LOCUS       NZ_CP048835            22629 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. So13.3 chromosome, complete genome.
ACCESSION   NZ_CP048835
VERSION     NZ_CP048835.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. So13.3
  ORGANISM  Streptomyces sp. So13.3
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K., Quezada-Solis,D., Khalil,Z.G., Capon,R.J.,
            Andreote,F.D. and Barrientos,L.
  TITLE     Genomic and Metabolomic Analysis of Antarctic Bacteria Revealed
            Culture and Elicitation Conditions for the Production of
            Antimicrobial Compounds
  JOURNAL   Biomolecules 10 (5), 673 (2020)
   PUBMED   32349314
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K., Lamilla,C., Abanto,M., Maruyama,F., Jorquera,M.A.,
            Santos,A., Martinez-Urtaza,J. and Barrientos,L.
  TITLE     Antarctic Streptomyces fildesensis So13.3 strain as a promising
            source for antimicrobials discovery
  JOURNAL   Sci Rep 9 (1), 7488 (2019)
   PUBMED   31097761
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9564008)
  AUTHORS   Nunez-Montero,K. and Barrientos,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2020) Centro de Excelencia en Investigacion
            Biotecnologica Aplicada al Medio Ambiente (CIBAMA), Universidad de
            La Frontera, Av. Francisco Salazar 01145, Temuco, La Araucania
            4811230, Chile
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-JAN-2020
            Assembly Method                   :: Unicycler v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 140.0x
            Sequencing Technology :: Illumina MiSeq; Illumina HiSeq; Oxford
            Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005860785.2-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 04:03:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,707
            CDSs (total)                      :: 8,616
            Genes (coding)                    :: 8,274
            CDSs (with protein)               :: 8,274
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 342
            CDSs (without protein)            :: 342
            Pseudo Genes (ambiguous residues) :: 0 of 342
            Pseudo Genes (frameshifted)       :: 109 of 342
            Pseudo Genes (incomplete)         :: 268 of 342
            Pseudo Genes (internal stop)      :: 24 of 342
            Pseudo Genes (multiple problems)  :: 52 of 342
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:45:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1067643
            Orig. end                         :: 1090272
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048835.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Laboratorio de Biologia
            Molecular Aplicada, Universidad de La Frontera, Avenida Alemania
            0458, Temuco, Chile.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22629
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="5"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22629
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22629
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12629](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12629)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    1447..1462
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    1733..1747
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.52"
                     /tool="antismash"
     misc_feature    complement(1733..1753)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(1899..2936)
                     /locus_tag="C8250_RS05060"
                     /old_locus_tag="C8250_005085"
     CDS             complement(1899..2936)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852987.1"
                     /locus_tag="C8250_RS05060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005085"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_138351390.1"
                     /transl_table=11
                     /translation="MLRVHFTPHDLQNIRIAQHPDPLWELVCSICRLQTRQGPLDFGHW
                     RGTAYERLRRDPVVKGALHLLRLLIPASGYIPDFLTPSNTGGELFAGLDQVRGTPRGQL
                     NRELTRLAESRPVPVWATTMGRPGADGLVPLTKALATYHRALLQPFWPRIRTAVDNDIG
                     RRASTLLGGGTQALLEGLRPLARWNSPTLEVDYPVDRDLHLAGRGLLLVPSYFCWGRPT
                     ALADPGLTPVLVYPVAKVPLDGEGATEQGLVRLLGRTRAAVLAEVANRNARTTSEVAEA
                     VGVTLPSVSYQIGVLRDGGLVASRRDGKYVLHTATPLGLRLLGGGTPGLVDSPLPQGPF
                     SLCSK"
     misc_feature    complement(2733..2735)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2918..2929
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(3106..3891)
                     /locus_tag="C8250_RS05065"
                     /old_locus_tag="C8250_005090"
     CDS             complement(3106..3891)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /locus_tag="C8250_RS05065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005090"
                     /product="serine protease"
                     /protein_id="WP_138351389.1"
                     /transl_table=11
                     /translation="MKALVRLAVAGMAAAGLVVTLSGSASAVLGGKPATTDTYPYLIAI
                     ETPDHQELCTGALIAPAKVLSAAHCFDAMDVTGLRFIGGRTDLGTTKGQVRHAVKVKVH
                     PDYQGFAGDYDAAVVTLDRALPYRTVPVARPADSALYGYGRPATVLGWGRTGTETAVAN
                     SDAAAAGRRLKEATLKLAPMSDCGPWSSTSAVKICGLPRSAVPESVCAGDSGGPLIAGG
                     RVIGIVSSGNKYCTPDTAYSTFSRVSSVAAGLGLLTRSP"
     misc_feature    complement(3880..3882)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4032..5477
                     /locus_tag="C8250_RS05070"
                     /old_locus_tag="C8250_005095"
     CDS             4032..5477
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017809.4"
                     /locus_tag="C8250_RS05070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005095"
                     /product="AlkA N-terminal domain-containing protein"
                     /protein_id="WP_138351388.1"
                     /transl_table=11
                     /translation="MTTYSAVRTTGIYCRPGCGAKPHAENVRTFELAGAAEAAGYRACL
                     RCRPYRVAGTVADDTPELVCRAVQLIIGGTLDEANEAALGARLGVSARHLRRMFHDHLG
                     VTPDQFARSRRAHFARRLLDDSDLSIAEVAFASGFGSLRQFNRAIREVFRSAPSDLRDR
                     RRRGDRLTADGGLVLRMPFTAPYDWDATLDFLAERAVPGVESIESGRYRRTIALDGAPG
                     MLEIGPGGSDHLRLRAHLPYWEGVIHVVERAARLVGIDADPVLPSAQLIADTALGPLIT
                     SRPGVRVPGAWGPFEVAVHAVLRQELPAQRARAALGALARAYGPPVDGLGHGLTHAFPS
                     AGTLADVPPDAYGLPDGAGGTVSALARAVVSGSVHLDGGEPLAELVASLVTVPGLGAAA
                     AHHVALRLGARDAFPAGDPDVRRAVQQLASSLEVSDSPGSPDSSADLDAVSAPWRPWRA
                     LATVHLLVGDRHQAPRTAPSDSR"
     gene            complement(5487..6314)
                     /locus_tag="C8250_RS05075"
                     /old_locus_tag="C8250_005100"
     CDS             complement(5487..6314)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484444.1"
                     /locus_tag="C8250_RS05075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005100"
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_138351387.1"
                     /sec_met_domain="PEP_mutase (E-value: 6.6e-76, bitscore:
                     253.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALDQKEQARVLRALHAQPPLVLPNAWDPGSAVAIEAAGATAIA
                     TTSAGVSWAVGVPDGGGMSRAAALDALRRIVAAVSVPVTADIEAGYGATPQEVASTITA
                     VLATGAVGVNIEDSPGVRGEPLLDPAAQADRLAAARDSARAADVDLCINARTDTYLAGV
                     GAPSERLAATLARAERYAAAGADLLFVPGLIDPEAIRALVDGPLPINVMAHPGAPTVAE
                     LAALGVARISVGSAVAQAAYGLAADAARELLGSGTYVSLEAAMGYGELNDLLR"
     gene            complement(6445..7002)
                     /locus_tag="C8250_RS05080"
                     /old_locus_tag="C8250_005105"
     CDS             complement(6445..7002)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538314.1"
                     /locus_tag="C8250_RS05080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005105"
                     /product="MepB family protein"
                     /protein_id="WP_138351386.1"
                     /transl_table=11
                     /translation="MSTGPGTSTGPEPWTSSAGPLHSDLLAAKTWVYDVNGFVCSRPVP
                     EPESADYGAHEFTLDGASVRFRVARTTPTKIGQFVTVWKRSPEGPIQPFDSTDAADLLV
                     VSSREDQHFGQFVFPREVLGERDVVSRNGVGGKRAFRVYPPWATAVNRQARASQAWQLR
                     YFLRIPEDGPADAGRARALYHP"
     gene            <7186..>7569
                     /locus_tag="C8250_RS43350"
                     /old_locus_tag="C8250_005110"
                     /pseudo=""
     CDS             7186..>7569
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606965.1"
                     /locus_tag="C8250_RS43350"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="C8250_005110"
                     /product="MBL fold metallo-hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRLATAAFARHTRSIRHPSRTLDPAADPFPLRLTDDVHLCGHSSS
                     HTAGADAYLLQRPSGQLMMVDTPRWNSGPAARYEARGPVTDVLLTHRDHAAHGRRYADR
                     FGGRLWIHEGDLDASPDADHVIRG"
     gene            7697..7966
                     /locus_tag="C8250_RS05085"
                     /old_locus_tag="C8250_005115"
     CDS             7697..7966
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS05085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8250_005115"
                     /product="hypothetical protein"
                     /protein_id="WP_187144733.1"
                     /transl_table=11
                     /translation="MTEFLWPRGADAEDTAAFEAWLDARGWEIDPTMFMAGVGGPAVQV
                     RRIGETWQDGDDGLLILPGESVTFDAWRMSVIRTTGMGMLCRSS"
     gene            8156..9127
                     /locus_tag="C8250_RS05090"
                     /old_locus_tag="C8250_005120"
     CDS             8156..9127
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985151.1"
                     /locus_tag="C8250_RS05090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005120"
                     /product="aldo/keto reductase"
                     /protein_id="WP_138351385.1"
                     /transl_table=11
                     /translation="MRFRTLGRRPDATPGPGVSTLCLGAMPFGTHVDEATAFAILDRFV
                     ERGGTFVDTANCYSFWEDGGRGGESEELVGRWMTARGNRDRIVLATKVGAQPTGPGDWP
                     GNAEGLSAKAIRGGVEGSLRRLGTDRVDVLYGHIEDRATPLAETVGAFGELVAEGTVGI
                     LGVSNQVTWRIERARTLAREHGLAGYSCIQQQYTYLRPKPGAAFGTKEHVTPELLDYVR
                     AEPDLTLLAYTPLLSGAYTDPAKSVPEQFDHPGAAAQLTAVREVAAETGATAGQVVLAW
                     LLGGELPIIPIIGASSTAQLDESLDAPDLDLTPSQRDRLDQA"
     misc_feature    complement(9363..9376)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.85"
                     /tool="antismash"
     misc_feature    9574..9587
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.02"
                     /tool="antismash"
     gene            9663..9815
                     /locus_tag="C8250_RS05095"
                     /old_locus_tag="C8250_005125"
     CDS             9663..9815
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS05095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8250_005125"
                     /product="hypothetical protein"
                     /protein_id="WP_164292695.1"
                     /transl_table=11
                     /translation="MELNIRVIAQCVSPVRWVHVRAAITIIVIVVLVLFGHGETSMFDA
                     LARRP"
     gene            complement(10001..10732)
                     /locus_tag="C8250_RS05100"
                     /old_locus_tag="C8250_005130"
     CDS             complement(10001..10732)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="C8250_RS05100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005130"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_187144734.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.4e-11,
                     bitscore: 43.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.3e-08, bitscore: 32.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF13471 (E-value: 6.1e-15, bitscore: 54.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDLYIPAHIHDSVSPHGGSVLLNAHSGQWYALNSTAHTLWQEWQ
                     RTGDFDSAVDAMAHRYPRERRTQVRSDAEELAAGLAARGLVVSGEPGERPGPGEWPGPG
                     ERAEKFPVARTAPRRPSHRGLPQLAFAIALLLLRLPFRLTVALVGARQRWCRAAATEEQ
                     ALWAVIAVEAVARRFPGRAACLELSLSAVVAMALLGRRLDWCIGTVDDPYRFHAWAEVD
                     ELPVTHPSDSESALFRRVLSI"
     aSDomain        complement(10472..10681)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C8250_RS05100_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="4.50E-14"
                     /identifier="RREFam002.1"
                     /label="C8250_RS05100"
                     /locus_tag="C8250_RS05100"
                     /protein_end="87"
                     /protein_start="17"
                     /score="43.2"
                     /tool="antismash"
                     /translation="GGSVLLNAHSGQWYALNSTAHTLWQEWQRTGDFDSAVDAMAHRYP
                     RERRTQVRSDAEELAAGLAARGLVV"
     gene            complement(10746..12629)
                     /locus_tag="C8250_RS05105"
                     /old_locus_tag="C8250_005135"
     CDS             complement(10746..12629)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033561.1"
                     /locus_tag="C8250_RS05105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005135"
                     /product="albusnodin/ikarugamycin family macrolactam
                     cyclase"
                     /protein_id="WP_138351383.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.3e-23, bitscore:
                     83.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLTRLPAQCAPYVAGTFPVPAAVPQSVDADFPAHGMSRVWPGL
                     SSLWSWGRWRSGELRGVTYKGAGLVTLGQCFADDRQLTAGLVQAVESDRWEALIRWPGS
                     YLVIMARDDGLLAFTDLAGQFPLYYCPVPGRVAFGSRPAIAAAAAGIPARPDRATLAAQ
                     ILCPTADPLFGERSVLDGVHRLGGGQALRIDAAGHPETWTYDPLIPDRHVSLADGAEAL
                     RAALTAAVGARVDLGERLTADFSGGLDSTSLAFLAAHRTRTPLPVFVYHHPDAPAGDLE
                     HAERFARLDGRLELTVLPGSRQTLTYHGLDQVRPAGQPEAAAVNSARLRVRLAGIAAGG
                     SAIHLGGEGGDALLVPAAGYLADLARQGGPRTFGRHCRDVAKARREAPTAVAARALRLS
                     RTSPAGALQRLADRLERPAEGIPQWLDTIAWWPDPGSEAGWLTGAMRGELAELARSRAR
                     TETVTPGVGVGDRTALTELRIAATVQQQLSDTAREFEVWPHAPFLDNDVVRACTGLPSY
                     HRADPRAVKPLLGAALAGLVPEPVLTRRGKGNYTAEDYQGARLHAKEIRSLLTGSRLAD
                     LGIIDQGAVIGSLDRVLMGIRAPLPALNRLLSAELWLRGLDRRPLRTDPPS"
     misc_feature    complement(12453..12455)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12839..12852
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.83"
                     /tool="antismash"
     misc_feature    12839..12853
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.12"
                     /tool="antismash"
     misc_feature    complement(13016..13031)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.36"
                     /tool="antismash"
     gene            complement(13176..14366)
                     /locus_tag="C8250_RS05115"
                     /old_locus_tag="C8250_005145"
     CDS             complement(13176..14366)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.4"
                     /locus_tag="C8250_RS05115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005145"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_198359529.1"
                     /transl_table=11
                     /translation="MSHRDSNRKRIILAIMIKPDTQAGIARRTILSQATVSTAVRDLEK
                     DGIVRMERNSAAQGKGGRGVRVCLQGAVNVAVGVDLGFNHVTVIARRVDEQYDRVKVQQ
                     STDGANRGLAHVIPLVKGMIEEAVAETGRTSDDIISVGIAVPRMIDPRSGTFAAPVLPP
                     WSGEGGDPAIELARALGVRVVMDNDANLGALAEQTYGGSDHLETVVYVKASTGIGSGLI
                     VGGNLLRGRSGIAGELGHLTMDPHGVICQCGGRGCLETIIGAEYLIDQVRKSQLGNSAD
                     LPGSLAALIAKAHANDAVCVRALQDAGRLLGRALAQLCNLFNPDVIVLGGQLAAAKDLV
                     LKPCREALERFALSGAVDPSTDFELRLSNLKQRAEALGALVLGLSSILSDEEIEKS"
     misc_feature    complement(14446..14459)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.8"
                     /tool="antismash"
     misc_feature    14501..14517
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            14743..15219
                     /locus_tag="C8250_RS05120"
                     /old_locus_tag="C8250_005150"
     CDS             14743..15219
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8250_RS05120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8250_005150"
                     /product="hypothetical protein"
                     /protein_id="WP_138351381.1"
                     /transl_table=11
                     /translation="MNALQRGDVLLQAAVAEAAPGESAMARGRVDLLLELDDDTLFTLT
                     KVAVTFLMRIHRAEGQERTALPDDGTGPNDSARSYTIGLLNAWSAREGKSVKSLFATAA
                     ADPQRREEIRRDPFDFAIERALELATKHVGPHTLVRQLCKSIAREDRSMAQDWP"
     gene            complement(15240..16730)
                     /locus_tag="C8250_RS05125"
                     /old_locus_tag="C8250_005155"
     CDS             complement(15240..16730)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265341.1"
                     /locus_tag="C8250_RS05125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005155"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_244808974.1"
                     /transl_table=11
                     /translation="MIRPHSLRARLTCGLVVLLAVSCAAVGVAAVLALRGFLTERLDQQ
                     LSDAGGQFPASLEHAGEHGEPDADNHADTRRQSPGTFGARLLAGVVTDAAVVRSGTDTT
                     VELNAADKAELAAVPVDGHAHDIRLSALHRYRVRALAGDDQDVLITGLPLHGVEETVHR
                     LELVEAAVFGGALVVTGVAGALWVRWSLRPLRRVAATATAVTRLPLDSGEVALPLRVPD
                     ADPRSEAGQVATAFNLMLGHVGDALSKRHTSEERLRRFAADASHELRTPVASVRGHAEL
                     ALRHPGPVPAEVRRSLERVAAESARMGVMVDDLLLLARLDAGRPLERRPVDLTRLVLDA
                     VDDARAAGPGHRWVLDLPEEPVTVPGDAHRLQQVVANLLANARIHTPDGTEVAVRLRTV
                     PSGDGTVEVRVADNGPGVPEAVRATLFERFARADRRRPGAGSGAGLGLAIVAAVVEAHD
                     GTVTARSRPGRSEFTVRLPLGDGAGGAKEEPEVGAGPW"
     gene            complement(16727..17473)
                     /locus_tag="C8250_RS05130"
                     /old_locus_tag="C8250_005160"
     CDS             complement(16727..17473)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380777.1"
                     /locus_tag="C8250_RS05130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005160"
                     /product="response regulator transcription factor"
                     /protein_id="WP_138351380.1"
                     /transl_table=11
                     /translation="MDIPPAAPPLPSLTRPDGTPVRVLVVDDEPDLLEVLAGVLHYEGW
                     QVRTAADGASALTAARDFQPDAVVLDIMLPDFDGLSVLRGLRDRQPGICVLFLTARDAV
                     EDRIAGLTAGGDDYVTKPFSLEEVLARLRGLLRRAGMTRRRPEGALLSVGDLVMDEEAR
                     EVTRDGQTVELSPTEFELLRYLLRNPRRVLSKAQILDHVWSYDFGGQAHIVELYISYLR
                     KKIDVGRVPMIHTVRGAGYVLKPGTP"
     gene            17598..18980
                     /locus_tag="C8250_RS05135"
                     /old_locus_tag="C8250_005165"
     CDS             17598..18980
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129606.1"
                     /locus_tag="C8250_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005165"
                     /product="ferredoxin reductase family protein"
                     /protein_id="WP_138351379.1"
                     /transl_table=11
                     /translation="MATTYGHRAARRRSAPPGPPAPRGRRSPARFILSLVGAGAVTVLA
                     LWWLDTASVVGPAGWLIGAGRIAGLLTGYGCAVLVALMARVPALERGVGSDRVARWHAM
                     AGRYTVCLLLAHIVLIIWGYALQARTSVVRETTTVVLDYPEMLKGTAGALILVAVGVFS
                     ARAVRRRVSYETWYYLHVMTYLALFLAFGHQLALGADFAGNAAARNAWYALYLGVAALV
                     VWFRVLVPVRLNVRHRLRVAAVVREAPGVVSVLIQGRRLDGLRAEPGQFLRWRFLTGGL
                     WWTSSPYSLSAAPRPDQLRITVKAAGAHSAALALLRPGTRVWAEGPYGALTSARRTRSK
                     VLLLAGGVGVTPLRALFETLPARPGELTLLYRARTPGDLALRSELESIAQSRGARLYYA
                     VNAADGTRAAITVTGLRTILPDIAQHDVYLCGPEGMAQESYDALRAAGVPAGRIHHESF
                     EL"
     gene            18986..19450
                     /locus_tag="C8250_RS05140"
                     /old_locus_tag="C8250_005170"
     CDS             18986..19450
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018534948.1"
                     /locus_tag="C8250_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005170"
                     /product="FMN-binding protein"
                     /protein_id="WP_138351597.1"
                     /transl_table=11
                     /translation="MRTHPLRRIVLSAAATVTGVVLLLSLKPHAQHQSVAQQNPNQGPS
                     PTAAGSAPSASAGSTSGGVRTVDGDTIQTRFGPVQVRITLTGSKITAVTVLQVPDENGR
                     DQEVAEFSVPQLTQEALDAQSAGIDTVSGATYTSEGYIRSLQSALDRSGG"
     gene            19485..>20189
                     /locus_tag="C8250_RS05145"
                     /old_locus_tag="C8250_005175"
                     /pseudo=""
     CDS             19485..>20189
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891415.1"
                     /locus_tag="C8250_RS05145"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C8250_005175"
                     /product="FAD:protein FMN transferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGTVFSFDVRGDTGPRTRTALAAATAWLHHVDEEFSPYRTGSQVS
                     RLARGELTPDECSAEVREVLRLCADAEWLSGGWFSARYAGGIDPTGLVKGWAVERAAAM
                     LHSAGAPAVCVNGGGDVQLHGGPWRVGVADPLRPGAVVTVVEARHTLAVATSGPAERGC
                     HILDPHTGAPPADALASVTVVARGLTDADAWATAACAMGADRARGWLEDLPGAEAFAVT
                     SEGGTWQTSGFAR"
     misc_feature    21464..21484
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.03"
                     /tool="antismash"
ORIGIN
        1 acatgggtgc cccaggtgga atgggcaccg ccgcccggcg acgaaccgtc gcaggccggg
       61 atgttgggga gccaggccgg tccgcggaca tagatgttgg agacccagct gccgccgatg
      121 tcgggcagat gcgaccagac gtcgttggtg taaccctcgg ccgtgaccga ctgggcgtgc
      181 ttctggcagt cgatacggat cgccgtcgga ccgctgagcg tggtgtacac cgggcccgac
      241 gtcgacggtg tggtgtgcgt gcggacgtcc gtgccccagg tggagttggg accgccgacg
      301 cctccgccgc ccccgctgcc ggagcccgac ggccggaccg cgcccatgta gtcgtggtgg
      361 ttggacatgg gtgacacccg gatcttctcg ttggactgcg gggcctcggc gatcagcccg
      421 gtgcccagat agatcgcggt gtgatggatg ttcgcggagg tgccgaagta gacgatgtcc
      481 ccggcccgca acacactctc acccatggga ggaccgaacc gcaccgacca cggcgcacgg
      541 tacgccgagt ccgccgtacg gtcaccgatg atgtcgtacc cggcggcctt gtagtaggcg
      601 aagcggacgt atcccgagca gtcgaagccc ttgcggtacg ggtcgttggc actgcggacg
      661 gggtcggact ggtcgaccga gccgaatgtc gcctgcggcg gagagacgct gtgcccgccg
      721 ccccaggtgt accaggtgtc ctgcgcgatg acggagcagg cggccgcgat ggcggcggcg
      781 cccatcgggt cggtgtcggt gtgcggtgcg cacggggtgt tggggttggg gtccgatccg
      841 cccgatgcgg cgaagctgac cgcggtggac accgccttgg ccgccatacg gttcgccgtc
      901 gcgccgtggt ctccggcgcc gtactgggtg tgcgcgggaa ggctgtacgc gaactgctgc
      961 gccaggtcgt ccgtgctggg cggacccggg cggttgcaga cgtggtcgtc ggtgcggcac
     1021 acgtcgaagt accggccgtc gccgatgaat ccggcgaagg ctcccggaac attcagccgc
     1081 cccagcagcc cgccgtcggc gacggcggcc gtgccggtgc tgaagtcagg gttgatggtg
     1141 agcatcgcac cggcctgggc catgccgatc tggccgttgt tgcggctggg gtcggcgacc
     1201 gtgagcacgg cgcctatggt gtccgcgtgg gactgcacga cgggcagctg cagcgccgac
     1261 ttcacgacgt gcgcgcccat cgaatagccc agcaggatca gatggggatg gttggcgcac
     1321 cccgcgtaga agttgacctc gctggccagc cggtcacggc cgatgcccag ccccgtccag
     1381 tagtccggca ggccgccggg ccacgggcgg gagatcagtg acgccgggta cttgaggtta
     1441 cggaccttga tcgcctggtc ctggacgccc ttgtcgtgca gggactggac gatccccgcg
     1501 atgaaccagc tgttgactcc gctggaaccc cactccatcc ccgcgccctg gtgcgtggtg
     1561 tcctcctcgg tgccgtacgc cgagatcacc acccaactgg gcccgcagac cgggtccccc
     1621 ggatcaggat tcggatagtc ggcacgggcg tccggggccg cgccgagcgt cgtggtcgcc
     1681 accatcgcca gcaggacgga gaggagcaga agccaccgtg gcagcctcgg cctggtagtc
     1741 acattcactg tatgagagac ctttcctgcg ctgccgtttc tgcactgccg cggcatcggc
     1801 cgaagggacg cggggaacat caccgcgaag accgttgccg gtgcaccatc accttgccgg
     1861 tgcggggaca gcatgcggcg gggcgggcgg acgggcaatc atttcgagca caggctaaac
     1921 gggccctgcg ggagcggact gtcgaccagg cccggcgttc ccccgcccaa cagccggagg
     1981 cccagcgggg tcgccgtgtg cagaacgtac ttgccgtcac ggcggctggc cacgagcccg
     2041 ccgtcccgca gtaccccgat ctggtagctg acgctgggca gggtgacgcc gacggcttcg
     2101 gccacctcgg aggtggtccg ggcgttccgg ttggccacct cggccagtac cgctgcccgg
     2161 gtcctgccca gcaggcgcac cagtccctgt tccgtcgcgc cctctccgtc gagcggcacc
     2221 ttcgccaccg gatagacgag caccggcgtc aggcccgggt ccgcgagagc cgtcggccgg
     2281 ccccagcaga agtacgaggg caccagcagc agcccacgcc ccgccaggtg caggtcgcgg
     2341 tcgaccgggt aatccacttc cagcgtcggg gagttccatc gcgccagcgg gcgcagtcct
     2401 tccagcagcg cctgggtgcc gcctcccagc agagtgctcg cccgccggcc gatatcgttg
     2461 tcaacggcgg tccggatacg cggccagaag ggctgcaaca gcgcccggtg gtaggtggcg
     2521 agcgctttgg tgagcgggac gagcccgtcg gctcccggcc ggcccatcgt ggtggcccag
     2581 accgggaccg gacgggactc ggcaagccgc gtcaattcgc ggttcagttg tcctcgggga
     2641 gtgccgcgca cctggtccag gccggcgaac agttcgccgc cggtattgct cggtgtgaga
     2701 aagtccggaa tgtagcccga agcggggatc aataaccgca gcagatgcag cgcccccttc
     2761 acgacgggat ctctgcgcag ccgttcatat gccgtgccgc gccaatggcc gaaatcaagc
     2821 ggtccctgtc tggtctgcag acgacagata ctgcacacca gttcccacag cgggtcggga
     2881 tgctgggcaa ttcgaatgtt ctgcaggtcg tggggggtga agtgaacgcg gagcatgcag
     2941 cctctttcgc tcgcaggccc aatgcgggtc gcggccgtac cggttcggcg cggccatggg
     3001 taaagacccg caccagctct ccaaggttgc cccctgcccc gacttcgcgc ggggacagga
     3061 ggcggaacgc ggcagacctc gcccgcaatt cctctttatc gttgctcaag gagaccgtgt
     3121 gaggagtccg agaccggcgg ccaccgaact cacccgggag aacgtggagt aggcggtatc
     3181 cggggtgcag tatttgttgc cgctgctcac gataccgata acgcggccac cggcgatcag
     3241 tggtccaccg gagtccccgg cgcagacgct ctccggcacg gcacttcggg gaagcccgca
     3301 gatcttcacg gccgaggtgg aggaccacgg gccgcagtca ctcatcggcg ccagcttgag
     3361 cgtcgcctcc ttcagccggc gacccgcggc ggccgcatcg ctgttcgcca cggcggtctc
     3421 cgttcctgtc cgcccccagc ccaggaccgt ggccgggcgc ccgtagccgt aaagggcgga
     3481 atccgcgggc cgggccaccg gaacggtcct gtacggcagc gccctgtcga gcgtgacgac
     3541 cgcggcgtcg taatcacccg cgaaaccctg gtagtccggg tggaccttca ccttcaccgc
     3601 gtgccggacc tgccccttcg tggtgcccag gtcggtacgc ccgccgatga agcgcaggcc
     3661 ggtcacgtcc atggcgtcga agcagtgtgc cgcgctgagc accttggcgg gagcgatcag
     3721 tgccccggtg cagagctcct ggtggtccgg agtctcgatc gcgatcagat aggggtacgt
     3781 gtcggtcgtg gcgggcttgc cgccgagcac cgccgaggcc gaacccgaca gggtgacgac
     3841 gagtcccgcc gcggccatgc cggccaccgc gagacgcact aaagccttca tcgaatctcc
     3901 tggaagtgtc tccggctact ggatcactga gacgagaccg cgagacgcct ggttgcaccc
     3961 cggccggaca gcggcgtcat catgtccgga tccggctggc ccgtgcccct tgcggatgcg
     4021 agcctgagca ggtgactacg tattccgctg tacggaccac ggggatctac tgccggccgg
     4081 gttgcggggc caagccgcac gccgagaacg tccgcacctt cgaactggcg ggagccgcgg
     4141 aggcggccgg ctaccgggcc tgtctgcgct gccgccccta tcgtgtcgcc ggcaccgtcg
     4201 ccgacgacac tcccgaactc gtctgccggg ccgtccagct catcatcggc ggcacgttgg
     4261 acgaggccaa cgaggcggcg ctgggcgccc ggctcggcgt gtccgcgcgc catctgcggc
     4321 ggatgttcca cgaccacctc ggggtgacac cggaccagtt cgcccgctca cggcgtgcgc
     4381 acttcgcccg gcggctgctc gacgactccg acctgtcgat cgccgaggtc gccttcgctt
     4441 cggggttcgg cagcctgcgc cagttcaacc gggcgatccg ggaggtgttc cgctccgcgc
     4501 cgagcgatct gcgggaccgg cggcggcgcg gagaccggct caccgccgac ggcggactcg
     4561 tcctgcgcat gccgttcacc gctccttacg actgggacgc caccctcgat ttcctcgccg
     4621 aacgagcggt ccccggtgtc gagtcgatcg agtcgggccg gtaccggcgg accatcgcgc
     4681 tcgacggggc gcccgggatg ctcgagatcg ggccaggagg ctccgatcac ctccgactgc
     4741 gagcgcacct gccctactgg gagggcgtca tccatgtcgt ggaacgggcg gcccggctcg
     4801 tgggtatcga cgccgacccg gtcctcccgt cggcgcagct catcgccgac accgcactcg
     4861 gtccactgat cacctcccgc ccgggggtac gtgtcccggg agcgtgggga ccgttcgagg
     4921 tcgccgtgca cgcggtgctc cgccaggagt tgcctgcgca gcgggcccgc gccgcgctcg
     4981 gcgcgctggc ccgcgcctac gggccgcccg tcgacggact cggacacggg ctcacccacg
     5041 ccttcccgtc ggctgggacc ctcgcggacg tgcccccgga cgcgtacgga ctgccggacg
     5101 gagccggcgg gaccgtcagt gccctggcac gggcggtggt ctccgggtcc gtccacctcg
     5161 acggcggcga accactggcg gaactcgtgg catcgctggt cacggtcccg ggcctcggcg
     5221 ccgccgccgc gcaccatgtc gccctgcgcc tcggcgcacg cgacgcgttc ccggcgggag
     5281 acccggacgt acggcgagcg gtgcaacagc tcgcatcctc actcgaagta tccgattcac
     5341 ccggctcacc cgactcgtcc gctgatctcg atgccgtctc cgcgccctgg cgtccgtggc
     5401 gggcgctggc gacggtccac cttctcgtcg gggaccgcca ccaggcacca cgcaccgccc
     5461 cgtccgacag ccgctgaagc ggaccgtcag cgcagcaggt cgttgagctc cccgtaaccc
     5521 atcgccgctt cgagcgagac gtaggtgccg gaaccgagca actccctcgc cgcgtccgcc
     5581 gccagaccgt aggcggcctg ggcgacggcc gaacccacac tgatgcgtgc gacaccgagc
     5641 gccgcgagtt ccgcgacggt cggcgccccc gggtgcgcca tcacattgat cggcagcggc
     5701 ccgtcgacga gtgcgcgtat cgcctcggga tcgatgaggc cgggaacgaa gagcaggtcc
     5761 gctccggccg cggcgtaccg ctcggcgcgg gccagggtgg ctgcgagccg ttcgctcggc
     5821 gcaccgactc cggcgaggta ggtgtccgtc cgggcgttga tgcacagatc gacgtccgcg
     5881 gcccgcgcgc tgtcccgggc ggcggcgagc cgatcggcct gtgcggccgg gtcgaggagc
     5941 ggctcgcccc gtacaccggg gctgtcctcg atgttgacgc ccacggcacc cgtggcgagg
     6001 accgcggtga tggtcgacgc cacctcctgc ggggtcgcgc cgtatcccgc ctcgatgtcg
     6061 gcggtcaccg gaacggagac cgcggcgacg atgcgccgca gggcgtcgag agcggcggcg
     6121 cggctcatgc cgcccccgtc cggcactccc accgcccacg acacccccgc gctcgtggtg
     6181 gcgatcgcgg tggcaccggc cgcctcgatc gccaccgccg agcccgggtc ccacgcgttg
     6241 ggcaacacca gcgggggttg agcgtgcagg gcgcgcagga cacgcgcctg ttccttctga
     6301 tcgagcgcct tcacggggcc ctcctggttc cacgggttcg ggcgggccga acgaccctct
     6361 accaggtaag actctcccgg tccgccatca ccggtctggc catatccggt cacgcgcccg
     6421 ccgtgctcag gggcgcgccc ggcgctacgg gtggtacagc gcgcgagccc gcccggcgtc
     6481 ggccggaccg tcctcaggga tccgcaggaa gtaccgcaac tgccaggcct ggctagcgcg
     6541 ggcctggcgg ttgaccgcgg tggcccaggg cgggtagacg cggaaagccc gtttcccgcc
     6601 cacgccgttc ctggagacga cgtcccgttc gccgagcact tccctcggaa acacgaactg
     6661 cccgaagtgc tgatcctcgc gggaactgac cacgaggagg tcggccgcgt ccgtggagtc
     6721 gaacggctgg atgggcccct ccggggaccg cttccacacg gtgacgaact gcccgatctt
     6781 cgtcggggtt gtcctggcca cccggaaccg cacggaggcg ccgtccagcg tgaactcgtg
     6841 cgcaccgtag tcggcactct ccggctcggg taccggccgg gagcagacga acccgttgac
     6901 gtcgtacacc catgtcttcg ccgcgagcag atcgctgtgg agcggcccgg cggacgaggt
     6961 ccacggctcg ggaccggtgc tcgtcccagg gccggtgctc atccctgatc tccggtttcg
     7021 gcgtcgccgg cggtgggccc gccggcctgc ggttccaggg tgcgcatgaa catctccatc
     7081 gtgaggtcgg gtgcgtctcc gaacctagcc gagggcactg tcaacgggtc ggagcggccg
     7141 ccggggtccc ggggaagcgg ccggcgcacg acggctcgcc gcccccgtcg gctggccacc
     7201 gccgccttcg cccgtcacac ccggtcgatc cgccacccgt cccgcaccct ggacccggcg
     7261 gccgacccct tccccctgcg gctgaccgac gacgtccatc tgtgcgggca cagctcctcg
     7321 cacaccgcgg gagccgacgc gtatctcctg caacgcccgt ccgggcaact gatgatggtc
     7381 gacaccccgc gctggaacag cgggccggcc gcgcggtacg aggcgcgggg ccccgtcacc
     7441 gatgtgctgc tgacccaccg cgaccacgcg gcacacggcc ggcggtacgc cgaccggttc
     7501 ggcggccggc tgtggatcca tgagggcgac ctcgacgcct ccccggacgc cgatcacgtc
     7561 atccggggca gggtcggggt gtcgggggtc accgtccgcg tatacccaaa atttagcgac
     7621 ttgtcagtgc cgcctggcag gatcagtgtg ctcggtccac gagcgctacg ggggatgtac
     7681 gggggatggg gacagcatga cggaattcct atggccacgg ggggcggacg cggaggacac
     7741 cgccgcgttc gaggcctggc tcgacgcgcg gggttgggag atcgacccga ccatgttcat
     7801 ggccggagtc ggcggtcctg cggtccaggt gcgccggatc ggcgagacgt ggcaggacgg
     7861 ggacgacggg ctgctgatcc tgccgggcga gtccgtgacg ttcgacgcct ggcggatgag
     7921 cgtcatacgg acgaccggta tgggcatgct ctgccgcagc tcgtaggccg tgtcttcaac
     7981 gtcccggatc gcccggccgt cgcgggggac gcgcggccgg gcggatccgg tgtgccggtg
     8041 ggcggtcggg gatgtgcggt cggtggcggt cgggttgagg gcttgacctc aagcgcgctc
     8101 caagtgacag ggttcgcgac gttcccccac ttcctcgcac ccctgcggag cactcatgcg
     8161 ttttcgtact ctgggccgcc gtcccgacgc cactcccggc cccggtgtca gcaccctgtg
     8221 cctgggcgcc atgcccttcg gaacccatgt cgacgaggcc acggccttcg cgatcctgga
     8281 ccgtttcgtg gagcgcggcg gcaccttcgt cgacacagcc aactgctact cgttctggga
     8341 ggacggcggg cgcggcggtg agagcgaaga gctggtcggc cggtggatga ccgcgcgcgg
     8401 caaccgggac cggatcgtgc tcgccaccaa ggtcggcgcc caaccgacag gtcccggcga
     8461 ctggccgggc aacgccgagg ggctctcggc gaaggccatc cgtggtggcg tcgaaggcag
     8521 tctgcgccga ctgggcaccg accgcgtcga cgtgctctac ggccacatcg aggaccgcgc
     8581 gacgccactg gccgagaccg tcggagcatt cggtgaactg gtcgccgagg ggaccgtcgg
     8641 catcctgggc gtcagcaacc aggtcacctg gcgcatcgaa cgcgcccgga ccctcgcacg
     8701 cgaacacggc ctggccggat actcctgcat ccagcagcag tacacctatc tgcgccccaa
     8761 gcccggcgcg gccttcggaa cgaaggagca cgtcaccccc gaactgctcg actacgtccg
     8821 cgccgaaccc gacctgacgc tcctcgcgta caccccgctg ctctccggcg cctacaccga
     8881 ccccgccaag tccgtgcccg agcagttcga ccaccccggc gccgccgccc agctcaccgc
     8941 ggtgcgcgag gtcgccgcgg aaaccggggc cacggccggg caggtcgtcc tcgcctggct
     9001 gctcggcggc gagctgccga tcatccccat catcggcgcc agttccaccg cccagctcga
     9061 cgaatccctc gacgcaccgg acctcgacct caccccgtcc cagcgcgacc gtctcgacca
     9121 ggcctgagat cacgtcacac catggcacca ctgcggcagt tggggttgcc gggacccttg
     9181 caccgctttc ctcgtcgaga ttttgccgaa tccataccgg gcggcttttc tcgcgagcga
     9241 gagcccgacc cgggtgcggc cctggtcggt gcagcggtcg aatttttgcc gggccgccgt
     9301 ccgcgtctcc cgccggtctt caattctcgc cgtacgacgg gcagttccat ggcccgcgga
     9361 cgcgaaccct cgttctcggg gatcccgcca ccagagctca ccgggtgacg aacccacgcc
     9421 cccggcggcg ggtgacaccg cgcccccggg cttcgaattg agggcggaca cgccttgacg
     9481 atccatgcgt ccctgcattt cgaataccgg tcattcataa agggttcgac acagccggac
     9541 gacgtctccc tccaggcttc acatcaggcc gtataaacgc ctgttgcccc atcgcgtaac
     9601 cctgccacag actgaaggag tcaaccggaa ggcctgaaac acccctggga ggaggcagtc
     9661 caatggagct caacatccga gtaatcgccc agtgcgtatc acccgtgcgc tgggtccacg
     9721 tccgggcggc gatcaccatc atcgtgatcg ttgtcctggt tctcttcggg cacggcgaga
     9781 cgtcgatgtt tgacgccctc gctcgccgtc cctgaagtat ccgcagtaca gcagcatccg
     9841 cagtcctttg gaggggctcg gtcgcccacc ggcggccggc cctttcgtca tgtcctgggc
     9901 ccgctcggcc ggctgtgccc gccgaccgcc cgggcgacac cttttcccgc cattgccatc
     9961 cagctaaagg acggcaggca caaagaaacg ttcgtgccgg tcaaatggaa aggacgcgcc
    10021 ggaaaagagc gctctcagaa tcggaggggt gcgtgacggg aagttcatcg acctcggccc
    10081 aggcatggaa ccgataggga tcgtcgaccg tcccgataca ccaatcgagc cgccggccca
    10141 gcagcgccat cgccacgacg gcgctcaggg agagttcgag gcaggcggcc cgtccgggga
    10201 atcggcgtgc cacggcctcg accgcgatca ccgcccacag cgcctgctcc tcggtggcgg
    10261 ccgcccggca ccatcgctgc cgtgccccga ccaacgcgac ggtcagccgg aacgggagtc
    10321 gtagcagcag cagcgcgatg gcgaacgcca gttggggaag cccccgatgg gacggtcgcc
    10381 gcggtgcggt gcgtgcgacc gggaacttct cggcccgctc ccccggaccc ggccactcgc
    10441 ccggacccgg tcgctcgccc ggctccccgg acaccaccag cccacgcgcg gccagcccgg
    10501 cggccagctc ctccgcgtcc gaccggacct gggtgcgccg ctcccgtggg tagcggtgtg
    10561 ccatggcgtc gacggcggaa tcgaagtcgc cggtgcgctg ccactcctgc cagagcgtgt
    10621 gcgcggtgga gttcagcgcg taccactgcc ccgagtgcgc gttcagcaga acgctgccgc
    10681 cgtgcgggga gacgctgtca tggatgtgcg cgggaatgta caggtccggc atgggtgcca
    10741 tctcctcagg aaggtgggtc ggtccgcagg gggcgtcggt ccagaccccg tagccacagt
    10801 tcggcactca gcagccggtt cagcgcgggc agcggcgccc ggatccccat caacacccgg
    10861 tcgagcgagc cgatcacggc cccctggtcg atgatcccga ggtccgccag ccgcgagccg
    10921 gtgagcagcg atctgatctc cttcgcgtgc agccgcgcgc cctggtagtc ctcggccgtg
    10981 tagttcccct tgccgcgcct cgtcagcacg ggctccggca ccagaccggc cagcgcggct
    11041 ccgagcagtg gcttgacagc gcgggggtcg gcccggtggt acgacggcag tcccgtgcac
    11101 gccctgacca cgtcgttgtc gaggaacggg gcgtgcggcc acacctcgaa ctcacgcgcc
    11161 gtgtccgaca gttgctgttg gacggtggcc gcgatacgga gttcggtgag agccgtccgg
    11221 tcgcccactc cgacgcccgg tgtcaccgtc tcggtccgtg cgcggcttct ggccagctcg
    11281 gccagctcgc cccgcatggc cccggtcagc cagccggcct cggatcccgg gtccggccac
    11341 caggcgatgg tgtccagcca ctgcgggatt ccctccgccg gccgttccag tcggtcggcc
    11401 agccgttgca gcgctccggc cggagaggtt cgtgacaggc gcagcgcgcg ggcggccacc
    11461 gccgtgggcg cttcgcggcg ggctttcgcc acatcgcggc agtgccgccc gaaggtgcgc
    11521 ggtccgccct ggcgtgcgag gtccgccaga tagccggcgg ccggtacgag gagggcgtcg
    11581 ccgccctcgc caccgaggtg gatcgcgctg cctcctgcgg cgatgcccgc gagccggacc
    11641 cggagccggg cgctgttcac cgcggccgcc tcgggctggc cggccgggcg cacctgatcc
    11701 agcccgtggt aggtgagggt ctgccgggag ccgggaagaa cggtcagctc cagccgcccg
    11761 tcgagccggg cgaaccgctc ggcatgctcg agatcgccgg cgggggcgtc cgggtggtga
    11821 tagacgaaga cggggagcgg agtacgcgtc cggtgtgcgg cgaggaaggc gagggaggtg
    11881 gagtccagac cgccgctgaa atccgcggtc agccgctccc ccagatccac gcgtgcgccg
    11941 accgcggccg tcagtgccgc cctcagcgct tcggcgccgt ccgcgagcga cacgtggcgg
    12001 tcagggatca gcggatcgta ggtccatgtc tccggatgtc ccgcggcgtc gatccgcagc
    12061 gcctggccgc caccgagccg gtgtacaccg tcgaggacgg agcgctcccc gaacaggggg
    12121 tcggcggtgg ggcacaggat ctgggccgcc agggtggcgc ggtcgggccg tgcggggatt
    12181 cccgccgccg ctgccgcgat ggcgggtcgg gagccgaagg ccacccgccc gggtacgggg
    12241 cagtagtaca gggggaattg gccggccaga tcggtgaacg cgaggagtcc gtcgtcccgc
    12301 gccatgatga cgaggtagct gccgggccac cggatgaggg cttcccaccg gtcgctctcc
    12361 accgcctgga cgagtcccgc cgtgagctgt cggtcgtcgg cgaaacactg ccccaacgtg
    12421 acgaggccgg cccccttgta ggtcacccct cgtaactcgc ccgatcgcca ccggccccag
    12481 gaccacaggg aggacagccc cggccagacc ctgctcatcc cgtgcgccgg gaagtccgcg
    12541 tccacggatt gcgggacggc ggcgggtacg ggaaatgtgc cggccacgta cggcgcacac
    12601 tgtgcgggca aacgggtcag cagggtcatc gcgcgtcccg ggtcggaatg tgctgcgatt
    12661 tcaccgggcc ctaccaataa tactgtgagt tggcgtccgc attgccgctg gaggaactcc
    12721 ccagggtcag ttcccgtaca tggccaagat cggcgaggag cggggcctcg tagactgcgg
    12781 gcccgctgtc ctcggctgac ctcggagaac ccggtccgca ctggacacag aggtcatcgg
    12841 aacactcgtt ccgcgaaagg aaagacatca tgtctccaca atgggtcggc agtcatcagt
    12901 tcgccgcgta gccccggacc gttggacgtc ggggaacacc gtacggcaag atgaaactct
    12961 acctggactg atgcatcatc agttgcctga ttccgccaac gctgcacgcg gcttgtcgca
    13021 catccagtcg aggagtgcca cgtcaggaac ggcacggcct tcggttccga atagcgcggg
    13081 aaacggtacg gatcgcgagt cgatgacatg ggctcaatta attgaaccgg ccggccgacg
    13141 gatttcccgt tccgacttca aatcgatccc gcctgtcagc tcttctcgat ctcctcgtcc
    13201 gagaggatcg agctgagccc gaggaccagc gcgcccagcg cctcggcccg ctgcttcagg
    13261 ttgctgagcc gcagctcgaa gtcggtcgac gggtccacgg cgcccgacag cgcgaaccgc
    13321 tccagggcct ccctgcaggg cttcaggacc agatccttgg ccgcggcgag ctggccgccg
    13381 agcacgatga cgtcggggtt gaagagattg cagagttgcg cgagcgccct gccgagcagc
    13441 cgccccgcgt cctgcagggc acgcacgcac acggcgtcgt tggcatgtgc cttggcgatg
    13501 agcgccgcga gggagccggg caggtccgcc gagttcccca actgcgactt cctgacctgg
    13561 tcgatgaggt actcggcgcc gatgatggtc tccaggcaac cgcggccgcc gcactgacag
    13621 atcaccccgt gcggatccat ggtcagatgg ccgagctcgc cggcgatacc gctgcggccc
    13681 cgcagcaggt tgccgccgac gatgagaccg gagccgatcc cggtcgacgc cttcacgtag
    13741 acgacggtct ccaggtggtc gctcccgccg taggtctgct ccgcgagagc gccgaggttg
    13801 gcgtcgttgt ccatcaccac acggaccccg agcgccctgg ccagctctat cgccgggtcg
    13861 cccccctcac cactccaggg aggcagcacc ggggcggcga acgtcccgct ccggggatcg
    13921 atcatccggg gcacggcgat gcccacggag atgatgtcgt ccgacgtgcg gcccgtctcc
    13981 gccaccgctt cctcgatcat ccccttgacg agcggaatca cgtgcgcgag gccgcggttg
    14041 gccccgtcgg tgctctgctg caccttgacc cggtcgtact gctcgtcgac ccgccgggcg
    14101 atcacggtga cgtggttgaa gcccaggtcg accccgacgg cgacattgac cgcgccctgc
    14161 aggcagaccc ggactccgcg gccccccttg ccctgggcgg ccgagttgcg ctccatccgg
    14221 acgatgccgt ccttctccag gtcgcgcacg gcggtggaga ccgtggcctg ggacaggatc
    14281 gtgcgacgcg caataccggc ctgcgtatcc ggtttgatca tgatggcgag gatgatccgc
    14341 ttgcggttgc tgtcgcggtg actcacggcg ggacggaggt gcgcacgtaa gtcaagcatg
    14401 gagtcccccg acgaccagca gtgatgatta caacgaagtt gaaggcaata ataatgtcag
    14461 gtgtatcttc aattcaattg attcaccaca tcgaatccaa gtgttccaaa atatcgaaca
    14521 tgtacacccg gaagtcgatc agcctcttcc gatcttggcc gtaaaccgat ccctccgacg
    14581 agtgttccgg cggtcctcca gcggaacttg aggggtggcc cggcgcctcc cgagacggat
    14641 tccagcaccg cgcgagtcac cggtgacaga cctggacggc ccgcctcgcg cggtaatccc
    14701 gcgagtcccc cggccccaca cccaacgatc tccgtgctcg acatgaatgc ccttcagcgg
    14761 ggcgatgtac tgctccaggc cgccgtcgcc gaagccgctc ccggcgagag tgccatggcc
    14821 cgcggcaggg tcgacctgct gctcgaactc gacgacgaca ccctgttcac cctgaccaag
    14881 gtcgcggtga ccttcctcat gcggatccat cgggcggagg gccaggaacg gaccgcgctc
    14941 ccggacgacg ggaccggccc gaacgactcc gcccggagtt acaccatcgg gctgctcaac
    15001 gcctggtccg cccgcgaggg caagtccgtc aagtcgctct tcgccaccgc ggccgcggat
    15061 ccgcaacgcc gggaggagat ccgccgcgat ccgttcgact tcgcgatcga gcgggcactg
    15121 gaactggcca ccaagcacgt cggcccgcac acgctcgtac ggcagttgtg caagtccatc
    15181 gcgcgggaag accgctcgat ggcccaggac tggccctgag ccgaccgcgg ggccgcgcac
    15241 taccacggcc ccgcacccac ctccggctcc tccttggcgc cgccggcgcc gtcaccgagc
    15301 ggcagccgca ccgtgaactc gctccggccc ggccggctgc gggcggtgac cgtgccgtcg
    15361 tgcgcctcga ccacggcggc gacgatggcc aggcccaggc ccgcaccgct gcccgcgccg
    15421 gggcgccgcc ggtcggcccg cgcgaaacgt tcgaagagcg tcgcgcgcac cgcctccggc
    15481 acccccgggc cgttgtccgc gactctcacc tcgaccgtcc catcgcctga cggtacggtc
    15541 cgcagccgca ccgcgacctc ggtcccgtcc ggggtgtgga tgcgggcgtt ggccagcagg
    15601 ttcgccacca cctgctgcag ccggtgggcg tcgccgggga cggtgacggg ctcctccggc
    15661 agatcgagca cccagcggtg accggggccg gcggcccgtg cgtcgtccac cgcgtccagc
    15721 accagccgcg tcaggtccac cggccggcgc tccagcggcc ggccggcgtc cagccgggcg
    15781 agcagcagca ggtcgtcgac catcacgccc atccgcgcgg actccgcggc cacccgctcc
    15841 agcgaccgcc gtacctcggc cggcaccggg cccgggtggc gcagcgccag ttccgcgtgg
    15901 ccgcgcaccg acgcgacggg ggtgcgcagt tcatggctgg cgtcggccgc gaaccggcgc
    15961 agccgttcct cgctcgtgtg ccgcttggac agggcgtcgc cgacatggcc gagcatgagg
    16021 ttgaaggcgg tggccacctg tcccgcctcg ctgcgcggat ccgcgtccgg gacccgcagc
    16081 ggcagggcga cctcgccgct gtccagcggc agccgcgtca cggccgtggc ggtcgcggcg
    16141 accctgcgca acggccgcag cgaccagcgc acccacagcg ccccggccac accggtcacc
    16201 accagggcgc cgccgaagac ggccgcctcg accagttcga gccggtgcac ggtctcctcg
    16261 acgccgtgca ggggcagacc ggtgatgagc acgtcctggt cgtcgccggc cagggccctg
    16321 acccggtagc ggtgcagggc cgacagcctg atgtcgtggg catggccgtc gaccggaacg
    16381 gccgccagtt ccgccttgtc ggccgcgttg agctccaccg tggtgtcggt gccggagcgc
    16441 accacagcgg cgtcggtgac cactcccgcg agcagccggg cgccgaaggt gccgggcgac
    16501 tggcggcggg tgtcggcgtg gttgtccgcg tcgggttcgc cgtgctcccc cgcgtgctcc
    16561 aggctcgccg ggaactggcc gcccgcgtcg ctgagctgct ggtcgaggcg ctcggtgaga
    16621 aagccccgca gcgcgagcac cgccgcgacg ccgacggcgg cgcagctgac cgcgagcagc
    16681 accaccagcc cgcaggtcag ccgggcgcgc agcgagtgcg ggcggatcac ggggtgcccg
    16741 gcttgaggac gtatccggcg ccccgcaccg tgtggatcat cggaacgcgt ccgacgtcga
    16801 tcttcttgcg cagatagctg atgtagagct ccacgatgtg ggcctggccg ccgaagtcgt
    16861 acgaccagac gtggtccagg atctgcgcct tgctcagcac ccggcggggg ttgcgcagca
    16921 gataccgcag cagctcgaac tcggtcggcg acagctcgac ggtctgcccg tcccgggtca
    16981 cctcccgcgc ctcctcgtcc atgaccaggt cgccgacgct cagcagcgcg ccctcgggcc
    17041 gccgccgggt catgcccgcg cggcgcagca gcccgcgcag ccgggccagt acctcttcga
    17101 ggctgaacgg tttggtgacg tagtcgtcgc cgcccgcggt gaggccggcg atccggtcct
    17161 cgacggcatc gcgcgcggtc aggaacagca cacagatccc gggctgccgg tcccgcagtc
    17221 cgcgcagcac ggacagcccg tcgaagtccg gcagcatgat gtcgaggacg acggcgtcgg
    17281 gctggaagtc ccgggccgcg gtgagcgccg aggccccgtc ggcggcggtc cgcacctgcc
    17341 agccctcgta gtgcaggacc ccggcgagga cctcgagcag gtccggctcg tcgtccacga
    17401 cgaggacccg gaccggggtg ccgtccgggc gggtcaggga gggcagcggg ggtgcggcgg
    17461 gagggatgtc catggtccgt ccagcatgcc gccccaacct ctgagtttcc catgagaccc
    17521 gccccgggcc tccggttcag agctgattca gaggttgcgg cggcacagtg ggccgtcagc
    17581 cgacgaaagg ggacatcgtg gcgaccacct acggccaccg ggcggcccgg cgccggtccg
    17641 cgccgcccgg gccacccgcg ccgcgcggcc gccgctcacc ggcccgcttc atcctttccc
    17701 tggtcggggc gggtgcggtc acggtgctgg cgctgtggtg gctggacacc gcctcggtcg
    17761 tcgggccggc aggctggctg atcggcgcgg gccggatcgc cggcctcctc accggctacg
    17821 gctgcgccgt cctggtcgcc ctcatggcca gggtgcccgc cctggaacgc ggggtgggca
    17881 gcgaccgggt ggcccgctgg cacgcgatgg ccggccgcta caccgtctgt ctgctgctgg
    17941 cccacatcgt cctgatcatc tggggctacg cgctgcaggc ccgcacgagc gtggtgcggg
    18001 agaccacgac cgtggtgctg gactatccgg agatgctcaa ggggacggcg ggtgcgctga
    18061 tcctcgtcgc cgtcggcgtc ttctccgcgc gtgccgtacg ccgccgggtc agctacgaga
    18121 cctggtacta cctgcacgtc atgacctatc tcgcgctctt cctcgccttc ggccaccaac
    18181 tcgccctcgg cgccgatttc gccgggaacg cggcggcccg gaacgcctgg tacgcgctgt
    18241 acctcggggt cgctgcgctg gtggtgtggt tccgcgttct cgtccccgtc cggttgaacg
    18301 tgcggcaccg gctgcgggtc gcggcggtcg tacgcgaggc gcccggcgtc gtctccgtcc
    18361 tgatccaggg gcgccggctg gacggactgc gcgccgagcc gggccagttc ctgcgctggc
    18421 ggttcctcac cggcggactg tggtggacct ccagtccgta ctcgctgtcg gccgcccccc
    18481 gcccggacca gctgcgcatc accgtcaagg ccgccggtgc ccacagcgcg gcgctggccc
    18541 tgctccggcc cggcacccgg gtctgggcgg agggcccgta cggggcgctg acctccgccc
    18601 gccggacccg ttccaaggtg ctgctgctcg ccggcggggt gggtgtcacc ccgctgcgcg
    18661 cgctgttcga gacgctcccc gcccgccccg gcgagctgac cctgctgtac cgggcccgca
    18721 caccagggga cctggccctg cggtcggagc tggagtcgat agcgcagtcc cgcggagccc
    18781 gcctgtacta cgccgtcaac gcggccgacg gcacccgcgc cgcgatcacc gtcaccggcc
    18841 tgcggacgat actgcccgac atcgcacagc acgacgtgta cctgtgcggg ccggaaggca
    18901 tggcgcagga gtcgtacgac gcactgcgcg cggccggtgt gcccgccggc cgcatccacc
    18961 acgaatcctt cgagctgtga gcgccatgcg aacccatccc ctgcgccgca tcgtgctgag
    19021 cgcggcagcc accgtgaccg gcgtcgtcct cctgctgtcg ctgaaaccgc acgcgcaaca
    19081 ccagtcggtg gcgcaacaga acccgaacca gggaccctcc cccacagcgg cagggtccgc
    19141 cccgtcggcg tcggcgggtt cgacgtccgg cggggtccgg accgtcgacg gggacaccat
    19201 ccagacgcgg ttcgggccgg tacaggtgcg gatcaccctg accgggtcga agatcaccgc
    19261 ggtcaccgtg ctccaggtac ccgacgagaa cggccgggac caggaggtcg ccgagttctc
    19321 cgttccgcag ctcacccagg aggccctcga cgcccagagc gcgggcatcg acaccgtctc
    19381 cggcgcgacg tacaccagcg aggggtacat ccgctccctg cagagcgcgt tggacagatc
    19441 cggtggctga caccccggat cggctgcggc acgtggagca cgtgatgggc accgtgttct
    19501 cgttcgacgt ccgtggtgac acgggtccgc gcacccgtac cgcgctggcc gccgccaccg
    19561 cctggctgca ccacgtggac gaggagttct cgccctaccg gaccggcagc caggtcagcc
    19621 ggctggcccg cggcgagctc acccccgacg agtgctcggc ggaggtacgg gaggtgctgc
    19681 ggctgtgtgc ggacgcagag tggctcagcg gcggctggtt cagcgcccgg tacgcgggag
    19741 ggatcgatcc gaccggtctc gtcaaggggt gggccgtgga gcgggcggcc gcgatgctgc
    19801 actccgcggg tgcgcccgcc gtctgcgtca acggcggcgg cgatgtgcag ctgcacggcg
    19861 gaccctggcg ggtgggggtg gcggacccgc tgcggcccgg tgccgtggtg accgtcgtcg
    19921 aggcccggca cacactggcc gtggccacct ccggccccgc cgaacgcggc tgccacatcc
    19981 tcgacccgca caccggcgca cccccggccg atgccctcgc ctcggtcacg gtggtcgccc
    20041 gcggcctgac cgacgccgat gcctgggcca ccgccgcctg cgcaatgggc gcggaccggg
    20101 cccgcgggtg gctggaggac ctgccgggag cggaggcctt cgcggtcacg tccgagggtg
    20161 gtacgtggca gaccagtggc ttcgcgcgga cccactccgg cgcgaacacg gcccgggaaa
    20221 cgctgaaggg cccggccgct ggtcgcggcc gggcccttcc gtaccccttg tcagctggtg
    20281 tagtagccgg tcaggtcggc cagcaggtgg acattgccca ggaggttgta aaagtcgacc
    20341 ttcccgttca ccaccggaac cacgaccagg ttcggaatcg tctgcttcgc cacgaagttg
    20401 agattcgaaa cccccggccg cggctgcccg tccggataga cactcacgaa gccaccggag
    20461 gtcggcgcga ccgccgtcac gttcaggacg accgccgtca cacccgtggc cggcagcccc
    20521 gcgcgtccgg cgatctgcag ggtgatggtg ccgccggggc cgacgggggc gtggatgcct
    20581 ccggtgccgg agcgggtgtc gagcacgcgg gtgggtcccg cggtgttgaa caccgatcct
    20641 gtggaggtgt agtagccggt gaggtcggcc agcaggtcaa cggtgcccag gaggttgtag
    20701 aagtcgacct tcccgttcac caccggaacc acgaccaggt tcggaatcgt ctgcttcgcc
    20761 acgaagttga ggttcgagac gcccggccgg ggctgcccgt ccggatagac gctcacgaag
    20821 ccaccggagg tcggcgcgac cgccgtcacg ttcaggacga ccgccgtgac tccggtggcc
    20881 ggcacggcac cgacgcccgc gacctgcagg gcgatgctcg cccccggacc caccggagcc
    20941 ttcgccgcac ccagccccga ccgcgtgtcg agcacccgcg tcggaccggc gctgttgaag
    21001 cgggagccgg tggtcgaggt ggagtagtag ccggtgaggt cggccagcag gttgacgttg
    21061 ccggcgaggt tgtagaagtc gatctttccg ttgatcaccg gaaccacgac gaggttcgcg
    21121 atggtctgct gcggcgagaa gttgaggttc gagacgcccg gccggggctg cccgtccgga
    21181 tagacgctca cgaagccacc ggaggtcggc gcgaccgccg tcacgttcag gacgaccgcc
    21241 gtgactccgg tggccggcac ggcaccgacg cccgcgacct gcagggcgat gctcgccccc
    21301 ggacccaccg gagccttcgc cgcacccagc cccgaccgcg tgtcgagcac ccgcgtcgga
    21361 ccggtcggcg tgtacgtgcc cgtcgggggc ttggccgcct cgacggtggt gacatcactc
    21421 gccttcacga aggcgatgcg gtggttgtag cggatcgggt agtacgtcgt cgtgccgacg
    21481 accagggtgt ggtccccggg cgcgtccatg ttgacgttct gcgcgtagaa gaagtcgctc
    21541 gcgatcggcg cgtcggcgac ataggcctgg ccggccggca tggtgtagct ggtcgccacg
    21601 acctgctgct tggggtcctt gccgacggcg gagaggacgg ccgggtacgc ggactcctcc
    21661 gggtaggagc ggccgtagac cggtacggcg gcgctgccgg cgggggtgac gaccttctgc
    21721 gcggtgcggc tgttggcgac ggcgttctgt ccgccggggt tgaagaacca cgccttctgg
    21781 cccgcgtacc agatcgccgt ccagtcgccc tggacatcgg cgacgatgaa ggtctggccg
    21841 gagaccgcct tgtccgtcca gtcggctccc tggatggtcc ccgtggcccc cttcttggcg
    21901 acgagagcgt ccttgatcaa ggccgcggaa gcggacgggg aggtccgcag atagacgaag
    21961 ttcgccggac gtgccgggca cgggctcgtg gacgtcttgc cgtcgcaacc ggtcaccacg
    22021 ggctggttcg ccgtggtgaa gggcggagcg atggtgatct ccccgccgac gatcggagcg
    22081 ccgttgccgc cgagcggggc gccgagcaga tccatgtagt gcgaccagtc ccagtacgta
    22141 ccggggtcgt agtgcatgcc cgccacgtag tcgtccgtcg ggccggtgac atcgtcgtgg
    22201 ccgatgatgt gctgccggtc gagcgggatg ttgaagcggg ccgccaggta gcgcacgagt
    22261 gccgccgagg actcgtactg cgcctcggtg taccagctcg cgttcgtgag ggcgaagccc
    22321 tcgtgctcga cgccgaggct gtgcatgttc agcaccttgc tgccggcgtg ccacgcctcg
    22381 tccttggtgg gcaccacctg tgacaccagg ccgtccttcg cgcggaccag gtagttcgcg
    22441 ctgacgtagg aggtcgggtt ctggaagatg ttgacggcgg agctgtagtc gctctcggtg
    22501 tcatggatga cgatgtagcg gatcgtctgg ccgtcggccg gccggttggc cttgtcgtag
    22561 ttgccgtaga cggccgggtc cgcggcgttc gtcccctggt aggcggccgg gacgacgtcg
    22621 cacaccaga
//
