LOCUS       NZ_VFNO01000003        23571 bp    DNA     linear   CON 16-AUG-2024
DEFINITION  Brevibacillus sp. AG162 Ga0222362_103, whole genome shotgun
            sequence.
ACCESSION   NZ_VFNO01000003
VERSION     NZ_VFNO01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Brevibacillus sp. AG162
  ORGANISM  Brevibacillus sp. AG162
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Brevibacillus.
REFERENCE   1  (bases 1 to 910716)
  AUTHORS   Venturi,V.
  TITLE     Genome sequencing of rice bacterial endophytes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 910716)
  AUTHORS   Venturi,V., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 236.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_006715575.1-RS_2024_08_16
            Annotation Date                   :: 08/16/2024 02:19:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,054
            CDSs (total)                      :: 5,923
            Genes (coding)                    :: 5,868
            CDSs (with protein)               :: 5,868
            Genes (RNA)                       :: 131
            rRNAs                             :: 1, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 6, 5 (16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 8
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 25 of 55
            Pseudo Genes (incomplete)         :: 38 of 55
            Pseudo Genes (internal stop)      :: 3 of 55
            Pseudo Genes (multiple problems)  :: 11 of 55
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:50:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 602014
            Orig. end                         :: 625585
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VFNO01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23571
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23571
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23571
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13571](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13571
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            167..946
                     /locus_tag="FB479_RS12845"
                     /old_locus_tag="FB479_103624"
     CDS             167..946
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015890990.1"
                     /locus_tag="FB479_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103624"
                     /product="TrmB family transcriptional regulator"
                     /protein_id="WP_106655122.1"
                     /transl_table=11
                     /translation="MIDELRKIGLSDLEARCYLVLHEEPKISGYEVAKKVSVSRTNVYA
                     ALRALTEKGMCRTIESEPVLYDAVPIEQLIRLLQSEFDQTTRVLQEQLKSTPRTSPSFY
                     NWQGDKAIETAIKRIISNANKSIVVDIWSEDVHWVEEPLIEAEKQGVAVTLISIGECHA
                     KLKNVVVHKRSAEWNQVQSRKFSILCDAHSALLGSFGRGIKPTVLETDHPSLIELLQNA
                     FYHDIIMGQIEKDFSPMLEEKYGSDYVRIITPYREYL"
     gene            complement(1157..1972)
                     /locus_tag="FB479_RS12850"
                     /old_locus_tag="FB479_103625"
     CDS             complement(1157..1972)
                     /NRPS_PKS="Domain: Abhydrolase_1 (33-136). E-value:
                     2.2e-21. Score: 68.5. Matches aSDomain:
                     nrpspksdomains_FB479_RS12850_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717930.1"
                     /locus_tag="FB479_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103625"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_142065458.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-17, bitscore: 59.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-18, bitscore:
                     63.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQPQENGMVTRKYFQSGNVKLSYLDFGGDSQRVLLLLHGHMNDA
                     RTFSEFASRFTDWRVIGLDQRGHGWSEHAPDTDYSREGYLNDILAFVQTVLDGAPVTIV
                     GHSLGGVNAYQFAAHYPELVNAVIVEDIGVEIKADLSFAEKLPHRSPSLHDLRKSLEEV
                     GVRAVDYFSESVFEDEQGWGFRSDLKGMPISQRHIDGEWWSDWLASSCPILLIHGQKSF
                     VLDENQADRMVTQRPNTKLASFAECGHDIHSTDPDGYYRAVRSFLDELK"
     aSDomain        complement(1565..1873)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FB479_RS12850_Abhydrolase_1.1"
                     /evalue="2.20E-21"
                     /label="FB479_RS12850_Abhydrolase_1.1"
                     /locus_tag="FB479_RS12850"
                     /protein_end="136"
                     /protein_start="33"
                     /score="68.5"
                     /tool="antismash"
                     /translation="VLLLLHGHMNDARTFSEFASRFTDWRVIGLDQRGHGWSEHAPDTD
                     YSREGYLNDILAFVQTVLDGAPVTIVGHSLGGVNAYQFAAHYPELVNAVIVEDIGVEI"
     CDS_motif       complement(1619..1675)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FB479_RS12850_0001"
                     /evalue="1.50E-05"
                     /label="NRPS-te1"
                     /locus_tag="FB479_RS12850"
                     /protein_end="118"
                     /protein_start="99"
                     /score="17.5"
                     /tool="antismash"
                     /translation="PVTIVGHSLGGVNAYQFAA"
     gene            2086..3036
                     /locus_tag="FB479_RS12855"
                     /old_locus_tag="FB479_103626"
     CDS             2086..3036
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016740491.1"
                     /locus_tag="FB479_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103626"
                     /product="YafY family protein"
                     /protein_id="WP_142065460.1"
                     /transl_table=11
                     /translation="MPKSKRLLEMMMTVNRKRKFTVSELAAEFGVSGRTILRDLQELSE
                     LGVPLYSEVGPHGGYHVLKERILPPIAFSEEEAVAIFFAIHALRHHTSLPFETESSSAL
                     NKFYQFMPPDIRDRIDQMKRRVDFVTPKRQASSPHLSTLLDAAIQQKVLSITYESRGQQ
                     STRDIQPIGIYTKNGLWYSPAYCFQQKHIRVFRCDRILSAEQSVSASKPLDLRDIHLEN
                     RQVKTVEDQDTVHLFAELTTEGVQACEAELWLASMLHVRQDGSGWLEGNVARSDILFFS
                     KFLIGLGKEVTVQHSPEILNGIKTYLAELINIYSQ"
     gene            3047..3382
                     /locus_tag="FB479_RS12860"
                     /old_locus_tag="FB479_103627"
     CDS             3047..3382
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717936.1"
                     /locus_tag="FB479_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103627"
                     /product="hypothetical protein"
                     /protein_id="WP_142065462.1"
                     /transl_table=11
                     /translation="MALPKKGTRGITVGEQRYRWVISPAAKGLLALTIQHNEGMGQLIR
                     VYVKSDVNDFWAEFPLVQHLDMRVIKPADVAAIIEEALKLGWQPDKKGAPLSFYFIGST
                     LVKKGDT"
     gene            3433..4143
                     /locus_tag="FB479_RS12865"
                     /old_locus_tag="FB479_103628"
     CDS             3433..4143
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225032.1"
                     /locus_tag="FB479_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103628"
                     /product="DUF4274 domain-containing protein"
                     /protein_id="WP_142065466.1"
                     /transl_table=11
                     /translation="MDWATVSKTKDLEIVRAAVDQLDINERDQRGRTPLMLFITNRMPV
                     EAIQMLLDKGTELEAEDKLGDTALKKAVKFKQVEAVKRLLQQGAELDSKHGILATAWNA
                     ARMDKAIADLLLETKGAVRLTLSTEEEEAVDDILYEESEGKRRKKISQLDLSVLLHAVV
                     NGYNWDDGPEAMIAAFENPACATITLLDMYELMDADYWLEMDEEETTESEERKRWRMLA
                     IQLKEKLADEWDRG"
     gene            4149..4523
                     /locus_tag="FB479_RS12870"
                     /old_locus_tag="FB479_103629"
     CDS             4149..4523
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717939.1"
                     /locus_tag="FB479_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103629"
                     /product="hypothetical protein"
                     /protein_id="WP_142065468.1"
                     /transl_table=11
                     /translation="MCRYGMYGPYKQIYACFPCRKVFKQTSKYELTEEEWNKIEHSCPQ
                     CGEGMKDMGHDFKAPKQTDVKQWKKVEILYQHGFTYHSCGCGGPGYRPAQLNEVNEFLE
                     KNKRFKTEGEKLLNRLTVSM"
     gene            4546..5742
                     /locus_tag="FB479_RS12875"
                     /old_locus_tag="FB479_103630"
     CDS             4546..5742
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717942.1"
                     /locus_tag="FB479_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103630"
                     /product="sugar MFS transporter"
                     /protein_id="WP_142065470.1"
                     /transl_table=11
                     /translation="MATFFLIMIYLSFISLGLPDSLLGAAWPVMQAEYGAAFGVAGVIT
                     IVISSGTIVSSLASGALLKRLGTGQITLISCLMTAAALLGFYFSPSIIWLMVLALPLGL
                     GAGSVDAALNHYVATHYQAHHMSWLHCFWGVGATLGPIIMSGFIRDHGLWRNGYLTVSL
                     IQFGLVILLAFTLPLWKRMENMQSHAVKESQGQPFGGQSEQPLRTKGVKLTLLSFLFYC
                     GAEASVGLWGSSFLVNVKELPVAVAAVWVAMYYGGITVGRFITGFVTFKVSNRVLIRSG
                     LLVSFAGAALLMLPLPTYYSQIGLLLLGLGFAPIYPCMLHDTPERFGKEQTQKLMGYQM
                     AVAYTGATLLPPLLGWLATQTTVSILPFFTAFYIVFILYGSERVNRIMKQRAAQSETI"
     gene            complement(5756..6355)
                     /locus_tag="FB479_RS12880"
                     /old_locus_tag="FB479_103631"
     CDS             complement(5756..6355)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017248321.1"
                     /locus_tag="FB479_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103631"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_106655129.1"
                     /transl_table=11
                     /translation="MNRRRLTQAERKQETRQLLIDAAIETFAQLGFHGASVDKIADHAG
                     FTKGAVYAHFQSKEDLFLAILEGQMQLHVSNIHHVIDHQPSLSHFIEAMDAYFMSVQQQ
                     NRTWNMLNLEFLLYAMREESVRKRWSNMIIESVQHLSKAIQTLMPKESDSTLSADEMAW
                     TILALENGMTIFYYMSGDQVPLSLYGKALQNMLSSK"
     gene            6536..7453
                     /gene="cyoE"
                     /locus_tag="FB479_RS12885"
                     /old_locus_tag="FB479_103632"
     CDS             6536..7453
                     /EC_number="2.5.1.141"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008495 - protoheme IX farnesyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006783 - heme biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyoE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017248322.1"
                     /locus_tag="FB479_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103632"
                     /product="heme o synthase"
                     /protein_id="WP_142065472.1"
                     /transl_table=11
                     /translation="MQREESVATRNRPMSNILAQTVKTGIIKSNLIPMFAGLTLALYTY
                     HFSLIDKLPEILFATIGSILIMGAAGAFNNVYDRDIDSVMERTKNRPTVTGEISTKTVL
                     WLASLMTIFGLVALVLATPLAAIMGFLGLFFYVVPYTMWTKRRTVYNTEVGSISGAMPP
                     LIGWAAIHPDITHPAILGLFIIMVIWQMPHFYAIAIRKHDEYKAAGVPMLPVVKGARRT
                     YIQTNVYLVILIASSFLFWSLSAGLTFMALLLNILWLVLSVFGYRKMDSQKWSKTMFIY
                     SLIHMTVLFSTVIIYSLMGIIFKL"
     gene            7633..7893
                     /locus_tag="FB479_RS31270"
     CDS             7633..7893
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03601.1"
                     /locus_tag="FB479_RS31270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="heterocycloanthracin/sonorensin family
                     bacteriocin"
                     /protein_id="WP_106655131.1"
                     /transl_table=11
                     /translation="MDDFKKELKKLKASEIKADKVQPWDKQKMNEATLVRGRCGCGRCG
                     CGRCGCGRCGRCSCSCSCFCSCSCSCFCTCSCTCFFPCFIV"
     misc_feature    complement(8033..8046)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.54"
                     /tool="antismash"
     aSDomain        8061..8357
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FB479_RS12895_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="6.40E-43"
                     /identifier="RREFam011.1"
                     /label="FB479_RS12895"
                     /locus_tag="FB479_RS12895"
                     /protein_end="99"
                     /protein_start="0"
                     /score="135.6"
                     /tool="antismash"
                     /translation="MVKLNPSMRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGDMIERW
                     VDQLMPMFNGEYTLAQLTDDLPEEYQQQIYQVAGTLLQNGFLQDISREKPHELS"
     gene            8061..10004
                     /locus_tag="FB479_RS12895"
                     /old_locus_tag="FB479_103634"
     CDS             8061..10004
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016740498.1"
                     /locus_tag="FB479_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103634"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_142065474.1"
                     /sec_met_domain="TIGR03693 (E-value: 1.7e-180, bitscore:
                     596.9, seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     1.9e-41, bitscore: 135.6, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.5e-12,
                     bitscore: 43.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNPSMRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGDMIERW
                     VDQLMPMFNGEYTLAQLTDDLPEEYQQQIYQVAGTLLQNGFLQDISREKPHELSPEIIS
                     AYAEQIEFLDQFGGSGGYLFQKYRTEKVLIVGAGSFLLSIAHALLESGCVQFHYVITNE
                     APTKRERLDAIIEHARRKDPHVKLEELKPASWGIAEWSEAIEPFSAVLYTSAQVNKDEI
                     SVIHSACRERKKVFVPAVCLMQKGIAGPLIHPESEACLESAWRRLHRQTLCADPDQHPF
                     SMTAAAMLANVAVFEWFKHVTGVNDNEDENKVYVLNLETLEGSWRSFLPHPMVKEGMRL
                     EVLDRKELESRLSNETEPKEGLQSLFQSWTSSDTGIFHSWDEGELTQLPLTQCNVTAVD
                     PVSEGPAELMPQIVCPGYTHEEARREAGLLGAEMYVGRMVNHLAAIDSAFRNVGNGNIG
                     VGAGETAAEGLNRALRHCLTLTYAADMKGRQPTARPVHTDTIADERCQFYIRSFTTLGE
                     KPTIAKGHEVFGFSVYWVETSTGWYGSIGLQEREALRSALMYALQQIQTPTNQMSKYVL
                     TAQSVGLTGEAIEVARNSVQKESEKEVWKQAVEVLALHHLSPRVMNAAMEPFLEEDLGG
                     VFALLLSREVPR"
     aSDomain        8082..8324
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FB479_RS12895_Thiopeptide_F_RRE.1"
                     /evalue="5.10E-14"
                     /identifier="RREFam004.1"
                     /label="FB479_RS12895"
                     /locus_tag="FB479_RS12895"
                     /protein_end="88"
                     /protein_start="7"
                     /score="43.0"
                     /tool="antismash"
                     /translation="MRIKVKRDTVYLPDSDGSVYFRNNIGTFRMKGDMIERWVDQLMPM
                     FNGEYTLAQLTDDLPEEYQQQIYQVAGTLLQNGFLQ"
     gene            10001..11941
                     /locus_tag="FB479_RS12900"
                     /old_locus_tag="FB479_103635"
     CDS             10001..11941
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016740499.1"
                     /locus_tag="FB479_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103635"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_142065476.1"
                     /sec_met_domain="TIGR03882 (E-value: 1.9e-47, bitscore:
                     157.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 3.7e-76, bitscore: 252.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 8.5e-124, bitscore:
                     408.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADILVIGDGVLAELVSERLRKDYRVWHSENMESATSGADLALL
                     LQDTYHPALHLQAEKHFRQTNIPWLRGFVSFGEAIVGPLVLPGQTGCSQCADIRRLMAG
                     RDRKEMWKVQHMFSEKGGIPRDPWSSRSGLLQVAFHVSAEVERIVEGRQAQLSEHIQFI
                     DLQTLTSTRHFFLPNPLCPVCSRLPEDSEEQARVRLKPIVKQSPDSYRTKPIADLKQAL
                     PTEFLDSRTGFLNGKVRDLVSVFADVSVNLPLFSHDEGTAGRSVSYADSEITAILEGME
                     RYCGLMPRGKRTMVRDCYANLAPHALDPTTAGTHSEEQYALPDFPFQPFDPKQDMNWVW
                     GYSFKEERPILVPELMAYYSMGFGEGVVFETSNGCALGGSLEEAIFYGILEVVERDAFL
                     MTWYAKLPLPRLDPASVNDRELLLLIDRMQTVTNYDLYLFDATMENGIPAVWTIAKNRG
                     EAGLHLVCAAGAHPDPIRAVKSSIFETAAMLMPLTDKYEANRDKYLRMLHDSSLVKKMD
                     DHAMLYSLPEAAERLSFLMDDSRPMVSFAEQFPKRKQHRDLTDDLRELLGVFQKLDLNV
                     IVVDQTTPEVERHGLSCVRVLIPGMLPMTFGHHLTRVTGLKRALEVPVKLGYAKQPLRV
                     EELNPFPHPFP"
     gene            11964..13571
                     /locus_tag="FB479_RS12905"
                     /old_locus_tag="FB479_103636"
     CDS             11964..13571
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017248326.1"
                     /locus_tag="FB479_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103636"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_142065478.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-06, bitscore: 24.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLENFLYRLHFDTENARPSDLEVDWEDAPLTYKLYRGLPVIPLP
                     EDVPLSLIDQTVSQEMSLPQLGAWLWYSYGLIQISQSLLTTIPGDAGSESFLPLVTNRR
                     PVPSGGGLYPSELYVYLKLSSIPAGLYHYDVAHHRLVRLREGNFDDVLSRALGGHCPVH
                     ACFGVAFVSIYFWKNFFKYDEFSYRLQGLDAGVLLGQLQEMANQLGVTNAVHYQFLDRA
                     MNALLGLSVDQESVYAVVPLSLQTEGERHSHSPAHWAERGEETASELIRELPEQKHVHV
                     MRSKRMRQYPVLLRMNEAAMQESPHSFTSYSDHLENKWTRRSEERILLPRLEKPSYDLA
                     QFSRERFSPEMDFIRRKTGRDQVARIMEMAMSVLSYGNDLGKNQEVAWRRLSLLVSIHQ
                     VEGIQDGAYAYEPLEHALYPIVYGDLRARLQDGMTLDNVNLYQVPLCFHVAGKRDHLIN
                     QLGFRGYRIQQMEAGIVVHRLLLAAFTCGMGGHPLLGFDVKNCDDLYNLETEEKTCLIQ
                     IPVGHYRPRARFQGGLHG"
     gene            complement(13613..15358)
                     /locus_tag="FB479_RS12910"
                     /old_locus_tag="FB479_103637"
     CDS             complement(13613..15358)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (197-571). E-value: 2.7e-66.
                     Score: 215.9. Matches aSDomain:
                     nrpspksdomains_FB479_RS12910_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01976.1"
                     /locus_tag="FB479_RS12910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103637"
                     /product="cysteine desulfurase-like protein"
                     /protein_id="WP_142065480.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.7e-64, bitscore:
                     212.3, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.2e-08,
                     bitscore: 29.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTLNTELVRIQPWADHDLPLLHLLNAPAMMEHVGGPETEEQLL
                     ARHERYVNKDGQQSSKMFSIVLLPDHIPVGSIGYWDRIWQGEHVYEVGWSVLPPFQGKG
                     IASAALASLITRINQERRHKFIHAYPSVDNPASNAICRKLGFTLQSECVFEYPPGSFMR
                     SNDWRLEVASEHYPIEKVREQFPALQRTYEGKPVVYLDGPGGSQVVKSSMDAIYRFMAN
                     GGANLHGSFPTSKETEAILADAKQAVADLFHVRPKEVAFGANMTTLTFAIARALGRHWK
                     EGDEIIVSEMDHRANVDPWLTVAADRGMTVRWLKVNKETLTLQLDELDTLLTSRTRLVA
                     VGLASNAVGTIHDLAAISQKARAKGVIFAVDAVHAVPHFSIHRDEIGADILLCSAYKFF
                     GPHVGIAVIRKEIFEALDVYKLVPAPSSYPDKLETGTQNHEGIAGIRPAIEFVASLGFG
                     DSFAEKIRSGYEMIEAYENHLADKLRKELSAMKGVTLYQAGEDVPKTPTVAFRIEGFSP
                     REICERLCEEHSIFVADGDFYATTLANCLGINESGGWIRAGLAPYNTHEEIDRFIQGIK
                     AIIRT"
     aSDomain        complement(13646..14767)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FB479_RS12910_Aminotran_5.1"
                     /evalue="2.70E-66"
                     /label="FB479_RS12910_Aminotran_5.1"
                     /locus_tag="FB479_RS12910"
                     /protein_end="571"
                     /protein_start="197"
                     /score="215.9"
                     /tool="antismash"
                     /translation="VYLDGPGGSQVVKSSMDAIYRFMANGGANLHGSFPTSKETEAILA
                     DAKQAVADLFHVRPKEVAFGANMTTLTFAIARALGRHWKEGDEIIVSEMDHRANVDPWL
                     TVAADRGMTVRWLKVNKETLTLQLDELDTLLTSRTRLVAVGLASNAVGTIHDLAAISQK
                     ARAKGVIFAVDAVHAVPHFSIHRDEIGADILLCSAYKFFGPHVGIAVIRKEIFEALDVY
                     KLVPAPSSYPDKLETGTQNHEGIAGIRPAIEFVASLGFGDSFAEKIRSGYEMIEAYENH
                     LADKLRKELSAMKGVTLYQAGEDVPKTPTVAFRIEGFSPREICERLCEEHSIFVADGDF
                     YATTLANCLGINESGGWIRAGLAPYNTHEEIDRF"
     gene            15534..16046
                     /locus_tag="FB479_RS12915"
                     /old_locus_tag="FB479_103638"
     CDS             15534..16046
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015891003.1"
                     /locus_tag="FB479_RS12915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103638"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_106655136.1"
                     /transl_table=11
                     /translation="MNEKSIHTQRLILIPFTHRIATNILQENYEELLDMGLTLGKGWPD
                     EDAMETIPKIIKALELAGEPTGFESWMIITKDGRKIIGDAGFKGAPNTEGEVDIGYGII
                     EAERKKGYAYEAAEGLANWALLQPDVKKITAKCLLDNIDSAKLLVKMGFTEIKRDDTMI
                     YWSSQKG"
     gene            16199..16810
                     /locus_tag="FB479_RS12920"
                     /old_locus_tag="FB479_103639"
     CDS             16199..16810
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717970.1"
                     /locus_tag="FB479_RS12920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103639"
                     /product="DedA family protein"
                     /protein_id="WP_106655137.1"
                     /transl_table=11
                     /translation="MQNWMTQIIEQYSYFGILLMMALENIFPPIPSEVILTFGGFMTTQ
                     SSLTVFGVILSATIGSVIGAIMLYGIGFYLDVQKIEKIVERWGHLLRIKTADIHKANEW
                     FDRYGYWTIFFCRMIPLIRSLISIPAGMTKMNFPLFLLFTTLGTFIWNIVLVMAGHLLG
                     ESWEDILYYFDLYSNVVYVVLAFTGVAFLIFFLRKRKADA"
     misc_feature    16887..16903
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 26.36"
                     /tool="antismash"
     gene            16994..18478
                     /locus_tag="FB479_RS12925"
                     /old_locus_tag="FB479_103640"
     CDS             16994..18478
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017248331.1"
                     /locus_tag="FB479_RS12925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103640"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_185746361.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.8e-33, bitscore:
                     111.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDLLLVDGVVITMDKDRRVLQDGAVAIDKGRILEVGDTPLLKDK
                     YPAQKVVDCAHHCILPGFVDAHGHGGHSLFKTIATDNINDWMPIMTNTYKHYVTDDFWY
                     YEGKLSALERLKAGITTGVSVLGSMPRSDDPIFALNHAKAYNEVGVREIVATGPCNPPW
                     PHPFSRWVDGQKVTKEVTYEQVLAGAEAVIEALNHANNDKTRAYITPFVIVTSVNPSYP
                     TPADQLFGLTDFDRYQARKIREIAKKYDTRIHSDAFGGMIHLAIQDKEYALLGPDVHLQ
                     HCRGISFDEAKILAETGTNVSASPGFGQINARTPITELLEMGATVAITTDGTSPMTPFD
                     MFQAMRRMQLLQQAALRDYYYLPPGKLLEMVTIDAARCVGWDDELGSLEAGKKADVITV
                     NMHQAHLNPENMHVHRVVYQAVGGDVNHVIVDGELIMDERRVLTVDEKQILKEANEEAN
                     RTIERAGLEIYMQPSKYFWGHARAYLDERRFDPTKL"
     misc_feature    complement(18559..18568)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            18665..19507
                     /locus_tag="FB479_RS12930"
                     /old_locus_tag="FB479_103641"
     CDS             18665..19507
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717977.1"
                     /locus_tag="FB479_RS12930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103641"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_142065482.1"
                     /transl_table=11
                     /translation="MYLTIDNVTKHFENEQKQKVKVLDDINLEVEKGSFVSIVGPSGCG
                     KSTLLYLIAGLDRPDSGDIHVAGNKVNKPGPDRVVVFQEAGLFPWLTVLENVTYGLKLK
                     KMSAAKANEKALEVLKMVHLSKYVHSYPHQLSGGMKQRVAIARALVMEPDILLMDEPFS
                     ALDEQTRMVLHKELLEIWRTTKVTIFFVTHNIREAVQLGEKIVVFATRPGKIKEIIAVP
                     AMRDGVMPDSVTLSTEQKVLSILQEEIEKVLKEEMGNDYSFKTGHLHRYDSGDLGSHI"
     gene            19440..20195
                     /locus_tag="FB479_RS12935"
                     /old_locus_tag="FB479_103642"
     CDS             19440..20195
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020372021.1"
                     /locus_tag="FB479_RS12935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103642"
                     /product="ABC transporter permease"
                     /protein_id="WP_020477521.1"
                     /transl_table=11
                     /translation="MTTALRRVIFIAMIAAIWEVTSRLSGLPSFMFPSLTQVFETLVNG
                     LISGQITAAIGKSMGRILLGFLIAIIVGLILGYFIWRYKLVEDTLGFVVTALQSIPSIV
                     WFPLAIIWFGLNDFSILFIVTIGATWTMTVNATSGFKNVPPLYQRVAKTYGSSGFHFVR
                     TVILPASVPQIISGLRIAWAFSWRALMAGELLGGGGGLGQLLEMGRSLGQMDLVISVMI
                     IIAIIGTIVDNVVFSRIERNVQMKWGVHS"
     gene            20227..21222
                     /locus_tag="FB479_RS12940"
                     /old_locus_tag="FB479_103643"
     CDS             20227..21222
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0042918 - alkanesulfonate transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007717982.1"
                     /locus_tag="FB479_RS12940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103643"
                     /product="aliphatic sulfonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_142065484.1"
                     /transl_table=11
                     /translation="MLKKVLSTVVASLLLMGVASGCSTGGAESSEKEVRIGYFPNLTHS
                     ATIIALEKGYFKEAFGADVKIQTKTVTNGGLFMEAMATKAIDVGTVGPGPLLNFYVKHP
                     GYRLISGAVNGGAVLVMNGSTNITELKDLKGKKIAIPVIGSTQDVMLRKALNEVGLKPT
                     TNGGDVELYAAAPADTAALFVQKSVDGAATQEPWGYVLENQAEGKLLLDWDQFAWGKES
                     TNTVVAASDEFLKREGLATAYLQAHKKAVKFIQENPEESQDLIIKHLKGLTGKELSKKE
                     VQAAFSRLEVTTAVNEKVIQEMADISQEAGYISSNKIDGLIDLKYLEAVK"
     gene            21302..22162
                     /gene="kynA"
                     /locus_tag="FB479_RS12945"
                     /old_locus_tag="FB479_103644"
     CDS             21302..22162
                     /EC_number="1.13.11.11"
                     /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /gene="kynA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015891010.1"
                     /locus_tag="FB479_RS12945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103644"
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="WP_142065486.1"
                     /transl_table=11
                     /translation="MRPHEQGSNQPNDTSLETQIHTDFQKEMTYGDYLQLDQILSSQQC
                     QSSHHDEMLFIIIHQVSELWMKQILHELSAANECICNHDLEPAFKMFARVSRIQQQLIK
                     SWDVLSTLTPADYLQFRDKLGHSSGFQSYQNRLIEFTLGYKNQHVLAVYAHQPELHAQM
                     SAALQQPSIYDAAIREMAARGLPIDPECLNRDWSQPYQPNQSVEQAWLTVYRNVNQYWD
                     LYELAEKLVDIASQQQQWRFNHMTTVERIIGQKPGTGGSSGVMYLRRALDHRFFPELWS
                     LRTLL"
     misc_feature    complement(22291..22304)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    22291..22304
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.31"
                     /tool="antismash"
     gene            22362..23462
                     /locus_tag="FB479_RS12950"
                     /old_locus_tag="FB479_103645"
     CDS             22362..23462
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018766749.1"
                     /locus_tag="FB479_RS12950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FB479_103645"
                     /product="AAA family ATPase"
                     /protein_id="WP_185746362.1"
                     /transl_table=11
                     /translation="METMKPPMEVLYAKQLNALRSHDTGTKPPNWLMSPRAVRDFILGT
                     DEPLSYEGESITITKKFYGDDVLIERAIVTLAGNRGLMLVGEPGTAKTMLSELLSAAIS
                     GTSTNTIQGTAGTTEDMIKYSWNYAMLLDKGPSLQALVPSPLYTGMSKGIITRFEEITR
                     CPFEVQDVLISILSDKVMNIPELSDGILFAKPGFNIIATANLRDKGVNEMSSALKRRFN
                     FETIAPINHVKMEAQIIESQAKVILEQSGVNIEIDRDVVEILATTFMELRMGETKEGFK
                     IDSPQSVMSTAEAVSVYVQSAMTSHYYDGRPISMDRLVQNMLGAVVKENQKDANILKTY
                     FTKVVKERAKEEGLWGTYYNEKKWIK"
ORIGIN
        1 atcctatgtg agtatgttac gagttttcaa tggggagata gtcttgtgga gggaatattt
       61 caatccgatt gagttgcaga aggtgctgga ttcataggac tgttgacttt ctcacgggac
      121 aatagcagta ttcatatata ctactaaaca aaaaggaggt aacaacttga ttgatgagct
      181 ccgaaaaatc ggattgtcag acctagaagc cagatgttat ttggtgcttc acgaggaacc
      241 caaaatatct ggatatgaag tggccaagaa agtttccgtc tctcggacaa acgtatatgc
      301 tgcacttcga gcattaacgg aaaagggcat gtgccgcaca atcgaatcgg agcctgttct
      361 ttatgatgca gtaccgatcg agcagctgat tcgtttgtta caatcggaat ttgatcaaac
      421 aacccgtgtc cttcaagagc agttgaaatc cactccccga acgtctcctt ccttttataa
      481 ttggcaaggt gacaaagcga ttgaaacagc catcaaacgt atcatctcaa atgcaaacaa
      541 aagcatagtt gtcgatattt ggtctgaaga tgttcattgg gtagaggagc cactgataga
      601 agcggaaaaa caaggggttg ctgtcacgct aatatccatt ggcgaatgcc atgcaaagct
      661 aaaaaatgtt gtcgtacata aaagaagcgc ggaatggaat caagtgcaat ccaggaagtt
      721 ctctatactt tgcgatgcac attcagcgtt gctgggcagc tttgggcgtg ggatcaagcc
      781 aactgtactg gagacggacc acccatctct cattgaattg ctgcaaaatg cgttctacca
      841 tgacataatc atgggtcaga tcgagaagga tttcagcccc atgctggaag agaaatatgg
      901 gagtgactat gtacgcatta tcacacctta cagggaatac ttataacgag tatttcctct
      961 ttttatcaac aaaacagtgg cttcaagtac gaagaagact ctcgtaatca accaaaagag
     1021 aattgaacac gtaaagctaa taatattcat ttacagccaa tccttagagg gttggctgtt
     1081 tgttatggag gagccttaaa aagggaggta gagactttcc gatgtctctt cccccctttt
     1141 atgcgtgcat cgtctattat ttcaactcgt cgagaaagct tcttacagcc cgatagtatc
     1201 cgtcagggtc cgtagaatgg atatcatgcc cgcactcagc aaaacttgca agctttgtgt
     1261 ttggtctttg cgtcaccatg cgatcggctt gattttcatc caatacaaag cttttttggc
     1321 catgaatcag caagatcggg caagaagacg ctagccaatc gctccaccat tctccgtcaa
     1381 tgtgtcgttg agaaataggc atgcctttta aatcagaacg gaatccccag ccttgttcat
     1441 cctcaaacac gctttccgaa aaataatcga ccgcccgaac gccgacttct tcgagtgatt
     1501 ttcttagatc gtgtaaagaa ggggagcgat gtgggagttt ttctgcaaag gataagtcgg
     1561 ccttaatttc tactccgata tcttccacaa tgaccgcgtt cacaagctcc ggataatgag
     1621 cagcaaattg ataagcgttg acacctccta aagaatgccc aacgatcgta acaggagctc
     1681 cgtccaaaac ggtctgaaca aaggcgagaa tgtcgttgag gtagccttca cgtgaataat
     1741 ccgtatctgg ggcatgctca ctccagccgt gaccgcgttg atccaatcca atcacgcgcc
     1801 aatctgtgaa tctggaagca aactctgaaa atgttcgtgc atcattcata tgaccatgca
     1861 gcaggagcaa aactctttga ctgtccccgc caaaatcgag gtaagatagt tttacgttac
     1921 ctgattggaa atattttctc gttaccatac cgttttcttg tggctgaagc atacacaatt
     1981 cctccttatt tatcatcagc atcatgtcca actcgacttc tccttcacca taacagataa
     2041 tagtgacagg aattgtcata ataaaaacat gtggagagtt atgtcatgcc gaaatcaaaa
     2101 cgactgctgg aaatgatgat gactgtcaac cggaagcgca agtttactgt gagtgagctt
     2161 gctgccgaat ttggcgtatc agggcgaacg attctaaggg acttacaaga gctgagtgag
     2221 ttaggggtac ctttgtactc ggaggtggga ccgcatggtg gatatcatgt tttgaaggaa
     2281 aggattttgc cgccgattgc attctcagag gaggaggcgg tcgcaatctt tttcgcgatc
     2341 catgctcttc gacaccatac ctctctgccg tttgagacag aatcctcttc ggcgctgaac
     2401 aaattttatc aatttatgcc gccggacatt cgtgatcgca ttgatcaaat gaaacgccgc
     2461 gttgatttcg tgacaccgaa gcggcaagcc agctctccgc atttatccac tctgctggat
     2521 gccgccatcc aacaaaaagt gctcagcatc acttatgaat cgcgcggaca acaatccaca
     2581 cgggacatac agccgattgg aatttataca aaaaacggtc tatggtacag cccggcttat
     2641 tgttttcaac agaaacatat tcgcgtgttt cgttgtgacc gtatcctctc tgccgaacaa
     2701 tcggtatcgg catcgaagcc gttggatctt cgagacattc acttggaaaa tagacaggtc
     2761 aaaaccgtcg aggatcagga caccgtccac ttatttgcag agctgaccac tgagggtgtg
     2821 caggcttgtg aggctgaact ttggcttgca tccatgctgc atgtgcggca ggatgggagt
     2881 ggttggttgg aaggaaatgt agcgagaagt gacatcttgt ttttttcaaa gtttttgatt
     2941 gggttgggga aagaagtgac ggtccagcat tcacccgaaa tattgaatgg aataaaaacg
     3001 tatttggcag aactgataaa catttactct caatgaggag gcagctatgg cattacccaa
     3061 aaaaggcaca cggggtataa cggtaggaga gcagcgatat cgttgggtca ttagcccagc
     3121 agcgaagggt ctgcttgctt tgacgattca gcacaatgaa ggaatggggc aactgattcg
     3181 cgtgtatgtc aaatcagatg tgaatgattt ttgggcggag tttccacttg tgcagcattt
     3241 ggatatgaga gtgataaagc cagctgacgt tgcggctatc attgaagagg cgctcaagct
     3301 ggggtggcag cctgacaaaa agggggcgcc tttgagcttt tacttcatcg gtagtacgct
     3361 tgtcaaaaaa ggggatacat agcaataccg gaacgggagt tgtctataga gaagaagagg
     3421 agaggaagcc ggatggattg ggcaaccgtc agcaagacaa aggatcttga gatcgtgcga
     3481 gcagcggtgg atcaattgga tatcaacgaa cgagatcaac gcggacgaac accgctgatg
     3541 ctttttatca caaaccgaat gccggtggaa gcgattcaga tgctattgga taaaggcaca
     3601 gagctggagg cggaagacaa acttggtgat acagcattga aaaaagccgt caaattcaag
     3661 caagtcgaag ccgtaaaacg attgctgcaa cagggagctg agcttgattc taagcatggc
     3721 attttggcga ctgcttggaa tgcggccagg atggataaag ctatagcaga cctgctgctc
     3781 gaaacgaaag gcgccgtacg tctaacactg tctactgagg aagaggaagc ggtggacgac
     3841 attttatatg aggaatctga gggcaagcgg cgcaagaaaa tcagtcagct tgatttatct
     3901 gttcttcttc acgctgtggt gaatggctac aactgggatg acggacctga ggcgatgatt
     3961 gcggcttttg agaatcctgc ctgtgcaacg atcactcttt tggatatgta tgagttgatg
     4021 gatgccgact attggttgga gatggacgag gaagaaacta cggaatcgga ggagcgaaaa
     4081 cgttggagaa tgctcgccat ccaattgaaa gagaagctgg cagatgaatg ggataggggt
     4141 tgatcatcat gtgtcgatat gggatgtatg gtccgtacaa acaaatatac gcctgtttcc
     4201 cttgccgaaa agttttcaag caaacctcca agtatgagct gacggaggaa gagtggaaca
     4261 agatcgagca tagctgtccg caatgtggtg agggaatgaa ggatatgggg catgatttca
     4321 aggctccgaa gcaaacggat gtgaagcagt ggaaaaaggt tgaaatcctc tatcagcatg
     4381 ggtttaccta tcattcctgt ggctgtggtg gtccaggcta ccgaccagcc caattaaatg
     4441 aagtgaacga atttctcgaa aagaacaagc ggttcaaaac agagggagag aaattgctga
     4501 atagactcac agtaagtatg taaaaacgac cagggggcgg ggatcgtggc aacattcttt
     4561 ttgatcatga tttacttgtc gtttatcagc ttgggccttc ctgattcgtt actgggggca
     4621 gcttggccgg tcatgcaagc agaatatggt gcggcattcg gtgtagcggg tgtgatcacc
     4681 attgtgattt catctggtac gatcgtgtca agcttggcaa gcggagcttt attaaaacgg
     4741 ctcggtactg gacagattac gctgattagt tgcttgatga cagcggcagc cttgctcggc
     4801 ttttattttt ccccttccat tatatggttg atggtattgg cattgccgct tggactcggt
     4861 gctgggtctg ttgatgctgc actgaatcat tatgtcgcca cgcattacca agcacatcat
     4921 atgagctggc tgcattgctt ctggggtgtg ggtgctacgc ttggccccat tattatgtct
     4981 ggttttattc gtgatcatgg tttatggcgg aatggatact tgaccgtttc gcttatacaa
     5041 tttgggttag tcattctgct agcgtttaca cttcctttgt ggaaacggat ggagaacatg
     5101 cagagccatg ctgtcaaaga gtcacagggt cagccgtttg gtgggcagag cgaacaaccg
     5161 ttacggacaa aaggcgtcaa gctgactttg ctgagctttc tcttctattg tggggctgaa
     5221 gcatcggtgg gattatgggg gagcagcttt ttggtaaatg tgaaagagct acccgtggct
     5281 gtggcggcgg tgtgggtagc catgtattat ggtggcatta ctgttgggcg atttatcacg
     5341 ggctttgtta ccttcaaagt gagcaaccgc gtcctgattc gcagtggact tcttgtatca
     5401 ttcgctgggg cagcgctgtt gatgttgcca ttaccaacct actattcgca gatcggttta
     5461 ctgttgctcg ggctaggctt cgctccgatt tatccctgta tgctgcatga tacccccgaa
     5521 cgctttggga aagagcaaac gcaaaagctg atgggctatc agatggcggt tgcgtacacg
     5581 ggtgccacac ttctgcctcc gttgctaggg tggcttgcta cacagacgac cgtttcaatt
     5641 ttaccgtttt ttacagcctt ctacattgtg ttcatactct atggttctga gagagtcaat
     5701 cggatcatga agcaacgggc tgctcagtca gaaacgatct agcatagggc actcgctatt
     5761 ttgacgatag catgttttgc aaagcttttc cgtataaaga caaggggacc tggtcgccgc
     5821 tcatgtaata aaagatggtc atgccattct caagagccag aatcgtccat gccatttcat
     5881 ccgcggatag agtagagtca ctttcttttg gcatcaatgt ctgtatggcc ttggaaagat
     5941 gctgtaccga ctctatgatc atgttcgacc atcgcttgcg aacagattct tcgcgcatgg
     6001 cataaagcaa aaattccagg ttcagcatgt tccacgtgcg attttgttgc tgaacggaca
     6061 taaaataggc gtccatggcc tctataaaat gcgataatga tggctggtga tcaattacgt
     6121 gatggatatt ggacacatgt aattgcattt gaccttccaa aatagcgaga aagagatctt
     6181 ctttggactg gaaatgagca taaacagctc ctttggtaaa accagcatgg tctgcgattt
     6241 tatcaacgga agccccgtgg aagcctaact gagcaaaggt ctcaattgct gcgtctatga
     6301 gcaattgcct tgtttcctgt ttacgctctg cttgggttaa tctgcgtctg ttcattcgtc
     6361 cgcctccttc tcttgacaat cataccatat agaattaaca ttccatatag tatttaaatc
     6421 cttattggta tgtaagatac aaatggcagt tttgtaggat ttaaccgtct actatgtcat
     6481 gctattttgg agtacgatag atatagatca tctagtaaga ggggacagtg tacgaatgca
     6541 gagggaagaa agcgttgcaa cgcggaatcg gcctatgtcc aatattttgg cgcaaacggt
     6601 taagacgggg attatcaaat cgaatctgat tccgatgttt gccggattaa cattggcttt
     6661 atatacgtat cacttcagtc taatagataa gctgccagaa atcttatttg ctacaattgg
     6721 ctctatttta atcatgggcg cagcgggtgc atttaataac gtgtatgatc gcgatatcga
     6781 ttctgtcatg gagcggacga aaaacagacc tacggtgaca ggggaaatat caacgaagac
     6841 agttttatgg ctcgcctcct tgatgacgat ttttggcttg gtggctcttg tgttggcaac
     6901 accgttggct gctattatgg gttttctcgg actgtttttt tatgtcgtgc cttatacgat
     6961 gtggacaaaa agaagaacgg tttacaatac ggaggtaggg agtatttctg gcgcaatgcc
     7021 gccgctcatc ggttgggcag ccattcaccc agatatcaca catcctgcta tcctcggtct
     7081 ctttatcatc atggtcattt ggcagatgcc tcacttctat gcgatcgcga ttcgcaagca
     7141 tgatgagtac aaagcggctg gggttcctat gttgcctgtg gtcaaaggtg caagacgtac
     7201 ctacattcaa acaaatgtct atttggttat tttaattgcc agcagttttc tattctggtc
     7261 attgagcgct ggtcttacgt ttatggccct gctcctgaat attctatggc tggttctgag
     7321 tgtttttgga taccggaaaa tggattctca gaaatggtcg aaaacgatgt ttatttattc
     7381 gctgatccat atgacggtgc tgttctcaac ggtgattatt tactcgctca tggggattat
     7441 cttcaaactg taaatcagtg atcatccaag ctgccttcac tttgagggcg gtttcttttt
     7501 tgtctgggaa tcttgcagca tagctggttc ttctcatgtt caaccaaaaa tgggcgcctg
     7561 atcatggaac aaatacccaa tgtcgcttca taaatttaga gtagctccat gaagtggcgg
     7621 aggtgaagat gaatggatga tttcaaaaaa gagctaaaaa aactaaaggc ttccgaaata
     7681 aaagcggata aagtgcagcc ctgggataaa caaaagatga atgaagcgac gcttgttcgc
     7741 gggcgatgtg gatgtggtag atgtggatgt ggtagatgtg gatgcggccg ttgcgggcgt
     7801 tgtagttgca gttgttcctg tttctgctcc tgtagctgtt cctgcttctg tacgtgcagc
     7861 tgcacttgct tcttcccatg ctttatcgtc taaatggcga tattttctaa ccacgatccg
     7921 aatgaagccc cctgccagaa tgacggattg gcaggggctt tgtttttctt gctggcatgt
     7981 gagacaaagt attctacata aaatgactgt gacacatcat gtagcaaaag ggctgatctg
     8041 gcacaaaaag ggggaggaga atggttaagc tgaatccttc gatgcgcata aaagtgaagc
     8101 gggatacggt ttatctgcct gattcagatg ggagtgtata ctttcggaat aacatcggaa
     8161 catttcgaat gaagggggac atgattgaac gatgggttga ccagctcatg ccgatgttta
     8221 atggtgagta cacgctggca caattgaccg acgatttgcc ggaagaatac caacagcaaa
     8281 tataccaggt agcgggtacg cttttacaaa atggatttct tcaagacatc agtcgagaga
     8341 agccacatga actatcgcca gaaatcatat cggcctatgc ggaacagatt gaatttttgg
     8401 accagtttgg cggatcgggt ggatatttgt ttcaaaaata tcgtacggaa aaagtattaa
     8461 tagttggggc aggttccttt ctcctttcta ttgcccacgc cttgctagaa tcaggctgcg
     8521 ttcaattcca ttatgtcatt acgaatgaag ctcctacgaa gcgggagcga ttagacgcaa
     8581 tcatagagca tgctcgcagg aaagacccgc acgtcaagct ggaggagctc aaaccagcgt
     8641 cgtgggggat tgcggagtgg tcggaggcca ttgagccttt ctctgctgtt ttgtacacat
     8701 cagcgcaagt gaacaaggat gaaataagcg tcattcattc cgcgtgcaga gagaggaaga
     8761 aagtatttgt tcctgccgtt tgtctgatgc aaaaaggaat agccggaccg ttgattcatc
     8821 ccgaatcaga agcttgctta gaatcggctt ggcgtcgttt gcaccgacag accttgtgtg
     8881 cggaccccga tcaacatcca ttctcgatga cggcagcagc gatgctagcg aacgtcgctg
     8941 tgttcgaatg gttcaaacat gttactggcg tcaatgacaa tgaggatgaa aacaaggtgt
     9001 atgtactgaa tctggagaca ttggaaggaa gctggcgatc attcctgccc catccgatgg
     9061 tgaaggaagg aatgaggctg gaggtattgg atagaaagga gcttgaatca cggctatcca
     9121 atgagacgga gccaaaggaa ggactacagt ctctgtttca gtcgtggacc tcatcggata
     9181 ccggaatttt tcacagttgg gatgagggcg agctcacgca attaccgctc acgcagtgta
     9241 atgttacagc agtcgatcct gtctcagaag gcccggcgga gcttatgccg caaatcgtct
     9301 gcccaggtta tacccatgag gaggcacgaa gagaagcggg actgcttggg gcagaaatgt
     9361 acgttggaag aatggtgaac cacctcgcag ccatagattc agcttttcga aatgtaggaa
     9421 atggcaatat cggagtcgga gcaggggaaa cggcagcaga aggacttaat cgtgcactgc
     9481 ggcattgctt gacgcttacg tatgcagcag acatgaaagg gagacagcca acagcgagac
     9541 ctgtccacac tgacacaatt gctgatgaaa gatgccaatt ttatatccgg tcatttacta
     9601 cgttgggtga aaaaccaacg attgcaaagg ggcatgaggt gttcggattt tcggtgtatt
     9661 gggtggaaac gagcacggga tggtacggga gtattggctt gcaggagcga gaggcactgc
     9721 gatcagcgct gatgtatgcc ttgcaacaga ttcagacccc aaccaatcaa atgtccaagt
     9781 atgtgttgac agcgcaatct gttgggttga cgggtgaagc catcgaagtt gcacgcaaca
     9841 gcgttcagaa agaatcggaa aaagaggtct ggaaacaagc tgtcgaggtg ctggcccttc
     9901 atcacctttc tcctcgggta atgaatgccg cgatggagcc tttcctggaa gaagaccttg
     9961 gtggcgtatt cgccttgctg ctctcgaggg aggtgcctcg atgagcgctg acattcttgt
    10021 catcggagac ggtgttttgg cagagctggt ttcagaacgt ttgaggaagg actatcgcgt
    10081 gtggcacagt gaaaacatgg agtctgcgac aagcggagca gatttggctc tcctgttaca
    10141 agatacgtac catcccgctt tgcatttgca ggcagaaaaa cattttcgtc aaacaaatat
    10201 cccgtggctt cgcggctttg tttcatttgg ggaggcaatc gtaggtccgt tggttcttcc
    10261 aggtcaaaca gggtgctccc agtgtgcaga tatacggcga ctgatggcgg gacgcgatcg
    10321 caaagaaatg tggaaggtac aacacatgtt cagcgaaaaa ggcggcatac cgcgtgaccc
    10381 gtggtcatct cgctctgggt tgttacaggt ggcatttcat gtgagtgcgg aggttgaacg
    10441 catagttgag ggcaggcaag cccagttgtc agagcatatc caattcattg atttacaaac
    10501 attgacaagc acacgccact tctttttgcc gaatccgtta tgtccggtat gcagtcggct
    10561 gcctgaggat tctgaagagc aggctagagt acgcttgaag cctattgtaa agcaaagtcc
    10621 ggacagctac cggacaaaac ccatagccga tttgaaacaa gctctcccca ccgaattttt
    10681 ggattcccgt actggatttt tgaatgggaa agtacgtgat cttgtctctg tgttcgcaga
    10741 tgtaagtgtc aatcttccgt tattttcaca tgacgagggt acggccggaa ggtctgtttc
    10801 gtacgcggat agtgagataa cagcgatttt agaaggaatg gaaagatatt gtgggctgat
    10861 gccgcgtggc aagaggacga tggtgcgcga ctgctatgca aaccttgcgc cgcatgcact
    10921 tgatccgacg acagcgggaa cccattcaga agagcagtat gccctgcctg attttccgtt
    10981 tcagccgttt gatcccaagc aagatatgaa ctgggtatgg ggttattcct ttaaagaaga
    11041 gcgacccatt ctagtacctg agctcatggc ctactacagt atgggattcg gggagggagt
    11101 tgtatttgag acctccaatg gctgtgcgtt aggtgggagt ttggaggagg cgatctttta
    11161 cggcatcctc gaagtggtgg agcgagatgc tttcttgatg acctggtatg ccaaattgcc
    11221 attgccgcgc ctcgatccgg cttcggtcaa cgatcgggaa ttgcttctgt tgatcgatcg
    11281 gatgcagacc gttaccaatt acgatttgta cttgttcgat gcgacaatgg aaaatggaat
    11341 tcctgctgta tggacgattg cgaaaaaccg cggagaggca ggcttgcacc tcgtttgtgc
    11401 agcaggagcc catccagacc ccatccgcgc tgtaaaaagc tctattttcg aaacggctgc
    11461 catgctcatg cctttgacag acaagtacga agcgaatcga gacaaatatt tgcgtatgct
    11521 ccatgattca tccttggtga aaaagatgga cgatcatgcg atgctttaca gcttgccgga
    11581 agcagcggag cgcttatcct ttcttatgga tgattcccgc ccgatggtct cattcgctga
    11641 acaatttcct aaaagaaagc agcatcgtga tctaacagac gatttgcggg agttgctcgg
    11701 tgtgttccaa aaattggatc tcaatgtcat tgtggtggat caaacgacac cagaagtcga
    11761 gcgccacggc ttatcttgcg tgcgtgtatt gattcctggc atgctcccga tgacttttgg
    11821 ccatcatctc acgcgagtaa ccggattgaa aagagcattg gaggttcctg taaagctggg
    11881 ttacgcgaaa caaccactgc gtgtagaaga gttgaatcct tttccgcatc cgtttccata
    11941 acatgcatct gggagtgagc cggatgagtc tcgaaaattt tttgtaccgc cttcattttg
    12001 atacagaaaa cgcccgacca agtgatctcg aagtggattg ggaggatgcg ccactgacat
    12061 acaagctgta caggggacta cctgtcattc cactgccaga ggacgtgcct ctatcgctca
    12121 tagatcaaac ggtttcacaa gagatgtctc ttcctcaatt gggtgcttgg ttatggtata
    12181 gctacggact catccaaatc agccaatcgt tgttaaccac gattccggga gatgcaggat
    12241 ctgagtcgtt tttgccgctc gtaacgaatc gaagaccggt tccgtctggg ggagggctct
    12301 atccgagtga gctgtacgtg tatttgaagt tgtcgagtat tcctgcaggt ctctaccact
    12361 acgatgtggc tcatcacaga ctcgtgcgat tgcgggaagg gaattttgat gacgtcctta
    12421 gccgggcgct tggtggccat tgtccggtac atgcatgctt tggagttgcg ttcgtatcca
    12481 tctatttttg gaagaacttt ttcaagtatg atgagttttc ctatcgattg cagggccttg
    12541 atgctggtgt actgctcggg caattgcagg aaatggcaaa ccagctcggt gtgacgaatg
    12601 cggtacatta ccagttccta gatagagcga tgaatgcatt gctgggattg tctgttgatc
    12661 aagagagtgt atacgcggta gtccccttat cgcttcaaac agaaggagag aggcattcgc
    12721 actcacccgc acattgggca gagcgaggag aggagacggc aagcgagcta atccgagaac
    12781 tgcctgagca aaagcatgtg catgttatgc gttcaaaaag aatgagacaa tatcctgtgc
    12841 tcttgcggat gaatgaagct gccatgcagg aatctcccca ttcgtttaca agttattcgg
    12901 atcacttgga aaacaagtgg actcgtcgtt ccgaagagcg aatccttctc ccacggttgg
    12961 agaaaccaag ctatgatctg gcgcaatttt cacgggagcg tttttcaccg gaaatggact
    13021 ttatcaggag gaaaacaggc cgagatcagg tagcgcgtat catggaaatg gcgatgagtg
    13081 ttctatcgta tggcaatgat ttgggaaaaa atcaggaagt agcgtggaga aggctttctc
    13141 tccttgtaag cattcatcag gtagaaggga tacaagatgg ggcatacgct tacgaaccac
    13201 tggagcacgc tctttatccg attgtctatg gagatttacg cgcacgcctt caagacggaa
    13261 tgaccctgga caatgtgaat ttgtatcaag tgccgctctg ctttcatgtg gcgggtaaac
    13321 gcgatcatct gatcaatcag cttgggttta gagggtatcg catccagcag atggaggcgg
    13381 gaatcgtcgt gcatcgcttg cttttggcag cgttcacgtg tggaatgggc ggtcatccgc
    13441 tactcggatt tgacgtaaaa aattgcgatg atctttacaa cctagagaca gaagagaaaa
    13501 cctgcttgat tcaaattccg gtcgggcatt atcgcccccg cgccaggttt cagggcgggc
    13561 ttcatggata aatacgggga agacccgagt caacgctgac ccgggtcttg tattatgtcc
    13621 ttatgatggc tttgatacct tgaatgaagc ggtcaatttc ctcgtgggta ttgtacggtg
    13681 ccagccccgc tcgtatccag ccgccacttt cattgattcc taaacaattg gcgagtgttg
    13741 tcgcatagaa gtccccgtcc gcaacgaata tgctatgctc ctcgcacaat cgctcacata
    13801 tttctcgggg actaaaccct tcgatccgaa aagcgaccgt cggtgttttc ggtacatctt
    13861 cacccgcttg atagagtgtg acgcccttca ttgcgcttag ttcttttctc agcttatctg
    13921 ccagatgatt ttcataggct tcgatcatct cgtaaccaga gcggattttt tcagcaaagc
    13981 tatcaccgaa accgagcgaa gcaacaaatt cgatagcggg tctgattcct gcgattcctt
    14041 catgattttg tgttccggtc tccagtttat ctggataaga agagggggca ggaaccaatt
    14101 tgtaaacatc gagtgcttca aaaatttctt tgcggatgac agcgattccc acatgaggac
    14161 caaaaaactt gtaggctgaa cagagcagga tatcggctcc aatctcgtca cgatggatgg
    14221 agaagtgagg gaccgcatgc acggcgtcga cggcgaaaat gactcctttg gcacgtgctt
    14281 tttgggaaat ggcagcgaga tcatggatcg ttccgacagc attggatgca agcccgactg
    14341 ccacaagtct ggttctggaa gtaaggaggg tatcgagctc atctagctgt aacgtaagtg
    14401 tctctttatt cacctttaac caccgaacgg tcattccgcg atcagcggca acagtcagcc
    14461 acgggtctac attggcgcgg tgatccatct cggagacgat gatctcatcc ccttctttcc
    14521 aatgccgacc tagtgcacgc gcaatcgcaa aggtcagcgt ggtcatattt gcaccgaagg
    14581 ctacctcctt cggcctcacg tggaagaggt ctgctacggc ttgcttggca tctgcaagga
    14641 tggcttctgt ctccttgctc gttggaaagg agccgtgtaa attcgctcca ccgttcgcca
    14701 taaaacgata gatcgcgtcc atagaggatt ttacgacttg cgagccgcct gggccatcca
    14761 gataaacaac tggtttgcct tcgtaggttc gttgtagtgc ggggaattgc tcacggactt
    14821 tttcaatggg gtaatgttcc gatgcaactt ctaatcgcca atcattggaa cgcataaaac
    14881 ttccgggagg gtattcaaag acgcattcag actgcagagt gaaaccgagc ttacggcaaa
    14941 tggcattgga ggcagggttg tctacagagg gataggcatg aataaacttg tgtcttcgtt
    15001 cttggttgat gcgtgtgatg agtgaggcta aagccgcaga ggcgattcct ttcccttgaa
    15061 agggtggcag gacgctccag cctacttcgt atacgtgttc tccttgccag atgcggtccc
    15121 aatagccgat gcttccgaca gggatgtgat ctggcagcag tacgatgctg aacatcttgc
    15181 tggattgctg accgtcctta ttgacgtatc gctcgtgccg ggcgaggagt tgctcctctg
    15241 tctctggacc tccaacatgc tccatcatgg caggcgcatt caaaagatgc agcaagggaa
    15301 gatcgtgatc tgcccagggc tgaatacgaa caagctcagt gttaagcgtt gtggacattt
    15361 tctcactcct tatcaactgg atattcgtgg tgtccaacat cattcggtat ctctcattat
    15421 tcggaaaaga ttccaattaa tcaatctttc attcgtttga gaaagaggga tggaaaatca
    15481 tgctataatg ttagatgccc gagagattca ctgagaggaa ggggtacctg cccatgaatg
    15541 aaaaaagcat ccatacacaa cggcttatat tgattccatt tacacataga atagcgacga
    15601 atattttgca agaaaattac gaagagttat tggatatggg gcttacatta ggcaaaggct
    15661 ggcctgatga ggatgcgatg gaaacgatac ccaaaatcat caaagcactc gaactcgcag
    15721 gggaaccaac aggatttgaa tcgtggatga tcattacaaa agatggtagg aagatcatcg
    15781 gtgatgcagg gttcaaggga gccccgaata cagagggaga agtggacatc ggctatggaa
    15841 ttattgaagc cgaacgaaaa aaaggctatg cgtacgaggc ggcagaaggc ttggcgaatt
    15901 gggcgttgtt gcagccagat gtgaaaaaga ttacggcgaa gtgcttgcta gataatatag
    15961 attccgcaaa attattagtc aaaatgggct tcacagaaat aaagagggac gacaccatga
    16021 tttactggtc tagtcagaag ggataatagt ctacatgaaa attttcaatg gaagggtaac
    16081 ccaagacctc cttgtttcgt attgaaataa ggaaaagatt atcgcttttc attgaactat
    16141 gcaacgcgtg tctctatact gaagagataa gcattggtaa ataattgtga gggataacat
    16201 gcagaactgg atgacccaaa ttattgaaca atatagttac ttcggtatct tactcatgat
    16261 ggcactggaa aacatctttc cacccatacc ttctgaggtg atcttgacct tcggtggatt
    16321 tatgacgacg caatcatcct taacggtttt tggcgtaatc ttgtcagcta caatcggttc
    16381 ggtgatcggg gcaatcatgc tctatggaat cggtttctac ctagacgtcc aaaaaataga
    16441 gaagatcgta gagagatggg ggcatcttct gcgcattaaa acggcagata tccataaagc
    16501 gaatgaatgg ttcgaccgtt acggatactg gacgatcttt ttttgtcgca tgatcccatt
    16561 aatcagaagc ctgatttcca ttccagctgg tatgaccaaa atgaatttcc cgctgttttt
    16621 gctgtttaca acactcggta cgtttatttg gaacatcgtc ctagtgatgg ctggtcattt
    16681 actgggggaa tcgtgggaag acattctgta ctatttcgat ctctattcca atgtcgttta
    16741 tgttgtactc gcttttacgg gggtagcctt tctcattttt ttcctccgca aacgaaaagc
    16801 ggatgcctaa aaccttccaa accatctttc cttcaaggga aggtggtttt ccatttggaa
    16861 ccaacaggta aacatattat aaaaagttgt aattttcttg caaatacaag gtgtcgaaat
    16921 tgcggtaagg tgtagggagg ggagtaggtg acatgggcac cgtccttatt cttgaagctg
    16981 ggggagatgc aacttgatcg atttgttact cgtggacggc gtagtcatta ccatggacaa
    17041 agaccgtcgg gtattacaag acggggcagt cgccatagat aaaggaagaa ttttggaggt
    17101 aggcgacact ccacttctta aagacaagta tcctgcacaa aaggtagtcg actgcgcgca
    17161 tcattgtata ctgccaggct tcgttgacgc acatggtcat ggcggacatt cgctgttcaa
    17221 aacgattgcg acagacaata tcaacgactg gatgccaatc atgaccaaca cttacaagca
    17281 ctacgtgaca gacgatttct ggtactacga gggaaagctg tcagcactgg agcggcttaa
    17341 agctggaatt acgacaggcg ttagcgtact aggctcgatg ccgcgctcag atgatccgat
    17401 ctttgccttg aatcacgcca aagcgtataa cgaggttggc gttcgtgaaa tcgtagcgac
    17461 aggtccttgc aatccgccgt ggccgcatcc ttttagccga tgggtcgatg gacaaaaagt
    17521 aacgaaggaa gtcacgtatg agcaggtgct tgctggagca gaagcagtga ttgaagccct
    17581 gaatcacgca aataacgata aaaccagagc atacataacg ccatttgtca tcgtcacctc
    17641 tgtcaatccg tcctatccga caccagctga ccaattgttt ggcttaaccg attttgaccg
    17701 ttaccaagcg cggaaaatca gggagattgc aaaaaagtac gacacgcgca tccattccga
    17761 tgcttttgga ggcatgattc acctcgcgat tcaagacaaa gagtacgcgc tgctcggtcc
    17821 agacgtgcac ttgcagcatt gtcggggaat ttcttttgac gaggcgaaaa ttttggccga
    17881 aacaggaacg aatgtgagtg cttctcctgg ttttggtcaa atcaatgcac gcactcccat
    17941 tacggaattg ctggagatgg gagcaactgt tgcgatcacg acggacggca cctcgccgat
    18001 gactcctttt gacatgttcc aggccatgcg cagaatgcag ctgctgcaac aagcggcgct
    18061 gcgtgattat tactacctcc cgccgggcaa gctgctggaa atggtcacga ttgatgcggc
    18121 acgctgtgtc ggctgggatg acgaactggg gtcactggaa gctggtaaaa aagcggatgt
    18181 cattaccgta aatatgcatc aggcccactt gaatccggag aacatgcatg tccatcgtgt
    18241 cgtctatcag gcagttggtg gagatgtgaa ccatgtcatt gtcgatggtg agctgattat
    18301 ggacgagcgc cgtgttttga ctgtggatga aaagcaaatc ctcaaagaag cgaatgaaga
    18361 ggcgaaccgc acaatcgagc gggcaggctt agaaatctac atgcagccaa gcaagtattt
    18421 ctgggggcat gcgcgagctt atttggatga gagaagattt gatccgacga agttgtaggg
    18481 gaaaaagagt ggataaacga agacccatgt aatgctgcac aaaaaactag gttaccgcat
    18541 tgaataggag aaggtgcccg ccgccttccc ttttttatgg attatagttg acaaaaacga
    18601 taggattaat cattatttat tcataatccc catcgacaaa gttggaataa aaagaggtgc
    18661 agtcatgtat ctgactattg ataatgttac gaaacatttt gagaatgagc agaaacaaaa
    18721 agtaaaggtg ctggatgata ttaatcttga agtggaaaag ggcagcttcg tttccattgt
    18781 cggcccctct ggctgtggta aatcgacgct gctctactta atagccggat tggatcgacc
    18841 agacagcggt gacatacacg ttgctggcaa caaagtgaat aagcccggtc ccgacagagt
    18901 cgtcgttttc caagaagcgg gattatttcc atggctaact gttttggaaa atgttacata
    18961 cgggctcaag ttgaagaaaa tgtctgcagc gaaagccaac gaaaaggcgc tggaagtgct
    19021 caaaatggtc catttaagca agtatgttca ttcctatccc catcagctct caggcggaat
    19081 gaagcaacgt gtagccatag ctcgggcact tgtcatggaa cccgatattt tgctgatgga
    19141 tgaaccgttc tcggcgctgg atgaacagac gaggatggtt cttcataagg agttgcttga
    19201 gatttggcgg acgaccaagg tcacgatttt tttcgtgacc cataatatcc gagaggccgt
    19261 tcagcttggg gagaagatcg tcgtttttgc cacacgcccc ggcaaaatca aggagatcat
    19321 tgcagttcct gccatgcgcg atggagtcat gccggacagt gtgacattaa gcaccgagca
    19381 gaaggtgctg tcgatcctgc aagaagagat agaaaaggtg ctgaaggagg aaatgggcaa
    19441 tgactacagc tttaagacgg gtcatcttca tcgctatgat agcggcgatc tgggaagtca
    19501 catctagatt atctgggctc ccatcgttca tgtttcctag cttgacccag gttttcgaaa
    19561 cactcgtaaa tggcttgata agcgggcaaa ttaccgctgc gattggaaaa agcatgggac
    19621 gaatcctgtt gggctttctc attgccatta tcgtcggact gatattgggt tacttcattt
    19681 ggaggtacaa actcgtagaa gatacgcttg gctttgtggt gacagcgctt cagtctatcc
    19741 cgagcattgt ctggttcccg cttgcgatta tctggtttgg cttaaatgac ttctccattt
    19801 tgttcatcgt gacgatcggg gcgacctgga cgatgacggt caatgctacc agcggtttca
    19861 aaaatgtccc gccgctatat caacgagtcg ccaagacata cggttcgtct ggctttcact
    19921 ttgtacgaac agtcattctt cctgcttccg taccgcagat catctccggg cttcgaatcg
    19981 cttgggcatt ttcctggcgg gcacttatgg ctggtgaatt gctcgggggt ggcggtggtc
    20041 tcggtcaatt gctcgagatg ggacgttcac ttggacaaat ggatttggtg atatcagtga
    20101 tgatcattat tgcgatcatc ggtaccatcg tcgataatgt tgtcttttca cgcatcgaac
    20161 gcaacgttca gatgaagtgg ggagtccatt cataaaagaa aaatggccta aggagtgtgt
    20221 cgtcacatgc ttaaaaaagt gctcagtacc gttgtcgcat ccctattgtt gatgggggtt
    20281 gcgagcgggt gctctactgg aggagcagaa tcctctgaga aggaagtaag gatcggatat
    20341 ttcccaaatc tgacccatag cgcaacgatt atcgcgctgg agaaaggcta tttcaaggaa
    20401 gcttttggtg cggatgtaaa gattcaaaca aaaacggtca ccaatggcgg attgtttatg
    20461 gaagcgatgg caaccaaagc aattgatgta gggacagtcg gacctggacc gctgttgaac
    20521 ttttatgtga agcaccccgg gtatcgcttg atttcagggg cggtcaatgg cggagctgtg
    20581 ctcgtcatga atggttcaac caatattacg gaactaaaag atttaaaagg caaaaaaatc
    20641 gcgattccgg ttatcggcag cacacaggat gtcatgctta gaaaagcatt gaatgaggtt
    20701 ggtctcaaac cgacgacgaa tggtggagat gtggaactgt atgctgcggc tccagcagat
    20761 acggcagcat tattcgtgca aaaatccgtt gatggtgcag caactcaaga gccatgggga
    20821 tatgtactgg aaaatcaggc agaaggaaaa ttgcttttgg actgggatca attcgcttgg
    20881 gggaaagaat caaccaatac tgtcgtagca gccagcgatg aatttttgaa acgagaagga
    20941 ttggcaaccg cctacctgca agcacataaa aaggcagtca aattcattca ggaaaatccc
    21001 gaagaaagcc aagacctgat catcaagcat ttgaaaggtc tgactggcaa agaactgagc
    21061 aaaaaagaag tgcaggcagc cttttcccgt ttggaagtaa caacggcggt caatgaaaaa
    21121 gtcattcagg aaatggccga tatcagccag gaagccggct atatttccag taataagatc
    21181 gatggtttga ttgatttaaa atatttggaa gcggtgaaat aatatcgagt gagaaggagc
    21241 gagattagca ggaggaacgg gggatggaaa ggaattagat gggaaaggag gtcatgccgc
    21301 gatgagacca catgaacaag gaagtaatca accaaacgac acttcattgg agacgcagat
    21361 tcatactgat ttccaaaaag agatgacgta cggcgattat ttacagctcg atcaaatctt
    21421 gtcgagtcaa caatgccaat ccagccatca tgatgaaatg ctgtttatta tcattcatca
    21481 ggtgagtgag ctatggatga aacaaatttt gcatgaactg tcagcagcaa atgagtgcat
    21541 ctgcaatcac gatctggagc ctgctttcaa aatgttcgcg cgagtctcgc gtatccagca
    21601 gcaattgatt aaatcgtggg atgtcctttc tacattgacg ccagcagact acctccagtt
    21661 ccgtgacaag ctgggtcatt cgtccggttt tcaatcctat caaaaccgac tcatcgaatt
    21721 tacgctaggt tataagaacc agcatgtcct ggcggtgtat gcgcatcaac cggagcttca
    21781 cgcccaaatg agtgcggcct tgcagcagcc tagcatttac gatgcggcga tcagggagat
    21841 ggctgctcgt ggcttgccga ttgatccgga atgcttgaat cgcgattggt cacagccata
    21901 ccaacccaat cagagtgtag agcaagcctg gctgaccgtg tatcgaaatg tgaaccagta
    21961 ttgggatctg tacgagttgg cagaaaagct ggtggatatc gccagtcagc aacagcaatg
    22021 gcgttttaac catatgacga cagtcgaacg catcataggt caaaagccgg gaacaggagg
    22081 gtcatcaggc gtcatgtact tgcgtagagc gctcgatcac cgttttttcc cggagctgtg
    22141 gagcttgcgg actctgttgt agaaaaattc atcaaaaaaa gcgagaaaag cgtcttgggg
    22201 acccagggcg ctttttttcg tgtagtactc atttcacatc ttttcacata tccttcctaa
    22261 tattgggtac aaataccctt cttttcctga caaacatatg ttttcatttt tactagtata
    22321 catatttttc aagaacaaca agaaatggag tgggcacttg gatggaaaca atgaagccac
    22381 ctatggaagt gttatatgcc aaacagctga atgcactgcg atcccatgat acagggacaa
    22441 aacctcccaa ttggctgatg tctcccagag ctgtgcgcga ttttatttta ggaacagatg
    22501 aacccctctc ttatgagggc gaaagtataa cgattacgaa gaagttttat ggagacgatg
    22561 tgcttattga gcgtgcaatc gtcacgttgg caggcaatcg cggcttgatg ctcgtcggtg
    22621 aacctggaac ggcaaagacg atgctgtctg agctgctgtc tgcggccatc tccggaacga
    22681 gcacgaatac gatccaaggc accgcaggaa cgactgagga tatgatcaaa tactcctgga
    22741 actacgcgat gctgctggac aaaggtcctt cgctgcaagc gctggttcct tccccgttat
    22801 acaccggaat gagcaaggga atcattaccc gttttgaaga aattacccgt tgcccgtttg
    22861 aggtccaaga cgtgttgatt agtattttga gcgacaaggt gatgaacatc cccgagctgt
    22921 cagacggcat cctgtttgcg aagcccggtt ttaatatcat cgcaacagcg aatctgcggg
    22981 acaaaggcgt caatgaaatg agcagcgcgc tcaaacgccg ttttaacttc gagacaatcg
    23041 cgccgattaa tcatgtgaaa atggaagcac aaattatcga atcccaagca aaagtgattc
    23101 tggagcaaag tggcgtaaac atcgaaatcg atcgggatgt ggttgagata ttggcgacga
    23161 ccttcatgga actgcgcatg ggcgagacca aggaaggttt caaaatcgat tccccccaat
    23221 ccgtgatgag tacagccgaa gccgtatccg tctatgtcca aagtgcgatg acgtcccatt
    23281 actatgatgg caggcccatt tctatggatc gattggtgca gaacatgctg ggagcggtcg
    23341 tcaaggaaaa ccagaaggac gcaaatatcc tgaaaaccta ctttaccaaa gtggtcaaag
    23401 aacgggcaaa ggaagagggt ctatggggaa cgtattacaa cgagaagaaa tggatcaaat
    23461 aaacagtcag gaccgcttca taaagtcatt cgtcgaagaa gaggtctaca acctcagcaa
    23521 acaggttgtc tatttcccgg ttcgtcatca tagtcctgcc tgcgcgtttc a
//
