GCF_005844435.1 - 6 region(s) - antiSMASH results

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Location: 18,288 - 30,300 nt. (total: 12,013 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carbamoyltransferase

FGQ50_RS05605: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002577.2	0.46	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.44	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000589.5	0.42	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001864.3	0.41	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000590.5	0.40	ribosomal	microcin N	Escherichia coli
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002577.2	0.46	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.44	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000589.5	0.42	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001864.3	0.41	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000590.5	0.40	ribosomal	microcin N	Escherichia coli
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.54 out of 27.78

Confidence: strong

Additional weak hits (2):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.88 out of 36.54

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.53 out of 23.43

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_SPGD01000013.1 - Region 1 - NRPS-like

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Location: 1 - 21,939 nt. (total: 21,939 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

FGQ50_RS06320: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.74 out of 23.79

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.74 out of 26.85

Confidence: medium

Additional weak hits (1):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.37 out of 30.22

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 21939:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGQ50_RS06320: X

AMP-binding (7..383): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HRYVFSVSTTQSQAALAGEVNVYGQSEFHAATAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism

NZ_SPGD01000019.1 - Region 1 - NRPS,NRPS-like

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Location: 5,372 - 43,249 nt. (total: 37,878 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase

FGQ50_RS07860: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: ligase

FGQ50_RS07865: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FGQ50_RS07880: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.67	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.67	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.87 out of 26.33

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.97 out of 25.31

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

Additional weak hits (2):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.96 out of 29.38

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.02 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 5371 - 43249:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - D-Ser - Gly) + (Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 9156 - 43249:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - D-Ser - Gly) + (Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGQ50_RS07865: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (10..374): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: TWETFAISYIESNTTLSGQYNVYGNTECGAATAI
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

FGQ50_RS07880: X - X - Ser - Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (376..748): X

nrpys: Orn, Lys, Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YEVFFDASLHDRGMFCGGEKNCYGPTETTIMSFV
Nearest Stachelhaus code(s):: Thr DAHQFGLIDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1339..1706): X

nrpys: Phe, Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TNQAFDASVYENTLIVAGETNAYGPTEITVCATV
Nearest Stachelhaus code(s):: Tyr DASTIAAVCK (82% 8Å match); Phe DAWTIAAVCK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2296..2678): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFCSGEHNLYGPTEASIDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3698..4078): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: YNMAFDIFGTEGQSLVGGEINIYGPTEGTVWTSM
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (65% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
PerR	Peroxide regulator

NZ_SPGD01000024.1 - Region 1 - T3PKS

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Location: 4,480 - 30,909 nt. (total: 26,430 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

FGQ50_RS08800: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: hydrolase

FGQ50_RS08775: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Isomerases: mutase

FGQ50_RS08715: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase

FGQ50_RS08805: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001080.5	0.39	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.39	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000934.4	0.37	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000526.5	0.33	ribosomal	macedocin	Streptococcus macedonicus
BGC0001078.5	0.32	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0000652.5	0.32	terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0000679.5	0.32	terpene	diazepinomicin	Micromonospora sp. M42
BGC0001079.5	0.32	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001080.5	0.39	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.39	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000934.4	0.37	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000526.5	0.33	ribosomal	macedocin	Streptococcus macedonicus
BGC0001078.5	0.32	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0000652.5	0.32	terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0000679.5	0.32	terpene	diazepinomicin	Micromonospora sp. M42
BGC0001079.5	0.32	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.07 out of 18.46

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.89 out of 23.79

Confidence: medium

Additional weak hits (1):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.02 out of 29.38

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_SPGD01000002.1 - Region 1 - terpene-precursor

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Location: 126,533 - 147,435 nt. (total: 20,903 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

FGQ50_RS01715: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002073.3	0.39	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002694.2	0.38	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0002116.3	0.37	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000410.5	0.37	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002531.3	0.35	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0001870.3	0.34	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.5	0.34	other (other)	vibrioferrin	Vibrio alginolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002073.3	0.39	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002694.2	0.38	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0002116.3	0.37	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000410.5	0.37	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002531.3	0.35	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0001870.3	0.34	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.5	0.34	other (other)	vibrioferrin	Vibrio alginolyticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FGQ50_RS01715: PT_FPPS_like

Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.98 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.76 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.44 out of 30.25

Confidence: medium

Additional weak hits (2):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.57 out of 36.53

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.15 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_SPGD01000003.1 - Region 1 - lanthipeptide-class-ii

Download region SVG

Location: 10,617 - 38,419 nt. (total: 27,803 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FGQ50_RS01910: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase

FGQ50_RS01915: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

FGQ50_RS01925: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.77	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.77	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FGQ50_RS01915

FGQ50_RS01880

Leader:

MQLPNKLYSYQKSTLAYLPRVLNEIKGG

Core:

NSNVKDIFHAISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

Core with dehydrations:

NDhaNVKDIFHAIDhaEELDDPDhbDFLDhaIMDCysLYALNAIEMDhaNEGEVKLCysL

antiSMASH-DB 4.0 matches for FGQ50_RS01880

100.0%

NZ_QRWZ01000002.1and 1 other:

NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide

Lanthipeptides: DWX18_RS02675_lanthipeptide

NSNVKDIFHAISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

78.3%

NZ_BLIS01000009.1and 4 others:

NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS03005_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05635_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03100_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02400_lanthipeptide

Lanthipeptides: GVO03_RS04870_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

76.1%

Lanthipeptides: NQZ98_RS01535_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEV LCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

with 1 more sequence matches

15.2%

NZ_CAKMMP010000011.1:

Lanthipeptides: allorf_219369_219518_lanthipeptide

IFHAISEELDDPTDFLSIMDC

+ +I E+L + T ++S+M+C

VCRSIREDLCEQTWWVSLMNC

FGQ50_RS01890

Leader:

MKFSYNKIWKLLIDKGWTKSELRQKAGI

Core:

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

Core with dehydrations:

DhaDhaDhaDhbIAKLGKGENVDhbDhbDILLKICysIALDCysKIEDIIEIVNDhaK

antiSMASH-DB 4.0 matches for FGQ50_RS01890

100.0%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide

Lanthipeptides: GVO03_RS04860_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

80.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptides: NQZ98_RS01525_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIV

SSSTIAKLGKGENVTTD+LL+ICIALDC IEDI+EI+

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEII

32.5%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

SSSTIAKLGKGE-NVTTDILLKICIALDCKIEDIIEI

S +T++ + G+ N T + L +CIALD K E++

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELFYF

with 4 more sequence matches

17.5%

NZ_BBZK01000004.1:

Lanthipeptides: BGP73_RS05180_lanthipeptide

LLKICIALDCKIEDII

L IC LDC+ D++

LSAICRELDCQPGDLL

17.5%

NZ_CP047936.1:

Lanthipeptides: allorf_0851453_0851611_lanthipeptide

ALDCKIEDIIEIV

AL C + D+IEI+

ALRCFVHDVIEIL

17.4%

NC_009621.1and 4 others:

NZ_CP088111.1 Lanthipeptides: allorf_0786726_0786959_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_6661_6894_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1862_2095_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_06616_06849_lanthipeptide

Lanthipeptides: allorf_1020482_1020715_lanthipeptide

KGENVTTDILLKICIALDC

+GEN+ T L+K + L C

QGENMVTKSLIKRLMMLVC

12.2%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

NVTTDILLKICIALDCKIEDIIE

+ + ++ K+ DC+IED+ +

DPSIELAFKLADHFDCRIEDLFD

MIBiG 4.0 matches for FGQ50_RS01890

10.0%

Lanthipeptide: venezuelin

ILLKICIALDCK

+L +CI + C

LLNTVCIGISCA

FGQ50_RS01930

Leader:

MEQNNLELGKYLESDLLSLTDENVDGG

Core:

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

Core with dehydrations:

DhbDhbPADhbPYDhbPAIGKGVIAVDhbAFVDhaANDhbCysPDhbDhaACysDhbRACys

antiSMASH-DB 4.0 matches for FGQ50_RS01930

100.0%

NZ_QRWZ01000002.1and 3 others:

NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: DWX18_RS02625_lanthipeptide

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

87.2%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

+PATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

SPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

66.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TTPATP TP I +AV+A+VS TCPT+ACTRAC

TTPATPATPVI----VAVSAYVSDKTCPTTACTRAC

with 90 more sequence matches

Only the first 10 are displayed here.

61.1%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

ATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

A+P TP + K +AVTAF+SANTCPT++CTRAC

ASPATPWLVKASVAVTAFISANTCPTTSCTRAC

50.0%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TPAI I V+ F+S NTCP++ACTRAC

TPAIS---ILVSGFISTNTCPSTACTRAC

50.0%

NZ_JALAPU010000003.1and 7 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ VTA++S+NTCPT+ACTRAC

WTPALS----VVTAYISSNTCPTTACTRAC

50.0%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TP IG + V+ FVS++TCPT+ACTRAC

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

46.2%

NZ_CP033054.1and 11 others:

NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide

Lanthipeptides: D9777_RS18840_lanthipeptide

TPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

TPAT T IG T +SA +CPTSACT+ C

TPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

44.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TTPATP +I T V+A+ CPT+ CT C

TTPATPT-------IIGATIAVTASLCPTTKCTSRC

44.4%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ +T ++S+NTCPT+ACTRAC

WTPALS----VITGYISSNTCPTTACTRAC

44.4%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP T A+ VT +SA +CPTSACT C

TPVTAIITALTGTTFTVT--LSAASCPTSACTNLC

44.4%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP AI V + TA VSA TSACT++C

TPVVSAISATVASATA-VSALFTVTSACTKSC

44.4%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP T A+ VT +SA +CPTSACT C

TPVTAILTALTGTTFTVT--LSAASCPTSACTNLC

MIBiG 4.0 matches for FGQ50_RS01930

32.4%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

GVIAVTAFV----SANTCPTSACTRAC

G++A+ A V SA CPT+ CT C

GIVAIQAGVAVGVSAAFCPTTKCTSRC

19.4%

BGC0002110.3 (QKV49894.1):

Linaridin: cypemycin

ATPYTPAIGKGVI

ATP TP + + VI

ATPATPTVAQFVI

16.7%

Lanthipeptide: birimositide

CPTSACTRAC

CPT+ CT C

CPTTKCTSKC

with 1 more sequence matches

13.9%

BGC0002110.3 (QKV49893.1):

Linaridin: cypemycin

TPATP

FGQ50_RS01935

Leader:

MDKHSEVTLENEILFQEFDEDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbLDhbHECysMNWCysK

antiSMASH-DB 4.0 matches for FGQ50_RS01935

100.0%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

90.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGNKG WCT THECM+WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 107 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN GNWCT THECM+WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN GNWCTL+HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN+G WCTLTHECM+WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

86.7%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN+GNWCTL+HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGNKG WCT++HECM+WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN GNWCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN G+WC+L+HECM+WCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

83.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN G+WCT THEC++WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

80.0%

NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

CTTNTFSLSDYWGNKG WCT++ ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN G CT+THECM+WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

MIBiG 4.0 matches for FGQ50_RS01935

66.7%

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

CTTNTFSLS+ GN G WCTLT EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

43.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTLTHECMNWC

+++S GNKG +CTLT ECM C

YNISCRLGNKGAYCTLTVECMPSC

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTHECMNWC

CTL+ EC C

CTLSKECQPNC

Lanthipeptide(s) for FGQ50_RS01925

FGQ50_RS01880

Leader:

MQLPNKLYSYQKSTLAYLPRVLNEIKGG

Core:

NSNVKDIFHAISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

Core with dehydrations:

NDhaNVKDIFHAIDhaEELDDPDhbDFLDhaIMDCysLYALNAIEMDhaNEGEVKLCysL

antiSMASH-DB 4.0 matches for FGQ50_RS01880

100.0%

NZ_QRWZ01000002.1and 1 other:

NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide

Lanthipeptides: DWX18_RS02675_lanthipeptide

NSNVKDIFHAISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

78.3%

NZ_BLIS01000009.1and 4 others:

Lanthipeptides: GVO03_RS04870_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

76.1%

Lanthipeptides: NQZ98_RS01535_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEV LCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

with 1 more sequence matches

15.2%

NZ_CAKMMP010000011.1:

Lanthipeptides: allorf_219369_219518_lanthipeptide

IFHAISEELDDPTDFLSIMDC

+ +I E+L + T ++S+M+C

VCRSIREDLCEQTWWVSLMNC

FGQ50_RS01890

Leader:

MKFSYNKIWKLLIDKGWTKSELRQKAGI

Core:

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

Core with dehydrations:

DhaDhaDhaDhbIAKLGKGENVDhbDhbDILLKICysIALDCysKIEDIIEIVNDhaK

antiSMASH-DB 4.0 matches for FGQ50_RS01890

100.0%

NZ_BLIS01000009.1and 5 others:

Lanthipeptides: GVO03_RS04860_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

80.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptides: NQZ98_RS01525_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIV

SSSTIAKLGKGENVTTD+LL+ICIALDC IEDI+EI+

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEII

32.5%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

SSSTIAKLGKGE-NVTTDILLKICIALDCKIEDIIEI

S +T++ + G+ N T + L +CIALD K E++

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELFYF

with 4 more sequence matches

17.5%

NZ_BBZK01000004.1:

Lanthipeptides: BGP73_RS05180_lanthipeptide

LLKICIALDCKIEDII

L IC LDC+ D++

LSAICRELDCQPGDLL

17.5%

NZ_CP047936.1:

Lanthipeptides: allorf_0851453_0851611_lanthipeptide

ALDCKIEDIIEIV

AL C + D+IEI+

ALRCFVHDVIEIL

17.4%

NC_009621.1and 4 others:

Lanthipeptides: allorf_1020482_1020715_lanthipeptide

KGENVTTDILLKICIALDC

+GEN+ T L+K + L C

QGENMVTKSLIKRLMMLVC

12.2%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

NVTTDILLKICIALDCKIEDIIE

+ + ++ K+ DC+IED+ +

DPSIELAFKLADHFDCRIEDLFD

MIBiG 4.0 matches for FGQ50_RS01890

10.0%

Lanthipeptide: venezuelin

ILLKICIALDCK

+L +CI + C

LLNTVCIGISCA

FGQ50_RS01930

Leader:

MEQNNLELGKYLESDLLSLTDENVDGG

Core:

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

Core with dehydrations:

DhbDhbPADhbPYDhbPAIGKGVIAVDhbAFVDhaANDhbCysPDhbDhaACysDhbRACys

antiSMASH-DB 4.0 matches for FGQ50_RS01930

100.0%

NZ_QRWZ01000002.1and 3 others:

NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: DWX18_RS02625_lanthipeptide

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

87.2%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

+PATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

SPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

66.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TTPATP TP I +AV+A+VS TCPT+ACTRAC

TTPATPATPVI----VAVSAYVSDKTCPTTACTRAC

with 90 more sequence matches

Only the first 10 are displayed here.

61.1%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

ATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

A+P TP + K +AVTAF+SANTCPT++CTRAC

ASPATPWLVKASVAVTAFISANTCPTTSCTRAC

50.0%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TPAI I V+ F+S NTCP++ACTRAC

TPAIS---ILVSGFISTNTCPSTACTRAC

50.0%

NZ_JALAPU010000003.1and 7 others:

Lanthipeptides: MOD17_RS07925_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ VTA++S+NTCPT+ACTRAC

WTPALS----VVTAYISSNTCPTTACTRAC

50.0%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TP IG + V+ FVS++TCPT+ACTRAC

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

46.2%

NZ_CP033054.1and 11 others:

Lanthipeptides: D9777_RS18840_lanthipeptide

TPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

TPAT T IG T +SA +CPTSACT+ C

TPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

44.4%

NZ_CM000721.1and 9 others:

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TTPATP +I T V+A+ CPT+ CT C

TTPATPT-------IIGATIAVTASLCPTTKCTSRC

44.4%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ +T ++S+NTCPT+ACTRAC

WTPALS----VITGYISSNTCPTTACTRAC

44.4%

NZ_CP047645.1and 5 others:

Lanthipeptides: GSN02_RS17435_lanthipeptide

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP T A+ VT +SA +CPTSACT C

TPVTAIITALTGTTFTVT--LSAASCPTSACTNLC

44.4%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP AI V + TA VSA TSACT++C

TPVVSAISATVASATA-VSALFTVTSACTKSC

44.4%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP T A+ VT +SA +CPTSACT C

TPVTAILTALTGTTFTVT--LSAASCPTSACTNLC

MIBiG 4.0 matches for FGQ50_RS01930

32.4%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

GVIAVTAFV----SANTCPTSACTRAC

G++A+ A V SA CPT+ CT C

GIVAIQAGVAVGVSAAFCPTTKCTSRC

19.4%

BGC0002110.3 (QKV49894.1):

Linaridin: cypemycin

ATPYTPAIGKGVI

ATP TP + + VI

ATPATPTVAQFVI

16.7%

Lanthipeptide: birimositide

CPTSACTRAC

CPT+ CT C

CPTTKCTSKC

with 1 more sequence matches

13.9%