LOCUS       NZ_CP048835            22601 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. So13.3 chromosome, complete genome.
ACCESSION   NZ_CP048835
VERSION     NZ_CP048835.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. So13.3
  ORGANISM  Streptomyces sp. So13.3
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K., Quezada-Solis,D., Khalil,Z.G., Capon,R.J.,
            Andreote,F.D. and Barrientos,L.
  TITLE     Genomic and Metabolomic Analysis of Antarctic Bacteria Revealed
            Culture and Elicitation Conditions for the Production of
            Antimicrobial Compounds
  JOURNAL   Biomolecules 10 (5), 673 (2020)
   PUBMED   32349314
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K., Lamilla,C., Abanto,M., Maruyama,F., Jorquera,M.A.,
            Santos,A., Martinez-Urtaza,J. and Barrientos,L.
  TITLE     Antarctic Streptomyces fildesensis So13.3 strain as a promising
            source for antimicrobials discovery
  JOURNAL   Sci Rep 9 (1), 7488 (2019)
   PUBMED   31097761
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K. and Barrientos,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2020) Centro de Excelencia en Investigacion
            Biotecnologica Aplicada al Medio Ambiente (CIBAMA), Universidad de
            La Frontera, Av. Francisco Salazar 01145, Temuco, La Araucania
            4811230, Chile
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-JAN-2020
            Assembly Method                   :: Unicycler v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 140.0x
            Sequencing Technology :: Illumina MiSeq; Illumina HiSeq; Oxford
            Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005860785.2-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 04:03:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,707
            CDSs (total)                      :: 8,616
            Genes (coding)                    :: 8,274
            CDSs (with protein)               :: 8,274
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 342
            CDSs (without protein)            :: 342
            Pseudo Genes (ambiguous residues) :: 0 of 342
            Pseudo Genes (frameshifted)       :: 109 of 342
            Pseudo Genes (incomplete)         :: 268 of 342
            Pseudo Genes (internal stop)      :: 24 of 342
            Pseudo Genes (multiple problems)  :: 52 of 342
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:45:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9293334
            Orig. end                         :: 9315935
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048835.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Laboratorio de Biologia
            Molecular Aplicada, Universidad de La Frontera, Avenida Alemania
            0458, Temuco, Chile.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22601
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="30"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22601
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22601
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12601](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12601)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            15..662
                     /locus_tag="C8250_RS41595"
                     /old_locus_tag="C8250_041650"
     CDS             15..662
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556074.1"
                     /locus_tag="C8250_RS41595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041650"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_138355326.1"
                     /transl_table=11
                     /translation="MHIKDDDTLLFIGDSITDAGRDRADPASLGQGYVREIARTLRERA
                     HDGPGPRIINRGINGHRVYDLASRWSTDVIDHRPTVVTVKIGINDTWRRYDRNLPSPVD
                     EFEACLDRLLADTASKLSAQLVVITPFLLPVGPDQERWFEDLSPRTDAVLRAAVNNGAQ
                     VVRADLVLPRAAQDREPAELAPDGVHPTPLGHRLIADAWLAEVAPTTPHGRR"
     misc_feature    complement(822..835)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.08"
                     /tool="antismash"
     gene            898..1431
                     /locus_tag="C8250_RS41600"
                     /old_locus_tag="C8250_041655"
     CDS             898..1431
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554273.1"
                     /locus_tag="C8250_RS41600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041655"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_138355327.1"
                     /transl_table=11
                     /translation="MERDAVDLIVEQWARVRPDLDASPVNVLGRLSRVTRIVEREFQAL
                     FSEFGLQMGEFDVLGTLLRAGPPGGMTAGELTRHSMKTAGAITNRLDRLVAKGYVTRDL
                     DPANRRTVIVALTPAGRELIDRVIGAHLDNSRRILAALDPHRQGDLAATLRTLLISLGD
                     QANDTSDVRLAGEA"
     gene            1726..2136
                     /locus_tag="C8250_RS41605"
                     /old_locus_tag="C8250_041665"
     CDS             1726..2136
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521381.1"
                     /locus_tag="C8250_RS41605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041665"
                     /product="DUF3291 domain-containing protein"
                     /protein_id="WP_138355328.1"
                     /transl_table=11
                     /translation="MPTLRWTTPNSPEGHESALIMASRFEVRSLKDVPRFFLNSLAAWR
                     QVRKAPGCFGASLVARPVKRTFQTLSAWESREQLMTFVQTEPHRSIMKAMRSTMSDSTF
                     VFWDASVADLPISWAEAERRLDEMATKEAQER"
     gene            2486..2998
                     /locus_tag="C8250_RS41610"
                     /old_locus_tag="C8250_041670"
     CDS             2486..2998
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024100.4"
                     /locus_tag="C8250_RS41610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041670"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_198358676.1"
                     /transl_table=11
                     /translation="MTTDVTPELAEAIQRGYDQRDRANMAPTIAYFQALLAEHPDHPVL
                     VYEVGGAYDTAGLEETARGYYERALALGLDGDALRRCLCQYASTLRWLGELDTSLVVLD
                     RARREFPDSDSVRVFRALTLNDAQRPDEAVAELLTVVTGHAEVTDLGRWAVGLSGLAQW
                     LADGRPE"
     misc_feature    complement(2511..2525)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    3472..3485
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.15"
                     /tool="antismash"
     misc_feature    3785..3799
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     gene            3811..4695
                     /locus_tag="C8250_RS41615"
                     /old_locus_tag="C8250_041675"
     CDS             3811..4695
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359915.1"
                     /locus_tag="C8250_RS41615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041675"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_138355329.1"
                     /transl_table=11
                     /translation="MSTPLGVTLRPYTPADQTAVLHLINADRLPGQPPTTPAMLHQALE
                     GRSPVDAQWWAALDQPTTEVVVEDTGAVFGVVSYAVRPKDDTGVILWLHCGEAARTADL
                     LIRRAVAALAPRPVQAFQIASALSLGLEALPVRNRAVTDEALRRAGFTGERLWRYLRAA
                     LPTPGLPHAAHVHIGRADDTGKNTRRLEIRNGPDVVAEAVVGPPVHGIGVLWRIEVAPS
                     ARGQGLGRALLGSALDVLTGLGATEVILYVDDDAPAGDDRDRTATNRLYDSAGFIEIDQ
                     LHSYTLARTGHPR"
     gene            complement(5160..5897)
                     /locus_tag="C8250_RS41620"
                     /old_locus_tag="C8250_041680"
     CDS             complement(5160..5897)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320629.1"
                     /locus_tag="C8250_RS41620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041680"
                     /product="VOC family protein"
                     /protein_id="WP_138355330.1"
                     /transl_table=11
                     /translation="MATRLVQINMKAQDDSVLGRFWAEALGWGVDSEGPGVTNLEPVGF
                     VYPDPVAVCIDIVARPEPKTVKNRVHLDLATTSTAHQAELVARLKDLGATLADVGQGDV
                     PWTVMADPEGNEFCVLEPRPIYQDTGPIAAVVVDCTDPRGMARFWGETMDWTLHEVTDD
                     HATMRSAKGVGPYLEFLRTPDTKSVWNRVHLDVCPYPGDDLGAEEARLRALGATDPGID
                     RSAISWTVLADPEGNEFCLLSPR"
     misc_feature    5892..5902
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    6854..6871
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(6893..7360)
                     /locus_tag="C8250_RS44245"
     CDS             complement(6893..7360)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS44245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_232485874.1"
                     /transl_table=11
                     /translation="MTIMVVPSSEAVGCHTKARQMPLAWFSPEEMFRHANALSARCHCP
                     VTGTAGSVHVSCDGAKAVTALDAFVDLLVAFTGAGDQRPWPSMDVQFRVVWVLLRPAVF
                     SLIVMGGERFSQVGTVSAYNAFDCFGQIVQEVPGVGHLLGLRGARLGSVTE"
     misc_feature    complement(7145..7147)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7350..7766
                     /locus_tag="C8250_RS41630"
                     /old_locus_tag="C8250_041690"
     CDS             7350..7766
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602261.1"
                     /locus_tag="C8250_RS41630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041690"
                     /product="hypothetical protein"
                     /protein_id="WP_138355332.1"
                     /transl_table=11
                     /translation="MIVTKRHSLRIAVVSAIAAASVALAGTAAMAATPATASTSVAQKS
                     LAAKATISAKPSVGSVKAWQLFRVTGTTTGLKAGTKVTLQQRQGSKWVMLPASVPVARN
                     GAYSLGVKLGLKGKNSLRIVSGNTASPVFNVTVR"
     gene            complement(7931..8656)
                     /locus_tag="C8250_RS41635"
                     /old_locus_tag="C8250_041695"
     CDS             complement(7931..8656)
                     /EC_number="3.5.1.-"
                     /GO_function="GO:0019213 - deacetylase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557512.1"
                     /locus_tag="C8250_RS41635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041695"
                     /product="PIG-L family deacetylase"
                     /protein_id="WP_138355333.1"
                     /sec_met_domain="PIG-L (E-value: 2.6e-26, bitscore: 91.8,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQLTPMPDDWQRALAIVAHPDDLEYGAAAAIAQWTAAGREITY
                     LLVTRGEAGIDGLEPKESARIREAEQRASAAVVGVTAVEFLDHPDGVIQDGLELRRDLA
                     AAVRRHRPELLITLNHHDTWGGTAWNSPDHRIVGRATLDAAGDAGNRWIFPDLPDAPWD
                     GVRWVAVAGSPQATHAVEATPSGAERAVASLAEHRAYITALSDQSPKDYAQSFLQGMLD
                     MAAPRFGGVPAVTFQVYPR"
     gene            complement(8900..9397)
                     /locus_tag="C8250_RS41640"
                     /old_locus_tag="C8250_041700"
     CDS             complement(8900..9397)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063905.1"
                     /locus_tag="C8250_RS41640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041700"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_138355334.1"
                     /transl_table=11
                     /translation="MQPTQITEILNRPISQDLLARDLTRLAYVATDGTPRSIPIAFTWN
                     GSQIVLCTTKNAAKLPALRKNPIVALTIDTEVHPPKILLLRGRAELDVVDGIPEEYLQM
                     NGSYAMTPEQRTEWEAEVRSLYDGMVRIVITPTWAKLIDFETTLPTAVEELIRQRAERQ
                     CT"
     gene            complement(9860..9988)
                     /locus_tag="C8250_RS44610"
     CDS             complement(9860..9988)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS44610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_269287099.1"
                     /transl_table=11
                     /translation="MNQILALQELTVEVDAEQEGAFWPPCFSIHESLWTNPTTTTM"
     CDS_motif       complement(9923..9988)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNQILALQELTVEVDAEQEGAF"
                     /locus_tag="C8250_RS44610_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9860..9922)
                     /prepeptide="core"
                     /locus_tag="C8250_RS44610_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-3.00"
                     /molecular_weight="2223.5"
                     /monoisotopic_mass="2222.1"
                     /core_sequence="WPPCFSIHESLWTNPTTTTM"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNQILALQELTVEVDAEQEGAF"
                     /leader_location="[9922:9988](-)"
                     /alternative_weights="2241.5"
                     /alternative_weights="2259.5"
                     /alternative_weights="2277.6"
                     /alternative_weights="2295.6"
                     /alternative_weights="2313.6"
                     /alternative_weights="2331.6"
     gene            complement(10001..12601)
                     /gene="lanKC"
                     /locus_tag="C8250_RS41645"
                     /old_locus_tag="C8250_041705"
     CDS             complement(10001..12601)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="C8250_RS41645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041705"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_138355335.1"
                     /sec_met_domain="micKC (E-value: 5.3e-148, bitscore: 493.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 5e-12, bitscore: 44.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.7e-13, bitscore:
                     46.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDAIGMALAGQEFYAPLATISDTGQRLAPAQVADGWLSTGKDIW
                     TAWSHPSLRRAAQGWKIHVSARLDRTQDVLDAVAHTCFAERVPFKHVSAQKFFLALHHK
                     HADRAQAGKFCALYPQDTETAHRLLAVLSAALEGEEGPYILSDRRYRDSRTVHYRYGAF
                     SHRSRLRLDGSREPVIRDGFGRDVPDQRRPVFILPDGVTDPFVAQEPAPHSGPIVIRHY
                     EIAKVLQPSNAGGAYQAVDRRAGRAVFIKEARAHNGYTWDGVSARQRLRREYDVLTAVH
                     AAAPGVCPQPLDHFTEWEHDFLVTEFVDGISLHHWVARNSPTTKAEWPNRDSASYFKAC
                     RQILRSLDESLSHLHSRGYRFGDLSPANVIVTADLRARLIDFEAATPLTQPAAAMGTPG
                     FTLPRGLADADTDPLLHDRYAMAALTLSLFAPPLQGAAERQSSQLALLRRDLTATAAVP
                     ADLWARATAFQRTDGGSSAALPDPSDVDADPEGCLADLAARVAIGLLDAADTRRSDWVF
                     PPSPQAFHTNTVGVAYGTSGVVHALHRAGVPIPEEIEKRLLVDSLALRDELPPGLNAGS
                     AGIARVLAQLGRLDEATELLQTAENHPLTRTSTTLADGRAGIGLSWLALHRRTRDNRHL
                     ELAAAAGDAIVRTTDLVPTLGDHDARGLFHGRSGLALFLHQLADATGRTSYLTAGRHLI
                     HEELDRALQLPDGGLSFADNAVIRRAMPYLSVGSAGVATVLTRYVATSPDDRCVAALPL
                     LVADARKTCAMEPGWSTGLAGLTYFLAEHAELTGRPTDREAAVRVATGLLKHAQPHGQG
                     VRYLGAGGMRCTADLTWGAAGVLLALQRVLHGPEDELFTLDHGHPIHPEVPSRK"
     misc_feature    complement(10931..10933)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13763..14113
                     /locus_tag="C8250_RS41650"
                     /old_locus_tag="C8250_041710"
     CDS             13763..14113
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS41650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8250_041710"
                     /product="hypothetical protein"
                     /protein_id="WP_138355336.1"
                     /transl_table=11
                     /translation="MKTSGKKKPLSEDLKVLDADLAVAADMIAGNAATSLRDGRWVDLV
                     VDLVEANRRTQISLHEAVEKALAHGQSFESLAAGSHLSAEYLQEAYEQFDRAAVARPGP
                     DKDGREPWRVLG"
     gene            complement(14194..14451)
                     /locus_tag="C8250_RS41655"
                     /old_locus_tag="C8250_041715"
     CDS             complement(14194..14451)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS41655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8250_041715"
                     /product="hypothetical protein"
                     /protein_id="WP_306665041.1"
                     /transl_table=11
                     /translation="MRPTRQAGAGCRHGPSTDRRVSTLQVWDDYEWSWTGSLSQWALDH
                     PEHPDNGEALKAAAEHRHTWLHGYRGTLGFVTLLLRRTNC"
     gene            complement(14531..15286)
                     /locus_tag="C8250_RS41660"
                     /old_locus_tag="C8250_041720"
     CDS             complement(14531..15286)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607278.1"
                     /locus_tag="C8250_RS41660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041720"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_307811561.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 5.3e-08, bitscore:
                     31.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWPALISWPRPPAFTPPPSRSSPRSPDQPSHHKESPMSTIGILGT
                     GRVGSNLARALAAAGHTVILGHRTPDAAAAGKEAGMDPSIRFADQRATARAADIVINAT
                     PGDSALERLTELRTELADKILIDVSNATHDAADGLPGDLVYPGSSLAENLQQALPDTRV
                     VKTLNTMLFMVMTSPHTLATPPTVYLSGEDDHAKKTVGALLGDLGWQPEWIENLGGITT
                     ARATEALILLVPHIVRRHGFQPFAVSLTR"
     gene            complement(15207..16019)
                     /locus_tag="C8250_RS41665"
                     /old_locus_tag="C8250_041725"
     CDS             complement(15207..16019)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471331.1"
                     /locus_tag="C8250_RS41665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041725"
                     /product="inositol monophosphatase family protein"
                     /protein_id="WP_138355338.1"
                     /transl_table=11
                     /translation="MSFDTSFDLDNSLLATVTSIVRTAGDTLLDRFTTHARGTALDEIV
                     KEIYANDDAVLKVMREPLLLARPGSQWAEDELAGGALPDGEWWIVDPAEGNINHVHGMP
                     DWAVTATLVRDNQPVLTVVHLPLTGDTYTAIAGRGAHLNGAVLRASAKTDLGAALVGTG
                     QAKPGEDADTFRKIGESVTAMLINGLVVRVSVPATLQLIHLAAGRMDAFWQFSDVRSGL
                     VAGALLAIEAGGTVTDISGAPWNLASPDFLAAAPGLHAAAVTVLAPLA"
     misc_feature    16130..16143
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.37"
                     /tool="antismash"
     gene            16143..17075
                     /locus_tag="C8250_RS41670"
                     /old_locus_tag="C8250_041730"
     CDS             16143..17075
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1125: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987654.1"
                     /locus_tag="C8250_RS41670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041730"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_138355339.1"
                     /transl_table=11
                     /translation="MHLDLNLLTALDALLEEGSVSGAAARTHVTAPAMSRSLGRLRKVT
                     GDQILVRSGHTMVPTTYALAVRAQVHDLVQQAHEVLSPDREVDLSTLERVFTVRWHDAL
                     ADACGPALLATVHRQAPGIRLRFVAEPSADTPDLRRGDVDLESGTGTPAAPDVRHRQIG
                     QDRLVVAVRPGHPLAGAPLTVERYVAAEHVTVSRRGRLRDPVDDVLASLGMERVVVAAA
                     PTASTALRLVHGTDLVVSVPEASTRAARRQLGLLALPVPMQLPPIGLYLAWHRRHDNDR
                     AHTWLREQARTVLQALFAEPTTPERQPTR"
     gene            17934..19289
                     /locus_tag="C8250_RS41675"
                     /old_locus_tag="C8250_041735"
     CDS             17934..19289
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655167.1"
                     /locus_tag="C8250_RS41675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041735"
                     /product="radical SAM protein"
                     /protein_id="WP_138355340.1"
                     /transl_table=11
                     /translation="MHDDGMNHSNQRFHVIVLSNFAKGFDKYAFAYGKAGIPESTYPDR
                     FHLLTRAELGIGIAKARRLLDRLAIPGDRVLVLETTVDPDKLVSNVSTGLGMELHEDRI
                     RLSEVHELDQVGDEFTLRPTTVEDAMAASLHLHGSAQRRYADTRPRSVSLLPVASACQA
                     RCSFCFSSASISSDQAPARVPWDAVAHWLERARAAGAERAVITGGGEPTLIPFEQQLRL
                     VSACSAAFPKVVLITNAHTLAKGRHADRAGRLAALSAAGLSVLAVSRHHQDDAVSERLM
                     MLRTPVASVIDTWRVERDRWPGLRMRLICVLQHGGVADAADVADYLSWAAALGVEEVCF
                     KELYVSTSTESLYFDRAANVWSREHQVSLSIVTRFAERHGLELESRLPWGAPVYHGSWD
                     GRPMRIAAYTEPSLLWERTNGIARSWNVMADGRCYASLEDRASEIVPEGATA"
     gene            19286..20302
                     /locus_tag="C8250_RS41680"
                     /old_locus_tag="C8250_041740"
     CDS             19286..20302
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (38-315). E-value:
                     9.6e-07. Score: 20.1. Matches aSDomain:
                     nrpspksdomains_C8250_RS41680_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009316412.1"
                     /locus_tag="C8250_RS41680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041740"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_138355341.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 0.00014, bitscore:
                     20.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFDEFQEFRQRQLSASSSLLDAADTNVYRALAPMRPEPPTDMTT
                     VYRCDLARAWLRRFELPEEWSGHAMVCRGVRHGLGVVFHWLRAVQARLWLPSDVYPVYF
                     ELARAAGLEPASYPTLPAPALPRSPADDRPEYLLLANPSKPLGRYLSDGECDAVISWLL
                     VSPRRRLLIDSVYDLGAPFAAGTRRLLDTGRAVLLHSVTKGWLWPRTFGVVLLGPGQVE
                     LAEAFRADPPTSAQLRLAGRLLTEHSDVPRQVVDELAARAERLFERLPDEVLGAIPTAS
                     RTCPGNYFFPVEIPAQTLQRECGVLAMPVSVFGESRWSGSVLTSLADAFGPTPAVAR"
     aSDomain        19400..20230
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8250_RS41680_Aminotran_1_2.1"
                     /evalue="9.60E-07"
                     /label="C8250_RS41680_Aminotran_1_2.1"
                     /locus_tag="C8250_RS41680"
                     /protein_end="315"
                     /protein_start="38"
                     /score="20.1"
                     /tool="antismash"
                     /translation="PPTDMTTVYRCDLARAWLRRFELPEEWSGHAMVCRGVRHGLGVVF
                     HWLRAVQARLWLPSDVYPVYFELARAAGLEPASYPTLPAPALPRSPADDRPEYLLLANP
                     SKPLGRYLSDGECDAVISWLLVSPRRRLLIDSVYDLGAPFAAGTRRLLDTGRAVLLHSV
                     TKGWLWPRTFGVVLLGPGQVELAEAFRADPPTSAQLRLAGRLLTEHSDVPRQVVDELAA
                     RAERLFERLPDEVLGAIPTASRTCPGNYFFPVEIPAQTLQRECGVLAMPVSVFGE"
     gene            20299..21108
                     /locus_tag="C8250_RS41685"
                     /old_locus_tag="C8250_041745"
     CDS             20299..21108
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017238.4"
                     /locus_tag="C8250_RS41685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041745"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_138355342.1"
                     /transl_table=11
                     /translation="MRPLQDLAVYDDADFYDQEFAARTHDIPFFLGQAVRAGGPVLEVA
                     CGTGRITLPIARAGIEVTGLDIMPSMLARARQRAEDERLPVEWLEQDCRDIRSDRRFAL
                     VFSATNAMQHLHDLDSVVAFLTSARNVLRPGGTLILDVFNPDMAKLCRLPESPYHHKSV
                     VDRDGARLDVRAATSYDAAAQVLRFTLDYLRDGVCVRTKKVSMRCFFPEELSALCRLAG
                     LDVAQRYGDYDQSPFTSTSPKQLLLCRSRTANGQIGDPPSVPVMPPS"
     gene            complement(20997..21554)
                     /locus_tag="C8250_RS44250"
                     /old_locus_tag="C8250_041750"
     CDS             complement(20997..21554)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="C8250_RS44250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_041750"
                     /product="rRNA adenine N-6-methyltransferase family
                     protein"
                     /protein_id="WP_269287104.1"
                     /sec_met_domain="PCMT (E-value: 2e-13, bitscore: 49.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLSTATTSGASPRLTTPCSPIHATHRGSSPDPGPGRRNCAGRR
                     DEHHLDSGPDDTVLEIGTGSGYSTALLAHRVRPDGLVTVESDPHLADRARTALAGRGLR
                     PAVVTADGEQGYPARAPCTRTRRRQRGSPLMRPPTRHVDRNVVPAQLGGMTGTDGGSPI
                     WPLAVRERQSRSCFGEVLVNGD"
     misc_feature    22406..22420
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 ccaggacggc agacatgcac atcaaggatg acgacacgct cctgttcatc ggggactcca
       61 tcaccgacgc gggccgcgac cgtgcggatc ccgcatcgct cggccaggga tacgtccgcg
      121 agatcgcgcg gactttgcgc gagcgggcgc acgacggacc cggcccccgc atcatcaaca
      181 gggggatcaa cggccaccgc gtgtatgacc tcgcatcccg ctggagcact gacgtcatcg
      241 accaccggcc caccgtcgtc acggtcaaga tcggcatcaa cgacacctgg cggcgctacg
      301 accgaaacct ccccagtccg gtcgacgagt tcgaggcgtg cctcgaccgc ctgctcgcgg
      361 acaccgcgag caagctgtcc gcacagctgg tcgtcatcac tccgttcctg ctcccggtcg
      421 ggccggacca ggaacgctgg ttcgaggacc tgtcgccgcg taccgacgcc gtcctgcggg
      481 cagctgtgaa caacggagcc caagtggtcc gcgcagacct tgtcctgccc cgcgcggcgc
      541 aggatcggga gccggcggag ctggccccgg acggcgtcca cccgacccct ctggggcacc
      601 ggctgatcgc cgacgcctgg ctcgccgagg tcgctcccac gaccccgcac gggcggcggt
      661 agcaccgccc cagaagagac tgccccgaac cctgcacgcc ggctggggcc cagggacggc
      721 ggggtgatcg tgattcggca tcaggccgca gggtgtcacc gatgagggca ggcgcggtga
      781 tcgcgggcgg tgactcggcg cccatgaaag gcacttcgac gttcaaataa ttgacgttga
      841 ggagcgtgcg tcacggtggt aatctcacgt cgaacatttc aacgttgagg agtcctcgtg
      901 gagcgtgacg ccgtcgacct catcgtggaa cagtgggctc gcgtccgccc cgacctcgac
      961 gcgtcccccg tgaacgttct cggccgcctg tcacgggtga cccgtatcgt cgagcgcgag
     1021 ttccaagcgc tcttcagcga attcgggctg cagatgggcg agttcgacgt cctcgggacc
     1081 ctcctccgcg ccggcccacc cggcggcatg accgcggggg aactgacccg ccactcgatg
     1141 aagacggccg gtgccatcac caaccggctc gaccggctcg tcgccaaggg ctacgtcaca
     1201 cgcgacctcg accccgccaa ccggcgtacg gtcatcgtcg ccctcacccc cgccggccgc
     1261 gagctcatcg accgtgtcat cggcgcccac ctcgacaatt cacggcgcat cctcgccgcg
     1321 ctcgatccgc accggcaagg cgacctcgcc gctaccctgc gcactctgct gatcagcctt
     1381 ggtgatcagg cgaatgacac gagcgacgtc cgcctggcgg gcgaggcttg agtcactggc
     1441 ccccgagcag tccgttccgc cagggcatcc ccgccgcttc ccttctcgcc ctcgaacctg
     1501 gccgcaatcg cacggcgatg ggggactgaa cattccactc cgggtccgtg ggcggcgact
     1561 cgctcaccgc cagcaaccgg gaccgggccg gactggacca agacctcgcg gcggtccgct
     1621 ccggcgacac cttcgtcatc cccaactcga ccggctcgca cgctccttcc ctgacatcat
     1681 cagattgccc cggcaagcac gacgccacta ccgaggagta cttcaatgcc caccttgcgc
     1741 tggaccaccc ccaactctcc cgaaggccac gaatccgcgc tgatcatggc gtcgcgattc
     1801 gaggtccgga gccttaagga cgtgccgcgg ttcttcctca actcgctggc ggcgtggcgc
     1861 caggtccgca aagctccagg ctgcttcggc gcctcgctcg tcgcccggcc cgtcaagcgg
     1921 acgttccaga cactgtccgc atgggagagc cgtgagcagc tcatgacgtt cgttcagacg
     1981 gagccgcacc gctccatcat gaaggcgatg cgctccacga tgagcgattc cacgttcgtg
     2041 ttctgggacg cctccgtcgc ggatctcccg atcagctggg ccgaggccga acgacgactc
     2101 gacgaaatgg cgaccaagga agcccaggag cgctgaccag ctgatgcgtc ctgcccgcag
     2161 ccacgtccac tgaccgtccg gacaagatcg tccagccacg ccgttggcgg tctcgggcgc
     2221 ggccagctcc ggcaggcact gcgcatggac gagctgactc agctcgaggc ggtgtcatcg
     2281 ggctgaccga agtggcaaaa gccaccgcgg aggacgcggg acgcactccc gacctggccg
     2341 ggcgcggact gcgtgcccac aaccctgccc aaagccaact cgccggggca ctgcctgaca
     2401 gaagccggca gaacacgtcc aactgtctgc ggacgaggct gcgatagggt cagttgatca
     2461 ctcgtacaca tggggagctg cagtagtgac gaccgacgtg acacccgaac tggccgaggc
     2521 gatccagcgt ggctacgacc agcgcgaccg ggcgaacatg gcgccgacga tcgcgtactt
     2581 ccaggcgctg ctcgccgaac accccgacca cccagtcctt gtatacgagg tgggtggcgc
     2641 ctacgacacc gcgggcctgg aagagaccgc ccgcggctac tacgagcggg ccctcgccct
     2701 cggcctcgac ggtgacgccc tgcgccggtg cctgtgccag tacgccagca ccctgaggtg
     2761 gctgggcgag ctggacacgt cgctcgtggt gctcgaccgc gcccgcaggg agttccccga
     2821 ctccgactcc gtacgcgtct tccgcgccct gaccctcaac gatgcccagc ggccggacga
     2881 ggcggtggcc gagttgctca ccgtcgtcac cgggcacgcc gaggtcaccg acctcgggcg
     2941 gtgggcggtc gggctgagcg gcctcgccca gtggctcgcc gacggccgcc ccgaatagga
     3001 agcgtccccc tgcgcaaggc cggcgggatg ctgagcgggc gcgaagctgc cggtttcgag
     3061 gagtcagggc ccgccgcctg gcccgccccc tgccacaggg ccagcaggca cccatccgtc
     3121 tcgctgcctg accttgatgc cccgctgccg tccacctcac cgtccatcgg cgcccaaccg
     3181 aacggcaacc ggcggagcac agctcgccgc ctggggcgtt tcgtggccag cacccggctg
     3241 accgagcgct ggagagccgc acgccaagcc agcgcgccgc cgcccctgcc ccgccccggc
     3301 cgacttcacg caggagacac tcgacttggg ctgaccctac gacagcgagg ccggacagga
     3361 tccgaacggc ggcttcccac ctcgtccccg cgcgctgaag tggtgcccgc cctgccggat
     3421 gtcccggccg ggctcgcgag ggaggaactg gtggagacct tcgagacggg gcaaacggtc
     3481 gttcggcgtg acgtacaccg ctccgggcgg gtgtggagtg aacaggcgct acgggtcctc
     3541 gccgacacgg gcgaggcgct ggtgaccgcg tgcccgcccg ggactcaggc ccgctggccc
     3601 accccgggcc gggcccttcg ccgacgccga ccagtgggcg gcctggcgct ggaaccccgg
     3661 ctggccgccg ccatgtctgc cccagtgcga gggagccatt gagcacggag cacggatcac
     3721 tgacaccacc ccaaccggtg tgcgcgttgc accgcacgac gcaccgcccc cacctggaca
     3781 aaagggatcc acccggccag ggtcgtatcc gtgagcaccc ctcttggcgt cacgctgcgc
     3841 ccgtacaccc cggctgatca gaccgctgtt ctccacttga tcaacgccga ccgcctccct
     3901 ggccagccgc cgaccactcc cgcgatgctc catcaggcgc tggagggccg ctcgccagta
     3961 gatgcgcagt ggtgggccgc actggaccag cccaccaccg aggtggtcgt ggaggacacc
     4021 ggggccgtct tcggcgtggt gtcctacgcc gtccggccca aggacgacac gggggtgatc
     4081 ctgtggctgc attgcgggga ggccgcccgg accgccgacc tgctgatccg gcgcgcggtc
     4141 gccgcactgg cgccgcgccc ggtccaggcg ttccagatcg cctccgcgct gtctctgggg
     4201 ctggaggcgt tgccggtccg gaaccgtgcg gtcaccgatg aggcgttgcg gcgggcgggg
     4261 ttcaccggcg agcggctgtg gcggtacctg cgcgccgcac tgcccacccc gggcctgcct
     4321 cacgccgccc acgttcacat cggccgcgcc gacgacacgg gcaagaacac ccgacggctg
     4381 gagatccgca acggccccga cgtggtcgcg gaggctgtgg tgggcccgcc cgtccacggc
     4441 atcggcgtcc tgtggcggat cgaagtggcc ccatccgcac gcggccaagg gctggggcgc
     4501 gccctgttgg gctctgccct ggacgtgttg accgggctgg gcgccaccga ggtgatcctg
     4561 tacgtcgacg acgatgctcc tgccggagac gaccgagacc gcaccgcaac gaaccgcctc
     4621 tacgattcag caggattcat cgagatcgac caactccact cctacacgct cgcacgcact
     4681 gggcatccgc gttgaggtct ctccgcatgg catcccgaag agactggtat gcctcgtcgt
     4741 agcgcagccg gcccgtgatg tactcgtcgc tggcccggcc gcatccgtcg gcgaccacgt
     4801 cgcgcaggtc gcggagccgg cggaatgtgt catccgccgg cccgacgatg tagcgaggcg
     4861 cgcagatcga tacttcgtag cgcagggctg tgcatgcttc gaaggattcc cacacggcac
     4921 gcccgcgccg ctgcggatct gggtctggct cgcgcacagc aacgcgacag gtgtgccggg
     4981 tctgtgccag ggccgccagg taggagacgt agagggagcg gcggcccgct cctggccttc
     5041 ctggcgtcca ctgacgcgcg ctgaatcacc cggggacacc gtccccctca ccggcggcat
     5101 gcgctgacgc aacgcggtcc tcgccgccga cccgaaacgg ccggagccgt tgctcaaggt
     5161 cagcgagggg agaggaggca gaactcgttg ccttccggat cggccagaac cgtccaggag
     5221 atcgcggacc ggtcgatacc agggtcggtg gcgcccagag cgcgcagtcg ggcttcctct
     5281 gctcccaggt cgtcaccggg gtaggggcac acgtcgaggt ggacgcggtt ccacacgctc
     5341 ttggtatcgg gggtgcggag gaactccagg tagggcccga cgcccttggc ggaacgcatg
     5401 gtcgcatggt cgtcggtgac ctcgtgcagc gtccagtcca tcgtctcgcc ccagaaccgg
     5461 gccatccctc gtgggtcggt gcagtcgacc accaccgcgg cgatcggccc ggtgtcctgg
     5521 tagatcggac ggggctccag gacgcagaac tcgttgcctt ccgggtcggc catgaccgtc
     5581 caggggacgt caccctgacc cacgtcggcg agcgtcgcgc cgagatcctt caggcgcgcg
     5641 accaactccg cctgatgggc ggtcgaggtg gtggccagat caaggtgcac ccggttcttc
     5701 accgttttgg gttccgggcg ggcgacgatg tcgatgcaga cggccacggg gtcggggtag
     5761 acgaagccca cgggttcgag gttggtcacg ccaggtccct cgctgtcgac accccaaccg
     5821 agtgcctccg cccagaaccg gccgagcacg gagtcgtcct gggccttcat attaatctgt
     5881 acgagtcttg ttgccatgtc tcagatccta gaagatgccg cccgaccgcc gtgatccgac
     5941 atgtgctcga cccggtagtg accatggtcg cctctttctg tgtcgccgcg accagcctgc
     6001 aggagttcct cgaacggatc ggccaacggt tcgcgaacca gcccggatca tcggccgagg
     6061 cgcagaaccg gcatcccgtt gccttgaggc gatctcggtc gtcggatgac gtcatttctg
     6121 gtggacatcc ggagcacaca agatcgccgg ctgctgccca aacccttgac caatcgctgc
     6181 tacttcacgg gttctggctc agcttctgcg ctctgtcgct attttggggg tggttgggca
     6241 tcaattctgt gtgatgggtg gggtccgcat cgcggacgtt ctgctgccag gtgtcgaggt
     6301 tcggatcgat cgagtgacac tcacggagac ggaggtccgg ctcgccgtaa ggtctcaggc
     6361 cgcgtcggca gcatgtcccg actatggacg gcgatccgcg agggtgcact gctactaccc
     6421 gcggactctg gcggatcgtc cggtggcagg caagcgtgta cgacttgaac ttcaggcccg
     6481 ccgactcctg tgtgacaacg atcagtgtga ccgccgcact ttcaccgagc agataccggc
     6541 cctgacgcgt cggtacgcac gccgcacgga cgctctcacc gcccagctcg ccgacctggc
     6601 cctgttcctg ggcggcaggg caggagcacg cctgtccgaa cgcatgtcca tcggcacctg
     6661 caaggacacc ctgctccggt tcatccgcgc cctgccactc ccgtcctcgg cccatgtccc
     6721 gcttctcggt gtcgacgagt tcgccctgcg gcgcgggcgg acctacgcaa cgatcctcat
     6781 cgacatgtcc acccaccgcc cgatcgacgt tctcgctcgc gccgcgaaca ccttcgcatc
     6841 atggctgcgg aaccatcccg aagtgcggat catctgccgc gaccgtgccg attcattccg
     6901 tgacggagcc caggcgggcg ccccgcaggc ccagcaggtg gccgacgcct ggcacctcct
     6961 gcacaatctg gccgaagcag tcgaacgcgt tgtaggccga caccgtgccg acctgcgaga
     7021 acctctcacc tcccatcacg atcagactga agacagccgg cctcaggaga acccagacca
     7081 cacggaactg gacatccatg gacggccacg gcctctggtc acccgcaccc gtgaacgcca
     7141 ccagtaaatc cacgaacgca tcgagcgcgg tgacagcctt cgcgccatcg cacgacacgt
     7201 gaacggagcc ggccgtgcct gttacaggac agtgacaccg cgccgacaac gcattcgcgt
     7261 gacggaacat ctcttctggt gagaaccacg ccaatggcat ttgtcttgcc tttgtgtgac
     7321 aaccgacagc ttcactggag gggaccacca tgatcgtcac caagcggcac tccctgcgta
     7381 tcgccgtagt cagcgccatc gcggcagcct ccgtcgctct ggcaggcacc gccgcgatgg
     7441 ccgcgactcc ggcgacggcc agcacctccg tcgcgcagaa gtcactcgcc gccaaggcca
     7501 ccatcagtgc gaagccgtcg gtgggctccg tcaaggcgtg gcagctgttc cgtgtcaccg
     7561 gcacgacgac cggcctcaag gcgggcacca aggtgacctt gcagcagagg cagggcagca
     7621 agtgggtcat gctgcccgcc tccgtccccg tcgcgcgcaa cggcgcctac tcgctgggcg
     7681 tcaagctcgg cctcaagggc aagaacagcc tgcgcatcgt cagcgggaac acggcctccc
     7741 ccgtcttcaa cgtgacggtg cgctagtccc cggtgatcga cctcgactgt gccccggcgc
     7801 cggatgcgcg ccggggcaca gtcacgtgcg gcaggcgtgg agcgggtggt ctgcggctat
     7861 gggacgttcc aggcggagat gacgggctgc tcgtcctcga tggcatggca aacgctcctt
     7921 gatccggcaa ctagcggggg tagacctgga acgtcaccgc tgggacgccc ccgaagcgtg
     7981 gggcggccat gtcgagcatg ccctggagga aggactgggc gtagtccttc ggggactggt
     8041 cggagagcgc cgtgatgtac gcccggtgct ccgccagtga agccaccgcc cgctccgctc
     8101 ccgaaggcgt ggcctccacc gcgtgcgtgg cctgggggga cccggccaca gccacccacc
     8161 gcacgccgtc ccacggcgcg tccggcaggt cggggaagat ccagcggttg cccgcgtcgc
     8221 ccgccgcgtc gagcgtggcg cggccgacga ttcggtggtc gggggagttc caggccgtgc
     8281 cgccccaagt gtcgtggtgg ttgagcgtga tgagcagctc gggccggtgc ctgcgcaccg
     8341 ccgcggccag gtcgcggcgc agttcgaggc cgtcctggat gacgccgtca gggtgatcga
     8401 ggaattccac cgccgtgaca ccgaccacgg ccgcgctggc ccgctgttcg gcctcgcgga
     8461 tccgggccga ctcctttggc tcgaggccgt cgatcccggc ctcgccgcgg gtgaccagca
     8521 gataggtgat ctcgcgtccc gctgcggtcc actgggcgat cgccgcggcg gctccgtact
     8581 ccaggtcatc ggggtgggcg acgatggcca gtgcgcgctg ccagtcgtcg ggcatgggtg
     8641 tcagttggtc cgtcatttcc gccacgttag ggcctgtccg gtcgagttgg aaccgggatt
     8701 gtgccgcggt ggtgcggcga gccgcgatgt gcggagcccg acgtgagggc cggcagccgg
     8761 tagcggaaga gcggacgccg gtcgctgctc gaaacgagca gcatcgcagg cgttcggatt
     8821 cttcgatgga gcggagcctc ggcccatttc ctgatctcgt accgcagaac tgccacgccg
     8881 ttttgcgaag gcggtgatct caggtgcact gacgttcggc gcgctgtcgg atcagctcct
     8941 cgacggcggt gggcagggtg gtttcgaagt cgatgagttt cgcccaggtc ggggtgatga
     9001 cgatgcggac catgccgtcg tagagggagc ggacctcggc ctcccactcg gtgcgctgct
     9061 cgggtgtcat cgcgtagctg ccgttcatct ggagatactc ctccgggatg ccgtcgacga
     9121 cgtccagctc ggcccgcccg cgcaggagca ggatcttcgg tgggtggacc tcggtgtcga
     9181 tggtcagggc aacgatcggg ttcttgcgca gtgcgggcag tttcgcggcg ttcttcgtgg
     9241 tgcacaggac gatctgcgag ccgttccagg tgaacgcgat cgggatactg cgtggggtgc
     9301 cgtccgtggc gacgtaggcc agccgggtca ggtcgcgggc cagcagatcc tggctgatcg
     9361 ggcggttcag gatctcggtg atctgggtcg gctgcatggt gatcgctcct tcgtcgaggt
     9421 cgtggagcgg ccggttcgcg gcctctcgtg cccctgggac ggagccggcc gcacgttctc
     9481 gacatcccgc gcacgaattc tcctggaggc ggccgcgcag gagtacgccg tctacggtcg
     9541 gagcctgggg gaggtgtact ggcaatgcgt gccgctccgt cggttcagcg cgcgccgctg
     9601 gcaggcccag ggccacagcg atgtgggaac ggcgccgccg catcgccgag gacggcggtg
     9661 cccgcctgct cgtggacctg gccgaactgg cccgcccaca ggtcatgaca gataccgccg
     9721 ggatcacggc ggacctggcg gaccacggcc gtacgggcac gcccgacgct ggaagccggt
     9781 gtgcccggtg catgctgccc gatgcgctgt tgatggagga aggagcggac cgtcgggcat
     9841 gccgacggtc cgccaccgat cacatggtgg tggtggtcgg gttggtccac aggctttcgt
     9901 ggatgctgaa gcaggggggc cagaaggccc cttcctgttc ggcgtcgacc tcgacggtga
     9961 gttcctgcag agcgagaatc tggttcatac cggcgttcct tcactttcga gaggggacct
    10021 cagggtggat gggatgcccg tggtccaagg tgaacaactc gtcctcgggg ccgtgcagga
    10081 cacgttgcag tgccagaagc actcctgcgg cgccccaagt caggtcggcg gtgcatcgca
    10141 tgccgcccgc gccgaggtag cggacaccct ggccatgggg ctgggcgtgt ttcagcagtc
    10201 cggtggcgac ccgtacggcg gcttcacggt cggtcggccg gccggtcagt tcggcgtgct
    10261 cggcgagaaa gtaggtcagc ccggcaagtc ctgtggacca gcccggttcc atggcgcagg
    10321 tcttcctggc atcggcgacg agcagcggca gtgccgcgac gcagcggtcg tccggcgagg
    10381 tcgccacata gcgggtgagg accgtagcca cgcccgccga gccgacggac aggtagggca
    10441 tggcacgcct gatcacggca ttgtcggcga aggacaggcc tccgtcgggc aactggagcg
    10501 cgcggtcgag ttcttcgtgg atcaggtgac ggcctgctgt gaggtaggag gtccgacctg
    10561 ttgcgtcggc cagttggtgc aggaagaggg caaggccgga gcggccgtgg aacagccctc
    10621 tggcgtcgtg gtcgccgagg gtcggcacca ggtcggtggt gcgcacgatc gcgtctccgg
    10681 ctgccgcggc cagctccagg tgccggttgt cgcgtgtgcg ccggtgcagg gccagccagc
    10741 tcaggccgat tccggcccgg ccgtcggcca gtgtggtgga ggtgcgggtc aggggatggt
    10801 tctcggcggt ctgcaggagt tcggtcgcct cgtccaggcg gccgagctgc gccaggaccc
    10861 gggcgatgcc tgctgatccc gcgttcaggc cgggtggcag ttcatcgcgc agtgccaggg
    10921 agtcgaccag taatcgcttc tcgatctcct cagggatggg cacgcccgcc cggtgcaggg
    10981 cgtgtaccac ccccgaggtt ccgtaggcaa cgccgacggt gttggtgtgg aatgcctggg
    11041 gtgagggtgg gaagacccag tcggatcgac gggtgtcggc cgcatcgagc agtccgatgg
    11101 ctaccctcgc ggcgagatcg gcgaggcagc cttcgggatc ggcgtccacg tcggacgggt
    11161 cgggcaatgc cgcggaactg ccgccgtccg tacgctggaa ggcggtcgcg cgagcccaca
    11221 agtccgccgg cactgccgca gtggcagtca gatcacgtcg caacagcgcg agttgggacg
    11281 attgacgctc cgctgctcct tggaggggtg gagcgaagag ggacagcgtg agtgcggcca
    11341 tggcgtaccg gtcgtgcagg agcgggtccg tgtcggcgtc ggcgaggccg cgggggaggg
    11401 tgaacccggg ggtgcccatg gcggccgccg gctgagtcag cggtgtggcg gcctcgaaat
    11461 cgatgagtct ggcccgcagg tcggcggtga cgatgacgtt ggcgggactg aggtccccga
    11521 agcggtagcc ccgggagtga aggtgggaaa gggactcgtc caggctgcgc aggatttggc
    11581 ggcaggcctt gaagtagctc gcggagtcgc ggttgggcca ctcggccttg gtggtgggtg
    11641 agttccgtgc cacccaatgg tgcagcgaga tgccgtcgac gaactctgtg accaggaagt
    11701 cgtgttccca ctcggtgaag tggtccaggg gctgcgggca taccccgggg gccgccgcgt
    11761 ggacggcggt gaggacgtcg tattcgcggc gcagtctctg ccgcgcgctg acgccgtccc
    11821 aggtatagcc gttgtgggcg cgtgcttcct tgatgaagac agcgcgtccg gcgcggcggt
    11881 ccaccgcctg atatgcccct ccggcgttgc tgggctgcag taccttggcg atctcgtagt
    11941 ggcggatgac gatcggcccg gagtgcggtg cgggctcctg ggcgacgaag ggatcggtga
    12001 cgccgtcggg aaggatgaac acgggtcggc gttggtccgg cacgtcgcgt ccgaagccgt
    12061 cacggatgac cggttctctg ctgccgtcca ggcgtagccg gctgcggtgg ctgaacgcgc
    12121 cgtagcggta gtggacggtc cgagaatccc ggtagcggcg gtcggacagg atgtacgggc
    12181 cctcctcgcc ctccagcgcg gccgaaagga cggccaggag ccggtgggcc gtctcggtgt
    12241 cctgcgggta gagggcgcag aacttgccgg cctgtgcacg gtccgcgtgc ttgtggtgca
    12301 gtgccaggaa gaacttctgg gcgctgacgt gcttgaacgg cacccgctca gcgaagcagg
    12361 tatgtgctac agcgtcgagg acgtcctgtg tgcggtccag gcgcgcggac acatggatct
    12421 tccagccttg agcggcccgt cggagagagg ggtggctcca cgccgtccag atgtccttgc
    12481 cggtgctcag ccatccatcg gccacctgcg caggggcgag ccgctgcccg gtgtcgctga
    12541 tggttgccag cggggcgtag aactcctgac ccgcaagcgc cataccgatg gcgtcgagca
    12601 acggatcctc ctgagggtcg aacgaaggtg ggcagagtgg cgggtgggaa ggatctttgg
    12661 gaaccagtgg catgtcgttc agtggcatgt cgtcccaggc cgaagcaccc gggccggaag
    12721 tgtgacgtcg tgtgctcgat gccgggtcgc ggatcggacg gcaccaggca cgtcggctgc
    12781 acgacgtcgg gaaaggggtg tcgacagcgg gaggacagcc ctgcagcttt ctgcgatcac
    12841 cctcctcacc acccaccggc cctccgccgg caccgaggga ttgcggcgcg cgccgcaagc
    12901 cggaaacgca gacacgcgac gatcactgtg ccggagcatg cgccgacagc gcatccgtga
    12961 aagcccgtag ccccgcacgt agacggcggg ccggccggcc gaaggtcggc ccccgtatcc
    13021 cgcagggttg cgcgcggccg gagagaaagc cggccatcat ctgtccggaa gccgacttcg
    13081 agctctcgca gaaccaagcg tgcccgcata gccttccgct tcgccgccgc caaaccattg
    13141 gacgaactct ccgggagcgc cgtccatgca ccgaatcgcg ccctcgtggc cgtcagcgtc
    13201 aacgtcgaga tcggcgaccg ggtccccgga gacgctgggg gaaccgggtt gcaccggtac
    13261 ctgctgcggc ttcctgaccg tgaacgtgca gcggttcggg gagatcgtgc agtggtcgga
    13321 ccgggaggtt ccgtgggagt ctcacaccgc cgagccgccg caccctccgc cggagctcca
    13381 cttcgacgcg gttcagtacg acgccgaagt ggctcgcgct gagggccggc gtgtacggcc
    13441 cgcggtgatg atccacggcc gtccggacct gcggatcggg ctgaggaaag ccatcgacga
    13501 caggtcgcca ccgtggtccg tactctgcct ccgggcagtt ccttggaagt cgctcgcacg
    13561 gggtggatac cgcggcgggt gggggcgttg atgcgggggg acggccgaag gtcagcgcat
    13621 ggctgtgggg ctcgtgggta ggcaggggga ccaacgattg caccttggcc gccggcacgg
    13681 tgaaactgcg gcggcggacc tcgtgaggag tttcagcggc ggacccctgc gggtggaggg
    13741 tggcggggcc tactgtgccg tcatgaagac ttccggcaag aagaagcccc tttccgagga
    13801 tctgaaggtg ctggatgccg acttggccgt ggccgctgac atgatcgccg gcaatgcggc
    13861 caccagtctg cgcgacggcc ggtgggtgga tctggtcgtg gacttggtcg aggccaaccg
    13921 gcgtactcag atcagcctgc acgaagcggt cgagaaggcg ctcgcgcacg gtcagagctt
    13981 cgagtccctg gcagctggat cccatctgtc ggccgagtat ctgcaggagg cgtacgagca
    14041 gttcgatcgt gcggcggtgg cacgacctgg tcccgataag gacggccggg agccgtggcg
    14101 ggtcctgggt tgagggccgt accgtcgaaa ggcgtccgaa agccagccct cccgtggcgg
    14161 gggacgcccg tgtcgtacgg catgttcaga gggctaacag ttcgtccggc gtaggagcag
    14221 ggtgacgaat ccgagggtgc cccggtagcc gtggagccag gtgtggcggt gttcggccgc
    14281 tgccttgagg gcttctccgt tgtcggggtg ctcggggtgg tccagggccc actgggagag
    14341 gcttccggtc caggaccact cgtagtcgtc ccatacctgg agggtgctga cgcgtcgatc
    14401 cgttgacggt ccatggcggc atcctgcccc tgcctgccgc gtgggtctca cggtttttgg
    14461 caggtagtgg gggacgcgca ggggcgggaa gcggatcgtt caggctggtg gatgggggtg
    14521 gtgcgtgctg tcagcgtgtc agggagacgg cgaagggctg gaatccatgg cgtcgcacga
    14581 tgtgggggac cagcaggatg agggcttctg tggcgcgggc ggtagtgatg ccgccgaggt
    14641 tctcgatcca ttccggctgc cagccgaggt cgccgagcag ggctccgacg gtcttcttgg
    14701 cgtggtcgtc ctcgccggac aggtagaccg ttggcggtgt ggccagcgta tgtggcgacg
    14761 tcatgaccat gaagagcatg gtgttgaggg tcttgacgac ccgggtgtcg ggtagggcct
    14821 gctggaggtt ttcggccagg ctgctgccgg ggtagacgag gtctcccggc agtccgtcgg
    14881 cggcatcgtg ggtggcgttg gagacgtcga tgaggatttt gtcggcgagt tcggtgcgca
    14941 gttccgtcag tcgttccagc gcgctgtcgc ccggggtcgc gttgatcacg atgtcggcgg
    15001 cgcgcgcggt ggcgcgctgg tcggcgaacc ggatcgaggg gtccatgcct gcctccttgc
    15061 ccgctgctgc cgcgtcgggg gtgcggtggc cgaggatgac ggtgtgtccg gcggcggcga
    15121 gggcacgggc gaggttgctg ccgacgcgcc cggtgccgag aatgccgatg gtgctcatgg
    15181 gggactcctt gtggtgggag ggctgatcag gcgagcgggg cgaggaccgt gacggcggcg
    15241 gcgtgaaggc cgggggccgc ggccaggaaa tcagggctgg ccagattcca gggcgcgccg
    15301 ctgatgtcgg tgacggtgcc gccggcctcg atggccagaa gggcgccggc caccaggccg
    15361 gagcggacgt cggagaactg ccagaaggcg tccatccgtc cggcggcgag gtggatgagt
    15421 tgcaaggtgg cggggaccga gacccggacg accaggccgt tgatcagcat cgcggtgacg
    15481 gattcgccga tcttgcggaa ggtgtcggcg tcctcgccgg gcttggcctg gccggtgccg
    15541 accagggccg cgcccaggtc ggtcttggcc gacgcgcgca gcacggcgcc gttgaggtgg
    15601 gcgccccttc ccgcgatcgc ggtgtaggtg tcgccggtca gcggaaggtg gaccacggtc
    15661 aggaccggct ggttgtcgcg caccaaggtg gcggtgaccg cccagtcggg catgccgtgg
    15721 acgtggttga tgttgccttc ggcgggatcg acgatccacc actcgccgtc tggcagcgcc
    15781 ccgccggcca gttcgtcctc ggcccactgc gagcccggcc tggccaggag cagcggctcc
    15841 cgcatgactt tcaggaccgc gtcgtcgttg gcgtagatct ccttcacgat ctcgtcgaga
    15901 gccgttccgc gagcgtgcgt ggtgaagcgg tcgagcagtg tgtcgcctgc ggttcgaacg
    15961 atggaagtga ccgtggccaa cagggagttg tcgaggtcga aagacgtgtc gaaggacatg
    16021 gggtgctcct gaagaggaag tgaccgaagc ggcgatggcc gcggccctgg tgtctggtct
    16081 cgaccgtaga ccgaccactg attaacaacc agtgcatgtt ggtcagctat atatttactc
    16141 tcatgcactt ggacttgaac ctgctcacgg ccttggacgc actactggaa gagggcagcg
    16201 tgagcggcgc ggcggctcgc acccatgtca ccgccccggc gatgagccgc tcgctgggcc
    16261 gtctccgcaa ggtcaccggg gaccagatcc tggtccgctc cgggcacacc atggtcccca
    16321 ccacctacgc tctcgccgtc cgagcacagg tccacgacct cgtgcagcag gcgcacgagg
    16381 tgctgtcgcc ggaccgggag gtggatctga gcacgctcga gcgcgtgttc acggtgcgct
    16441 ggcacgacgc cctcgccgac gcctgcggcc cggccctgtt ggcaacggtg caccgccagg
    16501 ccccgggcat ccggctgcgt ttcgtcgccg agcccagtgc cgacaccccg gacctgcgcc
    16561 ggggcgatgt ggacctggag tccggcaccg gcacgcccgc ggcgcccgac gtccgccacc
    16621 ggcagatcgg gcaggaccgc cttgtcgtcg cggtacgccc aggtcacccc ttggccggag
    16681 caccgctgac cgtcgaacgc tacgttgcgg ccgagcatgt caccgtctcg cgtcgtggac
    16741 ggctgcgcga cccggtcgac gatgtcctgg ccagcctcgg aatggagcgt gtggtcgtcg
    16801 ctgcggcccc aacagcatca accgccctac gacttgtcca cggcactgac ctggtggtat
    16861 ccgtccccga ggccagtacc cgagcggcgc gacgacaact gggcctgctg gcgctgccgg
    16921 tccccatgca actgccgccg atcgggctgt acctggcctg gcaccggcgc catgacaacg
    16981 accgggccca cacctggctt cgcgaacagg cccgaacggt cctgcaagcc ctgttcgcgg
    17041 aaccgaccac accggaacgg caaccgaccc gatgagcggc gctcgcggca atacggaatc
    17101 caccggacac gcggtacgtg ccccccggcc acggctcccc tctacagcag acacggctga
    17161 gaggccgacg accgcctcgc cctgcaggcc ggtgccgaca cgaccggcac cgcaagatgt
    17221 tccttctcca gtaccacttc gcgatgttcc cctggaacgc gagaaccgga tagcaggaac
    17281 ccctgctgcg gccggcatac agccagtgca tgcaggtgcc cagccgtggc aggccggctt
    17341 catgttgatc cgaaagggcg atgccgcgca ggcgtcctga ggccgtccgt gcagaacggt
    17401 ggcggccacg atggcagtat ccggtgctga gggtccccgg tgtctccgcg cggactcgtg
    17461 cagtgatcct ccgggtcgaa gaccggcaga tgtggcccaa cgcggtcgcc caggcactct
    17521 cgtgtttcga gtgggcggcg acgcgctggt ggtggaccgg aatgcgggaa cgctgacggt
    17581 cgccgaggtc gccgcccctc cctggcttcg gtgccgaggg cgatcagcag gtgagacttg
    17641 ccggtgccgg tgccggtgcc ggtgccggag tcggagtcgg agtcgcggat gaggaagagc
    17701 cgcaggctct tcttggtcca ttcgcacttg gcgaggatac ggatccgcgt aggtcgcgat
    17761 caccgggtcg tatcgggtgt tgcggccaac ccgcattgcc gtccccgact gatagcccac
    17821 agtcagttcc tcgacctcgc tgagaggtgt tctgccagcg ggccccctgc gggtggaggg
    17881 tgaaggcgcc acattggcgg gagtctggag cgagttccca ctggggcctg ttcatgcatg
    17941 atgacgggat gaaccacagt aaccagcgct tccacgtcat cgtgctgtcg aacttcgcga
    18001 agggtttcga caagtacgcg ttcgcatacg gtaaggcggg gattccggag agtacctatc
    18061 ccgacaggtt ccacctgctc acccgtgcgg agttgggaat cggcatcgcc aaggcgcgac
    18121 gcttgctgga ccgtctggcc attcccggcg accgggtgct ggtgctggaa accacggtgg
    18181 accccgacaa gctggtgtcc aacgtgtcga ccggcctcgg catggaactg cacgaggatc
    18241 gcatccggtt gtcagaagtc cacgagctcg accaagtagg cgacgagttc actctgcgcc
    18301 cgacaaccgt cgaggatgcg atggcggcct ccctgcacct gcacggatcg gcacagcgtc
    18361 gctacgccga cacgcgaccg cgctcggttt cgcttctgcc ggtcgcctcc gcctgccaag
    18421 cccggtgctc gttctgcttc tcctcggctt cgatctccag cgaccaagcg ccggcacggg
    18481 tcccgtggga cgcggtcgcc cactggctgg agcgcgcccg tgcggcgggt gccgagcgtg
    18541 cagtgatcac cggcggcggg gagcccacgc tcataccgtt cgaacagcag ctgcgactgg
    18601 tgtccgcctg ctcggcggcc ttcccgaagg tcgtcctgat caccaacgcg cacaccctgg
    18661 cgaagggccg gcacgctgac cgggccggcc gcctcgcagc cctgagcgcc gcaggcctga
    18721 gcgtgctggc ggtctcccgg caccatcagg acgacgccgt cagcgagcgg ctgatgatgc
    18781 tgcgcacgcc ggtggcctct gtgatcgaca cctggcgcgt ggaacgtgac cgctggccgg
    18841 ggctgcggat gaggctgatc tgcgtgctcc agcacggcgg cgtcgccgac gcggccgacg
    18901 tcgccgacta cctttcgtgg gccgcggctc tcggtgtcga ggaggtctgc ttcaaagagc
    18961 tctacgtatc caccagcacc gagtcgctct acttcgaccg cgccgccaac gtctggagcc
    19021 gagagcacca ggtttcgctg tccatcgtta cccggttcgc cgagcggcac ggcctcgaac
    19081 tggagagccg cctgccctgg ggcgcgccgg tctatcacgg cagctgggac ggacggccga
    19141 tgcggatcgc cgcttacacc gaacccagcc tgctctggga acgcaccaac ggaatcgcac
    19201 gcagttggaa cgtcatggcc gacggacgct gctacgcctc cctggaagac cgggccagcg
    19261 agatcgtgcc ggaaggtgca acggcatgag gttcgacgag ttccaggaat tccggcagcg
    19321 gcaactcagt gcttcctcgt cgcttctgga cgccgccgat accaacgtgt accgggcgct
    19381 tgctccgatg cgaccggaac caccgaccga catgactacg gtgtaccggt gcgatctcgc
    19441 ccgtgcctgg ctgcggcgct tcgagctgcc ggaagagtgg tccggccacg ccatggtctg
    19501 tcgaggggtc cggcacgggc tcggcgtggt gttccattgg ctgcgtgccg tgcaagcgcg
    19561 gttgtggctg cccagcgacg tgtacccggt ttacttcgag ctggcccgcg ctgcgggcct
    19621 ggagcccgcg tcctacccga cgctaccggc gccggccctg ccgaggtcgc cggcggacga
    19681 ccggcccgaa tacctgctgc tcgccaaccc cagtaagccg ctcggccgat acctgtccga
    19741 tggcgagtgt gacgcggtga tttcgtggtt gctggtatca ccacgccgcc gcctgctgat
    19801 cgacagcgtc tacgacctgg gagccccgtt cgccgccggc acacggcgat tgctggacac
    19861 cggtcgtgcg gtcctgctgc attcggtcac caagggatgg ctgtggcccc gcacgttcgg
    19921 cgtggtcctg ctgggtccgg ggcaagtcga attggccgag gcgttccggg cggatccgcc
    19981 gacgtcggca cagctgaggc tcgccggccg tctgctgacc gagcacagcg acgtgccccg
    20041 gcaggtcgtc gacgaactgg ccgcacgggc tgagcggctg ttcgaacggt tgccggacga
    20101 agtgctcggg gcgattccca cggcgagccg gacgtgtccc ggcaactact tcttcccggt
    20161 ggaaatccca gcgcagacgc tccagcgcga gtgcggcgtg cttgccatgc cggtcagtgt
    20221 gttcggggag agcaggtggt ccggctccgt cctgaccagc cttgctgacg ctttcggccc
    20281 gacgccggcg gtggcacgat gagaccactg caggacctgg ccgtatacga cgatgcggac
    20341 ttctacgatc aggagttcgc cgcgcggacc cacgacatcc cgttcttcct cggccaagcg
    20401 gtccgggcgg gcggtccggt cctggaggtg gcctgcggaa ccgggcgcat caccctgccg
    20461 atcgcgcggg cgggtatcga ggtcacaggg cttgacatca tgccctcgat gctcgcgcgt
    20521 gcccgtcagc gggccgagga cgagcgactg ccagtcgagt ggctggaaca ggactgccga
    20581 gacatccgct ccgacaggcg cttcgccctg gtgttctcgg caaccaatgc gatgcagcac
    20641 ctgcacgacc tggattccgt ggtcgcgttc ctcacctcgg cgcgaaacgt gctgcgacca
    20701 ggagggaccc tgatcctgga tgtgttcaac cccgacatgg ccaagctgtg ccggctcccc
    20761 gagtcgccct accaccacaa gtcggtcgtg gaccgggacg gggcgaggct cgacgtgcga
    20821 gcggcgacca gctacgacgc cgccgcccaa gtgctgcgct tcacgctgga ctacctacgc
    20881 gacggcgtgt gcgtacgcac caagaaggtc agcatgcgct gcttctttcc cgaggaactc
    20941 tcggcgctct gccggctggc cggtctcgac gtcgcgcagc gctacggaga ctacgatcaa
    21001 tccccgttca cgagcacctc gccgaagcag ctcctgctct gccgctcccg aaccgccaac
    21061 ggccagatcg gcgatccgcc gtcggtaccg gtcatgcctc cgagctgagc cggcaccaca
    21121 ttccggtcaa catgcctggt cgggggccgc atgagcggtg atcctcgttg tcgtcgccgc
    21181 gtccgggtgc agggcgcgcg ggccgggtac ccctgttccc cgtcagcggt caccacggca
    21241 gggcgcaggc cccttccggc gagggcggtg cgagctcggt cggcgaggtg ggggtcgctc
    21301 tcgacggtga ccagaccgtc cgggcggact cgatgggcga ggagagcggt gctgtagccc
    21361 gagccggtgc cgatctccag caccgtgtcg tccggccccg agtccaggtg gtgctcgtcg
    21421 cgacgtccgg cgcaattccg tcggccgggg cccgggtcgg gcgaggagcc cctgtgtgtg
    21481 gcatggatgg gcgagcatgg ggtggtcagt cgcggggacg ctccggaggt ggtggccgtg
    21541 ctcaacgagg tcaatgcgtt ctcggcttgg ggaagttgtc cagcgcgagg ttcggcgggg
    21601 ctgctgtcgt gataccggcg cgcccgagct ggcgcatcca gttgctcgga tcgttcgccg
    21661 tgaccgtgga gggggtcgcg atcgaggccg gggcgtggcg gttgcggaag gcgaaggcgc
    21721 tggtggcgat gctggcgctg gcgccgggcc agcgctgtca tcgcgagcac gtcctggacg
    21781 agctgtggcc cgatctggag ccggcggccg cggcccgaaa tctgcaccag accctgtacg
    21841 tggcgcgccg cgcggtcgcc ggcggcgggc ccgcggaacc cggacggctg tcgatccggg
    21901 aggagcaggt cgtgctggac gtcgctggac cggtcgaggt cgacgtgttg cggttcgagg
    21961 tgtccgtgca ggaggcgtcg gcgggggacg atgtggcgat gttgcgcgcc gcggccgacc
    22021 tctatgccgg ggatctgttg cctgatctgt cggacgcgga ctggttgacg acgcggcggg
    22081 agcagttgcg gacggcgtcc cgtgagatct cggtgaggtt ggcgaccgtg ctggcgcgga
    22141 cggcaccgga ggaggcgctg ctcctcctga cacgggcgct ggatgccgat ccggtgcacg
    22201 agggggctgt ccgtgtgacg atgggggtgc tggcaggcct gggccgacga tccgaggcgc
    22261 tggcccggta cgagcgcttg gtcgatgacc tcctggacgc gttcgggacc gacccggatg
    22321 cgcagacggt ggcgctgttt cgcgaactgt tgacgggtgc gccggcggcg gagcgtcctc
    22381 gggcagccga tgtttcgacc cctagtgagg ttgtcggcca tctgccggcc ccgttgacca
    22441 gtttcgtcgg gcgcgagcgt gagatcgccg acgtggagag gctgacccgg caggcccggc
    22501 tgctcacgct gaccggggct ggtggcagcg gcaagacacg actcgccgtg gaagccgcgc
    22561 ggcgagtgcg ttcgaggtac cccgacgggg cgtggttcgt t
//
