LOCUS       NZ_CP041610            22569 bp    DNA     linear   CON 14-NOV-2023
DEFINITION  Streptomyces sp. RLB3-17 chromosome, complete genome.
ACCESSION   NZ_CP041610
VERSION     NZ_CP041610.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RLB3-17
  ORGANISM  Streptomyces sp. RLB3-17
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66.0x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/14/2023 04:19:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,027
            CDSs (total)                      :: 10,924
            Genes (coding)                    :: 10,421
            CDSs (with protein)               :: 10,421
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 503
            CDSs (without protein)            :: 503
            Pseudo Genes (ambiguous residues) :: 0 of 503
            Pseudo Genes (frameshifted)       :: 178 of 503
            Pseudo Genes (incomplete)         :: 409 of 503
            Pseudo Genes (internal stop)      :: 52 of 503
            Pseudo Genes (multiple problems)  :: 128 of 503
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5141847
            Orig. end                         :: 5164416
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041610.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041610.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22569
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="20"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22569
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22569
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12569](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12569
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    15..32
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    319..337
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.2"
                     /tool="antismash"
     gene            540..992
                     /locus_tag="FNV62_RS23330"
                     /old_locus_tag="FNV62_23680"
     CDS             540..992
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485793.1"
                     /locus_tag="FNV62_RS23330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23680"
                     /product="DUF485 domain-containing protein"
                     /protein_id="WP_097285125.1"
                     /transl_table=11
                     /translation="MPDPFPYPEYQPRRSGAPYRPAPHFASSDVIYAWQQQEFDSGATS
                     PHTGLGHHSDLRVLRRAYRTQRRVATFTALGYFTLFLVLSAFAPSLMTGTVSGGLSTGL
                     LLGLLQVPVTCLAVGLYEHAARRRVDPIADRIRKHAELDVKRGVAR"
     gene            1019..2593
                     /locus_tag="FNV62_RS23335"
                     /old_locus_tag="FNV62_23685"
     CDS             1019..2593
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064625.1"
                     /locus_tag="FNV62_RS23335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23685"
                     /product="cation acetate symporter"
                     /protein_id="WP_225900345.1"
                     /transl_table=11
                     /translation="MSLVAFTAVATIILLLCVMTGPDGDDLDEFYTGYGSLSPMRNGLA
                     IAGDYISAATVLSTGGVIALDGYDGVVLALSIALSLMLLMFLLAEPLRNAGRFTMGDVL
                     ARRMPGRKVRIAACGATIAALLPMMLIQLAGTGDLLAFILGFSSDSLKTGCIVGIGALM
                     ITYAVIGGMKGTALIQVLKIVMLFGSGAVVAALILRQFDWDLGKLFSAAAAHSGVGPAF
                     LHSGLQFAGGPSPRLDMISSELTVILGGACLPHVTMRMYTATSARQVRRSMSWAVSCVA
                     LFMLICTVVSIGATALIGRTTIAGADPTGRTAYLLSSRAALGTSVSTSETFLFTMVTTA
                     LFLTLLASVASMILACANTLAHDLLARRDTTPRREMTIARVSALAVGAPTILLATLVQH
                     HNLQPLALLSASIGASALAPALVYSLFWRRYTRTGLLWTLIGGTLATLVLMTGTNLVSG
                     SPFSAFPHSDFNWFPFTTTGLVSIPLGFAFGWTGTKISGRQKAEEQRQQYEAVEAWILA
                     GAARRGS"
     gene            complement(2874..3662)
                     /locus_tag="FNV62_RS23340"
                     /old_locus_tag="FNV62_23690"
     CDS             complement(2874..3662)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS23340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV62_23690"
                     /product="hypothetical protein"
                     /protein_id="WP_186003099.1"
                     /transl_table=11
                     /translation="MTSLPAVVLVVGWLVLALLVAAAARVGVRVLVPVEERDRVPQIAT
                     PLMPTLGAAFAIFAALTLASEAGYLRAAEGLVSDEAAAASRLAWAATSPRVHSEPIHAA
                     LLDYLQTTRAREWEAAAAASGDDPATAHAIARLERSVRAEAARPEVGTPTGTELVVSMD
                     GVTSSRRARIAAASRDVPALYVVTLVVSGLALIVNSGALVFRSSLRTSLLIVGVASVVG
                     LSLALLFALSAPWSGPFIVSGQPLDAIIEDLKSGFFAGGS"
     misc_feature    complement(3609..3611)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3926..3939
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.99"
                     /tool="antismash"
     gene            3966..4430
                     /locus_tag="FNV62_RS23345"
                     /old_locus_tag="FNV62_23695"
     CDS             3966..4430
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950289.1"
                     /locus_tag="FNV62_RS23345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23695"
                     /product="hypothetical protein"
                     /protein_id="WP_143627001.1"
                     /transl_table=11
                     /translation="METIIASAIAVLGTLLGSGITLAFQQRTTDRSHQFARREKLRQER
                     LDAYSIYAGALINYRRCLVHLWVCEHEQPPPEDPDSVRIRAYDLRSSAQEALFRVQMLT
                     DDATLGQTAEAVLADITALTKTETRSQLDQRRVQTRDDISRLVRAAKQHL"
     gene            complement(4799..5176)
                     /locus_tag="FNV62_RS23350"
                     /old_locus_tag="FNV62_23700"
     CDS             complement(4799..5176)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893118.1"
                     /locus_tag="FNV62_RS23350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23700"
                     /product="DUF5958 family protein"
                     /protein_id="WP_263986621.1"
                     /transl_table=11
                     /translation="MILNELAQGLRPVADGVEWFEGLSDDDRRKALHTLALFCGEARAG
                     EDDVAESIARSGIRPTHTPAVMLTKWRFGMDRLPASELTKSFRLLVALFGIADTRRRTL
                     HCVGGCGHEWHNLSDQPQDPT"
     tRNA            5429..5570
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FNV62_RS23355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-OTHER"
     gene            5429..5570
                     /locus_tag="FNV62_RS23355"
     gene            complement(5868..6560)
                     /locus_tag="FNV62_RS23360"
                     /old_locus_tag="FNV62_23705"
     CDS             complement(5868..6560)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.3"
                     /locus_tag="FNV62_RS23360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23705"
                     /product="response regulator transcription factor"
                     /protein_id="WP_054228351.1"
                     /transl_table=11
                     /translation="MRINLFILSEDPVSLAGLEAIVEQDDSVNLIGTAVDESHGLRCLE
                     NNPLRPDVVIIAEPPSKRAICRNVAWIVSLYRQEKSRPQIVVVSQNDYDDVIVSALRLG
                     VNGYLARIASPEELFQALHIVARGGAAFSPTIAARFSRFFATIQRLPEPPEFSQLTSRE
                     AEILELLADGMNNRQIARRLFLAEKTVRNYVSRIFTKLEVHDRAAAVLRARDAGFGDQA
                     DAVLPQHA"
     misc_feature    complement(6546..6561)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    6556..6569
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(6595..6608)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
     gene            6711..7844
                     /locus_tag="FNV62_RS23365"
                     /old_locus_tag="FNV62_23710"
     CDS             6711..7844
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958865.1"
                     /locus_tag="FNV62_RS23365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23710"
                     /product="sensor histidine kinase"
                     /protein_id="WP_143601957.1"
                     /transl_table=11
                     /translation="MGDVSRRRLILLDGAAALGFALLPQLTLVRPDSGGAPGGLAVSLL
                     SLATALPLAVRRLWPVPVFAIVLTASCVALAAGLGPAVFLSAAYALYLVATTRRRQLGR
                     SAVIVGGASTAGAALLTVTGGQHYTGGTLAVQLLFGLLVLGATWAAGTAVRERRESLRR
                     TIVQATEQAKVEERMRIARDIHDVVTHSVGLIAIKAGVANHVIATHPEEAGEALTVIED
                     ISRRALRDMRATLKVLRREDDAQQQDLQPVPGLSDLPSLVRTAEAAGVSVDLRSDCVEE
                     PPDGVALTAFRIVQEALTNVVKHAAPTRCLVSVTAQDGVLTIGVTDDGPGPGHRPTVPG
                     GAMGLVGMRERAVAHGGTLTAGPRPGAGFRILATLPY"
     gene            7991..8938
                     /locus_tag="FNV62_RS23370"
                     /old_locus_tag="FNV62_23715"
     CDS             7991..8938
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173620.1"
                     /locus_tag="FNV62_RS23370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23715"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_097285130.1"
                     /transl_table=11
                     /translation="MIDVQNLTKRYGPATVVDGLTFTVRPGAVTGFLGPNGAGKSTTLR
                     MMLGLTRPDTGTARIDGHAYGDLAHPLRRIGALLETSAPHRGLTARDHLLWLAQSNRIA
                     RGRVAEVLEAVGLADAARRRTGTFSLGMGQRLGLAAALLGDPPVLVLDEPVNGLDTEGI
                     RWLRDLLRSMAAEGRTVLISSHLMTEMALVADHLVVISRGRLLADTGMSDFIERHGRSY
                     VRVRTAEPDRLGRELEGRGATVSRVPGGGLDVVGMAAADVSRIAAAGGFPLDELATHAG
                     SLEETFLDVIGEEGTRAGADGARALGEEGRNTHV"
     gene            8931..9683
                     /locus_tag="FNV62_RS23375"
                     /old_locus_tag="FNV62_23720"
     CDS             8931..9683
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.3"
                     /locus_tag="FNV62_RS23375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23720"
                     /product="ABC transporter permease"
                     /protein_id="WP_060900510.1"
                     /transl_table=11
                     /translation="MSETLAAVRAETTKLRGIRGTRISLLLFAAVSVLIAALDGWSAKN
                     ALESDNPSLRSDFTPEQAGLDGILYGQLALIVFGVLVVTSEYTSGMIRVSLLAVPRRGR
                     LYAAKTVVTALAAVAVSVPVTVLGYLVTQAALGSHGSSLGASGVPRALAGAVVYLTLMC
                     LFAAGIAAIARNAVVPLAVLLPMVLAGTHILSLIGATKEMARYFPDQAGNELLTVRSPH
                     TAFGFTVLLAWTVAALGWGWVRQRRWDS"
     gene            9799..9927
                     /locus_tag="FNV62_RS23380"
                     /old_locus_tag="FNV62_23725"
     CDS             9799..9927
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_103079660.1"
                     /locus_tag="FNV62_RS23380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23725"
                     /product="aborycin family tricyclic lasso peptide"
                     /protein_id="WP_103079660.1"
                     /transl_table=11
                     /translation="MSAIYEPPMLQEVGDFEELTKCLGVGSCNDFAGCGYAIVCFW"
     gene            10001..11842
                     /locus_tag="FNV62_RS23385"
                     /old_locus_tag="FNV62_23730"
     CDS             10001..11842
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_067372303.1"
                     /locus_tag="FNV62_RS23385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23730"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_143601959.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.4e-37, bitscore:
                     128.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFVVLPDCPAGAAAAGRLRATRRVDHASGRPWIVGDWPEAEAVV
                     VQAGPRRMVVLGHTRLDETAAAAALGRLRSLHDVDSIASRLPGAVHLAVSLDGRTRVQG
                     SAVGVRQIFTAVVDGVTVAASGVEPLLRLTGAGLDETVLAARLLAPGGPPWPLAQRPVR
                     RGVEALTTGHWLELDTDGRARQTRWWELPEPSLTLAQGAAAVRSALDDAITSRVAAGGT
                     LSADLSGGLDSTSLCFLAHAAGADLVTYHVTPIDSANADTMWAHRAAECLPAARHHTLS
                     ADRAENLFDVGYTTDLVGAAPEGPSTWASGLAHIQDLAKRATAEGATLHLTGFGGDELF
                     GRMPACAWSLARATPVGGLRLVNRYRLANRWPWRATVRSLLDRSTFTQNLGRVAARIDA
                     PPPPVDEPDFGWVFAPRMPTWATPDAVAAVRALLTDAATEGPGPLDADRARHQALASLV
                     FEGTTVRQVNSALGDTGITWDAPFLDDRVVEAALATRIDQRLLGGRFKPLLTSAARGLV
                     PADILGRRDKGEFSAEAFRGLARNRARILELCEDSQLARLGLIDPAAFRSAVLNPGPMS
                     HHLQPIDTTVACESWLRTHPETYPMPPARNTPTGEHR"
     aSDomain        11839..12012
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FNV62_RS23390_Lasso_Fused_RRE.1"
                     /evalue="1.10E-10"
                     /identifier="RREFam003.1"
                     /label="FNV62_RS23390"
                     /locus_tag="FNV62_RS23390"
                     /protein_end="58"
                     /protein_start="0"
                     /score="32.4"
                     /tool="antismash"
                     /translation="MKLTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDG
                     TAPDAAAAGLCAA"
     gene            11839..12102
                     /locus_tag="FNV62_RS23390"
                     /old_locus_tag="FNV62_23735"
     CDS             11839..12102
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123202.1"
                     /locus_tag="FNV62_RS23390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23735"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_054228346.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 4.4e-08,
                     bitscore: 32.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.7e-23,
                     bitscore: 81.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5e-11, bitscore: 42.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDG
                     TAPDAAAAGLCAAAPVSDDQARQDVQALIDALSAAKLVEVAS"
     aSDomain        11845..12093
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FNV62_RS23390_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="7.00E-26"
                     /identifier="RREFam002.1"
                     /label="FNV62_RS23390"
                     /locus_tag="FNV62_RS23390"
                     /protein_end="85"
                     /protein_start="2"
                     /score="81.1"
                     /tool="antismash"
                     /translation="LTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDGTA
                     PDAAAAGLCAAAPVSDDQARQDVQALIDALSAAKLVEV"
     gene            12099..12569
                     /locus_tag="FNV62_RS23395"
                     /old_locus_tag="FNV62_23740"
     CDS             12099..12569
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123203.1"
                     /locus_tag="FNV62_RS23395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23740"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_054228345.1"
                     /sec_met_domain="PF13471 (E-value: 4.9e-24, bitscore: 83.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPAVAEQAPRLPWYRQLAPRCAAGAARLLVRLPPARLHRVLGV
                     VSKGSRPAGYAEVARARRSVVSVSTRCAGLGCLQRSVATVLLCRAHGRWADWCTGFRTE
                     PFGAHAWVEAEGRPVDEPGELSVFRTVLAVRRPDGRRSTSDRPLRPSRGSRS"
     gene            12566..13531
                     /locus_tag="FNV62_RS23400"
                     /old_locus_tag="FNV62_23745"
     CDS             12566..13531
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469534.1"
                     /locus_tag="FNV62_RS23400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23745"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_143627003.1"
                     /transl_table=11
                     /translation="MTAIRAEGLYAYYGTAPAVNGLDLTVPTGSVYGFLGPNGAGKTTT
                     INMLTTLLRPTAGRAEVAGFDVAARPAEVRRRIGIVFQESTLDLDLTAAENLRFQADLC
                     GLSRRASRDAIGSMLDLMDLSERRRVPVRQFSTGLRRRLEIARGLLAEPSVLFLDEPTT
                     GLDAQTRAAVWEHLERLRRERGITVFVTTHQLDEAEHCDRIAIIDRGKVVTEGTPADLK
                     SVIGADLVVLRTDDDQRAAAAIGDRFGLPAEPTPDGLLLRVERAAALVPRLCTELGVTV
                     REVAIAPPTLDDVFLHHTGLAIRESPTGPRTLGNLGEGLR"
     gene            13528..14397
                     /locus_tag="FNV62_RS23405"
                     /old_locus_tag="FNV62_23750"
     CDS             13528..14397
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.3"
                     /locus_tag="FNV62_RS23405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23750"
                     /product="ABC transporter permease"
                     /protein_id="WP_143605450.1"
                     /transl_table=11
                     /translation="MSRTDTAPAALGDVSTAPSPTDRSRNAARPVLLLWRREMTRLRHN
                     PVRLAMGLVTPLLFLVVLGTGLDAASSSLGKAQLNDYRAYLFPGTLVMSVQAPAIAVGI
                     SLVWDRRLGVLRQMLVAPFPRASIVFGLALGGATTGAVYGLMVLSVGGIASIRYTPMLL
                     VVLLELLLVSLMFTALGLLAAVTIRQVDTFQVVVNLSLMPLMFFSGAMFPPNGLPGWLD
                     TVVKLNPLTYGVDAVRRTLPGPSVLTSEQTRLMLGDWHPPVAAELGFLAALTAVALGLA
                     GYRFSRTS"
     gene            14418..14939
                     /locus_tag="FNV62_RS23410"
                     /old_locus_tag="FNV62_23755"
     CDS             14418..14939
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.3"
                     /locus_tag="FNV62_RS23410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23755"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_205522265.1"
                     /transl_table=11
                     /translation="MDASTTDVTTTAAVRATTGHWAGAARFVARLLLAAVLAYAGLVKI
                     GDLTEAGRTVALYRIVPADSAQLVGGVLPFVEVALALLLAAGLATRAAAAGAAVLLVAY
                     AAAIASVWARGMSIDCGCFGGGGTLSGGAARGYALDLARDLLLLGAAALLIRNPRTRYA
                     LDGWVLDPKE"
     gene            14945..15676
                     /locus_tag="FNV62_RS23415"
                     /old_locus_tag="FNV62_23760"
     CDS             14945..15676
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013488.3"
                     /locus_tag="FNV62_RS23415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23760"
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_143601965.1"
                     /transl_table=11
                     /translation="MTSTQTTDATVREMVHRRQRRRRTVVVSLVAALVVVAAALVGAGL
                     VRANNTAPGKAPSRVPAGLAADKSGVAASTGAVRVDVYLDYLCPECRRTERALTTALDS
                     LRAHGGVSVVYHPVAFLDDRSAPAGYSTQAASAAACAADAGRFERYSTVLFSKQPAEQG
                     PGLSEAQLIAAGRDAGITAASFARCVEDAPYLPWVRYVSDLAASRKVALTPTVMVEGRR
                     VDVTGSDPGGALTRAVTAARR"
     gene            15673..16995
                     /gene="mslH"
                     /locus_tag="FNV62_RS23420"
                     /old_locus_tag="FNV62_23765"
     CDS             15673..16995
                     /codon_start=1
                     /gene="mslH"
                     /inference="COORDINATES: protein motif:HMM:NF038314.1"
                     /locus_tag="FNV62_RS23420"
                     /note="Involved in the biosynthesis of MS-271 and related
                     lasso peptides; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23765"
                     /product="lasso peptide C-terminal Trp epimerase"
                     /protein_id="WP_143601966.1"
                     /transl_table=11
                     /translation="MTRLTVALSGDCMATRGAVISSDPAAGRLHELLDGADFAVTNLEV
                     VPSDGRGHPVHNAAGGGCLIADSGVLDEITAAGFTVLGCANNHAMDLGTEGVLGTVDLL
                     RSRRIPFAGIGADLTTARRPVYVDRAGGSLALLACTATFLPGQEAADPSPELPGRPGLS
                     PLRHSATLRVTAPQMDVLRTIDAETGLRARRAEARTLLGVDPALLGPDRLSLFGTRFLT
                     ADEPGFTTECDPRDLDEISRWVGEARLRADLVVVSVHSHEPGPTPETPGEFLRVFAHRM
                     IDEGADVVVGHGPHFLRGVELYRNRPIFYSLGNIVSQIELTDRVSAEDYAKVTTDRPPT
                     PGRYYDRLSGHGTRLFAPHRRYWQSLVPVLTFDDGTLVTARLHPVDLGFALPVHRRGRP
                     RLADQAEAKEILTEVARLSESYGTTVRAGVDGTAELLLDVA"
     misc_feature    17032..17048
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.09"
                     /tool="antismash"
     gene            17085..17759
                     /locus_tag="FNV62_RS23425"
                     /old_locus_tag="FNV62_23770"
     CDS             17085..17759
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123207.1"
                     /locus_tag="FNV62_RS23425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23770"
                     /product="response regulator transcription factor"
                     /protein_id="WP_054228340.1"
                     /transl_table=11
                     /translation="MAESVRVLIADDQALLRGSFRVLVDSTPGMEVVGEAGDGAMAVRL
                     ARELAPDVVLMDLRMPVLDGIAATREICSDETLTGVRVLALTMFDMDEYVYPALQAGAS
                     GFMLKDASPSDLVDGIRVIATGEGVLAPTVTRRVIANFSRRGETPRPAPRLVGLTKREH
                     EVLVQIANGLSNAEISERLVISMPTVKTHVGSLLAKLHARDRAQLVIIAYESGLAERGM
                     PT"
     misc_feature    complement(17086..17100)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    18138..18150
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.61"
                     /tool="antismash"
     misc_feature    18149..18164
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.58"
                     /tool="antismash"
     misc_feature    18280..18295
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            18283..18660
                     /locus_tag="FNV62_RS57130"
                     /old_locus_tag="FNV62_23775"
     CDS             18283..18660
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FNV62_RS57130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FNV62_23775"
                     /product="hypothetical protein"
                     /protein_id="WP_143601968.1"
                     /transl_table=11
                     /translation="MSVSRKAVRLIATCVATGALVGAAAMPALAAGGGHDRDNGRGYSH
                     SYRSDHDHGGHFGDRDRDRDRDRGWGWGLDRGHDRGWDRGHDRDRDRDRGWDRGRGWDR
                     GERHGWYSDRHRDQDRYLGHH"
     gene            18984..19868
                     /locus_tag="FNV62_RS57600"
                     /old_locus_tag="FNV62_23780"
     CDS             18984..19868
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013508.3"
                     /locus_tag="FNV62_RS57600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_23780"
                     /product="chaplin family protein"
                     /protein_id="WP_205522461.1"
                     /transl_table=11
                     /translation="MEFRTERPIPIAKPNRYITFAVDVAAVNCGQAVPPLLKFYLTGNG
                     ADIPTFTTPINPCADPNSKPYPGGNGLRAGAFAGNRAVLFNDSQLGIKMVNGQGEWFGN
                     DHAFDNIRILDATPQLDKAFSPATVDKGGTSTLTMTVTNTSELAAKNDFSFADNLPAGV
                     KVASTANASTTCGNGTVSAASGGTSVALNGGDLAAGEKSCTVTVNVTADKAGTYVNRPE
                     AITTVGLNPTDPATLTVKMKGATAVGTATGSGGLLSGNVVQVPVNMPVNACGNSVNVIG
                     LLNPAAGNVCVNG"
     misc_feature    20131..20146
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.43"
                     /tool="antismash"
     misc_feature    complement(20720..20732)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(21132..21152)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    complement(21707..21718)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 atggcgagga cgaaggtcgc gtagagcgga tctccgcgag aggcggcgag gaagtcgagc
       61 gtctcgtcca gcgtccaggg cttcaactcc ctgttgtccg tgcggggcgg ctcgaccagc
      121 ttggcgacgt ggccctggac ccagctgatc accaccgcgt tcacgcgact ccagtgactg
      181 ccgaatcccg gctgaccagc aacaacgccc cgccccaacg agccgttcca cgaccggagc
      241 agtggaaccc ggcgcccacc cgacgtgaca gccgggccgc gaccatgccc gccacccgcc
      301 tgagcagccg aaacggccca ctggatgaac cgacgggccg tcacgaaaca tcgaggccag
      361 tggcccgtga tcccccggcg ccgaacagaa gtagttgata cagccatcga tctgctgcat
      421 accaactgtt cagtttggcc agagcctggc gcaggtccat acctgctggg tagcgtgcgc
      481 ccaccccccg cttcccttcg gtcccgtatg ggtccatgag tcgcatgagg agaaacggga
      541 tgccagatcc gttcccttat cccgaatacc agccgcgccg gtcaggagcg ccgtaccgcc
      601 ccgcgcctca tttcgcctct tccgatgtca tctacgcgtg gcagcagcag gagttcgaca
      661 gtggggcgac gtcgccccac acggggctcg gtcaccacag cgatctacgt gtgttgcgcc
      721 gcgcctaccg cacccagcgg cgcgtggcga cgttcacggc actcggatac ttcacgctct
      781 ttcttgtgct gtccgcgttc gcaccgtcgt tgatgacggg cactgtctcc ggcggcctgt
      841 ccacggggct gcttctcggg ctgctccagg tacccgtcac ctgtctggcg gtcgggctgt
      901 acgagcacgc cgcgcgccgc agggtcgacc cgatcgcgga ccgcattcgc aagcacgccg
      961 agctggacgt gaagcgggga gtggctcggt gagcggtttc agcagttcca cgcaagcgat
     1021 gtctttggtg gcattcacgg cggtcgctac gatcatcctg ctgctgtgcg tgatgacagg
     1081 acctgacggt gacgacctcg acgagttcta caccgggtac gggtcgctgt cgccgatgcg
     1141 caacggcctt gccatcgctg gggattacat ttccgcggcg acggtcctgt ccacaggcgg
     1201 ggtgatcgcg ctcgacgggt acgacggcgt cgtcctggca ctgagcatcg ccctctccct
     1261 catgctgctg atgttcctgc tggccgaacc gttgcgcaac gccggccggt tcaccatggg
     1321 cgacgtgctt gcgcggcgga tgcccggccg caaggtgcgc atcgccgcgt gtggggcgac
     1381 gatcgcggcc ctgctgccga tgatgctcat ccagctcgcc ggcaccggtg atctgctggc
     1441 gttcatcctt ggcttttcca gtgactcgct gaagaccgga tgcatcgtcg ggatcggcgc
     1501 actgatgatc acttacgcgg tgatcggcgg tatgaagggc acagccctca tccaggtctt
     1561 gaagatcgtg atgctgttcg gctccggcgc ggtcgtggcc gcgctgattc tgcggcagtt
     1621 cgactgggac ctgggcaagc tgttctccgc cgcggcagcg cacagcggcg tggggccggc
     1681 cttcctgcac tccggtctcc agttcgccgg tggccccagc ccccggctcg acatgatcag
     1741 ctcggagctc accgtcatcc tcggcggcgc ctgcctgccg cacgtcacca tgcgcatgta
     1801 caccgcgacc agtgcccgtc aggtgcgccg gtcgatgtcc tgggctgtgt cgtgcgtcgc
     1861 actgttcatg ctgatctgca cggtcgtcag catcggggca acggcgctga tcgggcgcac
     1921 gacgatcgcc ggtgccgacc cgacgggcag gaccgcgtat ctgctgagct cacgggccgc
     1981 gctcggaacg agtgtttcga cgtccgaaac gttcctgttc accatggtca caacggcgct
     2041 tttcctcacc ctgctcgcat cggtcgccag catgatcctg gcctgtgcca acaccctcgc
     2101 gcacgacctg ctcgcgcgcc gtgatacgac tccccgccgc gagatgacca tcgcccgggt
     2161 ctccgccctg gcggtgggcg cccccaccat cctgctggcc accctcgtcc agcatcacaa
     2221 tctgcagccg ttggctctgc tgtcggcctc catcggtgca tccgcactcg caccggcact
     2281 ggtctacagc ctcttctggc gccgctacac ccgcacgggt ctgctgtgga ccctgatcgg
     2341 cggcacactc gccaccctcg tcctcatgac cggcaccaac ctcgtctccg gttccccctt
     2401 ctccgccttc ccgcactccg acttcaactg gttcccgttc accaccaccg gccttgtctc
     2461 catacccctg ggcttcgctt tcggctggac agggacaaag atctccgggc ggcaaaaggc
     2521 ggaggaacag cgccagcagt acgaggcggt cgaagcatgg attctggcgg gggcggcgag
     2581 acgaggaagc tgaattgtgc cgaaagcacc gcccaggcgg cctgggtacc ggccaggccg
     2641 gactgctgcg gtaccggctc cagcagtacc cgtgaacccg cgcacggaca gccgaccccg
     2701 tgcggtcggg ccagacccgt gccagaccgt acgggaaacc acggggaaca ccggggaacc
     2761 ggccgacctc gcaccgggac agctcgacaa caggtcaggg ggttgattga ttgggcggcc
     2821 gcacgtcacg ggccgccggt gatcagttgt cggctactga tcgcgcccgg cgcctacgac
     2881 ccgccggcga agaagccgga cttcaggtcc tcgatgatgg cgtcgagtgg ttgcccactg
     2941 acgatgaacg gtccgctcca gggcgcgctg agtgcgaaga gcaacgccag gctcagcccg
     3001 accacactcg caacacctac gatcagcagt gacgttcgca gactgctgcg gaagaccagt
     3061 gcgccggagt tcacgatcaa ggccagtccg ctgaccacaa gcgtgacgac gtagagcgcg
     3121 ggaacgtcgc gcgaggcggc cgcgatgcgg gcgcgacggc tactggtgac accgtccatg
     3181 gagaccacca actccgtgcc tgtcggggtt cccacctcgg gccgggccgc ctcggcgcgc
     3241 acactccgct ccaggcgtgc gatcgcgtga gcggtggcgg ggtcgtcacc ggacgccgct
     3301 gctgcagcct cccactccct ggcacgcgtg gtctgcaagt agtccagaag tgccgcatgg
     3361 atcggctccg aatggacgcg cggacttgtc gccgcccatg ccaggcggga ggccgcggcc
     3421 gcctcgtcac tcaccaaccc ctcggctgcg cgcaggtagc cggcctcgct ggccagtgtg
     3481 agtgccgcaa agatcgcgaa ggcagcgccg agggtcggca tcaggggcgt ggcgatctgc
     3541 ggcacccgat cccgttcctc gaccggtacg agcacccgga cgccgacccg cgccgcggcc
     3601 gcgaccagta aggcaagaac gagccagccc acaaccagca ccaccgccgg cagcgaggtc
     3661 aaccagttca ccacatcacc tacagcgcgt tcccgcgagc gccctgcggc ggcggcacat
     3721 cggccccgcg acctggagct cctcgtcgat cactcttaat gaacgctcca tgatcacagg
     3781 ttgaagacct ttgacgctcg cgacgcccgg cacggcatct cttttcattg gccgaacagc
     3841 cgaatacgcc cagtacgagg ccgtactgac aacgaccgcc acgcccatct cgccttccgt
     3901 ctcattcagc ctcgttcagc gctgttcggc cgagatcaaa agccgatacg tgatcagctt
     3961 gggacgtgga gaccatcatc gccagtgcca tagccgtcct cggaaccttg ctcggctcgg
     4021 gaatcacact ggcgtttcag caacgcacca ccgacagaag ccaccagttc gcccgccgtg
     4081 agaagctccg gcaagaacga ctcgacgcct actccatcta cgccggcgcg ctgatcaact
     4141 accgccgctg cctggtgcac ctgtgggtct gcgagcacga acaaccgcca cccgaagacc
     4201 ccgactccgt ccggatccgt gcctacgacc tgcgctcaag cgcacaagag gccctgttcc
     4261 gggtccagat gctcacggac gacgcgaccc tgggtcagac cgcagaggcc gtcctcgccg
     4321 acatcaccgc actgaccaag acggagacca gaagccaact cgaccagcgc cgagtacaga
     4381 cccgtgacga catcagccga ctcgtcagag cagccaagca gcatctttga ggcacccccg
     4441 gacgcagccc ttcgtacggc ctgtccagcg acggcctccc aagccgagga ctcaggcacc
     4501 gtcgctacgg tccggccggc gcggcttgct ctggtcgacc gcaccggcaa cgtggccgaa
     4561 gccagttagg gtgcggcgag atatacgcgg tgcgtcactg cgcaatggcg ggcggcttcc
     4621 accggctgac gccgttcatg taccccatgg ccgggccccg tccccgggcc gtccgaggtc
     4681 gctcgacagt ggccgaggac gaccagcgac ggccatcagg cgcgcgggac catcgcgcct
     4741 gagcagggag atctcaggcc accgagatcc ccgacaaggc ccagggcaag aagtagccct
     4801 aagttggatc ctgcggctga tctgacagat tgtgccactc gtgaccacac ccgccgacgc
     4861 agtgcagcgt ccgcctgcga gtatcggcga tgccgaaaag ggcgacgagc agccgaaatg
     4921 acttcgtgag ttcagaggcc ggaagtcggt ccatcccgaa gcgccatttc gtgagcatca
     4981 ccgcaggcgt gtgcgtgggc cgaatgccag agcgcgcgat gctctccgcc acatcgtcct
     5041 cccccgcacg agcctccccg cagaacagcg ccagcgtgtg caaggccttg cgccggtcat
     5101 cgtccgagag gccctcgaac cactcgacac cgtcagccac gggtctgagc ccttgcgcga
     5161 gttcgttcag gatcacctcg tgtgcgtaca gcacagcctc tcacccccat gtgatcaggc
     5221 cgacggtacg cccgcgggcg cccgagagca gcacagtttt aggtgttccg tgcaggacgg
     5281 tttcgtccac ttctacgacg aggaaggccg aaggggttct cgatcagggc gaaccaggta
     5341 gccatggtcc agcagctcca gcggtacggc agcttcgtac ctcaaaaccc cagcaacagc
     5401 cctggcccgg cccgataccg tccctggagg cttcgtagcg gccggtatga ccgtcgccga
     5461 cttcccgtcc gggcccgcta gatcacccga agaaaccgcg ggtcaccccc aagacgcccc
     5521 cgtctctccc acaaagcggg tgtcgcaggt tcgaatcctg tcggggcaca gagaaacacc
     5581 aggtcagagt gctcctcggc gtccatggcc tgagtgagcc tgccgggacc gaagcggaac
     5641 ttcgagggat cgtgggagga gaggcgggac agtccgacgg gcgtcgggcc gaaggtgtcg
     5701 gcggccggat ggccggggcc gtcgatgccg agcgccttgg ccgaggtcac gctgctgatc
     5761 cggtcgctgc ccggtgctgc cggttccacg gggatccggc cgccaatgaa gtcgccggca
     5821 ccgcgagcac gctgaccaga gggccgcgcg ctcgctctcc tggcgtgtca ggcgtgttgg
     5881 ggcagtacgg catcggcctg gtcgccgaaa ccggcgtcgc gtgcgcgcag tacggcggcg
     5941 gcccggtcgt gcacctccag tttggtgaag atgcgggaga cgtagttgcg tacggtcttc
     6001 tccgcgagaa agaggcgccg ggcgatctgg cggttgttca tgccgtcggc gagcagttcc
     6061 agtatctccg cctccctgct ggtcagttgg gagaactcgg gcggctcggg gagtctttgt
     6121 atggtggcga agaacctgct gaagcgagcc gcgatcgtcg ggctgaacgc ggcgcccccg
     6181 cgggccacga tgtgcagcgc ctgaaacagt tcctccgggg acgcgatccg cgcgagatac
     6241 ccgttcacgc cgaggcggag ggcggagacg atcacgtcgt cgtagtcgtt ctgcgacacc
     6301 acgacgatct gtggccgtga cttctcctgg cggtacaggg agacgatcca cgcaacgttc
     6361 ctgcagatgg cgcgttttga cggtggctca gcgatgatca ccacgtccgg ccggagcggg
     6421 ttgttctcca gacatcgaag gccgtgggat tcatcgaccg ccgtgccgat gaggttgacg
     6481 ctgtcgtcct gttcgacgat cgcttcaagt ccggccaggg acaccgggtc ctcactgagg
     6541 atgaagagat tgatccgcat agctttgcac ccccgtggta agcgttgtac gcctgcaaag
     6601 acggtgccag cctaagcaga ctaaacggac ggactacacc gacttgagcg gtcatggtcc
     6661 ggttccggcc gcgttggacg tccggctgat cagacacata ggttcgggac atgggagatg
     6721 tctcgcgccg acgcctgatc ctcctcgacg gggcggcggc cctcgggttc gccctgcttc
     6781 cgcaactgac gctggtacga cccgacagcg gcggcgcgcc cggtgggctc gccgtatcgc
     6841 tgctctcgct cgccaccgcg ctgccgctcg ccgtacggcg gctgtggccc gtcccggtgt
     6901 tcgcgatcgt cctcaccgcg tcctgcgtgg cgctggccgc cggtctcggc cctgccgtgt
     6961 tcctctccgc ggcctacgcc ctgtacctgg tcgcgacgac acggcgacgg cagctggggc
     7021 ggtcggccgt gatcgtcggc ggggcgagca cggcgggcgc ggccctgctg acggtgacgg
     7081 gcgggcagca ctacacaggc ggcaccctgg cggtgcaact gctgttcggg ctattggtac
     7141 tgggggcgac gtgggccgcg gggacggccg tacgggagcg acgcgagagc ctgcggcgga
     7201 ccatcgtgca ggcgaccgag caggccaagg tcgaagaacg catgaggatc gcccgggaca
     7261 tccacgacgt cgtcacccac agcgtgggcc tgatcgcgat caaggccggg gtcgccaacc
     7321 acgtcatcgc cacccacccc gaggaggccg gagaggccct caccgtcatc gaggacatca
     7381 gccgcagggc gctgcgcgac atgcgggcca ccctcaaggt gctgcgccga gaagacgacg
     7441 cccagcagca ggacctccag ccggtccccg gactgtcgga cctgccttcc ctggtccgta
     7501 cggccgaggc ggcgggcgtc agcgtcgacc tgcgctccga ttgcgtggag gaaccaccgg
     7561 acggggtcgc gctgaccgcg ttccggatcg tccaggaggc gctgaccaac gtcgtcaaac
     7621 acgctgcccc gacccgctgc ctggtcagcg tcaccgcgca ggacggtgtg ctgacgatcg
     7681 gcgtcaccga cgacggcccc ggacccgggc accggccgac cgttcccggc ggcgccatgg
     7741 ggctcgtcgg gatgagggaa cgggccgtcg cgcacggcgg gaccctcacg gcgggccccc
     7801 gccccggcgc gggcttccgg atcctcgcga cactgccgta ctagtgccac gccaaccgcc
     7861 atacgtcccg ccccccgcat atggctgaaa cggtctcata ccccggtatg ggtccggtcc
     7921 gcgaaaccgg cccgcaccgt cccgaccccg gtccgatgtg tggtgcggcc gccgcggcca
     7981 gactcgtcgt gtgattgacg tccagaacct gaccaagcgg tacgggccgg ccaccgtcgt
     8041 ggacggcctg accttcacgg tgcggcccgg agccgtcacc ggcttcctcg gccccaacgg
     8101 cgccgggaag tcgaccaccc tgcggatgat gctgggcctg acccgccccg acaccggaac
     8161 cgcgcggatc gacgggcacg cctacggcga cctggcccac cccctccgcc gcatcggcgc
     8221 cctgctggag acctcggccc cgcaccgcgg cctgaccgcg cgcgaccatc tgctctggct
     8281 cgcccagagc aaccggatcg cccgcggccg ggtcgccgag gtcctggagg cggtcgggct
     8341 cgcggacgcg gcccggcgcc ggaccggcac cttctccctc ggcatgggcc agcggctggg
     8401 cctggccgcc gcactcctcg gcgacccgcc cgtgctggtg ctcgacgaac cggtcaacgg
     8461 cctggacacc gagggcatcc gctggctgcg cgacctgctg cgctcgatgg ccgccgaggg
     8521 ccgtaccgtc ctcatctcca gccatctgat gaccgagatg gccctggtcg ccgatcacct
     8581 ggtcgtcatc agccggggcc ggctcctcgc ggacaccggg atgtccgact tcatcgagcg
     8641 ccacggacgg tcgtacgtcc gggtccgcac cgccgaaccc gaccggctcg gcagggagtt
     8701 ggaaggtcgc ggcgccacgg tgagccgcgt ccccggcggc ggcctggacg tcgtgggcat
     8761 ggcggccgcg gacgtcagcc ggatcgccgc ggcgggcggc ttcccgctcg acgaactcgc
     8821 cacccacgcc gggtcgttgg aggagacctt cctcgacgtc atcggagaag aaggcacccg
     8881 cgcgggagcc gacggcgcac gcgccctcgg tgaggaaggc aggaacaccc atgtctgaga
     8941 ccctcgcggc cgtccgcgcc gagaccacca agctgcgcgg cattcgcggc acccggatct
     9001 cgctgctgct gttcgccgcg gtcagcgtcc tcatcgccgc actcgacggc tggtccgcga
     9061 agaacgcgct ggagtccgac aacccgagcc tgcgttccga cttcaccccg gaacaggccg
     9121 gtctcgacgg catcctctac ggccagttgg cgctgatcgt gttcggcgtc ctcgtcgtca
     9181 ccagcgagta cacgtccggc atgatccgtg tctccctgct cgccgtcccc cggcgcggac
     9241 ggctctacgc ggcgaagacg gtcgtcaccg ccctggcggc ggtggccgtc tccgtccccg
     9301 tcaccgtcct cggctacctg gtcacgcagg cggccctcgg gtcccacggt tcctcgctcg
     9361 gcgcgagcgg tgtcccgcgc gccctggccg gggcggtcgt ctatctgacc ctgatgtgcc
     9421 tgttcgcggc gggtatcgcg gcgatcgccc gcaacgccgt cgtaccgctg gccgttctgc
     9481 tgccgatggt gctcgccggg acgcacatcc tgtccctcat cggggcgacc aaggagatgg
     9541 cccggtactt ccccgaccag gcgggaaacg aactgctcac cgtccggtcc ccgcacacgg
     9601 ccttcggctt cacggtgctg ctcgcctgga ccgtcgccgc cctcggatgg ggctgggtgc
     9661 gccagcgccg gtgggacagc tgacaggacc ggcatgggac aactgcccca tgccggtggg
     9721 acagtccgcc ccgtagcttc cgtgacagat cacaggccga acaaggtcgg cctgaccgat
     9781 ccgaaacggg aggacaccat gtccgcgatc tacgagcccc ccatgctcca ggaagtcggc
     9841 gacttcgagg agctcacgaa gtgcctcggc gtcggaagct gcaacgactt cgccggctgc
     9901 ggctacgcga tcgtctgctt ctggtgatca cgtccggtgc cggtgcgttc acgcgcaccg
     9961 gcaccacccg gggtgacgag gagacgggga acgaggcgac atggaattcg tggttcttcc
    10021 ggactgcccg gccggtgccg ccgcagccgg ccggctgcgg gcgacgcggc gcgtcgatca
    10081 cgcgtcgggg cggccctgga tcgtcggcga ctggcccgag gccgaggccg tcgtcgtcca
    10141 ggcgggccca cggcggatgg tcgtgctggg acacacccgg ctcgacgaga ccgccgcggc
    10201 ggccgcgctc ggccgactgc gctcgctgca cgacgtggac tcgatcgcgt cccggctgcc
    10261 gggagccgtc cacctggccg tgtcactgga cggcaggacc agggtgcagg gttcggccgt
    10321 cggcgtacga cagatcttca ccgccgtcgt cgacggggtg accgtcgccg cgagcggggt
    10381 ggaacccctg ctgcggctga ccggcgccgg cctcgacgag accgtgctcg ccgcccgcct
    10441 gctggcgccg ggcggaccac cctggccgct cgcccagcgc cccgtccgcc ggggcgtcga
    10501 ggcgctcacc accggccact ggctggaact ggacacggac ggccgggccc ggcagacccg
    10561 ctggtgggaa ctcccggagc cgtccctcac gctcgcgcag ggcgcagccg ccgtccgttc
    10621 ggcactggac gacgcgatca ccagccgggt cgccgcgggc ggcaccctca gcgccgacct
    10681 gtccggcggt ctggactcca cctcactgtg cttcctcgcg cacgcggccg gcgccgacct
    10741 ggtcacgtac cacgtgacgc cgatcgacag cgccaacgcg gacacgatgt gggcccaccg
    10801 ggccgcagag tgcctgcctg cggcccggca ccacacgctg tccgccgacc gcgccgagaa
    10861 ccttttcgac gtcggctaca ccaccgacct cgtgggcgcg gccccggagg gtccctcgac
    10921 ctgggcctcc ggactcgccc acatccagga cctcgccaag cgggccacgg cggagggcgc
    10981 cacactgcac ctgaccggct tcggcggtga cgagctgttc ggccggatgc ccgcctgcgc
    11041 ctggtccctg gcccgggcca caccggtcgg cgggctgcgg ctggtcaacc gctaccggct
    11101 ggccaatcgc tggccgtggc gggcgaccgt acgctcgctc cttgaccgct cgacgttcac
    11161 gcagaacctc ggtcgggtcg ccgcccgcat cgacgccccg cccccgcccg tcgacgagcc
    11221 cgacttcggc tgggtgttcg cgccccgcat gccgacctgg gcgacccccg acgccgtggc
    11281 cgcggtccgc gcccttctca cagacgccgc caccgaggga cccgggccgc tggacgccga
    11341 ccgggcccgg caccaggcgc tcgcctcgct cgtcttcgag gggaccaccg tccgccaggt
    11401 caactccgcc ctcggggaca ccggcatcac ctgggacgcg cccttcctcg acgaccgggt
    11461 ggtggaggcg gccctggcca cccggatcga ccagcgcctg ctcggtgggc ggttcaagcc
    11521 gctgctcacc tcggccgcac ggggtctcgt ccccgcggac atcctgggcc gccgtgacaa
    11581 gggcgagttc agcgcggagg cgttccgggg cctggcccgc aaccgggccc ggatcctgga
    11641 gctgtgcgag gactcccagc tcgcccggct cggcctcatc gacccggcgg ccttccggtc
    11701 cgcggtgctg aacccggggc cgatgtccca ccatctccag ccgatcgaca ccacggtggc
    11761 gtgcgagagc tggctgcgga cgcatccgga gacgtacccc atgccacccg cccggaacac
    11821 gcctacggga gaacaccgat gaagctgacc ctcgcccgcg acgtcaccct caccgtcgtc
    11881 gactccgggg ccgtgctgct cgacgggcgc cgcggccgct actggcaact gaaccactcc
    11941 ggtgcgggcg tcctgcgcca actgctcgac ggaacggcgc ccgacgcggc cgccgccggc
    12001 ctgtgcgccg cggccccggt cagcgacgac caggcacggc aggacgtcca ggccctcatc
    12061 gacgcgctca gcgcggccaa gctcgtggag gtggcctcgt gaccaccccc gccgtggccg
    12121 aacaggcccc gcggctgccc tggtaccggc agctcgcccc ccgatgcgcc gcgggggcgg
    12181 cccgtctgct ggtccggttg ccgccggccc gactgcatcg tgtgctgggc gtggtcagca
    12241 aggggtcccg ccccgccgga tacgccgagg tggcgcgggc ccgccggtcc gtcgtctcgg
    12301 tcagcacccg ctgcgcgggc ctcggttgcc tccagcgttc cgtggccacc gtcctgctgt
    12361 gccgggcaca cggcaggtgg gccgactggt gcacgggatt cagaaccgaa ccgttcggcg
    12421 cgcacgcctg ggtggaggcc gaggggcggc cggtggacga gcccggcgaa ctcagcgtgt
    12481 tccgcacggt cctggcggtc cgccgcccgg acggacgccg gagcacctcc gaccgtcccc
    12541 tccgcccctc ccgagggagc cgctcatgac agcgatccgg gccgagggcc tctacgcgta
    12601 ctacggcacc gcaccggccg tgaacgggct cgacctgacc gtgcccacgg gcagcgtcta
    12661 cggcttcctc ggaccgaacg gcgcgggcaa gaccaccacc atcaacatgc tgaccaccct
    12721 gctccggccc accgcgggcc gtgcggaggt ggccggcttc gacgtcgccg cccggcccgc
    12781 cgaggtccgc cgccgtatcg gcatcgtgtt ccaggagtcg accctcgacc tggacctcac
    12841 cgccgccgag aacctccgct tccaggccga cctgtgcggc ctgtcccggc gcgcgtcccg
    12901 cgacgcgatc ggctcgatgc tcgacctgat ggacctctcc gagcgccgca gggtgcccgt
    12961 acggcagttc tccaccggac tgcgccgccg cctcgagatc gcccgtggtc tgctcgccga
    13021 gcccagcgtg ctgttcctcg acgagccgac gaccggactg gacgcccaga cccgcgccgc
    13081 cgtctgggag cacctggaac ggctgcgccg ggagaggggc atcacggtct tcgtcaccac
    13141 ccatcaactg gacgaggccg agcactgcga ccggatcgcg atcatcgacc ggggcaaggt
    13201 ggtcacggag ggcacacccg cggacctcaa gtccgtcatc ggggccgacc tcgtcgtcct
    13261 gcgcaccgac gacgaccagc gcgccgccgc cgccatcggc gaccggttcg gcctcccggc
    13321 ggagcccact ccggacggtc tgctgctccg ggtcgagcgc gcggcggccc tggtgccccg
    13381 cctgtgcacc gaactcggcg tgaccgtacg cgaggtcgcc atcgccccac ccaccctcga
    13441 cgacgtcttc ctgcaccaca ccggtctcgc catccgggag agcccgaccg gcccgcgcac
    13501 gctcggcaac ctcggggaag gactgcgatg agccggaccg acaccgcacc cgccgcactc
    13561 ggcgacgtca gcaccgcacc atcaccgacc gaccggtccc gcaacgcggc gcgccccgtc
    13621 ctgctgctct ggcggcggga gatgacccgg ctgcggcaca accccgtgcg cctggccatg
    13681 ggactcgtga caccgctgct gttcctcgtc gtcctcggca ccggcctcga cgcggcgtcg
    13741 tccagcctcg gcaaggccca actgaacgac taccgggcct acttgtttcc cggcacgctg
    13801 gtcatgtccg tgcaggcgcc ggcgatcgcg gtgggcatct cgctggtgtg ggaccgcagg
    13861 ctgggggtgc tgcgccagat gctcgtggcg ccgttcccgc gcgcgtccat cgtgttcgga
    13921 ctggccctcg gcggcgccac caccggcgcg gtctacggcc tcatggtgct gtccgtcggc
    13981 gggatcgcga gcatccgcta cacgccgatg ctgctggtcg tcctcctcga actcctgctg
    14041 gtctccctca tgttcaccgc gctcgggctg ctcgccgccg tcaccatccg gcaggtcgac
    14101 accttccagg tcgtggtgaa cctgagcctg atgccgctga tgttcttctc cggcgcgatg
    14161 ttcccgccca acggcctgcc cggctggctc gacaccgtcg tcaagctcaa cccgctgacg
    14221 tacggcgtcg acgcggtccg ccggaccctg ccaggaccga gcgtgctcac ctcggagcag
    14281 acccggctga tgctcggcga ctggcatccg cccgtggccg ccgaactggg tttcctggcc
    14341 gccctcaccg cggtcgcgct gggcctcgcc ggctaccggt tctcccgtac gtcatgaggc
    14401 cgggaggaca gagcacggtg gacgcgagca cgacggatgt gaccacgacg gccgccgtcc
    14461 gggccacgac cgggcactgg gcgggcgcgg cgcggttcgt ggcccggctg ctcctggcgg
    14521 cggtcctggc ctacgccggt ctggtgaaga tcggggacct cacggaggcc gggcggacgg
    14581 tcgcgctcta ccgcatcgtg cccgccgact cggcccaact cgtgggcggt gtcctgccgt
    14641 tcgtcgaggt ggcgctcgcg ctgctgctcg cggccgggct ggccaccagg gcggcagcgg
    14701 cgggagcggc cgtactgctg gtcgcctatg cggcggccat cgcctcggtg tgggcacggg
    14761 gcatgtccat cgactgcggc tgtttcggcg gcggaggcac gctcagcggt ggcgccgcac
    14821 gcggctacgc gctcgacctc gcgcgcgatc tgctgctgct cggcgcggcc gccctcctga
    14881 tccggaatcc gcgcacccga tacgcgctgg acggctgggt cctggacccg aaggagtgag
    14941 gggcatgacg agcacacaga caacggacgc cacggtgcgg gagatggtgc accgacggca
    15001 gcggcgacgg cgcacagtgg tggtgtctct ggtggccgcc ctggtggtgg tcgccgccgc
    15061 gctggtgggc gcgggcctgg tccgggcgaa caacacggcg cccggcaagg caccgagccg
    15121 cgtaccggcc ggactcgccg ccgacaagtc gggcgtggcc gcctccaccg gcgccgtacg
    15181 cgtcgacgtg tacctcgact acctctgccc cgaatgccgt cgtaccgaac gggcactgac
    15241 caccgccctg gacagtctga gggcgcacgg cggggtgagc gtcgtctacc acccggtcgc
    15301 cttcctcgac gaccgcagcg cacccgcggg ctactcgaca caggcggcgt ccgcggcggc
    15361 ctgcgcggcg gacgcgggga ggttcgagcg gtactccacg gtcctgttct cgaaacagcc
    15421 cgccgaacag ggcccagggc tcagcgaggc ccagctgatc gcggcgggcc gggacgccgg
    15481 catcaccgcg gcgtccttcg cccgctgcgt cgaggacgcc ccctacctgc cctgggtacg
    15541 gtacgtctcc gatctcgccg cctcccgcaa ggtggcgctg accccgaccg tcatggtgga
    15601 gggccgccgc gtcgacgtca ccggctccga cccgggcggc gcgctgaccc gggcggtcac
    15661 ggcggcccgg cggtgacccg gctgaccgtg gccctgtccg gggactgcat ggcgacacgg
    15721 ggagcggtga tctcctccga cccggccgcc ggacggctcc acgaactcct cgacggcgcc
    15781 gacttcgccg tcaccaacct ggaggtggtg cccagcgacg gacgcggaca cccggtgcac
    15841 aacgcggccg gtggcggctg tctgatcgcg gactccggtg tcctggacga gatcacggcg
    15901 gccgggttca ccgtgctggg ctgcgccaac aaccacgcca tggacctggg cacggagggc
    15961 gtgctcggca ccgtggacct gctgcggtcg aggcggatcc cgttcgccgg gatcggcgcc
    16021 gacctcacca cggcgcgccg gcccgtctac gtcgaccggg cgggcggcag cctggcgctg
    16081 ctcgcctgca ccgcgacgtt cctgcccggc caggaggcgg ccgatccgtc gccggaacta
    16141 cccggacggc cgggcctcag cccgctgcgc cactccgcga ccctgcgggt gacggccccg
    16201 cagatggacg tgctgcggac gatcgacgcc gagacgggcc tgcgcgcccg ccgggccgag
    16261 gcccgcaccc tgctcggggt cgaccccgcc ctcctcggac ccgaccggct cagtctcttc
    16321 ggcacccgct tcctgacggc ggacgaaccg ggcttcacga ccgagtgcga tccgcgcgac
    16381 ctcgacgaga tctcccgctg ggtcggtgag gcccgcctcc gcgcggacct cgtggtggtg
    16441 agtgtgcact cccacgagcc cggcccgacg cccgagacac cgggcgagtt cctacgtgtc
    16501 ttcgcgcacc ggatgatcga cgagggcgcg gacgtcgtgg tcgggcacgg cccgcatttc
    16561 cttcgcggtg tcgagctgta ccggaacagg ccgatcttct acagcctcgg caacatcgtc
    16621 agtcagatcg aactgaccga ccgcgtctcc gcggaggact acgccaaggt caccaccgac
    16681 cggccgccca ccccgggccg ctactacgac cggctgagcg gccacggcac ccggttgttc
    16741 gccccccacc gccgctactg gcagtcgctc gtgccggtcc tcaccttcga cgacggcacc
    16801 ctcgtgacgg cccgcctcca cccggtcgac ctcggcttcg ccctgccggt gcaccgcagg
    16861 ggccgcccac gcctggccga ccaggccgag gccaaggaga tcctcaccga ggtcgcccgg
    16921 ctgtcggagt cgtacggtac gacggtccgg gcgggggtcg acggcacggc ggagctgctt
    16981 ctggacgtgg cgtgaagggc cgtgcgtggc gggcgagttg atgagagagc cttgctaaaa
    17041 tgtcatatgt cacctacgag cggacgagga accggggaac acgcatggcc gagtcggtcc
    17101 gggtactgat cgcggacgac caggcactgc tgcgcgggag cttccgggtc ctcgtcgact
    17161 ccacacccgg catggaggtc gtcggcgagg ccggcgacgg cgccatggcg gtccggctcg
    17221 cccgggaact cgccccggac gtcgtcctga tggacctccg gatgccggtt ctcgacggca
    17281 tcgcggccac ccgggagatc tgctccgacg agacgctgac cggtgttcgg gtgctggccc
    17341 tgaccatgtt cgacatggac gagtacgtct acccggccct ccaggcgggt gccagcggct
    17401 tcatgctgaa ggacgcctcg ccgtccgacc tggtcgacgg catccgggtc atcgccacgg
    17461 gcgagggtgt actggccccc acggtcaccc ggcgcgtcat cgccaacttc tcccggcgcg
    17521 gcgagacgcc ccgccccgct ccacgactcg tcggtctcac caagcgggaa cacgaagtcc
    17581 tcgtccagat cgccaacggc ctgtccaacg cggagatctc cgaacgcctg gtcatcagca
    17641 tgccgaccgt gaagacccac gtcggcagcc tcctggccaa gctgcacgcc cgggaccgcg
    17701 cacagctggt catcatcgcg tacgagagcg gcctggccga gcggggaatg ccgacgtgac
    17761 cgcggcgacc aggactcacg gcgcggcgcc ccgctgggcg gctgcgcggg ggtggccgtc
    17821 gtcgccggtg tcgcaggttc gaaacctgcc ggggcacagc gagaagggca cctacggatc
    17881 gccgtaggtg ccccttttgc atccaggtct gacgaccgga tcgccgcgga ccgcgacggt
    17941 cccccgaaca gaggcccccg ttgttactga agccattggg ccgttcggag gagtcggggc
    18001 agcgagacag ccaagggcgt cacgggccgt cagctgcttt tttcctgctc tcagcgtgat
    18061 tccacgccag gacagggccg acacccaggc ccctccacag cgtcaatggc ccatacaagg
    18121 gagagttacg gatatatctg cactttgtaa cgcgaatcgt ttccttggcc tggtgtcgca
    18181 gtggagggcc acagtgtggg cctcggcacc gagccgggaa tgacggattg cacgcccggc
    18241 cccgaccagg gtcggtgtgc acgaacgtga ggtgacagat tcatgtctgt ttctcgtaag
    18301 gcggtccgcc tgatcgccac ctgtgtggct acgggcgcgc tcgtcggcgc ggccgccatg
    18361 ccggccctgg ccgccggagg cggccacgac cgcgacaacg ggaggggtta ctcgcacagt
    18421 tacaggagcg accacgacca cggcggccac ttcggcgacc gggaccggga ccgcgaccgc
    18481 gaccggggct ggggctgggg cttggaccgg ggccacgacc ggggctggga ccggggtcac
    18541 gaccgggacc gggaccggga ccgcggctgg gaccgaggcc ggggctggga ccggggcgag
    18601 cgccacggct ggtacagcga ccggcaccgg gatcaggacc gctacctcgg ccaccactag
    18661 cccgccttgg cgactgtgct gcgacgcgga ggcccacacc cactgccacc cgtcgtcatg
    18721 accggcacgg ccgctgtacc cagccggagg gccgaagacc gttccttgcg gtcttcggcc
    18781 ctccggccac gtgtcgcacg acacccacaa ggttcacctg atcaaattca ccgcgccggt
    18841 gtccctggta gcacttgcgc tcgcgagtgc tccgctggcc tctcaagccc aggccctggt
    18901 catgccgctg ggcgtgaacg cccggcatgc gcctggcact ccggggggcc cacaggcccc
    18961 ggtcacggtg ttcaccgaag acggtggagt tccggaccga gcggccgatc ccgatcgcga
    19021 agccgaaccg ctacatcacc ttcgcagtgg atgtagccgc cgtgaattgc ggccaagccg
    19081 ttcctccgct gctgaagttc tatctgaccg gcaacggggc agacatcccg accttcacca
    19141 cccccatcaa tccctgcgcc gaccccaact ccaagcccta tcccggagga aacgggttga
    19201 gggccggggc gttcgccggc aacagagccg tactgttcaa cgatagccag ttgggcatca
    19261 agatggtcaa cgggcaaggc gaatggttcg gcaatgacca tgcgttcgac aacatccgga
    19321 tcctggatgc gactccgcaa ttggacaagg cgttcagtcc tgccaccgtg gacaagggtg
    19381 gcacctcgac gctcaccatg acggtgacga acaccagtga actggcggcg aagaacgact
    19441 tcagcttcgc cgacaacctg cccgccggag tgaaggtggc ctcgaccgcg aacgcgtcga
    19501 cgacctgcgg caacggcacg gtgtccgcgg cgtcgggggg cacgtccgtc gctctgaacg
    19561 gcggcgacct ggccgccggc gagaagtcct gcacggtcac ggtgaacgtc acagccgaca
    19621 aggcgggaac ctacgtgaac cgccccgaag cgatcaccac ggttggcctg aatcccacgg
    19681 accccgcgac gctgaccgtc aagatgaagg gagcaacagc ggtgggcacc gcgacgggct
    19741 cgggcggtct gctgtccggc aatgtggtgc aggtacccgt gaacatgccg gtcaacgcct
    19801 gcggcaactc cgtgaacgtc atcggactgc tcaacccggc ggcaggcaac gtctgcgtca
    19861 acggctagcc gatcgtcggg ctgacccgac cgaactcctc aagcggtgtc gcaggttcgc
    19921 atcctgccgg aggcacgagg cctgaacggg ccgcatgtat cgaacagccc ccacggagca
    19981 ttctccgagg gggctgtttc atgcgtgcgg gaacaatgcg ggaccccctc aagctttgct
    20041 caattccctg gtccggattg gagaactcat gcgaacatcg cgtggtccgc tgccatccga
    20101 ccaggtggcg ggcatgattc agggggaatt tccatgcttt tttcgccgaa gtcgccagcg
    20161 taccgccatg accaccgtgc actggcagcc gtcggcgcgg cgcccgtttc atcgatccgg
    20221 gccttgtcgt gcgaagcggt gcaacgtccg gcccggctgg gacacctctg tcaagtctga
    20281 tcgaacctac ctgtgttccc aggtggttct caccagcgag accgctgaag gccccacgaa
    20341 atatggctca actctgtgcc gtgggagcca gtttcggcga gcgcgatata ggtgacaggg
    20401 aagttcccag ggcggtagcg cggctgagcc gccaccggta ccacctcgtg gcatcaaagg
    20461 gaatggcggc cgtagtgctg ccccgtgccg ttgtgtgcaa ctgaccacct cacccatcac
    20521 gttaccgccg gctttccgcg gaaccactcg ggacagcaag ccaattctgg ccacccgcga
    20581 gttggcggaa ggtcgatttc tcgtgcccag attccgtgaa acccacagga gtggaacgtt
    20641 gtcgtatcga agacacctgc cagtcgtcgc cctgctgtgc gcggccgtgc tcggcaccgc
    20701 agccccgaac acatgggccg tgtcaccgtc accgcgtccg tcctccgccg cggaccctgc
    20761 cacgccgacc gccacgaaca aacctcgacc agtcgcgtca gcgtcggcgt ccgcacctac
    20821 gcggagcccc tctacggtcg tctctccgcc cgcggtctca tccccgtctg cgacctcgtc
    20881 cccgtccccg tctccggggg cggctgcggg ccatgaggct caggaggctg ccaagtactg
    20941 gaccgcacag cgcatggcca acgcccgacc gctggacgcc ctacggtcgg caccgtccgc
    21001 ccgcaaacac gcaatgccgg cggcggggaa cgcctctccg aacggcaccc tgttcggcgg
    21061 aacccgcctc gtaggaacgt tcttcggctc cagcagccca accggtacga actggtcgtg
    21121 cacgggcagc gtgatcgaca ccccggccag aaacgtgatc ctcaccgcgg cgcactgcgg
    21181 actcggctac agcaacaact acatcttcgt accgaaattc atcaagggcg cggggcccga
    21241 ccagcagccc tacggcatct tccacatcca gcacgtcttc atcgaccccc gctacatacc
    21301 tgacacgggc cattcgtcga ccaagaagcc ctggtccgat ctggacaccg cgttcgcgcg
    21361 cgtctcggcg aatcagcgcg gcaggcagct ccaggacgcc gtggggggag ggctgacctt
    21421 cacccagccg accggctaca accacaacga tgtcacggtc gtgggctatc cgggcaagga
    21481 ccacaacggg gccgggcaag ccatcaagtg caccgtaccg acgacgcaac tgcctgggtt
    21541 ccgtcagatg tcgatgacct gtggcggcta ctacggtggc gtctccggca gcccgtggat
    21601 caccgactac caggacgacg cacgcaccgg ccatgtcatc ggcaacctcg gtggctacaa
    21661 cggcggcggg aacgacgcgg acgtcgacta catcagctac gccccggcgt tcggttccga
    21721 cgccgccaac cttctcgccg acgccatagc caaccaggac cctccgtcca acctgccccc
    21781 gtaccagggc atccaggcga agctccccgg aggagcgacg ctgtggcagc acgcgaaact
    21841 gctggcctcg ggcgactaca cgggcaaccg ccgcagcgac atgatcgtgg tctggtccga
    21901 cggcgaagtc accttgtacc ccggtgacgg caagggcggg ttcctgccgg agagacggct
    21961 tcaggcaccc aactccacct ggacacacgc ggagaccgtc acaggcggag acttcaccgg
    22021 ctccgatctt tccgacctca tggtgcgctg gtccgacggt gaggtcactc tctacccgga
    22081 cgtcagcgct tcgggcctga gcggagaagt ccagatggcg ccctccggct ccctgtggaa
    22141 gaacgcaatt cagatctcgg ccgggcagtt ccacaacggg aagtacgcca cggacctgat
    22201 ggtgcgctgg gtcgacggcg aactgaccct ctacacctat gtcggtgccg gcaccttcgg
    22261 gaccgagaac cgcctgctgg ctccgaacgg cacctggaag aacgccacct tgctgaccag
    22321 cgggaacttc agcggcaagg ccaactggga cgttctcgtc cgctgggtgg acggcgagct
    22381 cgacacctac gtggccacct cgaccgcggg cctcggcgcc gaggcccgca tgcgcgaccc
    22441 caacgacctg tggaagcacg acctggtcat gacggcgggc aactacacgc ccaatggctt
    22501 cagcgacgac ctgatcgttc gctggtccga cggcgagacc acgctgtacg ccgataccgc
    22561 ctacacgtc
//
