LOCUS       NZ_CP035434            22835 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Streptococcus pyogenes strain emm75.1 chromosome, complete genome.
ACCESSION   NZ_CP035434
VERSION     NZ_CP035434.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1887700)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Atlas of group A streptococcal vaccine candidates compiled using
            large scale comparative genomics
  JOURNAL   Nat. Genet. (2019) In press
REFERENCE   2  (bases 1 to 1887700)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2019) Department of Microbiology and Immunology,
            University of Melbourne, The Doherty Institute of Infection and
            Immunology, Melbourne, Victoria 3000, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005163865.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 01:48:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,868
            CDSs (total)                      :: 1,779
            Genes (coding)                    :: 1,714
            CDSs (with protein)               :: 1,714
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 36 of 65
            Pseudo Genes (incomplete)         :: 31 of 65
            Pseudo Genes (internal stop)      :: 25 of 65
            Pseudo Genes (multiple problems)  :: 24 of 65
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:28:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1604661
            Orig. end                         :: 1627496
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035434.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22835
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="6"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22835
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22835
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12835](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12835)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(60..73)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     misc_feature    complement(657..670)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     gene            914..2494
                     /locus_tag="ETT65_RS08200"
                     /old_locus_tag="ETT65_08190"
     CDS             914..2494
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982804.1"
                     /locus_tag="ETT65_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08190"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_136128094.1"
                     /transl_table=11
                     /translation="MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKL
                     LLAVCDNLEKHFNTFTEAQKIFEDAYQDEDLKDDLISVVTGDLGYFIEPTLTFEKLIQD
                     VYHNTFQLESLAQGFHDIEQNGEDFENLFEDIDLYSKKLGSTPQKQNQTIANVMKTLNE
                     IDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLSCEDQKGMTL
                     YDPAMGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNAD
                     TLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHG
                     FYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTII
                     ILKKNRTNKDVFFIDASKEFDKGKNQNTMTDDHIKKILDAYKSRDNSDKFSYLASFDEI
                     IENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEA
                     QDELDTFRN"
     gene            complement(2706..2906)
                     /locus_tag="ETT65_RS09855"
                     /old_locus_tag="ETT65_08195"
     CDS             complement(2706..2906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988115.1"
                     /locus_tag="ETT65_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08195"
                     /product="hypothetical protein"
                     /protein_id="WP_063812357.1"
                     /transl_table=11
                     /translation="MPDMKSFLNLVKQKLFKPGLKKLVKLHNSQNVNICLYINDWNYFM
                     VRAMVFVEGSKVVLKISLNRV"
     gene            complement(3048..3653)
                     /locus_tag="ETT65_RS08210"
                     /old_locus_tag="ETT65_08200"
     CDS             complement(3048..3653)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /locus_tag="ETT65_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08200"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002982799.1"
                     /transl_table=11
                     /translation="MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSK
                     YDIILLDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSKKGFSIKEIEETLQ
                     ISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            complement(3634..5196)
                     /locus_tag="ETT65_RS08215"
                     /old_locus_tag="ETT65_08205"
     CDS             complement(3634..5196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /locus_tag="ETT65_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08205"
                     /product="hypothetical protein"
                     /protein_id="WP_136128095.1"
                     /transl_table=11
                     /translation="MIRIKNITKSKFFGTAIILLQQLIALLILIYHRKNLSLLFSEKVA
                     LVMTLIDAAFIWLAVILRQKQDDIFKRIISIISLTIWQYLVSVLIRGTPLFLSSGLQII
                     LLYCYTVEITNLILYGHKQFKDKLDKGLLIIIFVSITSLFVNRILFNFLFLMVFTILHL
                     YPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGSELYGEMLDVNQAFNNLGWYLFP
                     LIMSVIYYFKTIHDKLSFVTQRWLGDYKARIELLFLLLILCWIVLMKVLVKDFLLFFII
                     VDASTLFCLVVISCIFYYLENSKQNFDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNI
                     IAIKNLLSLENSNITHGFIVNELNDLVSGIRDEMDTYHPIVPANQTMKENIQSLFDDIV
                     KSRKSNTLLYFNCSDNMVVPSPYGDIVYRFIKELINNAIKYGDGKDIRLSLTIQSDIII
                     IEESNQVVEKVHSINYGRGLKSFQETLAAFDGDLELQMDTKQFTIRILLPIDWKLCYED
                     FIN"
     misc_feature    complement(5162..5182)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.44"
                     /tool="antismash"
     gene            complement(5236..7143)
                     /locus_tag="ETT65_RS08220"
                     /old_locus_tag="ETT65_08210"
     CDS             complement(5236..7143)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561001.1"
                     /locus_tag="ETT65_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08210"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_032459919.1"
                     /transl_table=11
                     /translation="MIWSITKSNIKKNFSLYRIYFLATIGLLSIFIAFLNFISDKIITE
                     KIGDSGQALVIANGSLIFLIVFLVVFLIYFNNFFVKKRSQELGVLAILGFSKRELTKLL
                     TLENLVILVLSYLVSLLLGPTLYFLAVLAITHLLNLTMEVQWFITVNEIIESLGILVVV
                     FLINVITNGLIISKQSLIEFVNFSRKAEKKIKIRKVRAIIAITALLLSYILCLATVFSS
                     TRNMLLSIGMVPVSLLIIVLVVLGTVFTIRYGLAFVVSLLKENKKRLYRPLSNIIYPKF
                     NYRIATKNKLLTVLGGLLTVTVSVAGMMVMLYAYSLNGIERLTPSAIEYNVESENGQVN
                     VTTILENDQVSLVDVDLLRLNTNPEVTITESGQTIPYFDIINYSDYKELMKAQGRINSI
                     EGSKSLPLLINYYPTEISLGKTFNLGNAYDVTVKQVSTHNVFSFSTSVTTLVVSDKLYA
                     KLSSCFPEKEMTIRTFNGNSIRSSEAFYNQFSMVPDVISSYSKEYTVKTANIATYIFIT
                     FLSILFIICTGSILYFTSLIEIMENKEEYGYLSKLGYSKKMIHRILRYETGILFLIPVF
                     IGIVNGGMLLIYYKYLFMDTLVAGNIIMLSLLLCLLFFLIIYGTFYVLTLRSVTSIIKN
                     "
     gene            complement(7145..7882)
                     /locus_tag="ETT65_RS08225"
                     /old_locus_tag="ETT65_08215"
     CDS             complement(7145..7882)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000812013.1"
                     /locus_tag="ETT65_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08215"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_063629199.1"
                     /transl_table=11
                     /translation="MNQLLLKNVCKRYPNQPNYALDHINLTVRKGEFVAVMGRSGSGKT
                     TLLNVTSIIDKIDSGSIYCADKEISAFSDNEATSFRKNDIGFVFQDYMLLDSLTIRENI
                     SVALSLKNIDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKEPEII
                     FADEPTGALDLKSSEETMMILSEINKTEKVTILMVTHDVLSASYADRVILLKDGKLHME
                     IDKKDCGESFYDVISQALSDRGE"
     gene            complement(7879..10023)
                     /locus_tag="ETT65_RS08230"
                     /old_locus_tag="ETT65_08220"
     CDS             complement(7879..10023)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887183.1"
                     /locus_tag="ETT65_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08220"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_136128096.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.7e-22, bitscore:
                     75.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDIPETYFKLKQQVNLGRN
                     GLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRDDAFTIVDPAV
                     GKYVLAKNEFFELSPKFYTEFFYDKATNSSKKIAKRGLVGRNVKEMIFVNRKDTFLTIL
                     YTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFQGGFYFLKNISLVK
                     LQNKFHSTISEKFVTKLLKLPIEYIGKIDKTDIIHRYNGLMIVRELLSERIISIWLDII
                     LMFASISYITYVSTPLGVILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKNSLQTFFSL
                     MDGLFLFKAKNSEKELLSKWDKSFKDYINSTYDRNRYFNLLGAVNYVITFSIPILLILL
                     FLYYSPNSSSGELILLYMMVLNFINPINNILNSIDEILYGVKHYERVLEISTLDDETNG
                     TYKLSEDTDIEINLENINYQYELNGAEVLNGINLKVHSGEFVAIIGKSGSGKTTLAKML
                     LGYVSPSSGDITYNNTSYSKIDKTDFRNISAFVSQDSPIFDGDVMYNISLGRESVSGEQ
                     VIETCKRVSLYEDIRSMPMKFHTPLFRDNPSLSGGQKQRISLARELVTTPRILVLDEPT
                     SALDVKTERIIQKNVEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGSHHCLYKNN
                     EYYRDLYDSYMNNYQEEGIK"
     gene            complement(10001..12835)
                     /gene="lanM"
                     /locus_tag="ETT65_RS08235"
                     /old_locus_tag="ETT65_08225"
     CDS             complement(10001..12835)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /locus_tag="ETT65_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08225"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_136128097.1"
                     /sec_met_domain="DUF4135 (E-value: 1.5e-82, bitscore:
                     274.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-78, bitscore:
                     261.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRNELKLEYQQHQFYEYVNSIFYYDILDTSISENIYLLREKTH
                     KLFYSEFENQLFETIMFLSMKTLVLDINHFSKEIENKSKAYEQYIQQIREENGIGNFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNITESLSNVEFSLGDSHSQKQ
                     TVVKIEFKGKSVYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLIKADYCWQLGVAY
                     TSSNKDEVAKIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLNVQN
                     QNFEGITVDTYQRIYKTSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELINKNRG
                     DMKLVKTDYFQEDGYNIPTLNGKVVEPLDYANEVIAGFRECYTFLMSQRAKVKKILEDF
                     PKLKTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILHESKHIEQFIVVSEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTVIGNLGETTSLFDNIATLNDERMKFTCEFLGIVLKKP
                     IKHWEREKGKSYQFLSISSEHNFSEEILDSIRRIFIDADKNSFSSEEEITWLNIDITET
                     EQWVISPQNITLYNGLIGNALGYLYAYQILGEEQYLVSLNKILKTLETTKNLIETSDMS
                     VFLGKGGLIYLYFSLWKRLKLPQYQKLYLDIIKEFSSQSLEEQNIDYISGVSGLLVVLC
                     NIYNVEQNKTVYYLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGLSHGQSGIAYAL
                     LLSWKINKNYNYFKIAKSAIDFENTRISDGNWIDFRNKGKRSELGMPEPIYWCHGATGI
                     GLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNMELFMNLDDSLKNE
                     VDIEGIILNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQLLRYISNYEVPSLLLLD
                     VPKGSIENEKDYTD"
     gene            complement(12917..13072)
                     /locus_tag="ETT65_RS08240"
                     /old_locus_tag="ETT65_08230"
     CDS             complement(12917..13072)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="ETT65_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08230"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002982773.1"
                     /sec_met_domain="L_biotic_A (E-value: 7.4e-19, bitscore:
                     64.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 5.6e-06, bitscore:
                     23.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFMKNSKDILTNAIEEVSEKELMEVAGGKKGSGWFATITDDCPN
                     SVFVCC"
     CDS_motif       complement(12986..13072)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /locus_tag="ETT65_RS08240_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12917..12985)
                     /prepeptide="core"
                     /locus_tag="ETT65_RS08240_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2306.6"
                     /monoisotopic_mass="2305.1"
                     /core_sequence="KKGSGWFATITDDCPNSVFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /leader_location="[12985:13072](-)"
                     /alternative_weights="2324.6"
     gene            complement(13576..14982)
                     /gene="lacG"
                     /locus_tag="ETT65_RS08245"
                     /old_locus_tag="ETT65_08235"
     CDS             complement(13576..14982)
                     /EC_number="3.2.1.85"
                     /GO_function="GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290548.1"
                     /locus_tag="ETT65_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08235"
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="WP_136076066.1"
                     /transl_table=11
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYT
                     AEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECH
                     KRHVEPFVTLHHFDTPEALHSDGDFLKRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGP
                     IGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDGGYSGEIGVVHALPTKY
                     PFDANNPDDVRAAELEDIIHNKFILDATYLGKYSVKTMEGVNHILEVNGGELDLREEDF
                     AALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDV
                     PKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVK
                     KHLEVISDAISDGVNVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWY
                     KKVAETQVIE"
     gene            complement(15070..16767)
                     /locus_tag="ETT65_RS08250"
                     /old_locus_tag="ETT65_08240"
     CDS             complement(15070..16767)
                     /EC_number="2.7.1.207"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA]"
                     /GO_function="GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263057.1"
                     /locus_tag="ETT65_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08240"
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="WP_136096250.1"
                     /transl_table=11
                     /translation="MNGLIAQIEKGKPFFEKISRNIYLRAIRDGFIAGMPVILFSSIFI
                     LIAYVPNAWGFHWSKDIENLLMTPYNYSMGILGLFVAGTTAKALTDSMNRSLPSTNQIN
                     FMSTMLAAIVGFLLMAANPAKEGGFLTGFMGTKGLLTAFIAAFITVNVYKACVKNNVTI
                     RMPEEVPPNISQVFKDLIPFTLSVALLYVIELIVHTTLGVNVAESIGKLLAPLFQAADG
                     YVGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAETNLQLLQAGEHADKILTSGTQ
                     MFIVTMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPLVLNPIF
                     FIPFILAPIVNVWIFKFFIDTLGMNSFTANLPWTTPAPLGLILGTNFQVLAFILAALLI
                     VVDVIIYYPFLKIYDEQILAEEAAGTNSSDALKEKVAANFDTKKADAILEKSAAKETKE
                     ITDQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILPQYQLVILAP
                     QVASNYEDMKVETDKLDIKLAKTEGAQYIKLTRDGQGALDFVKAQFEN"
     gene            complement(16767..17084)
                     /locus_tag="ETT65_RS08255"
                     /old_locus_tag="ETT65_08245"
     CDS             complement(16767..17084)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /locus_tag="ETT65_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08245"
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="WP_002982760.1"
                     /transl_table=11
                     /translation="MNREETTLLGFEIVAYAGDARSKFLEALKAAQEGDYAKAEELIAA
                     GSDCLNDAHNAQTSLLQKEAAGDDLAYSVTLMHGQDHLMTTILLQDLMKHMIELYKRGA
                     K"
     gene            complement(17108..18091)
                     /gene="lacD"
                     /locus_tag="ETT65_RS08260"
                     /old_locus_tag="ETT65_08250"
     CDS             complement(17108..18091)
                     /EC_number="4.1.2.40"
                     /GO_function="GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768297.1"
                     /locus_tag="ETT65_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08250"
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="WP_014407847.1"
                     /transl_table=11
                     /translation="MTITLTENKRKSMEKLSVDGVISALAFDQRGALKRMMAQHQTKEP
                     TVEQIEELKSLVSEELTPFASSILLDPEYGLPASRVRSEEAGLLLAYEKTGYDATTTSR
                     LPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDVNEQKKAYIERIGSECRAEDIPFYL
                     EILTYDEKISDNASPEFAKVKAHKVNEAMKVFSEERFGVDVLKVEVPVNMKFVESFADG
                     EVLFTKEEAAQAFRDQEASTDLPYIYLSAGVSAKLFQDTLVFAAESGAKFNGVLCGRAT
                     WAGSVKVYIEEGPQAAREWLRTEGFKNIDELNKVLDKTASPWTEKM"
     gene            complement(18095..19024)
                     /locus_tag="ETT65_RS08265"
                     /old_locus_tag="ETT65_08255"
     CDS             complement(18095..19024)
                     /EC_number="2.7.1.144"
                     /GO_function="GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379688.1"
                     /locus_tag="ETT65_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08255"
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="WP_023609980.1"
                     /transl_table=11
                     /translation="MILTVTLNPAIDVSYPLDELKCDTVNRVVDVTKTPGGKGLNVSRV
                     LNDFGETVKATGCVGGESGDFIINHLPDSILSRFYKISGDTRTCIAILHEGNQTEILEK
                     GPMLSVDEIDGFTHHFKYLLNDVDVVTLSGSLPAGMPDDYYQKLIGIANLNGKKTVLDC
                     SGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFKALKAVLQDELFEGIEWIIVSL
                     GADGVFAKHKDTFYNVDIPKIKIVSAVGSGDSTVAGIASGLANDEDDRALLTKANVLGM
                     LNAQEKTTGHVNMANYDKLYQSIKIKEV"
     gene            complement(19072..19587)
                     /gene="lacB"
                     /locus_tag="ETT65_RS08270"
                     /old_locus_tag="ETT65_08260"
     CDS             complement(19072..19587)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /locus_tag="ETT65_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08260"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_023612880.1"
                     /transl_table=11
                     /translation="MKIAVGCDHIVTYEKIAVVDYLKTQGHEIIDCGTYDNVRTHYPIF
                     GKKVGEAVASGEAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNANVI
                     GFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNNPHFFDEFLEK
                     WDRGEYHD"
     misc_feature    19553..19568
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.35"
                     /tool="antismash"
     gene            complement(19622..20050)
                     /gene="lacA"
                     /locus_tag="ETT65_RS08275"
                     /old_locus_tag="ETT65_08265"
     CDS             complement(19622..20050)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982747.1"
                     /locus_tag="ETT65_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08265"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_011529004.1"
                     /transl_table=11
                     /translation="MAIIIGADKAGQELKEVIKDYLKEGKYEVVDVSENEVRDFVDTTL
                     AVAKEVNASEDNLGIVIDAYGVGSFMVATKIKGMVAAEVSDERSAYMTRGHNNSRIITL
                     GSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC"
     misc_feature    complement(20036..20051)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.28"
                     /tool="antismash"
     CDS             complement(20151..20243)
                     /gene="allorf_1624812_1624904"
                     /locus_tag="allorf_1624812_1624904"
                     /protein_id="allorf_1624812_1624904"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKKINIFCLFFIKINKKMLTFMFGGCMIRS"
     CDS_motif       complement(20169..20243)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKINIFCLFFIKINKKMLTFMFGG"
                     /locus_tag="allorf_1624812_1624904_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(20151..20168)
                     /prepeptide="core"
                     /locus_tag="allorf_1624812_1624904_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.10"
                     /molecular_weight="590.8"
                     /monoisotopic_mass="590.3"
                     /core_sequence="CMIRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKINIFCLFFIKINKKMLTFMFGG"
                     /leader_location="[20168:20243](-)"
     misc_feature    20203..20216
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(20204..20217)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     gene            20496..21269
                     /locus_tag="ETT65_RS08280"
                     /old_locus_tag="ETT65_08270"
     CDS             20496..21269
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004270277.1"
                     /locus_tag="ETT65_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08270"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_002982738.1"
                     /transl_table=11
                     /translation="MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLAD
                     KGLLIRTHGGAQYLDYSSAKDEGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGETVFIG
                     PGTTLEHLAVELKNRNIRVITNSLPVFLILHPSTTIDLILIGGECREITGAFVGAIAIN
                     NLETLTFSKAFVSANAVYNNSIATYSDLEGEVQRVALNNAVEKILLVDSTKFESYDFYN
                     FYQLDQVDLIVTDKNVTTDIIEKYKKFSKIIIADK"
     misc_feature    complement(21838..21856)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            21930..22217
                     /locus_tag="ETT65_RS08290"
                     /old_locus_tag="ETT65_08280"
     CDS             21930..22217
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255538.1"
                     /locus_tag="ETT65_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08280"
                     /product="DNA-damage-inducible protein J"
                     /protein_id="WP_002988079.1"
                     /transl_table=11
                     /translation="MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVV
                     VTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQGKFYTSEEVRAELGL"
     gene            22207..22542
                     /locus_tag="ETT65_RS08295"
                     /old_locus_tag="ETT65_08285"
     CDS             22207..22542
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048651.1"
                     /locus_tag="ETT65_RS08295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_08285"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_002982731.1"
                     /transl_table=11
                     /translation="MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDI
                     EKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKDYIVLYHIEGEENRVVIDYLLPTQS
                     DYIKLFK"
ORIGIN
        1 aagtggagct attaatcaag caattttagc cattattcct gagaaaaaat attcttctct
       61 ttttataaaa aattggttat ataaacaaaa atcctcaatt attgagaaat atttacaagg
      121 tggccaagga aatttatctg gttctattgt taaagaatta actattcatt tcccttccct
      181 ccccgaacaa gaagctattg gcgagctctt ccaaacggtt gatcaactgc ttcagttaca
      241 ggatcaaaag ctagcaacac taaaagaaca aaagcaaacc ttcctcagga aaatgttccc
      301 agctcaagga caaaaagtcc ctgaaatccg tttacaaggt tttgatggtg agtgggaaga
      361 gaagaaattg ggggagatat ctcggatgtt ttcaggtggc actcctaacg taggtatccc
      421 tgaatactat aatggtaata ttcctttcat tagatctgct gagatcaaca gtgatcaaac
      481 agaattatct atcacagaca aaggtctatc aaattcatca gcaaaattag tggaaaaaaa
      541 tacattatta tacgctctct acggtgcaac tagcggagag gttggacttt caagaataag
      601 tggagctatt aatcaagcaa ttttagccat tattcctgag aaaaaatatt cttctctttt
      661 tataaaaaat tggttatata aacaaaaatc cttaattatt gagaaatatt tacaaggtgg
      721 ccaaggaaat ttatctggtt ctattgttaa agaattaact attcatttcc cttctctctc
      781 cgaacaagaa gccattggta atttcttcca aactttagac caacaaattg ctcaatctga
      841 agaaaaacta acagaactca aagcactcaa acaaacatta ctcaatcgtt tattcgtata
      901 agaaaggacg cacatggcag agaaaacaac ttcactccgg caagcactat ggcattcggc
      961 cgaccaatta cgtggccaaa tggatgccaa tgactataaa aactatcttc ttggacttat
     1021 tttttacaaa cacttatctg ataaattact cttggctgtt tgtgataatc tagaaaaaca
     1081 cttcaatacc tttacagagg ctcaaaaaat ctttgaagat gcttatcaag atgaagacct
     1141 aaaagatgac ctcatttctg ttgttactgg tgatttaggt tactttatcg aaccgacact
     1201 gacctttgaa aaactcatcc aagatgttta tcacaatact ttccaattag aatcattagc
     1261 tcaaggtttt cacgatattg aacaaaatgg tgaagacttt gaaaacttat ttgaagatat
     1321 tgacctctac tctaaaaaat taggctctac tcctcaaaaa caaaatcaaa ccattgccaa
     1381 tgtcatgaaa acattaaatg aaattgactt tgaggcagta gatggggata ctttaggcga
     1441 tgcttatgag tacttgattg gtgaatttgc cagtgagtca ggaaaaaaag caggtgagtt
     1501 ctatacccca caagctgtct ctcacttgat gactcagatt gtctttttaa gttgtgaaga
     1561 tcaaaaagga atgaccctct atgaccctgc tatgggatct ggatcactcc ttttaaacgc
     1621 taagaaatat agtaaccaat ccgataccgt ttcttactat ggtcaagaaa tcaatacttc
     1681 tacttataac ttggctcgta tgaacatgat gcttcatggc gttgccatcg aaaaccaaca
     1741 cttaagtaac gctgatacct tggatgcaga ctggccaaca gatgaaccaa ccaactttga
     1801 tggggtattg atgaacccac cttattcttt gaaatggtca gcgactgctg gtttcttaac
     1861 agatccacgt ttttcaagtt atggtgtatt agcaccaaaa tcaaaagctg actttgcctt
     1921 tttacttcat ggtttctatc atttaaaaaa tacaggaact atggcgattg tcttaccaca
     1981 cggtgttctt ttccgtggag ctgcagaagg caagattcgc caaaagctac tcgaacaagg
     2041 ggctatcgat accattatcg gactcccatc aaatatcttt tataatacaa gcatccctac
     2101 gactattatc atattaaaga agaacagaac caacaaagat gtcttcttta tcgatgcttc
     2161 aaaagagttt gataagggca aaaatcaaaa cacaatgaca gatgaccata tcaagaagat
     2221 tcttgacgct tataagagtc gtgataattc tgataagttt tcgtacttag cctcatttga
     2281 tgaaatcatt gaaaatgact ataacttaaa tatcccacgc tatgttgata cctttgagga
     2341 agtcccagtt aaaccactgc cagaattagc taaacagctc agtgacattg atcaagaaat
     2401 tgccaaaaca aatgccaaac tagatcaact catgaaacaa ctagtcggaa caaccaaaga
     2461 agcacaagac gaattggata cttttagaaa ctaaaagaca aaaaaaacac cacagtagat
     2521 gattactact gtggcgtttt atttaaaatt gagtagtgaa cctttattga gtacttatca
     2581 tacaagattc tccttcttca cctataaatc aaaatagaat catctcatct aactttgtcc
     2641 gttttctttg ttttatttaa aatagttatt tgaagttaca atgatttctc aaacgtttag
     2701 aaagcttaaa cacggttaag agaaattttc aggacaactt ttgatccttc cacaaaaacc
     2761 atggcgcgaa ccataaagta gttccaatcg ttgatatata agcatatatt aacgttctgg
     2821 gagttgtgaa gctttacgag tttttttaga cctggtttaa acaacttttg tttgactaaa
     2881 tttaaaaagc ttttcatatc aggcatttcc ctacttttta taaaagcgtt atctcaatca
     2941 atttcaatca aaaagaactc aaaaacaatg agtttaaatc tgggtattta acaggaaatc
     3001 cctagcaacg acacaagtaa aacttatgtc gtttgattat ctgcaactca gaaatccata
     3061 aaatacccta attgttcggc tttgtagata gcctcttgct tattatttac caaaagcttt
     3121 gagtagatgt gggtcaaatg attaaatact gttctcctac taatttgtaa cgtttcctct
     3181 atttctttta tagagaatcc tttcttactc aaatttaaga tagctatttc ctggtcagtt
     3241 aaagattcaa cataatcctg agattcgatt tgttcaaaat acttttttcc agaatccact
     3301 ttttttaaga tagaaatgag ttgtttaggg tctatatttt tatctacaaa accgtatgct
     3361 cctacttttt ttgccctctc tctatagatt gatttaacat atcctgtcaa cataacaact
     3421 ttcaaatgag gagtagactg tatgagttct tttgctatct ccaatccatt ttctttagaa
     3481 atatttgtta aattaatatc aagcaatata atatcgtact tagacaaatc aatcgtcaca
     3541 tcgttaaaat gagaagtaat cgtatctatg acatctactt catcatactg ttggaataac
     3601 agttggatac tctttgcaaa tagtctgtgg tcatcaatta ataaaatctt cataacacaa
     3661 tttccaatct atgggaagta atattctgat agtaaattgt ttagtatcca tttgtagttc
     3721 tagatctcca tcaaaagctg ctagtgtttc ttgaaatgat ttcaatcctc tgccataatt
     3781 tatagagtgt actttttcca ctacttgatt gctctcctca atgataataa tatcagattg
     3841 aatcgttaaa gataaacgaa tgtcttttcc atctccatat tttatagcat tgtttattag
     3901 ctcttttata aacctataaa caatatctcc atatggggat ggcactacca tattatctga
     3961 acagttaaaa tacaataagg tattactttt tctactttta acaatatcat caaaaagaga
     4021 ctgtatgttt tctttcattg tttgattagc gggaactatt gggtggtaag tatccatttc
     4081 atctctgata ccagaaacta aatcattcaa ctcattaaca ataaaaccat gtgttatatt
     4141 actattttct agagaaagca agttttttat cgctatgata ttttgtaaaa catcatcatg
     4201 caaataattt gagaactcca ctctcatgtt ttcctctgat ttcataaaat agttcagtct
     4261 tctattttca tagtcaaaat tttgtttgga gttttctaaa taataaaaga tgcaagaaat
     4321 taccactaga caaaataacg tgcttgcgtc aacaattata aaaaataata aaaaatcttt
     4381 aactaatacc ttcatgagta caatccaaca aaggataaga agtagaaata atagttctat
     4441 acgagctttg taatcaccta accatctttg ggtaacaaaa ctcaatttat catgtatggt
     4501 cttaaaatag tatattacac tcattataag gggaaacaga taccatccca aattattaaa
     4561 ggcttgatta acatctagca tttctccata aagttcacta ccaagtatta ccagcaaaag
     4621 taaagaaaat agtatcaatg aacgtctaac aactgatatt tgttgcctaa aggacctata
     4681 atatagcact ataactagta acggatacag gtgtaaaata gtaaaaacca tcaggaataa
     4741 aaaattaaat aaaattctat taacaaaaag gctagttata gaaacaaaaa taattattaa
     4801 caagccctta tctaacttat ctttaaattg tttgtgccca tataatatta aattagtaat
     4861 ctcaacggta taacaataga gcaatataat ctgtagtcca ctgcttaaaa agagaggagt
     4921 tcctcttatc agcacagata ctaagtattg ccaaattgtt aacgagatga tagaaataat
     4981 ccttttaaaa atatcatctt gtttttggcg taatattact gccagccaaa taaaagctgc
     5041 atcaataaga gtcattacaa gagctacttt ttcagagaaa agcagagaca agttctttcg
     5101 atgataaatc aaaatcaaca aggctattaa ttgttgcaac aagattattg cagtcccaaa
     5161 gaacttactc tttgttatgt tttttattct tatcatatta tttacttaat cgttaaagtt
     5221 aaaagatttt taaaattaat ttttgattat agatgtcact gaccgcaatg tcaatacata
     5281 aaatgtgcca tatattatca agaagaaaag cagacaaagc aataaagata acattatgat
     5341 attgcctgct accaatgtat ccatgaataa atatttatag taaataagca acataccacc
     5401 atttacaatc ccaatgaata caggaataag gaaaagtata cctgtttcat atcgaagaat
     5461 ccgatgaatc atttttttac tataacctag cttacttaga tagccatatt cttctttatt
     5521 ttccatgatt tcgatgaggc ttgtaaagta cagaatacta cctgtacaaa taataaagag
     5581 tatggatagg aaagttataa agatataagt cgcaatatta gcagtcttta ctgtgtattc
     5641 cttactataa ctactgataa catcaggaac catactaaac tgattgtaaa atgcttcact
     5701 tgacctaatc gaatttccat taaaagtcct aattgtcatt tctttctctg gaaaacaaga
     5761 actaagttta gcatataatt tatcagaaac aaccaaggtc gtgacacttg tagaaaaact
     5821 aaaaacatta tgcgttgata cttgttttac agtaacatca tatgcatttc ctaagttaaa
     5881 ggtttttcca aggctaattt ctgttggata ataatttatt aacaatggga gtgacttact
     5941 accttcaata gaatttattc tcccttgagc tttcattaac tctttataat cactgtaatt
     6001 aattatatca aaataaggaa ttgtttgccc agattctgtg atagttactt ctgggttagt
     6061 gttcaatctc aataggtcaa catcaaccaa gctcacttgg tcgttctcta aaatagttgt
     6121 aacattgact tgaccgtttt ctgattcaac attatattct atggcagatg gagtcaacct
     6181 ctctatccca ttaagagaat aagcatagag cattaccatc attccggcaa ctgaaacggt
     6241 tactgttaaa agacctccca agactgttaa taatttattt tttgttgcaa tacgatagtt
     6301 aaatttggga tagatgatat tagacagagg acggtataac ctttttttat tttcttttaa
     6361 caacgaaact acaaaagcca atccatatct gatggtgaac actgttccta aaacaactaa
     6421 gacaattatc aatagagaaa ccggtaccat ccctatgctt aatagcatat ttcgtgtgga
     6481 tgaaaacact gtcgccaaac ataaaatata tgacaatagc aatgcagtga tagcaataat
     6541 agctctgact tttcttatct taattttttt ctcagccttt cttgagaaat taacaaattc
     6601 aatcaaagac tgtttactaa tgataagtcc atttgtgatg acattaatca gaaaaactac
     6661 gactaatatt cctaaagact ctataatctc attaactgta ataaaccact gaacttccat
     6721 tgttaaattc aatagatgag taattgccag tacagctaaa aaatataaag tcggtcccag
     6781 caataaactt accaagtaac tcagaactag aataacaaga ttttctaaag ttagtaattt
     6841 tgttaattct ctttttgaaa accctagtat tgctaagact ccaagctctt gactacgttt
     6901 ttttacaaag aaattattga agtaaattaa gaataccacc aaaaatacaa tcaaaaaaat
     6961 caatgaccca ttagcgataa ctagagcttg accactatcc ccaatttttt ctgtaatgat
     7021 tttatctgag ataaaattta gaaaagctat aaaaatactt aataaaccaa tcgtagctag
     7081 aaaatagata cgatataacg aaaaattttt tttaatgtta gattttgtaa ttgaccaaat
     7141 catattactc tcctctatcg gataaagctt gactaattac atcgtaaaac gactctccac
     7201 aatctttttt atcaatctcc atgtgaagtt tcccatcttt gaggagtata actctgtcgg
     7261 cataagaagc tgataaaacg tcatgagtaa ccattaaaat agttaccttt tctgttttat
     7321 tgatttcact caaaatcatc attgtttcct cagaagattt caagtcaagt gctccagttg
     7381 gttcgtcagc aaaaataatc tctggttctt taatgattgc tctgataata ctgaccctct
     7441 gtctttgacc tccagaaagt tgatacggat atttcttcaa ctgttcatat aaattaaatc
     7501 tttttgcata gctatttatc aaatcatcaa tctttgaaga atcaatattt tttagagaca
     7561 aagcaacaga aatattctcc ctaatggtta gactgtctaa cagcatataa tcttgaaaaa
     7621 caaaaccaat atcatttttt ctaaaactag ttgcctcgtt atcagaaaat gcactaattt
     7681 ctttgtctgc acaataaata ctcccactat caattttatc aataattgaa gtaacattta
     7741 aaagtgttgt ttttccacta ccactacgtc ccatgacagc tacaaattct ccttttctaa
     7801 cagtcaaatt gatatggtct aaagcataat tcggttggtt tggatacctt ttgcaaacat
     7861 ttttcaatag taattgattc attttatccc ttcctcctga tagttgttca tgtacgaatc
     7921 atataaatca cgatagtact cattattttt atataaacaa tgatgactac catagtcaat
     7981 aattttccca ttatccatta ttaaaatctt atcagctttt tcaactgtat taagtctatg
     8041 ggtaaccaaa accctcgtac aatgtaaagc ctcaacattt ttttggatta ttctttcagt
     8101 ttttacatct aaagctgatg taggttcatc aagaactaag attctagggg tagttactaa
     8161 ctctcttgct agagaaattc gttgtttttg ccccccagat agtgatggat tatctcgaaa
     8221 aagtggagta tgaaacttca ttggcatact cctgatatcc tcatatagtg ataccctttt
     8281 acaagtttca ataacctgtt ctcctgaaac agattctctc cctagcgaaa tgttatacat
     8341 cacatcccca tcaaatatgg gagaatcttg agatacaaaa gccgatatat tcctaaaatc
     8401 agttttatca attttagagt aggatgtatt gttgtatgtg atgtctccac tactagggct
     8461 tacatagcct aacaacatct tagctagagt tgtctttcca cttccacttt tccctataat
     8521 tgcaacaaat tctcctgaat ggacttttag gtttattcca tttaacacct ctgccccatt
     8581 taactcatat tgatagttta tattttctaa atttatctct atatctgtat cctctgatag
     8641 cttataagtg ccattcgtct catcatcaag agttgatatc tctaataccc tttcgtaatg
     8701 cttaacacca tatagaatct catcaatcga attcaaaata ttattaatgg gattaataaa
     8761 atttaaaacc atcatataaa gaagaataag ctcaccactg ctactatttg gtgaataata
     8821 tagaaataac agaattaaca aaataggtat ggaaaaagtt atcacataat ttactgctcc
     8881 taaaagattg aaatatctat ttctatcata tgttgaattg atatagtcct taaaactttt
     8941 atcccatttt gacaaaagtt ctttttcaga atttttagct ttaaaaagaa atagcccgtc
     9001 catcagtgaa aaaaatgttt gtaaagagtt cttttgtctt aaaacttctt tacctaactt
     9061 ttcttgttta atgcttagtg ataggaaaaa aatcatcatt tctacaataa aaactatacc
     9121 caatataact cccaaaggtg tagaaacata tgtgatataa ctaatactcg caaacattaa
     9181 gataatatcc aaccaaatag aaataattct ttctgatagt aactccctca caatcatcaa
     9241 accattatat ctatgaatga tgtctgtttt atctattttt ccaatatatt ctatgggaag
     9301 tttcaataac ttagtcacaa acttttctga aatagtgctg tgaaatttat tttgcaattt
     9361 cactaaagag atattcttta gaaaataaaa tcctccctga aaaaaaatta ttatagaaag
     9421 taggactgca ctttctaaat agccaaactt tttaaggaaa acccaatttc catcaataat
     9481 tccccttata aaaaatggaa ttgacactgt gataatctga aaaatcagag tatatagaat
     9541 ggttaaaaaa gtatccttcc tatttacaaa tatcatttcc tttacgtttc tgccaactaa
     9601 tcctcgtttg gctatttttt ttgaagaatt agtcgcctta tcataaaaaa attcggtata
     9661 aaatttagga gataattcaa aaaattcatt ctttgctaag acatatttcc caacagcagg
     9721 gtcaacaata gtaaaggcat catcacgaat atcctctaaa attacaaaat gcgaatctga
     9781 aacaaatacc atgacaggta agttttcggg atatttggaa aaacgataag tcttacaagt
     9841 aactccgtag atagaagcaa tatctgagat attctttata ctcagtccat ttctccctaa
     9901 attgacttgt tgtttcaatt taaaatatgt ttctggaata tcaaaataat ctaacatcat
     9961 atataaacaa cataatccac attcagtagg agttgtttgt tcaatcggtg taatcttttt
    10021 cattttcaat actccctttt ggaacatcta ataacaataa tgatggtact tcataattgg
    10081 atatatatct aagtaactgg tatgctatcc ctatttcacc aaccatcata ttaaacactc
    10141 ttgtgtgttg tggcaagcca gattcccaac caaatttttg agaattacga acaatattaa
    10201 gtatgatacc ttctatatct acttcatttt tcaaggagtc atctaaattc ataaataatt
    10261 ccatgttgcc cattttcccg tgacaaaggc aatccgaatt caaataacca ttatttaata
    10321 ccgtttgttt agccatttca taattatttt tcaactcttt atcgtttaac cattttgatt
    10381 ctctatatct cgttaatccg atacctgttg caccatgaca ccaataaata ggttctggca
    10441 ttcctaactc tgaacgtttt cctttatttc taaaatcaat ccaatttcca tcagaaatac
    10501 gggtattttc aaaatcaata gctgacttcg ctattttaaa ataattataa tttttattga
    10561 ttttccatga taaaagtaat gcatatgcaa tcccagattg tccgtgagat agtccattta
    10621 gaatttctga atctgaaaaa tccgataccc aataaacctt atcatcttct tttttcacat
    10681 tatcaataat aaattcagat atcctattaa ttaaataata tactgtttta ttttgctcta
    10741 cattatatat gttgcacaga acaactaata aaccagacac tccagaaata taatctatat
    10801 tttgctcctc tagtgactgg ctggaaaatt ctttgattat gtctaaatat aatttttggt
    10861 attgaggtaa tttaagtctt ttccacaaac taaagtatag ataaatcaaa cctccttttc
    10921 ccaaaaaaac tgacatatca ctagtttcta taagattctt tgtggtttcc aatgttttca
    10981 atatcttatt taatgatact agatattgct cttcaccaag aatttgataa gcatataaat
    11041 aacctaaggc attcccaatc aatccattat acaaggttat gttctgagga gatattaccc
    11101 attgctcagt ctctgtaata tcaatattga gccatgttat ctcctcctct gaagaaaagc
    11161 tattcttatc tgcatcaata aatattcgtc taatgctgtc taagatttcc tcactaaaat
    11221 tgtgttctga ggagattgat aaaaactgat aagatttgcc cttttccctc tcccaatgct
    11281 taatcggttt tttcaagact attccaagaa attcgcaagt gaacttcatt ctttcatcat
    11341 tcagggtagc tatattatca aataatgagg ttgtctctcc tagatttcca attactgttc
    11401 ctaaagaatt atatacattt ccactggtat ccattgaaaa gtaaggaata tcaccattca
    11461 tcaaatcttt aatttcacta acaacaataa attgttcaat atgttttgac tcatgtagta
    11521 tcgaaaataa attctccctc tttttttctg agaaaagata tttgggattc gtagaggctt
    11581 gtaaaaattt tccatagtcg gaagtatttc tgaatatggc tctagttttc aattttggga
    11641 aatcttctaa aattttttta acctttgcac gttgcgacat gagaaatgta tagcattctc
    11701 taaaacctgc aattacctca ttagcatagt cgagaggttc caccactttc ccatttaatg
    11761 tcggaatatt ataaccatct tcctgaaaat agtcagtttt cactaacttc atatctccac
    11821 gatttttatt tatcagttca tactttccct tttttctttt cccacctttt ccacttatcc
    11881 cagaaacgtt aggagcgctg tttttctcaa attgtacagg aaataaacca tttgaaagtg
    11941 atgtcttata aattctctga taggtgtcta cagtaatccc ttcaaaattc tgattttgta
    12001 cattcaactt tctttgaaaa aaggtttcaa cgtcaattaa atataaatct ccgcctgaaa
    12061 caatcacatt ttccatatgt aagtccgtaa tagaaaatat ttcagaaaat gctgctaaaa
    12121 caccatactt aaagtaaatt tttgctactt catctttatt ggaacttgta taagctacac
    12181 caagttgcca acaataatcc gctttaatta agctttcagg aagactgaac gaaggtatat
    12241 tattagattt caatagacta ataagttcca acaagatgtt gtatgaatca tagcttttag
    12301 gcttgtagta aacggatttc cctttaaatt caatcttaac gactgtttgt ttttgggaat
    12361 gactgtctcc aagtgaaaat tcaacattac ttaaggactc agtaatatta aagcatgacc
    12421 ttatttcaga caaatctttt aaaaacctat caaatagcaa agagtatgat tccactacca
    12481 atccaacttc tctattgatt tgttttagca aatatggata tctgtcaaaa aaattaccta
    12541 tcccattttc ttcccttatc tgctgtatat attgttcata tgcctttgac ttattttcaa
    12601 tttccttgga aaaatgattt atatctagaa ctagtgtttt cattgaaaga aacatgatcg
    12661 tttcaaataa ctgattttca aactcactat aaaataactt atgtgtcttt tcccttaaca
    12721 aataaatatt ttcactaata gaagtatcta atatgtcgta ataaaaaatt gagttaacgt
    12781 attcgtaaaa ctgatgttgc tgatattcta actttaattc atttcttttt atcatttttt
    12841 cctaccacta cttaaaaatc ctgcctagac taagtctaaa caggaaattt tagtctgctt
    12901 atccagattg ttttaattaa caacaaacga atactgagtt cggacagtca tcagtaatag
    12961 ttgcaaacca accggaacct tttttaccac cagctacttc cataagttct ttttcagaaa
    13021 cttcttcgat agcattagtc aaaatatcct ttgaattttt cataaaactc attctccttt
    13081 ctatcagtat gtagtgacta ttttctacac ttttattgta aataatacgt cttcattttc
    13141 aatgagtaaa aagtgcaaaa atgacttttt taatattttt tagtaagatt tttgagatgt
    13201 cacataagag gtcactttat aacaaatagc cctctgatat aaaaaaacaa aactcgttct
    13261 ttacagctat tttacaatct aatcgcttct cgttataaca tcaatctcta atcagaaaat
    13321 ggttacttta cttatttaat caggtcagga gtttgaatga cagaagtcaa atatctgaaa
    13381 aaggatgtta aataaaactt tcaaaaccca ttttcatcaa ctaaaaacac ttataacccg
    13441 atcttacaac taatggatta ccatcaacag caaataatac tatgcttgaa aaatgtcaac
    13501 atcatctact ttttgtgact ataattcagt aaacgaacat gacgtgtaaa aatgtattaa
    13561 agcagtatct caaaatcatt caatcacttg agtttctgct acttttttat accagtaggc
    13621 actcttctta ggataacgtt cttgagtttc aaaatcaaca tagaagagac cgtaacgttt
    13681 ttcatagcca tttgaccatg aaaagacatc cattaatgac cacatgaagt atcctttaac
    13741 atttacacca tcagaaatag catcagaaat aacttctaag tgttttttca cataatcgat
    13801 acgtccatca tcatagacag tattatctac aaactcatct ttgtaaccaa gaccattttc
    13861 agtgatataa attttcttgt agttaggata atcagcttta acacgcatga tttgatcata
    13921 taagccttgt gggaagataa tccaatccca gtccgttttt ggaacatcaa cgggtgcttt
    13981 tcttcgacca acacccttga tttggtattt agagctgcct ttttcccctt taccattatg
    14041 aatgatttca gtctcaccat caaaagcttg catccaatca ctcatataat agttaatacc
    14101 aaggaagtca ttcaaatctt ttgcagcgtc tagtgcagca aaatcttcct cacgaagatc
    14161 aagttcacca ccattcactt caaggatatg gttaacacct tccattgttt taactgaata
    14221 cttaccaaga taagttgcat caaggataaa tttattatgg atgatatctt caagttcagc
    14281 tgctctaaca tcatcaggat tgttagcgtc aaatggatac ttagttggaa gagcatggac
    14341 aacaccaatt tcacctgaat agccaccatc tttaaagagt ttcacagcgc gagcatgaga
    14401 aaccatcatg ttatgatgtg attggaaaac tttagcaaga tcatattgga tacctggagg
    14461 gaatttacca accaagtatt ggccatcacc aattggtcca atttcgttaa atgttgtcca
    14521 atagttaact tctgagaatt ctttaaaaca gaattctgca taatttacaa aatgttcaat
    14581 gttctcacgc ttgaggaaat caccatccga gtggagagct tctggggtat caaaatggtg
    14641 aagtgtaaca aaaggctcaa catgacgctt atgacactct gcaaagagat tgtggtagta
    14701 ttcaactcct ttagggttaa cttctccttt tcctgttgga aaaatacgag accaggcaat
    14761 agagatacgg atgccgttga caccaaattc ttcactaagt ttcaaatcga cagggtaacg
    14821 attataaaaa tcacttgctg gctcagctgt gtaccaatag ttgtcttcta agtatttatc
    14881 ccaagctact ggtcctttac catctgtgtg ggtagcgcct tcagcctggt aagcagctgt
    14941 agcaccacca aaaataaaat ctttaggtaa tgttttagtc atctcagttt ctccttgaat
    15001 atctttcaaa aataaagttc ccaaaacaat ttttgtgttt gagaacttta cgacatttaa
    15061 actgttttct taattttcaa actgtgcttt tacaaaatca agagctcctt gaccatcacg
    15121 ggtcaatttg atgtattgag ccccttctgt tttagctaat ttaatatcaa gtttatcagt
    15181 ctccactttc atatcttcat agttagaagc tacttgaggt gcaaggataa caagttgata
    15241 ttgtggtaaa atctcacggt gagcaccata acttcctgct gctgcagtga caggtgcacc
    15301 atattcttta gctgctttat tcaaagcatt tgctagtagt ccacttgtac caccaccggc
    15361 acaaagaacg agaacattag tttgatcagt gatttctttg gtttctttag ctgctgattt
    15421 ttcaagaata gcatcagctt ttttagtatc aaagtttgct gctacttttt ctttgagcgc
    15481 atctgatgaa ttcgtacctg ctgcttcttc agcaagaatt tgctcatcat aaattttcaa
    15541 gaatgggtag tagataatca catcaacaac gattaacaaa gctgccaaaa tgaatgctag
    15601 cacttggaag tttgtcccaa ggataagacc caatggagcc ggtgttgtcc aaggtaagtt
    15661 tgcagtgaaa ctgttcattc caagtgtgtc aatgaagaat ttgaaaatcc atacgttgac
    15721 aatcggtgcc aagataaatg gaataaagaa aattgggttc aaaacaagtg gagcaccaaa
    15781 caaaatgggt tcgttaacac caaagaatgt tggaacaaca gatgcacgtc caatggcttt
    15841 gttacgtttt gattttgtta accacatgaa catgaatgga acgacgagag ttgcaccagt
    15901 accacccatg gtaacgatga acatttgagt ccctgaagtc aagatcttat cagcatgttc
    15961 accagcttga agtaattgaa ggttggtttc agcatttgcg taagtaatcg ctgcaatggc
    16021 tggttcaaca atagatggtc catgaatacc aacaaaccag aagaaagcaa atgcaccgaa
    16081 gataatagtg attccaacat aaccatctgc tgcttggaac aatggtgcaa gaagtttacc
    16141 aattgactcg gcaacgttaa cgcctaaagt agtatgaaca atcaattcaa tcacataaag
    16201 cagtgcaact gataatgtaa atggaatcaa atctttaaaa acttgagaga tgtttggtgg
    16261 cacctcttct ggcatgcgaa tagtaacatt gtttttcaca caggctttat agacatttac
    16321 ggtaataaaa gctgcgatga aggccgttaa caaacctttt gttcccataa atccagttaa
    16381 gaaaccacct tcttttgctg gattggctgc cataagtaaa aaacctacaa tagcagcgag
    16441 catggtagac atgaagttga tttggttagt gcttggtaat gagcgattca ttgagtcagt
    16501 taaagctttg gctgtcgtac cagccacaaa caaacctaaa atacccattg agtagttgta
    16561 tggcgtcatc aagagattct caatatcctt actccaatgg aagccccatg catttggaac
    16621 ataggcaatc aagataaaga tacttgaaaa caagataaca ggcataccag cgataaaacc
    16681 atcacgaata gcgcgaagat agatatttcg agaaattttc tcgaagaaag gtttcccttt
    16741 ctcaatctga gcaattaatc cattcattat tttgctcctc tcttataaag ttcaatcatg
    16801 tgtttcatta aatcttgtaa taaaatggtc gtcattaaat gatcttgacc atgcattaaa
    16861 gtgacactat aagctaagtc atctccagct gcttcttttt gtagtagact tgtctgagca
    16921 ttgtgagcat cattcaagca gtcactacct gcagcgatta attcttctgc tttagcataa
    16981 tctccttctt gcgctgcttt aagcgcttcc aaaaattttg aacgggcatc accagcatag
    17041 gctacgattt caaaacctaa aagagtagtt tcttctctat tcattgtagt ttcctccgaa
    17101 aataatgtta cattttttca gtccaaggac ttgcagtttt atctagtact ttgtttaatt
    17161 cgtcaatatt tttgaaacct tctgtacgca accattcacg agctgcttgt ggtccttctt
    17221 cgatatagac ttttacagat cctgcccagg tagcacgtcc acataagaca ccgttgaatt
    17281 tagcacctga ttctgctgca aacaccaaag tatcttggaa caatttggca gaaacacctg
    17341 cactcaagta aatatatggt aaatcagtag aagcttcttg gtcacggaaa gcttgagctg
    17401 cttcttcttt tgtaaagaga acctcaccat ctgcaaagct ttctacaaat ttcatattta
    17461 ctggaacttc gactttcaag acgtcaacac caaagcgttc ttctgagaag actttcattg
    17521 cttcattaac tttatgagct ttaacttttg cgaactctgg gctagcatta tcagagattt
    17581 tctcatcata agttagaatt tctaagtaga atggaatatc ttctgcacgg cattcagaac
    17641 caatacgttc aatgtaagct tttttctgct cgttaacatc ttgatctcca tcaatatcat
    17701 agtaaagaag gaacttaact gcttctgctc cagcttcttt aatacgtttt gcagaccaaa
    17761 catctaagca atcaggtaag cgactagttg ttgttgcatc gtatcctgtt ttctcatatg
    17821 ccaacaacaa gcctgcttct tctgaacgaa cacgacttgc tggcaagcca tattcaggat
    17881 caagtagaat tgaggatgca aatggtgtta gttcttcaga aactaaactt ttaagctctt
    17941 caatttgttc tactgttggc tcttttgttt gatgttgagc catcatacgt ttgagagctc
    18001 cacgttgatc aaaagctaag gcagaaataa caccatctac acttagtttt tccatgcttt
    18061 tacgtttgtt ttcagttaaa gtaattgtca ttttttatac ctctttgatt ttaatagatt
    18121 gatataactt atcgtaattt gccatgttaa catgcccagt tgttttttct tgcgcattta
    18181 acatccctaa gacatttgct tttgttaata aagctcgatc atcttcatca ttcgctaaac
    18241 ctgaagcaat acctgccact gtagaatccc ctgaacctac agcgcttaca attttaattt
    18301 taggaatgtc aacgttataa aacgtatcct tgtgctttgc aaatacacca tcagcaccaa
    18361 gagaaacgat tatccattca attccttcaa atagttcatc ttgtaagact gcttttaaag
    18421 ctttaaaatc ttttgtcatt tctttaccaa gaagttgaga aagttcttca agattaggct
    18481 tgataactgt tggtttacta tcacctttta gtactgcttc tagagcattt ccagaacaat
    18541 ccagaaccgt tttcttacca ttaagattgg caataccgat taacttctga tagtaatcat
    18601 ctggcatacc agcaggcaga ctgcctgaga gcgtcactac gtcaacatca ttcagtaaat
    18661 atttgaaatg atgagtaaag ccatcaattt catctacact taacatcggt cctttttcta
    18721 aaatctccgt ttgattacct tcgtgtaaaa tggctataca agttctagta tcacctgaaa
    18781 ttttatagaa gcgacttaaa atcgaatcag gaagatgatt aatgataaaa tcaccgcttt
    18841 ctccacctac acaacctgta gctttgactg tctcaccaaa gtcatttaga actcgggaaa
    18901 cattcaagcc tttaccaccg ggtgtctttg taacgtctac aactcgattg acagtatcgc
    18961 attttagctc atccaaaggg taggagacgt caatagctgg atttaaagta actgttaaaa
    19021 tcacaatagc tcctttttct atatatatcc ctatagtaat ttattcaaat attagtcgtg
    19081 atattcacca cggtcccatt tttctaggaa ttcatcaaag aagtgtgggt tgttttgatc
    19141 ttggctagca tgttgcaagc tatccatttt ttcaatccat tttttatttt cttcagttgg
    19201 tttgtattcc gcggccaaga aagcatcgat aatatcattc atcaataaac caccgatgat
    19261 ttttccacca aaaccaataa cgtttgcgtt tagctcttct tttgagtaga tagcagatgt
    19321 catatctcta acgagtgctg cacgaatacc gggaactttg tttacagcat ttgtgatacc
    19381 aacaccagta ccacagataa caacacctaa ttctgcttca ccacttgcta ctgcttcacc
    19441 aactttttta ccaaagattg gatagtgtgt gcggacatta tcgtatgtcc cgcaatcaat
    19501 aatttcatga ccttgtgttt tcaaatagtc aacaacagcg attttttcat aagtaacaat
    19561 atggtcacaa cctacagcaa ttttcatttt tattctcctt gttttaacct atttcaatca
    19621 attagcacat tttattaagc atgtcgacac gaacttgatg acgtccacca tcatatttac
    19681 cttcgacaaa gcctttgata atgttctttg caattcctgg agcactaatt tcagaaccaa
    19741 gcgtgatgat tcgagagtta ttgtgacctc ttgtcatgta tgctgagcgc tcatctgata
    19801 cttcagctgc caccattcct ttgattttag tagctaccat gaaagaacca acaccatatg
    19861 catcaatgac aatacctaag ttatcttcgg atgcattaac ttcttttgca acggctaaag
    19921 ttgtatctac aaagtcacgt acttcgtttt cactaacatc aacgacttcg tatttacctt
    19981 ctttaaggta atctttgata acttctttaa gttcttgacc tgctttgtca gcaccgataa
    20041 taattgccat tttatttctc ctatgattta gaataagtaa atgtggaaaa cctacgtaga
    20101 tagttaatta acgatttgca acatcttttg aaataacgct ttcattattt ctatgaccta
    20161 atcatacacc caccaaacat aaaagtcaac atttttttgt ttatttttat aaaaaataaa
    20221 caaaatatgt ttattttttt catttttacg ttattgtcct aatgtttctt gtgtttcttt
    20281 ttcatttcat aaatcccttt gacagtcact cgtaacctat catatattac gagaccctta
    20341 tctctattta ttgtaaacgt tttatttaaa acattttcta ttttgttaat ttttgttttt
    20401 tccaatgttt atgtttgttt tgtttgattt ttttattgat attatgttat gataccttta
    20461 atagttatac cctaagacac tgataggaga taagaatgaa aaagaaagag cgtcatgaaa
    20521 aaattctcga tatcttaaaa gttgacggtt ttataaaagt aaaagatatt atcgatgaaa
    20581 tgaacatctc agatatgacc gctagacgag atctcgatac attggcagat aaaggattac
    20641 ttatcaggac ccatggtggt gctcaatatt tggattattc ttcagcaaag gacgaaggtc
    20701 acgagaaaac acacactgaa aagaaggtct tacagactac cgaaaaaaaa caaattgcac
    20761 aaagagctaa aaacattatt aaagatggcg aaactgtctt tataggtcca gggacaacat
    20821 tagagcatct agctgtcgaa ttgaaaaata gaaatatcag agttattaca aatagccttc
    20881 ctgttttttt aattttgcac ccgagcacta ctattgattt gattttaatt ggtggtgaat
    20941 gtcgtgaaat tactggtgct tttgttggtg ctattgccat taataaccta gaaacattaa
    21001 cattttcaaa agcttttgtc agcgcaaacg cagtttacaa taattctatt gcgacgtaca
    21061 gtgatctcga aggagaagtt caaagggttg cattgaataa tgctgttgag aaaatccttc
    21121 tagttgatag taccaagttt gaaagttatg acttctataa tttttaccaa ctagatcaag
    21181 tggacttaat tgtgactgat aaaaatgtga caactgatat catagaaaag tacaagaaat
    21241 tctcaaaaat cataatcgct gacaagtaaa ggacctactc atattaaaaa gcacttcagg
    21301 gtttagatat atcccctgtc aagtaaacag ggagcatatc tgaaagtagt gtttgtgtta
    21361 taaagaagtt tcttgctaac ttattttctg ttttttttca gacttatcag tcttgtactg
    21421 ttcctttttc tgatgaataa cgtggaaata ggcagacagc tatatatttc acctctagaa
    21481 tggttgccat tactgtcatc aagacatgct tgttctttat cgtatggagt aaagctttct
    21541 tttagccatc aacatacctc ttaagtagat tttggttcgt taccatgtct acttaagagg
    21601 tgtcttcaaa gcgctttaaa acgttgctat aacagtatat taacgttttg agaattgtga
    21661 agctttacga gcttttttaa gacctggttt ttggttgata ttctgatata cataaagata
    21721 cttataaaat caacctattc ctggttcaat caatcaaaat ctattaatta tatacaaata
    21781 tcttattccc aacggtatca ataaggtatc aaaaataagt ttcggagctt atcaaataat
    21841 gaaaatctgt ctcaattacc gagtcttttt tattgacttt tttgtatata tgatataatt
    21901 aaataagtta cataaagggg ttacataaaa tgactacagt aaaaaaaaac agagcggtta
    21961 cctttcaagc taataaagaa ttggtaagcg aagcaatgac agtattaaac aaaaaaaatt
    22021 taaccttatc atctgcttta agattattcc tacaaaatgt cgttgtcaca aacgaggttg
    22081 acttattgac ggaagaggag ttagagaaag aaaaactttt caagcaattt caagctgaaa
    22141 tcaacaaaaa tattgaggat gttcgtcaag ggaagtttta tacctctgaa gaagtgaggg
    22201 ctgaacttgg actataagaa atatcagatt atctatgctc ctgatgtttt agagaagcta
    22261 aaagaaattc gtgattatat ttctcaaaac tactcctcaa catcaggtca gcgtaaaatg
    22321 gagcaaatca ttagcgacat agaaaaactc gaggttttcc cagaagttgg ttttgatgcc
    22381 gatgaaaaat atggttcaaa aatcagtcat tatcacagca ctaaaggtta taccttaagt
    22441 aaagattata ttgtcctata ccatatcgag ggggaagaaa atagggtcgt tattgattac
    22501 ttgcttccta ctcaaagcga ctatataaag ttattcaaat aacacgttaa aagccttagc
    22561 agtcttgcta gggctttttt ggtagattac caattaacta ggagcaaaat gagttcgggc
    22621 tgtttagtag atattccaca aagaagccaa agactacgaa gctaggctaa tctaccttaa
    22681 ggcttcagga aacttggagg agttcaccaa gccaactcat aaaacttata gcgagatatt
    22741 cgagaaatgg tatcaagctt atcaagatac ggtagagcca accacggctt ctcgtactct
    22801 tgatctgttt cgacttcaca ttttgccagt catgg
//
