LOCUS       NZ_CP041610            10858 bp    DNA     linear   CON 14-NOV-2023
DEFINITION  Streptomyces sp. RLB3-17 chromosome, complete genome.
ACCESSION   NZ_CP041610
VERSION     NZ_CP041610.2
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RLB3-17
  ORGANISM  Streptomyces sp. RLB3-17
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Massive gene flux drive genome diversity within a population of
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 12022941)
  AUTHORS   Tidjani,A.-R., Lorenzi,J.-N., Toussaint,M., Van Dijk,E., Naquin,D.,
            Lespinet,O., Bontemps,C. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66.0x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/14/2023 04:19:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,027
            CDSs (total)                      :: 10,924
            Genes (coding)                    :: 10,421
            CDSs (with protein)               :: 10,421
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 503
            CDSs (without protein)            :: 503
            Pseudo Genes (ambiguous residues) :: 0 of 503
            Pseudo Genes (frameshifted)       :: 178 of 503
            Pseudo Genes (incomplete)         :: 409 of 503
            Pseudo Genes (internal stop)      :: 52 of 503
            Pseudo Genes (multiple problems)  :: 128 of 503
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 458308
            Orig. end                         :: 469166
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041610.2.
            On Mar 4, 2020 this sequence version replaced NZ_CP041610.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10858
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10858
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10858
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5858](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5858
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            complement(<847..>1038)
                     /locus_tag="FNV62_RS55215"
                     /old_locus_tag="FNV62_02380"
                     /pseudo=""
     CDS             complement(<847..1038)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268373.1"
                     /locus_tag="FNV62_RS55215"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="FNV62_02380"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MANSQLVIDGDSRRLVVVSGPFPGNRAACKAWEEPGAKAAVGNTT
                     TSADGGYPGTGIVMPHRRD"
     gene            complement(1106..1585)
                     /locus_tag="FNV62_RS02325"
                     /old_locus_tag="FNV62_02385"
     CDS             complement(1106..1585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073617.1"
                     /locus_tag="FNV62_RS02325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02385"
                     /product="DUF6194 family protein"
                     /protein_id="WP_144316388.1"
                     /transl_table=11
                     /translation="MEQIIATVRGFVGALVVVPEQGGDFPELVWGDAFFYYAPDGGVPA
                     NVQPYGTIVTKNYPDDAVSDLDSPGRWRLNIHVDRATFRELTGEEPRSLTRPRDYAAAD
                     SVMPHPVYGALGWVSVVNPGERTTETAVQLLRSAHDAARARCARRHATQGSQEND"
     misc_feature    1570..1584
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.51"
                     /tool="antismash"
     gene            1633..2370
                     /locus_tag="FNV62_RS02330"
                     /old_locus_tag="FNV62_02390"
     CDS             1633..2370
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554342.1"
                     /locus_tag="FNV62_RS02330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02390"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_144314554.1"
                     /transl_table=11
                     /translation="MGELVSGSRRGPLRTVDVAGESGYSVQQVRDLERLGVIPPAARSS
                     NGYRSYTPLHVHALRAYRGLAGAVGPVTARHMLAELRTETIAEAASAISAVHVRLARER
                     EEALRAQQALRAIQAEANTPEFEQESDAMTITQLAGALNVRPSTLRFWEQEGLVTPERV
                     TSLQARRYDLSAIRAARIVAALRGTGYGIPAVRQIMGSLHQLDSLDKTQRILQQRLDQI
                     ATRTVALLRAGADLAAVVGDHGS"
     gene            complement(2715..4223)
                     /locus_tag="FNV62_RS02335"
                     /old_locus_tag="FNV62_02400"
     CDS             complement(2715..4223)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385836.1"
                     /locus_tag="FNV62_RS02335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02400"
                     /product="cytochrome P450"
                     /protein_id="WP_318658451.1"
                     /sec_met_domain="p450 (E-value: 1.6e-13, bitscore: 49.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARQQEQQGRFNERGLQEQQEQHELRGGGGGVVDLRAVPNGPDQE
                     DVPDAQGVPDLRAGRGGCPYVMDGLGRDVQGEGALLRGQGEAVRVVLPGGVGAWAVTDP
                     AVIRGLLTDGRVSKDAYRHWPAWQRGEVGAEWPLAVWVSVQNLVTSYGAEHRRLRGLMG
                     SAFTARRVGLLGPRVGEIAAGLLEGMEAAAREARGGVVDVRGLYAQPLPSRVMLELFGI
                     PEEFRGALREIIEGFFATGVSLEDARRNYAALYRTMGELVAFKRRRPGEDLTSALIAAG
                     SGADPADPAAASDLTDVAGGVGAGGPEAPGGGGLSEKELVDNLIMLLSAGCEPTVNLLA
                     NAVVLLLREPGQLELVRSGRASWGDVVEEALRVEAPGANAILRYAVEDVRVGETVIPRG
                     DALVIGFAAAGRDPGVHGEDAERFDVMRATRREHLSFGHGVHYCLGAPLARLEAEIALQ
                     ALFDRFPGMRLAVEPGALLPTESFISNGPREVPVLLGPSADGVR"
     misc_feature    4633..4649
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            5001..5858
                     /locus_tag="FNV62_RS02340"
                     /old_locus_tag="FNV62_02405"
     CDS             5001..5858
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015700.3"
                     /locus_tag="FNV62_RS02340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02405"
                     /product="AfsA-related hotdog domain-containing protein"
                     /protein_id="WP_144314556.1"
                     /sec_met_domain="AfsA (E-value: 5.6e-24, bitscore: 83.3,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLTVHQDNHPTPATTATGTGTATGPHPAAEPDPTTRTSTETKT
                     GTGTSAKTPVDPARMPRLTTTVPREYVHRSTLAEVFLTGCEQTGNTHYTLTAQWPRAHT
                     FFTTPDGTHHHPLQAAETIRQTGIYLAHAELGIPLGHHFLMRNLHLTTHPQHLTIGPTP
                     HRPFTLTATYTPTTPTPNAPPDFTMHITITRNGHPTATGTGRFTCLTPTTYQRLRHPHT
                     HHTRHHHSSHHHQPTSTPPPTPPTPPTHPLRTHPPPRHRPHPHPKPPTHLATHPQPPPP
                     HIPF"
     gene            complement(6422..7225)
                     /locus_tag="FNV62_RS02345"
                     /old_locus_tag="FNV62_02410"
     CDS             complement(6422..7225)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983612.1"
                     /locus_tag="FNV62_RS02345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02410"
                     /product="VOC family protein"
                     /protein_id="WP_143599721.1"
                     /transl_table=11
                     /translation="MKSDAALHGEVTASHSVFGAPCWASLTTRDLRAAEDFYRAVMGWE
                     WRTSSTVGDQYRVASVHGVPVAGVSEVNFGVNTAVAWTPYFAVASADETVSRSQERGGT
                     TAVGPISFPPGRAALLADRDGAVFGIWEGELVAGWEEWRRAAPVFVRLHTRDAFDAAIF
                     YAEVLEWASSDPRSCEVRYEDNEVVLRSRGDVVARIHSGAVEAAPDPTIRPHWQIHFTV
                     DDVEAAARAARAHGGTAHQQGLGSTEAILTDPDGARFFVTTRRTD"
     gene            complement(7547..7720)
                     /locus_tag="FNV62_RS02350"
                     /old_locus_tag="FNV62_02415"
     CDS             complement(7547..7720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948441.1"
                     /locus_tag="FNV62_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02415"
                     /product="CsbD family protein"
                     /protein_id="WP_079089342.1"
                     /transl_table=11
                     /translation="MSKAKAKAKQVKGKMKETTGKAMDDESMQVEGRGEQIAGKAQETA
                     DKAAGRVKRTGR"
     misc_feature    complement(8435..8450)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            8560..9192
                     /locus_tag="FNV62_RS02355"
                     /old_locus_tag="FNV62_02420"
     CDS             8560..9192
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940653.1"
                     /locus_tag="FNV62_RS02355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02420"
                     /product="DUF4360 domain-containing protein"
                     /protein_id="WP_143654116.1"
                     /transl_table=11
                     /translation="MVLRALAATGVAASLFGSSSFGGTPPPPSGRIVIDTVAVNGSGCP
                     AGAAAVTVSPDNTAFTVTYSNYLARVGPGSAPTDRKKDCRLNLRVHVPGGYTYAIVSAG
                     FSGFASLALGASGTQRASYHFQGNAHTTNSTHHFEGGFNGNWQTTDTVDVAARVFAPCG
                     EERNLDINTELRVERGTSSPSATSFIEMDSTDGRIKTVYHMAWKRCR"
     gene            complement(<9295..10003)
                     /locus_tag="FNV62_RS02360"
                     /old_locus_tag="FNV62_02425"
                     /pseudo=""
     CDS             complement(<9295..10003)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="FNV62_RS02360"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="FNV62_02425"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRLVTGVRRPEKTCHGPTRPQGGGRRRCGDREVLAAFIFVATTGC
                     TWRQLPPVFGPSGPTAHRRFTEWTGARVWAKQHRLVLDELGARGDLDCSRCAIDSVNLR
                     ALKGGR"
     misc_feature    complement(9344..9346)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10052..10312)
                     /locus_tag="FNV62_RS02365"
                     /old_locus_tag="FNV62_02430"
     CDS             complement(10052..10312)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979487.1"
                     /locus_tag="FNV62_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FNV62_02430"
                     /product="hypothetical protein"
                     /protein_id="WP_143599724.1"
                     /transl_table=11
                     /translation="MSERRPEAPGTSGKPIPKPVPRDPPDQQATADVDPWDALGVPTQS
                     TAEEQPDLEIPDTDEAGTGRRGAPHSGSRRPEHPVPDEPPA"
     misc_feature    complement(10301..10312)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(10507..10525)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.96"
                     /tool="antismash"
     misc_feature    complement(10717..10732)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.75"
                     /tool="antismash"
ORIGIN
        1 acccggagcc gatcggcacc ggcgcctccg gccacctgcc ctcccacccg cacggctaca
       61 cccggccccg ctacagccgg ttcctcggag cgctggtcga acacctcggc gtccccgacg
      121 tgttcctgct gggccactcg cacggcggct tcgtcgctca gtaccacgcc ctgcaccacc
      181 ccgagcgcat cgccggggtg atcctctacg agagcgcgcc gctgaccggt cccgaacacg
      241 gcgccgaggc cacgcgcctg gtgcagtcgt tcgccgcgct ccacgccgac caccccgaac
      301 tccccgaggt cctggccgcg ttccaggcga tccccaccat ctccgacgac gcacagatga
      361 cagccgtcgc cagaggggtg ctccccgcgt acttcgccga ctactggggg cgcgaggggg
      421 agttcgctcc catgcgtgcc tcggtgcggg ccgcacacat ctccgggctg gacgagaacc
      481 tctccccgca tgtcatcgac gaccgtgcgg acctcggctc actcaccgtg ccgaccctcg
      541 tcgtcgtcgg ccgccacgac gtcgtctgcg gggtgcgatg ggccgaggaa ctgcacctgc
      601 tgatccccgg atcggagctg ctggtcctgg agaacagcgg gcacttcggt cacctcgagg
      661 agccggaggc cgtctcgcag gcggtgacac gtttcgtgaa ggccgtgaac tcacctacca
      721 gctaagccat ttgagcgaag ccgcaacgga cggtccagcg tgaggctcgt cccgcgatga
      781 tcctggaatc aacgtggacg agaaggggcg ctgtgtgagc cgcttcgtcc atccggcgag
      841 ggcgaggtcg cgccggtggg gcatcacaat gccggtgccc gggtagccgc cgtcggcgct
      901 cgtagtggtg ttgccgacgg cggccttggc tccgggctct tcccacgcct tgcatgcggc
      961 acgattgcct ggaaacgggc cgctgaccac gacgagccgg cggctgtcgc cgtcgatgac
     1021 gagctgggaa ttggcggagc tggagcgaac tcgcgctcac cgcggtgtgc ggggcaccct
     1081 caagtacgct tgctccggaa ccgtgtcagt cgttctcctg cgacccttgc gttgcgtgtc
     1141 gccgcgcgca ccgcgcacga gcggcgtcgt gggcgctgcg caaaagctgc acggccgtct
     1201 ccgtcgtcct ctcaccggga ttgacgacag agacccagcc gagtgccccg tataccgggt
     1261 gcggcatcac gctgtcggcc gccgcgtagt cgcgaggtcg ggtgaggctg cgcggctcct
     1321 ccccagtgag ctctcggaac gtcgcacggt cgacgtgaat gttcaggcgc cagcggcccg
     1381 gagagtcaag gtcggacacg gcgtcgtcag ggtagttctt ggtgacgatg gtcccgtagg
     1441 gctggacgtt cgcaggtacc ccaccgtcgg gggcgtagta gaagaacgca tctccccaca
     1501 cgagctccgg gaaatcgccg ccctgctccg ggacaaccac gagcgcgccg acgaagcctc
     1561 gcacggtcgc gatgatctgt tccatactca tggttcaagc atcaccttca agtgcttatg
     1621 tggggttggc tgatgggcga gctggtgagc ggttctcgac ggggaccgct ccgaaccgtc
     1681 gatgtcgccg gagagtcggg gtactcggtg caacaggttc gcgacctgga acgtctggga
     1741 gtcattcccc cagccgctcg atcgagcaac ggataccgtt cctacacacc gctgcacgtg
     1801 catgccctac gcgcctatcg aggactcgca ggtgctgttg ggccagtcac agcccggcac
     1861 atgctcgcgg aactgcgtac ggagacgatc gcggaggcgg cctcggcgat cagcgcggtc
     1921 catgttcggc tcgcgcggga acgagaggag gccctgcgcg ctcaacaagc gttgcgtgcg
     1981 atccaagccg aggcgaacac tcccgagttc gagcaggaga gtgacgcaat gacgatcaca
     2041 cagctcgctg gagcgctcaa tgtacgtccc tccactctgc ggttctggga gcaggaaggg
     2101 cttgtcacgc ccgagcgagt gacgtcactg caagcacgcc gctacgatct ttcagccatc
     2161 agagcggccc gaatcgtcgc ggccctgcgc ggcaccggtt acggcattcc cgcagtgcgc
     2221 cagatcatgg gctccctgca ccaactcgac agcctggaca agacccaacg catcctgcaa
     2281 caacgccttg accagatcgc cacacggacc gtggccctac tccgagcggg tgcagacctg
     2341 gcagccgtcg ttggcgacca tggctcgtag tggctggtcg tcagcgcggc gactacgcca
     2401 gatgatggag cgccggatca tgctgccttg ctcttcgtgt ccggcgtgat cggtgccgtc
     2461 gagagtgaag tcgcgcaggg cggtgaagga gagtagctgt cgcacacgac cgtcgggcgg
     2521 atcgtcgctg agtggatggt gcatgggtag cggcaaggtg tcggcagttc atgcgggccg
     2581 catgtatcgc ctggtcgtgc cgagagatcg gcagatgccc ttcgaggccc tgttgctcgt
     2641 cgccgggagc ccgtgcacgt ctgcccaggg gccatccgcc ccgagcctgt tcaaacaggg
     2701 tgcaggccgg cgcgtcacct caccccgtcg gccgacggcc ccagcaacac cggcacctcc
     2761 cgcggcccgt tcgaaatgaa cgactccgtc ggaagcagcg cacccggctc caccgccagc
     2821 cgcatcccgg gaaagcggtc gaacaacgcc tgaagggcaa tctcggcctc cagccgcgcc
     2881 aacggcgcgc ccaggcagta gtgcacccca tggccgaacg acaaatgctc ccgccgcgtc
     2941 gcccgcatca catcgaaccg ctccgcatcc tccccgtgca cccccggatc ccgcccagcc
     3001 gccgcgaacc cgatcaccag cgcatccccc cgcgggatca ccgtctcccc cacccgcacg
     3061 tcctccaccg cataccgcaa aatcgcattc gcccccggcg cctccacccg caacgcctcc
     3121 tccaccacgt ccccccacga cgcccgcccc gaccgcacca actccaactg ccccggctcc
     3181 cgcagcaaca acaccaccgc gttcgccagc aggttcaccg tcggctcaca ccccgcgctc
     3241 aacaacatga tcaagttgtc caccaactcc ttctcactca accccccacc ccccggggcc
     3301 tccgggccac ccgcgcccac accgcccgcg acgtctgtga ggtccgaagc ggccgcggga
     3361 tcggcgggat ccgctccact ccccgcagcg atcagcgcac tcgtcaggtc ctcacctgga
     3421 cgacgccgct tgaacgccac caactccccc atcgtccgat acagcgccgc gtagttgcgc
     3481 cgcgcatcct ccaacgacac ccccgtagcg aaaaacccct caatgatctc ccgcaacgcc
     3541 ccccggaact cctccggaat cccgaacaac tccagcatca cccggctcgg caacggctgc
     3601 gcatacaacc cccgcacgtc caccacaccg ccccgagcct cccgcgccgc cgcctccatc
     3661 ccttccagca gccctgccgc gatctccccc acccgcggac ccaacaaccc cacccgccgc
     3721 gcagtgaatg ccgatcccat caacccccgc agccggcgat gctccgcccc gtacgacgtc
     3781 accagattct gcaccgacac ccacaccgcc aggggccact ccgcccccac ctcaccccgc
     3841 tgccatgccg gccaatgccg atacgcgtcc ttcgagaccc gaccatccgt caacaaccca
     3901 cggatcaccg ccggatccgt caccgcccag gctcccaccc cacccggcaa caccacccgc
     3961 accgcctcac cctgcccccg cagcaacgcc ccctccccct gcacatcccg ccccaaccca
     4021 tccatcacat acgggcaccc accccgccca gcacgcagat ccggcacgcc ctgcgcatcc
     4081 ggcacatcct cttggtccgg cccgttcggc acggcacgca ggtccaccac gccaccgccg
     4141 ccgccccgca actcgtgttg ctcctgctgc tcctgcaggc cccgctcatt gaaccgaccc
     4201 tgctgctcct gctgacgcgc caccggacac ctccacgaca tagaccgcga aaacttcccg
     4261 acaagcacta cacacacccc gacaccacgc ccgcaccatc acccggacgc ccaccagggg
     4321 cacaaccccg cacacacgcc aggccccgcc ccggagaacc gccccggagt cccgccatca
     4381 gccatggacc cccgacaccc gatccccgtg cgggcagcag cccgcggccc gcaggaaccc
     4441 aacccctggg cacacgcccg ggaccgggtc ccggatgcac acccggacct caccaccagc
     4501 aatcgcccag ccccacaccc ggcacaccct ggcacgcacc ctgggtgccg gtcacaggcc
     4561 gtgtgcgtcc gggtgccgac cccgggccat gcgcatcccg gaagccatcc ccccgacagc
     4621 acccacaccc gccagagaac cactcgcaaa acaaaaccgc tcggccggtt tcactatagc
     4681 ctcacccgag acccacacaa gagaccccag cacaccccca caaccacccg accccgagcc
     4741 tcgcacacca cccccaaccc cggaagacac ccgcagaacg gaatcaaaac caccgcttat
     4801 ccagcgaaga tccccaccac acacccacag cgaaccaatg aatatgcacc ccgcacaccc
     4861 cccacccgac ccccggacca acccccggcc tgcccccgcg aaaatccccg cccacccttg
     4921 aaaagaaaac cggtaggttc gtatcttatg accctgcacg gtccatcccg gcacctccca
     4981 cagcgccacg ggagacccac atgaccctgc tcaccgtcca ccaggacaac caccccaccc
     5041 ccgccaccac ggcaacagga acgggaacgg caacaggccc ccacccggca gcagaaccag
     5101 accccaccac gcggaccagc acggaaacaa aaacaggcac cggcaccagc gcaaaaacac
     5161 ccgtcgaccc cgcccgcatg ccccgcctca ccaccaccgt cccccgcgaa tacgtccacc
     5221 gctccaccct cgccgaggtc ttcctcaccg gctgcgaaca gaccggcaac acccactaca
     5281 ccctcaccgc ccaatggccc cgcgcccaca ccttcttcac cacccccgac ggcacccacc
     5341 accaccccct ccaagccgca gaaaccatcc gccaaaccgg catctacctc gcccacgccg
     5401 aactcggcat ccccctcggc caccacttcc tcatgcgcaa cctccacctc accacccacc
     5461 cccaacacct caccatcggc cccacccccc accgaccctt caccctcacc gccacctaca
     5521 cccccaccac ccccacacca aacgccccac ccgacttcac catgcacatc accatcaccc
     5581 gaaacggcca ccccaccgcc accggcaccg gccgcttcac ctgcctcacc cccaccacct
     5641 accaacgcct ccgccacccc cacacccacc acaccagaca ccaccacagc agccaccacc
     5701 accagcccac cagcaccccc ccaccaaccc ccccaacccc ccccacccac ccactacgga
     5761 cgcaccctcc tccacgacat cgtccccacc cccaccccaa accccccaca cacctggcaa
     5821 ctcaccccca acccccacca ccccatatac ccttctgacc acaccaccga ccacatcccc
     5881 ggcatggtcc cccccccgaa gccgcccacc aagccgccac cgcccacacc caccccaccc
     5941 ccacccccac aacccacccc acccacccca ccaccctcca cgccaccttc caccactaca
     6001 ccgaacacca cacccccacc tacatcacca cccacaccac caccaacgac aacaaccaaa
     6061 cccccaccac ccacatcacc gcacaccaaa acaacaccac cgtcttcacc gcacaactca
     6121 ccacccacac ccccacccac acctgagaaa cttctaacga gacaggagct cagcttcggt
     6181 tcgggcatgg tcggagtccg gtgtggctca actggccgaa catgttgctt gtacagatgc
     6241 tcacgcggcg ccgatggact gctgaggcaa tgcgcaactt cctgcgtcat gccacgaccg
     6301 cgagccggcc gcgctcgtga cccggcaccc ggaggtcacc gaacggcacg tcgccgacca
     6361 ggccctcaag ttggagaccg ttcggcacat cctggaccgg gcagcactga cgctgcggcc
     6421 ctcagtccgt ccttcgcgtg gtcacaaaga agcgggctcc gtcggggtcg gtgaggatgg
     6481 cctcggtcga gccgaggccc tgctggtggg ccgtgccgcc gtgggcgcgg gcggcgcggg
     6541 cggcggcctc gacgtcgtcg acggtgaagt ggatctgcca gtgcggccgg atcgtcgggt
     6601 cgggcgcggc ctcgaccgcg ccggagtgga tacgggccac gacgtcgccc cggctgcgca
     6661 gcacgacctc gttgtcctcg tagcgcacct cgcaggaccg ggggtccgag gacgcccact
     6721 ccaggacctc cgcgtagaag atggcggcgt cgaaggcgtc gcgggtgtgc agccgtacga
     6781 agaccggtgc cgcccggcgc cactcctccc agccggccac cagctcgccc tcccagatgc
     6841 cgaacaccgc tccgtcccgg tcggccagca gcgccgcccg gcccggcggg aacgagatcg
     6901 gccccaccgc ggtcgtaccc ccacgctcct ggctacggga aaccgtctcg tccgcactcg
     6961 ccaccgcgaa atacggggtc cacgcgaccg ccgtgttcac cccgaaattc acctccgaaa
     7021 cccctgcgac cgggaccccg tgcacgctcg cgacgcggta ctggtcgccc accgtgctgc
     7081 tcgtgcgcca ctcccagccc atcacggcac ggtagaaatc ctccgccgcc cgcagatcgc
     7141 gcgtggtcag actcgcccag cagggtgccc cgaacaccga gtgactggcg gtgacctcac
     7201 cgtgcagtgc tgcgtcgctc ttcatcctcg taccgcctga cctacctgac accacagcca
     7261 tcaaggggcg ttgaactacc ccggacccag tgcccgccca aaagccgagt gccccttcga
     7321 acgcacggca acccgctgct ccgcgttcac cgcgcagcga ccgccgcgag acacgtcgca
     7381 ctctctgccg tggcgcgcaa cagaccgagg cggtcggggc tgtcccggcc gcctcgaatc
     7441 ggctcacgca gccaaaccgc aggtggtgcc gaccgtcgag atcttcggac tcggcattcg
     7501 ctcggctcgg tgcgtcccgt cgaatgtgtc gccggagcga gcagtcctac cggccggtcc
     7561 tcttcacacg gcccgcagcc ttgtccgcgg tctcctgcgc cttaccggcg atctgctcac
     7621 cacggccctc gacctgcatg ctctcgtcgt ccatggcctt gccagtggtc tctttcatct
     7681 ttcctttgac ctgcttggcc tttgccttcg ccttgctcat gatccgttgc cctccaatga
     7741 ggctcgaatt ggtgcttaaa ccatgcgctg ggcacgacgg ctccgcaacc gagccacaat
     7801 gcggccgcgc ggccgtgtcc gcgaaatgcg gcagcaccaa ggaatgccag aacgaaacag
     7861 atccagggcg cgatgaggga ggcccctcgg caaagtccgt gggttaccga tcatgcagct
     7921 gccaaggcgg cgagcagctt cgtggcatgg cccgagaggg acagggcgga ggcattctcg
     7981 ccctgcggat atgggtcacg tccgttggag tggtgtatcg acggccactc ggtgatctcg
     8041 ttttgacgct gtgcagtgag ttggacgtcg tctcaattgg tcctgcgaag agccgggcgt
     8101 ctcgggtgga gcgggcgctt cagcgcacgc acaatgcgac ctggaggacg ggccgcagtt
     8161 gcggaagaag cagcggcgca aggagtcccg gctcgatccc tacaagtcgc tgttcgacgg
     8221 catgttgcgg gctgactgga tgctcgtccc atacagcggc acaccaccca gcgcatctat
     8281 gagcgcctga tggagagcca ccggcttgtc accctcggcg cgccccctgg gtaatggcgg
     8341 tagagcagat tgagtgtgcc ggtgtatccg agctcgcgcg ccgctctgtt cccgtgagtg
     8401 gatgaacgag gcctccaccc tgaaggccgt tcgagtgact ggcgcgtcac cttccgtccg
     8461 cggacacgca acgtgtggtg cgatgccctc gtgaaatccg ggggccgggc tcggaaagtg
     8521 accccggccc tggatccgtg gacgattgaa gggaagccca tggtgctccg cgcgctggcc
     8581 gcgactggtg ttgccgcatc attgttcggc tcgtcgtcct tcggcggcac cccgcccccg
     8641 ccgtcgggcc ggatcgtcat cgacacggtg gcggtcaacg gttccggctg cccggcgggg
     8701 gcggccgccg tgaccgtgtc ccctgacaac accgccttca ccgtcaccta cagcaactac
     8761 ctcgcccggg tggggcccgg ctcggcgccg accgaccgga agaaggactg tcggctcaac
     8821 ctgcgagtgc acgtccccgg tggctacacc tacgcgatcg tgtccgccgg cttcagcggc
     8881 ttcgcgtcac tggcgctggg tgcgtccggg actcagcggg ccagctacca cttccagggc
     8941 aacgcccaca ccaccaactc gacccatcac ttcgagggcg ggttcaacgg caactggcag
     9001 acgaccgaca ctgtggacgt cgccgcccgg gtcttcgccc cctgcgggga ggagcgcaac
     9061 ctcgacatca acaccgaact gcgggtcgag cgcggcacct cgagcccgag cgccaccagc
     9121 ttcatcgaga tggactcaac ggacggcagg atcaaaaccg tgtaccacat ggcctggaag
     9181 cggtgccgat gatctcctgg cgctgcgatc ggcgggtgcg cccaggccaa cggctctcgt
     9241 catcggtggt agcactgtgt ggtgatcacc ggaggagaat gcgctggcgg agcagctgca
     9301 ggcaatggcg gtgaaggcca ggaagtgctc ggccttgcgt tcgtaacggc ggtgcaggcg
     9361 gcggcagccg cccagccagg acatcgtgcg ctcgatcgtc cggcggtgtc gggccagccg
     9421 cgtggaggac tcgatgccct tgcgggtgat gcggtggcgg atgccgcgct cacgaagcca
     9481 tcggcgcagg tggtcgtagt cgtagccctt gtcgccatgg agctcggcag ggcgtcggcg
     9541 gcgcgggcgc cgacgggagc cgatcggcgg gagcccctgc accagggctt ggagggcctg
     9601 gctgtcgtgg aggttggcgc cggagatgcc gatcgagagg ggcagaccct gtcgacagga
     9661 ttcggacctg tcagcgcccc cctttcaggg cccgcaggtt caccgagtcg atcgcgcagc
     9721 gcgagcagtc caagtccccg cgggcgccga gctcgtccag gaccaggcgg tgctgcttgg
     9781 cccacacgcg ggcgccggtc cactcggtga agcgccggtg tgcggtcggg cccgaggggc
     9841 cgaacacggg aggcagttgg cgccaggtgc agcccgtcgt ggccacgaag atgaacgcgg
     9901 ccaggacttc ccggtcgccg cagcgtcgcc ggccgccgcc ctgtggccgc gtcgggccat
     9961 gacatgtctt ctcgggccgc cggactcctg tcaccagtcg caggtatgtc tcccagcgtt
    10021 acctgccggg gctcccgcgg cacgcggagc gtcaggcggg cggttcgtcg gggacgggat
    10081 gctccggacg tcggctgccg gagtgcgggg cgcccctgcg gccggtgccg gcctcgtccg
    10141 tatcgggaat ctccaggtct ggctgctcct cggcggtgga ctgcgtcggg acgccgaggg
    10201 cgtcccaggg gtccacgtcg gcggtggcct gctgatcggg cggatccctg ggtaccggct
    10261 tcggtatcgg cttcccactg gtcccagggg cttccgggcg gcgttcactc acggtgttct
    10321 cgcttcctcg atcagggggg tggtgtgagt cgcaggtacc ccggcggccg acgatgatgc
    10381 cgatgatcga ggccccgccc cgaggctggt cggcggctgc gcggagggtt gatgagttcc
    10441 cccaccgtcg ctccgatcac agaaggggac acagcaaccg ccggaattcc gaacgatggt
    10501 gctgcgatgg agcgtcgatc gccatcgtcc aggcgtcaca actcgtcggc atcgtaaggt
    10561 gtcccctgtg aaactccagg agttgctcga caagcaagac tcctatggtg ccccggctgt
    10621 gttagcagga ctttccgcag ccaaggtacg aagtgtcgct actcgtgggg cagttcgggt
    10681 gagcccggac tcgtgctttc gcatcgcgtc gtagacaaag gtcttcacct gtaccgcgct
    10741 cgtgaagacc atgcgagaca actccatccc tctcggtaca gccgtcatcg agttgcttcc
    10801 tgacctcgca cctggctggc gagccgatgt gcgcctcgcc atcgagcaga tcctcggg
//
