LOCUS       NZ_SPGD01000003        27803 bp    DNA     linear   CON 20-MAY-2024
DEFINITION  Streptococcus anginosus strain 1001175st1_H11
            NODE_3_length_122079_cov_72.8988, whole genome shotgun sequence.
ACCESSION   NZ_SPGD01000003
VERSION     NZ_SPGD01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus anginosus
  ORGANISM  Streptococcus anginosus
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus; Streptococcus anginosus group.
REFERENCE   1  (bases 1 to 122079)
  AUTHORS   Yang,C., Faith,J. and Aggarwala,V.
  TITLE     Strain-level differences in gut microbiome composition determine
            fecal IgA levels and are modifiable by gut microbiota manipulation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 122079)
  AUTHORS   Yang,C., Faith,J. and Aggarwala,V.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Genetics and Genomic Sciences, Icahn School
            of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 85.9707156971x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005844435.1-RS_2024_05_20
            Annotation Date                   :: 05/20/2024 01:50:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,133
            CDSs (total)                      :: 2,088
            Genes (coding)                    :: 1,937
            CDSs (with protein)               :: 1,937
            Genes (RNA)                       :: 45
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 39
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 151
            CDSs (without protein)            :: 151
            Pseudo Genes (ambiguous residues) :: 0 of 151
            Pseudo Genes (frameshifted)       :: 73 of 151
            Pseudo Genes (incomplete)         :: 73 of 151
            Pseudo Genes (internal stop)      :: 52 of 151
            Pseudo Genes (multiple problems)  :: 40 of 151
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:21:34
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10616
            Orig. end                         :: 38419
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SPGD01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27803
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..27803
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27803
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17803](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17803)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    265..274
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.05"
                     /tool="antismash"
     gene            complement(1874..2416)
                     /locus_tag="FGQ50_RS01865"
     CDS             complement(1874..2416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646663.1"
                     /locus_tag="FGQ50_RS01865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017646663.1"
                     /transl_table=11
                     /translation="MSKINKNSLYFHLITQDYFDTYQYLDEFQEDNARGHGVMVLDINN
                     QLIAIPLRSGLPEHLRNASHLFPYTTYRRHDGRICLKALDFSKLTIIEEKYIDNSRIYH
                     FKNPNEKIFYLRNSNRIFSRVKNYVNKYIEICSKIEKGETVTFRTLNPYRFSTLRNFHD
                     ELGIAISKEDFINQLRK"
     gene            complement(2578..3174)
                     /locus_tag="FGQ50_RS01870"
     CDS             complement(2578..3174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648121.1"
                     /locus_tag="FGQ50_RS01870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017646662.1"
                     /transl_table=11
                     /translation="MTNKDNIYNECQKQECSLEVGLLEGQMLAPMLVENQQVIEDMRLK
                     RETLRSWRPAKQLNVYVLVAFIPVFPEEYAKTERIYKDAVENFLNEFRTRKSKNIEEII
                     SYEAWIDMDESTLYSSTEELEEFMFAEMLQDLLEKVRQADKDLYDITLGLLAKEFDESI
                     EDVFARIGVKRSTGFYRLPKARALVAALLKKFNPK"
     gene            3607..4725
                     /locus_tag="FGQ50_RS01875"
     CDS             3607..4725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000347290.1"
                     /locus_tag="FGQ50_RS01875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-three component system protein"
                     /protein_id="WP_050885203.1"
                     /transl_table=11
                     /translation="MDFPTYFRILKKYLGDGATIPEFFRELIEMITEDDAEEIISASGI
                     TSEKTDNTLVSYAKRSFSKKMANQLLYRVNSANMTESIESRPDETIQLLTNEFNSYYPD
                     ITAENASQRIPEIFVDFIREKAGMGISTTAQKATFVNQSNQLKKQYGQFLLAESNNCCA
                     FPGCDKSLILTRGDLASENYEVSAIEKDKDAEPLNLIALCPDCFLTYQAESRKKIVTAL
                     KNVKKILVSAHNSHRPISELKLDNGIVAVLTSLNKLKYDEYDISYDPKKLTDKISPENN
                     RTLYQMVKNQVIDNYLTIQKIIVNLDKQGKIDYEEIQYQMRSMYKKLKASKHDNLAIFN
                     TISEKIHKATLQDTYFCQAIVSYFIQKCEVLE"
     gene            4725..4949
                     /locus_tag="FGQ50_RS01880"
     CDS             4725..4949
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176804.1"
                     /locus_tag="FGQ50_RS01880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-three component system middle component 7"
                     /protein_id="WP_050885204.1"
                     /transl_table=11
                     /translation="MQLPNKLYSYQKSTLAYLPRVLNEIKGGNSNVKDIFHAISEELDD
                     PTDFLSIMDCLYALNAIEMSNEGEVKLCL"
     CDS_motif       4725..4808
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MQLPNKLYSYQKSTLAYLPRVLNEIKGG"
                     /locus_tag="FGQ50_RS01880_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4809..4949
                     /prepeptide="core"
                     /locus_tag="FGQ50_RS01880_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.00"
                     /molecular_weight="5071.7"
                     /monoisotopic_mass="5068.4"
                     /core_sequence="NSNVKDIFHAISEELDDPTDFLSIMDCLYALNAIEMSNEGEVK
                     LCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQLPNKLYSYQKSTLAYLPRVLNEIKGG"
                     /leader_location="[4724:4808](+)"
                     /alternative_weights="5089.7"
                     /alternative_weights="5107.7"
                     /alternative_weights="5125.7"
     gene            4940..6598
                     /locus_tag="FGQ50_RS01885"
     CDS             4940..6598
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904398.1"
                     /locus_tag="FGQ50_RS01885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2326 domain-containing protein"
                     /protein_id="WP_118138834.1"
                     /transl_table=11
                     /translation="MLIEMWSPVFKKHGEIREPIRFHHGLNVIMGMDLADNSIGKSSSL
                     LAIDFIFGGNSYLKSIAVKKLGDHPIYFCFQFEKKFYFARDTAKPDIITYCNDDYSPTG
                     ETMPLEIFLDKLKKRYHLDSPDLSFRLAMSGFFRIAGKNNQNTDFPLQVYSSQKSSESI
                     TTLIQLFNLYDNIARYKERLKDKSDQLTTFRNARKYAFISNLVGGKKQFEANVSEIKRL
                     EYDLSHLQDTQQDKIDSGDIEKNQQKIQLRNTKLELENSLRDKQRRLKLLDISIEFGLY
                     PTESDLTELQQYFPDTNLKKLYEVEAYHKKLANILDSEFSIERESLIAEIDELESQLTI
                     LNQELQELGNIPNLSSEYLENYSKLTATINALKEQNEAYLKESSLSKEKSEADADLKRS
                     TEDILLDLEVKINSKMREFNNILYPDIRKAPQINLKAHNSYSFYTPDDDGTGTKFKGMI
                     LFDLTMLYLTNLPALAHDSLLLSNISYQATEALLKLYDQSKSLNKQVFLAFDKASSYSP
                     EANQLLSENTVLRLSSNGNELYGISWNKGENSDEV"
     gene            6588..6794
                     /locus_tag="FGQ50_RS01890"
     CDS             6588..6794
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985621.1"
                     /locus_tag="FGQ50_RS01890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_118138833.1"
                     /transl_table=11
                     /translation="MKFSYNKIWKLLIDKGWTKSELRQKAGISSSTIAKLGKGENVTTD
                     ILLKICIALDCKIEDIIEIVNSK"
     CDS_motif       6588..6671
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKFSYNKIWKLLIDKGWTKSELRQKAGI"
                     /locus_tag="FGQ50_RS01890_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6672..6794
                     /prepeptide="core"
                     /locus_tag="FGQ50_RS01890_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="4163.9"
                     /monoisotopic_mass="4161.3"
                     /core_sequence="SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKFSYNKIWKLLIDKGWTKSELRQKAGI"
                     /leader_location="[6587:6671](+)"
                     /alternative_weights="4181.9"
                     /alternative_weights="4199.9"
                     /alternative_weights="4217.9"
                     /alternative_weights="4235.9"
                     /alternative_weights="4254.0"
     gene            complement(6908..>7149)
                     /locus_tag="FGQ50_RS10825"
                     /pseudo=""
     CDS             complement(6908..>7149)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407401.1"
                     /locus_tag="FGQ50_RS10825"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="macrolide ABC transporter permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="LSEFVNKHLSSKRLMIFLALYSLMLMLATPLYFMFHNVIIRTFSR
                     "
     misc_feature    complement(7147..7162)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.43"
                     /tool="antismash"
     gene            complement(7166..7894)
                     /locus_tag="FGQ50_RS01900"
     CDS             complement(7166..7894)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FGQ50_RS01900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ABC transporter permease"
                     /protein_id="WP_138284006.1"
                     /transl_table=11
                     /translation="MKFNKRLYIKNCLKELITSGIIIIGVIVAVIPPVILMYYIINYGS
                     NSFYIKHISNFFCIFGLYIGVLSPLYFINRDFSMDTITLVCNTKENRIAYLNANVLLAF
                     FLSLFYSSIGVATVLIANYLGVTGDLTVNFIIGFFCNLTITIVFYYLFSYLLFSFFIKS
                     NVVFSFLTLLLLFIPNIISNILYSTQNELLNNLFEKIPMYFLPIYAGSNIMEVSQYIIS
                     ILSICILYTLSMKKTLNLRF"
     gene            complement(7899..8753)
                     /locus_tag="FGQ50_RS01905"
     CDS             complement(7899..8753)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018366183.1"
                     /locus_tag="FGQ50_RS01905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_065361263.1"
                     /transl_table=11
                     /translation="MELYNVVKKFKNHVVLNDISFEINKGEIVGLVGKNGAGKSTLMKI
                     ISKLDTNFEGKIDEVGRLGYFIESPKLVTNRTGLWNLKYFSYIFGNKFLIEDYFDFYQS
                     IEIIDFLKQKVKKYSLGMKQKLGVLIALLNNPDYVILDEPTNGMDIDSSIVFLQELKKI
                     VKEKNIGVFISSHKLEDIELICDRIIFLNNGKLEKLNSREYKNRIIHKLIFRDKNDVDL
                     FLKNQNIGIITESQDDFIKIETSCSYSELMDLINKLNISLLDYSYEQKTLRDIYIDKII
                     KGD"
     gene            complement(8920..10035)
                     /locus_tag="FGQ50_RS01910"
     CDS             complement(8920..10035)
                     /NRPS_PKS="Domain: PKS_ER (45-229). E-value: 1.3e-10.
                     Score: 32.8. Matches aSDomain:
                     nrpspksdomains_FGQ50_RS01910_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012335.4"
                     /locus_tag="FGQ50_RS01910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_118138831.1"
                     /transl_table=11
                     /translation="MLSVVALNPKHDIINKAINVVYINFGNIQIPFGLIEFEQPVFDLN
                     NPKNDDYLLIKVNSFSCNYRDKAILVNNFEQLLRLGKPFLPFGSEFSATIVLKGKNVDE
                     FGIGDKVIPNCTYEGVTNDNVVPGVTTNFASLGWLRIRREKLIKQPHELSDLEAACFSL
                     GAQTAYSMIRKSGILEKQNKKAVVFSSRSVTSLFIIQLLNYFGIDLVCCSSSEWSKEEL
                     DSIGIKKVVSVDGIEEYLDSFSHVFDPYFDLNFSRAVSLLGNGGKYVFCGFLNQHPVLS
                     KEDDKTLNTEEIFNSLKLVIVKNISLIGNCLGSQEDLNKVIEIYGSEISPTIDSEYNLG
                     QLEEFLTRSFFDKNKLGKCVIDYSREGVTYV"
     aSDomain        complement(9349..9900)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGQ50_RS01910_PKS_ER.1"
                     /evalue="1.30E-10"
                     /label="FGQ50_RS01910_PKS_ER.1"
                     /locus_tag="FGQ50_RS01910"
                     /protein_end="229"
                     /protein_start="45"
                     /score="32.8"
                     /tool="antismash"
                     /translation="NPKNDDYLLIKVNSFSCNYRDKAILVNNFEQLLRLGKPFLPFGSE
                     FSATIVLKGKNVDEFGIGDKVIPNCTYEGVTNDNVVPGVTTNFASLGWLRIRREKLIKQ
                     PHELSDLEAACFSLGAQTAYSMIRKSGILEKQNKKAVVFSSRSVTSLFIIQLLNYFGID
                     LVCCSSSEWSKEELDSIGIKK"
     gene            complement(10001..12787)
                     /locus_tag="FGQ50_RS01915"
     CDS             complement(10001..12787)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024964.4"
                     /locus_tag="FGQ50_RS01915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4135 domain-containing protein"
                     /protein_id="WP_118138830.1"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-68, bitscore:
                     224.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-27, bitscore: 89.6,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISESSKVIESVINYFESDINKAKELLISKINQSNGGDKIIENFI
                     DVLYDLIAKQAWRIINKTFVYEFHEFRKQKGLPISKTSSLAYEMFLSEMNKDVIGKWLK
                     KYTVLHGILQDSILNSCKFITEVFYYYAEDKSLLIDRGFLGREAQINKITLLDSDPHNN
                     GKIVLLFEDTDCRKFIFKNRDFKIDNLINDIFKTLFLNAQKNMESPIPQNIIRDGYGWQ
                     KFVEQVPVIRANVGVSFYNLGYYSVLFSVLGASDLHDENLIFRGEVPYFIDLETALHPR
                     LNSTEQSLIGELQNSITKSIAHTTIIPSKLLNNSYNYLIGAINTPYPQETEKMVFSFKN
                     LGTDAIDIAKEKVVLDRLATPLSCTDGKIIDPVNYYDDFLSGYKSGFIDIMNNKTMISK
                     KVESFKGDIRVVLRPTAQYFLIMDACLYPENLIDYSSAKKILHYLKPISFIKDKTIAKM
                     IYDEECKSLLQGDIPYFKVESDSLNLVINSNTYKRVYSVSAITNALENLKYLSDSQLLF
                     DYRLISEGFSEIKIRNSKKGNVNRDNSKMYIDLLRDLKNGNFEKILDWWKAQSVLYEMN
                     NTKYRAWHNGSYGELPALYSTPTLISFHDIGGVEIMLESLLLAKGTSNSRVIFEEARNG
                     LIKLRDEVYAGDSGDYHSIIAGEESVDFILSKSDKQVRNLELKVKNSEIPIGDVFNGKL
                     GIYLVLASYSRTCLDTMVQGEIELANSSSDYSKFGLAHGKLGELWTKFRIYAKLDLNKE
                     CMRIYSETLKCYKNGKILPGWCNGYSGLLMVLVEMSKVLNIKIDYFELALKCVDLPENA
                     SIDLSVCHGTSGVIQSLLFCYIVTKDKRYIELADSYWNLVYKKAQSDGFYIGESNREYL
                     LGYMMGWSGVIDTILLLNLVKDGRQHWIPLNLSTIDYQEQLKKETFNVIGCSVKSKA"
     gene            complement(12784..14925)
                     /locus_tag="FGQ50_RS01920"
     CDS             complement(12784..14925)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016615515.1"
                     /locus_tag="FGQ50_RS01920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_230318986.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-36, bitscore:
                     118.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKKLIPTLQIAQTECGLCCVRTILEYYGFDISITELRQIEEPGR
                     DGLSTKQLKKLLQKFNLTSNTYKINNPNAFKVIDFPVIAFWKGYHFVCIEKIENNHAFI
                     MDPSIGRVKIDLKDFFENFSEIIIASYPNETFRKRKKSFAKRYNYRKLIPSDILNNYLG
                     LIITSVLVIAINISIPVLTQLLIDSVQTNNYDFRYIILSIVFLGIVSGTVFYFKSVLSI
                     TLMKNFSWHLLSTAFNRILSLPSKYFTVRSPGEIVYRLNSLTRIQDLFGTSLIQLFLDI
                     ISLFAILIYLSGVSIILTGVELLFILLLFTLLINLQPKIQSTSDNELHQASLAQSIQLD
                     AIVSINNIKLGGYKEAYKEDWASKYKKSLDYTAERMNIQQSWIGTILGMVSAFVPLVIL
                     SMALFQFSLGRLSLGESIATQTVTSLLYNYANSIFTTFSNFSVLNRYVDLAEDIYEYPI
                     ENSGDIKYQIFKDELVLDNVSFSYSGNNIYALRSINLKIKKGETIALVGESGSGKSTLG
                     KIISSLFMPTIGTIYLDGISYKDYELDSFRNRIGYIPQESYLHNRSIIDNIALGCETER
                     DEIIKKCKNIPFLDFINNLPMGYNTQISEMGGNLSGGQRQRIQIAKILIKQPELLIMDE
                     ATSSLDNVSQKYVYDELNVMNCTKIIIAHRLETILNADKIIVLESGKISQVGTHDQLIT
                     EAGGLYSKLFTAENLENKK"
     gene            complement(14882..17803)
                     /gene="lanM"
                     /locus_tag="FGQ50_RS01925"
     CDS             complement(14882..17803)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="FGQ50_RS01925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_138284011.1"
                     /sec_met_domain="DUF4135 (E-value: 4.8e-65, bitscore:
                     212.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.4e-43, bitscore:
                     141.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGYDKDIYPELKSESEFNEYILPIIEGIKHLTITGEIVSQSKND
                     FINIEETYPYHNSCLFFVDNIWKKLWNDKLNNLLFDSEDFKEAICESLAQVAFTYFIRC
                     FANQIKEYSTNTDIKKNYKEYSRFLIDNCFKNFSSEYPVIWYRCNKLVINKVNYIIIVL
                     NTLTKSRDKIQNKFKISKQLRVKNILMDGDSHNCGKTVSTIIFENGEKLIFKPRTVDGE
                     YGYAKLVNELNMAFKTNFLAVDTLKVGKYGFCSFVEIDDSSIDMVKAGKLACLLYLLNA
                     TDMHYSNIYWTKEGPIPIDLETLFHVPRLKKGLEESQKSAYKYIEQSVYSTGVLPINLV
                     SKNGTVDVGFTGVRNSNSIGPIKSIELLDGFTSNIRFIWGKYPSTTNMKNNISENLQIF
                     QNCDEVSKGFSEMYELVFNNKEWFLNTVSKIFSNSKVRYIHNMTYRYEQILRTLTSTKA
                     SKSESLSKSILSRLGVLSLTCEKPIIISECQQIWNGDVPYFTANYSENYIYDYDEKIIA
                     RTNSSPKSNFEDKIKSLSIKDLNEQLKIIKLAFVAKVQDPHGENAEAFKLKNSLKTSNE
                     IIKLLSDKLMNSVYDDKYEHLPKTWIGPVSTHTTNGWTPGVLGYDMYGGRTGIALVLAL
                     AGTKLGETRYSDLAFQIFEAYAKILESNVYETRSILSSGIGLYSGFPSVIWGLYEASHI
                     FKEEKWKKIAIDSWKIIDEEICSVKSGFFDMMSGNSATIIMRLKMDKEFQLNNYQIELF
                     ISEALKVLENRNERTTSGLVHGISHLIWFFSIIYQTYPTAAVRELINDCLKILKENYYS
                     EKEEINIYERTDYQSDSWCNGVSGVLLAYYEGFKAGIVDKKDVSLLLQQLKRLRITTLP
                     VYCHGILGILEVLNYMKSDFLEDVSSILFMADFKGDFSNVIYHYFKSEKGRYTLSPGFM
                     SGISGAVYYLCKLNIDFKISPITLEKHYEDEKKTNSNTANCTN"
     gene            complement(17820..18011)
                     /locus_tag="FGQ50_RS01930"
     CDS             complement(17820..18011)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="FGQ50_RS01930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_050197452.1"
                     /transl_table=11
                     /translation="MEQNNLELGKYLESDLLSLTDENVDGGTTPATPYTPAIGKGVIAV
                     TAFVSANTCPTSACTRAC"
     CDS_motif       complement(17931..18011)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEQNNLELGKYLESDLLSLTDENVDGG"
                     /locus_tag="FGQ50_RS01930_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17820..17930)
                     /prepeptide="core"
                     /locus_tag="FGQ50_RS01930_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="3362.9"
                     /monoisotopic_mass="3360.7"
                     /core_sequence="TTPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEQNNLELGKYLESDLLSLTDENVDGG"
                     /leader_location="[17930:18011](-)"
                     /alternative_weights="3380.9"
                     /alternative_weights="3398.9"
                     /alternative_weights="3416.9"
                     /alternative_weights="3434.9"
                     /alternative_weights="3453.0"
                     /alternative_weights="3471.0"
                     /alternative_weights="3489.0"
     gene            complement(18026..18193)
                     /locus_tag="FGQ50_RS01935"
     CDS             complement(18026..18193)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010890685.1"
                     /locus_tag="FGQ50_RS01935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_050197451.1"
                     /sec_met_domain="mature_ha (E-value: 2.7e-15, bitscore:
                     48.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKHSEVTLENEILFQEFDEDVFGACTTNTFSLSDYWGNKGNWCT
                     LTHECMNWCK"
     CDS_motif       complement(18119..18193)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDKHSEVTLENEILFQEFDEDVFGA"
                     /locus_tag="FGQ50_RS01935_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18026..18118)
                     /prepeptide="core"
                     /locus_tag="FGQ50_RS01935_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="3418.8"
                     /monoisotopic_mass="3416.5"
                     /core_sequence="CTTNTFSLSDYWGNKGNWCTLTHECMNWCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDKHSEVTLENEILFQEFDEDVFGA"
                     /leader_location="[18118:18193](-)"
                     /alternative_weights="3436.8"
                     /alternative_weights="3454.8"
                     /alternative_weights="3472.9"
     misc_feature    complement(18147..18161)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 24.71"
                     /tool="antismash"
     misc_feature    18153..18167
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.47"
                     /tool="antismash"
     misc_feature    complement(18403..18417)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.18"
                     /tool="antismash"
     misc_feature    complement(18404..18419)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.91"
                     /tool="antismash"
     gene            18542..19393
                     /locus_tag="FGQ50_RS01945"
     CDS             18542..19393
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399479.1"
                     /locus_tag="FGQ50_RS01945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rgg/GadR/MutR family transcriptional regulator"
                     /protein_id="WP_138284014.1"
                     /sec_met_domain="TIGR01716 (E-value: 7.1e-63, bitscore:
                     204.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKLGITLRKVRKGKQISLCSVADEHLSKSQISRFERGESEISC
                     IRLINILDKLHVTLDEFLILHNEDYTNGESFANLVQYIRKQYSSQSINNIACLLYDTSN
                     YTLNSLEKTMVKSILHTMDSNVIPSDEELLQLTDYLFKVEKWGYYEIILLGNCVRTINY
                     NSYFLLTKEMLNNYIYSSLNKTNKRIVTQLAINCLILSIDKEKFSNCSYLIDEIKALLD
                     NEVNFYEQTVFLYATGYFEFKRQSGTGIEKMKQAIQVLDILGEDKLKLHYTSHFDKLIK
                     NK"
     gene            complement(19643..20275)
                     /locus_tag="FGQ50_RS01950"
     CDS             complement(19643..20275)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000312620.1"
                     /locus_tag="FGQ50_RS01950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_118138826.1"
                     /transl_table=11
                     /translation="MAWFEYLTDSLKKFFLKKSISDFENETENEEEGYDPRFNDTTLEE
                     RGIKIKTYYENWENQTFDSLLEEDGCVELELLINDNAISESFSFRNIGINYSVTKTADF
                     NFRYRSISVLPKYRERGVCSYLLLKSIIVVLEALENKDVEFSLVNTVKIEIGDKFSIYD
                     SILTEKIPNENMQYRVFLSENRDTDLAQLREMYNSKLEKMTTNLKFA"
     gene            complement(20292..21056)
                     /locus_tag="FGQ50_RS01955"
     CDS             complement(20292..21056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001126653.1"
                     /locus_tag="FGQ50_RS01955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_118138825.1"
                     /transl_table=11
                     /translation="MPKSFDEFYFCTADEIEDIETLNDYFIKHKNLGIYHDNMFCPECR
                     QAELSYVPKTSQRRAHLKRKTSSKHTNWCSYQFDYASKKYIEEYFKNLRDDQIKDKLDA
                     MMRSLFFKKEYLPQTPVNLGDSSDENPLVLTRKVERQVHHKTLRRKSIEKWLDKELEDE
                     LHLFYGKVRLSISEWHNEQGYTLYFLNIFCKASNREWKKKASIYLGNKVLLKVEEDADY
                     YLVAIGHLDFSKGFPPKLKLASRQALSIEKVV"
     gene            complement(21365..24898)
                     /gene="smc"
                     /locus_tag="FGQ50_RS01960"
     CDS             complement(21365..24898)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="smc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002931064.1"
                     /locus_tag="FGQ50_RS01960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chromosome segregation protein SMC"
                     /protein_id="WP_024051856.1"
                     /transl_table=11
                     /translation="MYLKEIEIQGFKSFADKTKVIFDQGVTAVVGPNGSGKSNITESLR
                     WALGESSVKSLRGGKMPDVIFAGTETRKPLNYASVVVVLDNKDRFIQQAADEIRVERHI
                     YRSGDSEYKIDGKKVRLRDIHDLFMDTGLGRDSFSIISQGKVEEIFNSKPEERRAIFEE
                     AAGVLKYKTRRKETESKLSQTQDNLDRLEDIIYELDSQVKPLEKQATTAKQFLKLDEER
                     RALYLGVLIAQIKGNKTQLNDTEERLVGIQQSLSAYYSKRDQLEQENALLKEKRHDLQK
                     QMADDQVSLLELTRLISDLERQIEVSKLESSQAANSRKENEERLKGLTEKLEAVQTEWQ
                     GKDEQLIDFDVKLERNQQAIHKLEAEIEAFSDDPDQMIEKLRAEFVQLMQEEADLSNDL
                     TALESRLANELQLSESKQVEFAKLKENLKNLQINEQSQLEDLATARQSVQQLLTDYQAQ
                     LKQVQTVKTNYQQNQTAMFDLMDDVKNKKARVGSLEAILKNHSHFYAGVKSVLQEAECL
                     GGIIGAVSEKLSFDSHYQTALEIALGASSQHIIVEDEQAATRAIEFLKRNRTGRATFLP
                     LTTIKARHLPDHHQGSIEKSTGFLGLASSLVRYDKSLEHIFQNLLGTTAIFDTVENARA
                     AARKVRYQVRIVTLDGTELRTGGSYAGGANRNNNTIFIKPELDALQMELSEKNATLAEQ
                     EKQVEDLHTQLSQANSLLEEIKVSGEEARLAEQKAQMAYEQTHKQVEDLSELLVLQERE
                     LSREVLPDMAEQKEKLVNRLAEIEQDKSETEAEIEQIKSDKDAVQARLDKLTARLSELR
                     LARTELTGHQRYVQTDLTRLSNEKSELDKGISTLQFLMEQKEENASKVDIAVLEEQLTQ
                     AIQEKTTLNQATIRRQFELDDLEGQAEDLTSHLEQARQQNEDLIRKQAKAEAEKDKIAD
                     VLRRLLTNLTDDYQISFDEASKQARPLENLTVSETKVKDLEKVIRALGPVNLDAVEQFE
                     EVSQRLHFLNTQRDDVLSAKNLLLETIEEMNDEVKERFKSTFEAIRESFKVTFRQMFGG
                     GSADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKALSALALLFSIIRVKTIPFV
                     ILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGTMSAADSIYGVTMQESGVSKI
                     VSVKLKDLESM"
     gene            complement(24889..25587)
                     /gene="rnc"
                     /locus_tag="FGQ50_RS01965"
     CDS             complement(24889..25587)
                     /EC_number="3.1.26.3"
                     /GO_function="GO:0004525 - ribonuclease III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rnc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003027666.1"
                     /locus_tag="FGQ50_RS01965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease III"
                     /protein_id="WP_003025140.1"
                     /transl_table=11
                     /translation="MRDLHKVLSQQFGIVFQDEKLLETAFTHTSYANEHRLLNISHNER
                     LEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRSTIVREESLAGFSRDCQFDQFIKLGR
                     GEEKSGGRNRDTILGDLFEAFLGALLLDKGVEAVKNFLYQVMIPKVEVGDFEQVVDYKT
                     KLQELLQVNGDVEIVYQVISESGPAHAKEFAVAVSVDGRTVGQGQGRSKKLAEQEAAKN
                     AFEKESHSCI"
     CDS             25675..25830
                     /gene="allorf_036291_036446"
                     /locus_tag="allorf_036291_036446"
                     /protein_id="allorf_036291_036446"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MELESKLRGSKSSSRAFEVAGVINEVSNKEYSKVGKSFAFLLCHL
                     SQSPEL"
     CDS_motif       25675..25701
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELESKLRG"
                     /locus_tag="allorf_036291_036446_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       25702..25830
                     /prepeptide="core"
                     /locus_tag="allorf_036291_036446_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="4412.9"
                     /monoisotopic_mass="4410.3"
                     /core_sequence="SKSSSRAFEVAGVINEVSNKEYSKVGKSFAFLLCHLSQSPEL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELESKLRG"
                     /leader_location="[25674:25701](+)"
                     /alternative_weights="4431.0"
                     /alternative_weights="4449.0"
                     /alternative_weights="4467.0"
                     /alternative_weights="4485.0"
                     /alternative_weights="4503.0"
                     /alternative_weights="4521.1"
                     /alternative_weights="4539.1"
                     /alternative_weights="4557.1"
     CDS             complement(25711..25806)
                     /gene="allorf_036327_036422"
                     /locus_tag="allorf_036327_036422"
                     /protein_id="allorf_036327_036422"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAKKESETFANLAVLFVADFVDYTCNFKSST"
     CDS_motif       complement(25753..25806)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAKKESETFANLAVLFVA"
                     /locus_tag="allorf_036327_036422_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(25711..25752)
                     /prepeptide="core"
                     /locus_tag="allorf_036327_036422_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="1454.5"
                     /monoisotopic_mass="1453.6"
                     /core_sequence="DFVDYTCNFKSST"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKKESETFANLAVLFVA"
                     /leader_location="[25752:25806](-)"
                     /alternative_weights="1472.6"
                     /alternative_weights="1490.6"
                     /alternative_weights="1508.6"
     gene            complement(25968..26282)
                     /locus_tag="FGQ50_RS01970"
                     /pseudo=""
     CDS             complement(25968..26282)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211119.1"
                     /locus_tag="FGQ50_RS01970"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="YbaN family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAFTALGAALVEAFLLLLSVTCFLRSSKRFE"
     gene            complement(26316..27119)
                     /locus_tag="FGQ50_RS01975"
     CDS             complement(26316..27119)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025145.1"
                     /locus_tag="FGQ50_RS01975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_024051857.1"
                     /transl_table=11
                     /translation="MNEKGFKYSILASGSTGNCFYLETPKKKLLIDAGLSGKKITSLLS
                     EIDRKPEELDAILVTHEHKDHIHGVGILARKYHLDIYANQATWNAMEVALGKIDVSQKH
                     IFEMGKTKTFGDIDIESFGVSHDAVAPQFYRLMKDDKSFVLLTDTGYVSDRMAGIIENA
                     DGYLIESNHDIEILRSGAYPWSLKQRILSDQGHLSNDDGAETMIRTLGYRTKKIYLGHL
                     SKENNTKELAHITMVNQLEQTDLAVEHDFHICDTSPDTATPLTDI"
ORIGIN
        1 tatgacttaa caaaggaaga acttcctgat gaaatcctac aagcattggt agatgacacc
       61 atcatcaagt gggcatttaa tgccagcttt gaacgcatct gtctgtctaa ctggctcaag
      121 aaacatcacc cagaattact atccgaaggt ttcctatctc caaactcatg gcgatgcagt
      181 atggtttggt cagcatatct tggtctgcca ctctcacttg aaggagtcgg aactgtcctc
      241 aagctcaaga accaaaagtt aaaggaaggc ggagatttaa ttcgttactt ctgccttcct
      301 tgtaaaccaa ccaaggttaa cggtggacga acacgaaact ttcccaatca cgcgcccgac
      361 aagtggtctg ctttcattga ttacaataag cgtgacgttg aggtagagtt agccatcaaa
      421 gagaaactcc gtaactaccc tgttccagtc tttgtttggg aggaatacca tcaagaccaa
      481 atcatcaacg accgtgggat tggtattgat gtggactttg tcaatgcagc tattgccatt
      541 gacggggaaa gtaagactaa aatccaagaa gaattgagaa aactaactag acttgataat
      601 cccaactccg ttcttcagat gattggttgg ttaagagaac acggagtgac cactgattcc
      661 ctcgataaga aatctgtaaa aaaactcctc aaaactgtcg atgagaaaac tgcacaagtt
      721 ctcaaacttc ggcagcaagc agccaaatcc agcgtctcca aataccaagc aatgatgaac
      781 tgtgtctgta aagatggacg tgctagagga atgttccaat tctatggagc aaaccgtact
      841 gggcgctggg ctggtcgttt ggttcagttg caaaaccttc cacagaacca tcttcctgac
      901 cttgaggaag ctagaaaact tttcaaaact ggtgacctag aagctactga gctactttat
      961 aacacgcagt atactttatc tcaacttatc cgaactgcat ttgtcccaag cgatagaaaa
     1021 aaattcatcg tctgtgattt ctctgccatc gaggcgcgtg ttctgtctca tcttgcagga
     1081 gagacatggc gaagcagggt ctttgaaaaa ggaaaagaca tctactgcat gtctgcgtca
     1141 cagatgttcg gagtacccgt tgagaaacat gggcaaaacg ctgacctgcg tcaaaaaggg
     1201 aagattgcgg agttggcttg tggatatggc ggagcagttg gtgctcttaa agcaatgggc
     1261 gccattgata tgggacttga ggaacaagaa ctccaaccac tagtggattc ttggcgacaa
     1321 gccaatccca gcatcgtcct tttttggtgg gatgtggata gggctgtgaa aactgccgtc
     1381 aaagaacaaa tccaaaccga aactcacggc attcagttcg aagtcagaaa tgggatgtta
     1441 tttatcactc tcccttctgg tcgaaaactt gcctacgtca aacccaagat gggtgagaac
     1501 caatttggtg gagagtctgt tacctatgaa ggtacaggaa ctgctaaaca ttgggagcga
     1561 cttgaaagct atggaccaaa gtttgtcgag aacattgtcc aggccattag ccgtgatatt
     1621 cttgcctact cgatgagaca acttagtgag ttcaagattg tcggtcatgt ccatgatgaa
     1681 gtcatcattg agtgtgatca agaccaagac cttgaagaaa tttcaacctt gatggggatt
     1741 gcaccagact ggatgtctga cattaacctc cgagctgatg gttatgaatg ttccttttat
     1801 cagaaggact agacacacaa aaaaacggtt cactactaat tcaggtagtg aaccatttta
     1861 tatgtgataa aaactatttc cttaattgat tgatgaaatc ttccttggaa attgctatac
     1921 ccaattcatc atgaaagttg cgtagagtgc taaatcggta tgggttcaat gtcctaaaag
     1981 tgacagtttc tcccttttca atctttgaac aaatctcaat atacttattt acgtaattct
     2041 taactcgtga gaaaatacga tttgaatttc ttagataaaa aatcttctca tttggatttt
     2101 taaagtgata tattcttgaa ttgtcaatat atttttcctc gataatcgtc aacttactga
     2161 aatctaaagc cttcagacaa attcttccat cgtgacgtct ataggttgtg taagggaata
     2221 aatgacttgc attcctaaga tgctcaggaa gaccggagcg aagcggaatt gcaatcagtt
     2281 gattattgat atcaagaacc ataacaccat gtccacgcgc attatcttct tgaaactcat
     2341 ccaaatattg gtaagtatcg aaatagtctt gagttattag atgaaaatac agactattct
     2401 tattgatttt tgacataaac taaacctcta tcatacgaaa aaagggtctt tctttttaga
     2461 gtcgcgaccc ttacgactac atcaacttta gagtattttc tttttagagt cggtattact
     2521 ctccgactac ttctacttaa attataccaa aaacatcgct agtgtcaaat ataaacacta
     2581 tttcggattg aatttcttca ataaagccgc aaccaaagca cgagcctttg gcaagcgata
     2641 gaaacctgta gaacgtttaa ccccaatcct agcaaataca tcttcaatac tctcatcaaa
     2701 ctctttagcg agtaagccca aagtgatatc atacaaatcc ttgtctgctt gccttacttt
     2761 ctcaagtaaa tcttgcagca tttctgcaaa cataaattct tccaattctt cagtagaact
     2821 gtaaagagta gattcatcca tatcaatcca ggcttcatat gagataatct cttcaatatt
     2881 ctttgactta cgtgtacgga actcattcaa aaagttttca acagcatctt tatagatacg
     2941 ttccgtttta gcatattctt caggaaagac tgggataaaa gcaaccagta cataaacatt
     3001 cagctgttta gctggcctcc aagaccgaag ggtctctctt ttgagacgca tatcctcaat
     3061 aacttgttgg ttctcaacca acataggagc tagcatctgc ccctctaaaa gtccgacttc
     3121 tagggagcat tcttgttttt gacattcgtt ataaatattg tccttgtttg tcatgttttc
     3181 cactttctgt cttaagcaga gaaacgtgac aagacaaaga actattaaaa agattttctg
     3241 accacatcag caattcctct gctaattcat ggtcaactga ctttacaagt tgaactgcac
     3301 acctaatttg tacccttaaa gtcacggtaa atcagtttca ctcatttaca aagtatcatc
     3361 attaggcaac aaccatctca aattacctat tagcgctatt cgataatcga gattttttac
     3421 attcgcaaaa ctttttatgc gttcgcaaat atatttttga acatcgcaat cctgtcatga
     3481 tataataaag ttaatcatta acgattactt tgttcgactc tattgtatta aatgagattt
     3541 tgaattaagg gacagtttag tacagtacgg tacaacttgg tacaaaaatg aaaaggagaa
     3601 catcacttgg attttcccac ttattttaga attctgaaaa aatatcttgg agatggcgcg
     3661 actataccag agttttttcg agaactcatt gaaatgatta ctgaagatga cgcagaagaa
     3721 atcatcagcg cttctggaat tacatcagaa aaaactgata atacactagt ttcctatgct
     3781 aaaagaagct tctccaagaa gatggcaaat caattgctct atcgggtcaa ttcagctaat
     3841 atgacggagt ctattgaaag taggccagat gaaactattc agttactaac caatgaattc
     3901 aattcttatt atcctgatat tactgctgaa aatgcctcgc aaagaattcc agaaattttc
     3961 gttgacttca ttagagagaa agctgggatg ggaatatcaa ccacagctca aaaagctaca
     4021 tttgttaacc agtcgaatca actcaaaaaa caatatggac aattcttgtt agcagaatct
     4081 aataactgtt gtgcctttcc aggctgtgat aaatcgctca ttttaacaag aggggattta
     4141 gcatcggaaa actatgaggt ttcagccatt gaaaaagata aagacgctga accactgaat
     4201 ctgatagccc tctgcccaga ttgtttttta acctatcaag cagaaagtcg caaaaaaatt
     4261 gtaacagctc taaaaaatgt taaaaagatt ctagtctctg cacataacag ccatcgacca
     4321 atttctgaat tgaagttgga caatggaatt gttgcagttt tgactagtct caataaactt
     4381 aagtatgatg aatatgatat ctcctatgac ccaaagaaat tgactgataa gatatcgcct
     4441 gagaataatc gcacgctcta tcaaatggtt aagaaccaag ttattgataa ctacttaacc
     4501 attcaaaaaa tcatcgtaaa tttggacaaa caaggaaaaa ttgattacga ggaaatccaa
     4561 tatcaaatgc gatcaatgta taaaaagtta aaggctagca agcatgataa tctagcgatt
     4621 ttcaatacta tttcggaaaa aattcataaa gctacattac aagataccta cttctgccag
     4681 gcgatcgtct cttactttat ccaaaaatgc gaggtacttg aataatgcaa ttaccaaata
     4741 aactttattc ctaccaaaaa agcacccttg cttatttgcc tagggtgcta aatgaaatta
     4801 aaggtggaaa ctcaaacgtg aaagatatct ttcacgctat ctcagaagag ttggatgatc
     4861 ctacagattt tctatccata atggattgct tatatgcatt aaacgccatt gaaatgtcta
     4921 atgaaggaga ggtaaaatta tgcttataga aatgtggtct ccagtattta agaaacacgg
     4981 agaaattcgg gaaccaatcc gctttcatca tgggttaaac gtgattatgg ggatggattt
     5041 agctgataac tctatcggaa aatcctcctc cctattagcc attgacttca tctttggagg
     5101 caatagctat ctaaaatcta tcgctgttaa gaaattaggc gaccacccta tctacttctg
     5161 ctttcaattt gagaaaaagt tttatttcgc acgagacaca gcaaagccag atatcatcac
     5221 atattgtaac gatgattatt ctccaactgg tgaaacaatg cccctggaaa tctttctgga
     5281 caaacttaag aaaaggtatc atttagattc tccagatctg tcattccgac tagctatgag
     5341 tggattcttt agaattgcag ggaaaaacaa tcaaaatacc gacttccctc tacaagttta
     5401 ttcgagccaa aagtcttctg aatctattac cactcttatc cagcttttta atctgtatga
     5461 taacattgca cgatacaaag aacggttaaa ggataagagc gaccagctca caacattccg
     5521 taatgctcga aagtatgcct tcatctccaa cctggttggc ggtaaaaagc aatttgaagc
     5581 gaatgtctca gaaataaaaa gattggaata tgatttatca catctccaag atactcagca
     5641 agataaaatt gactctggtg atattgagaa aaatcaacaa aaaatccaac ttagaaatac
     5701 taagctggag ctagagaaca gtcttagaga taagcaaaga cgccttaagc tattggacat
     5761 cagtatcgaa tttggcttat atccaactga atctgactta acagagcttc aacaatactt
     5821 cccagatact aatctcaaaa aattatatga agttgaagcc tatcataaaa aattggccaa
     5881 tattttagat tccgaattct caatcgaacg tgaatcccta atagctgaaa tcgacgaatt
     5941 agagagtcaa ttaacaattc taaaccaaga acttcaagaa ctaggaaaca tcccaaatct
     6001 ttcaagtgag tacttagaaa actactctaa actaacagct acaatcaatg cactgaaaga
     6061 acaaaatgag gcctacttaa aggaatctag tctatccaaa gaaaaatctg aagccgacgc
     6121 tgacttgaaa cgcagtacag aagatatcct tctggattta gaagtaaaaa tcaatagcaa
     6181 gatgcgtgaa ttcaataaca ttctgtatcc agatattcgc aaagctccgc aaattaacct
     6241 caaagctcac aatagctact ccttctatac accagatgat gatggtacag gaactaagtt
     6301 caaagggatg attttatttg acctaaccat gctctatctc accaacctgc cagcacttgc
     6361 acacgactca ttactcttga gtaatattag ctaccaggcg actgaggcac ttttgaagct
     6421 gtatgatcaa tcaaagtcat tgaacaaaca agtcttttta gcctttgata aagctagctc
     6481 ttattctcca gaagctaatc aactcttgtc agaaaatact gtgttgagac tctctagcaa
     6541 cggaaatgaa ctctacggta tttcatggaa taaaggagaa aactcagatg aagtttagtt
     6601 acaataaaat atggaagttg ttaattgata aaggatggac taaatcagaa cttcgccaaa
     6661 aagcaggaat cagttcttcc accatcgcaa agctaggaaa aggagagaat gtcacgaccg
     6721 atattttatt gaaaatttgc attgcacttg attgcaagat tgaggacatt atagaaattg
     6781 taaatagtaa atagttagct atcaaacagc acagaatcaa taatctgttt tagataaatt
     6841 attgattctg tgctgtttat cctcttttaa ggtcgaatat ttacttaata ttatcaagta
     6901 atatctatta acctatatta taccttttaa atagtgttct aaatactaac gataatacag
     6961 taatagacgc accaataata aaaagattaa gtgtattgtt aggatttaat atcaccgaga
     7021 aaaagttcga ataattacat tgtggaacat aaaataaagt ggtgtagcta gcattaacat
     7081 caagctatat aatgctaaaa agatcattaa acgtttactt gataaatgtt tgttgacaaa
     7141 ttcacttaag caccacgggt ataaattaaa atctaagatt taaagttttc ttcatcgata
     7201 gtgtatataa aatacaaata ctcaaaatag aaattatata ttgactaacc tccatgatat
     7261 ttgaacccgc ataaattggc aaaaaataca ttggaatttt ttcaaataaa ttatttaaca
     7321 attcgttttg cgtagagtat aaaatattcg aaattatatt cggaataaac aatagtaata
     7381 aagttagaaa tgaaaaaaca acattagatt ttataaaaaa agaaaataat aggtagctaa
     7441 ataaataata gaaaactatc gtaatagtta aattacaaaa gaatccaatt atgaaattaa
     7501 cggtcaaatc acccgtaaca ccgagataat ttgctatcag tactgtagct accccaattg
     7561 atgagtaaaa taaagagaga aagaaagcaa gtaatacatt ggcatttaaa taagcgattc
     7621 tattttcttt agtattacaa actaatgtaa tagtatccat tgaaaaatct ctatttataa
     7681 aataaagtgg gcttaaaaca ccaatatata gtccaaaaat gcagaaaaaa tttgaaatat
     7741 gtttgatgta gaaggaatta cttccataat ttataatata atacattaaa attacaggtg
     7801 gaattacggc aacaattact ccaattatta taataccaga ggttattaat tctttaagac
     7861 aattcttaat atataatcgt ttgttgaatt tcataatatc aatccccctt gataattttg
     7921 tctatgtaga tatctcgtaa agttttttgt tcataggagt aatctaacaa actaatattc
     7981 aatttattaa ttaagtccat taattcacta tatgagcagc ttgtttcaat tttaataaaa
     8041 tcatcttgac tttcagttat tatccctatg ttttgatttt ttagaaataa atcaacatca
     8101 tttttatctc taaatatcaa tttatgtata atcctatttt tatactccct actatttaat
     8161 ttttctaatt tcccattatt caagaatata attctatcac atatcagttc tatatcttct
     8221 aatttgtgac tagaaataaa aacccctata ttcttctcct ttacaatttt ttttaattct
     8281 tgtaaaaaga caatactaga atcaatatcc ataccatttg taggttcatc taatataaca
     8341 taatctggat tgtttaataa tgctattaga actcctaact tctgtttcat tcccaaagaa
     8401 tattttttta ctttctgttt aaggaaatct attatttcta tagattgata aaaatcaaaa
     8461 taatcttcaa ttaagaattt attcccaaaa atatacgaaa aatattttaa attccacaat
     8521 ccagtcctat tggtgactaa tttgggcgat tcaatgaagt accccaagcg acctacttca
     8581 tctatttttc cttcgaaatt agtatctaac tttgaaataa tcttcatcag cgtactcttt
     8641 ccggcaccgt tctttccaac taaaccaaca atctctcctt tatttatctc aaaagaaata
     8701 tcattcaata cgacatgatt cttaaatttt ttaacaacat tatataattc catagaatct
     8761 tccctttact ttttttcaaa acggtaaatt agaacaccgc atattccgac aactatacaa
     8821 gcaattagtc ttgcaatcca aacattcata cccaaacttt ccaatattgt caatacgata
     8881 ttcccaacaa tgatacaaat tattataccc aaaaatctat taaacatatg taacaccttc
     8941 cctactataa tcgattacac atttccctaa tttattttta tcaaaaaaac ttcttgtcaa
     9001 gaactcttcc aattgaccta aattatattc tgaatcaata gtcggcgaaa tttcagaacc
     9061 atagatttca attactttat ttaagtcttc ttggcttcct aaacaatttc caattagaga
     9121 aatatttttt acaataacta attttaacga attgaatatt tcttctgtat tcaatgtttt
     9181 atcatcttct tttgataaaa caggatgttg attcagaaag ccacaaaaaa cgtacttccc
     9241 tccattacct aaaaggctta cagctctact gaaatttaaa tcaaaatacg gatcaaatac
     9301 atgcgagaat gaatcgagat attcttcaat tccatcaaca cttactactt tttttatccc
     9361 aatactatct aactcttctt tactccattc actactagaa caacatacta aatctattcc
     9421 aaaataattt aaaagttgaa ttataaatag agaagtaact gatcttgaac taaatactac
     9481 tgctttttta ttctgttttt ccaatattcc agacttccta atcatactgt aggcagtctg
     9541 tgcacctaaa ctaaagcaag ctgcttctaa atcggacaac tcatgaggct gtttaataag
     9601 cttctccctc ctaattctca accagcctaa tgatgcaaaa ttagttgtca cacctggaac
     9661 aacattatca ttagtaaccc cttcataagt acagttagga attactttat caccaatgcc
     9721 aaactcatct acatttttcc cttttaatac aatagtagcg ctaaactcag atccgaaagg
     9781 aaggaatggc tttcctaaac gaagcaattg ttcaaagtta tttaccaata tagctttgtc
     9841 tcgataatta cacgaaaatg agttaacttt tatcaataaa taatcgtcat ttttgggatt
     9901 atttaaatca aatactggct gttcaaactc tattaagcca aatggaattt ggatattccc
     9961 gaaattaatg tatacgacat taatagcctt gttaattata tcatgctttg gatttaacgc
    10021 tacaaccgat aacattgaat gtctcctttt tcaattgttc ctgatagtca atagtactta
    10081 gatttaaagg aatccaatgc tgtcttccat cttttactaa gtttagtaat aatatcgtgt
    10141 caatcacacc actccacccc atcatataac ctaataggta ctctctgtta ctttctccaa
    10201 tataaaaacc gtcactctgc gcttttttat aaactagatt ccaataacta tcagctagtt
    10261 caatatatct tttatccttt gttacaatat aacaaaacaa taaactttgt atgactccgc
    10321 ttgttccatg gcaaactgat aaatcaattg acgcattttc aggtaagtca acacatttta
    10381 atgcaagttc gaaataatca atttttatat ttagtacttt tgacatttct accaaaacca
    10441 ttaagagacc tgaataacca ttacaccaac ctggtaatat ttttccgttc ttataacatt
    10501 taagagtttc gctatatatc ctcatacact ctttgttaag atctaacttt gcataaattc
    10561 taaattttgt ccataactca cctaatttac catgggccaa accgaatttc gagtagtcgc
    10621 tagatgaatt tgctaattca atctctcctt gtaccattgt atccaagcat gttcttgaat
    10681 aactcgctaa aactaaatat attcctaatt taccattgaa tacatctccg attggaatct
    10741 cactattttt tacttttaat tccaaattcc ttacttgctt atcactttta gaaagtataa
    10801 aatctacgga ttcttctcca gcaataattg aatggtaatc accactatca ccagcatata
    10861 cctcatctct taactttatt aaaccgtttc gagcctcttc aaaaataact ctactattcg
    10921 aggtgccttt agctaacaac aggctttcta acataatttc aacaccacct atatcatgga
    10981 aagatatcaa agtgggagta ctatataggg caggtaattc accataagaa ccgttgtgcc
    11041 acgctcgata ttttgtgtta ttcatttcat agagaacgga ttgagctttc caccagtcta
    11101 atattttttc aaagtttcca ttttttaaat ccctaagtaa atctatatac attttagaat
    11161 tgtcacgatt tacattcccc ttcttagaat ttctaatttt aatttctgaa aaaccttctg
    11221 aaattagacg ataatcaaat aaaagctgtg agtcactgag gtactttaga ttttccagag
    11281 cattggtaat tgctgaaact gagtagactc ttttgtaagt attactatta ataactaaat
    11341 ttaagctatc agattcaact ttaaaatatg gtatatctcc ttgaagtaaa gatttacatt
    11401 cttcatcata aatcattttc gctattgtct tgtctttaat aaaagaaatt ggctttagat
    11461 aatgcaatat ctttttcgca gaagaataat caatcaagtt ttccggatat aaacatgcat
    11521 ccataattaa aaagtattga gcagtaggtc ttaacactac tcttatatcc cctttaaatg
    11581 attcgacctt cttagaaatc atagttttat tgttcattat gtctataaaa ccactcttat
    11641 atcctgaaag gaaatcatca taataattta caggatctat aatttttcca tcagtacaac
    11701 ttaaaggcgt tgctaaacga tctaatacta ccttctcttt tgcaatatca attgcatctg
    11761 tgcccaaatt tttaaatgaa aataccattt tttcggtttc ttggggatat ggagtgttta
    11821 tagctccaat caagtaatta tatgaattat tcaataattt cgaaggtata attgttgtgt
    11881 gcgcaattga ttttgtaata ctgttttgta attctccaat taaactttgc tctgtactat
    11941 ttaatcgtgg gtgaagtgca gtttctaaat caataaagta tggaacttct cctctaaaaa
    12001 ttaaattttc atcatgcaag tcactggcac ccaaaaccga aaataataca ctatagtagc
    12061 ccagattata aaatgataca cctacatttg cacgtatgac tggtacttgt tctacaaatt
    12121 tctgccaccc atacccatct cttattatat tttgaggaat cggagactcc atgttttttt
    12181 gggcgtttaa aaacagtgtt ttaaaaatat catttataag attatcaatt ttaaaatctc
    12241 tatttttaaa aataaacttt cgacaatccg tatcctcaaa aaggagaaca attttgccat
    12301 tattgtgtgg atctgaatct aataaagtta tcttgtttat ctgagcttcc ctgcccaaaa
    12361 accctctatc tattaaaaga gatttatctt cagcataata ataaaatact tctgtaataa
    12421 atttacaaga atttagaatt gagtcttgca agattccatg aagaacagta tattttttta
    12481 accattttcc aattacatct ttattcattt ctgataaaaa catctcatat gccaatgatg
    12541 acgttttaga aattggtaaa cctttttgtt ttctaaattc atgaaactca taaacaaacg
    12601 ttttatttat tattctccaa gcttgtttag cgattaaatc atataaaaca tcaataaagt
    12661 tttcaataat tttatcacca ccatttgatt gattaatttt tgatattaat aattcctttg
    12721 ccttattaat atcactctca aaataattta tcactgattc gataactttt gaactttctg
    12781 atatcatttt ttattctcca aattctctgc tgtaaataat tttgaataca atcctccggc
    12841 ctcagtaatt aattgatcat gagtaccaac ttgagatatt tttccagact ctaatacaat
    12901 aattttatct gcatttaaaa tggtttctaa tctatgagct ataattattt ttgtacagtt
    12961 cattacattt aactcatcgt aaacatactt ttgtgaaaca ttgtctagcg aggatgttgc
    13021 ttcatccatt attaataatt ctggctgctt tattaaaatt ttcgcaatct gtatacgttg
    13081 tctttgcccg ccggacaaat tcccccccat ctcagaaatt tgagtattat atcccattgg
    13141 taaattattt atgaaatcta aaaaaggaat atttttacat tttttaatta tttcatcgcg
    13201 ctcagtttca caacctaagg caatattatc tattatactt ctgttatgaa gatatgattc
    13261 ttggggaata tatcctatcc tatttctaaa actatctaat tcataatcct tatatgaaat
    13321 accgtcaaga taaattgttc ctatggtagg cataaataga ctactgatta ttttgcctaa
    13381 agtagatttc ccggaaccgg attctccaac taaggcgata gtttctcctt tttttatttt
    13441 caagttaata ctccttaaag catatatatt attcccgcta taactaaagc ttacattatc
    13501 taaaacaagc tcgtctttaa aaatttgata ttttatatct ccagaatttt caataggata
    13561 ttcatatatg tcttctgcta aatctacata acgatttaat acagaaaaat ttgagaaagt
    13621 agtaaaaatt gaattggcgt aattataaag tagtgatgta accgtctgtg tcgcaatgga
    13681 ctcgcctaaa ctcagtcgcc ccaaagaaaa ttgaaacaaa gccatcgaca atataacaag
    13741 tgggacaaag gcactcacca tccctaaaat ggtgcctatc caagattgtt gaatattcat
    13801 tctttcggct gtgtagtcca aagatttttt atacttgctt gcccaatctt ccttataagc
    13861 ttccttatat cctcctagct tgatattatt aatggacaca attgcatcta gttgtatact
    13921 ttgggctaat gaagcctggt gaagttcatt atcacttgtt gattgaattt taggctgtaa
    13981 gttaattaat aatgtaaaaa gcaacaatat aaaaagcaac tcaactccag ttaaaataat
    14041 tgacacgcca gataaataaa ttaaaattgc aaacaagcta atgatgtcca aaaataattg
    14101 gatcaatgat gttccaaata aatcttgaat tctagttaat gaatttaatc tatagacaat
    14161 ttctcctgga cttcttacag taaaatattt tgaaggcaaa gataaaattc tattgaaagc
    14221 tgtacttaat aaatgccaac tgaaattctt catcaaagta attgacaaaa cagatttaaa
    14281 gtaaaataca gtacccgata caatacctag aaatacaata cttaaaatta tatatcgaaa
    14341 atcgtaatta tttgtttgga ctgaatcaat gagtaattga gtcaaaactg gtatagaaat
    14401 attaatagct attactagaa cggaagtaat tattaatccc aaataattat ttaaaatatc
    14461 agaaggaatt aattttctgt aattatatct tttagcaaaa cttttttttc tttttctaaa
    14521 agtttcattt ggataagatg caataataat ttccgaaaag ttttcaaaaa aatcttttaa
    14581 atcaattttt acacgcccaa ttgagggatc catgataaat gcatgattat tctctatttt
    14641 ctctatacat acaaaatgat atcctttcca aaaggcaatc acagggaagt ctattacttt
    14701 gaaggcgttt ggattattaa ttttatatgt atttgatgtt aaattaaatt tttgcaacaa
    14761 tttctttaat tgcttagtac ttagtccatc tcttccaggt tcttcaattt gtcttaattc
    14821 cgtaattgat atatcaaaac cataatactc aagtatagtc ctaacacaac acagaccgca
    14881 ctcagtttgt gcaatttgca gtgttggaat tagttttttt ctcatcctca tagtgtttct
    14941 ccaaagtgat aggtgaaatt ttaaaatcaa tatttaactt acacaaataa taaacagctc
    15001 cagaaattcc ggacatgaaa cccggactca atgtatacct acctttctcg cttttaaaat
    15061 aatgatatat tacattacta aaatctcctt taaagtctgc cataaataaa attgaactaa
    15121 catcttctaa aaagtctgat ttcatataat ttagaacttc taaaattcct agtattccat
    15181 ggcaatacac aggtaaagtt gttattcgta atctttttaa ttgttgtaaa agcaaactaa
    15241 catctttttt atctactata ccagctttaa atccttcata atatgctagt aagacccctg
    15301 aaacaccatt acaccatgaa tctgattgat aatccgtccg ttcataaata tttatctctt
    15361 ccttttcaga ataatagttc tcttttaata tttttaaaca atcattaata agctcacgca
    15421 cagctgctgt tgggtaggtt tgataaataa tactaaaaaa ccaaataaga tgagaaatac
    15481 catggactaa tcctgaagtg gtcctctcgt ttctattttc taaaactttt aaagcttctg
    15541 aaataaaaag ttcaatctga taattattta attgaaactc tttatccatc tttagccgca
    15601 taataattgt tgcactattt cccgacatca tatcaaagaa acctgatttt acagaacaaa
    15661 tttcttcatc tattattttc caagaatcta ttgctatttt cttccatttc tcttctttaa
    15721 aaatatgact tgcttcataa agcccccaaa ttacacttgg aaaaccagaa tataaaccaa
    15781 ttcctgaaga aagtatactt cttgtttcat atacgttaga ttctaatatt tttgcatatg
    15841 cttcgaagat ttgaaatgct aaatcagaat atcttgtttc accaagtttt gtaccagcca
    15901 acgctaaaac gagagcaata cctgttcgac caccatacat atcatatcct aaaacacctg
    15961 gagtccaacc attcgttgta tgggtggata caggaccaat ccaagttttt ggcaaatgtt
    16021 catatttatc atcgtagact gaattcatta atttatccga taataattta ataatttcat
    16081 tacttgtttt caaggaattt ttcagtttaa atgcttcggc attttcacca tgaggatcct
    16141 gtactttggc aacaaaagct agttttatta tcttaagctg ttcatttaaa tccttaattg
    16201 acaatgattt tatcttatct tcaaaattac tctttggact agaatttgtg cgtgctataa
    16261 ttttttcatc ataatcataa atataatttt cagaataatt agcagtaaaa taggggacat
    16321 ctccattcca aatttgttga cactccgaaa tgataattgg tttctcacat gttaaactta
    16381 acactcctag tctagagagt attgattttg aaagtgattc agacttggaa gctttagtag
    16441 atgttaatgt tcttaaaatt tgttcataac gataagtcat attatgaata tatctcacct
    16501 tagaattact gaaaatttta gataccgtat ttaaaaacca ttccttatta ttaaaaacca
    16561 attcatacat ctcactaaag cccttagaaa cttcatcgca attctgaaaa atctgtagat
    16621 tctctgaaat attatttttc atgtttgtag tagatggata ttttccccaa ataaatcgaa
    16681 tattggacgt aaacccgtct agtagttcaa tcgatttaat tgggccaatt gagttactgt
    16741 tcctaacacc agtaaaacca acatctaccg ttccattttt actgactaag ttaattggta
    16801 gtactcctgt actataaaca gattgttcaa tatatttata agcacttttt tgtgactctt
    16861 cgagaccttt ctttaatctt ggaacatgaa ataaagtttc tagatctata ggaatcggtc
    16921 cttcttttgt ccaataaata ttcgaatagt gcatatctgt agcatttaat aaatacaaaa
    16981 gacatgctaa ctttccagct tttaccatgt caatactaga atcatcaatt tcaacgaatg
    17041 aacaaaaacc atatttaccg actttcaagg tatctacggc taaaaaatta gttttaaaag
    17101 ccatatttaa ttcattaact aatttagcat atccatactc tccatcaaca gttcttggtt
    17161 taaaaattaa tttttctcca ttttcaaata tgattgtcga aactgtctta ccacaattat
    17221 gactatcacc atccataaga atatttttta ctctcaattg ctttgaaatt ttaaatttat
    17281 tttgaatttt atctcttgat tttgtgagag tatttaatac aataatgata taattaactt
    17341 tgttaataac taatttatta catctatacc agataactgg atattctgat gaaaaatttt
    17401 taaaacagtt atcaataaga aaccgactat actccttata attctttttt atatctgtat
    17461 tagttgaata ttcttttatt tgattagcaa aacatctaat aaaatatgta aaagctacct
    17521 gtgccaatga ttcacagata gcttccttga agtcttcaga atcaaataag agattattta
    17581 atttatcatt ccaaagtttc ttccaaatat tatcaacaaa gaataaacaa gaattatgat
    17641 atggataagt ctcttcaata tttataaaat catttttact ctgacttact atttcacctg
    17701 ttattgtaag atgtttaatc ccttcaataa taggtaaaat atactcatta aattcagatt
    17761 cagattttag ttctggataa atatccttgt catatcctac cataattttc tcctaattat
    17821 cagcaggctc ttgtacaagc tgaagtcgga caagtgtttg ctgaaacaaa cgcagttact
    17881 gcaatgacac ccttaccaat cgctggagta tatggagtcg ctggagttgt accgccatca
    17941 acattttcgt cagttagaga caataaatct gattctaaat atttaccaag ttctaaatta
    18001 ttttgttcca ttatattctc cttctttatt tacaccaatt catacattca tgtgtcaaag
    18061 tacaccaatt tcctttattt ccccaataat cactcaagga aaaagtatta gtcgtacaag
    18121 caccgaaaac atcttcatca aactcttgaa aaagaatttc attttcaaga gtaacctcgc
    18181 tatgtttatc catgacaaac tcctttcaat ttttttatat tttttaatag agaaatatat
    18241 aaaactcaga tttaaaaaga tcctccttct caatatttgt ttagagaaaa taactacact
    18301 aaaaatgaac tttttatgga aaagtttgaa caaatagtgg tactgagtct ttagatactc
    18361 taaagactta ggtgtacacc taagcgattt acccaccaac gatgataatg atgtccatta
    18421 ccaataccaa aattgggaca agttttgaaa ttttcttcat actcagactt cctttcagtt
    18481 tttatttatt gtacaataaa taaaaactga gttaattttt gttgggaaaa tgagaaaaat
    18541 tatgaaatca aaacttggca tcacacttag aaaagttcgt aaaggaaaac aaattagtct
    18601 atgctctgta gcagatgaac atctttcaaa atcacaaata tctcgttttg aacgtggaga
    18661 gtcagagata tcttgtattc gactaatcaa tattttggac aaattacatg ttactttgga
    18721 tgagttcctt attttacata atgaagacta taccaatggc gaatcatttg ctaacctggt
    18781 acagtacatt cgtaagcaat attcatcaca aagtatcaat aatatagcat gtctacttta
    18841 cgacacttct aattacactt taaattcttt ggagaaaacg atggtaaaat ccattttaca
    18901 cacaatggat tcgaacgtca ttccatcaga tgaagagtta cttcaactga ccgactatct
    18961 tttcaaagtc gaaaaatggg gctactatga aatcatttta ttaggtaact gtgtacgcac
    19021 aattaactac aactcctact tcttattaac caaagaaatg ttaaacaatt acatttactc
    19081 atctctgaat aaaaccaata agcgtattgt cactcagctc gctatcaatt gcttaattct
    19141 tagcatcgat aaggaaaaat tttctaattg ctcctattta attgatgaga taaaggcgtt
    19201 gttagataat gaagtaaact tttatgaaca gacagttttt ctctatgcaa ctggttactt
    19261 tgaatttaag cgccaatcag gcactggaat tgaaaagatg aaacaagcca tacaagtact
    19321 tgatatttta ggagaggata aattaaaatt acactacact agccattttg ataaactgat
    19381 aaagaataaa taaaatgatt atctactatt taattttcct cctttttcgt cctgatcact
    19441 taggctataa atggaagctc agaaccttct tagaaattag cttgaagcca tagtaaaaag
    19501 ccttggtagt caaggctttt tactatttat cttgtttcaa agtctctcaa tctttcaagc
    19561 agaacaacac actttatgtg aactaaataa tttcttccag acgaaatatt gattaaatga
    19621 tgattaaatc tatactacca tactaagcaa attttaaatt agtagtcatt ttttctagtt
    19681 tgctattgta catttccctt aactgtgcta aatcagtatc tctattttca gataaaaata
    19741 ccctatattg catattttca ttgggtattt tttccgttaa aatagaatcg taaattgaaa
    19801 atttgtctcc aatttcaatt ttcactgtat ttactaaaga aaattctaca tctttgtttt
    19861 ctagtgcttc taaaactaca ataattgatt ttaatagcaa gtagctgcat acacctcttt
    19921 ctctatactt aggtagcaca ctaatacttc tatacctgaa attaaaatct gcagttttgg
    19981 taacactata gtttatacca atattacgaa aactaaaact ctcagaaatt gcattatcat
    20041 taatcagcaa ttctaattct acacagccat cctcttctaa tagagagtca aatgtctgat
    20101 tctcccaatt ttcataatac gtcttaatct tgatccctcg ttcttctaaa gtagtatcat
    20161 taaatctagg atcatagcct tcctcttcat tctctgtttc gttttcaaaa tcagatatgg
    20221 acttttttaa gaaaaatttc ttcaaactat cagttaaata ttcaaaccaa gccattttac
    20281 acctctgctt atcatacaac tttctcaata gatagagctt gtctactagc caacttcagt
    20341 tttggaggga atccttttga aaaatctaaa tggccaattg caactaaata ataatctgca
    20401 tcttcttcaa ctttaagcaa gactttatta ccgaggtata tgcttgcttt ctttttccat
    20461 tccctattcg aggccttaca aaaaatattc aaaaaataaa gagtatatcc ttgttcatta
    20521 tgccattctg aaatgcttaa acgtacttta ccatagaaaa gatgaagttc atcttcaagt
    20581 tctttatcta gccatttttc aatacttttt cttcttaaag ttttatgatg tacttgtctt
    20641 tcaacctttc ttgtcagaac taaaggattt tcatcactag aatctcctag atttactggt
    20701 gtttgaggca aatattcttt tttgaaaaaa agacttctca tcatggcatc aagcttatct
    20761 ttaatttggt catcacgaag atttttaaaa tattcttcaa tatacttttt gctagcataa
    20821 tcaaattgat aagagcacca attggtgtgt ttagaactag tctttctttt taaatgtgct
    20881 ctcctttgtg aagtcttagg gacgtaagat aactctgctt gtctgcactc tgggcagaac
    20941 atattatcat gatagattcc taaattttta tgttttataa aataatcatt taaagtctca
    21001 atatcttcta tctcatccgc agtgcaaaag taaaattcat caaatgattt tggcatattc
    21061 cattcctcac atacagtatt ttaaaattaa atattatgaa tgattatagc attttataac
    21121 atacatttct actgataata ttatgcagtt gtactgcctc aagatgatag gctttgggaa
    21181 catacaattt aacgtttaac aaatcaaggg tgtcttcata gaatcaaagt atttcttata
    21241 cccatttcct tctatctata gacagtaaaa agccttggaa actgctattt ccaaagcttt
    21301 ctttgtgttc tattgtatca atttccttat tccgatatct gttgcaacta attttatatt
    21361 cattttacat actttctaaa tcttttaatt ttacggagac aatctttgat acaccggact
    21421 cttgcatggt taccccatag atagagtctg ctgcggacat cgttccttta cggtgtgtta
    21481 ccacaataaa ctggctgtcc ttgtcaaagc gattaagata gtcgccaaaa cgtttgacat
    21541 tagcttcgtc aagtgcagct tccacctcgt ccaaaatgac aaatggtatc gtcttgacac
    21601 gaataatgga gaagagtaat gctaaggctg atagcgcctt ttctcctccg ctcatcagat
    21661 tgagtgattg gatttttttg ccgggcggtt gaaccgaaat ttctaccccc gcagtcaaca
    21721 ggtcgccttc ggtcaaaatc aagtccgctg aaccgccacc aaacatctgt ctgaaagtca
    21781 ctttgaagct ctcacgaatc gcttcaaagg ttgatttgaa gcgttctttt acttcgtcat
    21841 tcatttcttc aatggtttcc aaaagcaaat ttttcgcaga gagtacgtca tctctttgag
    21901 tattgaggaa atgcagtcgt tgactgactt cttcaaattg ctctaccgca tcaagattga
    21961 ctggtcctaa agcccgaata accttttcta agtccttaac cttagtttca gaaaccgtaa
    22021 gattttctag tggacgagcc tgtttactag cttcatcaaa agatatttga tagtcatctg
    22081 tcaaattcgt caaaaggcga cgcaagacat ctgcaatctt atctttttca gcttctgctt
    22141 ttgcctgttt gcgaatcaga tcctcatttt gctggcgggc ttgttccaga tgactagtaa
    22201 gatcctctgc ttgcccttcc aaatcgtcca gttcaaactg acgacgaatg gtagcttggt
    22261 tcaaagttgt cttttcctgt atagcctgtg ttaattgctc ttctaaaaca gcaatatcca
    22321 cttttgaagc gttttcttcc ttttgctcca ttagaaattg taaagttgaa atccctttgt
    22381 ccaattcaga tttttcattg gacaaacgcg tgagatccgt ctgaacgtaa cgctgatgcc
    22441 ccgtcagctc ggtacgagcc aaacgaagct cagataagcg ggctgttagc ttgtctaaac
    22501 gtgcttgaac agcatcttta tccgacttaa tctgctcaat ctcggcttct gtttcggatt
    22561 tatcttgctc aatttctgca aggcgattga ctaacttttc tttttgctcc gccatatcag
    22621 gaagaacttc acgagataac tctctttctt gcagcactaa gagctcagat aagtcttcaa
    22681 cctgtttgtg cgtttgctca taagccattt gagccttttg ctctgctaat cgtgcttcct
    22741 caccacttac ttttatttct tctaacagac tgttggcttg gcttagctgc gtgtgcaaat
    22801 cttccacttg tttttcttgc tctgctaaag tcgcattctt ctcagaaagt tccatttgta
    22861 aagcgtctag ctccggcttg atgaaaatcg tattgttatt tcgattagcg ccacctgcat
    22921 aagaaccgcc tgtccgcagt tctgttccat ccagcgtgac aattcgtact tgataccgaa
    22981 ctttgcgagc ggctgctcgc gcattttcta ccgtatcaaa aatggctgtt gtacctagca
    23041 aattttggaa aatatgctcc aaactcttat catagcgcac caaagacgaa gccaaaccaa
    23101 gaaaaccagt gcttttttca atgcttcctt gatgatgatc tggtaaatgc cgcgctttaa
    23161 tcgttgtcag tggcagaaaa gttgcccgtc ctgttcgatt gcgtttcaga aattcaattg
    23221 ctcgtgtcgc agcttgttcg tcctctacga taatatgctg gctacttgct ccaagtgcaa
    23281 tttcaagtgc tgtctggtaa tgcgaatcaa agctcaattt ttcactaaca gcaccgataa
    23341 taccgcccag acactctgct tcttgaagaa cgcttttaac cccagcatag aaatgactgt
    23401 gatttttcag aatagcttct aaactaccaa cacgcgcctt tttatttttt acatcatcca
    23461 ttaaatcaaa cattgccgtt tggttttgct gataattcgt ttttacagtt tgcacttgct
    23521 ttagctgtgc ctgataatct gtcagtaact gctgaaccga ctgccgagct gttgctaaat
    23581 cttccagttg actttgctcg ttgatttgaa gattctttaa attttctttt aacttagcaa
    23641 attctacttg tttgctttca gataattgta attcgttggc taagcgactt tctaaagcag
    23701 ttaagtcatt ggataagtcc gcttcttcct gcatcaattg gacaaattca gcacgtaatt
    23761 tttcaatcat ctggtcagga tcatccgaaa atgcctcaat ttcagcttct aatttatgaa
    23821 tcgcttgttg atttcgttcc aattttacat caaaatcaat caactgctcg tctttcccct
    23881 gccattctgt ttgaaccgcc tctaattttt ctgtcaatcc tttcaggcgt tcctcatttt
    23941 ccttccgact gttggcagct tgactagatt ctaatttgga aacttcgatt tggcgttcta
    24001 agtcactgat gaggcgggtt agttcaagca aactcacttg gtcatctgcc atttgttttt
    24061 gcaaatcatg gcgtttttct ttcagaagag cattttcttg ctctagctgg tcacgtttgc
    24121 tgtaataagc agacaaagat tgctgaatcc ccacaagccg ttcttcagta tcattcagct
    24181 gtgttttatt tccctttatt tgagcaatca atacacccaa ataaagagca cggcgttcct
    24241 catccaattt caaaaactgc ttagctgtcg tagcttgctt ttcaagaggc ttcacttgac
    24301 tatcgagctc ataaataatg tcttccagcc gatctagatt atcttgtgtt tggctgagct
    24361 tactttcagt ctccttgcgc cgcgtcttgt atttcagtac gccagccgct tcttcaaaaa
    24421 tggcacggcg ctcctctggc ttgctattga aaatttcttc cacctttcct tgagaaataa
    24481 tggaaaaact atctcgccca agccctgtat ccataaacaa atcatgaata tctcgtaaac
    24541 gtaccttctt gccgtctatt ttatactcgc tatccccact gcgataaata tgacgctcca
    24601 cacgaatctc atctgcagct tgctggataa aacggtcttt attgtccaaa acgacaacaa
    24661 cagaagcata attcagtggt ttgcgagttt cagtccccgc aaaaataaca tctggcattt
    24721 tcccgccacg aagactttta acactggact ctcccagtgc ccaacgcagg ctttcagtaa
    24781 tgttactctt tcctgagcca tttggtccaa cgactgctgt cactccctga tcaaatatta
    24841 ccttggtctt atctgcaaaa gatttgaaac cttgaatttc aatttctttt aaatacatga
    24901 atgactttcc ttttcaaatg catttttagc agcttcctgc tctgctaatt ttttcgagcg
    24961 tccttgacct tgtccaaccg ttctgccatc aacagatacc gctacagcaa attctttagc
    25021 atgagctgga ccggactcag agatgacttg atagacaatc tcgacatcac cattgacttg
    25081 gagcagttct tgtagcttgg tcttgtaatc aaccacctgc tcaaagtctc caacttctac
    25141 ctttggaatc atgacttgat acaggaagtt tttgaccgct tccactccct tatctagcaa
    25201 caaagctcct aaaaaggctt caaataaatc cccaagaatg gtatcccgat tacgcccacc
    25261 tgacttttct tcgccacgac ctaatttgat aaattgatca aactggcaat ctcgactaaa
    25321 accagccaaa ctctcttcac gtacaatggt tgagcgaagt tttgacaagt ccccttctgg
    25381 ttttttcgga tattttttat acagatattc tgaaatcaat aattgcagaa cagcgtctcc
    25441 taaaaattcc aagcgctcat tgtgtgaaat gtttaagagg cggtgctcat tggcatagct
    25501 agtgtgtgta aaagctgttt ccagcaactt ttcatcttgg aagacaattc caaattgctg
    25561 actcaaaact ttatgtaaat ctctcatttt ttctcctttc aagaagaact ttttctttta
    25621 atacttaatg aacatcaaaa atttgacaat cacctccagc tgtctcccag acaattggaa
    25681 ctagaaagca agctgcgggg gagcaaaagt tcaagtagag cttttgaagt tgcaggtgta
    25741 atcaacgaag tcagcaacaa agagtacagc aaggttggca aaagtttcgc tttccttctt
    25801 tgccacctct cacagtcacc cgaactgtga aatccgacga agtttaaaga gatcttcaca
    25861 gagtataaaa tgaaaacaaa ttctctatta ttatatcaaa aaatacttga tactccaacg
    25921 ataccaagaa tttgatagga aaagttcacc agagatgaaa tgaattttca ttctttatct
    25981 agaatgactt tgaataaata atacgtcata aaaagggtta aggtagctaa agcaaacttc
    26041 acccagataa gaggtgcaaa gaagatagaa attcccatta gaatataaat ggaaataaga
    26101 atttttctct tacgctcccg agcaatggca cctgtttcgt gaaagtccgc cacatagatt
    26161 tgatacaact tagtgtggta caaccattat tcaaaccgct tagaactgcg taaaaaacaa
    26221 gtaacagaca gcagtaaaag gaaagcttca acaagagcag cccccaaagc agtgaaagca
    26281 atgaaatgat taaataaaaa ttcacattga ctctcctaaa tatcagtcaa tggagttgcc
    26341 gtatctggag atgtatcaca aatatgaaaa tcatgctcaa ccgccaaatc agtctgttcc
    26401 aattgattaa ccattgtgat atgagccaat tctttggtat tattttcttt gctaagatgc
    26461 cctagataga ttttcttagt gcgataaccc aacgtacgaa tcatggtttc tgccccgtca
    26521 tcattcgaca aatgtccttg gtcagataaa atccgctgct tcaggctcca aggataagct
    26581 ccactacgaa ggatttcaat atcatggttg gactcaatca aatacccgtc cgcattttca
    26641 ataatccctg ccatacgatc gctaacatag ccagtatccg tcagtagaac aaaactttta
    26701 tcgtctttca tcagtcggta aaattgcggt gcaaccgcat catgactaac accaaaactt
    26761 tcaatgtcaa tatcgccaaa tgtcttggtt tttcccattt caaaaatgtg cttctgactg
    26821 acatcaatct tcccaagcgc tacttccata gcattccatg ttgcttgatt ggcataaatg
    26881 tctaaatgat atttccgtgc caaaatgccc acaccatgga tatgatcctt atgctcatgc
    26941 gttaccaaaa tggcatccaa ctcctctggt ttacggtcaa tttcactcaa taagctggta
    27001 attttcttcc cagataagcc cgcatcaatc aacaacttct tctttggagt ttctaaataa
    27061 aaacagttac cggtagaacc tgacgctaaa atactgtact taaatccctt ctcgttcatg
    27121 ctacccttct aattcatctt cttcccaatc atcatctttg acagcttcct tatcataagg
    27181 caggacaata gtaaaggttg aacctttgcc gtactcgctc tttgcccaga taaagccgtt
    27241 atgctgcttg ataatctctt tggcaatggc taagcccagt ccggacccac cttgtgcacg
    27301 acttctcgct ttatctacac gataaaatct atcaaaaatt ttcggtaaat cttttttagg
    27361 aattcctaag ccttcatctg aaatcgacaa aatcatttgg gtatccgtcg ttttcatact
    27421 gaccgtaatc ttgccaccgt caggagaata tttaatggca ttgttgataa tattatcaat
    27481 cacctgtgtc atcttatctg tatcaatttc gacccaaata gagttaatcg gataatctcg
    27541 tataatttca tactttttat catcattctg gcttctgatt ttatcaaaac ggttcaaaat
    27601 aaaggtgata aaagctgtaa aattcgtcaa ttcaatatcc aaatgactgg ttgcattgtc
    27661 aatacgtgac aaactcagca agtccgaaac catgcgcatc atccgattgg tctcgtctaa
    27721 tgaaaccttg atgaaatccg gtgcgactgg ttctgataag gcaccttcat ctagtgcttc
    27781 cagataagac ttgacactgg tca
//
