatcaag catgacgccg taccgcggcc acagagttgg ataccgtgcc agacccgtgc
     4081 cagatcgttg cggggaatca cggggaacac cgggcaccaa gtcggcggtc agctggacgc
     4141 cggcaccacg ccaccgcagg tcgaccgggc aacccgtccc ggaacacctc agcttcccaa
     4201 gctcagtgtg cggacggtgc tgacgcaaac gatgccctcc gatacggtcc cgaggcatgg
     4261 cgaatggcag cggtgtgccg gagaaggtgg cgtggatcct ggttcgggac gaccgggtgt
     4321 tggtgacgcg tagtcacggc agagatcgct tctacttccc gggcggtcat cgtgagccgg
     4381 gcgagtccga cggcgagacc ctggtgcggg agatcgacga ggaactgcag gcggcgatcg
     4441 accccggttc catggtgcac ttcggcacgt tcgagatcgg cgagggccat ccggatcacg
     4501 gccctttccg aatgatctgt tacaccgccg atcaccgcgg tgagctgacc ccgtcgaggg
     4561 agatcgccga gaaggcgtgg ttccgctacg ccgatcggga ccgagtctcg gccgtcgacg
     4621 agatggcctt cgacgcgctt tacgaggccg ggcggctttc ctgatcccgt gaccgctgta
     4681 cagcagtgga gtacagcgag caccacgacc gcagccgagt gatatcgctc gtaccaagac
     4741 ggcgcagcgc ctgccaccag cgcagccaac gcttcgagcg agaccttgcc gccgggtggc
     4801 aaccggacgt acgtcgctcg ggaaagccca gctcaccaag atccccgaca agacccaggg
     4861 aaagaagcag cagcccccga cgatcaagcc ccctaccggc gcggacccgc gggcaggggg
     4921 cttgtcgctg tggacgccga tcggcggtca ggctgctggt gtcagcgatc ccgcgatgag
     4981 gaagtcccgc gatcggacga tcagaaggag acggtcaggc cgacctggtg gtactggccg
     5041 acggtgtcca ggacctcgtc cttgaccgcg ccgaactgac ccacgaggtc cgagctactg
     5101 atcgccgtgg ggccggcggc catgccgacc tgcgggctca gaccgccgga gacggtgtcg
     5161 agctcggcgt cagagatttc gagggtctga acctggggag cggagttcat gatgaaactg
     5221 cccttcgtat ggatgttcca caagggggga gcggccaggc tggggatagc cggtgggccg
     5281 cgaccgcagg cgcgcgccat ccgtttccgg acgtcttggc gcgatgccgt cggcgcgaag
     5341 gatcaaatca cggagggtgc ccggcatcca gtcgttcgcc gctcccagca cggcagttgg
     5401 aacacttggc tactcatcca tgcacgcatg cacacgaatt cagggcagct tctctacatg
     5461 tagcccggca caggaatccg acagctattg ccacggcggc tccgaccagg acaactccgt
     5521 accaatagaa cccacccgtg ccgcagttgc gcattcgctg tgcagattca gtcacgtgtg
     5581 catccgtgca cccgtcccgt ctaggctggt cgacgagtgg atcggggtga cgggggccga
     5641 cacggtggcg tacagggcgc ggcgtgggag agagcccagg ccttcggagc gggcggcaga
     5701 aggcactgtt gacgaaggca ccccacaacc gttgcggcgg gaccgtgact tcggtgtctt
     5761 ctgggtcgct cagacccttt cggtcctcgg ggactccttc gcactgatcg ccctgccgct
     5821 gctcgtgctg cacgcgaccg gatccgtcgc gcggatgggc ctgttgacgg ccgtcggcgg
     5881 ggcggcctcg gtcgtggccg gggtcttcgc cggggtcgtc gtcgaccggg tggaccgtag
     5941 gaagctgctg gtgacctgcg atctggtccg tatggcgctg tacgcggtga ttccgctggt
     6001 ctgggtcttc ggaccgcgga tctggctgct ctacgtggtc ctgccgctgt gcgaggccgt
     6061 cggcatgctg ttctccgtcg cctacgtcac cgtcatccgc aacctcgtcg gcgtcgagcg
     6121 gatcacggag gccaacggca ggctgaacgc gaccgcggcg gcggccgggg tggccggtcc
     6181 ggtgtgcgcg gggctggtgg cggcgtggct cgggccggcc gccgccgtcg gcgtggacgc
     6241 ggcgagcttc ggcgtgtcgg cagcctgcgt cggcttcgta cggttcaagg gcaccacacg
     6301 ccccgcaccg ggacccgtgg ccggaacggg agtggtccgg cggctgtgga cggatctgct
     6361 cgccggggtg tccttcctgg tccggcatcc ggtgctgcgc gtgctgaccg tcctgctgtc
     6421 cttcttcagt ttcctgacac tcggcctgaa cgacctgctg atctaccacc tcaagcacga
     6481 tctcggccgc gacgacgccg cggtcggcac cgtgttcgcg gtcggcgcgc tcggcacgat
     6541 cgccggggcg ctcctggtgg cccgggtgcg ccgacgcctg ggcttcggcc cgacctggat
     6601 cggttcggtg gcggtgtgcg gatgcgcgct ggcggggctg ggctgggccc gcagcgtgcc
     6661 ggccgtcgcc gccctgaccg cggtcttcct gggcttcggg agcgtggcgg gcacgtgctc
     6721 catgtcgctg cggcaggagg tgactccgga gcatctgctc ggacgggtca cctcggcgtt
     6781 ctggacgttg cactactcgg cggccccggc cggcgcggcc gtcctcacct gggccgcggg
     6841 gcgccacggc acggcggcgg tgggcgtggt cgcgggcgcc tgctgcgtgc tcgtcgccgt
     6901 actggcgctg ctcaccccgg tgcgccggcc ccgtacagat ggcgccggcg caccggtcgt
     6961 cagccgttga ccccggagta gtggccgagg ctccagcgcc acagcagccg cgcgcccaga
     7021 taggcgagca gccccaccag cggtgaggcc gccgccagcc agtacggcac ccccgagtcg
     7081 ccgccgtgtc cggtcagcac ggcggccggg aagtaggcga cgaaggccag cggcagcccg
     7141 aaggtgagga aaccgccgac cgcgcgcggc agcacgttga gcggatagct gccgaacgtg
     7201 ccgagcagct cctccagcca gcgcccccag tagtcggcgg ccgggaaacg cagcgaggcg
     7261 caggccaccg ccgtgaacag ggccgcctcc aggagcatcc cgcccagcac acagacgacg
     7321 aggtacgaga tccgggccgc gttccagtcc agctggctgc gggtcagcgc gcccaccatc
     7381 agcccggtcg ccaccgtcag gtcgccgatc gcgttcgtgg ggaagacgga gagctggagc
     7441 tgccggtgga ccggcatcgg gcggaccaga tacgtgtcga tcacaccctc ctggatgtgc
     7501 cgggccagtc cgtgcacccg gcccaggaag agcacgaaca gaccgtgcgc cagcatccgc
     7561 gtcgccgcga tcagcagcac gtcctggctc gcccagccgc ccatcccggc gaaccgggtg
     7621 agcagcaccg tcgcgaacac gatcaccgac acctgccaga tcgcgccgat cgcgatcatc
     7681 agcaggaact cggagcggta ctccagctgc gcgcggaagt tgagacgcgt gatgcgccac
     7741 acgatccgca gggatttcag tgatgtgctg agcttgtccg tcgtgttcgg cccgtacgtc
     7801 ctgttcggtc tgtccgtcat gctcagcctc cctgcgagat cacgcgccgg gcggcccggc
     7861 gccacagcag ccgggtgaac agggcgaggg ccaccaccca cgcggcctgc agggcgagtt
     7921 ggggcgccgc ctgcgacacc gggatccggc cgacgtacag cgacagcggc acactcagcg
     7981 tcgcctggaa agggaggaag cggctgagcg tgatgaacca gtcggggaag aaccacagcg
     8041 gcgcgtacac cccggacagc aggttctgcg cgaagaccag gatcaggatc gcggcgccgt
     8101 tgcggagcgt ccagaagcac agctggtcga tcaccagcat cacgtagtac aggacccact
     8161 ggccgagcag cacgctcagc ccgaacaccg ccgccacggc ggccgacccg ggcggctgga
     8221 cgaacccgac ggccagacac accgcgtatc cggtcgacgc ccagaggaat ccgtagagtt
     8281 gctcgccgag cgcccgcaac gcgtagtagc gctgcggggg cagcgggcgc agataccagt
     8341 acacgatggt gccgaagtgc atgtgctgct ggacggtgtc ccggcccgag tactggtcca
     8401 acgccctgat ccgggtggcc agtaccgcga gcacggcgta ggtgacggcc tggtcgcggg
     8461 tgaggcccgc ggtggtgccg gtcgtcgcgt acaggccgcg ccacagcgag gccaccagca
     8521 ccacctgcac gacgaggcgc agcagcgcgg cggtcatccg gggcggggtg tgcagctcgc
     8581 cgagcggggt gacccgggcg gcccgccagc cgccggggac ggtcgcgctc acgcggcctc
     8641 cgcctggacg tacgccgccc gcatcacgtc ctccaggtcc gcctcgtcga tcgcgaggtc
     8701 ggtcacctcg taccgctcga cgacctgctt gagcgcctgg tggaccgtcg gggcgccggg
     8761 cccgtccggt ccgaacacca cctgggggcc ctcgcggcgc agcagtgcga tgcccggcgg
     8821 tggggcgatc gccgcctgtg gatcggcgag cgtggcccgc acctgccagg tcgagccgaa
     8881 cctgcgcctg atctcgtcca gggtgccgtc gaggacgagc cgcccgtggt tgatgagcac
     8941 gacccgctcg gcgagccgct cgacctccgt catgtcgtgc gtggtcagca gcacggtccg
     9001 gccgcgctcc tccacctggt gcttgaggaa gccgcgtacc tgttccttga ccaccacgtc
     9061 catgccgatg gtgggttcgt cgaggaacac cacgggcggg tcgtgcagca gcgcggcggc
     9121 gaggtcgcag cgcacccgct ggccgaggga gagatggcgc acgcgggtgt cccagaagga
     9181 ggagagggcg agcagctcgt cgaactcgcc gaggcggacg cggtgttcac gctccggcac
     9241 cccgtagatg tcccgcagga tcgcgaagga ctctcgcacc ggcaggtccc accacagctg
     9301 ggtgcgctgt ccgaacaccg ccccgatgtt gcgtgcgttg cgctcgcgct cccggtacgg
     9361 gacgacgccc gcgacgcgcg cctcgccgga ggtcggggtg aggatgccgg tgagcatctt
     9421 gatggtggtg gacttgccgg cgccgttcgg gccgagcagc gcgagcagtt cgccgggcgc
     9481 cacctcgaag gtgacgtcgc agacggcctc cttcgcgacc cgctcgggct tgacgaggga
     9541 cttgagcgcg cccgagaagc ccgggcggcg cacggtggtg tgaaaggtcc gggacagccc
     9601 ccggacctgg atgctgccgc tcatgcggac gccttccggg tcagtgcgat cagccacagg
     9661 gtggccacga gcgaggccgc ggacagggcg gtcagcagcc aggggacggc gtggatcccc
     9721 gacgcctcga tgcccacgcc gagcagcgga ggagccgcca ccccgccgat catggacgcc
     9781 gcgatcaccc aggccccggc cctcttcgcc tgcgggaggg ccctgttgag ccacggcagc
     9841 ccggtcggga agacgggcgc gatgaacaga cccacaccgg cgtacgccac cggcgccgcc
     9901 ccggggatca gcgccagcag caggcacgcg gtcatcccgg ccgcgcagac cgcgaggatg
     9961 cgctcgggcg cgtaccgcag ggcgaccggg acgacgagga agcggcccgc ggtcatcatc
    10021 agccagtaga cggaggtggc ggaggcggcg accgtcgcgc tgtaaccgac ggtctccagg
    10081 tgggtgggtt cccagccgcc gacgcccgcc tcgacaccga cgttcaggat gtagaggagc
    10141 aggaagccca ccaggacgcg ggagagcagg ccaccggaag cggcgggccg ctcggccggg
    10201 gagacgggcg
//
