LOCUS       NZ_CP048835            21101 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. So13.3 chromosome, complete genome.
ACCESSION   NZ_CP048835
VERSION     NZ_CP048835.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. So13.3
  ORGANISM  Streptomyces sp. So13.3
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K., Quezada-Solis,D., Khalil,Z.G., Capon,R.J.,
            Andreote,F.D. and Barrientos,L.
  TITLE     Genomic and Metabolomic Analysis of Antarctic Bacteria Revealed
            Culture and Elicitation Conditions for the Production of
            Antimicrobial Compounds
  JOURNAL   Biomolecules 10 (5), 673 (2020)
   PUBMED   32349314
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K., Lamilla,C., Abanto,M., Maruyama,F., Jorquera,M.A.,
            Santos,A., Martinez-Urtaza,J. and Barrientos,L.
  TITLE     Antarctic Streptomyces fildesensis So13.3 strain as a promising
            source for antimicrobials discovery
  JOURNAL   Sci Rep 9 (1), 7488 (2019)
   PUBMED   31097761
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K. and Barrientos,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2020) Centro de Excelencia en Investigacion
            Biotecnologica Aplicada al Medio Ambiente (CIBAMA), Universidad de
            La Frontera, Av. Francisco Salazar 01145, Temuco, La Araucania
            4811230, Chile
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-JAN-2020
            Assembly Method                   :: Unicycler v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 140.0x
            Sequencing Technology :: Illumina MiSeq; Illumina HiSeq; Oxford
            Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005860785.2-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 04:03:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,707
            CDSs (total)                      :: 8,616
            Genes (coding)                    :: 8,274
            CDSs (with protein)               :: 8,274
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 342
            CDSs (without protein)            :: 342
            Pseudo Genes (ambiguous residues) :: 0 of 342
            Pseudo Genes (frameshifted)       :: 109 of 342
            Pseudo Genes (incomplete)         :: 268 of 342
            Pseudo Genes (internal stop)      :: 24 of 342
            Pseudo Genes (multiple problems)  :: 52 of 342
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:45:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1813187
            Orig. end                         :: 1834288
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048835.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Laboratorio de Biologia
            Molecular Aplicada, Universidad de La Frontera, Avenida Alemania
            0458, Temuco, Chile.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21101
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21101
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21101
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11101](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11101
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1225..3159
                     /locus_tag="C8250_RS08350"
                     /old_locus_tag="C8250_008375"
     CDS             1225..3159
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031475.1"
                     /locus_tag="C8250_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008375"
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_138353937.1"
                     /transl_table=11
                     /translation="MTAAAAAAALLPVLSTATSANAAQPATSSLQRAFSDAAQRYQVPA
                     SVLLGVSYMESRWDTHQGLPSVTAGYGPMHLTDARTALTDFPQKGDGGDDSRGDDSRPL
                     TGTGQAVPDADLSKLPATLTTLERAAGLTGLPAQDLRKDPAANVAGGAALIAAAQKSLG
                     QPLSADPADWYGAVARFSGADDSATAGAFADDVYDVLRQGESRTTDAGQNVTLAAAPGI
                     APATAQAAALGLKHVNDSGTECPRGVGCEWLPAPYQETTPGDYGNHDLADRPASQKIDT
                     IVIHDTEGSWDTALKLVQDPTYLAWHYTVRSADGHIDQHLRTKDVGWHAGNWYTNAKSI
                     GIEHEGFLIDPGTWYTESMYRTSARLVAYLAKKYDIPLNRQHILGHDTVPGPTGAYIGG
                     MHTDPGPYWDWAHYFQLMGAPLHATAGPGGGLVTIRPDYDENRPLYTGCVTAGDTCPAR
                     GSEAVRLHTAPSEDAPLVKDIGLHPTGDSTTGVNDVGARASTGQQYAVAERQGDWTAVW
                     YLGQKAWFHNPRSQPTAVNAWGWTATPKAGLADIPVYGRAYPEAAAFPAGVPVQAIVPM
                     PYKLLAGQEYAIGNRVQGEYYYSTTFDTASHQVVRGKQVYYEIQFGHRVEYVRAEDVTV
                     LPSQVGAPR"
     gene            complement(3254..3754)
                     /locus_tag="C8250_RS08355"
                     /old_locus_tag="C8250_008380"
     CDS             complement(3254..3754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="C8250_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008380"
                     /product="hypothetical protein"
                     /protein_id="WP_138353938.1"
                     /transl_table=11
                     /translation="MSFLRRRTAATPTGPDFDVLAMDPGDWPGILGAGLLPGPDGSCQG
                     IFLRYDLFGGRGPAMLIGNLPEGSPARELEDGQVPFEVAQLMVALGNEEPVEVVSTEDT
                     PAMHGDGLLIVRRIKVSEARIACAQFDRSDGVQVTIATWDRPITDDLYQLLKPLPAEMF
                     QQG"
     gene            complement(3832..6753)
                     /locus_tag="C8250_RS08360"
                     /old_locus_tag="C8250_008385"
     CDS             complement(3832..6753)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433330.1"
                     /locus_tag="C8250_RS08360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008385"
                     /product="AAA family ATPase"
                     /protein_id="WP_138353939.1"
                     /transl_table=11
                     /translation="MPEHRARSGRPLLEREPELAAVDEALRQLTGLRADGGESRERPRG
                     GLLAFSGTAGLGKTTLLAETRRRAADQGCTVLSARGGDQEQRVAFHVARQLLQPQLAGS
                     GESELRSSLGSWYGIVGPALGLCAAGDGAAPDPQGLRDGLDWVVTHLAQRRAPVVLVLD
                     DAHWADPESLGWLAAFAPRAAELSMLIVVAYRPEELPEHAGSFRGLPGSTGHRPLDLEP
                     LTADAIRDLVRASVGEHADDAFCRECWSVTAGNPFEAVELTAKVRDRGLRPDRTSAHLL
                     RELAAAVKGSGLTTRLERLGVPAVRLAWAAAVLGTEISPELAADIAGIGAAEAAEAADT
                     LRGARVLTGGATLEFVHPLIATAVYRAIPDAARVALHGRAAWSVVDAGLGASAAARHLL
                     ETHPEGDSWVVGQLRDAARETLRAGAPEAARSYLGRALREPPSPGERAAVLYELGCASL
                     LLEPATTVNHLRAALEEPAGDPALREGILFHLSQALAHSDRLDEAADTVGHAARTATDP
                     RVRLRMQAEQFMWDAFRADEPGSPARSRRLARLADRLTGRDLTERYIIGLRAWDAVLRG
                     EPSGTALRHAGRALDGGLHWAEADCGFEVPVLVALVHMYADRPGRAEELFADGIAEFER
                     QGWRGAHLSFGYLLLGYVRFRRGRLAEAEDFARAGLRLAERVGRGTPVQWYSVAVLIEV
                     LLARGRVAEATELAADHDFHAPFPAAVTFPDAQGVYGELLLARGMAKEAAVELAAVGRR
                     LNQRGMRNPAWCPWQPHLALAEASTAPDRARATAMEAVARARQFGAASTIGHTLRIAAE
                     VSGGAERMKLLEESVDSLERSPAGHQLACSLVAHGTALRRAGRPAEAAEQLYRGLEGAL
                     QCGADELASRARGELTSAGLRPLRLPATGTATLTEQEHAAAARAATGATPAAIAAELST
                     GEVTVGRLLSAVYRKLGTDPGGLPGAYRTDPPGGPSGAVAGEE"
     gene            complement(6898..9819)
                     /locus_tag="C8250_RS08365"
                     /old_locus_tag="C8250_008390"
     CDS             complement(6898..9819)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069078.1"
                     /locus_tag="C8250_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008390"
                     /product="AAA family ATPase"
                     /protein_id="WP_138353940.1"
                     /transl_table=11
                     /translation="MPDAVEQLGRVNRLVLERESELVALDGALNDLCGTRSGTKHGGLL
                     AFAGPAGGGKTALLAEVRRRAAARGCTVLSARGGEQEQGMAFHVVRQLVQPVLAAASEE
                     EHRRILGSWYDIVAPAVGLVASAGDGAPDPTGVRDGLDWVVTRFAVQQAPVVLILDDAH
                     WADAESLAWLTTFAPRAEELPMLVIVAYRPDELPANAMAFRKLAGRHGSRPFDLVALTP
                     GAVRRIVRDAVGESAEEAFCREAWAVTGGNPFEVTELTAKICDRELKGQREEIPELREL
                     ASAVKGSGLIERIEKLGPSAVRFAWAAAVLGTSIAPPLAAGVAALGREEAADAFERLRA
                     ARILTVGTNDSSTLEFVHPLIATAVYRAIPSALRVGMHGEAASAVTEAGLGAATAARHL
                     LELHPEGDEWVVQQLRGAAREYLRAGAPEAAQRCLARALREPPPYGERAAVLFELGCSS
                     LLNEPANTVNHLRAALEEPELEPELREAITYRLAQALGHTGRMAEAARTVEAEAGRANN
                     TRTRLRMQAEQFMWNAFRADEQDSPARSRRLARLADHLTGRGPAERYILGLRAWDAMVR
                     GEPAPVAVRYAEEALGDGLSWTDENWGFEVPVLVALTFMYCDQPGRAEDLFTKGIAELE
                     RKGWRGAHLSFGFTLLGYIRYRRGRLAEAEDLVHAGLGIADRVGPGVPAQWFAIGILIE
                     ILLARGRTHEAQELADTYNYGEVIPNAVVYPDSQTVFSELLLAQGMRGDAERHLTVVGQ
                     RLEARGMRNPGWCPWQLHLAQAVALVEPERAADTIREAVQRARQFGTASAIGQALHASA
                     EVTGGADGLRLLAEAVSHLERSPSAFELARAQVAYGAALRRAGLPQDAADRLHAGLEGA
                     LHCNSDALAGRARDELAAAGMRPLQLRSTGTDTLTGPERTVAEQVAGGRSTAEVAKEMG
                     AAEREVTRMLSAVYRKVGTDHAGLAKALEQTSDNGFQHSALGR"
     misc_feature    complement(9888..9904)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     misc_feature    complement(9889..9904)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.77"
                     /tool="antismash"
     gene            10001..11101
                     /locus_tag="C8250_RS08370"
                     /old_locus_tag="C8250_008395"
     CDS             10001..11101
                     /EC_number="4.2.3.157"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041624.1"
                     /locus_tag="C8250_RS08370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008395"
                     /product="isoafricanol synthase"
                     /protein_id="WP_138353941.1"
                     /sec_met_domain="T1TS (E-value: 5.1e-82, bitscore: 275.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTTAPSGPIQRDILAERTTLLSIPFPGRSSPHTDRARRHTLKW
                     LRDLAILRFDRDVEEYDALRLERLMAFFYPRATGPDLDLAADFNAWFFIFDDQFDGPLG
                     RRPDDVEREVDTLVSILYEPPSPVRGAANPSDNPLADGFRDIWVRSAAGTPTVWQHRFR
                     DHWRDYLRAYHWEALNRTRRPAMTLETFLRGRRDSIGVQPCLDFAERCGGYTLPDMLHS
                     GPLAEMREITSDVVIFVNDIMSVDKELAAGDVNNSVILLLDSSDHTLEGAVELIARAAN
                     ARVQRFQMLAARLPAVLDEYNAAPALRTQVEDYVRAMRHVMRGNLDWSLETARYRASGV
                     AAVSGGRQRPWSDLFGADRARPGGLG"
     gene            complement(11196..13139)
                     /locus_tag="C8250_RS08375"
                     /old_locus_tag="C8250_008400"
     CDS             complement(11196..13139)
                     /GO_function="GO:0004629 - phospholipase C activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141517.1"
                     /locus_tag="C8250_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008400"
                     /product="phospholipase C, phosphocholine-specific"
                     /protein_id="WP_138353942.1"
                     /transl_table=11
                     /translation="MTPLSRRGFLGAAGAAAAFGTLPASIQQAMAATSAAGTLDDVEHV
                     VIFMQENRSFDHYFGTLKGVRGYGDRSRLRFPNGQDVLRQTANGPSGGSLVLPWHLNTA
                     TTDAQRVRDLDHGWSGTHSAWNSGKYNNWVPAKSAWSMGYYQRADIPFQFALAESFTLC
                     DQYFCSVQGPTNPNRLYQWTATVDPAGRNGGPVTDNSEKGYSWTTYAERLQSAGISWRV
                     YQQQDNYDDNPLAWFKNFKSAATTSPLYVNGMQRRSADAFNQDVKNGTLPAVSWVVAPA
                     NQSEHPDYPPAYGANYTSKYVLESLAANPAVWAKTVVFLNFDENDGFFDHVAPPVPPAG
                     TADEFIGGVPIGLGPRVPMIVISPWSRGGYVNSEVADHTSPLRFLENWTGVKETNISAW
                     RRTVCGDLMSAFDFSTKNTTFPSLPDTAALVAACDAQNSLPDAAPPSAQVAPVQESGTR
                     PARRIGYGFDTTSWTETSTGRIWIKVVNTGTLGAGFAMYTVNHRTYDNWRYTVPVGGSV
                     QDYFSAQTYGGGLYDIDAHGPDGYLRGFKGDVRTWSNAAKGHPEAAVAIARATPRNLAL
                     TLTNGGGAAVVFTVGGNAAGDGSGGSTATVAAGGTQQVALTSAADGGYDYTVTANAGDG
                     FERRFAGRTYPA"
     gene            13490..14188
                     /locus_tag="C8250_RS08380"
                     /old_locus_tag="C8250_008405"
     CDS             13490..14188
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836382.1"
                     /locus_tag="C8250_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008405"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_244809025.1"
                     /transl_table=11
                     /translation="MAVNRPDPVPAVLESQSRLRALLGGLTDADVRAPSALPGWTRGHL
                     LSHVEGVGFALARQARYALKDELIDPYDGGRPARDAAIEAGHGRSAAELRAAVTAALDE
                     AEQAWTAVGPRDLERPVRYRDATLSAAALAWWRELEIHTADAAIGYRTAQWSRPFCAHV
                     LDFLAPRVPDAVRLTLAASDGPEALVLGDGEPVTVGGALTDLTAWLAGREPLGPLDSGV
                     APLPELGPWP"
     gene            complement(14293..14532)
                     /locus_tag="C8250_RS08385"
                     /old_locus_tag="C8250_008410"
     CDS             complement(14293..14532)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141520.1"
                     /locus_tag="C8250_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008410"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_138353944.1"
                     /transl_table=11
                     /translation="MAESTIGQPLTNGKKPQLDLASADWQSSSQGTGDVQIAFIEGYIA
                     MRDGRSPDGPSLIFTPAEWRAFVLGARDGEFDLT"
     gene            complement(14631..15797)
                     /locus_tag="C8250_RS08390"
                     /old_locus_tag="C8250_008415"
     CDS             complement(14631..15797)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057880.1"
                     /locus_tag="C8250_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008415"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_138353945.1"
                     /transl_table=11
                     /translation="MSKAPVAVVGIGQTKHVAARHDVSIAGLLREAALRALADAELTFA
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVASNLVAAR
                     VHRTVLTVAFEKQSESNAMWGLSLPIPFQQPLLAGAGGFFAPHVRAYMRRTGAPDHIGS
                     LVAFKDRRNALKNPYAHLHEKDITLEKVRAAPMLWDPIRYSETCPSSDGAVAMVLTDTE
                     GAARTPRPPAWLHGGAMRSEPTMFAGKDYVSPQAGKDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFAAEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGQAGEHQVEGARRALGHAYGGGAQFFSMWLVGADRPTT"
     gene            complement(15794..16840)
                     /locus_tag="C8250_RS08395"
                     /old_locus_tag="C8250_008420"
     CDS             complement(15794..16840)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890861.1"
                     /locus_tag="C8250_RS08395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008420"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_138353946.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQSRHARSTAEVSEVELLMPVLHEAFDQVELKASDI
                     GFTCSGSSDYLAGRAFSFTMALDGVGAWPPISESHVEMDGAWALYEAWVKILTGEADTA
                     LVYSYGKSSPGDVREVLTRQLDPYYVAPLWPDPVALAALQARALIDAGHTSEPELAGVA
                     ARSRASARDNPYAQLTSVRDGGEYVVQPLRRQDCPPVGDGAAAIVLAAGDTARRLCARP
                     AWIRGLDHRIEAHSLGVRDLTDSPSTRLAAERAGLFDAPVDTAELHAPFTSQEVVLRRA
                     LRLGDEVDVNPSGGPLAANPIMAAGLIRLGEAAARIHRGDSDRAVAHATSGPCLQQNLV
                     AVLEGDVK"
     gene            complement(16841..17791)
                     /locus_tag="C8250_RS08400"
                     /old_locus_tag="C8250_008425"
     CDS             complement(16841..17791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606694.1"
                     /locus_tag="C8250_RS08400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008425"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_138353947.1"
                     /transl_table=11
                     /translation="MTEVLSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTGDDRV
                     LVPPVEYDPVTSAELRELVEVGATGTVTTWAWNPDPGRNQPLSTPFAWVLVRLDGADTA
                     MLHALDAAGPDAVSTGMRVRIRWADERVGAITDIACFEPDDGTGPPERAATAHHGEFTD
                     PVTGIVAPARLDYVYSPGRAQTRYLAALADRKMIGERCPSCRKVYIPPRGACPTCGVAT
                     EEQVEVGPGGTITTFCIVNIKARGLDIEVPYVYAHIALDGADLALHGRIGGLPYDQVRM
                     GMRVEPVWSDDGGFPDHYRPTGEPDAGYDTYKEMV"
     gene            complement(17821..18627)
                     /locus_tag="C8250_RS08405"
                     /old_locus_tag="C8250_008430"
     CDS             complement(17821..18627)
                     /NRPS_PKS="Domain: ECH (12-260). E-value: 5.9e-52. Score:
                     168.3. Matches aSDomain:
                     nrpspksdomains_C8250_RS08405_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090683.1"
                     /locus_tag="C8250_RS08405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008430"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_138353948.1"
                     /transl_table=11
                     /translation="MGGTEHLTVERVGATLVLTLNRPEAKNALSLPMLVGLYDGWLAAD
                     ADDSIRSIVLTGAGGTFCAGMDLKALASDDGAMAGQEYRDRMKEDPDLHWKAMLRHHRP
                     RKPVIAAVEGYCVAGGTEILQGTDIRVAGESATLGLFEVRRALFPIGGSTVRLPRQIPR
                     THALEMLLTGRPYSAAEAKDIGLIGHVVPDGTALKRALEIAEQINANGPLAVEAVKASV
                     YDTAEMTETEGLKHELERGWPIFATADAKEGPRAFAEKRPAVFKRA"
     aSDomain        complement(17848..18591)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8250_RS08405_ECH.1"
                     /evalue="5.90E-52"
                     /label="C8250_RS08405_ECH.1"
                     /locus_tag="C8250_RS08405"
                     /protein_end="260"
                     /protein_start="12"
                     /score="168.3"
                     /tool="antismash"
                     /translation="GATLVLTLNRPEAKNALSLPMLVGLYDGWLAADADDSIRSIVLTG
                     AGGTFCAGMDLKALASDDGAMAGQEYRDRMKEDPDLHWKAMLRHHRPRKPVIAAVEGYC
                     VAGGTEILQGTDIRVAGESATLGLFEVRRALFPIGGSTVRLPRQIPRTHALEMLLTGRP
                     YSAAEAKDIGLIGHVVPDGTALKRALEIAEQINANGPLAVEAVKASVYDTAEMTETEGL
                     KHELERGWPIFATADAKEGPRAFAEK"
     misc_feature    18696..18711
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    complement(18701..18715)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.2"
                     /tool="antismash"
     gene            18809..20443
                     /locus_tag="C8250_RS08410"
                     /old_locus_tag="C8250_008435"
     CDS             18809..20443
                     /NRPS_PKS="Domain: AMP-binding (8-440). E-value: 1.8e-71.
                     Score: 232.8. Matches aSDomain:
                     nrpspksdomains_C8250_RS08410_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530284.1"
                     /locus_tag="C8250_RS08410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008435"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_138353949.1"
                     /sec_met_domain="AMP-binding (E-value: 4.6e-75, bitscore:
                     251.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALVYIDHPGSGAERRLTYAQLDAAA
                     NRIAHHLIGSGILPGDHVGLHLYNGIEYLQTALACVKARAVPVNVNYRYVEEELVYLYR
                     DADLTALVFDAEFTGRVAAALPHTEKLRHLVRVGVPAGDEREPAIAPVAFTDAEAAGSP
                     DRGFPPRSADDQFIIYTGGTTGMPKGVMWRQEDLFFSGMGGGAPTGEPVKRPEELAERV
                     AAGGEGLVFFPTPPLMHGTSTLTAFIGFNFGQKVVIHRKYVPDEVLRTIEKEKVSSVSL
                     VGDAMLRPLADALAGPLAGTDCSSLFTISSSGAIMSETVRAQFQALVPTVMILNNFGSS
                     ESGFNGTATDDSSPANGFRLRVNSHIAVVDLATLEPVTVGEPGRIALRGHVPLGYYNDP
                     EKTAETFFQRDGERWVLLGDMATVDEDGVVTVLGRGSQCINTGGEKVYPEEVEEALKAH
                     PDVYDALVAGVPDEKWGNHVAAVVQPRDGADPLTLDDIQAHCRTRLAGYKIPRSLVLMD
                     SIQRSPSGKADYRWARSVATDAAEAGR"
     aSDomain        18833..20128
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8250_RS08410_AMP-binding.1"
                     /evalue="1.80E-71"
                     /label="C8250_RS08410_AMP-binding.1"
                     /locus_tag="C8250_RS08410"
                     /protein_end="440"
                     /protein_start="8"
                     /score="232.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALVYIDHPGSGAERRLTYAQLDAAANRIAHHLI
                     GSGILPGDHVGLHLYNGIEYLQTALACVKARAVPVNVNYRYVEEELVYLYRDADLTALV
                     FDAEFTGRVAAALPHTEKLRHLVRVGVPAGDEREPAIAPVAFTDAEAAGSPDRGFPPRS
                     ADDQFIIYTGGTTGMPKGVMWRQEDLFFSGMGGGAPTGEPVKRPEELAERVAAGGEGLV
                     FFPTPPLMHGTSTLTAFIGFNFGQKVVIHRKYVPDEVLRTIEKEKVSSVSLVGDAMLRP
                     LADALAGPLAGTDCSSLFTISSSGAIMSETVRAQFQALVPTVMILNNFGSSESGFNGTA
                     TDDSSPANGFRLRVNSHIAVVDLATLEPVTVGEPGRIALRGHVPLGYYNDPEKTAETFF
                     QRDGERWVLLGDMATVDEDGVVTVLGRGSQCIN"
     CDS_motif       19334..19384
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C8250_RS08410_0001"
                     /evalue="3.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="C8250_RS08410"
                     /protein_end="192"
                     /protein_start="175"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     CDS_motif       19943..20026
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C8250_RS08410_0002"
                     /evalue="3.10E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="C8250_RS08410"
                     /protein_end="406"
                     /protein_start="378"
                     /score="19.6"
                     /tool="antismash"
                     /translation="VGEPGRIALRGHVPLGYYNDPEKTAETF"
     gene            20536..20880
                     /locus_tag="C8250_RS08415"
                     /old_locus_tag="C8250_008440"
     CDS             20536..20880
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677096.1"
                     /locus_tag="C8250_RS08415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_008440"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_138353950.1"
                     /transl_table=11
                     /translation="MSADSTSFQRPEPPYYAVIITTLPSGEDPEGYADANRRMGPLSAK
                     WPGYLGRESESGPDGRDLLVVYYSDAESIASWKADPEHLEVQRLGRERWYASYSVEVAR
                     VERAYGFRRD"
     misc_feature    complement(20979..20992)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.51"
                     /tool="antismash"
ORIGIN
        1 gcccccaggg cgctcagctg cggacggcca tcgccgcggt tcagcggata tgccccgagt
       61 tcaaccctgc tcagatgctg cgccgcagcg ggcgcaccgc actgctcgtc ggtacgtcgg
      121 gacgcagtcc cgcggtcgcc aagtgtctgc tggaccagtc cccagcgtgg gtcgagcggt
      181 tccagcacga gatagcggct taccgggcgt tcgtccgcca ccggccgcca gcccgggtcc
      241 cacggctgat cgccgcggat ccggagagct gtgtgctggt cctggagcga atgcccggac
      301 gggtcgtgtc ggtacagcgc catccgaccg agaccccgcc ccggtccgat gtccgtgcgg
      361 ccatcggcgc gttcggccgg atcaacctgt ggcggccgcc ggccggtgtg ttcgacgcgc
      421 cgatcgacta cccggcacgt atctcgcgct accacgagct ggggctgctc accgaccggg
      481 acatgggtga cctgcagaag ctgttgcacg gactcgccca tgtgcagggg cagttctgtc
      541 acggcgacgc cctgctctcc aatgtgctgc tgtccccggc cggcccggtg ctggtcgact
      601 gggagcacgc cggctggtac ctgccggggt acgacctggc ggtgctgtgg tcggcgctcg
      661 gcaacgaccc ggtggcgcgc cgccagatca gccagctcgc ccagaaccag ggtcccgcct
      721 cccgggacgc cttcctggtc aacctgatgc tcgtcctgac ccgcgagatc cgtacctacg
      781 agaccgccgt gcagcgcacc atgcgcagcg ccaccccgcc cgcgcagacc gtgcccggag
      841 cgggcgagga gcagcggctg ctgctgcgcc ggctgcacga cgactgcggt ctggcccggc
      901 gggcggtgcg tgccgccgtc ggcacgcgct gagccccgcg cggacccgtc ccgccccccg
      961 gatcacgggg gttttcacca cccgccggca cccgcgtcac cggttcagac cactgacgcg
     1021 gggcaggcca gcacgcccgt gccggggaaa ctcccggcac gggcgtttga cgtgcgcaaa
     1081 cagtgcccga ttggggcctg ttgacggatc gtccgggagc cgatacctct gtggagccgt
     1141 tcgccccagt accgcttcaa ggaggccgca ttgcgagagt ccgccgcccg atcagcgaga
     1201 caccgacgga gcacactgcg tacggtgacc gcggcggccg ctgccgcggc actgctgccc
     1261 gtgctctcca cggccacatc cgcgaacgcc gcccagcccg ccacctcgtc gctgcagcgg
     1321 gcgttcagcg acgcggccca gcgctaccag gtgccggcga gcgtcctgct cggcgtgtcg
     1381 tacatggaat cgcgctggga cacccatcag gggctgccca gcgtcaccgc gggctacggc
     1441 ccgatgcacc tcacggacgc ccgtacggcg ctcaccgact tcccccagaa gggtgacggc
     1501 ggtgacgact cgcgcggtga cgactcccgg ccgctgaccg gcaccgggca ggccgttccc
     1561 gacgccgacc tgtcgaagct gcccgccacc ctcaccacgc tggagcgggc cgcgggactg
     1621 accggcctgc cggcccagga cctgcgcaag gacccggcgg ccaatgtcgc cggcggcgcg
     1681 gccctgatcg ccgccgccca gaagtccctg gggcagccgc tgagcgccga ccccgcggac
     1741 tggtacggcg ccgtcgcgcg cttctcgggc gccgacgact cggcgaccgc cggcgccttc
     1801 gccgacgacg tctacgacgt gctgcggcag ggcgagtccc gcacgaccga cgccgggcag
     1861 aacgtcaccc tggcggcggc tccggggatc gccccggcca ccgcgcaggc ggcggcgctg
     1921 ggcctgaagc acgtcaacga cagcgggacg gagtgcccgc gcggggtggg ctgcgagtgg
     1981 ctgcccgcgc cctaccagga gacgactccc ggggactacg gcaaccacga cctcgccgac
     2041 cggcccgcca gccagaagat cgacaccatc gtcatccatg acaccgaggg cagctgggac
     2101 accgcgctga agctggtgca ggacccgacg tatctggcct ggcactacac ggtccgctcg
     2161 gcggacggcc acatcgacca gcatctgagg accaaggacg tcggctggca cgcgggcaac
     2221 tggtacacca acgccaagtc gatcggcatc gagcacgagg gcttcctcat cgacccgggc
     2281 acctggtaca cggagtcgat gtaccggacg tccgcgcggc tggtggcgta cctggcgaag
     2341 aagtacgaca tcccgctgaa ccgccagcac atcctcggcc acgacaccgt gccgggaccg
     2401 accggtgcgt acatcggcgg gatgcacacc gaccccgggc cgtactggga ctgggcgcac
     2461 tacttccagc tgatgggcgc tccgctgcac gccacggcgg gtccgggcgg cggcctggtc
     2521 accatccgac cggactacga cgagaaccgg ccgctgtaca ccggctgcgt cacggcgggc
     2581 gacacctgcc cggcccgcgg ctccgaggcg gtgcggctgc acacggcgcc gagcgaggac
     2641 gcgccgctgg tgaaggacat cggtctgcac ccgacgggtg actccacgac gggcgtcaac
     2701 gacgtcgggg cgcgtgcctc caccggtcag cagtacgcgg tcgccgagcg ccagggcgac
     2761 tggacggcgg tgtggtacct cggccagaag gcctggttcc acaacccgcg gtcgcagccg
     2821 accgccgtca acgcctgggg ctggaccgcc accccgaagg cgggcctggc cgacatcccg
     2881 gtctacgggc gcgcctatcc cgaggcggcg gcgttccctg cgggtgttcc cgtgcaggcg
     2941 atcgtgccga tgccgtacaa gctcctggcg ggccaggagt acgcgatcgg caaccgggtc
     3001 cagggtgagt actactactc gacgaccttc gacaccgcct cgcaccaggt cgtgcgcggc
     3061 aagcaggtct actacgagat ccagttcggc catcgggtgg agtacgtcag ggccgaggac
     3121 gtcaccgtcc tgccgtccca ggtgggcgct ccgcgctgag ccgttctccc acgggcggat
     3181 gttcggccgt gggacgtgac aggggcgccg ccggatcccg gcggcgcccc tgtcacgtgc
     3241 ggtgtgcgtc ccgtcagccc tgctggaaca tctccgcggg cagcggcttc agcagttggt
     3301 acaggtcgtc ggtgatgggg cggtcccagg tggcgatggt gacctggacg ccgtcgctgc
     3361 ggtcgaactg ggcgcaggcg atccgtgctt ccgagacctt tatccgccgg acgatgagca
     3421 ggccgtcgcc gtgcatcgcg ggggtgtcct cggtgctgac cacttccacc ggctcctcgt
     3481 tgccgagggc caccatcagc tgggccacct cgaagggcac ctggccgtcc tccagctcac
     3541 gcgccgggga gccctcgggg agattgccga tcagcatggc gggaccgcgc ccgccgaaga
     3601 ggtcgtagcg caggaagatg ccctggcagc tgccgtcggg accgggcagc agcccagcgc
     3661 cgagaatgcc cggccagtcc cccgggtcca tggccaggac atcgaagtcc ggcccggtgg
     3721 gcgtggctgc ggtgcggcgg cggaggaacg acatacggcc atcgtacgtg gcccgcggcc
     3781 ccttgcgcgg cgccgggggc cgtggccgcc ggacctctcg gcggcccgtc ctcattcctc
     3841 ccccgcgact gccccggacg ggccgccggg cgggtcggtc cggtacgccc ccggcagccc
     3901 gccggggtcg gtgccgagct tgcggtagac ggcggagagc agccggccga cggtgacctc
     3961 gccggtggac agctccgccg cgatcgccgc cggtgtcgcg ccggtggccg cgcgggcggc
     4021 ggccgcgtgt tcctgctcag tgagggtggc ggtcccggtg gcgggcagcc gcaggggccg
     4081 caggcccgcc gaagtgagct ccccgcgagc ccgtgaggcc agttcgtcgg cgccgcactg
     4141 cagggcgccc tccagacccc ggtagagctg ctcggcggcc tccgccgggc ggcccgcccg
     4201 gcgcagcgcc gtcccgtggg cgaccagcga gcaggccagc tggtggccgg ccggggagcg
     4261 ctccagcgag tcgacggact cctccaggag cttcatccgc tccgctcccc cggacacctc
     4321 ggcggcgatc cgcagggtgt gcccaatcgt ggaggcggct ccgaactgcc gggcgcgggc
     4381 gacggcctcc atggccgtgg cgcgggcccg gtccggggcg gtggacgcct cggcgagcgc
     4441 caggtgcggc tgccagggac accaggcggg attgcgcatg ccgcgctggt tcagccggcg
     4501 gcccacggcg gccagttcca cggcggcctc cttcgccata ccgcgggcga gcagcagctc
     4561 gccgtagacg ccctgggcgt cggggaaggt gacggcggcg gggaacgggg cgtggaagtc
     4621 gtggtccgcg gccagttccg tcgcctcggc cacccggccg cgggcgagca gcacctcgat
     4681 gaggaccgcg acggagtacc actggacggg ggtgccccgg ccgacgcgct cggcgagccg
     4741 cagtccggcg cgggcgaagt cctcggcctc ggcgagccgg ccgcgccgga agcggacgta
     4801 gccgagcagc agatagccga acgacagatg ggcgccgcgc cagccctggc gttcgaactc
     4861 ggcgatcccg tcggcgaaca gctcctccgc ccggccgggc cggtccgcgt acatgtgcac
     4921 cagggcgacc agcaccggga cctcgaagcc gcagtccgcc tcggcccagt gcagccctcc
     4981 gtccagggcc cggcccgcgt ggcgcagcgc ggtgccggac ggctcgccgc gcaggacggc
     5041 gtcccaggcg cgcagcccga tgatgtaccg ctcggtgagg tcgcggccgg tcagccggtc
     5101 ggcgagccgg gccagccggc gggagcgggc gggtgagccg ggctcgtccg cccggaacgc
     5161 gtcccacatg aactgctcgg cctgcatccg cagccggacc cggggatcgg tggcggtacg
     5221 ggccgcgtgg ccgacggtgt cggcggcctc gtcgagccgg tcgctgtggg cgagtgcctg
     5281 ggagaggtgg aagaggatcc cctcgcgcag ggcggggtcg cccgccggct cctccagcgc
     5341 ggcccggaga tggttgacgg tggtggcggg ctcgagcagc agggaggcgc agccgagttc
     5401 gtacaggacg gcggcgcgct cgccggggga cgggggttcg cgcagggccc ggccgaggta
     5461 gctgcgggcg gcttccgggg cgcccgcgcg cagcgtctcg cgggcggcgt cccgcagttg
     5521 gcccacgacc caggagtcgc cctcggggtg ggtctcgagc agatggcggg cggcggccga
     5581 ggctccgagg ccggcgtcga cgaccgacca ggccgcccgg ccgtgcagcg cgacccgcgc
     5641 cgcgtcgggg atcgcccggt agacagcggt ggcgatcagc gggtggacga attcgagggt
     5701 cgcgccgccg gtcagcaccc gggcgccgcg cagtgtgtcc gcggcctcgg ccgcctccgc
     5761 cgcgccgatg cccgcgatgt ccgcggcgag ctccggggag atctccgtcc ccagcaccgc
     5821 ggcggcccag gccagccgga cggcgggcac gcccagccgt tccagccggg tggtgagccc
     5881 gctgcccttc accgcggccg ccagttcgcg cagcaggtgc gcgctggtcc ggtcggggcg
     5941 caggccccgg tcgcggacct tggcggtcag ctcgacggcc tcgaaggggt tgcccgcggt
     6001 gacggaccag cactcgcggc agaacgcgtc gtccgcgtgc tccccgaccg acgcgcgcac
     6061 caggtcgcgt atcgcgtccg cggtgagcgg ttccaggtcc aggggccggt ggccggtact
     6121 gccgggcagt ccgcggaacg acccggcgtg ctcgggcagt tcctcgggcc ggtaggcgac
     6181 gacgatcagc atggacagtt ccgcggcgcg cggcgcgaac gctgcgagcc agcccagcga
     6241 ttcgggatcg gcccagtggg cgtcgtccag gacgaggacc accggggcgc gccgctgggc
     6301 gagatgggtg accacccagt ccaggccgtc gcgcaggccc tgcgggtcgg gtgccgcacc
     6361 gtcgcccgcc gcgcacaggc ccagcgccgg gccgacgatc ccgtaccagc tgccgagcga
     6421 ggagcgcagt tcgctctcac cggatccggc gagctgcggc tgcaggagct gccgggccac
     6481 atggaaggcc acccgctgct cctggtcgcc gccgcgggcg gacagtacgg tgcagccctg
     6541 gtcggccgcg cgccggcggg tctcggccag gagcgtggtc ttgccgagcc cggcggtgcc
     6601 ggagaaggcc agcaggccgc cgcgcggccg ctcgcggctc tcgccgccgt ccgcccgcaa
     6661 gccggtgagc tggcgcaacg cctcgtccac agcggcgagt tcgggctctc gttcgagcaa
     6721 cgggcgccct gaacgggccc tgtgctccgg catcgtgcac cccctggtac caccgcgtac
     6781 gccgggcgcc cgatgcgctc ggcgctcgcg cgtccgatgc cacctcagcg tacgcccgcg
     6841 gggcggtccg ggaccctgtc ccggacctgc cgcggcccta ccttccgagg tcctggttca
     6901 tcgccccagc gcagagtgct ggaacccgtt gtccgatgtc tgttcgaggg ccttggccag
     6961 cccggcgtga tcggtgccga ccttgcggta gacggcggac agcatgcgcg tcacctcgcg
     7021 ttccgcggcg cccatctcct tcgcgacctc ggcggtggac cggccgcccg cgacctgttc
     7081 cgccaccgtc cgctccggcc cggtgagcgt gtcggtcccg gtactgcgca gctgcagcgg
     7141 gcgcatcccc gccgccgcga gctcgtcacg ggcccggccg gcgagcgcgt ccgagttgca
     7201 gtgcagcgcg ccttccagac cggcgtgcaa ccggtcggcg gcgtcctgcg gtagtccggc
     7261 ccggcgcagc gcggcaccgt acgcgacctg cgcgcgggcc agttcgaacg ccgagggtga
     7321 gcgttcgaga tggctgacgg cctcggccag cagccgcaga ccgtcggcgc caccggtcac
     7381 ttcggcggac gcgtgcagcg cctgcccgat cgccgacgcg gtaccgaact ggcgggcccg
     7441 ctgaacggcc tcccggatgg tgtccgcggc ccgttcgggc tcgacgagcg ccaccgcctg
     7501 ggcgaggtgc agctgccacg ggcaccagcc gggattgcgc atgccgcgcg cctccagccg
     7561 ctggccgacc accgtgagat ggcgttcggc gtcgccccgc atgccctggg ccagcagcag
     7621 ttcgctgaag accgtctggg agtcggggta gaccaccgcg ttcgggatca cctcgccgta
     7681 gttgtacgtg tcggcgagct cctgtgcctc gtgggtacgg ccgcgggcca gcaggatctc
     7741 gatgaggatg ccgatcgcga accactgcgc gggcactccc ggccccaccc ggtcggcgat
     7801 gcccagcccg gcgtgcacca ggtcctcggc ctcggcgagc cgcccgcggc ggtagcggat
     7861 gtacccgagg agcgtgaagc cgaacgacag gtgcgcgccg cgccagccct tgcgttccag
     7921 ctccgcgatg cccttggtga acaggtcctc ggcgcggccc ggctggtcgc agtacatgaa
     7981 ggtgagggcg accaggaccg gaacctcgaa gccccagttc tcgtcggtcc agctgaggcc
     8041 gtcgccgagg gcctcctcgg cgtagcggac cgcgacgggg gccggttcgc cgcgcaccat
     8101 cgcgtcccag gcgcgcagtc ccaggatgta gcgttcggcc gggccgcggc cggtgagatg
     8161 gtccgccagc cgggccaatc gccgggagcg ggcgggcgag tcctgttcgt cggcccggaa
     8221 ggcgttccac atgaactgct cggcctgcat gcgcagccgg gtgcgggtgt tgttggcccg
     8281 gccggcctcg gcctcgacgg ttctggcggc ctccgccatc cggccggtgt gtcccagcgc
     8341 ctgggcgagc cggtaggtga tggcctcgcg cagctccggt tcgagttccg gctcctccag
     8401 ggcggcccgc aggtggttga ccgtgttcgc gggctcgttg aggagcgagg agcagccgag
     8461 ttcgaagagc acggccgcgc gctcaccgta gggcgggggt tcgcgcaggg cgcgggcgag
     8521 gcagcgctgg gccgcctcgg gcgcaccggc ccgcaggtac tcgcgggcgg cgccgcgcag
     8581 ttgttgcacc acccactcgt caccctcggg gtgcagttcc agcaggtgcc gggcggcggt
     8641 ggcggcaccc agtcccgctt ccgtcacggc cgatgccgcc tcgccgtgca tcccgacgcg
     8701 cagcgcgctg gggatcgccc ggtagacggc ggtggcgatc agcgggtgga cgaactccag
     8761 ggtggagctg tcgttggtgc cgaccgtcag gatgcgcgcg gcccgcagcc gttcgaaggc
     8821 gtcggccgcc tcctcgcggc cgagcgcggc gacgcccgcg gccagcggcg gtgcgatgga
     8881 cgtgccgagg acggccgcgg cccaggcgaa gcggaccgcg gacgggccca gtttctcgat
     8941 ccgctcgatg aggccgctgc ccttgacggc ggaggccagt tcgcgcagtt ccgggatctc
     9001 ctcgcgctgg cccttgagtt cgcggtcgca gatcttggcg gtgagctcgg tgacctcgaa
     9061 ggggttgccg ccggtgaccg cccacgcctc acggcagaac gcctcctcgg cgctctcccc
     9121 cacggcgtcg cgcactatgc gccggacggc gcccggggtg agcgccacca ggtcgaaggg
     9181 ccgggagccg tgccggccgg cgagtttgcg gaacgccatc gcgttggcgg gcagttcgtc
     9241 cggccggtac gcgacgatca ccagcatcgg cagttcctcg gcgcgcgggg cgaaggtggt
     9301 cagccacgcc agcgactccg cgtcggccca gtgcgcgtcg tccaggatca ggacgacggg
     9361 cgcctgctgg acggcgaagc gcgtcaccac ccagtccagg ccgtcgcgca cgccggtggg
     9421 atcgggggcg ccgtcgccgg ccgaggccac cagcccgacc gccggggcga cgatgtcgta
     9481 ccagctgccc agtatccggc ggtgctcctc ctcggaggcc gccgcgagca ccggctggac
     9541 gagctggcgg acgacatgga aggccatgcc ctgctcctgc tcgccaccgc gtgcggacag
     9601 cacggtgcag ccgcgcgccg ccgctcgcct gcggacctcg gcgagcagtg cggtcttgcc
     9661 gcccccggca ggacccgcga aagcgagcag cccgccgtgc ttcgtgccgg accgagtccc
     9721 gcagagatcg ttcaaagcgc cgtcgagcgc gacgagttcg gactcacgtt cgagaaccaa
     9781 gcgattcact cgtcccaatt gttctaccgc gtctggcatg tccgttcccg ttctcgttgc
     9841 ctgttcggca ggtagcgccg agcgtacgcc cgccgggacg ctctgtagtg ccccctgggg
     9901 atatccacgt cggacgaacg ggtagatggc aaacgccagt tcactttccc catggtccgg
     9961 gcggctccgg accaccgcga cgcaacccga ggtgggcacc ttgtcggaca ccacagcccc
    10021 cagcggcccc atccagcgcg acatcctcgc ggaacgcacc accctgctga gcattccctt
    10081 ccccgggcgg tcgagcccgc acaccgaccg agcccgccgg cacaccctca agtggctgcg
    10141 cgacctggcg atactccgtt tcgaccgcga cgtcgaggag tacgacgccc tacggctgga
    10201 gcgcctgatg gcgttcttct acccccgtgc caccggaccc gacctcgacc tcgccgccga
    10261 tttcaacgcc tggttcttca tcttcgacga ccagttcgac ggccctttgg ggcgtcggcc
    10321 ggacgacgtg gagcgcgagg tcgacacgtt ggtgtcgatc ctctacgaac caccttcccc
    10381 cgtccgtggc gccgccaacc cgtcggacaa ccccctcgcg gacggattcc gcgacatctg
    10441 ggtccgttcg gcggccggca cgccgaccgt gtggcagcac cgcttccgcg accactggcg
    10501 ggactatctg cgggcctacc actgggaggc gctgaaccgg acgcggcggc ccgccatgac
    10561 cctcgagacc ttcctgcggg gccgccggga ctccatcggc gtccagccgt gcctggactt
    10621 cgccgagcgc tgcggcggct acaccctgcc ggacatgctg cactcgggcc cgctcgccga
    10681 gatgcgggag atcaccagtg atgtggtgat cttcgtgaac gacatcatgt cggtggacaa
    10741 ggagttggcc gccggggacg tcaacaacag tgtgatcctg ctgctcgaca gcagcgacca
    10801 cacgctggag ggggccgtgg aactcatcgc gcgggctgcc aacgcgcgcg tgcagcggtt
    10861 ccagatgctg gccgcgcggc ttcccgcggt gctcgacgag tacaacgccg cgcccgcgct
    10921 gcggacgcag gtggaggact atgtgcgcgc catgcgccat gtgatgcgcg gcaatctcga
    10981 ctggtccctg gagaccgcgc ggtaccgcgc ttcgggggtc gccgcggtga gcggcggcag
    11041 acagcggccg tggtcggatc tcttcggcgc ggaccgcgcc cgccccggtg gcctcggctg
    11101 aaccggccgt gaacggagcg gcggaacggc cggggccgca cgggagtgcg gccccggtcc
    11161 ctcgcgcggc ccggatgcgg gcggacgccg acttcctagg cagggtaggt gcggcccgcg
    11221 aagcgccgct cgaaaccgtc gccggcgttc gcggtgacgg tgtagtcgta gccgccgtcg
    11281 gccgccgatg tgagcgcgac ctgctgggta ccgcccgccg cgacggtcgc cgtactgccg
    11341 ccggaaccgt ccccggcggc gttgccgccc acggtgaaga ccaccgccgc gccaccgccg
    11401 ttggtcagcg tcagcgccag gttccgcggc gtcgcgcggg cgatggccac ggccgcctcg
    11461 gggtgcccct tggccgcgtt cgaccaggtc cgcacatcgc ccttgaagcc gcgcagatag
    11521 ccgtcggggc cgtgcgcgtc gatgtcgtac aggccgccgc cgtacgtctg ggcgctgaag
    11581 tagtcctgca cgctgccgcc gacgggaacg gtgtagcgcc agttgtcgta cgtgcggtgg
    11641 ttgacggtgt acatcgcgaa cccggcgccc agcgtcccgg tgttgaccac cttgatccag
    11701 atgcggccgg tgctcgtctc ggtccacgac gtcgtgtcga agccgtagcc gatcctccgg
    11761 gccggccggg tgcccgactc ctggaccggc gccacctgcg ccgacggcgg ggcggcgtcg
    11821 ggcagcgagt tctgggcgtc gcaggcggcg accagcgcgg cggtgtcggg gagcgagggg
    11881 aacgtggtgt tcttcgtgct gaagtcgaag gcgctcatca ggtcaccgca gacggtgcgg
    11941 cgccaggcgg agatgttggt ctccttcacc ccggtccagt tctccaggaa ccgcagcggc
    12001 gaggtgtggt cggcgacctc ggagttgacg tagccgccgc ggctccaggg cgagatcacg
    12061 atcatcggca cgcgcgggcc gagaccgatg ggcaccccgc cgatgaactc gtccgcggtt
    12121 ccggcgggcg ggacgggcgg cgccacatgg tcgaagaagc cgtcgttctc gtcgaagttg
    12181 aggaagacca cggtcttggc ccagacggcc gggttcgccg cgagcgactc caggacgtac
    12241 ttcgaggtgt agttcgcgcc gtacgccggc gggtagtccg ggtgctcgct ctggttggcc
    12301 ggggccacga cccagctgac ggccggcagc gtaccgttct tcacgtcctg gttgaacgcg
    12361 tcggcggaac gccgctgcat cccgttgacg tagagcggtg acgtggtggc ggcgctcttg
    12421 aagttcttga accaggcgag cgggttgtcg tcgtagttgt cctgctgctg gtagacccgc
    12481 caggagatgc ccgccgactg caggcgctcg gcgtaggtgg tccaggagta ccccttctcg
    12541 gagttgtccg tgaccggccc gccgttcctg cccgccgggt cgacggtggc ggtccactgg
    12601 tacagccggt tggggttggt cggcccctgc acggaacaga agtactggtc gcagagggtg
    12661 aacgactcgg ccagcgcgaa ctggaacggg atgtcggcgc gctggtagta ccccatcgac
    12721 caggcgctct tggccggcac ccagttgttg tacttgccgc tgttccaggc gctgtgggtg
    12781 cccgaccagc cgtggtcgag gtcccgcacc cgctgcgcgt ccgtcgtcgc ggtgttcagg
    12841 tgccagggca gtacgagact gccgccggag ggaccgttcg cggtctggcg cagcacgtcc
    12901 tggccgttgg ggaagcgcag ccgcgaccgg tcgccgtagc cgcgtacacc cttgagggtg
    12961 ccgaagtagt gatcgaacga acggttctcc tgcatgaaga tcaccacatg ctcgacatcg
    13021 tcgagcgtgc cggccgccga ggtggcggcc atggcctgct ggatggaggc gggcagcgtg
    13081 ccgaacgcgg cggcggcgcc ggccgctccc aggaatccac ggcgggacaa gggcgtcaag
    13141 gcgactcctc ggtcagggga cacaggtgcg gggtcgcgcc gaattgaacg gggagaacgc
    13201 gacgggcgcg ccaatacgcg cggagactgc catggccact tgccacacac aagatgacgg
    13261 gcgacccaag cacgggcaaa gccgccggac gtcctgatac ccgccaccgg gacggccgga
    13321 accagccacc ccggagcgga gacctaatgt tatattcgcg gcgatgcatt agctgatgcg
    13381 cccagcaggt ggagtgccgg caagtggact tccggcgggg cgacaagaac cgggatcaca
    13441 cccggtcgac ccaccgccgt tccgacggcg gccggcacaa ggagctgccg tggccgtgaa
    13501 ccgtcccgac cccgtaccgg cggtcctgga gagtcagtcg cggctgcggg cgctgctcgg
    13561 cgggctgacc gacgccgacg tccgcgcccc gagcgcactg cccggctgga cccgcgggca
    13621 cctgctcagc catgtcgaag gggtcgggtt cgccctggcc cggcaggcgc gttacgccct
    13681 caaggacgag ctgatcgatc cctacgacgg cgggcggccg gcccgagacg ccgccatcga
    13741 ggccggacac ggccgctcgg ccgccgaact gcgggcggcc gtcaccgcgg cgctcgacga
    13801 ggccgagcag gcgtggacgg ccgtcggccc gcgggacctg gagcggccgg tgcgctatcg
    13861 cgacgccacg ctgtcggccg ccgcgctcgc ctggtggcgg gagttggaga tccacacggc
    13921 ggacgccgcg atcgggtacc ggaccgcgca gtggtcacgg ccgttctgcg cgcacgtcct
    13981 ggacttcctc gcgccgcggg taccggacgc ggtgcggctg acgctcgcgg cgtcggacgg
    14041 cccggaggca cttgtcctcg gggacggcga accggtcacc gtaggcggtg cgctcaccga
    14101 cctcaccgcc tggctggcgg gacgcgagcc gctgggcccg ctggacagcg gagtggcgcc
    14161 gctgcccgaa ctcgggccgt ggccgtagtc gtagccgtgg ccgtagccat gctggtgtcc
    14221 ggccccgaac agccggccgc cgggcctcgg tgacgaggcc cggcggccgg tggggcgtac
    14281 gggacggacg cctcaggtga ggtcgaactc gccgtcacgc gcgccgagta cgaaggcgcg
    14341 ccattcggcg ggcgtgaaga tcagcgacgg cccgtccggg ctccgcccgt cccgcatcgc
    14401 gatgtagccc tcgataaagg cgatctggac gtcgcccgtg ccctgactgc tggactgcca
    14461 gtccgcgctc gcaagatcca gctgcggctt cttaccgttg gtcaacggct gtccgatggt
    14521 gctctcggcc acgtccgctc tcctcccacg tcgtcatccg cgacccagcc tagccaccgg
    14581 gccctttgcc cgacaggcaa tgggacaagc tgcccggata caccgcccga tcaggtggtg
    14641 ggccggtccg cgccgacgag ccacatcgag aagaactgcg cgccgccgcc gtacgcgtgg
    14701 cccagcgccc ggcgggcccc ttccacctgg tgctcaccgg cctggccgcg tacctgcagc
    14761 gccgcctcgg cgaaccggat catgccggac gcgccgatcg ggttggtgga cagcaccccg
    14821 cccgacgggt tgacggggag atcgccgtcg agttcggtga cgcccgcctc ggtgagcttc
    14881 cagccctccc cctcggcggc gaagccgagg ttctccagcc acatcggctc gtaccaggag
    14941 aacggcacgt acatctcgac cgcgtcgatc tcccggcgcg gatcggtgat cccggcctgc
    15001 cggtacacat cggcggcgca gtccttgccg gcctgcgggc tgacgtagtc cttgcccgcg
    15061 aacatcgtcg gctcgctgcg catggccccg ccgtgcagcc aggcgggcgg gcgcggcgtc
    15121 cgggccgcgc cctcggtgtc ggtgagcacc atcgcgaccg cgccgtcgga ggacgggcag
    15181 gtctcggagt agcggatcgg gtcccacagc atgggggcgg cccgcacctt ctccagggtg
    15241 atgtccttct cgtgcaggtg ggcgtagggg ttcttcaggg cgttgcggcg gtccttgaac
    15301 gcgacgaggg agccgatgtg gtcgggcgcc ccggtgcggc gcatgtaggc gcgtacgtgc
    15361 ggggcgaaga agccgccggc gccggcgagc agcggctgct ggaacgggat cggcagcgag
    15421 agcccccaca tggcgttgga ctcggactgc ttctcgaacg cgacggtcag tacggtgcgg
    15481 tggacgcggg ccgcgaccag gttggaggcg accagcgcgg tcgagccgcc gaccgagccc
    15541 gcggtgtgca cccgcagcat cggtttgccg accgctccga gggcgtccgc cagatacagc
    15601 tccggcatca tcacgccctc gaagaagtcc ggggccttgc cgatgacgac cgcgtcgatg
    15661 tcggcgaagg tgagttcggc gtcggcgagc gcccgcaggg ccgcctcgcg cagcagcccc
    15721 gcgatcgaca cgtcgtgccg ggccgcgacg tgcttggtct ggccgatgcc gacgacggcc
    15781 acgggtgcct tgctcatttc acatcccctt ccaggacggc gaccaggttc tgctgcaggc
    15841 agggaccgga ggtcgcgtgg gccacggcgc ggtcggagtc gccgcggtgg atgcgggcgg
    15901 ccgcctcgcc gagccggatc aggccggcgg ccatgatggg gttggcggcg agcggaccgc
    15961 cggacgggtt gacgtccacc tcgtcgccca gccgcagcgc cctgcgcagc acgacctcct
    16021 gggaggtgaa cggcgcgtgc agttccgcgg tgtcgaccgg cgcgtcgaag agcccggccc
    16081 gttcggccgc gagccgggtg gacggtgagt cggtgaggtc gcggacgccg aggctgtgcg
    16141 cctcgatccg gtggtcgagg ccgcggatcc acgcgggcct ggcgcagagc cggcgggcgg
    16201 tgtccccggc ggccagcacg atcgcggcgg cgccgtcgcc gaccggcggg cagtcctggc
    16261 ggcgcagcgg ctggacgacg tactccccgc cgtcgcggac ggaggtgagc tgcgcgtacg
    16321 ggttgtcccg cgcggaggcg cggctgcggg cggcgacccc ggcgagttcg ggttcgctgg
    16381 tgtgccccgc gtcgatgagg gcccgcgcct ggagcgcggc gagcgcgacc gggtcgggcc
    16441 acagcggcgc gacgtagtac gggtcgagct ggcgggtcag tacctcgcgg acgtcgccgg
    16501 gcgaggactt gccgtaggag tacaccagcg cggtgtcggc ctcaccggtg aggatcttca
    16561 cccaggcctc gtagagcgcc caggcgccgt ccatctcgac atgcgattcg gagatcggcg
    16621 gccaggcgcc gaccccgtcc agggccatcg tgaaggagaa ggcccggccg gcgaggtagt
    16681 ccgacgaccc ggagcaggtg aagccgatgt cgctggcctt cagttcgacc tggtcgaacg
    16741 cctcgtgcag cacgggcatg agcagttcga cctcggagac ctcggccgtg ctgcgggcgt
    16801 gccggctctg ggcgaacgcc acgatcgcga cgtcccgcat ctagaccatc tccttgtacg
    16861 tgtcgtagcc ggcgtcgggc tctccggtcg gccggtagtg gtcggggaag ccgccgtcgt
    16921 cgctccacac gggttcgacg cgcatgccca tccgcacctg gtcgtagggg aggccgccga
    16981 tgcgcccgtg cagggcgagg tccgcgccgt ccagggcgat gtgcgcgtag acgtacggca
    17041 cttcgatgtc gaggccgcgg gccttgatgt tgacgatgca gaaggtggtg atggtgccgc
    17101 caggtcccac ttccacctgt tcctcggtgg cgacgccgca ggtggggcag gcgccccggg
    17161 gcgggatgta gaccttgcgg caggacgggc agcgttcgcc gatcatcttg cggtcggcga
    17221 gcgcggcgag gtagcgggtc tgggcccggc cggggctgta gacgtagtcg aggcgcgcgg
    17281 gggcgacgat gccggtcacc ggatcggtga actcgccgtg gtgcgcggtg gccgcgcgct
    17341 ccggcggccc ggtcccgtcg tccggttcga agcaggcgat gtcggtgatc gcgccgaccc
    17401 gctcgtcggc ccagcggatc cgtacccgca ttccggtgct gacggcgtcg gggccggccg
    17461 cgtccagggc gtgcagcatc gcggtgtcgg cgccgtcgag gcggaccagg acccaggcga
    17521 agggcgtgga gagcggctgg ttgcgcccgg ggtcggggtt ccaggcccag gtggtgacgg
    17581 tgccggtggc gccgacctcg acgagttccc gcagctccgc cgaggtgacg gggtcgtatt
    17641 cgacgggcgg tacgagcacc cggtcgtcgc cggtgcgcac accgagcacg gtgcgttcgc
    17701 gcaggccggt gaggaacgcg ctctggacgg ggccgagcga gcgggtgaac gggaactcga
    17761 cgaccagtgg tgcgctgagg acttcggtca tggggggctt ctctccttgg gtccctgggg
    17821 tcaggcgcgc ttgaagaccg cggggcgctt ctcggcgaag gcccggggac cttccttcgc
    17881 gtcggcggtg gcgaagatcg gccagccccg ctccagttcg tgcttgaggc cctccgtctc
    17941 ggtcatctcc gcggtgtcgt acacggacgc cttgaccgcc tcgacggcca gcggcccgtt
    18001 ggcgttgatc tgttccgcga tctccagggc tcgcttcagc gccgtgccgt cgggcacgac
    18061 atggccgatc aggccgatgt cctttgcctc cgccgcggag taggggcggc cggtgagcag
    18121 catctccagg gcgtgggtgc gggggatctg ccggggcagc cgcacggtgg agccgccgat
    18181 cgggaagagc gcgcgccgga cctcgaagag cccgagggtg gcgctctccc cggcgacgcg
    18241 gatgtcggtg ccctgcagga tctcggtgcc gccggccacg cagtacccct cgacggcggc
    18301 gatcaccggt ttgcgcggcc ggtggtgccg gagcatcgcc ttccagtgca gatcggggtc
    18361 ctccttcatc cggtcgcggt actcctgccc ggccatcgcg ccgtcgtcgg aggccagcgc
    18421 cttgaggtcc atgccggcgc agaaggtgcc gccggccccg gtgaggacga tggagcggat
    18481 cgagtcgtcg gcgtcggccg ccagccagcc gtcgtacaga ccgaccagca tcggcagcga
    18541 gagggcgttc ttcgcctcgg gccggttcag ggtcagtacg agcgtcgcgc cgacgcgctc
    18601 caccgtgaga tgttccgtgc cgcccatggc cggcctccaa ggtcgcaatc ttccgtcgcg
    18661 gacctagaac aggttgcagt aggcgcaggt cgagttcaat agttttctga ctaccagtca
    18721 gatttcccgc ccgggaaccc ttcccacctc gctccaggag ggttctaatg accgccgaga
    18781 ccttcgcagc atcaaggctg gaggagccgt ggagtacaac cttgccgacc tcttcgagtc
    18841 ggtcgtggac gtggtcccgg accgggaggc gctcgtctac atcgaccacc ccggatcggg
    18901 cgccgagcgg cggctgacgt acgcccagct cgacgcggcc gcgaaccgga tcgcgcacca
    18961 cctgatcggc agcgggatcc ttcccggcga ccacgtcgga ctgcatctct acaacggcat
    19021 cgagtacctg cagacggcac tggcctgcgt caaggcccgt gccgtgccgg tgaacgtcaa
    19081 ctaccggtac gtggaggagg agctggtcta cctctaccgg gacgcggatc tgacggcact
    19141 ggtcttcgac gccgagttca ccggccgggt ggccgccgca ctgccgcaca ccgagaagct
    19201 gcggcacctg gtcagggtgg gcgttccggc cggggacgag cgggaaccgg ccatcgcgcc
    19261 ggtggccttc accgacgccg aggcggccgg atccccggac cgcggcttcc cgccgcgctc
    19321 cgcggacgac cagttcatca tctacaccgg cggcaccacc ggtatgccca agggcgtcat
    19381 gtggcgccag gaggacctct tcttctccgg catgggcggc ggcgccccca ccggcgagcc
    19441 ggtcaagcgg cccgaggagc tggcggagcg ggtcgccgcg ggcggcgagg ggctggtctt
    19501 cttcccgacc ccgccgctga tgcacggcac ctccacgctc accgcgttca tcggcttcaa
    19561 cttcggccag aaggtcgtca tccaccgcaa gtacgtgccg gacgaggtgc tgcgcaccat
    19621 cgagaaggag aaggtcagca gcgtctcgct ggtcggcgac gccatgctcc ggccgctggc
    19681 ggacgccctc gccggaccgc tggccggcac cgactgctcc tcgctgttca ccatctccag
    19741 ctcgggcgcg atcatgtccg agaccgtccg cgcccagttc caggcgctgg tcccgacggt
    19801 catgatcctg aacaacttcg gctcctcgga gtccggcttc aacggaacgg ccaccgacga
    19861 ctccagcccc gccaacggct tccggctgcg ggtcaactcc catatcgcgg tggtcgacct
    19921 ggccacgctg gagccggtca cggtcggcga accgggacgc atcgccctgc gcggacacgt
    19981 accgctcggc tactacaacg accccgagaa gaccgcggag acgttcttcc agcgggacgg
    20041 cgagcggtgg gtgctgctcg gggacatggc gacggtcgac gaggacggcg tcgtcaccgt
    20101 tctcgggcgc ggttcgcagt gcatcaacac cggtggcgag aaggtctatc cggaggaggt
    20161 cgaggaggcg ctcaaggcgc accccgacgt ctatgacgca ctggtcgccg gggtgccgga
    20221 cgagaagtgg ggcaatcacg tcgccgccgt cgtccagccg cgcgacggtg cggacccact
    20281 gaccctcgac gacatccagg cgcactgccg cacccggctg gccggctaca agatcccgcg
    20341 cagcctcgtc ctcatggaca gcatccagcg ctcccccagc ggcaaggccg actaccgctg
    20401 ggcccgttcg gtggccaccg acgcggcgga ggccgggcgg tagtcgggcg gccgcccgag
    20461 gggacgtccc gggccgttgt cagtggcggc gcttacgatc agcggtcagg atcccccgtc
    20521 gatcggagtg cgcgcgtgtc cgccgattcc acctcgttcc aacgtcccga gccgccgtac
    20581 tacgccgtca tcatcacgac actgccgagc ggcgaggacc cggaggggta cgcggacgcg
    20641 aaccgccgca tgggaccgct ctccgccaag tggcccggat acctgggccg cgagtcggag
    20701 agcggtcccg acggccgcga tctgctggtg gtctattact cggacgcgga gtccatagcc
    20761 tcctggaagg ccgatccgga gcacctggag gtgcaacggc tgggccggga gcggtggtac
    20821 gcctcgtaca gcgtcgaagt ggcccgcgtg gagcgtgcct acggcttccg gcgcgactag
    20881 ggcctccgac cgggtgaggc ggtgcggccg cacggcacat cgcctcaccc cgtggattct
    20941 gtacctacta gtatgtacac tcggatcatg gagacctcgg aacggttgat cgcgagcacc
    21001 caggaactcc tctgggaacg cggctacacc ggcaccagcc ccaaggcgat ccagcagcac
    21061 gcgggcgccg gccagggcag catgtaccac cacttctccg g
//
