LOCUS       NZ_CP041405            23585 bp    DNA     circular CON 07-APR-2024
DEFINITION  Paenibacillus thiaminolyticus strain NRRL B-4156 chromosome.
ACCESSION   NZ_CP041405
VERSION     NZ_CP041405.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6612542)
  AUTHORS   Hehnly,C. and Zhang,L.
  TITLE     Paenibacillus thiaminolyticus NRRL B-4156
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6612542)
  AUTHORS   Hehnly,C. and Zhang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2019) Institute of Personalized Medicine, Penn
            State College of Medicine, 500 University Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2018
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_Pthia_1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_007066085.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 14:58:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,886
            CDSs (total)                      :: 5,776
            Genes (coding)                    :: 5,673
            CDSs (with protein)               :: 5,673
            Genes (RNA)                       :: 110
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 52 of 103
            Pseudo Genes (incomplete)         :: 68 of 103
            Pseudo Genes (internal stop)      :: 17 of 103
            Pseudo Genes (multiple problems)  :: 28 of 103
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:43:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 480509
            Orig. end                         :: 504094
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP041405.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Schiff/Broach Lab 500
            University Drive Hershey, PA 17033
            Chromosome not circularized.
FEATURES             Location/Qualifiers
     region          1..23585
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23585
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23585
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13585](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13585
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            894..2003
                     /db_xref="GeneID:76994767"
                     /locus_tag="FLT43_RS02055"
                     /old_locus_tag="FLT43_02055"
     CDS             894..2003
                     /GO_function="GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994767"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012748953.1"
                     /locus_tag="FLT43_RS02055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02055"
                     /product="undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="WP_087443569.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 1.2e-22,
                     bitscore: 78.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 4e-26, bitscore:
                     90.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRRIVLTGGGSAGHVTANLVLISRLLEEDWDITYIGSKHGIERE
                     LVAGLKGVQYNPISTGKLRRYWAWANVTDLFKLMIGIIQAFLLIFRVKPGVVFSLGGFV
                     AVPVVVGAALNRVPVIILEPDLHPGLANRISRKFARAMCTTFRETVDNDGNADEKLVYA
                     GPIVREELKLGSRVRGMRLCSFFEDKPILLVMGGSQGAERINRAVREALRELLKSYQVV
                     HICGTGKTNAAYRRYEGYKQLEYAREELPDLMAMSDLVVSRAGSNAIHELVLLRKPMLL
                     IPHSIGGARTGQTLNAEHFKDAGYAEVLYETALTKEALLQAIDMTYRNQKSYVDRMKAS
                     KTDGAVDKVMALIEMAVKGKEGQGVEDFS"
     gene            1987..2343
                     /db_xref="GeneID:76994768"
                     /locus_tag="FLT43_RS02060"
                     /old_locus_tag="FLT43_02060"
     CDS             1987..2343
                     /codon_start=1
                     /db_xref="GeneID:76994768"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FLT43_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FLT43_02060"
                     /product="hypothetical protein"
                     /protein_id="WP_087443568.1"
                     /transl_table=11
                     /translation="MRIFPKVLLVAFSLLVLIFLMLAYNNELGSGKKSRQLECIMDQKT
                     TQLGHIRNSEYEDIILIVNDSTFNQIQLHDRYIGIFELNKVYGNNHGIVDMYDPQSIQV
                     EQSFDGYNSGCLGI"
     misc_feature    2459..2471
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            2578..3225
                     /db_xref="GeneID:76994769"
                     /locus_tag="FLT43_RS02065"
                     /old_locus_tag="FLT43_02065"
     CDS             2578..3225
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994769"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866097.1"
                     /locus_tag="FLT43_RS02065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02065"
                     /product="response regulator transcription factor"
                     /protein_id="WP_087443567.1"
                     /transl_table=11
                     /translation="MRILIADDEQDMLRILTAYFKKEGYEVFTAENGEEALDVFYREKV
                     DLSILDWMMPKQSGIEVCREIKARSDKKVLILTAKSEEEDELRALSIGADEYIRKPFHP
                     KILVLRAKRLLGDEKGLHYQSLRIDPEGNKIYKDGTDLHLTKMEFELMCCFVRHRGQIL
                     SRQQLLDLVWGLDYFGDPRTVDTHVRRLREKVGEDMIKTHRGLGYSVEAGDE"
     gene            3218..4609
                     /db_xref="GeneID:76994770"
                     /locus_tag="FLT43_RS02070"
                     /old_locus_tag="FLT43_02070"
     CDS             3218..4609
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994770"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="FLT43_RS02070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02070"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_087443566.1"
                     /transl_table=11
                     /translation="MNKLGRKLFISILVSVLLIFVMFVLLANLFMPKYYIYKTKEQLRE
                     AINTVNGLSEAEWIDAIPQIEQQYRVTIVYDDLQKQENDLNESLKQQLAKKRVTLNKFW
                     ITEESLLKVKAGTRINAIYDQGKLKSSFYASFIPKDETIVLIGLSMAYISDTVGMLNEF
                     ILILAFCSVLIIVFVVWLLSYRMTKPLKELGQVAKDISDLRFRKARVDTRDEIGELAES
                     INTMSDKLSAAHAELSRKNRSLKRFMSDMTHELKTPLSLIQAYAEGIQDGLDDGSYAAT
                     ILRHNQSMARLINEFLNFAKIERDELECKPVAVKDLFHECAAKFGIELKSRHLQLVIRD
                     ELPGNPQITADPNKIRMVFQNLLGNAVKYAAGERIDVVFEKQDAEMVLHMSNSLPREIT
                     DASRLWEPFYVEESSRHKEMSGTGLGLTIVKTILERHGFRCHAETKGQTIHFYLYFKVN
                     SPRSA"
     gene            4923..5594
                     /db_xref="GeneID:76994771"
                     /locus_tag="FLT43_RS02075"
                     /old_locus_tag="FLT43_02075"
     CDS             4923..5594
                     /codon_start=1
                     /db_xref="GeneID:76994771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226309.1"
                     /locus_tag="FLT43_RS02075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02075"
                     /product="lipoprotein BA_5634 family protein"
                     /protein_id="WP_087443565.1"
                     /transl_table=11
                     /translation="MRIIIHLCTIAALLFGFYFAYTFKEPRNGMLMIGEKEALQDIKNQ
                     HNADINSVDISKVKTMKNEGQSVFIMDQKTAQDVSKKGVLRKSDNDRGGASSDPIDSLP
                     TMINDEAILFSDNKNEKLKKMVLGDREIQIRYDSNTWLGHSRNSEYEDIILIVNPSTFH
                     QIPLQDTYIGIFELNKVYGNNHGIVDMYDRQSVQLEEEFTKLTKSKTNSAQLLEGLSIL
                     K"
     gene            5613..5984
                     /db_xref="GeneID:76994772"
                     /locus_tag="FLT43_RS02080"
                     /old_locus_tag="FLT43_02080"
     CDS             5613..5984
                     /codon_start=1
                     /db_xref="GeneID:76994772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929330.1"
                     /locus_tag="FLT43_RS02080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02080"
                     /product="hypothetical protein"
                     /protein_id="WP_087443564.1"
                     /transl_table=11
                     /translation="MAGIIGHTMVTTAAALAYKKQLNITTLFAGMAFPDIMTHLFVYIP
                     FIPGVSAGVLDETFLGGVACAIFLTLLVMLGLKTMPKAMYLFSYKQSTSLKVILLSALA
                     GTELHVLMDKIAINGWITF"
     gene            6351..7271
                     /db_xref="GeneID:76994773"
                     /locus_tag="FLT43_RS02085"
                     /old_locus_tag="FLT43_02085"
     CDS             6351..7271
                     /codon_start=1
                     /db_xref="GeneID:76994773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000791567.1"
                     /locus_tag="FLT43_RS02085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02085"
                     /product="hypothetical protein"
                     /protein_id="WP_115057887.1"
                     /transl_table=11
                     /translation="MKNKLIAAGIVTGALLLSPSHIFADSLSKVNTTFQYQIEENSVVG
                     EITDADTFYAVVEYKDSTGNIQTLDIDFPNESNKTFAIGDKVKVTNKDKWEVRDFGYFK
                     ATIAPGDFVSKLTDDSKSQNTNTQAEENYVIGEITDADTFYAVVEYKDSTGNIQRLDID
                     FPNESNKTFAIGDKVKVINKDKWEVRDFGYFKATIASGDFVSKLSDDSKSQNTNTQAEE
                     NYVIGEITDADTFFAVVEYKDSTGNIQRLDIDFPNESNKTFAIGDKVKVINKDKWEVRD
                     FGYFKATIASGDFVSKLSDDSKNGN"
     gene            8103..10004
                     /db_xref="GeneID:76994774"
                     /locus_tag="FLT43_RS02090"
                     /old_locus_tag="FLT43_02090"
     CDS             8103..10004
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994774"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419013.1"
                     /locus_tag="FLT43_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02090"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_087443561.1"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     6.5e-48, bitscore: 159.1, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="TIGR03693 (E-value: 4e-204, bitscore:
                     677.8, seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 5.2e-12,
                     bitscore: 44.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPSVRLKVKGDTFFLPDSNGGVYFRNNTGSFRMEGDMVDRWIEK
                     LMPMFSGEYSMADLTDGLPEPYRLRVYEIAEVLLNNGFVRDASQDRPHSLPEAVERQYA
                     AQIEFLDSLGGSGAYRFQTYREANPIAVGSGPIFVSLVAALLESGLPRFRMLITNRAAT
                     DRQRISELTATARLSDSEVEVEEICPSDDGSLDWPEIVRLADTVLYVAQDDDPGELRAL
                     HAACRDAKKLLVPAIYMRQAGIAGPLVHPDSDVCFESAWRRIHRIALGDADHPTAVSTT
                     AEAMLANVVVFEWLKTVSGATSELNGQLFLLNPETLEGEWHSVLPHPLVRGLRPAEPTD
                     PFCLPANQGTARQEADRLLSYFYRLTSAKTGILHRWEEGDSKQLPLSQCRVQAVDPLSE
                     GPAELLPQIVCMGMTHHEARREAGLAGIEAYVSRLAGELQEYVGIGAGETVAEAILRGL
                     RKCLFEELKSHSDSGLPSVYRITLSKVEDDFCRYCLRALETMQDAPVIGLGQEAAGFPV
                     VWVGTNGYWYGGVGVNRTMALREALRQALMTIQNDAADIQGHILERSSVKVEDALPQSL
                     TIPGFDESEYGMMLQSVRQILQGNRKRIAVVDLSTEPFMKEELAGVFGVSLREEETH"
     aSDomain        8106..8387
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FLT43_RS02090_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.10E-50"
                     /identifier="RREFam011.1"
                     /label="FLT43_RS02090"
                     /locus_tag="FLT43_RS02090"
                     /protein_end="95"
                     /protein_start="1"
                     /score="159.1"
                     /tool="antismash"
                     /translation="NPSVRLKVKGDTFFLPDSNGGVYFRNNTGSFRMEGDMVDRWIEKL
                     MPMFSGEYSMADLTDGLPEPYRLRVYEIAEVLLNNGFVRDASQDRPHSL"
     aSDomain        8115..8360
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FLT43_RS02090_Thiopeptide_F_RRE.1"
                     /evalue="2.50E-14"
                     /identifier="RREFam004.1"
                     /label="FLT43_RS02090"
                     /locus_tag="FLT43_RS02090"
                     /protein_end="86"
                     /protein_start="4"
                     /score="44.0"
                     /tool="antismash"
                     /translation="VRLKVKGDTFFLPDSNGGVYFRNNTGSFRMEGDMVDRWIEKLMPM
                     FSGEYSMADLTDGLPEPYRLRVYEIAEVLLNNGFVRD"
     gene            10001..11950
                     /db_xref="GeneID:76994775"
                     /locus_tag="FLT43_RS02095"
                     /old_locus_tag="FLT43_02095"
     CDS             10001..11950
                     /codon_start=1
                     /db_xref="GeneID:76994775"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419012.1"
                     /locus_tag="FLT43_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02095"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_087443560.1"
                     /sec_met_domain="TIGR03882 (E-value: 7.5e-46, bitscore:
                     154.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 2.3e-81, bitscore: 272.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.1e-129, bitscore:
                     430.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIVTVIGEGQLADFVMKLLSADDRYRLVWQKSIESGEAATGDL
                     ALVLNDAWDPSVHPAAEERFRQSGTPWLRGFVAFGEGIVGPLVRPEEQGCSQCADTRLL
                     LAGSDRREAWGLQQKLASHGGIARDAWASRTGLLQVAHLVAEEAVKILESVRPETDSRM
                     YLINLHTLQSSSHFFLPDPLCPICGRLPEDDAQLARIALQPSLKISAETYRSQSLDELK
                     DVLAKDYLDARTGFLNGQMVDLVSPFADASINLPLFGGDEACAGRTHSYADSEMTAILE
                     GLERYCGLSPRGKRTVVHDSFRNVQNRALDPLRVGVHAKEQYERSSFPFKPFDPERPID
                     WVWGYSFLQERPILVPELLAYYSAGCGHGFVYETSNGCALGGSLEEAIFYGMLEVIERD
                     SFLMTWYARLPLPRLDLRSVPDRELRWMTDRLEAVAGYDMYLYNSTMEHGIPSVWALAK
                     NKKERGVNLICAAGAHPDPIRAAKSAIHEVAGMLLTVSEKFEENRQQYERMLLDPYQVV
                     QMEDHSMLYGLKQAEERLDFLLNNDRPLQTFAEAFEPKGWNADLTDDLKAMLHVFRQLN
                     LEVIVVDQTTPETRRNGLYCVKVLIPGMLPMTFGQHLIRVTGLDRVLRVPAELSYSPEP
                     LSPEQLNPYPHPFP"
     gene            11993..13585
                     /db_xref="GeneID:76994776"
                     /locus_tag="FLT43_RS02100"
                     /old_locus_tag="FLT43_02100"
     CDS             11993..13585
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994776"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419011.1"
                     /locus_tag="FLT43_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02100"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_087443559.1"
                     /sec_met_domain="PF00881 (E-value: 3.9e-07, bitscore: 28.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLMNLDDFLHRLQYDPDKVKPLDWETDWDDAPLPYKLYRGLPMF
                     PLSREVPATLEGRDTPGVPSIRDIGHFLYYVYGLAQLTQSVMERDPSEESGGVLQMCRR
                     FVASGGGLYPSELYLYLKLGELPAGVYHYDAAHHRLALLREGNFEDFLARSLGHRSDVN
                     GCFGAAFVSTVYWKNFYKYNNIAYRLQGLDAGVLIGQLLEVAKRFGFSSGVHFQFLDQA
                     INHLLGLPEQEESVYAVIPLSTEPAIRWMESGSEGEDSVSASALCRELSPINHDHYVRS
                     RRIADYPLLLRMSDASRLDSTRLFRQIRQDEPALPDQALTLPLPPVDRLSYDLAAVCRN
                     RFSPETEFVLKPIGLSRLAALLREATASFTYRNDLDGLQERPEPRVCLYGCFYGVEDVP
                     DGAYRYDGAMHSLQSVCLGDHRQRMQEGMPLPNINLSQVPLCLHVAGKRGFFQSQLGKR
                     GYRIQQMEAGMLVHRLLLAASALGMGGRPLLAFDANSSDALYRTAFRDEAGLIFIPVGP
                     YRQRWRLTGSLSR"
     gene            complement(13674..14096)
                     /db_xref="GeneID:76994777"
                     /locus_tag="FLT43_RS02105"
                     /old_locus_tag="FLT43_02105"
     CDS             complement(13674..14096)
                     /codon_start=1
                     /db_xref="GeneID:76994777"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FLT43_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FLT43_02105"
                     /product="hypothetical protein"
                     /protein_id="WP_115057886.1"
                     /transl_table=11
                     /translation="MTYHQPFVQNPAGFQGSEPSEQALEQSIIQIRPRDDVFHESHSTW
                     HHIPHHHEHHPGMCHPWGDVMVHPWEHAHYPSMIHPFMHHPWDPHMDDLDPYLSSGWDC
                     CPVDYHHDWFHPCPWDHPHAHGHHSWDTHSWDTHHW"
     misc_feature    14304..14313
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     misc_feature    14365..14383
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.31"
                     /tool="antismash"
     misc_feature    complement(14369..14387)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.59"
                     /tool="antismash"
     misc_feature    14372..14390
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 28.36"
                     /tool="antismash"
     misc_feature    complement(14381..14399)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.17"
                     /tool="antismash"
     gene            14484..14816
                     /db_xref="GeneID:76994778"
                     /locus_tag="FLT43_RS02110"
                     /old_locus_tag="FLT43_02110"
     CDS             14484..14816
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994778"
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005550804.1"
                     /locus_tag="FLT43_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02110"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_174818236.1"
                     /transl_table=11
                     /translation="MNQIRQSILSGELRAGDSLPSIRQLAKDLQVSVITTKRAYEELEK
                     EELIDTVVGKGCFVSGANKEFIREQRMKRLEEKMLEIIQDSRELSMSQQDLIEHLTLLF
                     EEEQSP"
     gene            14813..15679
                     /db_xref="GeneID:76994779"
                     /locus_tag="FLT43_RS02115"
                     /old_locus_tag="FLT43_02115"
     CDS             14813..15679
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994779"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676098.1"
                     /locus_tag="FLT43_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02115"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087443555.1"
                     /transl_table=11
                     /translation="MNAIELRNLTKTYPEFTVDQVSLDVKQGYITGLIGPNGVGKSTLI
                     KMMIGLIRPDSGSVKILGCDMPNQEIDIKQRIGIVSDDCFYYEHLTIRDTKRMIAPFYK
                     KWNEKKFNSYLEQFELSPKKKIKDLSKGMKVKLSLAVALSHEAELLIMDEPTSGLDPVF
                     RRELLDLLADMMQDERNSIIFSTHITTDLDRIADYIAFINRGKLVFNEAKDEVLDRYAI
                     VKGDSQLLDSDIRNKFVGIRETAVGFEGLVDNRQEVAQLFGNYALLDKPTLEDIMYFTA
                     KGGRIHA"
     gene            15672..16298
                     /db_xref="GeneID:76994780"
                     /locus_tag="FLT43_RS02120"
                     /old_locus_tag="FLT43_02120"
     CDS             15672..16298
                     /codon_start=1
                     /db_xref="GeneID:76994780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676097.1"
                     /locus_tag="FLT43_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02120"
                     /product="ABC-2 transporter permease"
                     /protein_id="WP_087443554.1"
                     /transl_table=11
                     /translation="MLNLLRKDFIALKSSLWISILYLAVFGAFFIPKLSSSVHLVGIYT
                     AFSMLSLGTNIDIKNHNHNFLITLPVKRKHIIQAKYITAIIYTLFGVLASYGIHSLVKI
                     AVPELNKPNLTVMDILGPAAIVLALASIYLPLFYTLSKKGTSIINGVFFIALIALAQPT
                     AMFMNMIHVNGLHTDPILYLILIGILLLFIASCFLTAALFARKDL"
     gene            16353..17225
                     /db_xref="GeneID:76994781"
                     /locus_tag="FLT43_RS02125"
                     /old_locus_tag="FLT43_02125"
     CDS             16353..17225
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994781"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019392794.1"
                     /locus_tag="FLT43_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02125"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_087443553.1"
                     /sec_met_domain="Abi (E-value: 2.3e-08, bitscore: 32.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNKKWILLVLAGWSTLVVSLFLAGLAGEAANQLLGLSGNSRTFV
                     QGIVMSGLVVPIILYLYPHVYKITGVKSKPSVYSWKRLPHFMTGVLLAIALASLGFIIA
                     SSQGWVVIEKWHTPDQWFAALLTNVIVAFLFEALPEELGLRGMLYDLLRHRFAAWLAVL
                     FQIILFILVPMTATGLQVLFGLAPGNTINVFYVTLILSFGTCLQLLRLWTGSLWASIGF
                     HLAYLEIIRFVFSPHQYGGPIITFHESMPGLVGSITISMIIIGGIIVSLVILGAKRFIR
                     KSEGRHTTA"
     gene            complement(17411..18181)
                     /db_xref="GeneID:76994782"
                     /locus_tag="FLT43_RS02130"
                     /old_locus_tag="FLT43_02130"
     CDS             complement(17411..18181)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994782"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="FLT43_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02130"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_244194263.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.7e-11, bitscore:
                     41.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRLASLGYASLSLNKRGINGSEGNWLHQSIDDRVEEARQAIAW
                     AQQQPMIDEKRIGVWGASQAGWVIPKLAKKEPLAFSLLLSPAINWLSQGQYYTRIEMKN
                     DGYSEAEIQDKEAYDRQVRKLLEKQASYEEYVKIARENSLMSKDRWTFVSKNFLSDATD
                     DLRNFNTPVLLILGEEDLQVDVKETERVYRDIVKPELLTVAVFPDADHSMLSKQTAHSN
                     LRALFISLFTPRQITIPAYMDEIEQFLKKLPKHT"
     gene            complement(18182..18811)
                     /db_xref="GeneID:76994783"
                     /locus_tag="FLT43_RS02135"
                     /old_locus_tag="FLT43_02135"
     CDS             complement(18182..18811)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016742654.1"
                     /locus_tag="FLT43_RS02135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02135"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_087443552.1"
                     /transl_table=11
                     /translation="MTASRITIEPMQAKYNPQVSRLIVHGFRGKFQHLTSLSDEELALF
                     FEKLFDQFPAEAASRRIVALQEEQVIGTLSIKWNADSGKKQENRKLPSWRSFHSIGTWD
                     FLKLLIGLSLLDHQPQAGECYIADVAVHPDHRSKGIGKMLLEWAQQLVHAEPSLNMLSL
                     HVSGKNPRAKHLYEQLSFYTHSQGNSIMRHFLFNERKWHYMILRLK"
     gene            complement(18824..19597)
                     /db_xref="GeneID:76994784"
                     /locus_tag="FLT43_RS02140"
                     /old_locus_tag="FLT43_02140"
     CDS             complement(18824..19597)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994784"
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015891166.1"
                     /locus_tag="FLT43_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02140"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_087443551.1"
                     /transl_table=11
                     /translation="MKSEITISELAKLMNVSAHQIRYFEEKGVLQPSYTDNNQYRMYGI
                     EQVYELAHILLLRKLGVPVPSIKECMTSFTADQFRQLLHSSLREIEMELQRLMELQQFI
                     TKVLQEQHNVTAQSNPYQIKRRDTTYFVRWMEMDFHTKLTATRLADHTKRIPNLFEMDI
                     HYIYDGSHINALCLEVQEPGDFALPEGDYLSMQCSIQEEDELEQVIEQFYDYAAAQSYV
                     ISGPLVLIEKSYLSLFINNKVQYELQVLIEPVTNP"
     misc_feature    19692..19707
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     misc_feature    19726..19741
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            19773..20171
                     /db_xref="GeneID:76994785"
                     /locus_tag="FLT43_RS02145"
                     /old_locus_tag="FLT43_02145"
     CDS             19773..20171
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:76994785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010503053.1"
                     /locus_tag="FLT43_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02145"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_087443550.1"
                     /transl_table=11
                     /translation="MEKMPKISESEWEIMKVIWRKNPMTAEQIVQHLPEGTDWSDQTVR
                     TFINRLMKKKALGYQKSGRSYLYYPLISEKECVRAESRSFLNRVFNGAAGLMMTNFLEE
                     TQLSEQEIERLQQILLEKQGKESKDSKD"
     gene            20216..22465
                     /db_xref="GeneID:76994786"
                     /locus_tag="FLT43_RS02150"
                     /old_locus_tag="FLT43_02150"
     CDS             20216..22465
                     /codon_start=1
                     /db_xref="GeneID:76994786"
                     /inference="COORDINATES: protein motif:HMM:NF017390.4"
                     /locus_tag="FLT43_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02150"
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_087443549.1"
                     /transl_table=11
                     /translation="MDIAERLFNWFVASTLMASAVAVVVLAVQHLFRRRIHARVRHALW
                     LIVLLRLMLPVLPQSPVSLFNAVPALTDIKNAVFGLSYQLGKPDTISEHSQIENTYQPY
                     YTTNEAETNTVFHPFVTLKDTEEHAEAGIERESHPAFRVLAVVWLTGAAVLLGYNLTYW
                     LRFRRKQKHLTPVDSAAIWKIAEQCRLLFSIKRPVGIYADPSAQSPYITGVFRPAVYLP
                     QSLISEAVNEQLLKHIIAHELAHYKRKDTIWNMIGSLVFAVHWMNPFVWFMLRQMKADR
                     ELACDACVLEALGEEEAVPYGMTIIGFLRRYAAGRGQAHLLYFKGSNDQKEMMRRIRMI
                     QSFKKGSYKFSMMAVILVLLIGTATLTNARASEAGASAWVHAEDGGNEMLFPSEEIRSY
                     DNLEKGAKEAPFTFKVPSWLPEGYGFRGLSITFNDSPPRVGLSFTETKSKSSGNFGLSI
                     WPGDELQKQNDLIFSIEQDEDSGKVIEKEALSLAGIDEGYKITIRMTTWKGQPERYYYI
                     WKDQGLSYELSSHILSSNEMEKIIASMKFPDAELNKLHVDNDYHDKILTYLYDIEDIRR
                     AQELVGFKAAFPRKLPGDFAASDSYVSRKANFNHVENDEDSMRKMFSVTYSRGDRNQKN
                     KADSGIKDVSFKQMLNGDMYQKMKKNGRVSFSIISGERNSIKLKALTLQGQEVLRTEPY
                     NLDGTPKGPDDLSLVSYFWFDGQVCYQVVFQGKGAYQGKGAEEQKIVQYLMKPDR"
     gene            22680..23078
                     /db_xref="GeneID:76994787"
                     /locus_tag="FLT43_RS02155"
                     /old_locus_tag="FLT43_02155"
     CDS             22680..23078
                     /NRPS_PKS="Domain: Polyketide_cyc2 (7-100). E-value:
                     4.5e-13. Score: 41.8. Matches aSDomain:
                     nrpspksdomains_FLT43_RS02155_Polyketide_cyc2.1"
                     /codon_start=1
                     /db_xref="GeneID:76994787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003390153.1"
                     /locus_tag="FLT43_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FLT43_02155"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_087443548.1"
                     /transl_table=11
                     /translation="MSLTLSLDFQFTASIEKVWSALTDSSKLAKWIMENDFKPDVGHRF
                     QFRTQPTEWWNGIIEGEVLIVDAPHRLSYTWASGGEKHTVTWTLQDVGDGKVNLHLEQT
                     GISTAQGLEGAKYGWSGWCGELEKVLEQ"
     aSDomain        22701..22979
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FLT43_RS02155_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.50E-13"
                     /label="FLT43_RS02155_Polyketide_cyc2.1"
                     /locus_tag="FLT43_RS02155"
                     /protein_end="100"
                     /protein_start="7"
                     /score="41.8"
                     /tool="antismash"
                     /translation="DFQFTASIEKVWSALTDSSKLAKWIMENDFKPDVGHRFQFRTQPT
                     EWWNGIIEGEVLIVDAPHRLSYTWASGGEKHTVTWTLQDVGDGKVNLH"
     misc_feature    23519..23535
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
ORIGIN
        1 ccaaaagaga tccgtatatt ctcccgcaat gaatcactgc aagttcaaat gcgccatcaa
       61 tttgaggatc ctagattgcg attcgtgatt ggcgatattc gagataaagc ggaattggtc
      121 atggcgtgca gcggtgtaga tgaggtatat catctagcgg cgctgaaaca tgttccgatc
      181 tgtgaggagc agccggagag tgcgctcaaa acaaacgtaa tgggaacgca aaatgtgatc
      241 gaggcggcaa tcgaaaatgg cgtccgaaaa gtaatgtatg tttccacgga taaagcagcc
      301 aaccctgcaa atatctatgg tatgacgaaa gcgatcggag agaagcttat cttatgcgca
      361 aatggaagat cggaaacaag gtttgtaagt tttagaagcg gcaatgtgct cggaacggcg
      421 ggaagcgtag tgcccttatt caaccagcaa ctcaaagagg ggagggatct cagtgtaact
      481 gctccgggaa tgacgcgttt ctttctcact gtggaggacg ccgtccaaat cttggtgaca
      541 gcgatggaga acagcctcgg aggcgaaata ttcgtcccga agatgggagc ttgcagaata
      601 acggatcttg cgcaagcgtt aatcaatcat tctaagtcaa aacatgccaa aattcactac
      661 gtaggcattc gttcgggaga aaggcttcac gagacgttga ttacggaatc ggagagcagc
      721 cgggtgaatg aaagtcatga acgatatttt atgatcatgc cagacttcca aagtgacttg
      781 ttggcggtgg acgaagtgca tcgaggcaat atgcgtagag gatatcattc agaggattgt
      841 atgatgtcac tcgatgagat tggacaactg cttcggaaag gcgggtttgt ggaatgaaac
      901 ggagaattgt attgacggga ggcggatcgg ctggtcacgt tacagcgaat ctagtactga
      961 tttcccgttt gttagaggaa gactgggata tcacttacat cggctccaag cacgggattg
     1021 agcgcgaact ggttgccgga ctcaagggcg ttcagtacaa cccgattagt acggggaagc
     1081 taagacgata ttgggcatgg gcgaacgtaa cggatctgtt taagcttatg attggaatta
     1141 tacaggcatt tctgctcatt tttcgagtca agccaggtgt tgtgttttcc ttgggcggct
     1201 tcgtcgcggt accggtcgtg gttggtgccg ctttgaaccg agttcccgtt attattctgg
     1261 agcccgatct acatcccggg cttgcgaatc gtatctcccg caagttcgct cgagcaatgt
     1321 gtacgacctt cagggaaacg gttgacaatg acggtaacgc tgatgagaag ttggtgtatg
     1381 ccggtccgat cgtaagggag gaactgaagc tgggcagccg cgttcgcggc atgcgtctct
     1441 gcagcttctt cgaggataag cccattcttc ttgtcatggg agggagccaa ggagcggagc
     1501 gaatcaaccg tgccgtcagg gaagcactcc gagagctctt aaagagctat caagtggttc
     1561 atatttgcgg aactggaaag acaaatgctg cttatcggcg gtatgaaggt tataaacagc
     1621 ttgagtatgc ccgcgaagag ctcccggatc taatggcaat gtcagatctt gtcgtgtcga
     1681 gggcgggttc aaatgcgatc catgaactgg tgcttctgcg aaagccgatg cttctgattc
     1741 cacattctat cggtggagca cgaacaggac aaaccttgaa tgcggaacat tttaaggatg
     1801 cgggctatgc agaggtactt tatgaaacag ctctcacgaa agaagcctta ctgcaagcca
     1861 tagatatgac ttatcgtaat cagaaatcgt atgtggatag gatgaaggcc agcaagacgg
     1921 atggggctgt agacaaggta atggcactca ttgagatggc ggttaaagga aaggaggggc
     1981 agggagttga ggatttttcc taaagtttta cttgttgctt tcagtctact cgtcctgatt
     2041 tttcttatgt tggcttataa taatgaactc ggaagcggga aaaagagtcg tcaattggaa
     2101 tgcatcatgg atcagaaaac aacgcagctt ggacatatcc gcaattcgga gtatgaagac
     2161 atcatcttaa tcgtaaacga ttctacattt aatcagattc aattgcacga cagatatatc
     2221 ggaatttttg agctcaataa agtgtatggg aataatcatg gcattgttga tatgtacgat
     2281 ccgcaatcca ttcaagtcga gcagtcattc gatggttaca atagcggctg ccttggcata
     2341 taagaaacaa ttaaacataa ccactttatt tgcaggaatg gcgtttcctg atataatgac
     2401 tcccgtcttt gtttacattt aagcaaagca cttccttgaa agtcataaga ttgttacgat
     2461 gcaagttgca aatttgctcg ttaacacaag ataacttatc aaaaaaaaga actatattat
     2521 ggttaaaaat gaatttttaa ggaattaaga ggcaatttag cacaaaggga gattgctatg
     2581 cggatattaa ttgcggacga tgaacaggat atgctccgga ttttaacggc gtatttcaaa
     2641 aaggaaggat acgaggtatt tacggccgaa aacggcgagg aagcattgga tgttttttat
     2701 cgcgagaagg tcgatctttc tatcctggat tggatgatgc cgaagcagag cgggatagaa
     2761 gtttgccggg aaatcaaggc tcggtcggac aaaaaagtgc tgattttaac agcaaaaagc
     2821 gaggaagaag atgaactgag ggcgctcagc atcggtgcgg acgaatatat ccgtaagccg
     2881 ttccatccga agattctcgt tctccgggcg aaaaggctgc tgggcgacga aaagggactg
     2941 cactatcaat cactgcgaat cgatccggaa ggcaataaaa tatataaaga cggcacagat
     3001 ctgcacttaa caaaaatgga attcgagctt atgtgttgtt ttgtccgcca taggggccag
     3061 attctgtcac gtcagcaact gctggacttg gtgtggggac tcgattattt cggcgatcca
     3121 agaacggtgg atacccatgt acgcaggctg cgggagaagg tgggcgaaga catgatcaaa
     3181 acgcaccggg gacttggata cagtgtggag gcgggcgatg aataagctgg ggcgtaagct
     3241 gtttataagc atcttagtct ccgtcttgct cattttcgtc atgtttgtgt tgctggcgaa
     3301 cttgtttatg ccgaaatact atatttacaa aacgaaagaa cagctcaggg aagcgataaa
     3361 tacggtaaac gggctttcgg aagcggaatg gatcgatgca atcccgcaga ttgagcaaca
     3421 ataccgcgtg acgatcgtgt atgatgattt gcagaaacag gaaaatgacc taaatgagtc
     3481 gctcaagcag cagcttgcga aaaagagggt gaccctaaac aagttctgga ttacggaaga
     3541 atcactcttg aaggttaaag caggtacccg gataaatgca atatacgatc agggcaagct
     3601 caaatccagc ttttacgcaa gttttatccc aaaggacgaa accattgtcc tgatcgggct
     3661 ttcgatggcc tatatcagcg atacggtcgg gatgctgaac gagttcatct tgatcttggc
     3721 cttttgttcg gtgctgatca tcgtatttgt tgtctggctc ttgtcatatc ggatgaccaa
     3781 gccgctcaaa gaactgggac aggtagcgaa ggacatatcg gatctccgtt tccgaaaagc
     3841 ccgggttgat acccgggatg aaatcggtga gctggcggaa agcattaaca cgatgagcga
     3901 caagctgagc gcagcgcatg ccgaattatc caggaaaaac cggagtctga agcggtttat
     3961 gtcggatatg acacatgagc tgaaaacgcc gctttcgctc attcaggctt atgccgaggg
     4021 gattcaggat gggttagacg atggaagtta cgctgccacc attttgcgtc acaatcaaag
     4081 catggcaagg ctgattaacg agtttttgaa ttttgcgaaa attgaaaggg acgaacttga
     4141 atgtaagcca gttgccgtga aagatttgtt ccatgaatgt gccgcaaaat ttggcattga
     4201 gctcaagtca aggcatttgc agttagtgat tcgcgatgag ctgccaggta atcctcagat
     4261 tacagcggat ccgaacaaaa tccggatggt ttttcagaac ctgctcggca atgcggtgaa
     4321 atatgcggcc ggcgaacgga tcgatgtggt tttcgagaag caggatgccg aaatggtgct
     4381 gcatatgagc aacagccttc cgagagagat cactgatgca tctcgattgt gggagccctt
     4441 ttacgtagag gaaagctcgc ggcataaaga aatgtcggga acgggtctcg ggcttacgat
     4501 tgtcaaaaca attctggaaa ggcacggctt ccgctgccat gcggagacaa aaggacaaac
     4561 gattcatttt tatctctatt tcaaggtgaa cagcccccga tctgcgtaaa cagatggagg
     4621 gcttgataaa atcctatttc acgagcatgt tttcatattt cttcgcttcg tcggactttt
     4681 catcgaatgg atggtcttgt gggaagggac cgacccatac gtaattagcg ttttcgccaa
     4741 tttttcgccc ataggttctc catctcgagg aaatgtctta tcatcgtacg ctcggcagca
     4801 tgaaacaatg aggcacagat cttacaccgc tgtcattaaa atgtaagcga actcgatagg
     4861 ataaatcatt tacagatgct aaattaaagt aaataaacat gatcaacaaa tggagcaaaa
     4921 acatgcggat aataattcat ttatgtacga ttgcagcgct tttattcggt ttctacttcg
     4981 cttatacatt taaggaacca agaaacggaa tgctaatgat aggagagaaa gaagcattgc
     5041 aagatatcaa aaatcaacac aatgctgaca tcaattcagt ggacatctct aaagtgaaaa
     5101 caatgaaaaa tgaaggtcaa tcggtattca tcatggatca aaaaacagcg caggatgtga
     5161 gcaaaaaagg ggtattgcga aaatccgata atgaccgggg gggtgcgtct tccgatccaa
     5221 tcgattcctt acctacaatg atcaatgatg aagccatctt gttctcagat aacaagaatg
     5281 aaaagctaaa gaaaatggta ctgggcgata gagaaatcca aatcagatac gacagcaata
     5341 cctggcttgg tcatagccgt aattcagagt atgaagacat cattttaatc gtgaacccct
     5401 ctacttttca tcaaattcca ttgcaagaca catatatcgg aatttttgag ctcaataaag
     5461 tgtatgggaa taaccatggc attgttgata tgtatgatcg ccagtcggtt caactagagg
     5521 aagaatttac gaaacttacg aagagcaaga caaatagtgc ccagcttcta gaaggactat
     5581 cgatactaaa ataattaaaa tgggggttga atatggctgg aattataggt cataccatgg
     5641 ttacaacagc tgccgccttg gcatataaaa aacaattaaa catcacaact ttatttgcag
     5701 gaatggcctt tcctgatatt atgactcacc tattcgtgta cattccattt attcctggcg
     5761 taagtgcagg tgtcctggat gaaacttttt taggcggtgt ggcctgcgcc atcttcttga
     5821 ctctgctggt tatgctgggt ctgaaaacaa tgccgaaggc aatgtattta ttttcttata
     5881 agcaaagcac ttcgctcaaa gttattttgt tgtctgccct cgcaggtact gaattacatg
     5941 tactcatgga taagattgct atcaacggtt ggataacttt ctgattacat ctatatagtt
     6001 gaatatgaaa ctcccgcggc tgcagtattt cgcgggagtt tttcttcgat attatttacc
     6061 tgatatacaa attactttct atattattaa ttcttacctt acaaaagtgt aataattttt
     6121 ttgttgacgc tccttagttg ttgtaactat actggttaca agagttggta tatattagtt
     6181 tcttgctata ggtatatgtc agttgattct tttcgaatca atggtttaat taagcaacta
     6241 gtatgcagta attacaccaa ctcactatat ttctcattaa gctagggcat attcccttga
     6301 ttctaatata cttaccaact cttaaaactt acttagaggt gacaacgttg atgaagaata
     6361 aacttattgc agcaggaatt gttacaggag ccttactatt atctccatct catatttttg
     6421 cagactctct ttctaaagtg aataccacgt tccaatatca aatcgaagaa aactctgtag
     6481 tcggcgaaat aaccgatgca gataccttct atgcggttgt tgagtataag gattctacag
     6541 gaaacattca aacgctagac atcgactttc cgaatgaaag caacaagact tttgcaatag
     6601 gcgacaaagt taaagttacc aataaagaca aatgggaagt aagggatttc ggttacttca
     6661 aagcgactat agcccctgga gattttgtgt ctaagctgac tgacgactca aagtctcaga
     6721 acacaaacac acaagcggaa gaaaactatg taatcggcga aataaccgat gcagatacct
     6781 tctatgcggt tgttgagtat aaggattcta caggaaacat tcaaagacta gacatcgact
     6841 ttccgaatga aagcaacaag acctttgcaa taggcgacaa agttaaagtt atcaataaag
     6901 acaaatggga agtaagggat ttcggttatt tcaaagcgac tatagcatct ggagattttg
     6961 tgtctaagct gtctgacgac tcaaagtctc agaacacaaa cacacaagcg gaagaaaact
     7021 atgtaatcgg cgaaataacc gatgcagata ccttctttgc ggttgttgag tataaggatt
     7081 ctacaggaaa cattcaaaga ctagacatcg actttccgaa tgaaagcaac aagacctttg
     7141 caataggcga caaagttaaa gttatcaata aagacaaatg ggaagtaagg gatttcggtt
     7201 atttcaaagc gactatagca tctggagatt ttgtgtctaa gctgtctgac gactcaaaaa
     7261 acggaaacta aaaagcaaac ataccgcata tttcgcggta tcagcctgtt gagaaatcct
     7321 caatggcaag agcgaactcc gtagcatacg gccatatact aaaaaaggga aagctgtcga
     7381 ttgatattgg ctgcttttcc ttttttatat atacgattcc gaaaggactt gaaattcagg
     7441 accgacagcc cgaaacgtaa cagtgaaatt cagttattag ggctccctgc cttaaccgtt
     7501 ttttgggtgg gctgatgtca taggaacact agcggagcga atttcataag atatctcgtc
     7561 aagattgagg atgagcagct tgccggtcgg gcccggatcg gaacattctc atttaacgaa
     7621 tcacatgcag ggtcagtgaa atgaatgata cggagggtat aaaatgagcg attttcagaa
     7681 ggatctgcaa aacttgaatg tcggccagtt cagttcgacg gggatgacgc ctgcgtcggg
     7741 gcaaaatcca agcggcccgg gtgatccccg cttatgtgtt ggcgtttgct ttttttgcgc
     7801 cggcttttgc ggcggatttt gttcctgcgg caactgtttc cgctgcagca gctgcttccg
     7861 ctgcggtggc tgcgcgcgtt gcggaagctg cgctcgctgc cgctgagtac cgataagctc
     7921 gcttggcgaa ccgcaaaaac gggatgcccc tgcagatgta tcgtcctgca ggggctgttc
     7981 ctatttttcg ttccaggcat gaaggacaaa acgctctaca taacttaaaa gcggggggaa
     8041 accgaagtcc tgcgtacgat gcggtttttc ctccggcaaa accttaagga ggaataaaaa
     8101 acttgaatcc ttctgtgcgt ctgaaagtga aaggggatac gttctttctc cccgattcaa
     8161 atggcggcgt ctacttccgc aacaatacgg gttcgttccg aatggaaggc gacatggtcg
     8221 accggtggat tgaaaaattg atgcccatgt tcagcgggga atattccatg gcggatctga
     8281 cggacggatt gccggaaccg tacaggttac gggtttatga aatcgcagaa gtactgctca
     8341 ataacggctt tgtccgggat gccagccaag accgcccgca cagcctcccg gaagcggtag
     8401 aacggcaata tgcagcacag atcgaattcc tggacagctt gggcggttcg ggcgcttacc
     8461 gcttccaaac ctatcgcgag gctaatccga ttgcggtcgg ttccggtccg atatttgtct
     8521 cactcgttgc ggccttgttg gaatccgggt tgccccggtt tcgcatgctg atcacgaacc
     8581 gggcggccac ggatcgccag cggatctccg agcttacggc gactgcacgt ctatcggaca
     8641 gcgaggtcga ggtcgaggag atctgtccgt cggatgacgg ctccctcgat tggccggaaa
     8701 tcgtccggct ggcggatacc gtcctatacg tcgctcagga tgacgatccc ggagagctta
     8761 gagcactgca cgcggcctgc agggacgcga agaagctgct ggtacctgcc atctacatgc
     8821 gacaggcggg catagcaggg ccattggtgc acccggattc ggacgtctgc ttcgaatccg
     8881 catggcgcag gattcaccga atcgccctgg gcgatgcaga tcacccgacc gccgtctcta
     8941 ctacggcgga agccatgctc gcgaatgtgg tcgtattcga atggcttaag accgtgtcgg
     9001 gggccacttc ggaattgaac ggacaactgt tcctgctgaa tccggaaaca ttggaaggcg
     9061 agtggcattc ggtgcttccc catccgctgg tcaggggtct tcgtccggcc gagcctacgg
     9121 atccgttctg ccttccggcc aatcaaggta cggcgcggca ggaagcagac cgtctcctct
     9181 cctatttcta ccgcttgact tcggcgaaga ccggcattct tcaccgatgg gaggaagggg
     9241 actcgaagca gcttccgctc tcgcagtgtc gcgtccaggc agtcgacccg ctgtcggaag
     9301 gccccgccga gctgctgccg cagatcgtct gtatgggaat gactcaccat gaagcaagga
     9361 gagaagcggg cttggccggc atcgaggcgt acgtgtcgcg gctggccggg gaactacagg
     9421 aatatgtagg gatcggagcg ggagagaccg tagcggaagc gatcctccgc ggactgcgga
     9481 aatgtctgtt cgaggagttg aaaagtcatt ccgattccgg cctgccctcc gtgtatcgaa
     9541 tcacattaag caaggtagag gacgattttt gccgctattg cttacgcgca ttggagacga
     9601 tgcaggacgc cccggtaatc ggactgggac aagaagcggc gggctttccg gtcgtctggg
     9661 tcggtacgaa cggttactgg tacggcggcg tcggagtcaa ccgcacgatg gcgctgcggg
     9721 aagcgctccg gcaggcgctg atgacaatcc aaaacgatgc agcggacatc caaggtcaca
     9781 tactggagcg ctcttcggtc aaggtggaag atgccttgcc gcaaagtctg acgatccccg
     9841 gcttcgatga gtcggaatac gggatgatgc tgcagtcggt ccggcagatc ctgcaaggga
     9901 accgtaagcg aatcgcggtc gttgatttgt ccacagaacc gttcatgaaa gaagagctgg
     9961 caggcgtgtt tggcgtatcg ctgcgagagg aggagacgca ttgagcgcga tcgtgacggt
    10021 catcggagaa ggacagctcg cggattttgt aatgaagcta ttgtctgcag atgaccgcta
    10081 tcggctggtc tggcagaaga gcatcgaatc cggagaagcg gcaacgggag acttggcgct
    10141 cgtgttaaat gatgcttggg atccttccgt tcatcctgcg gcggaggagc ggttccgaca
    10201 gtcgggaacg ccctggctgc gcggctttgt tgcattcgga gaggggattg tcggtccgct
    10261 ggttcgtccg gaggaacaag gatgctcgca atgcgcggat acccggctcc tgctggcggg
    10321 aagcgaccgc agggaagcgt ggggcctgca gcagaagctg gcttcgcatg ggggaattgc
    10381 ccgggacgct tgggcgtctc gcacgggatt attgcaggtg gcgcaccttg tcgcggaaga
    10441 agccgtgaag attctagaga gcgtgcggcc ggagacggac agccggatgt acttgatcaa
    10501 tctgcatacg ctgcaaagct cgtctcactt cttcctcccc gatccgctgt gtccgatctg
    10561 cggccgattg ccggaagacg atgcgcagtt ggcccgcatt gcgctgcagc ctagcctgaa
    10621 aatcagcgcc gagacgtatc gcagccagtc gctagatgag ctgaaggatg tgttggccaa
    10681 agactacctg gatgccagga ccggttttct gaacgggcaa atggttgacc ttgtgtctcc
    10741 tttcgccgat gcgagcatca atttgccctt gttcggcgga gatgaggctt gcgcaggccg
    10801 gacccactcc tatgcggata gcgaaatgac ggccatcctg gagggattgg agcgttattg
    10861 cggtctgtcg ccccggggca aacgaaccgt cgttcatgac agtttccgca atgtacagaa
    10921 ccgggcgctc gatcctctcc gcgtaggcgt ccatgcgaag gaacagtatg aacgatccag
    10981 cttcccgttc aagcccttcg atcccgaacg gccgatcgat tgggtatggg gctattcgtt
    11041 cctgcaggag cgtccgattc tcgtaccgga gctgctggcc tattacagtg cgggctgcgg
    11101 acacggcttc gtctatgaaa cgtcaaatgg ctgcgcgctg ggcggcagtc tggaggaagc
    11161 gatcttctac gggatgcttg aagtgataga gcgcgactcc tttctcatga cctggtatgc
    11221 gcggctgccc ctgcctcgcc tggatctccg ctcggtcccg gaccgggaat tgagatggat
    11281 gacggatcgt ttggaggctg tggcgggcta tgacatgtat ttgtataatt cgacaatgga
    11341 gcatggcata ccaagcgtgt gggcgctcgc gaaaaacaag aaagagcggg gcgtgaacct
    11401 catttgcgcg gcgggcgccc atccggatcc gatacgcgcg gcaaagagcg cgattcacga
    11461 ggtggcgggc atgctgctca cggtcagcga gaaattcgag gagaaccgtc agcagtatga
    11521 acggatgctt ctcgatccat accaggtcgt tcagatggag gaccactcca tgctgtacgg
    11581 gttgaagcag gcggaggaac ggctcgattt tctgttgaat aacgatcgtc cgctacaaac
    11641 gttcgccgaa gcgtttgaac cgaagggctg gaacgccgat ctgaccgatg atctgaaggc
    11701 catgctgcat gtttttcgac agttgaatct tgaagtgatc gtggtcgacc agacgactcc
    11761 ggagacgcgc cgcaacggac tgtattgcgt gaaagtactc attcccggca tgctgccgat
    11821 gacgttcggg cagcatctca tccgtgtgac gggactggat agagtgctca gggtccctgc
    11881 ggagctgtct tattcgccgg agcccttgtc gcccgagcag cttaatccat atccgcatcc
    11941 gttcccataa ttacgctatg gggcggggcg gttgaagcca gggaggaaag cgatgagtct
    12001 gatgaatctg gacgattttc ttcaccgttt gcaatatgat ccggataagg tcaagccctt
    12061 ggattgggag acggactggg atgacgcgcc tcttccttac aagctttatc gcggcttgcc
    12121 gatgtttccg ctatccaggg aagtgccggc aacgctcgaa ggcagggata cgcccggtgt
    12181 gcctagcatc cgcgatatcg gacacttcct ctactatgta tacgggcttg cgcaattgac
    12241 ccaatccgtc atggaacggg atccctcgga agaatcggga ggcgtcttgc aaatgtgccg
    12301 gcgcttcgtt gcttccggag gcgggctata tccgagcgaa ctgtatcttt atcttaagct
    12361 tggcgaattg cctgccggcg tataccatta cgatgcggcg catcatcggt tggcgttgct
    12421 gcgcgaaggg aatttcgaag attttttggc gaggtcgctc ggtcatcgca gcgacgtgaa
    12481 cggttgcttc ggagccgcgt tcgtatctac cgtttactgg aaaaactttt acaaatataa
    12541 taatatcgcc taccggttgc agggactgga cgccggcgtc ttgatcggac agctgctcga
    12601 agtcgcaaaa cgattcggat tttcgtccgg cgtgcatttt caatttctcg atcaagccat
    12661 caaccatctg ctcggactac cggaacagga ggagagcgtg tatgcggtaa tcccgttatc
    12721 gacggaaccc gcgatccggt ggatggaaag cgggagtgag ggggaggact cggtttccgc
    12781 ctccgctctg tgccgggagt tgtcgccaat caatcatgat cactatgtca ggtcgcggcg
    12841 gattgcagat tatccgctgc tgcttcggat gagtgatgcg tcccgactgg attcgacgcg
    12901 attgttccga cagatccggc aagatgagcc agcactcccg gatcaagcgc tcacactgcc
    12961 tctgccgcct gtagaccgct tgtcgtatga tctggcggcg gtgtgccgga accggttctc
    13021 gcccgagacg gaatttgttc tgaagccgat cggtctctcc cggcttgccg ctctgcttcg
    13081 ggaagcgacg gcttccttca cgtatcgcaa cgacctggat ggcctgcagg agcggccgga
    13141 accccgtgta tgcctttatg gctgcttcta cggggtcgaa gacgttccgg atggcgccta
    13201 tcggtacgat ggtgccatgc attcgctgca gtcggtgtgc cttggagatc accggcagcg
    13261 gatgcaggag ggaatgccgc ttcccaatat caatttgtct caagtcccgc tctgtttgca
    13321 tgtggcaggg aagagggggt tcttccaatc gcagctcggc aagcggggat accgtataca
    13381 gcaaatggag gcggggatgc tcgtacaccg gttattgctg gcagcatccg ccctcgggat
    13441 gggagggcgt ccgcttctcg cgtttgacgc caattccagc gatgcgcttt atcgaacagc
    13501 tttccgggat gaggcggggc tgatttttat accggtcggt ccctatcgtc aacgatggcg
    13561 cttgacgggc agtttgagcc gttaaaataa atgaaacatc gctaacaaca ttgacgcaaa
    13621 cggtcatgtt gttagcgatg ccccccattc aagcaaggga gaccggaatt ctcttaccaa
    13681 tgatgggtat cccacgaatg ggtatcccac gaatgatggc catgcgcgtg gggatggtcc
    13741 catggacatg gatggaacca atcatgatgg tagtcgaccg ggcagcaatc ccaccctgaa
    13801 gacagataag gatcaaggtc atccatatgc ggatcccatg gatgatgcat gaagggatgg
    13861 atcatggacg gataatgagc atgctcccag gggtgaacca tcacgtcccc ccaaggatga
    13921 cacatcccgg gatggtgttc gtgatgatga ggaatatggt gccaggtaga atgggactcg
    13981 tgaaacacgt catcgcgagg tctaatttga ataatcgact gctcgagtgc ttgctcggac
    14041 ggctcggaac cctggaagcc ggccgggttc tgaacgaaag gttgatggta cgtcatggtt
    14101 ggttttcctc ctaatcttgt gaggggcaaa gcattgttaa ccctcttctg gcaaatctcg
    14161 atttggaagc cttcgcttgc ataatttaca atatgctgaa attgaaaaaa gggcacttga
    14221 ccctataaaa tgggcaggtg ccccaatgcc gcgtaatatg cggctttttg tatgattagg
    14281 ccaatcagaa tttctggctg gtttattttt ttaggaatat aaagatggcg gtgagcaatg
    14341 gtttcacatt tttcaattga cgcaaaagtg aatagtgtat atagtatata tatacggtat
    14401 gcaccccatt gacagcagcg aggtgaggga acctgaacat catcatatcc aacgcgtcga
    14461 gcgacccgat atacatacag atcatgaacc agataagaca gagcatcctg agcggtgaat
    14521 tgcgagcagg agacagcctt ccttccatta gacagcttgc caaggatctg caggttagtg
    14581 ttatcacgac caagcgtgcc tatgaagagt tggagaaaga ggagctaatc gacactgttg
    14641 taggtaaggg ttgtttcgta tcaggagcaa ataaagagtt cattcgggag cagcgcatga
    14701 aaagattaga agagaaaatg ttagaaatca ttcaagacag cagggaatta agcatgagtc
    14761 aacaagattt aatcgagcat ctgactttat tgttcgagga ggaacagtca ccatgaatgc
    14821 aatagaatta cgtaatttaa cgaaaacata ccctgaattt acagtagatc aagtatcttt
    14881 ggatgtgaag cagggctaca ttaccggtct cattggtccg aatggcgttg gtaaaagcac
    14941 cttgatcaag atgatgatcg gcctgatccg tcctgactcc gggagtgtca aaatactagg
    15001 ctgcgatatg ccgaaccaag agattgacat taagcagcgc atcggtattg tatcggatga
    15061 ttgcttctat tatgagcatc ttacgattcg tgacacgaag agaatgattg cgcccttcta
    15121 taagaaatgg aacgaaaaga agttcaacag ctatcttgaa caattcgagt tgtctcccaa
    15181 gaagaagatc aaagacttat ccaaggggat gaaagtcaag ctatcccttg ctgttgcgtt
    15241 atcgcatgag gctgagctcc tcatcatgga tgagcctacc tctggacttg atcccgtgtt
    15301 tagaagggaa ttactcgacc tgcttgcgga tatgatgcag gatgagagaa attcgattat
    15361 tttctcgacc catattacaa cagatttaga tcggattgcc gactacattg ctttcatcaa
    15421 tcgtggcaag ctcgtattca atgaggcgaa agatgaagtg ctggacagat acgccattgt
    15481 aaaaggtgac tcacaactgc tcgattcaga tattcgaaac aaatttgtcg gaattcgcga
    15541 gactgctgtt ggttttgaag gcttagtaga taataggcag gaggtcgcgc agttgttcgg
    15601 aaattatgcg cttctagata agcccacctt agaagacatc atgtatttca ctgccaaggg
    15661 agggcgcatt catgcttaac ttgcttcgca aagacttcat cgcattgaaa agctcactgt
    15721 ggataagtat cctgtatctt gctgtattcg gtgctttttt tataccaaag ctttcttcgt
    15781 ctgtacacct tgtgggtatc tatacggctt tctccatgct tagtctcggt acgaacatcg
    15841 atattaaaaa ccataaccac aattttctga ttacgctgcc tgttaagcgc aagcatatta
    15901 ttcaagcaaa atacataacg gccatcattt acacactttt tggagttctt gcttcttatg
    15961 gcatccactc gctcgttaaa atagctgtcc cagagcttaa caagccaaac ttaacggtta
    16021 tggacatact aggaccagca gccatcgtgc ttgccctggc ttccatttat ttgccgctgt
    16081 tttatacgct tagcaagaaa ggaacctcta ttattaatgg tgtgttcttt atagccctaa
    16141 ttgctctggc gcagcctacg gctatgttta tgaatatgat ccacgtgaac ggcttacata
    16201 ctgacccaat cttatatttg attctgatcg gcatcttatt gctgttcatt gcttcctgct
    16261 tcttaactgc agctttgttt gcgagaaagg acttatagga ggccgcgcag ttgtatggcc
    16321 aaggtgatga ataataagga agggctggtc aaatgaaaaa taaaaaatgg atacttttgg
    16381 tgctcgccgg atggtcaaca ttagtcgtga gtctgttcct agctggtctt gccggtgaag
    16441 ctgctaacca gttgctcggc ctatcaggaa attctcgaac gttcgttcag ggtattgtaa
    16501 tgagcgggct ggttgttccg ataattttgt atttgtatcc gcatgtctat aagatcactg
    16561 gtgttaaatc caaaccatca gtatactcct ggaaaagact gcctcacttt atgactgggg
    16621 ttctcttggc aattgcactg gcttcattag ggttcataat agccagttct caagggtggg
    16681 ttgtcattga aaaatggcat acccccgatc agtggtttgc tgcgctgctt accaatgtta
    16741 tcgttgcttt tctatttgaa gctttaccag aggaattagg attgcgaggc atgctgtatg
    16801 atctcttacg tcatcgattc gcggcttggc ttgctgtttt atttcaaatt attctattta
    16861 tacttgtccc tatgacagct accgggcttc aagtgctctt tggacttgct cctggaaaca
    16921 ccattaacgt cttttatgtc acattaattc taagctttgg aacatgtttg cagctgctcc
    16981 gtctatggac cgggagtctc tgggcatcga ttgggtttca ccttgcctac ttagaaatca
    17041 tccggtttgt cttctcgccg catcaatatg gcggaccaat cataaccttc cacgaatcaa
    17101 tgcctggact tgtcggctcg atcacgataa gtatgattat tattgggggc atcattgtat
    17161 cactcgttat actcggtgcg aagcgtttta tacggaaaag tgaagggcga catacaactg
    17221 cttgattcag actgtcggtg gtgcgggctt agtagataat aggcagcagg cctcaccgtt
    17281 gaatggccac agcgagaaat aaaaaaggag agctaggtca aatgatagag acagagaaac
    17341 gcatcattta atctcatagg gaagtataaa aaggatggtc ttcgaagtcg tgaagagcat
    17401 ccttttctga ttaagtgtgt ttaggaagtt tcttcagaaa ttgttcgatt tcatccatat
    17461 aagccggtat cgtaatttgt ctgggagtga agagactaat gaagagtgcc cgcagattcg
    17521 aatgcgccgt ttgcttgctt aacatggaat gatcggcatc agggaagaca gctacggtca
    17581 gcagctcagg ttttacgata tcgcgatata cccgttccgt ctccttcaca tcgacctgca
    17641 agtcttcttc gcccagaatc aataacacag gtgtattgaa attacgaaga tcatcagtgg
    17701 catccgataa gaaatttttg ctgacaaatg tccatctgtc ttttgacatg aggctatttt
    17761 cgcgagctat ttttacatac tcttcatagg aagcttgttt ttccaaaagc ttgcgcactt
    17821 gccggtcata cgcctctttg tcttgaatct ccgcttcgga gtatccatcg tttttcattt
    17881 caatgcgtgt atagtattgt ccttgactta accaattaat tgcgggcgat agaaggaggc
    17941 taaatgcgag cggttccttc ttggccagct tgggaataac ccaacccgct tggcttgctc
    18001 cccaaacccc gattcgcttc tcgtcaatca tcggctgctg ttgtgcccat gcaatggcct
    18061 gacgggcttc ttccacacga tcatctatac tctgatgcag ccagttgcct tccgacccgt
    18121 taattcctct tttgttcagg gacaaagagg cgtaaccaag ggatgccaac cgcttgctca
    18181 actatttcaa tctcaggatc atatagtgcc atttcctttc attgaacaaa aaatgacgca
    18241 tgatactatt tccttgtgaa tgagtataga aggataactg ctcgtacaga tgcttggccc
    18301 gcggattttt acccgagacg tgcaggctta gcatattcag gcttggctct gcgtggacaa
    18361 gctgctgtgc ccattccaat agcatttttc caattccctt gcttcgatga tcgggatgga
    18421 cagcaacgtc agcaatataa cattccccag cttgcggttg atggtctaat aaagagagcc
    18481 caattaacaa tttaagaaag tcccacgttc caatgctgtg aaaactcctc cacgaaggaa
    18541 gctttctatt ttcttgcttt tttcctgaat ccgcattcca tttgatagac agagttccga
    18601 taacttgctc ctcttgcaga gcgacaatcc ttcgacttgc cgcttcagcg ggaaattgat
    18661 caaacagctt ctcgaaaaaa agagcaagct cttcatcgct caggctcgtc aggtgttgga
    18721 atttcccgcg aaacccgtga acgatcaatc ggctgacctg tggattgtac ttggcctgca
    18781 tcggttcaat cgttattcgt gaggcagtca tgatcattcc ctcctacgga tttgtcaccg
    18841 gttctatcaa gacttgcagt tcgtattgaa ccttgttgtt gataaagaga gataaataag
    18901 atttttcaat gaggactagg ggccctgata taacataaga ttgtgcagca gcatagtcgt
    18961 aaaactgttc aataacttgt tcaagctcat cctcttcctg aatggagcac tgcatcgaca
    19021 ggtaatctcc ctcaggcaaa gcaaaatcgc caggttcttg tacttccagg cacaacgcgt
    19081 tgatgtgtga accgtcatat atataatgaa tatccatttc gaacaagttc ggaatgcgct
    19141 tcgtgtgatc agctaatcgt gtggcagtaa gcttcgtgtg gaaatccatt tccatccagc
    19201 gcacaaaata ggtggtgtct cgccgcttga tttgatacgg gttggactgt gcagttacgt
    19261 tatgctgttc ctgcagcact ttggtaatga actgttgaag ctccatgaga cgctgcagct
    19321 ccatctctat ctctcgcagg gaagaatgaa gaagctgtcg aaattgatcc gcagtaaagg
    19381 aagtcatgca ttccttaatg gatggaacag ggactcccag cttgcgaagc aatagaatat
    19441 gcgccagctc gtatacttgc tcgatgccgt acattctata ctgattgtta tctgtgtagc
    19501 tgggctgaag aacgcctttc tcttcaaaat aacgaatttg gtgagcagac acgttcataa
    19561 gcttcgctaa ttcactaatt gtaatttcac ttttcatctc gttcactcct aaggataaag
    19621 cttggaatat ctcaacgata caccttaggt cagacctaag gtcaagtgtt tagataaaaa
    19681 tgaatttttg aatttacagt tgtaatagtt tcttgcatcg gttatattta catatgtaat
    19741 agttaagttg agatgagaag ggaggacaca caatggagaa aatgcccaag atttcggaat
    19801 ctgagtggga aatcatgaag gtcatttggc ggaaaaaccc gatgacagcc gagcaaattg
    19861 tgcagcattt gccggagggc acggactgga gcgatcagac ggtccgaacc tttatcaacc
    19921 ggctaatgaa gaaaaaagcg ctgggctacc agaaatcggg cagaagctat ctgtattatc
    19981 cgctaatttc ggaaaaagag tgcgtgcgcg cggaaagccg ttctttttta aaccgagtct
    20041 tcaatggcgc agccggatta atgatgacca attttttgga ggagacccag ctgtcagaac
    20101 aggagattga gcgattgcag caaattttgc tggagaagca aggaaaagaa tctaaagatt
    20161 caaaagactg atcacagcct tacaagcgtg aaatttaacc aaatgaggtt ataccatgga
    20221 tatagctgaa cgtctcttca attggtttgt tgcctcgacg ctgatggcaa gcgcagttgc
    20281 agtcgtggtg ctggcagttc agcatctgtt ccgcagacgc atccatgcgc gggtgaggca
    20341 tgcactatgg ctaattgtac tgttgaggct catgctgccg gtgctgcccc aaagtccggt
    20401 aagcttgttt aatgcagttc ctgcactgac agacataaaa aatgctgtct tcgggctgtc
    20461 gtaccagctg ggcaagcctg acacgatatc cgaacacagc caaatagaaa acacatatca
    20521 accttattat acaacgaatg aagctgagac gaatactgtt tttcatccgt ttgtgacctt
    20581 gaaggatacg gaagaacatg ccgaagcggg catagagaga gaaagccatc cggcttttcg
    20641 tgtgctggct gtagtgtggc tgacgggtgc ggccgtcttg ctcggatata acctgaccta
    20701 ctggctgcga ttccgaagaa aacaaaaaca tctcacacct gtcgacagtg ctgcgatatg
    20761 gaagattgcg gaacaatgcc gactcttatt ttccattaaa cgccctgtag ggatttacgc
    20821 ggatccatcc gctcagagtc cctatattac gggagttttc cgtccagccg tctatttgcc
    20881 gcaatcgctt atctcggaag cagtcaatga acaactgctt aagcacatca tcgcacatga
    20941 gctggcccac tacaaacgaa aggatacgat ctggaatatg atcggcagtc tggtgttcgc
    21001 tgttcactgg atgaatccat tcgtatggtt catgctgcgg cagatgaaag ccgaccggga
    21061 gctggcctgt gatgcctgtg ttctggaggc gcttggggaa gaggaggctg tgccttacgg
    21121 catgacgatt atcggatttc tgagacggta tgctgcggga agaggccagg cgcatcttct
    21181 ttatttcaaa ggttcgaacg atcaaaaaga gatgatgagg agaattagaa tgattcaatc
    21241 ttttaaaaag ggttcttata aattttcaat gatggcggtc attctcgtgc tcttgatcgg
    21301 tacggcaacg ctgaccaatg cgcgagcatc cgaagcggga gcttccgctt gggttcatgc
    21361 cgaagacggc gggaatgaaa tgctatttcc gagtgaagaa attcggtcat atgataatct
    21421 tgaaaaaggg gcgaaggagg cgccgtttac atttaaagtt ccctcctggc tgccagaggg
    21481 ctatggtttt agagggttga gcattacgtt taatgattcg ccaccacgtg tcggcctatc
    21541 gttcactgaa acgaaaagca aaagcagtgg caacttcggc ttgagtatct ggccaggcga
    21601 tgagctccag aaacaaaatg atctaatttt cagcatagag caagacgagg atagcgggaa
    21661 agtaatagag aaagaagccc tatccttagc cggcatagat gaaggctata aaattacgat
    21721 tcgcatgacc acgtggaagg gacagcctga aagatattat tatatctgga aggatcaagg
    21781 cctaagctat gaattaagct cccacatctt gtccagcaat gaaatggaga aaatcatcgc
    21841 ttccatgaaa tttcccgatg cagagctgaa caaacttcat gtagataatg attatcacga
    21901 taaaatcttg acctatttat atgatattga ggatatccgg cgtgctcagg agctggttgg
    21961 ttttaaagcc gcttttccgc gcaagctgcc cggggatttt gccgccagcg attcctatgt
    22021 ttcccgtaaa gcgaatttca atcacgtaga aaatgatgag gattccatgc gcaagatgtt
    22081 ttcggtcact tatagccgag gcgatcgcaa tcagaaaaat aaagctgact ccggtatcaa
    22141 agacgtctca tttaagcaaa tgttgaacgg ggatatgtat cagaagatga aaaagaacgg
    22201 ccgggtttct ttctcgataa ttagcggtga acggaatagt attaagctca aagccttaac
    22261 tcttcagggg caggaagtgc ttcgtacaga gccttataat cttgatggca cacctaaggg
    22321 ccctgatgat cttagtctag tcagctactt ctggtttgac ggccaggttt gctaccaagt
    22381 tgtattccaa ggcaagggag cgtaccaagg caagggagcg gaagaacaaa aaatagtgca
    22441 atatttaatg aaaccggacc ggtaaaataa gctgaaaaaa tggttgcagg ataaggaagc
    22501 gcccctaggt caatgaacct gttggggcgc ttttgcgtga agaagcttct ggggatagtg
    22561 gttactgctt tcgctacgtc cgaagagccg cgtactaatg aagcggtgaa atttacggct
    22621 gtcctttggt aataatattt tggagtgggt gaaccaacga ttttggagga ggaagaagaa
    22681 tgagtttaac tctatccttg gattttcagt tcacggcatc gatcgagaag gtatggtccg
    22741 ccttaactga ttcaagcaag cttgccaagt ggatcatgga aaatgatttt aagcccgacg
    22801 taggacaccg ttttcagttt cgcacgcagc cgaccgaatg gtggaatgga attattgagg
    22861 gcgaagtgct tatcgtggac gcaccacacc ggttgtccta tacttgggcc agcggagggg
    22921 agaagcacac cgtcacctgg acgctgcagg atgtagggga cggaaaggtt aaccttcatc
    22981 tcgaacaaac cggaatctca actgctcaag gactcgaagg tgctaaatat ggctggagtg
    23041 gatggtgcgg cgagcttgag aaagtgttgg aacaatagcc gcatccggta ctgcccatct
    23101 ccttccataa tgctaaatta gtgggtagga tagtgaaata gccaacatca gaaaacagat
    23161 cacttcgcgg tatctattcc gatcaagtga tctgttttta cacgtatgtc ggcagtattt
    23221 gacgcggcta attccttgac tagttgtcat aaattagtaa ttgacaagaa atcataacgt
    23281 ttggtaacgt gctataaaca acataaaatt ctctaaagga agatatatta tgacccaaga
    23341 atatatagaa atccgcggtg cccgggaaaa taaccttaaa gatgtatctt tgcgcattcc
    23401 caagcgcaaa atcaccattt ttaccggtgt atccggttcc ggcaaatcgt cgatcgtttt
    23461 cgatactatc gccgcggaat cgcagcgtct gctgaatgaa aacttcagta tgtttgtccg
    23521 cacctttttg ccgcgtattc cgcaaccaga tgcagacgcg atcgaaaatc ttagcatggc
    23581 ggtta
//
