LOCUS       NZ_CP041405            21863 bp    DNA     circular CON 07-APR-2024
DEFINITION  Paenibacillus thiaminolyticus strain NRRL B-4156 chromosome.
ACCESSION   NZ_CP041405
VERSION     NZ_CP041405.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6612542)
  AUTHORS   Hehnly,C. and Zhang,L.
  TITLE     Paenibacillus thiaminolyticus NRRL B-4156
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6612542)
  AUTHORS   Hehnly,C. and Zhang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2019) Institute of Personalized Medicine, Penn
            State College of Medicine, 500 University Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2018
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_Pthia_1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007066085.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 14:58:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,886
            CDSs (total)                      :: 5,776
            Genes (coding)                    :: 5,673
            CDSs (with protein)               :: 5,673
            Genes (RNA)                       :: 110
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 52 of 103
            Pseudo Genes (incomplete)         :: 68 of 103
            Pseudo Genes (internal stop)      :: 17 of 103
            Pseudo Genes (multiple problems)  :: 28 of 103
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:43:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5488883
            Orig. end                         :: 5510746
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041405.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Schiff/Broach Lab 500
            University Drive Hershey, PA 17033
            Chromosome not circularized.
FEATURES             Location/Qualifiers
     region          1..21863
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="15"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21863
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21863
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11863](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11863
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     rRNA            1029..1145
                     /db_xref="RFAM:RF00001"
                     /db_xref="GeneID:76999090"
                     /gene="rrf"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="FLT43_RS24335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="FLT43_24335"
                     /product="5S ribosomal RNA"
     gene            1029..1145
                     /db_xref="GeneID:76999090"
                     /gene="rrf"
                     /locus_tag="FLT43_RS24335"
                     /old_locus_tag="FLT43_24335"
     tRNA            1195..1270
                     /anticodon=(pos:5490111..5490113,aa:Asn,seq:gtt)
                     /db_xref="GeneID:76999091"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24340"
                     /product="tRNA-Asn"
     gene            1195..1270
                     /db_xref="GeneID:76999091"
                     /locus_tag="FLT43_RS24340"
                     /old_locus_tag="FLT43_24340"
     tRNA            1274..1365
                     /anticodon=(pos:5490192..5490194,aa:Ser,seq:gga)
                     /db_xref="GeneID:76999092"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24345"
                     /product="tRNA-Ser"
     gene            1274..1365
                     /db_xref="GeneID:76999092"
                     /locus_tag="FLT43_RS24345"
                     /old_locus_tag="FLT43_24345"
     tRNA            1370..1444
                     /anticodon=(pos:5490286..5490288,aa:Glu,seq:ttc)
                     /db_xref="GeneID:76999093"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24350"
                     /product="tRNA-Glu"
     gene            1370..1444
                     /db_xref="GeneID:76999093"
                     /locus_tag="FLT43_RS24350"
                     /old_locus_tag="FLT43_24350"
     tRNA            1457..1532
                     /anticodon=(pos:5490373..5490375,aa:Val,seq:gac)
                     /db_xref="GeneID:76999094"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24355"
                     /product="tRNA-Val"
     gene            1457..1532
                     /db_xref="GeneID:76999094"
                     /locus_tag="FLT43_RS24355"
                     /old_locus_tag="FLT43_24355"
     tRNA            1539..1612
                     /anticodon=(pos:5490456..5490458,aa:Met,seq:cat)
                     /db_xref="GeneID:76999095"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24360"
                     /product="tRNA-Met"
     gene            1539..1612
                     /db_xref="GeneID:76999095"
                     /locus_tag="FLT43_RS24360"
                     /old_locus_tag="FLT43_24360"
     tRNA            1671..1747
                     /anticodon=(pos:5490588..5490590,aa:Asp,seq:gtc)
                     /db_xref="GeneID:76999096"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24365"
                     /product="tRNA-Asp"
     gene            1671..1747
                     /db_xref="GeneID:76999096"
                     /locus_tag="FLT43_RS24365"
                     /old_locus_tag="FLT43_24365"
     tRNA            1765..1839
                     /anticodon=(pos:5490681..5490683,aa:Glu,seq:ttc)
                     /db_xref="GeneID:76999097"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24370"
                     /product="tRNA-Glu"
     gene            1765..1839
                     /db_xref="GeneID:76999097"
                     /locus_tag="FLT43_RS24370"
                     /old_locus_tag="FLT43_24370"
     tRNA            1843..1918
                     /anticodon=(pos:5490759..5490761,aa:Lys,seq:ttt)
                     /db_xref="GeneID:76999098"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24375"
                     /product="tRNA-Lys"
     gene            1843..1918
                     /db_xref="GeneID:76999098"
                     /locus_tag="FLT43_RS24375"
                     /old_locus_tag="FLT43_24375"
     misc_feature    complement(2246..2260)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.35"
                     /tool="antismash"
     gene            2346..2618
                     /db_xref="GeneID:76999099"
                     /locus_tag="FLT43_RS24380"
                     /old_locus_tag="FLT43_24380"
     CDS             2346..2618
                     /codon_start=1
                     /db_xref="GeneID:76999099"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="FLT43_RS24380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24380"
                     /product="phosphotransferase"
                     /protein_id="WP_087441672.1"
                     /sec_met_domain="APH (E-value: 1.1e-07, bitscore: 30.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVYPEAGHEQVLRDESRFPALIHGDVTFPNVIMHSNGLYLIDWN
                     QVRMESTYYEIAKTLLNTTNFNPLWMGALLQGEWLDEWGRQSGQP"
     gene            complement(2652..3524)
                     /db_xref="GeneID:76999100"
                     /locus_tag="FLT43_RS24385"
                     /old_locus_tag="FLT43_24385"
     CDS             complement(2652..3524)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76999100"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679444.1"
                     /locus_tag="FLT43_RS24385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24385"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_087441671.1"
                     /transl_table=11
                     /translation="MKPLIKVQPHIRAAHMYNYRGAPEEQRRRGYSYAFHLFTEGHGHM
                     IINEQVYPVASGSLIFVRPGEGHYFVPAPGETMDACNIYCDLWCLPQPKQPTFAYQWDD
                     YDPRWLTEQMPCPELDALPTSMSLRPYPHLIELIKQTLVAFNRSGKYTAQAVSACFYSW
                     ILQWHEAGSLTETADYRITRILEQMEACPEQRFSVDYWCSECGLEKSQFYRLFKQETGM
                     SPKAYALQARMKKAAVLLMESRQSITDIALMLGYDSIHYFSNQFSSVYGISPSSFRMGK
                     GYQKVDRWS"
     gene            3641..5623
                     /db_xref="GeneID:76999101"
                     /locus_tag="FLT43_RS24390"
                     /old_locus_tag="FLT43_24390"
     CDS             3641..5623
                     /codon_start=1
                     /db_xref="GeneID:76999101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679445.1"
                     /locus_tag="FLT43_RS24390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24390"
                     /product="alpha-amylase family protein"
                     /protein_id="WP_087441670.1"
                     /transl_table=11
                     /translation="MRYRQVHLDFHTSEHISDIGRNFSKKNFQEMLQLGHVNSITVFAK
                     CHHGWAYFPSATNEIHPRLDFDLLGAQIEAAHEIGVKVPIYISVGFDEKLAWEKPQWLM
                     RDEADRMNWVDSFMKPGYHQFCLNTPYLDLVIEQVQEVVRKYDGDGIFLDIVGERTCYC
                     TTCLKQMQADGLDPHNKEDVIANGRRIYANYTTRIREAIDAIKPGLPVFHNAGHIHQGR
                     RDLMGMNSHLELESLPTGGWGYDHFPLSARYAQPTGFHFLGMTGKFHTFWGEFGGYKHP
                     NALRYETALSLANGARCSIGDQLHPGGQMDRATYELIGKAYAEVEAKEAWCVNAVNLAD
                     VALLTVEAAGVQQESGAMYSGKVDMGAVRMLLEGKILFDIVDLESDWSGYKVLILPDSI
                     VMKDTILPKVEAFLAAGGKVLASGRSGLNVELTRQMLPLGFTDSGLNPFRPDYFRPLCD
                     GMANLGEAAYVMYGDGRRIELTDGTELGRREDPYFNRQAFRFCSHQHAPSSEQEGGPGM
                     VESAQGIYIAWNVFEDYATKGSLILKEMVLFALRRLLGEQITLKTTLPAQGVTTLQHQA
                     AERRYINHLLYASPVKRGERVEIIEDMIPLQQVEVQLQLPVTDVKRVYLAPQMTEIEFK
                     ASGGDVQFTVPQLECHQMVVVEYNE"
     gene            5664..6695
                     /db_xref="GeneID:76999102"
                     /locus_tag="FLT43_RS24395"
                     /old_locus_tag="FLT43_24395"
     CDS             5664..6695
                     /codon_start=1
                     /db_xref="GeneID:76999102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418934.1"
                     /locus_tag="FLT43_RS24395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24395"
                     /product="asparaginase"
                     /protein_id="WP_087441669.1"
                     /transl_table=11
                     /translation="MVDLGKVLVEEYRGNWLECAYTGHMVGVNEQGEPLFSVGDENYVS
                     FMRSSSKPVQALPALMAGVPEHYGLSDEEIVLMTASHRAQQFHVEALESFMRKTGISES
                     QFVCKPTYPLNGAARDELIAHGKPARSIYHNCSGKHLGVLALCKMKGWPTENYAELDHP
                     VQQQVLSLMSALSDVPVEQIRLGTDGCGFPVYALPIRNIATLYLRLACPDLIPDEAIRA
                     AVIRLTTLMNRYPFYVSGTQLICPTLLQDDNIVAKGGAKGIYCFGLRNERMGIAFKVMD
                     GSEDQWPLIAAHILKEIGYPNVETIERLRQLSPPETKNDNGRVVGMREAKFELKWVKNK
                     KKV"
     tRNA            6917..6991
                     /anticodon=(pos:5495832..5495834,aa:Gly,seq:gcc)
                     /db_xref="GeneID:76999103"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24400"
                     /product="tRNA-Gly"
     gene            6917..6991
                     /db_xref="GeneID:76999103"
                     /locus_tag="FLT43_RS24400"
                     /old_locus_tag="FLT43_24400"
     tRNA            6999..7075
                     /anticodon=(pos:5495916..5495918,aa:Arg,seq:acg)
                     /db_xref="GeneID:76999104"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24405"
                     /product="tRNA-Arg"
     gene            6999..7075
                     /db_xref="GeneID:76999104"
                     /locus_tag="FLT43_RS24405"
                     /old_locus_tag="FLT43_24405"
     tRNA            7090..7171
                     /anticodon=(pos:5496006..5496008,aa:Leu,seq:caa)
                     /db_xref="GeneID:76999105"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FLT43_RS24410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FLT43_24410"
                     /product="tRNA-Leu"
     gene            7090..7171
                     /db_xref="GeneID:76999105"
                     /locus_tag="FLT43_RS24410"
                     /old_locus_tag="FLT43_24410"
     gene            complement(7400..8257)
                     /db_xref="GeneID:76999106"
                     /locus_tag="FLT43_RS24415"
                     /old_locus_tag="FLT43_24415"
     CDS             complement(7400..8257)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76999106"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018130257.1"
                     /locus_tag="FLT43_RS24415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24415"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_244194122.1"
                     /transl_table=11
                     /translation="MILRLLLLVLAGLSVLSGCAQNHAQQKPGSTPYSYSAPQPPQILQ
                     NSARSSTPDLADGPEANLREPHALSLADLRAKYPSTFILHGPGTKREIALSFDDAPDDN
                     FTPKVLDVLKSEGVKATFFVVGNRIEKHPDIVKRIVEEGHILGNHSYNHANLPKLSDAE
                     FRDQIIKTDQLIREHTGYTPNIVRPPYGNISEDQIKWLASQKKKIVNWNVDSLDWKGLD
                     AEEVKTNVLAHVSPGAIILQHSAGGTGQDLSGTVLALPDIIRTLQNDGVKLVTIPELLD
                     LNVK"
     gene            complement(8412..8864)
                     /db_xref="GeneID:76999107"
                     /locus_tag="FLT43_RS24420"
                     /old_locus_tag="FLT43_24420"
     CDS             complement(8412..8864)
                     /codon_start=1
                     /db_xref="GeneID:76999107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004434414.1"
                     /locus_tag="FLT43_RS24420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24420"
                     /product="CBO0543 family protein"
                     /protein_id="WP_244194121.1"
                     /transl_table=11
                     /translation="MTTAKHWSGSKLPRSPKKRFTFWNKDSLACAVLGSLLGTYLDLYF
                     VGKGLYHFPYRLLPEIFSIHIVFTLIGLPILTMIFLYCFSQANRWGRVGIIICVSLLMP
                     IFEKIAERLGMFVHSDKWMHLYSFFGYLLFFTIISGVYFGLRKRSG"
     gene            complement(8785..9906)
                     /db_xref="GeneID:76999108"
                     /locus_tag="FLT43_RS24425"
                     /old_locus_tag="FLT43_24425"
     CDS             complement(8785..9906)
                     /codon_start=1
                     /db_xref="GeneID:76999108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007087169.1"
                     /locus_tag="FLT43_RS24425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24425"
                     /product="DUF2515 family protein"
                     /protein_id="WP_087441666.1"
                     /transl_table=11
                     /translation="MRKRHKTPLETIREELKKRKKHSPAILNELTLTEKKLLNKIREIT
                     QDHNLNNVTRTKAYLEFYLRHPEIHWAFLGHMVSRNGGWNMSDLKGEFLATLLAKEERE
                     SFFHFLERGNWLIFQDVYPQFLLYDESLRQKRPMFYLLPQLNVSIFMETVWNYFWRVRD
                     AYILCLALVINEQSYLEQRVIQNPHYQKEVLHKIEFHLQNWLSFNQILFPSEGENVKGQ
                     TLHQFQSLHERILLGKRLYAILFKNKDFHRQALDWATRQPHTGSRKDYWPHLFNDVNEG
                     TPGITYPLRLKSCRLRKGARRIYSPKLEYAWKNVSQPEAEPGDWFQHISVVDYLEVDQE
                     MTDGEIKNDYCKTLERLEIAAFAKKTIHFLEQR"
     gene            10001..11863
                     /db_xref="GeneID:76999109"
                     /gene="shc"
                     /locus_tag="FLT43_RS24430"
                     /old_locus_tag="FLT43_24430"
     CDS             10001..11863
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76999109"
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010281982.1"
                     /locus_tag="FLT43_RS24430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24430"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_087441665.1"
                     /sec_met_domain="T2TS (E-value: 9.9e-106, bitscore: 352.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDTVTGIGWIIETLRKEQSPDGSWAYPFDTGISTDAYMIILLRT
                     LEIDDEELIEGLCRRILSKQQQNGAWKLFYDEGEGNVTSTVEAYYGLLFSGLYRKEDER
                     LRAAKKFILAHGGLSEVSMFTKIMLALTGQYQWPSFTPLPIEMILLPPNFPINFYSFSV
                     FGRANLTPIMILADQKFSMKTVYSPDLSDLKWIRGNEEQWVRSREWRSLLSCIQDGVKR
                     LIGIPGELRRLALERARTYMLDHLEQDGTFYSYYSSTFLMIFALLSLGYKKTDPIITKA
                     VEGIRAMKCEINGLPHLQYTTANVWNTSLIGYTLQAAGVSHEDPMVTKANKYLLSRQHY
                     RFGDWVVHNPNGLPGGWGFSDVNTMNPDVDDTTASLRSISRIASQHPTAWARGISWLLP
                     MQNDNGGWAAFEKNTDSKLLEFLPLEKGRFLLLDPPCADLTGRTLEFLGNYTNRPASHA
                     VIRNAVHWLLKDQRKDGSWYGRWGICYIYGTWGAVTGLKAAGVSKKHPSMQKAAAWLKS
                     IQNADGGWGESCRSDIQMTYVSLTTSTLTDTAWALDALIAIADRPTTAIQKGITFLLDS
                     LEKEDWTTDYPKGQGMGGAFYIHYHSYRYIFPLLALAHYRNKFE"
     gene            12500..12646
                     /db_xref="GeneID:77000239"
                     /locus_tag="FLT43_RS30315"
     CDS             12500..12646
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:77000239"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="FLT43_RS30315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_244194124.1"
                     /transl_table=11
                     /translation="MERASELLKAGIFPIRDIAVSVGYANPLYFSRAFKKKFGMSPSAY
                     ADQ"
     gene            complement(12863..13078)
                     /db_xref="GeneID:76999110"
                     /locus_tag="FLT43_RS24440"
                     /old_locus_tag="FLT43_24440"
     CDS             complement(12863..13078)
                     /codon_start=1
                     /db_xref="GeneID:76999110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679739.1"
                     /locus_tag="FLT43_RS24440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24440"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_087441664.1"
                     /transl_table=11
                     /translation="MAIIINIDVMLAKRKMSVTELSEKVGITMANLSILKNGKAKAVRF
                     STLEKICEVLDCQPGDILEYVQEDPS"
     misc_feature    complement(13055..13069)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 20.1"
                     /tool="antismash"
     gene            complement(13088..13564)
                     /db_xref="GeneID:76999111"
                     /locus_tag="FLT43_RS24445"
                     /old_locus_tag="FLT43_24445"
     CDS             complement(13088..13564)
                     /codon_start=1
                     /db_xref="GeneID:76999111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679740.1"
                     /locus_tag="FLT43_RS24445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24445"
                     /product="DUF2975 domain-containing protein"
                     /protein_id="WP_087441663.1"
                     /transl_table=11
                     /translation="MLRGQTAFLKLAIAMIGITALILSIFWLPGFVTSRAAENPDYISL
                     KYPVLIVVYMTSIPFYIALYQSYKLLQYIERKHAFSDLAVASLKRIKQCAVAIAIIYAI
                     GGAFLGFQSVLLTSIALIGAVIILAAFTVAIFAAVLQELLTHALAIKSENDLTV"
     gene            complement(13655..14461)
                     /db_xref="GeneID:76999112"
                     /locus_tag="FLT43_RS24450"
                     /old_locus_tag="FLT43_24450"
     CDS             complement(13655..14461)
                     /codon_start=1
                     /db_xref="GeneID:76999112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679741.1"
                     /locus_tag="FLT43_RS24450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24450"
                     /product="DUF817 domain-containing protein"
                     /protein_id="WP_087441662.1"
                     /transl_table=11
                     /translation="MAFKLKSFVEFGWQQALSCLFPAIIFAALALARVIDIPYIPAYDF
                     MLLICLAVQIIMIRSRLETMDELKVICVFHLIGLVLEIYKVHMGSWAYPLDGWTKVFGV
                     PLYSGFMYASVASYLCQAWRRLQVKLHRYPKPWCTVPLGAAIYLNFMTHHFIYDLRWVL
                     TILLFAVFFRTYVEYTVLGVTRRMPLVLSFALIGFFIWVAENIGTFLGAWRYPHQANGW
                     NLVQWGKFSSWFLLVIVSFMIVAQLKHVKEGRSHRSHSIEQPLQMP"
     misc_feature    complement(14637..14650)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.94"
                     /tool="antismash"
     gene            14724..15452
                     /db_xref="GeneID:76999113"
                     /locus_tag="FLT43_RS24455"
                     /old_locus_tag="FLT43_24455"
     CDS             14724..15452
                     /codon_start=1
                     /db_xref="GeneID:76999113"
                     /inference="COORDINATES: protein motif:HMM:TIGR01076.1"
                     /locus_tag="FLT43_RS24455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24455"
                     /product="class A sortase"
                     /protein_id="WP_087441661.1"
                     /transl_table=11
                     /translation="MATKKRTAARIIYNAVCAAVLLAGIVMLLHEPIQGWFVSRGTSSL
                     GLDKVAAAGEEKRDNSHVRKQEATFHFEEVAELDFETILMANLHKDEIHVIGGISIPSI
                     DMNLPIGEGVAPYTLALTAGTLKPGQVMGEGNYALAGHHMNRKDLLFSPLLQVKTGAAA
                     YLTDMQYIYEYQIEEQKTIEATAVEVIEDEGTERMLTLITCDDSGKARVLTRGRFVGKT
                     PIQEATKEMKEAFQLEMSNL"
     gene            15597..16340
                     /db_xref="GeneID:76999114"
                     /locus_tag="FLT43_RS24460"
                     /old_locus_tag="FLT43_24460"
     CDS             15597..16340
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76999114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009675145.1"
                     /locus_tag="FLT43_RS24460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24460"
                     /product="YggS family pyridoxal phosphate-dependent enzyme"
                     /protein_id="WP_087441660.1"
                     /transl_table=11
                     /translation="MSDIIEDNLKAVRRRMELACLASGRQKDEVKLLLATKTVPLDKLQ
                     SAIRAGKTLFGENKAQELRGKYADMQQYKQVEWHFIGLLQTNKVKDVVKYVTMIHSVDR
                     IKLGHALHNQLRKENKTMDILVQINTSYEESKFGARPEEALELVEQLSQFDTLNIKGLM
                     TIGKLNATSAETRHCFRLLKRIQTQIIAKNIPGVGMDVLSMGMSGDFEVAIEEGATIVR
                     VGTGIFGERYLPDSYYWNEKAGSHD"
     gene            complement(16391..17821)
                     /db_xref="GeneID:76999115"
                     /locus_tag="FLT43_RS24465"
                     /old_locus_tag="FLT43_24465"
     CDS             complement(16391..17821)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (148-450). E-value: 5e-16.
                     Score: 50.7. Matches aSDomain:
                     nrpspksdomains_FLT43_RS24465_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GeneID:76999115"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010502431.1"
                     /locus_tag="FLT43_RS24465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24465"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_087441659.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.9e-14, bitscore:
                     50.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTINRNDDRPIWQQLLDQAIHNITAGNWPPGQLLLPSRELAHLL
                     GVSRSTIQIVYEELFSRGYTVTSRRGGTRVSEWKQAAGPEADTVTAGPALPELPFLDAA
                     VDHLHHWLGDSGPCQVDINFSPHEPFLDERFHHIWRQSFLQAAAGIDASTWAYGDPCGY
                     LPLREQIQRYLSLERGIHVGVNQILLTSGAQHSLDLIAQSLLREGDTVTVEDPGFPAAW
                     MAMAYRGMNVVPAPVDEYGLQVDRVPPQSKLVFVTPSHQCAVGVIMSEPRRQQLLHLAA
                     SAPCWIVEDDYDSEFRYRGTPLPTLFSQLPRNTLYMMSFSKMIAPGIRLSAIVGSEEAI
                     SRLVRVHRLTYRHLPMMEQLTLAHFIARGHFMRHMRRVRNVYRRRHEAMTKAIMASGLG
                     GRFKLSGVETGSHMLLEAGDTYDEQAATRSALEQGIRVYPLSSYCLASNRKGWVLGFPN
                     VDEAAIQQGISRLAGILL"
     aSDomain        complement(16472..17377)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FLT43_RS24465_Aminotran_1_2.1"
                     /evalue="5.00E-16"
                     /label="FLT43_RS24465_Aminotran_1_2.1"
                     /locus_tag="FLT43_RS24465"
                     /protein_end="450"
                     /protein_start="148"
                     /score="50.7"
                     /tool="antismash"
                     /translation="GIDASTWAYGDPCGYLPLREQIQRYLSLERGIHVGVNQILLTSGA
                     QHSLDLIAQSLLREGDTVTVEDPGFPAAWMAMAYRGMNVVPAPVDEYGLQVDRVPPQSK
                     LVFVTPSHQCAVGVIMSEPRRQQLLHLAASAPCWIVEDDYDSEFRYRGTPLPTLFSQLP
                     RNTLYMMSFSKMIAPGIRLSAIVGSEEAISRLVRVHRLTYRHLPMMEQLTLAHFIARGH
                     FMRHMRRVRNVYRRRHEAMTKAIMASGLGGRFKLSGVETGSHMLLEAGDTYDEQAATRS
                     ALEQGIRVYPLSSYCLASNRK"
     misc_feature    complement(17870..17885)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.85"
                     /tool="antismash"
     gene            complement(18197..18775)
                     /db_xref="GeneID:76999116"
                     /locus_tag="FLT43_RS24470"
                     /old_locus_tag="FLT43_24470"
     CDS             complement(18197..18775)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76999116"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679744.1"
                     /locus_tag="FLT43_RS24470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24470"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_087441658.1"
                     /transl_table=11
                     /translation="MEQWLSFLQRKFQHLDRSSQEMTYQSYRDFIYRDIYFLLQNHELT
                     EDVIQESFLKVIASSPTSKNAANMKAWLKKIARNTAYDYLRKHKKYQYLSNLESIEEKE
                     LFSSEAETAVADQVEEQIRDEMLHEALDQLNARYRNVLFRYYVEDKSHRELARELGISE
                     QASAQLLVRARKKLRYYFCKRWVDREEKR"
     gene            19062..19400
                     /db_xref="GeneID:76999117"
                     /locus_tag="FLT43_RS24475"
                     /old_locus_tag="FLT43_24475"
     CDS             19062..19400
                     /codon_start=1
                     /db_xref="GeneID:76999117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006284172.1"
                     /locus_tag="FLT43_RS24475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24475"
                     /product="hypothetical protein"
                     /protein_id="WP_087441657.1"
                     /transl_table=11
                     /translation="MVMFKNTAAFANTSEVDATGYGKLTGTLSGKSYKTTVSQNRDNAY
                     LTVGGTIQDINGNTLVQQQEIRSSRGSTNLSGSWNALPSKAYAIYGAHGVQGGNTYGAK
                     AVYTYTHV"
     misc_feature    complement(19566..19581)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 21.31"
                     /tool="antismash"
     misc_feature    complement(19599..19614)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.86"
                     /tool="antismash"
     gene            19620..19997
                     /db_xref="GeneID:76999118"
                     /locus_tag="FLT43_RS24480"
                     /old_locus_tag="FLT43_24480"
     CDS             19620..19997
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76999118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679746.1"
                     /locus_tag="FLT43_RS24480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24480"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_087441656.1"
                     /transl_table=11
                     /translation="MRKMKKLPDAEFDIMRVVWANEPPITTAMIMDQLGNERQWKAPTV
                     ISLMMRLVERGFLKTEKEGKERTYYPLIRKEDYLALETQHFMKQYHENSFLSFVNTLYN
                     GKRLTEKELDELLKWAKERRE"
     gene            20001..20927
                     /db_xref="GeneID:76999119"
                     /locus_tag="FLT43_RS24485"
                     /old_locus_tag="FLT43_24485"
     CDS             20001..20927
                     /codon_start=1
                     /db_xref="GeneID:76999119"
                     /inference="COORDINATES: protein motif:HMM:NF017390.4"
                     /locus_tag="FLT43_RS24485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_24485"
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_087441655.1"
                     /transl_table=11
                     /translation="MQGFMIALLECSITMSVIALLYMAITPLLAKTFTAKGRYYGWLVI
                     ILGFIIPFRLHPHVSVIRLDALLPALKMSDGGSARQAVSAAAASSAIPWQAVAGGLWLA
                     GVVVFLAYHAIRHRRFLQMVTRWSTEIRDRQALHMLHDVQAKLGIRQQVALQACPGISS
                     PMLLGFVRPTILLPSDDILSDELPLIFKHELVHLKRRDLWYKALVLVAAALHWFNPVVY
                     VMARDIALQCELSCDEEVVKNTDIAGRQQYVEAIIGMLKKQSVAPTIFSTNFYGSKQGL
                     KNRVLSIWIPEAKNGGCPLLRSLLRRR"
ORIGIN
        1 taaggtagcg aaattccttg tcaggtaaat tctgacccgc acgaatggcg taacgacttg
       61 ggcgctgtct caacgagaga tccggtgaaa ttttaatacc tgtgaagatg caggttaccc
      121 gcgacaagac ggaaagaccc catggagctt tactgcagct tgatattgac tttggtacgg
      181 tctgtacagg ataggtggga gcctgagaag ccggagcgcc agcttcggtg gaggcgccgt
      241 tgggatacca ccctgatcgt atcggagttc taacctggga ccgtggaacc ggttcgggga
      301 cagtgtcagg cgggcagttt gactggggcg gtcgcctcct aaagagtaac ggaggcgccc
      361 caaggttccc tcagaatggt tggaaatcat tcgaagagtg caaaggcaga agggagcttg
      421 actgcgagac ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc ggtggtaccg
      481 catggaaggg ccatcgctca acggataaaa gctaccctgg ggataacagg cttatctccc
      541 ccaagagtcc acatcgacgg ggaggtttgg cacctcgatg tcggctcatc gcatcctggg
      601 gctgaagtag gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc gagctgggtt
      661 cagaacgtcg tgagacagtt cggtccctat ctgtcgcggg cgtaggaaat ttgagaggag
      721 ctgtccttag tacgagagga ccgggatgga cgtaccgctg gtgtaccagt tgtctcgcca
      781 gaggcatagc tgggtagcca agtacggaag ggataagcgc tgaaagcatc taagcgtgaa
      841 gcccccctca agatgagatt tcccacattg gtaagacccc ttgaagacga cgaggtagat
      901 aggttggagg tggaagtgca gcaatgcatg gagctgacca atactaatcg gtcgagggct
      961 tatcctaact aagatgattc gcaagacaaa ctttcgcatt cagtttttaa ggtacaatac
     1021 cttatctgtt tggtggcgat agcggagggg ttccacgcgt acccatcccg aacacgaccg
     1081 ttaagccctc cagcgccgat ggtacttgga ccgcagggtc ctgggagagt aggacgttgc
     1141 caagcagagg ctttacatat cggtctccgg cgaagtccga gagatacgtt acattccctg
     1201 atagctcagt cggtagagca ctcggctgtt aaccgagttg tcacaggttc gagtcctgtt
     1261 cggggagcca cacggagaga tgtccgagct ggccgaagga gcacgattgg aaatcgtgta
     1321 ggcgtcacaa gcgtctcgag ggttcaaatc cctctctctc cgccagcgtg gcccgttggt
     1381 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc
     1441 accattacat tcatatggac acttagctca gttgggagag caccatcttg acagggtggg
     1501 ggtcagcggt tcgaacccgt tagtgtccac catattatcg cggggtggag cagttcggta
     1561 gctcgtcggg ctcataaccc gaaggtcgca ggttcaaatc ctgtccccgc aatattattt
     1621 ccatcgagag cggttattac gcatcgatgc ggaaaatgaa taacaactat ggagctgtgg
     1681 tgtagaggcc taacatgcct gcctgtcacg caggagaacg cgggttcgaa tcccgtcagc
     1741 tccgccatta ttatgaaatg ctggggcccg ttggtcaagc ggttaagaca ccgccctttc
     1801 acggcggtaa cacgggttcg aatcccgtac gggtcaccat gcgagccatt agctcagttg
     1861 gtagagcacc tgacttttaa tcagggtgtc gaaggttcga gtccttcatg gctcaccagt
     1921 atgcattcaa caagcttgcg cagatgcgca ggcttttttc tttttttgcc tgctaagaag
     1981 ggaccgtgaa ccattctacg aatacattgt aaccatgtgc agggaaaaga atggaggatg
     2041 gcagcttggc aaggcgaatc agtacagcac agcttagacc gtttgtccgg cgatacgggc
     2101 tgcatttgcg tcacattcag ccctgccatt cgctgtatcg acgccatgcg gcatttcggg
     2161 cgctggccac gcttcatacg atatgtcagg ccgctcttcc ccatgtctcc atacacttcc
     2221 cgtcagattt cacttttcca agatcaggac cgaatgttcc gccgccgatt gacgatgatg
     2281 cgtaagcgga agggcggcct ggttcagggt acatagcatc agtgcattcg cttggctgag
     2341 gaggcgtgga ggtctatcca gaggccggcc acgagcaggt gctccgggat gaaagccggt
     2401 tcccggcatt aatccacggg gatgtaacct tcccgaatgt cattatgcac tcgaatggct
     2461 tgtatttaat tgattggaat caggtcagaa tggagtcaac ctattacgaa atcgcaaaga
     2521 cgcttttgaa taccacgaat ttcaatccgc tgtggatggg agcgctgtta cagggggaat
     2581 ggctggatga atggggccgc caatcaggcc agccgtagct tgctcgcaag cacaagctgg
     2641 cccgagcatc gttatgacca gcgatcaacc ttctggtacc ctttgcccat ccggaaggat
     2701 gaggggctga ttccgtatac ggaggagaat tgattagaga aataatgaat ggaatcgtat
     2761 ccgagcataa gcgcgatgtc cgtaattgat tggcggcttt ccatcaacag gacggccgct
     2821 tttttcatgc gggcctgcag cgcgtacgct ttgggcgaca ttccggtctc ctgcttgaac
     2881 agccgataga attgcgactt ctccaatccg cactcgctgc accagtaatc tacggagaac
     2941 cgctgctccg gacaggcctc catctgctcc aatatgcggg taatccggta atcagccgtc
     3001 tcggtcagac tgccagcttc atgccattgc aatatccagg aataaaagca ggcggagacc
     3061 gcttgcgccg tatatttgcc ggaacggttg aacgcaacca gcgtctgctt gatcagctcg
     3121 atcagatgcg ggtaaggccg cagcgacatg ctcgtcggca gcgcatccaa ttcggggcag
     3181 ggcatctgtt ccgtaagcca ccggggatca tagtcgtccc attgataagc gaaggttggc
     3241 tgcttaggct ggggcaggca ccataagtcg cagtaaatat tgcaggcatc catcgtttcc
     3301 cccggggccg gaacgaaata gtgcccctct cccggacgga cgaagatcag gctgccgctg
     3361 gcaacggggt agacctgttc attgataatc atatgtccat ggccttccgt gaaaagatgg
     3421 aaggcatagc tgtagcctct gcgccgctgc tcctcgggag ccccgcgata gttgtacata
     3481 tgggccgcac ggatatgggg ctgtacctta atgagcggtt tcatcgtttt tcctccacat
     3541 gatcggaatt ttgtataaat gaaaggaagc tgtcttaaat acgtccgcct atgtaaatga
     3601 tacaatgatc tcaagaaaat gtcatgtata ggaggatatt atgcgctaca gacaggttca
     3661 cctcgatttc catacgtcgg agcatatttc tgatatcggg agaaattttt ctaaaaagaa
     3721 ttttcaagag atgctgcagc tgggacatgt gaactcgata accgtgttcg ccaagtgcca
     3781 tcacggctgg gcgtacttcc cttcggcaac gaatgaaatc catccgaggc ttgattttga
     3841 cctgcttggc gcccagatcg aagcggcgca cgagatcggc gtcaaggtgc caatttatat
     3901 atccgtcggc ttcgatgaga agctggcttg ggagaagccg caatggttga tgcgggatga
     3961 agcggaccgg atgaactggg tcgactcctt catgaagccg ggctatcatc aattttgctt
     4021 gaatacgccc tatcttgatc tagtcattga gcaggtgcag gaagttgtgc ggaagtatga
     4081 cggcgacggc atattcctcg atattgtagg cgagcggacg tgctattgta cgacctgtct
     4141 gaagcaaatg caggcggatg gcctcgatcc ccataacaag gaagatgtga ttgcgaacgg
     4201 ccgccgcatt tacgcgaatt acacgacacg catccgggaa gcgatcgacg cgatcaagcc
     4261 gggattgccg gtcttccata acgcgggaca tattcatcag gggcgccgcg atcttatggg
     4321 tatgaactcc catcttgaac tggagtcgtt gccgacaggc ggctgggggt atgatcattt
     4381 tccgctgtct gcccgctacg cccagcccac cgggttccat ttcctcggca tgaccgggaa
     4441 attccatacc ttctggggcg aattcggcgg ttacaagcat ccgaacgcct tgcgctatga
     4501 gactgcgctg agcttggcga acggtgcccg ctgctcgatc ggagaccagc tccaccctgg
     4561 cggacagatg gaccgggcca cgtatgagct gatcgggaag gcgtacgcgg aagtggaggc
     4621 caaggaagca tggtgcgtca acgcagtcaa ccttgcggat gtcgcgctgc ttacggtaga
     4681 ggccgccggc gtgcagcagg aaagcggagc catgtattcc ggcaaagtcg atatgggtgc
     4741 ggtccgcatg ctgctggaag gcaaaatctt gttcgatatc gtagacctgg aaagcgactg
     4801 gagcggctat aaggtgctca ttctcccgga ctcgatcgtg atgaaggata ccattttgcc
     4861 gaaggtggag gctttcttgg ctgcaggggg caaagtgttg gcgtccgggc gttccggcct
     4921 gaatgtcgaa ctgacgcggc agatgctgcc ccttggcttc accgatagcg gactgaatcc
     4981 gttccgtccg gattatttcc gtccgctctg cgatggaatg gcgaatctcg gagaagcggc
     5041 ttatgtcatg tacggagacg ggcgccgcat cgagctgaca gacgggacag agcttggaag
     5101 aagggaggat ccgtacttca accgccaggc cttccgtttc tgttcccatc agcatgcgcc
     5161 gagttctgaa caggagggcg gtccaggcat ggtcgaatcc gcccaaggca tttatatcgc
     5221 ttggaacgta tttgaagatt atgcgacgaa gggcagtctc attttgaagg aaatggttct
     5281 gttcgcgctt cgccggctgc tcggggagca gatcacgttg aagacgacac tgcctgccca
     5341 gggcgtgacg acgctccagc atcaggcagc agagcgccgc tatatcaatc atttgctgta
     5401 tgcttccccg gtgaagcgcg gggaacgggt cgaaatcatt gaagatatga ttcctctaca
     5461 acaggtcgag gttcagctcc agctgccggt gaccgacgtg aagcgggtct atctggctcc
     5521 gcaaatgacc gaaatcgagt tcaaggcgtc cgggggagat gtgcaattta cggtgcctca
     5581 attggaatgc caccaaatgg tcgtcgtaga gtataatgag tagcagcagg acagtcatcc
     5641 cggagttgcg aggaggaacc aacatggtag acttgggtaa agtgttagta gaagagtatc
     5701 gtggcaattg gttggaatgc gcgtataccg gccatatggt cggtgtgaat gagcagggag
     5761 agccgctatt ctcggtaggg gatgagaact atgtcagctt catgcgttca tcatcgaagc
     5821 cggttcaggc gctgcccgcg cttatggccg gagtgccgga gcattatgga ttgagcgacg
     5881 aggagatcgt gctcatgacg gcatcgcacc gggcgcagca attccatgta gaagcgctgg
     5941 aatcgttcat gcgcaagacc ggaatctcgg agtcgcagtt cgtatgcaag ccgacgtatc
     6001 cgctgaacgg agcggcccgt gacgagctga tcgcccatgg caagcctgcg cgctccatct
     6061 accataattg ctcgggcaag catctcgggg tgctggccct ctgcaaaatg aaaggctggc
     6121 cgactgagaa ctatgccgag ttggaccatc cggtgcagca gcaggtgctg tctctgatgt
     6181 ccgcgctttc ggatgtgccg gtcgagcaga tccggttagg gacggacgga tgcggcttcc
     6241 cggtctatgc gctgccgatc cgcaatatcg ctacgctgta cttgcggctt gcttgtccgg
     6301 atctgattcc ggatgaggcg atccgagcgg ctgtcatccg cttgacgacg ctaatgaacc
     6361 ggtacccgtt ctacgtatcc ggcacgcagt tgatctgtcc gacgcttctg caggacgaca
     6421 acatcgtcgc caaaggcgga gccaaaggaa tctactgctt cggcttgcgg aatgagcgta
     6481 tggggatcgc cttcaaagtg atggacggct ccgaggatca atggccgctc atcgcagccc
     6541 atattttgaa ggagattgga tatccgaacg tggagacgat cgagcgtctg cggcagctca
     6601 gtccgccaga gacgaagaat gacaatggcc gggtcgtcgg catgcgggaa gcgaaattcg
     6661 aattgaagtg ggttaagaat aagaagaaag tataagtata taccgtcttg tccgaagggt
     6721 taaccctgaa gacaaggcgg ttttttccat tcttgccctc atattaaaga agagaaagct
     6781 aaggaaaaaa catcactttt catcaaaaaa gaattgattt tcgaaaggtg gtctgttata
     6841 ttaataaatg tccttcttga agcatgctct cgcggcaagc gagggaatga cgatggacag
     6901 gctggacagc cgatgcgcgg acatagctca gtggtagagt atcgccttgc caaggcgagg
     6961 gtcgcgggtt cgaatcccgt tgtccgctcc agaagaatgc gcccttagct cagccggata
     7021 gagcgtttga ctacgaatca aaaggtcggg agttcgaatc tctcagggcg cgccagatta
     7081 actttatagg ccggtgtggc ggaatggcag acgcgcgcga ctcaaaatcg tgagggaaac
     7141 cgtggaggtt cgagtcctct caccggcacc agcataagcg atgaagttct ttggggttaa
     7201 aaaatcctaa aggacttttt attttttaag ctgtaaacat tgcttattgc atgagcggaa
     7261 ctaatttact gctggatggt aatagttatg gtatcgttat tctccgtaag gcttaacaca
     7321 tcgcgggtgt tgtcgcaaag gatgaaacga ttacgaaggc aatgttgatc gttcctgacg
     7381 tatcctttcc ggtaagcctt tatttcacgt tcagatccag caattcgggg atggtcacca
     7441 acttcacccc atcgttttgc agtgtacgaa tgatgtccgg caaagccaaa accgttccgg
     7501 ataaatcttg gcctgttcct ccggcagaat gttgcaaaat aattgcccct ggggatacat
     7561 gagcaaggac atttgtcttc acttcttctg catccaaacc tttccaatcg agggaatcga
     7621 cattccagtt gacgatcttt ttcttctggc ttgccaacca cttgatttga tcctcgctga
     7681 tattaccata aggcggccgg acgatattgg gggtatatcc ggtatgctcg cgaatcaatt
     7741 gatccgtttt aataatttga tcgcgaaatt ctgcatcgct taatttaggc aaatttgcat
     7801 ggttgtaaga atgattgcca aggatatggc cttcctcgac aatccgtttc acgatgtcgg
     7861 gatgcttctc gattctgttt ccaactacga aaaaagttgc tttcacgcct tcgcttttga
     7921 gtacatccaa caccttcggg gtaaagttgt catctggcgc atcatcaaat gaaagggcaa
     7981 tttcccgttt cgtaccggga ccgtgcagta taaacgttga tgggtacttc gcccgcaaat
     8041 ccgccaagga aagggcatgc ggctcacgca aatttgcctc aggtccatct gcaagatctg
     8101 gtgttgaaga tctagcggaa ttttgcaaaa tttgcggtgg ttggggagcg ctgtagctgt
     8161 aaggagtgct gccgggcttt tgttgcgcgt gattctgagc acatcccgac agcacactaa
     8221 gccctgctag aactaataac aataaacgca agatcatctt tcctccattt ctttggaaat
     8281 cacgtgctta tagaattaca caatgtgaat aaattattcg tggcttctct tctccagtct
     8341 gcggagaagg gcgagaatga gtcttgcggc tcaaaatcgt gagggaaact atggagattc
     8401 aagttttgtt tttacccact tctttttctc agcccaaaat aaacccctga aattatcgta
     8461 aaaaacagta aataaccgaa gaagctgtat aaatgcatcc atttatcgga atggacaaac
     8521 atccctaatc gctccgctat tttttcaaaa atcggcatca gcaggctgac acagataata
     8581 atccctaccc ttccccaacg atttgcttgg gagaagcagt acagaaaaat catcgtcaat
     8641 ataggcaacc cgattaaagt gaagacgata tgaatcgaaa agatctccgg tagcagccgg
     8701 taaggaaaat gatacagccc tttaccgaca aaatagagat ctaaatacgt accaagcaac
     8761 gatcccagta ctgcacatgc taaactatct ttgttccaaa aagtgaatcg tttttttggc
     8821 gaacgcggca atttcgagcc gctccaatgt tttgcagtag tcattcttaa tctctccgtc
     8881 cgtcatttct tggtcaacct ccaaataatc caccacgctt atatgttgaa accaatcccc
     8941 cggttctgct tccggctggc tgacattttt ccaggcatat tccagcttgg ggctgtaaat
     9001 tctccttgct cccttgcgaa gccggcacga ttttaaccgt aatggatagg taattcccgg
     9061 tgtgccttca tttacatcat taaataaatg cggccagtag tctttcctcg atccggtatg
     9121 cggctgacgt gtcgcccaat ccagagcctg cctatgaaaa tccttatttt taaacaaaat
     9181 cgcatacagc ctttttccaa gtaaaattcg ctcatggaga gactggaatt ggtgaagggt
     9241 ctgccccttt acgttctcgc cttccgaagg aaacagaatt tgattaaacg atagccagtt
     9301 ctgaaggtga aattcgatct tgtgtaatac ttctttttga taatggggat tttggatgac
     9361 cctttgttcc aaatagctct gttcattgat gactaacgct agacaaagaa tatacgcatc
     9421 tcggactctc caaaaataat tccaaaccgt ttccataaaa atagaaacat tcaattgagg
     9481 cagcagataa aacataggtc tcttttgccg taaactctca tcgtaaagca gaaattgcgg
     9541 gtatacatcc tggaaaatca gccagttgcc gcgttctaaa aaatgaaaaa aggattcccg
     9601 ctcctctttt gcaaggagtg tggctaaaaa ttctcccttg agatcgctca tattccagcc
     9661 gccattccgc gataccatat ggcctaaaaa tgcccagtgg atctcaggat gccggagata
     9721 aaactcgaga taggcttttg ttctcgtcac attatttagg ttgtggtcct gtgtaatctc
     9781 tctgattttg tttaaaagct ttttctcggt aagagttagc tcattcaaga tggcagggga
     9841 gtgtttcttt cttttcttta attcctcgcg aatcgtttca agcggcgttt tgtggcgttt
     9901 tcttattaaa aagatggcag cttccctccc tcatgaattc tcgataacag agccgaatat
     9961 gtatagctta aaggcttttg cgggaggaag gagtatgggg atgattgata ccgtcacagg
    10021 gatagggtgg attattgaga cacttcgcaa agagcaatct cccgatgggt catgggctta
    10081 tccgtttgat acgggtattt ctaccgatgc ctatatgatt attttattac ggactttaga
    10141 gattgatgat gaggaattaa tcgaggggct ttgccgcaga attttaagta aacagcagca
    10201 aaatggagca tggaagcttt tttatgatga aggagaagga aatgtaacct ccactgtaga
    10261 agcctattac ggactgcttt tttccggatt gtaccgtaaa gaagacgagc gtcttcgcgc
    10321 tgccaaaaag tttattctcg ctcacggcgg tttatcggaa gtaagcatgt ttacgaaaat
    10381 catgctggca ctgaccgggc aatatcaatg gccgtccttt acccctctgc ctattgagat
    10441 gattctgctc ccgcccaact tccctatcaa tttctattct ttttctgttt tcgggagagc
    10501 caacctgact ccgattatga tactggctga tcaaaagttt tcgatgaaaa cagtatattc
    10561 ccccgacctg tctgatttga aatggataag ggggaatgag gaacaatggg ttcgctcaag
    10621 ggaatggcgc tcgctgctct cctgtattca ggacggagtc aaaagattga tcggcatccc
    10681 gggggaactg cgccgcttag cgcttgagcg tgcccgaacc tatatgctgg accatttgga
    10741 gcaggatgga actttttata gttattacag cagtaccttt ttgatgattt ttgccctgct
    10801 gtccttaggc tataaaaaaa ccgatccgat cattacaaag gccgtcgagg ggattcgggc
    10861 aatgaaatgc gaaattaatg gcctccctca tttgcaatac accacggcca atgtgtggaa
    10921 tacctcgtta ataggttata cccttcaggc agcgggagta tcgcatgaag acccaatggt
    10981 gacgaaggct aacaagtatt tgctgagccg ccagcattac cgcttcggcg actgggtcgt
    11041 gcacaatccc aacggcttgc cgggcggctg gggtttttct gatgtgaata cgatgaatcc
    11101 ggatgtggat gacacgacgg cctcgttaag gtccatatcc agaattgcgt cgcagcatcc
    11161 aacggcctgg gcaaggggca tcagctggct tttgccgatg cagaacgata atggcgggtg
    11221 ggctgctttt gaaaaaaata cggattccaa gctattagaa tttcttccgc ttgaaaaggg
    11281 ccggtttttg ctgctggatc ccccttgtgc ggatttgacc gggagaacgc ttgaattttt
    11341 ggggaactat actaaccgtc ccgccagcca tgcggttatc cggaatgctg tgcattggct
    11401 gttaaaagat cagcggaagg acggttcgtg gtacgggcgc tgggggatct gctatattta
    11461 tgggacatgg ggcgctgtta ccggtttgaa agcggcgggc gtatcgaaaa agcatccaag
    11521 catgcaaaag gcggccgcat ggctgaagag tattcagaat gcggacggcg gatggggcga
    11581 atcgtgccgc agtgacattc aaatgaccta cgtttcgttg acgacgagca cgctgacgga
    11641 tacggcttgg gcgttagatg ccttgatagc cattgcagac cggccgacga cggctatcca
    11701 aaaaggtatc acctttttgc tggattctct tgaaaaagag gattggacca cggactatcc
    11761 caaaggccaa gggatgggag gagcgtttta tatccattat catagttacc ggtatatctt
    11821 tcctctactt gcattagcgc attaccgaaa caagtttgaa taacgaacta ttccgtcccg
    11881 ccctgaggag gatgctcttc gcgggaacct gtagaccgtc aaagaacagc tacaccactg
    11941 gtaggggcta gctccaaaaa ggtgatacaa taatccgtga aattgccgat tcaacaatga
    12001 ctgagcaggc ccaagtgctc catattggga tagagagcag gtgcgatatc atggtagatg
    12061 tggagaagtt agccggggta tttggcaatg atcccaatga tatagaagat gtctatcgtt
    12121 tagtgatcca gccgaaaagt gttttgcgtg aatttcgaac cgttaggcat ggatttcttt
    12181 ttacagttcg cggacaagct agaatctgtg tgaatggaac gatctacgat ttacatccag
    12241 gattcgtatt tcatgcggct ccagacatgc agttggaatc gagagtgata ggtcaatccg
    12301 agttggaata ttattctgtt ttttatcgcc tggacaagag gcgggaagac aacagcgatc
    12361 atgaatgtaa tgctcatttc aagctggagc ctggagccaa cccgagattg atcgaattac
    12421 tgactatgcc tcatcagaat gctcaaacac ttggagggct tgggaaactt cgcgtgaagg
    12481 aattattttt atgtatcgta tggaaagagc gagtgaattg cttaaagcgg gcatttttcc
    12541 tatccgtgat attgctgtca gtgtcggcta cgccaacccg ttatatttca gccgagcgtt
    12601 taaaaaaaaa ttcggcatgt ctccctctgc atacgcagat caataaaata ttcttatcta
    12661 tgagtgaaga tggatgtgtt tcagctccgg attagataat atttgttcag aagagaatat
    12721 acaggctcga ctctaaagga ccatttaggc aggcaagatc tgtcattggt atgacccgaa
    12781 gccgattgcc aagcaggtgc gggtcaatag ggaagaatga aaaatgcccc ggcttggatg
    12841 aaagcgcggg gctggttttc gttcaggacg gatcctcttg tacatattcc aatatatcac
    12901 ctggctgaca gtccagcact tcgcatattt tctccaaggt ggaaaagcgg accgccttcg
    12961 ctttgccatt tttcaggatg gacaggttcg ccatcgtaat gccgaccttc tccgacagct
    13021 cggtgacgct catttttcgt tttgccagca taacatcgat attgatgata atcgccatat
    13081 gaacacctca gaccgtcaaa tcattttctg atttgattgc aagtgcgtgg gttagcagtt
    13141 cttgaagcac tgccgcaaaa atcgctaccg tgaatgcggc caaaatgatg actgctccta
    13201 tgagtgcgat ggaagtgagc aggacgctct ggaagccaag gaatgcgccg cctattgcat
    13261 agatgatcgc gattgcaacg gcgcactgtt tgatgcgctt caacgatgct acagcgagat
    13321 cggaaaaagc atgttttcgt tcgatatatt ggagcagctt gtaagattga taaagagcaa
    13381 tataaaaagg tatcgatgtc atatatacaa cgatgagcac cggatatttc aaagagatgt
    13441 aatccggatt ctccgctgca cggcttgtca cgaatccggg cagccagaat attgacagaa
    13501 tcaaagccgt aatcccgatc atggcgatag ccagtttaag aaaggcggtt tgtcctcgca
    13561 gcatacagca cctcgcataa aatgaatggc aatagcatat cactgcattt atcgtctttc
    13621 aatatgtttt tcatgtttct tagtaaacat ctctttatgg catctgaagc ggctgttcta
    13681 tgctatggga tcggtgggag cggccctcct tcacatgctt caactgggcg acgatcatga
    13741 acgacacgat gaccagcaag aaccatgagc tgaatttccc ccactgaaca agattccaac
    13801 cgttggcctg atggggatag cgccaagcgc ccaggaacgt cccgatattt tccgctaccc
    13861 aaataaagaa accgatcaac gcaaacgaca gtacgagcgg catccgccgc gtcacgccca
    13921 gcaccgtata ttcgacatat gtgcgaaaga agacggcgaa cagcagaatg gtcaacaccc
    13981 agcgcaaatc gtagatgaaa tgatgggtca tgaaattgag gtaaatcgcc gccccgagcg
    14041 ggacggtaca ccacggcttc ggataccggt gaagcttcac ttgcagccgg cgccacgcct
    14101 ggcataagta actggcgacg ctggcataca taaatccgct atagagcggc acgccgaaca
    14161 ctttagtcca gccgtcgagc ggataagccc atgatcccat atgaactttg taaatttcaa
    14221 gcacgagccc gatcagatgg aatacgcaaa tgacctttaa ctcgtccatc gtttccagcc
    14281 tggagcggat catgatgatt tgaaccgcga gacagataag gagcatgaag tcgtaagcgg
    14341 gaatgtacgg gatgtctatc acccgcgcga gtgcaagcgc cgcaaaaata atggccggga
    14401 acaggcagga cagcgcctgc tgccagccga actcgacaaa tgatttaagc ttgaaagcca
    14461 tgatacgttc ctcctgcatt ggaatccgtc tgacggaagg acagtgcttc tccgcaacgg
    14521 cacttgaatg agccgccaat gcggctcgac aggtattatc ataatcgtgc gcatcctctt
    14581 ggtcaataaa aatttattgt ttatcgataa atatttattg tttaagttgt ccttgtttag
    14641 attttgtcta gttttcaggt gtcgctgctt gaagaagtcc tctataatta aagcggaaag
    14701 aaatacgctc gggaggatcg tgaatggcca caaagaagag aaccgccgca aggataatct
    14761 ataatgccgt ctgtgccgcc gttctcttgg ccggtattgt catgctgctt cacgagccta
    14821 tccagggctg gttcgtctcc agagggacga gctcattagg gcttgacaag gtggctgcgg
    14881 caggcgagga gaagcgggac aacagccacg tccgcaagca agaagccacc tttcattttg
    14941 aagaggtggc ggaactggat ttcgagacca tcttaatggc gaatttgcac aaagatgaga
    15001 ttcacgtgat cggcgggatc agcatcccga gcattgatat gaatttgccg ataggagaag
    15061 gcgtggcccc gtatacgtta gcgctcacgg cgggaacgct gaagcccggc caggttatgg
    15121 gagaaggcaa ttatgcgttg gccggtcatc atatgaaccg caaagatctg ctgttcagcc
    15181 cgctgctgca agtcaaaacg ggcgcggcag cttatttaac cgatatgcag tatatctatg
    15241 aatatcagat tgaggagcaa aaaacgatcg aagcaaccgc ggtcgaagtc attgaggatg
    15301 agggcacgga acgaatgttg accttgatca cctgtgatga cagcggcaag gcgcgggtgt
    15361 tgacgagagg ccgatttgtc ggcaagacgc cgattcaaga ggcgacgaag gaaatgaagg
    15421 aagcctttca gctggaaatg agtaacttat agccattgag ggtgcgagtg aatcggcggc
    15481 taacgattat ggacctcgaa gaataccaac tttggacgtg ttcaacccat ccaaatttca
    15541 ttaagctgaa aatatggaat ttttgcctgt taggcaagca agcaggaggg gagaacgtga
    15601 gcgatataat cgaagacaac ctgaaggcag tgcgccgtcg aatggaattg gcttgtctgg
    15661 cctccgggcg gcagaaggat gaggtcaagc tgctgctggc taccaagacc gtgccgcttg
    15721 acaaattgca gagcgcgatc cgggcgggaa agacgttatt cggggagaac aaagcccagg
    15781 aacttcgcgg caaatatgcg gatatgcagc agtacaagca ggtggaatgg cattttatcg
    15841 gacttctcca gacgaataaa gtgaaggacg tcgtcaaata tgtcacgatg atccactccg
    15901 tcgatcggat caaattgggt catgctctac ataatcaatt gcggaaagag aataaaacca
    15961 tggatattct cgttcaaatt aatacctcct acgaggaaag caaatttggc gcgcggccgg
    16021 aagaggcgct ggaactggtg gaacagcttt cccaattcga cacgctgaat ataaaggggc
    16081 ttatgaccat cggcaagctg aatgccacga gcgccgagac ccggcattgc tttcggctat
    16141 tgaagcggat ccagacccag attatcgcca agaatatccc gggtgtgggg atggacgtgc
    16201 tctctatggg aatgtccggt gatttcgagg tcgccattga agaaggagcc acgatcgttc
    16261 gggtagggac gggaatattc ggtgagcgct atttgccgga tagttattat tggaacgaaa
    16321 aagcaggctc gcatgattaa gcgatgcttc ctatagttgc cgccacagcc ggaggacttg
    16381 cgggacgata ctagagcagt atgcccgcaa gccggctaat accctgctga atggccgctt
    16441 cgtctacgtt cgggaagccg agcacccatc ctttgcggtt gcttgccaag caatatgagc
    16501 taaggggata gacgcgtatg ccttgttcca gtgcacttct ggtcgcggct tgctcatcat
    16561 atgtgtcccc ggcttccagc agcatatgcg agccggtctc gacaccggag agcttgaatc
    16621 ggccgcccag gccgcttgcc attatcgctt tggtcatcgc ttcgtgtctg cgccggtata
    16681 cattgcggac tcttctcata tggcgcataa aatggccgcg ggcgatgaaa tgagcaagcg
    16741 tcagttgctc catcatcggc agatgccggt aagtcaatcg atgaacccgg accagacggc
    16801 tgatcgcttc ttccgatccg acaatggcgg agagccgaat gccaggggca atcattttgg
    16861 aaaagctcat catatacaag gtgttgcggg gcagctggct gaacagcgtc ggcagcggag
    16921 ttccgcgata acggaattcg ctgtcgtaat catcctccac aatccagcat ggagccgaag
    16981 cggccaggtg cagcagctgc tgcctgcgcg gctccgacat aatgacgcca accgcgcact
    17041 ggtgcgaagg cgtcacgaag acgagcttgg attgcggcgg gacgcggtcc acctgcaagc
    17101 cgtattcgtc aacgggagcg ggaacgacat tcattccccg gtatgccatc gccatccagg
    17161 cggcggggaa gccaggatcc tcgaccgtga ccgtgtctcc ttcacgcaag agcgattgcg
    17221 ctataaggtc aaggctgtgc tgggcgcccg aggtcagcag aatctgattc acccccacgt
    17281 gaatcccccg ttccagcgac aagtagcgct gtatctgttc ccgcaagggg aggtagccgc
    17341 acggatcgcc gtatgcccaa gtgcttgcat cgatgccggc agccgcctgt aagaacgact
    17401 ggcgccatat gtgatgaaag cgctcgtcca aaaaaggctc gtgggggcta aaattgatat
    17461 ccacctggca cggaccgctg tctcccagcc agtggtgcag atgatcaacc gccgcatcca
    17521 gaaaaggaag ctcaggcagc gctggccctg ccgttaccgt atcagcttcc gggccggcag
    17581 cttgcttcca ctcgcttacg cgggttcctc ctcgccggga ggtgacggtg taaccccggc
    17641 tgaacagctc ctcgtacacg atctggatgg tggaacgcga gacgccaagc aaatgtgcga
    17701 gttcccgcga cggaagcagc aattgtcccg gcggccaatt gccggccgtt atattgtgga
    17761 tcgcctgatc aagcagttgc tgccatatgg gccgatcatc attacgatta atcgtcaaca
    17821 ttccgttcac ctccggttca gacacgggtt gcgaagctag tatggattgg tcaaaaatat
    17881 gtgtattgga catgttcgtc cattccaatg gttgatatac tagcataacg aatggcgttg
    17941 aacaagatat tagcgtgaaa gaatgggagt atccgcatac agaggaggtt gggttgcggt
    18001 atgaccgatt ggagtgggag tggacatgaa cattcattat aacgaaaaag agattggctg
    18061 gtttcctgtc actttgacgg aggagagcag ggaatccgtg ttttttagga gctgcggccg
    18121 cttctcggga tgcaaccggg gagcggctgt gtgcttactt gcgccgggag gctgccgctg
    18181 tctcccgcat aagacattat cttttttctt cgcgatcaac ccatcttttg caaaagtagt
    18241 aacgcaattt tttgcgcgcc ctaaccaata attgcgcaga agcttgctcg ctgatcccta
    18301 attcccgggc cagctctcga tgtgacttat cttccacata gtagcgaaac agcacattgc
    18361 gatatctcgc attaagctgg tcaagagctt catgaagcat ttcatcgcga atttgttcct
    18421 ccacttgatc ggctacggcc gtctcggctt cggaagagaa cagttccttt tcctctatgc
    18481 tctccaggtt ggataaatat tgatattttt tgtgtttcct caaataatca taggcggtat
    18541 tccgcgcgat ttttttgagc cacgccttca tattggccgc atttttcgat gtaggcgatg
    18601 aggcaatcac tttcaagaag gattcttgga taacatcttc cgtcagttca tgattttgga
    18661 gtaagaagta aatgtcacgg tagatgaaat cccggtagga ttggtaagtc atttcttgag
    18721 atgagcggtc caggtgttgg aacttacgct gtaaaaaaga caaccactgt tccataatgc
    18781 cccctccacg aactggcaag catatgtttc tggctcgccc tttttttcta tatatactaa
    18841 tatatactaa aagggtggat tgatctatga aatatctcat aattcttact agtttataca
    18901 ttaaaaaata atttcgtcat attttggtag attaatccgt ctactatata gagaaacctt
    18961 catcatgact ttacatctat catctaacgg gcaggaggtg tgtgtccccc gcaacgtctg
    19021 atgcaatgta aagttctgca ggaagttttg aagtcaaggt catggtaatg ttcaaaaaca
    19081 cggcggcgtt tgcaaacact tcagaagtgg atgcaacagg ttatgggaaa ctgaccggca
    19141 cgttatcggg taaatcctat aagacaacgg tctctcaaaa tcgtgacaat gcgtacctga
    19201 cagtcggagg gacgattcaa gacattaacg gcaatacact tgtccagcag caggaaattc
    19261 gcagttctag aggatcgact aacttatcgg gctcctggaa cgcgttgcct tccaaagctt
    19321 atgctattta tggggcgcat ggcgtgcagg gtggaaacac ctatggcgct aaggctgtat
    19381 acacttacac acacgtgtaa tctggagtaa gagcagggta atggctgcgt agaagaatgt
    19441 ttataccaat gcggatgaag tctgcctaga ctttgtttgc ttggtataaa catcttcttt
    19501 tttataacgg gaaatacata ttaggcaatt gtaaaaaata ttcgcaaaac ctattgacat
    19561 ttatttttga caagtgtaaa actttatgta agacaattgt caaaaaggag taaaatggga
    19621 tgagaaagat gaagaagctg cctgatgcgg aatttgacat tatgagggta gtgtgggcga
    19681 atgaaccgcc gattacgacc gccatgatta tggatcaact cgggaatgaa cgccaatgga
    19741 aggctccgac cgtcatttcc ctgatgatgc gtttggtcga acgggggttt ttgaagacgg
    19801 aaaaggaagg gaaggaacgc acgtattatc cgctcatacg caaagaagat tatctggcct
    19861 tagaaacgca acattttatg aagcagtatc acgaaaactc atttttaagc ttcgtgaata
    19921 ccttgtacaa cgggaagcgg cttacggaaa aagagttgga tgaattgttg aaatgggcca
    19981 aggaacggag ggagtagccg gtgcagggat ttatgattgc attgctggaa tgttcgatta
    20041 cgatgtccgt cattgccctt ctatatatgg cgattacccc gctgcttgcg aagacattta
    20101 cggcaaaagg acgttattat ggatggctgg tcatcatact cggattcatt attccgttcc
    20161 ggcttcatcc gcatgtctcg gtgattcgtc tcgatgcgct gctgcctgcg ctgaagatgt
    20221 cggacggcgg ctccgcccgc caagccgtgt ccgcagcggc ggcgtcatca gctattccgt
    20281 ggcaggccgt cgctggcggt ctgtggcttg caggagtcgt tgtatttctg gcctatcacg
    20341 ccattcggca ccggcgcttt ctgcaaatgg tgacacggtg gagcacggag attcgcgacc
    20401 ggcaagcgct acatatgctg catgatgttc aggcgaagct gggaataaga cagcaagtcg
    20461 ctttgcaagc ttgtcccggc atttccagtc cgatgctgct cggctttgtc cggccaacca
    20521 ttttgcttcc atccgacgac atcctctcag acgagcttcc actgattttt aagcatgagc
    20581 tggtacattt gaagcgaaga gatttgtggt ataaagcact tgtgctcgta gccgccgccc
    20641 tccactggtt caatccagtc gtctacgtca tggcaagaga catcgccctc caatgcgagc
    20701 tctcctgtga cgaagaagtg gtcaaaaaca cggatatcgc cggccggcaa caatatgtcg
    20761 aagccattat cgggatgcta aaaaaacagt ccgtagcgcc aaccatattt tccaccaatt
    20821 tttatggcag caagcaaggc ttgaaaaaca gggttctctc tatttggata ccagaagcaa
    20881 aaaatggggg atgcccattg ttgcgctcgt tattgcggcg acgctaagca cgggtacgct
    20941 gttaacgctg agcgcgccgt catcctatcc cgtccaaccc gcgcctctat cgaaggtgga
    21001 agcgggtccg atagagaagc ttccggtgaa tcatcctcct gaatcaactt ctccagtgca
    21061 tcacctcgaa gcaagtaagg acagatctgc ctctgagcat gagcttcttc ctaacaatgc
    21121 tgctccacga ttaatccagg gaaatcaaaa ggtggagatg gaggttccgg ctgctgaggg
    21181 acctaaatta atcaagatcg agtaatgacc cggcagaact ggcatgctca ggaatcaatt
    21241 ctttcttagt aaatcggctg gaaatttcga aggaggatga cattgtgaaa aaagcatggc
    21301 ttttcaggtt agtatcttgt ctgctcatcg tcgtcgtgtt ggcagcaggc tgctccaatc
    21361 cgaatccgac tccaaatccg ggcgaatcca atgccgccgg cgacggaaat cagaatccgt
    21421 ttgaagcggg taatgaggaa acggtcattc tgggcggtat cggtcacggg tttgtcaatc
    21481 cggacttaga tgagaacgga aaaatgcgtt ccttgcgcta cgatggcggt gagctaaaaa
    21541 ttccttattc cgtgaacgct tcgggaaaag ccaaaaatgt cggctttctc gtatttgtag
    21601 acgggatacc gcagccctat aaatttaaca caaccgatgc gccctatgaa tatatgcaca
    21661 tttttgagct ggaggaggat gataaggaca cgccgttcac attcgtgttc accccggtca
    21721 caggcaagaa gggggatacc ctgggcatca gcatcgccag catgtacaat ccgggcttta
    21781 tcccggatat gaaagagaca agctcgtacg gcggctatca cagtacgttg gaagcgggag
    21841 gaaccctgta ttttaacaaa gac
//
