LOCUS       NZ_CP041610            10405 bp    DNA     linear   CON 14-NOV-2023
DEFINITION  Streptomyces sp. RLB3-17 chromosome, complete genome.
ACCESSION   NZ_CP041610
VERSION     NZ_CP041610.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RLB3-17
  ORGANISM  Streptomyces sp. RLB3-17
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66.0x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/14/2023 04:19:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,027
            CDSs (total)                      :: 10,924
            Genes (coding)                    :: 10,421
            CDSs (with protein)               :: 10,421
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 503
            CDSs (without protein)            :: 503
            Pseudo Genes (ambiguous residues) :: 0 of 503
            Pseudo Genes (frameshifted)       :: 178 of 503
            Pseudo Genes (incomplete)         :: 409 of 503
            Pseudo Genes (internal stop)      :: 52 of 503
            Pseudo Genes (multiple problems)  :: 128 of 503
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3195644
            Orig. end                         :: 3206049
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041610.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041610.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="16"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5405
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(262..1110)
                     /locus_tag="FNV62_RS14910"
                     /old_locus_tag="FNV62_15130"
     CDS             complement(262..1110)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121392.1"
                     /locus_tag="FNV62_RS14910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15130"
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_054232281.1"
                     /transl_table=11
                     /translation="MNSVLGRRTRILAATTATAGLLLVAGCSSGGGGGQSSAKGVPLVK
                     AGQVTTCTHLPYPPFQSEINGKVQGFDVALIDLVAGDLGVKQAIVDTPFENFKTGAFLN
                     SGQCDLAAAGMTITPERKKNVDFSDPYFDATQAVLVDKKSGVNSLADVKAKGKKLGAQA
                     QTTGEEYAAKQGFDSVSFESSDAVLNGLRTGQVQAVIIDYPVVQGWLKDKANADAFKVV
                     DNLNTGEQYGFTVKKGNTKLLAEINRAIKQAKADGTYKKLYEKWIGPYPASAATASPSA
                     S"
     gene            1348..2448
                     /locus_tag="FNV62_RS14915"
                     /old_locus_tag="FNV62_15135"
     CDS             1348..2448
                     /NRPS_PKS="Domain: Aminotran_5 (73-258). E-value: 9.7e-26.
                     Score: 82.4. Matches aSDomain:
                     nrpspksdomains_FNV62_RS14915_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477727.1"
                     /locus_tag="FNV62_RS14915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15135"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_144316473.1"
                     /sec_met_domain="Aminotran_5 (E-value: 9e-20, bitscore:
                     70.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLSAAHFAAIEDRVARLLSTEQDVVIMQGEALLPLE
                     GAIRAAAGPGTTALNVITGPYGQTFGDWLRDCGATVIDLAVPFHTAVTAAQVRDAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGKVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWVDGGRKALLHAP
                     AQLEMLALEACVERIEAEGLDAVMRRHALAGAATRAGAVALGGGLEPYVYEAGDAAPVA
                     TTLRAPSGVDAGVLVARALAADPALPLVAGGGALAKEMIRVNHYGPDATPGVVHSCLAA
                     LGAAMAESGLTIDLEAARRATTKAWS"
     aSDomain        1567..2121
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FNV62_RS14915_Aminotran_5.1"
                     /evalue="9.70E-26"
                     /label="FNV62_RS14915_Aminotran_5.1"
                     /locus_tag="FNV62_RS14915"
                     /protein_end="258"
                     /protein_start="73"
                     /score="82.4"
                     /tool="antismash"
                     /translation="LRDCGATVIDLAVPFHTAVTAAQVRDAFAEHPEIDFVSLVHAEAA
                     TGNTNPVAEIGKVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCVIGAQKAMGGPAGVS
                     AVSVSERAWARMAANPGAPRRSYLSLLDWKERWVDGGRKALLHAPAQLEMLALEACVER
                     IEAEGLDAVMRRHALAGAATRA"
     misc_feature    2869..2884
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    3003..3015
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            3040..3579
                     /gene="ectA"
                     /locus_tag="FNV62_RS14920"
                     /old_locus_tag="FNV62_15140"
     CDS             3040..3579
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661364.1"
                     /locus_tag="FNV62_RS14920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15140"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_095855368.1"
                     /transl_table=11
                     /translation="MTAARADLQAEFLEMPEGLRIDRPKVADGAALWHIAKDSGTLDLN
                     SSYSYLLWCRDFAGTSAVARDADGVPVGFVTGYVRPERPGTLLVWQVAVDAAHRGRGLA
                     AALLDGLTARVAEQRTITAVETTITPGNTASERLFTSYARRHGARVEHEVLFEAGQFPD
                     GPHDPEVLYRIGPLPG"
     gene            3668..4939
                     /gene="ectB"
                     /locus_tag="FNV62_RS14925"
                     /old_locus_tag="FNV62_15145"
     CDS             3668..4939
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 2.2e-72.
                     Score: 235.8. Matches aSDomain:
                     nrpspksdomains_FNV62_RS14925_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381147.1"
                     /locus_tag="FNV62_RS14925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15145"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_097284147.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1e-76, bitscore:
                     257.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIIQPDLSVFETLESEVRSYCRSWPTVFDRARGSRMFDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTTAKRAFLEAFQNLVLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDHYFDGQVPDFLWFERLLEDQGSGLNQPAAVIVETVQGEGGINVARP
                     EWLRALADLCRRRDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTVSKSISGYGLPMS
                     LCLFKPELDVWEPGEHNGTFRGNNPAFVTAAAALETYWSDGSAMEKQTRARGEQIEQAL
                     ISVTEENLADVKEYRGRGLVWGLEFHEKERAGRVAQRAFELGLLIETSGPESEVVKLLP
                     ALTITPDELDEGLRTVARAVRETV"
     aSDomain        3752..4765
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FNV62_RS14925_Aminotran_3.1"
                     /evalue="2.20E-72"
                     /label="FNV62_RS14925_Aminotran_3.1"
                     /locus_tag="FNV62_RS14925"
                     /protein_end="366"
                     /protein_start="28"
                     /score="235.8"
                     /tool="antismash"
                     /translation="FDRARGSRMFDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLE
                     RDGVTHGLDMSTTAKRAFLEAFQNLVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDHYFDGQVPDFLWFER
                     LLEDQGSGLNQPAAVIVETVQGEGGINVARPEWLRALADLCRRRDMLLIVDDIQMGCGR
                     TGAFFSFEEAGIVPDIVTVSKSISGYGLPMSLCLFKPELDVWEPGEHNGTFRGNNPAFV
                     TAAAALETYWSDGSAMEKQTRARGEQIEQALISVTEENLADVKEYRGRGLVWGLEFH"
     gene            5001..5405
                     /locus_tag="FNV62_RS14930"
                     /old_locus_tag="FNV62_15150"
     CDS             5001..5405
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643612.1"
                     /locus_tag="FNV62_RS14930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15150"
                     /product="ectoine synthase"
                     /protein_id="WP_054232284.1"
                     /sec_met_domain="ectoine_synt (E-value: 3.1e-53, bitscore:
                     178.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKAATGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCVAGEAELTNDETGETHWITPGTMYLLDGHERHTMRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEPEEV"
     gene            5412..6323
                     /gene="thpD"
                     /locus_tag="FNV62_RS14935"
                     /old_locus_tag="FNV62_15155"
     CDS             5412..6323
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477733.1"
                     /locus_tag="FNV62_RS14935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15155"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_143601269.1"
                     /sec_met_domain="PhyH (E-value: 3e-38, bitscore: 131.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTTTSTTTVTDLYPSRGATEVSVPRQDPVVWGTPGTPGPFSV
                     PDLQAYERDGFLAIEELIGEDDVALYRAELERLVTDPAIRADERSIVEPATQEIRSVFE
                     VHRISEVFAALVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAE
                     DGLANMRTVSVSIALTENHDTNGGLMIMPGSHKTFLGCAGATPRDNYKKSLQMQDAGTP
                     SDEALTRFADRHGIKLFTGRAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENAAV
                     EPFAAPVRRPEFIGARDFTPVQ"
     gene            complement(6391..7440)
                     /locus_tag="FNV62_RS14940"
                     /old_locus_tag="FNV62_15160"
     CDS             complement(6391..7440)
                     /NRPS_PKS="Domain: Aminotran_5 (16-343). E-value: 2.6e-24.
                     Score: 77.8. Matches aSDomain:
                     nrpspksdomains_FNV62_RS14940_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477739.1"
                     /locus_tag="FNV62_RS14940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15160"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_143601270.1"
                     /sec_met_domain="Aminotran_5 (E-value: 6.3e-18, bitscore:
                     64.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METFESLVRAEFAPKNTYLNTASCGLLPARTVEAMRVAVESVADG
                     RPSDMFDDVEAARAAFARLAGVPAGRVAAGASVAVYSGLIAASLPPGAEVLTAEDDFSS
                     VVNPFHVRGDLKLRAVPLERIAESVRPGTALVAVSAAQSADGRIADLAGIARAAREHGA
                     RTYVDVSQAAGWLPIQADAYDFVSSVAFKWLVCPRGVAFLVVPEDLGGLTPVFAGWVAG
                     EAPWDSCYGPVAELAHSARRFDESPSLFSYAGARHSLELFEELGVANVRAHDLALADRF
                     RAGLQGLGQTPVSAPGSPIVSVPGLGRRQQELSEAGVEVSDRAGNLRAAFHLYNTPADV
                     DRLLDVLSG"
     aSDomain        complement(6412..7392)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FNV62_RS14940_Aminotran_5.1"
                     /evalue="2.60E-24"
                     /label="FNV62_RS14940_Aminotran_5.1"
                     /locus_tag="FNV62_RS14940"
                     /protein_end="343"
                     /protein_start="16"
                     /score="77.8"
                     /tool="antismash"
                     /translation="TYLNTASCGLLPARTVEAMRVAVESVADGRPSDMFDDVEAARAAF
                     ARLAGVPAGRVAAGASVAVYSGLIAASLPPGAEVLTAEDDFSSVVNPFHVRGDLKLRAV
                     PLERIAESVRPGTALVAVSAAQSADGRIADLAGIARAAREHGARTYVDVSQAAGWLPIQ
                     ADAYDFVSSVAFKWLVCPRGVAFLVVPEDLGGLTPVFAGWVAGEAPWDSCYGPVAELAH
                     SARRFDESPSLFSYAGARHSLELFEELGVANVRAHDLALADRFRAGLQGLGQTPVSAPG
                     SPIVSVPGLGRRQQELSEAGVEVSDRAGNLRAAFHLYNTPADVDRL"
     gene            complement(7557..8276)
                     /locus_tag="FNV62_RS14945"
                     /old_locus_tag="FNV62_15165"
     CDS             complement(7557..8276)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067467.1"
                     /locus_tag="FNV62_RS14945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15165"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_054232287.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALDAFPHRDEVEVVHRSFELDP
                     GRAKGDIQPVLKMLTKKYGMSEAQAQAGEENLGAQAAAEGLAYRTRDRDHGNTFDMHRL
                     LHFAKERGRQDELIGLLYKANFAEERTVFNDDERLVELAVAAGLDADASREVLADPKAY
                     ADEVRADEREAAELGANGVPFFVLDRKYGVSGAQPAEVFAQALTQAWGERPPLKLIQDG
                     AADAEACGPDGCAVPQP"
     gene            complement(8354..8860)
                     /locus_tag="FNV62_RS14950"
                     /old_locus_tag="FNV62_15170"
     CDS             complement(8354..8860)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004002240.1"
                     /locus_tag="FNV62_RS14950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15170"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_143601271.1"
                     /transl_table=11
                     /translation="MISTPGTTGPLVIRTALPSEAAAITELHLRARSTYYPDGLPFGDV
                     DWVAAWRGSIERPEAHVLCAVRDGHLVGIASFRTADDAPADTVKLFQFHVDPDCWRQGI
                     GRALHSACLEQWRADGKHTATLDVHVDNARAQAFYARQGWVPDPENPPAEGDHHLFLRY
                     AVTGE"
     gene            complement(8925..9533)
                     /locus_tag="FNV62_RS14955"
                     /old_locus_tag="FNV62_15175"
     CDS             complement(8925..9533)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436202.1"
                     /locus_tag="FNV62_RS14955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_15175"
                     /product="DUF1349 domain-containing protein"
                     /protein_id="WP_054232288.1"
                     /transl_table=11
                     /translation="MDVELPELPFPLRTYGPDGHWSHEDGILTGWAGPRQDRFVPPTDE
                     ALDPASDAPRLLGAPEGDFQLIARVTVGFGAAFDAGVLYVHVGERAWAKLCLEYSPDVP
                     TVCTVVTRGHSDDANSFTVDGSSVWLRISRTGRAFAFHASRDGKRWTFIRLFTLGEEKE
                     TSAALVGFMTQSPMGEGCVVTYDGIEFRPNWPKDLRDGS"
ORIGIN
        1 ggccgagcac gagaccgacg acgaagccgg acatcgtgta gagcacggtg ttcttcagcg
       61 ccagtgtgat gacgtccggg aacatctgct tgaccaggtc ccactgcgcg aactggttct
      121 tcagacgtcc ccagtccgcc gtgaccgcga aggcgatcac ggcggcgacg aagacgacgt
      181 actgcgcgcc gcgcgagagg gcgcgcttct ggcgccgggt caggccggac tttcggggct
      241 ggagccgtgc gtcggcatca ctcatgaggc ggacggcgag gcggtggccg cggacgcggg
      301 gtacgggccg atccacttct cgtagagctt cttgtacgta ccgtcggcct tggcctgctt
      361 gatcgccctg ttgatctcgg cgaggagctt ggtgttgccc ttcttgaccg tgaagccgta
      421 ctgctcaccg gtgttgaggt tgtcgaccac cttgaaggcg tcggcgttcg ccttgtcctt
      481 cagccagccc tggacgaccg ggtagtcgat gatgacggcc tggacctggc cggtgcgcag
      541 gccgttcagg accgcgtcgg aggactcgaa ggagaccgag tcgaagccct gcttcgccgc
      601 gtactcctcg cccgtggtct gcgcctgggc gccgagcttc ttgcccttgg ccttcacgtc
      661 ggcgagggag ttgacgccgc tcttcttgtc gaccaggacg gcctgggtgg cgtcgaagta
      721 cgggtcggag aagtcgacgt tcttcttgcg ctccggggtg atcgtcatgc cggccgcggc
      781 gaggtcgcac tggccggagt tgaggaacgc gcccgtcttg aagttctcga agggcgtgtc
      841 gacgatggcc tgcttcacgc cgaggtcccc cgcgaccagg tcgatcagcg cgacgtcgaa
      901 gccctgcacc ttgccgttga tctccgactg gaacggcgga tacgggaggt gggtacaggt
      961 cgtgacctgg cccgccttga ccaggggaac gcccttggca ctgctctggc cccctccgcc
     1021 gcccgaggaa cagccggcca cgagcagcag cccggccgtg gcggtggtgg cggccagaat
     1081 gcgcgtccgg cgtccgagga ccgagttcac ggagacctcc tgtgggggga atggaggatt
     1141 ccgattataa ggaaaggttt ggctcgctca aaccaatccg atggctgttg cgccgttcgg
     1201 cctcagaagt catgcctcgt gcggccgtcc ggtcgtacga cctgggggtg tccgctcgta
     1261 cgaccgagga tcgccgcggg cgtgacaagg gcgcccggat acgctcgggg ctgcgcattg
     1321 gaacctgtga gcgaagagag caccgccgtg acccatccct tcctggacct cgccccgctg
     1381 agcgccgcac acttcgcggc gatcgaggac cgcgtggcgc ggctgctctc caccgagcag
     1441 gacgtcgtga tcatgcaggg cgaggcgctg ctgcccctgg agggtgccat tcgcgccgcg
     1501 gccgggcccg gcaccaccgc gctcaacgtg atcaccgggc cgtacgggca gaccttcggg
     1561 gactggctgc gggactgcgg cgcgacggtg atcgacctcg cggtgccgtt ccacacggcg
     1621 gtgacggccg cacaggtgcg tgacgccttc gccgagcatc cggagatcga cttcgtctcg
     1681 ctggtgcacg cggaggcggc gacgggcaac acgaaccccg tcgcggagat cggcaaggtc
     1741 gtgcgtgcgc acggcgcgct gttctacctc gacgccgtcg cctcgatcgg cgcggagccg
     1801 gtgctgccgg acgcgtgggg ggtcgacctg tgcgtgatcg gggcacagaa ggcgatgggc
     1861 gggccggccg gggtgtcggc cgtgtccgtg agcgagcggg cgtgggcgcg gatggccgcc
     1921 aatccggggg cgccgcgtcg gtcctacctc tccctgctgg actggaagga gcggtgggtc
     1981 gacggcgggc gcaaggcgct gctgcacgcg ccggcgcagc tggagatgct ggcgttggag
     2041 gcgtgtgtcg agcggatcga ggcggagggg ctcgacgcgg tgatgcgccg ccatgccctg
     2101 gcgggggcgg ccacgcgggc gggggcggtc gctctcggtg gcgggctgga gccgtatgtg
     2161 tacgaggcgg gggacgccgc gccggtcgcc acgacgttgc gggcgccgtc cggggtcgat
     2221 gcgggggtgc tggtcgcgag ggcgttggcc gcggatccgg cgttgccgtt ggtcgcgggt
     2281 gggggtgcgc tggcgaagga gatgatccgg gtgaaccact acggccccga tgcgacgccg
     2341 ggggtcgtgc actcctgcct cgcggcgctg ggggcggcga tggccgagtc cggtctcacg
     2401 atcgacctgg aagcggcacg ccgcgcgacg acgaaggcgt ggtcctagcc gtacgtcacg
     2461 ggcgggtgtg tcgggtgcgg gtgggtgggg gcttggcgcg cagttccccg cgcccctggg
     2521 gcgcggggct gcgccccggc gccccatcgg cctcgtcctc gcgcgccgga cgagctgggg
     2581 gcttttaggg gcgcggggaa ctgcgcgacc agcccccacc cacccgcacc cgaagaacac
     2641 accgggatcc ggggcggagc cccggcgtgt tctccccacg gagttaccgg ggcttaatcg
     2701 cgcatcaatt gaagaggcgc tcaccatggc actcaccatg cttattcttg cattaactcg
     2761 aagattagct tcccgtattc ttctgcccgc tttcccggtc cctaaacgca aagatttcgc
     2821 gaacgccaac cgacgtaatt cgggcacgtc tcgtggtgat tacgtgtctg tgacgcactc
     2881 cacactgcgt ccacttcctc ccctattttc cgggcaaacc gtccccttat accactcgca
     2941 gcaccccgct ctcacgggcg cgtgataaca caacggcgcg tcgtacgtaa ccccggacga
     3001 cgatgcaatt tgagatttcc ctcggtaaat tcaatccgca tgaccgccgc acgagcagac
     3061 ctgcaagcgg aattcctgga aatgccggag ggccttcgga tcgaccgtcc gaaggtggcg
     3121 gacggagccg cgctctggca tatcgccaag gactccggaa ccctcgacct gaactcctcg
     3181 tacagctatc tgctgtggtg tcgtgacttc gccggcacgt cggcggtggc gcgcgacgcg
     3241 gacggtgtgc ccgtcggctt cgtcaccggg tacgtccggc ccgagcgtcc gggcaccctg
     3301 ctcgtgtggc aggtggccgt cgacgccgcc caccgcggac gcggactggc cgcggccctg
     3361 ctcgacgggc tgaccgcgcg ggtcgcggaa cagcggacga tcaccgccgt cgagaccacg
     3421 atcacgcccg gcaacaccgc ctccgagcgc cttttcacct cgtacgcgcg acgccacggc
     3481 gcgcgcgtcg agcacgaagt gctgttcgag gccgggcagt tcccggacgg accgcacgac
     3541 cccgaagtgc tctaccggat cggtccgctc cccggctgac cccgcgccgg cccccggccg
     3601 acccggacac cccctggctt ccccctgcct tctccccctc cccccacgca ccgaggagcg
     3661 attcgccgtg accatcatcc agcccgacct gagcgtcttc gagaccctgg agtcggaggt
     3721 gcgcagctac tgccgcagct ggcccaccgt cttcgaccgg gctcggggca gccggatgtt
     3781 cgacgaggac gggcacgagt acctcgactt cttcgccggc gcggggtccc tcaactacgg
     3841 gcacaacaac cctgtactca aacgggccct catcgactac ctggagcgcg acggcgtcac
     3901 ccacggtctc gacatgtcga cgaccgccaa gcgcgccttc ctggaggcct tccagaatct
     3961 cgtcctacgg ccgcgcgacc tgccgtacaa ggtcatgttc ccggggccga caggcaccaa
     4021 cgccgtcgag tccgcgctga agctggcgcg gaaggtgaag gggcgcgagg cgatcgtgtc
     4081 cttcaccaac gccttccacg ggatgtcgct gggctcgctg gccgtgaccg ggaacgcctt
     4141 caagcgggcc ggtgccggga ttccgctcgt gcacgggacc ccgatgccgt tcgaccacta
     4201 cttcgacggc caggtgccgg acttcctctg gttcgagcgg ctgctcgagg accaggggtc
     4261 ggggctcaac cagcccgccg cggtcatcgt cgagaccgtg cagggcgagg gcggcatcaa
     4321 cgtcgcccgg cccgagtggc tgcgcgccct cgccgacctg tgccggcggc gcgacatgct
     4381 gctcatcgtc gacgacattc agatgggctg cgggcggacg ggagcgttct tctccttcga
     4441 ggaggcgggg atcgtgcccg acatcgtgac cgtgtccaag tccatcagcg ggtacgggct
     4501 gcccatgtcc ctgtgcctgt tcaagcccga actggacgtc tgggagccgg gcgagcacaa
     4561 cggcacgttc cgcggcaaca accccgcgtt cgtcaccgcc gccgcggccc tggagacgta
     4621 ctggtccgac gggtccgcca tggagaagca gacccgtgcc cgcggggagc agatcgagca
     4681 ggccctgatc tccgtcaccg aggagaacct cgccgacgtg aaggagtacc ggggacgcgg
     4741 tctcgtctgg ggcctcgagt tccacgagaa ggagcgtgcg gggcgcgtcg cgcagcgcgc
     4801 cttcgaactc gggctgctca tcgagacctc aggcccggag agcgaggtcg tgaaactcct
     4861 ccccgcgctc accatcaccc ccgacgagct cgacgagggc ctgcgcaccg tcgcccgcgc
     4921 cgtacgcgaa accgtctgac cgacgtccac agacgtccgg cagacatctg acagatctga
     4981 cagaaaggca cggcaccacc gtgatagtcc gttcgttcaa ggacatcgag ggcaccgacc
     5041 ggcatgtgaa ggccgcgacg ggtacctggg agagcaagcg catcgtcctc gccaaggaga
     5101 aggtgggctt ctccctccac gagacggtcc tgtacgcggg tacggagacg tccatgtggt
     5161 acgcgaacca catcgaggcc gtgctctgcg tggcgggcga ggccgagctg accaacgacg
     5221 agaccggtga gacgcactgg atcacgccgg gcacgatgta cctgctcgac ggccacgagc
     5281 gccacaccat gcgccccaag accgacttcc ggtgcgtctg cgtcttcaat ccgcccgtca
     5341 cgggacggga ggaccacgac gagaacggcg tctacccgct gctcaccgaa cccgaggagg
     5401 tctgaagccc catgaccacg accaccacga ccagcacgac caccgtcacc gatctctacc
     5461 ccagccgcgg cgccaccgag gtgtccgtcc cccgccagga cccggtcgtc tggggcacgc
     5521 ccggcacgcc ggggccgttc tccgtgcccg acctccaggc gtacgagcgt gacggcttcc
     5581 tcgcgatcga ggagctgatc ggcgaggacg acgtcgccct ctaccgggcc gagttggagc
     5641 ggctggtcac cgatccggcg atccgcgccg acgagcgctc gatcgtcgag cccgccactc
     5701 aggagatcag gtccgtcttc gaggtgcacc ggatcagcga ggtcttcgcc gcgctcgtac
     5761 gcgacgagcg ggtcgtcggg cgggcccggc agatcctcgg ctcggacgtc tacgtccacc
     5821 agtcgcggat caacgtcaag ccgggcttcg gggccagcgg gttctactgg cactcggact
     5881 tcgagacctg gcacgccgag gacgggctgg cgaacatgcg gaccgtgtcc gtgtcgatcg
     5941 cgctgaccga gaaccacgac accaacggcg gcctcatgat catgccgggg tcgcacaaga
     6001 cgttcctcgg ctgtgcgggg gccaccccgc gggacaacta caagaagtcg ctccagatgc
     6061 aggacgcggg caccccgtcc gacgaggcgc tgacccgctt cgccgaccgg cacggcatca
     6121 agctcttcac gggccgggcc ggttcggcga cctggttcga ctgcaactgc atgcacggct
     6181 ccggggacaa catcaccccg ttcccgcgca gcaacgtctt catcgtgttc aacagcgtgg
     6241 agaacgcggc ggtggagccg ttcgcggcgc cggtccgcag gcccgagttc atcggcgccc
     6301 gtgatttcac gcccgtgcag tgaccgcgag cgtgacgtgg ccgcacgcgt gacgtggccg
     6361 cgggcgtgaa ggagcagccc cccgccgggg tcagccggac aggacgtcca gcagtcggtc
     6421 gacgtcggcg ggggtgttgt acaggtggaa ggccgcgcgc aggttgcccg cccggtcgga
     6481 cacctcgacc ccggcctcgc tcagctcctg ctgccgccgg ccgagtccgg gcacggacac
     6541 gatcggcgag ccgggggcgg aaaccggcgt ctggccgagt ccctggagcc cggcgcggaa
     6601 acggtcggcg agggcgaggt cgtgggcgcg tacgttcgcc acgcccagct cctcgaagag
     6661 ctccagcgag tgccgggcgc ccgcgtacga gaagaggctg gggctctcgt cgaaccgccg
     6721 cgccgagtgg gcgagttccg ccaccgggcc gtagcagctg tcccagggcg cctcacccgc
     6781 gacccagccg gcgaacacgg gagtcagccc gccgaggtcc tccggaacga ccaggaaggc
     6841 cacgccccga gggcagacga gccacttgaa ggcgaccgag gagacgaagt cgtacgcgtc
     6901 ggcctggatc ggcagccagc cggcggcctg ggagacgtcg acgtacgtac gcgccccgtg
     6961 ctcgcgcgcg gcccgggcga tgcccgccag atcggcgatc cgcccgtccg cggactgcgc
     7021 ggcgctgacc gcgacgagcg cggtgcccgg acgtacggac tcggcgatcc gctccagcgg
     7081 tacggcgcgc agcttgaggt cgccacggac gtggaagggg ttcacgacgg agctgaagtc
     7141 gtcctccgcg gtgaggactt cggcgcccgg cggcagcgag gcggcgatca gtccgctgta
     7201 gacggcgacc gaggccccgg ccgccacccg gcccgcgggg accccggcca gccgggcgaa
     7261 ggcggcgcgg gcggcctcca cgtcgtcgaa catgtcggac ggccgtccgt cggcgacgga
     7321 ctcgacggcg acgcgcatgg cctcgaccgt gcgcgccggc aggagtccgc agctcgcggt
     7381 gttcagatag gtgttcttcg gggcgaactc ggctcgtacg aggctctcga aggtctccat
     7441 gggaccactg tgcggccccg agcacctctc gtccattacg gaattttgcg tggttccggt
     7501 aaggactgct tatacgtccg ccccgacctg cgctttcacc accgtgccgg acgggcttac
     7561 ggctgcggta cggcgcatcc gtccgggccg caggcctccg cgtcggcggc accgtcctgg
     7621 atcagcttca gcggcgggcg ttcgccccac gcctgggtca gggcctgcgc gaagacctcg
     7681 gcgggctggg cgccggagac accgtacttg cggtccagga cgaagaacgg cacgccgttc
     7741 gcgccgagct cggcggcctc gcgctcgtcg gcgcgcacct cgtcggcgta cgccttcggg
     7801 tcggccagca cctcgcggga cgcgtcggcg tcgagcccgg cggcgacggc cagctcgacg
     7861 agccgctcgt cgtcgttgaa gacggtccgc tcctcggcga agttcgcctt gtacagcagg
     7921 ccgatcagtt cgtcctggcg gccccgctcc ttggcgaagt ggaggaggcg gtgcatgtcg
     7981 aaggtgttgc cgtggtcgcg gtcccgggtg cggtaggcca ggccctcggc ggcggcctgg
     8041 gcgcccaggt tctcctcgcc ggcctgcgcc tgtgcctcgc tcatgccgta cttcttggtc
     8101 agcatcttga gcacgggctg gatgtcgccc ttggcgcgac cggggtccag ctcgaaggag
     8161 cggtgcacga cctcgacctc gtcacggtgc gggaaggcgt ccagcgcctt ctcgaagcgg
     8221 gccttgccca cgtagcacca gggacaggcg atatccgacc agatctcgac gcgcatgtct
     8281 tcggctctct ccaggtcgta cgaatacggg cccctccggg ggcaggagta tgtgaacgtt
     8341 caaacggccg gtttcattcc ccggtgacgg cgtagcgcag gaagaggtgg tgatcgcctt
     8401 cggcgggcgg gttctccggg tccgggaccc agccctggcg ggcgtagaag gcctgggcgc
     8461 gggcgttgtc gacgtgcacg tcgagagtgg cggtgtgctt gccgtcggcc cgccactgtt
     8521 cgagacaggc cgagtgcagt gcccggccga tgccctggcg ccagcagtcg ggatcgacgt
     8581 ggaactggaa gagcttcacg gtgtcggcgg gcgcgtcgtc ggccgtccgg aaggaggcga
     8641 tgcccaccag gtgtccgtca cgcaccgcgc agaggacatg ggcctcgggg cgctcgatgc
     8701 tgccccgcca cgcggcgacc cagtccacgt cgccgaaggg caggccgtcc gggtagtacg
     8761 tggagcgggc gcggaggtgc agctcggtga tggcggcggc ctcgctgggc agggcggttc
     8821 tgatgacgag ggggcccgtg gtgccgggtg tgctgatcat gcagcggagg acgtggtgga
     8881 ggggggccac ggttcccacc ccgcggccga ccccccaccc acggtcagct gccgtctctc
     8941 aggtccttgg gccagttcgg gcggaactcg atgccgtcgt acgtcaccac gcacccctcc
     9001 cccatcggcg actgcgtcat gaagccgacg agcgcggcgg acgtctcctt ctcctcaccc
     9061 agggtgaaga gccggatgaa cgtccagcgc ttgccgtcgc gggaggcgtg gaaggcgaag
     9121 gcccgacccg tgcggctgat ccgcagccag acggaactgc cgtccacggt gaaggagttg
     9181 gcgtcgtcgg agtgcccccg ggtgaccacc gtgcagacgg tgggcacgtc cggggagtac
     9241 tccaggcaga gcttcgccca ggcccgctcc cccacatgga cgtagaggac ccccgcgtcg
     9301 aaggccgcgc cgaagccgac cgtgacgcgg gcgatcagct ggaagtcccc ctccggcgcc
     9361 ccgaggagac ggggcgcgtc ggaggccggg tccagtgcct cgtcggtggg cggtacgaaa
     9421 cggtcctggc gggggccggc ccagccggtg agtatcccgt cctcgtgcga ccagtgcccg
     9481 tcaggcccgt aggtacggag ggggaaggga agttcgggaa gttcgacgtc cattcaccca
     9541 tactctcagg ccaagtaccg cgcccccgaa ggggcgcggg gaactgcgcg accagccaca
     9601 acggccccgc agcccgcgaa cgaccacaac cccgacggcg ctacccgcgg agcgctaccg
     9661 ctccaggtga ccgtcgtagc gtcgcggcag ccccagcggg ttgtcgtccc gcagctccgg
     9721 cggcagcagc gcctccggcg cgttctggta cgccaccggc cgcagccagc gctcgatcgc
     9781 cgtaccgccg accgacgtcg aggtcgacgt cgtcgccggg tagggaccgc cgtggtgctg
     9841 ggcgggggcg acggcgacac cggtgggcca gccgttgacc aggacgcgcc cggcgagcgg
     9901 cgtcagctcg gcgaggatct ccgcgccgcg gccttcgccc gccgcctcct ccgtcgacaa
     9961 ctgcacggtg gcggtgaggt tgccgggaag gcgcgagagg accgcgctgg cctcggactc
    10021 gtcctcgtag cgggcgacga ccgtgagcgg gccgaagcac tcctccagga gcaggtcgtg
    10081 ctcaccctcg gtgacgagct tctgcgcggg cacggtcagg aagccggggc tcaccgtgtg
    10141 ctcgccgccc gagcccgggg tcaccgggga ctcgacgccg gggagcccgg cgcgctcggc
    10201 gacacccgcg atgaagttgt cgcgcatgcg gtggtccagg agaacgcccg cgtcggtgtc
    10261 gctgacggcg tcggtcaggg acttcaccag gcggtcgccc gccgcgcccg cgggcgccag
    10321 gaccaggccc ggcttcacgc agaactggcc gacgcccagc gtcatcgagc ccgcgagccc
    10381 ggcgccgatc gcctcggcgc gctcg
//
