LOCUS       NZ_CP035434            23785 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Streptococcus pyogenes strain emm75.1 chromosome, complete genome.
ACCESSION   NZ_CP035434
VERSION     NZ_CP035434.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1887700)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Atlas of group A streptococcal vaccine candidates compiled using
            large scale comparative genomics
  JOURNAL   Nat. Genet. (2019) In press
REFERENCE   2  (bases 1 to 1887700)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2019) Department of Microbiology and Immunology,
            University of Melbourne, The Doherty Institute of Infection and
            Immunology, Melbourne, Victoria 3000, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005163865.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 01:48:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,868
            CDSs (total)                      :: 1,779
            Genes (coding)                    :: 1,714
            CDSs (with protein)               :: 1,714
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 36 of 65
            Pseudo Genes (incomplete)         :: 31 of 65
            Pseudo Genes (internal stop)      :: 25 of 65
            Pseudo Genes (multiple problems)  :: 24 of 65
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:28:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1290145
            Orig. end                         :: 1313930
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035434.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23785
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="4"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23785
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23785
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13785](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13785)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    154..168
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(1395..1895)
                     /locus_tag="ETT65_RS06635"
                     /old_locus_tag="ETT65_06635"
     CDS             complement(1395..1895)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="ETT65_RS06635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06635"
                     /product="QueT transporter family protein"
                     /protein_id="WP_020833390.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRVSEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMLTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     ISF"
     regulatory      complement(1893..2008)
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(2173..4905)
                     /locus_tag="ETT65_RS06640"
                     /old_locus_tag="ETT65_06640"
     CDS             complement(2173..4905)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="ETT65_RS06640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06640"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_136097834.1"
                     /transl_table=11
                     /translation="MINKKCIISVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSVAQVRKGPEERTCTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGTDVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     LKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     misc_feature    5107..5122
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    5228..5239
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    5456..5469
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     gene            complement(5476..6594)
                     /locus_tag="ETT65_RS06650"
                     /old_locus_tag="ETT65_06650"
     CDS             complement(5476..6594)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990425.1"
                     /locus_tag="ETT65_RS06650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06650"
                     /product="ABC transporter permease"
                     /protein_id="WP_109828703.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLITFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALISFSSLLLKPTKL"
     gene            complement(6591..7718)
                     /locus_tag="ETT65_RS06655"
                     /old_locus_tag="ETT65_06655"
     CDS             complement(6591..7718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="ETT65_RS06655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06655"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_002985266.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIRLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            complement(7727..8650)
                     /locus_tag="ETT65_RS06660"
                     /old_locus_tag="ETT65_06660"
     CDS             complement(7727..8650)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="ETT65_RS06660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06660"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            complement(8675..9358)
                     /locus_tag="ETT65_RS06665"
                     /old_locus_tag="ETT65_06665"
     CDS             complement(8675..9358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="ETT65_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06665"
                     /product="SagF family protein"
                     /protein_id="WP_136118033.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLVALSYQDFLDAL
                     LSLFQFVIIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            complement(9355..10026)
                     /locus_tag="ETT65_RS06670"
                     /old_locus_tag="ETT65_06670"
     CDS             complement(9355..10026)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="ETT65_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06670"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_136118032.1"
                     /sec_met_domain="Abi (E-value: 1.2e-08, bitscore: 32.0,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFIGLVFCVLIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            complement(10001..11359)
                     /locus_tag="ETT65_RS06675"
                     /old_locus_tag="ETT65_06675"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="ETT65_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06675"
                     /product="YcaO-like family protein"
                     /protein_id="WP_002990434.1"
                     /sec_met_domain="YcaO (E-value: 6.7e-63, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 4e-111, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            complement(11379..12437)
                     /locus_tag="ETT65_RS06680"
                     /old_locus_tag="ETT65_06680"
     CDS             complement(11379..12437)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="ETT65_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06680"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_136048178.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 2.9e-40,
                     bitscore: 133.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 1.6e-139, bitscore:
                     461.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQVLPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     aSDomain        complement(12168..12437)
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_ETT65_RS06680_Cytolysin_C_RRE.1"
                     /evalue="4.50E-42"
                     /identifier="RREFam014.1"
                     /label="ETT65_RS06680"
                     /locus_tag="ETT65_RS06680"
                     /protein_end="90"
                     /protein_start="0"
                     /score="133.3"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLYYNDMLML"
     gene            complement(12434..13402)
                     /gene="sagB"
                     /locus_tag="ETT65_RS06685"
                     /old_locus_tag="ETT65_06685"
     CDS             complement(12434..13402)
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="ETT65_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06685"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_136097833.1"
                     /sec_met_domain="PF00881 (E-value: 2.1e-32, bitscore:
                     109.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASIRDGASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSE
                     ENVRDFAEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATA
                     LTYGSIDIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     misc_feature    13600..13617
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(13624..13785)
                     /gene="sagA"
                     /locus_tag="ETT65_RS06690"
                     /old_locus_tag="ETT65_06690"
     CDS             complement(13624..13785)
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="ETT65_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06690"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 1.8e-29, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    14311..14324
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
     gene            <14348..14464
                     /locus_tag="ETT65_RS06695"
                     /old_locus_tag="ETT65_06695"
                     /pseudo=""
     CDS             <14348..14464
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611996.1"
                     /locus_tag="ETT65_RS06695"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06695"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLTLKTKEEVHWWNYHHLHSNLNYQTPITK"
     gene            complement(14650..21168)
                     /locus_tag="ETT65_RS06700"
                     /old_locus_tag="ETT65_06700"
     CDS             complement(14650..21168)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407459.1"
                     /locus_tag="ETT65_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06700"
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_136105780.1"
                     /transl_table=11
                     /translation="MFLKHQDVKQKNWRMRKVKKLFVSSCMLLTVGLGVAVPTAFSQSN
                     GVMVVKAAEVSEEVSKLPTVSFVKQNPEGSDTSKRVLWGPEVDKTYSKHAAGSDQRKYY
                     DNDVKAPVLRVGILGSSTNGGIEISAPVYSNTNYTLRVNLAHQMTWVRLGYKGAVKTGE
                     YYEKTKSNKLYTHEMRLVTSNKKHVYQGEGSEGKLTMYVYRDNRVDGKNNSAAIIKDAI
                     LVPDTPKLVPQNKELELKLSKVENKSIQSIVNEIPEVSKILDSLVTDSAHFNNPVKSTW
                     SKIDNPDKVITTVDDSFVLNYTAEKWGQNTSGKVTVRLIEDRDYKKDIDLAKQSLLDIK
                     KKTIKQIDLDNWLSDDEKRDQTSEVERTYTEGESEINKAKTLTTIHDVLKKYSTEGNNI
                     SIPDQYKKGKKEAKVSQEKEKLQSVYDTEKNKIVQDKWSSTSQKQEEQRLLDSVKTEAE
                     NNLSETNSLQDLLSKSPSEQDKLRKIYKGNKEQKVREDGLKNLKKTLLDTQIAIKEDNW
                     LSNGAKKMQLTAAQKAFEKGAKELQNSQDFATHEEKFNNYVSKDTEKHPDSIPNQYIPG
                     NQEEIKSKEKVNLKKVYDDTISNINQDNWLSDEDKQKQTAQATQAYENGIQDISSADSL
                     INLKQVVEKSVGNEDETSIPNKHIKGDQKKEVDSATQKLQEIHKKTQDAIETDPWLSPE
                     QKKAQKENAKARLDAGLKAVETTESLDKLKEVESDFLDKEKAESIPSQHQAGTPEVARK
                     TFLDNFEKEAKKEIESIDKDDTLTANAKQVAKDKVAQQLQEATAKVEKAQSFDDLKKVE
                     TEFVPALPHTKGEKLNQQQTEAISGLEGVQKATEKAISEDKTLSKDEKKKQIADSKERL
                     KSDTQKVKDAKNADAIKKAFEEGKVNIPQAHIPGDLNKDKEKLLAELKQKADDTEKAID
                     SDKTLTAKEKEEQKAKTKEELQKATEAVGAIDNREELDEKVPELKKAIEDTHVKGNLEG
                     VKNKAIEDLKKVHDETVAKINGDVTLDKATKEAQVKEADKALAAGKEAITKADDADKVS
                     TAVTEHTPKIKAAHKTGDLKKAQEEANTALDKAAEKEREEINNDITLTAKDKEQQLKEV
                     ETALTKAKDNVKAAKTADAINDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAKET
                     KDKISADPTLTSKEKEEQSKAVDAELKKAIEAVNAADTADKVDDALGKGVTDIKNQHKT
                     GDPVVARREAHGKQLDRVAQETKDAIEKDPTLTTEEKAKQVKDVDAAKERGMAKLNEAK
                     DADALDKAYGDGVTSIKNQHKSGDPVEARRGLHNKSIDEVAQATKDAITADTTLTEAEK
                     ETQRGNVDKEATKAKEELAKAKDADALDKAYGDGVTSIKNQHKSGKGLDVRKDEHKKAL
                     EAVAKRVTAEIEADPTLTPEVREQQKAEVQKELELATDKIAEAKDADEADKAYGDGVTA
                     IENAHVIGKGIEARKDLAKKDLAEAVAKTKALIIEDKTLTDDQRKEQLSGVDTEYAKGI
                     ENIDAAKDAAGVDKAYSDGVRDILAQYKEGQNLNDRRNAAKEFLLKEADKVTKLINDDP
                     TLTHDQKVDQINKVEQAKLDAIKSVNDAQTADAINDALGKGIENINNQYQHGDGVDVRK
                     ATAKGDLEKEAAKVKALIAKDPTLTQADKDKQTAAVDAAKNTAIAAVDKATTADGVNQE
                     LGKGITAINKAYRPGEAVKARKETAKADLEKEAAKVKALIAKDPTLTQADKDKQTAAVD
                     AAKNTAIAAVDKATTAEGINQELGKGITAINKAYRPGEGVKARKEAAKADLEKEAAKVK
                     ALITNDPTLTKADKAKQTEAVAKALKAAIAAVDKATTAEGINQELGKGITAINKAYRPG
                     EGVKARKEAAKADLEREAAKVREAIANDPTLTKADKAKQTEAVAKALKAAIAAVDKATT
                     AEGINQELGKGITAINKAYRPGEGVKARKEAAKANLEKVAKETKALISGDRYLSETEKA
                     VQKQAVEQALAKALGQVEAAKTVEAVKLAENLGTVAIRSAYVAGLAKDTDQATAALNEA
                     KQAAIEALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALKTAIATVRSAQSIASVKE
                     AKDKGITAIRAAYVPNKAVAKSSSANHLPKSGDANSIVLVGLGVMSLLLGMVLYSKKKE
                     SKD"
     gene            21640..23181
                     /locus_tag="ETT65_RS06705"
                     /old_locus_tag="ETT65_06705"
     CDS             21640..23181
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /locus_tag="ETT65_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT65_06705"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_136075691.1"
                     /transl_table=11
                     /translation="MLHLHLETKLQDKLSLLNILLDVSEVSIDQLCQETELKKQRVYNL
                     LIEMIKDLEDTLTLTICDDTVSIPYKTYQLKMPYFKKLYQTSIFLKMLCFLIEPGELSL
                     HDFIKREYISQATAYRIRTNCRKYLKKVGLNVRQNHVVGPEYRIRFLIALLHYQFGMTI
                     YDFDKTSMNKVVSLIINSNQAITLNDASKAPYEFSYFAILISLIWKRRHDNLGIPQTDA
                     FKHLKKLSIYHDIKMTSQEIIGKWYHPDLTDEDLDYIFLCFCTTNNAFHKDKWTPKKVK
                     ELFELVMTKTNGKTLKASLRPLLGDNILNSLPFKRILVSFSRLFISNLQVLLPDIHLFH
                     YLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYHLLLFTIQLEELLKTYLPPIPVY
                     LLTNNTAALDLMTNALSIYFPPAIATVMPVNVEIIPFKDIVKEKQSVIIADRQYLNLIQ
                     HLYQNQGHLFLYFLFSFRDVSEAYIHKAFLDFRQKRYDEFIVTLLDTYHKNLSSP"
     misc_feature    23259..23270
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
ORIGIN
        1 cactaccaca agatgggcat agtttaggaa taagcatgac ttcttgctgg ttccgcttac
       61 tcataacgac atttaagaca gcaggaataa tgtcccctgc cttatataca atcactgtat
      121 cgccaatacg gatgtctttt tcggcaatat aatccacatt atgtagggtt gcacgactca
      181 cggttgtccc cgctagttgc acaggagtta gattcgctgt aggtgtgacc acgcctgttc
      241 gtcccactgt ccagtcaacc gaaaggattt ctgcctcttt ttcttctgct ggaaatttgt
      301 aagcaatggc ccagcgtgga gctttaaccg taaaccctag ctcttcttgc atggctaggc
      361 tattaacttt aataacaacg ccatctatgt cataagctaa ttgatctctt tttgcctcaa
      421 tagttttgat aaaatcccaa atctcatcca tagacgatgt gagttgataa tacggattta
      481 ctgaaaaacc tagatctgct aattctgcta agacctcatt ttgttgattt ctagctgtcg
      541 gactagcttc ttgatacaaa aaagtggcta gttgacgctt agcaaccact gccgtatcta
      601 gctgccttag tgtcccagcg gcagcatttc taggattagc aaattcagtc tccccatttt
      661 cttggcgtgc ttcattgatc gctttaaagg actgacgaga catgtaagcc tctcctcgaa
      721 cggtgatggt taaaggctca ctcaattggt gaggaatatc ctttattttt ttgatatttt
      781 ctgtgatatt ttcaccgata ttgccatcac cccgtgttgc tccaacctgt aagaagccat
      841 tctcataact caaggaaata gataaaccat caatttttaa ctctgctaga taggtggcat
      901 tcggaaattc ggccttgacg cgcttatcaa aagcatccag ctcctcacgt gaaaaagcat
      961 cctgcaaact aaaaagcgga tactgatgtc gatatttttc aaaccccttt aaaatagtcc
     1021 ctccaacctg ctgcgttggg ctatcttgca agacatactc gggatatgac tgctctaaag
     1081 tcaccagttc acgataaagc ttatcatagt cactgtcaga aactgatggg gcatctttag
     1141 tataatagtc ataacggtaa cggttaagaa gatctgttaa ttcttttatg cgttttttca
     1201 tacttttatt ttatcataaa agataacaaa tgagctattt ctatatcata acaacatcaa
     1261 aagtaatcgt tggccactcc atatggtact attagctaaa gtgttaaata tttctatcta
     1321 gaacgatttt aacattacaa acaacataaa aaagagaagg gtattgaccc aactcttttg
     1381 agtatgatgc attactaaaa ggaaattctt tgagacaact tatcaataat aagtgatcct
     1441 atgagcagag atactaattc tcctaacgca gttgtaaacc atgttaataa aaatggagct
     1501 ccaaagaagt aaagttcgat tgctacagta agcatggaag ttgcaaaaaa gaaagaaaag
     1561 taaacaaaag ctttattaaa aatgccatta aaaagataat ctttttgata cttactaaac
     1621 aaaataacac ctaaggtcac aaaaataaga gttgaaccgc cgcctacaaa gacatcaatc
     1681 agtccgaaac tataaaagtt agcaatcata catccaagag tcaccgcaat aatatacttg
     1741 cgatgataaa aagctaagaa attcatcatt tcagatactc taaattgata catcccataa
     1801 gaaatcgcat ttaaaggtgg ggtaatagtt aagacaacat acaaggcagc tactagccca
     1861 atgtgaacat agtcgtgtac agtcaatttt gtcatttttt ctcctttaac gtctggataa
     1921 ctctcaaaag ctatctacgt ttctaatatg cttggtgaaa gggaactaag caccaagggt
     1981 tgcaaagcaa cggttacatt gtaccataaa acaattagct tgacaaaagt ctttagcaag
     2041 taaagctgtc ttattgttat cttcttttgt gatcaatctt agtttttata tagtcatcca
     2101 ttttagctta aggtctaacg taagtatatc aagcctttaa cgactcttta tgaactccaa
     2161 ttcttcaaat cgctatgatt cctttttgcc tttagtcaat aataaaatag gcactaataa
     2221 actagccgtt cctagtagcg ttatcacata aacaagacta tctcctgttt ttggtaacag
     2281 ttttcctttt aaagtttttt tagcttttac actttgttta gaagactctg ccttatcatt
     2341 ttctttagaa aatgataatt gaagtaacaa tggatcatga tctgatgcgc gtccgtgagc
     2401 ttccataaat ggggaattca catgaaccat gtcaaattcg tagtgatcaa gtaaatggcg
     2461 tgaaactaat atattatcaa gggtctgatt attgccttgg tgaaaataag aataccgatc
     2521 tgaaatatca tgtcggctca ccaagttaac catatcacct tcttcgatta attgaatcgt
     2581 ctttgtgaat tcaaaatcat taaagtcacc tagcatcaca atattagctt ggtgttttgc
     2641 cccttctttc gcaaattgtg ctagcatatt agccaagacg tgacgtcttt gctcagattt
     2701 aaaagtgact ggttgcacac gaccataaag agcattatcc ccacgcttag agttcaaatg
     2761 atttgcaaca acaacgactt tacgaccttg gaagataaat tctgctgcta gtgatttacg
     2821 aacatctttc caagcggcgt tagttggatc aattcgacca acactaaggt ttaattctcc
     2881 attaacccaa gttagagcat cacgagcacc gccttttggc ttatcagaaa ggctgacgcg
     2941 ctctggttga taaaggaatc ctgttcgaat attaccacct ggttgacctc cgtcaacatt
     3001 attttctgga gcaatatcaa cataacgata agttgggcca cctagttttt taatagcatc
     3061 aatgaggcgt tgtgcgcttt gtgtcgcatc cgttgtccca tcatcagtcg gcccattatt
     3121 atcttggact tcaattaatc caataatgtc tggagcattc agatcatgaa taaaggattc
     3181 ggcaatccgt ttgaccttct catctttagt tgaagaagga ttggctgaga agttttcaat
     3241 attgtaagaa gcaatgctta acttgctaag gtctttttgc aagtttgttt tttcaggttt
     3301 tagatgacca tccattaaac ttggcatgtt tttgctgtca tcaacaaaga ccttgtaatt
     3361 accatagcta taagatactg gcccagctaa tcttcctttg taagagtctc ctgctttaat
     3421 aatttgtttg ccttttttga aaagaacagg aatcacatct gtgttataag aattagctgg
     3481 aagtaatact ccacctgaat tatttaacgg tcttgtacta gagccaggta agacataaat
     3541 ttctttattt ttcattggac caaggatttt agcatcatca accgccacta acatgccttc
     3601 cattgattcc caataatcaa tagcgtcttc ttctggatca aacacacgca agccatcatt
     3661 atcaataata ttggctggcg cgatacgatc tttccctaaa acaagcggtg atggaacttg
     3721 agctgtccct gttttggtca ctgctttagc cacaatttgg gtgatggtaa ggtcagtctg
     3781 cttacgttcc tcataaccac gaccaaagaa ttcttccact tcacctgaaa tggtcaaaac
     3841 atcgccgact tgaaccttag cgtttttagc aaaaacacga ataccatctg aagtcgctaa
     3901 atcaccatca ccattaagat cttgaacata aaaatgagtg gaatcgtcta aataagtgac
     3961 aacaacctgt tctacggtga ccgctttttt gagaagtggc gacgtatgac tagctccttg
     4021 aatctcgcct attttcacaa tattacgaga tgaagcatca ctatttgagc ttgtgacctt
     4081 tttaaccact tccaattgtt caagagaaaa cggtcttaat tgtaactgac catcaacaat
     4141 agacaatatg gctgtgaggt taatcaaatc accctgactt attttagtaa caacatcagt
     4201 ccctttaacc cctgtacgat gatctatatg aacaactata cttttaccac tatcatccct
     4261 tacaaggaaa gatgtgttgt tatattgatc agttgataat tctccaactg tcacgtgaga
     4321 taacttaact aatgttgagg gtgttgttgt ttctaattct gatattactg cttctttaac
     4381 agaagtcgga aaagataact ctaacttttt gtgtgcagtc acctgttgga gttgtaaatc
     4441 acctttaaag cgagtaagtg tacctgttaa ttgaacaata tctcccttac tgtatcctaa
     4501 atctttttga ggataaacat aaagtccaat accttcacta tcttgaatat aaaagccata
     4561 gcctccccag ccattgatca cactcgtaat cttgccagta acagtacagg ttctttcttc
     4621 aggccccttt cttacttgag caacagactg ttcagtagtt acttttactc ctttatcagg
     4681 tgttggcaaa ggtgtttttc tctcaccaaa atccacactt gctaggtaag gtgatatgac
     4741 gggaaaattc gatttatcac taataacaga ttctctcttt ggcctttgtg ttacgatttc
     4801 attggcataa gtcaaatttt ggcgtgaagt aacttcttca acactagtaa gcgtaatagc
     4861 tagtgtcaac aatgaaacag atattataca tttcttgtta atcatgatat ctccttttaa
     4921 tgtgattagt ttaagacaac aacaagattt tatttttgaa tattaacctc cacctgagac
     4981 tatgaattgg gatacacttt ctgtttgcat taattatact atcaagtaac acgattagat
     5041 cttttctttt aatctgttaa gtcacccaat taaagacttg tttgatctga cataacatca
     5101 caagcacccc tgatagcgaa caagacagct ttatagcatt cgatacatgc ttattgtaac
     5161 aaaaacattt cataaaataa atacgttttc aaaacttttt ttaataacat tagtttctat
     5221 gtttattgaa aacgtttttt aaaatacttt gacaacccat ttatcaacaa aaacgaactt
     5281 tatagagagg tcgcttttga taatatgctc tctaaaaaac acagtaacaa cagtaacatc
     5341 gcaatcgctt ttaacaaaag ataagtgcac tagagaaaat ataagcaaaa agcaaccctt
     5401 ttattgcata taagccaata aaagggctac ctggtagtta gctaattagg aaagtatttt
     5461 ttaacaaaag actaattata gtttggtagg ttttaataat aaacttgaaa aactaatcaa
     5521 agctagtgct gttcccatta gagctaacaa gtatggccaa gcctgagata aggtccctcc
     5581 actttgaaaa atagctatgg ctgataaaac ccaattttgt ggtaataact taccaattgc
     5641 ttgcatataa gaaggcgtaa tagacaatgg ccataaacag ccagccaaca ttgaagtcgg
     5701 cattacaata agattagcta actggctact ttgttgggaa ttttgtgtga tagctccaat
     5761 cagcaggcca aagcctatcg ctaataaact aaaaaggaaa aaagtaatca aaagaagtga
     5821 tgtcggaaca aaaaaactaa tattaaatac ttttaacaaa ctcagcataa tgacaatttg
     5881 aatcgtaaaa gcaacaaatc ctacacagac gtaactcaac atatagcgaa aacgagataa
     5941 gttcgataac attaatcgat ggtataactg actagattta tctgccaaaa taccactgta
     6001 aatcacgctc gtactaccta acattagaat aagcaaaaat cctgtcgttg tggaagatac
     6061 tgctttgcta cgtgatcggt ctgtcaaagt tacttgctta acatcatagt ttaactgttg
     6121 gtttttttgg agaattctat taaaagtatc ttcgttacct agagccacat cccctataat
     6181 attatagttt tccaatagat aattggtctg tgcctttacc cactctgtaa tttcgctatt
     6241 agcaatcgaa cgtatattga gtttttgaga ttttccttgc aacactttat ctgagaaccc
     6301 tttatcaata gtcaataccg cttctagaga tttatcttga aggtagtgat caatatgctc
     6361 ttttttgatt ttggtaaaaa tgtcgtactt tttgttttgc tttagttgag caataaattg
     6421 tttagatatc tgactattat ctttatctaa tatcccaatt ttagcctgat tattatttga
     6481 aaaactcaaa gataaagcca aaagtgtcgt taaaataggc attaaaaaga atgtcacata
     6541 acttgttttt ttgcgcttta tcttaacaaa tagagttttt ataaaacaaa tcatgtcgtc
     6601 acctgctttc tcatacctat taatgccaat attataaaaa ttgttccgat actaatatta
     6661 acgatcaaag ttacaggaat cggattatat tgaccaccaa aaataagata gaacaaacta
     6721 tcattaaccc atttaatagg agatatattc gacaattgat taataataga gctgtgtaat
     6781 gttgtcaacg gaacgtaact gcctcctaaa aaggcgaata taggaataat agtattggat
     6841 gcaaccgtta aaaaagcctc atttttaatg cttatgccta gcccgatacc tatagctaca
     6901 gagagataga ctaaggaggc tgttatacca ataagcatcc actcattagt gccccaatta
     6961 actcgtaaaa caaaccttgt aaaaatgtat aaaagactca attgaacagt tgttgctaac
     7021 atagcaccta ttaatttccc aaagactaaa agacttggag aaactcctgt taagcgaata
     7081 cgatttgtaa tccgttgttg acgatctgac aaaacaaggt tcatcgcaga catcatacta
     7141 taaaaagtaa tcatggtaaa catggaaata gcataataat cagctgatgt cattccttta
     7201 cttgtctgta ttgaactgac cttaacatag tccacacttc gctttctgat atgatttaat
     7261 tgttgaggat aaagagctgc tatcgagtca taagttttag cattatctac ataatttttt
     7321 actagcatat tgattaaatc tgcattttgc tgattaatat tattagtaat aaccttaatg
     7381 gtctgattct tcttcacttc taaaacagcc gttaaggctc cttcactgac cctttgtcga
     7441 tctttttcaa gagaattact aggtttagcc tctaaatgaa gtttttggtt taaaactttt
     7501 aaaaaagcaa gaaaattttt ctggtaatcc gttttttcac cctctaattg gtaacgaatg
     7561 gtcaatttag ggactgttgt cgcagtatta aaacttgatt taaaggcaaa acttaaaata
     7621 acgatcatca aaattggaaa aatcaccatc atcaataagg ctgttcggtt tctaaaaatc
     7681 tgtaaacttt cttttttgat taaatgaaat aaaaccatag taacctctaa tctcgtaact
     7741 tcttacctgt taagtgtaag aaaatttctt ctaaattcaa atggttatgt ctaatctcgc
     7801 taaaagtaat attggcctgt gtgagctgat gaacaactga tgtcatatca ctattatcaa
     7861 tcttcaacat gagtttttct ccatcttcta tcaaagacca atcaggctta tctgccagtt
     7921 ccaaatgacg tgaatctgtt agagttacaa taatctggtt tgctagattt gcaacgtaac
     7981 gtttttccag ttcaaattta ggtccttctt caataacttg accatgatcc ataataaaaa
     8041 tataatcaca aagagcctct acttcttcca tgtaatgggt cgtataaata actgtagcac
     8101 cttctttgtt tagcaaacga atcgactcta aaatatgatt acgtgattga ggatcaatcc
     8161 ctacagtcgg ttcgtcaaaa atgattaatt taggtgaatg aactagcgca caagcgatat
     8221 ttaaccgtct cttcattcct cctgagaatt gacttggaaa ctgcttagct tgggagtgta
     8281 gccccacaaa ttctaaactt tttagaactt gttttttaag ctgagctccc tttaagccat
     8341 aaagtgaccc aaatagttct acattttcat aagcagttag gtctggataa acagcaatgt
     8401 cttgaggaac ataacctatc tgcgaactta tttttcgaat agtcttttgg gattgcccta
     8461 aaacagtaat tttaccggaa ctcaaaggga tcaagcctaa gataagatta atcaaggtag
     8521 acttaccagc accatttggt cctaacaaac cataaatatt acctgcttca atagacaagg
     8581 aaacatcatt gacagctttc ttaccgtttt tgtaggactt gacaacattt gttaattgta
     8641 caaaactcat atatcactcc tttttttaat attgctaata ctctttgcaa ctaatcatca
     8701 aataagtcac tgttaatatc atcgcaccta ctagccaacc atataataaa gttgccgtaa
     8761 ctgcccatag tccaactata gtgaaaagac aaaaagctaa tagtacattt aaccaacctg
     8821 aatagcgaca agccttgact atcccataac ctaaaataag cgttgctaaa cttgttagcg
     8881 actgttctcc taataatata agcaagccca aataaaagag actgtctact agaataacta
     8941 tgcctagtaa aagtatactt aagactggtt tatcttgtct aaaaggcagc caagttattt
     9001 ttttaaagag caatcgactg tctttctgga gcaaaacatc aaagataaga attaaaacta
     9061 aaagcgtcat ctctatgatg gccataagat ataacactaa ataacaaaga atctgccaat
     9121 gccagctagt ttgtgtcaaa aaggtcagaa cctctcctag attaatagta gctgagtaaa
     9181 agaataaaac aagtataata atgacaaatt gaaacagact cagtaaggca tctaaaaaat
     9241 cttgatagga taaggccact aaccattgaa gatgccatct agccaaacaa cgtcttcgat
     9301 aactggtcaa ccaaagagta gttaaaccta aaaacgacag caaaaccaat agcatcatgt
     9361 cacctccttc ttcttttttg tttgaagatg gctaagacac tcaactagca agttccctcc
     9421 tacatgcatt atcacaacca accacaattg actagtcagc atgtaaatac taccataaat
     9481 gatgcctgtt accaacttag cataaaaaat ggatttcccc atcaataagt gatttaaagc
     9541 atagcaaaaa ctagttacaa ttaaaacaat aattgttggt aaatgccatt gaaaagctaa
     9601 tatattaaac cacaaaaaac gataaatcgt ctcttcaaat aaagctagta ataaaggata
     9661 gccaatctta gaccaatcat ttgtcgttcc tacaaacgag aaagttgcag gaagccattg
     9721 ctttttttgc caacaacgta aaccatgtaa gaaaacgagt tcaatcagta ctatcaagac
     9781 gcaaaataca agtcctataa agaacgtctt actatcaata ctttcaagag acaaggttat
     9841 ttgaggtgac aaaacataaa tacttaccaa agccaaaatg tcataaatca gagttgctct
     9901 tagaaaacca attaaattaa atgcataacc actatcttct ttcccaaaaa tagcttgcat
     9961 aggaattgaa ggacaaaaag ttaccaacaa aaaacaaaga ttaaggcatt ggatggacaa
    10021 aggcatttgt tacacctcca aactgtctca ttcgtggatg attagcaaaa ggaaatgctg
    10081 gtatacacat ttcaagaagt tctggcatca gaactcgcgt gacgtaccag cctttttcta
    10141 gagcttcagg aggtgtaata tctaaaaaga cagcattagg actgactttc ttagcataag
    10201 ctaataaagt cttcaaatct tcttttttat ctttaccaga atgatcttcc aaatcactta
    10261 acagaacttc tcctgaaatc aaaggttcaa aggccttcca tttatggtct tggtccttgg
    10321 gatgtgcata atagaaaaca ttactatcta aatctaaaaa caaaggttct tcgcattcaa
    10381 tatttgcaag ggaagctttt tgatataaaa gattatagta gtaactatag ctgatagctg
    10441 aagcttccat gatccctctt agcaaagcat gtttaggatc taacccagcc tgcactccaa
    10501 acaagaggta aggcccttca tcatatttat ttttgagaat gattccaaac gtataaagag
    10561 gattatcttc tcctacagtc atatcgatag gaataatgtc gtatagactg tcttttccca
    10621 gtctagcttc ttctaaaatc acttcaatat caggatcatc aacaataatc ttggggcaag
    10681 gcttcttagt ataccagcta agcatcattg aatcgatctg gatgtattca atcaaactgt
    10741 tgcacatagc cgcttctaac gttttgtgag aagctgttcc cgtagaaaat cctggtatta
    10801 tccgtctttc tcctacagtc tcatttgttt tatacccaac acaaagcatt tgagctggaa
    10861 catacatctc tgcgtcctca aagaacatgg gacatttaac ccagcccaat acatcgttct
    10921 cagttaccat tttatcgcac atcatcattt gcaagtcaca agataatgcg atctgttctt
    10981 gagtaaacac ttgcaagtat tctaaaggca tcactttatg taacagtttt aactcattat
    11041 aagaagcata gacaatccga tctgatagta agtctccggc aattacagta gcatagcgtt
    11101 caatactttc tcctaaatac ttgataagtg cttcttcata gtaactgccg taaccaataa
    11161 tgtgataact aacttgactc aactcaccta taaattgttt atgataatct ggcatttggc
    11221 cagtaatact ttttaagtaa acatcgtgag gatggttgca aactggaact tgagattgat
    11281 ttaagatacc tgttcgattg ccacttaaac tttttaattc atcaaaaata tgattaaaag
    11341 aaggataata gtataacata atagattctc cttataggtt actcgtcaag gagtttttta
    11401 acaatctcac gtgttgatat ctgctgatcc tcatatttta attttgccaa agctccttgt
    11461 gtctgtgaat tagacatttt caaaatgtct tggacctgaa tctcaagcgt cggtaagtaa
    11521 atgcttaata aacgtccctc aaatttagaa ctacctgttt gagcaataat gaaagcttcg
    11581 ctaacgacta aattcattaa aacatttaac aatggtaaat aggcctggct cacatcttgt
    11641 gttgctggta aaacctgatt agcaaaatgt tgatagagag ttgagtcttg taaacgtgcc
    11701 aaaactcttc tttctaagct atcaaagtca gcactatggg gaggattcaa agtacaagtg
    11761 tgcaagaatg gtccatctac aaaaccaatc actaattgtt ttttcatagc tacgctaact
    11821 tcattcaagt gtcgcaacat cataatattc aagcgttctt gacaaataat aatactttgg
    11881 taatcgcaca aggcttctga taaacaattc atgttacggc gatgctccaa agcatctaaa
    11941 cgcgaactaa catctgtctg ctgaattaac atttttaagt catcgctagc cacttgcaat
    12001 tgtaaatgca gttgttcagc tagcaactca gcagattcat taacataagt cgaatcactg
    12061 ataaacaaaa caggatcatt gcttaccata tgacctgctt gcgccataaa acggaaatta
    12121 cccattaaaa ttttcatgac attttcttca agattgtagt catcctcaag catcagcata
    12181 tcattgtaat acaagcctga aatgacttcc attaaattag cgaacgtctc aggttctaaa
    12241 gcattttcat aagtttcagt atcaatggct actcccttaa ccaactgtga aactatttct
    12301 tgataaacta tctttaaatt ttgaggttct tgtgtcaaat ctagaatggc ttcattaaag
    12361 tcccagattc cttttctaaa acaaaatgta tcttgaaatg tcacgacacg aacattacta
    12421 ttaagttgat atttcattga gactccttag ttcctacgag tgtcatgtga atcacatgct
    12481 ctcctagccc atctaaatct aataattctt ggagatattc cttattataa ccaccaatat
    12541 caatacttcc ataagttaag gcagttgcag tcaattgaat attctgggct atttctcctg
    12601 attcaataaa agcataggca gtcgcctgat tcccatattt acgtgtattt ttcatgtaat
    12661 ggtagacata aataataata atattacaat tttcagcatt aatagcaccg tattccgcaa
    12721 aatctctaac gttttcctca gagctatgcc gataacacct tagtgcatgc tgatagggta
    12781 gatattcata gaaaccatct attaatttac tgatgtttct agcataaaaa actaaatgaa
    12841 tagggtataa acctccacct gaagcacagt ttctgagtgt aatcttatct gatgctccat
    12901 ctctaattga tgctccatct ctaattgatg cttgtgaact aacaccacat gcataataaa
    12961 gaatgtttga taaatcttga agaggcattt gtctatctga aaattgacga tgacttcttc
    13021 gttttataat acatgtcgac agagcagttg atatcttggt aggttttggt aaacgaatta
    13081 tcttttcctg actttcataa acgtaactac ttgaaaaatt agcaacggca gaatctgtaa
    13141 aaaagtcgac aatactagct tggaagccta aataattatt attagcttta tagttcatca
    13201 aaaaatgttg actaagatta tcggttgcat taggcattaa atgttgagca actagctgct
    13261 ttgacgtttt tagcaccgtt tgatgatggt aatccgataa ggacaagtgg tttgtattaa
    13321 attcaaacaa ttgccttgct ttttcaacag ttattggcgg acaattctct ttaggttgtt
    13381 gttcctttgt aaaaaatgac ataactatct ttcctatctc attttactaa acatatagta
    13441 attagcaggt actgtctagt acctgctaat tacctgagac gttagcatca agaagattac
    13501 ttttgtctca tgttttctaa cacctctatg ccattcatct ataatcagaa gttaccaaag
    13561 ataacttagt tgctagcaaa ctcattacct taatatcact atcacataga gatgctaaat
    13621 agattattta cctggcgtat aacttccgct accaccttga gaattaccac ttccagtagc
    13681 aattgagaag caacaagtag tacagcagca acagcagcct ccaggagcaa cttgagttgt
    13741 ttcagctaca ctagtagcta aaatatttga agtaaatttt aacataaggt ttacctcctt
    13801 atctaataag taactgataa gaacacgagt cgtttatttt taaccttatt ttaaaaataa
    13861 agttaacaca acaaggacaa ggctagctca attgtactgt tgtaacacaa caactatcta
    13921 gttcttatca cttttattat agtaaaaaat gattaatatg taaacccttt ctttttaata
    13981 ttatcaaaaa tgacaaaaaa aataataatt gattaatata gaaacaatta tgatctaata
    14041 tactgaattt tataatagat tctatcgata actatgtgta aacaatcaag tagaaatgtc
    14101 tttattaagc gaatcaatca aggttgtaga gtaaatgctg gactagattt catgtagaaa
    14161 ttagtaaaag ttaggagatt ttttggtcgt ttcaaacgat aacatcatct tcttataaca
    14221 agaacttcac tcagagataa actattctaa tactttagta gcctcttttg agcttgtagc
    14281 acgaaaattc gctcgaactg atttaaaata ggcattttat ctgctcgctt gatccctact
    14341 gcgcaaccaa gaaacctttt attcactaga acaattaacc cttaaaacca aggaggaagt
    14401 ccactggtgg aactaccatc accttcacag taatcttaat tatcaaacac ctataactaa
    14461 atgagtcatc gtttgaacaa aaaacgcctt ataaattctg tacagaaaac tgttgccttt
    14521 tcaattgaac tttgaaatgt tttcaataca ctccgttctt gagcccttac gatccaaaaa
    14581 accaaggtga tttcaaaatc accttggttt gaaaatatag tagaaagcaa tttggataaa
    14641 gccaggttct tagtctttac tttctttttt cttgctataa agcaccatac ctaaaagaag
    14701 agacataact cctaagccaa caagaacaat tgagtttgca tcacctgatt ttggaagatg
    14761 gttcgctgac gatgattttg cgactgcctt attaggcaca taggctgcac ggatagcagt
    14821 aataccttta tcttttgctt ctttcacaga cgcaatagat tgtgctgaac gaacagtcgc
    14881 aatagccgtc ttaagcgcta atgatacatt ttctgattgt tcagcttttt gagcttcagt
    14941 caatttagca tcagttgtaa tcttagcaag tgtttctgcc gcagcttgtt taagagcttc
    15001 aatagcagct tgtttcgctt cgttaagagc agctgttgct tgatcagtat ctttagctaa
    15061 accagcaaca tatgctgaac ggatagctac agtaccaagg ttttctgcca acttaacagc
    15121 ttcaactgtc ttagcagcct caacttgacc aagtgctttc gcaagagctt gctcaacagc
    15181 ttgtttttga actgcttttt cagtttcgct caagtaacgg tctcctgaaa taagagcttt
    15241 agtttcttta gctacttttt caagattagc tttagcggct tctttacgtg ctttaacacc
    15301 ttcacctgga cggtaagctt tgttgatagc tgtgatgcct ttaccaagtt cttggttaat
    15361 gccttcagct gttgtcgctt tatcaaccgc tgcgatagca gctttaagag ctttagcaac
    15421 agcttctgtt tgtttagctt tatcagcttt tgttaaggtt gggtcgttag cgatagcttc
    15481 acgaacctta gcagcttctc tttcaagatc agccttagcg gcttctttac gtgctttaac
    15541 accttcacct ggacggtaag ctttgttgat agctgtgatg cctttaccaa gttcttggtt
    15601 aatgccttca gctgttgtcg ctttatcaac cgctgcgata gcagctttaa gagctttagc
    15661 aacagcttct gtttgtttag ctttatcagc ttttgttaag gttgggtcgt tagtaataag
    15721 agctttcact ttagcagctt ctttttcaag atcagcttta gcggcttctt tacgtgcttt
    15781 aacaccttca cctggacggt aagctttatt gatagctgtg atgcctttac caagttcttg
    15841 gttaatgcct tcagctgttg tcgctttatc aaccgctgca attgctgtat tcttagctgc
    15901 gtcaaccgct gctgtttgtt tgtctttatc agcttgagtt aaggtcggat ccttagcaat
    15961 aagagctttc actttagcag cttctttttc aagatcagct ttagcggttt ctttacgtgc
    16021 tttaacagct tcacctggac ggtaagcttt gttgatagct gtgatgcctt taccaagttc
    16081 ttggttaaca ccatctgctg ttgtcgcttt atcaaccgct gcaattgctg tgttcttagc
    16141 tgcgtcaacc gctgctgttt gtttgtcttt atcagcttga gtcaaggttg gatccttagc
    16201 aataagagct ttcactttag cagcttcttt ttcaagatcg cctttggcag tcgctttacg
    16261 aacatcaacg ccatcgccat gttggtattg gttgttgatg ttttcaatac ccttaccaag
    16321 agcatcattg atagcatcag ctgtttgagc atcattaaca gacttgattg cgtctaactt
    16381 agcttgttca actttgttga tttgatcaac tttttggtca tgagtcaagg ttggatcatc
    16441 attgattagt ttcgtcactt tgtctgcttc tttaagaaga aattctttgg cagcgttacg
    16501 acgatcatta aggttttgac cttctttgta ctgtgccagg atgtcacgaa caccgtcact
    16561 atatgcttta tcaacacctg cagcatcctt agctgcatca atattctcga tacctttagc
    16621 atactctgta tcaacacctg ataactgttc tttacgttga tcatcagtaa gcgttttgtc
    16681 ttcaataatg agagcttttg tcttagcaac agcttcagca aggtctttct tagcaaggtc
    16741 tttacgagct tcgatacctt taccaataac gtgggcattt tcgatcgctg tgacaccgtc
    16801 accgtaagct ttgtctgctt catctgcatc tttagcttca gcaatcttat cagtcgcaag
    16861 ttcaagctct ttttgaacct ctgctttttg ttgttctctc acttctggtg ttaaggttgg
    16921 atcagcctca atttcagcag tgacacgttt agcaacagct tcaagagctt tcttgtgctc
    16981 atctttacga acgtcaagac ctttacctga cttgtgttgg ttcttgatgc tggtcacacc
    17041 gtcaccgtac gctttgtcta aagcatcagc atctttagcc ttagcaagtt cttctttagc
    17101 tttagttgct tctttatcaa cattgccacg ttgtgtttct ttttcagctt cagtcaaagt
    17161 cgtatctgct gtgatagcgt ccttagttgc ttgcgccact tcgtcgattg acttgttgtg
    17221 taatccacga cgagcttcga cagggtcacc tgacttgtgt tggttcttga tgctggtcac
    17281 accgtcaccg tacgctttgt ctaaagcatc agcatcttta gcttcattaa gcttagccat
    17341 gcctctttct ttagcggcat ctacgtcttt aacttgttta gctttttctt cagtcgtcaa
    17401 agtagggtct ttttcaatcg catctttagt ttcttgagcg actctatcaa gttgcttacc
    17461 atgagcctca cgacgagcta cgacagggtc acctgtctta tgttggttct tgatgtctgt
    17521 gacaccttta ccaagagcat cgtcaacctt gtcagctgtg tcagctgcgt taacagcttc
    17581 tatcgctttc ttaagttcag cgtcaacagc tttagattgc tcttcttttt ctttgcttgt
    17641 caaagttgga tcagctgaaa tcttgtcttt cgtttcttta gctgcttctt caagtttagc
    17701 gacttgacct gacttacgag cacctaagtc ttgacctgct ttatggacgg catcaattgt
    17761 tgctacgcct ttatcacgtg cgtcattgat agcgtctgct gtcttagcag ctttcacgtt
    17821 atctttagct ttagtaagag ctgtctcaac ttctttcagt tgttgttctt tgtcttttgc
    17881 cgttaatgtg atatcattat tgatttcttc acgttctttt tcagctgctt tgtcaagagc
    17941 tgtgttagcc tcttcttgag cttttttaag atcaccagtt ttatgtgctg ctttaatttt
    18001 tggtgtgtgc tctgtaacag ctgtacttac tttatcagca tcatctgctt tagtgatagc
    18061 ttctttacct gctgccaaag ctttgtcagc ttctttcact tgagcttctt tagtagcttt
    18121 gtcaagggta acatcaccat ttatcttagc aactgtttcg tcatgaactt ttttaagatc
    18181 ttcaatagcc ttattcttaa caccttcaag attaccttta acgtgagtgt cttcaatagc
    18241 tttcttaagt tctgggactt tttcatctag ttcttcacga ttgtcaattg ctccaacagc
    18301 ttctgttgct ttttgaagtt cttcttttgt tttcgctttt tgctcttctt tttctttcgc
    18361 tgtcaaagtt ttatcggaat caatcgcttt ttcagtatca tctgcttttt gcttcaactc
    18421 tgcaagaagt ttttctttat ccttgttcaa atcacctggg atatgtgctt gaggaatatt
    18481 cactttccct tcttcaaatg cttttttaat agcatcagca tttttagcat ctttaacttt
    18541 ttgcgtgtca gatttcaaac gttccttaga gtcagcaatt tgtttctttt tttcatcttt
    18601 tgacagtgtc ttatcttctg agatagcttt ttctgttgcc ttttgaactc cttctaaacc
    18661 agaaatagct tcagtttgtt gttgattaag tttttcccct tttgtatgcg gtaaagcagg
    18721 tacaaattca gtctcaactt tcttcaaatc atcaaacgac tgtgctttct ctactttagc
    18781 tgtagcttct tgtagctgtt gtgccacttt atctttagct acttgtttag catttgccgt
    18841 taaggtatca tctttatcaa tagattcaat ctctttttta gcttcttttt caaagttatc
    18901 taagaaagtt ttgcgagcaa cttcaggagt tcctgcttga tgttgagatg gaatagattc
    18961 tgctttttct ttatcaagga agtcactctc aacttcttta agtttatcta agctttctgt
    19021 agtttcgaca gctttcaaac ctgcatctaa tcttgcttta gcgttttctt tttgagcttt
    19081 tttctgttcc ggactcaacc atggatctgt ttcaatagca tcctgagtct ttttatgaat
    19141 ttcttggagt ttttgcgttg ctgagtcaac ttcttttttc tgatcgcctt tgatgtgctt
    19201 gtttggaata gatgtttcat cctcattacc aacggatttt tccacaactt gtttcaaatt
    19261 aattaaacta tcagcagaac taatatcctg aattccattt tcataagctt gagttgcctg
    19321 agcagtttgt ttttgtttat cttcatcact caaccaattg tcttgattaa tatttgagat
    19381 tgtatcatca taaacttttt tcaaattaac tttttcttta gacttaatct cttcttgatt
    19441 tccaggtata tactgattag gaattgaatc agggtgtttc tctgtatctt tacttacata
    19501 gttattaaac ttttcttcat gtgtagcaaa atcttgtgaa ttttggagtt ctttagctcc
    19561 cttttcaaat gctttttgag ctgcagtcaa ttgcattttt ttagctccgt ttgagagcca
    19621 attatcttct ttaatagcaa tttgagtgtc taacaatgtt tttttaaggt tcttcaagcc
    19681 atcttcacga actttttgct ctttatttcc cttataaatt ttacgtaatt tatcctgctc
    19741 cgacggagat tttgataaca aatcctgtaa actgttcgtc tcacttaaat tattctctgc
    19801 ctctgtttta acagaatcta ataatcgttg ttcttcttgc ttctgacttg tgctagacca
    19861 cttatcttgt acaattttat tcttctctgt atcatagaca gattgtaatt tttctttttc
    19921 ctgagagact tttgcttctt ttttaccttt tttatattga tcaggtatag agatgttatt
    19981 tccctcggta gaatactttt tcaagacatc atgtattgtt gtcaatgttt ttgccttgtt
    20041 aatttcagac tcaccttcag tataagttct ttcaacttct gaagtttgat ctcgcttttc
    20101 atcatctgac agccaattat ctaagtctat ttgcttaatc gtttttttct taatatctaa
    20161 taacgattgt ttagctaaat caatatcttt tttatagtca cgatcctcta tcaagcgaac
    20221 agtaacctta cccgaagtat tttgccccca tttttcagca gtataattaa gaacaaaaga
    20281 atcatcaaca gtagttatca ctttatctgg attatcaatt ttagaccaag tagatttgac
    20341 aggattatta aaatgggcgc tatcagtaac tagagaatca agaatttttg aaacttctgg
    20401 tatttcattt actattgatt gtatagattt attttctact ttcgataact ttaattccaa
    20461 ttctttattt tgagggacta atttaggagt atctggaact aaaatagcat ctttaatgat
    20521 ggctgctgaa ttattttttc catcaactct gttatcccta taaacataca tggttaattt
    20581 tccttcagaa ccttcacctt gataaacatg tttcttgttt gaagttacta atctcatctc
    20641 atgagtataa agtttgttac ttttggtttt ttcgtaatat tctccagttt tcacagcacc
    20701 tttatagcct aatcttaccc aggtcatttg atgtgccaaa ttaactctta gagtataatt
    20761 agtattacta taaacaggcg cagatatttc aatacctcca tttgtagaac taccaagaat
    20821 tcctactcta agaactggtg ctttcacatc attatcataa tattttctct ggtcagatcc
    20881 tgcagcatgc tttgaataag ttttgtcaac ttccggtccc cataaaaccc gctttgaggt
    20941 atcagaacct tctggatttt gtttgacaaa actaacagtt ggcaatttac ttacttcttc
    21001 tgaaacttcc gcagccttta cgaccatcac gccattagat tggctgaatg cagtaggtac
    21061 ggcaactccg aggccgactg ttaaaagcat acatgaacta acaaagagtt ttttgacctt
    21121 acgcattctc caattttttt gtttcacatc ttggtgtttt aaaaacattc tgtattcccc
    21181 cttatttttt catgcctatc ttatttgacg ttgtcagcca gtagacaccc agactgactg
    21241 atgacgtgct ctactcttgt agagagttta cgttcctatc acagaattta aggaatcctc
    21301 cttaacttat cttagtcacc gtagaaacct gtattttcta tgttcagaca gtttaacacg
    21361 ccccggaacg ttacagctga ttagaattta aatgaattgt taatttttct aatcaactta
    21421 ttatatcaac ttaaatttac ccaattcaat agatttttta tcaatcccga cgctttttca
    21481 tacctaaaat taagaatatt cagctgcatt ttgcttatat ctgacattct caatactcct
    21541 taaacacgcg tcaccattga attatttgac tgttttattt aattatgtga taattaaata
    21601 aatacgagtt tctgctataa aaatgaaagg agttcagtta tgttacacct tcatctagaa
    21661 accaaattac aagataaatt atcactgctc aacattttgt tagacgtttc cgaagtctcc
    21721 atagaccagt tgtgtcagga aaccgaactc aaaaaacaac gtgtctacaa cttactcatt
    21781 gaaatgatta aggatttaga agacaccctc accttaacca tttgtgacga cactgtttct
    21841 atcccctata agacctacca acttaaaatg ccttatttta agaaactcta tcaaacctcg
    21901 atattcttaa agatgttatg ttttttaatt gaaccaggag agctgagcct acacgacttc
    21961 attaaacgag agtatatttc ccaagccacc gcttaccgta tcaggaccaa ttgtcggaaa
    22021 tacttgaaaa aggtaggttt aaacgttcgg caaaaccatg ttgttggacc agaataccgt
    22081 atccgctttc tgatcgcctt gttgcactat cagtttggta tgaccattta tgattttgat
    22141 aaaacatcaa tgaataaagt ggtttcgctg attataaact ccaatcaagc catcacactt
    22201 aatgatgcca gtaaagcccc ttatgaattt tcatactttg ccattctgat atcccttata
    22261 tggaaacggc gacatgataa cttggggatc cctcagacag atgcattcaa acacttgaaa
    22321 aaactgtcta tctatcacga tatcaaaatg accagtcagg aaatcatcgg aaaatggtac
    22381 catcctgatt taactgatga ggatttggat tatattttct tatgtttttg caccaccaat
    22441 aatgctttcc ataaggataa atggacacct aaaaaagtga aagaattgtt tgagttggtg
    22501 atgacaaaaa caaatggaaa aaccttgaaa gcatccctgc gtccactact aggcgataat
    22561 atcctaaact cccttccttt caaacggatt ttggtttcct tctcacgtct ctttatcagt
    22621 aatcttcaag ttttgttacc tgatatacac ttgttccatt acctcagaag acagcaaaaa
    22681 cgaaacaaga gcttctacaa tactctaaaa accatcgttg aggaatggat gagcgcagaa
    22741 ggcatcgtgg ggaaactgcc gtcctatcat ttactgctct tcacgataca gttagaggaa
    22801 ctcctaaaaa catatttgcc accgatacct gtctatcttt tgaccaataa cactgctgcg
    22861 ctggatttga tgaccaatgc actctcaatt tacttcccgc cagctattgc aacggttatg
    22921 cctgtcaatg tcgaaatcat tcctttcaaa gatattgtta aggaaaagca gagtgtcatt
    22981 atcgcagata ggcaatacct gaacttgata cagcatttgt accagaatca agggcatttg
    23041 ttcttgtatt tcttgtttag ttttagagac gtttctgagg cttacattca taaggcattt
    23101 ctagacttcc gccaaaaacg gtacgatgag tttatcgtga ccttgttgga cacttaccac
    23161 aagaacctgt cttctccttg agtgataaag atgctttgtt cacattacca aaaggctcag
    23221 caagctaata ttgttctaaa cggcatccac aaggtgaggg aactgaacgc aagagtcaac
    23281 tgcagtaatt tgagaaatac cgttcgactg atggattgtt agggcattga gattattaag
    23341 aagaaacagt atcagactta ttcttctaga ataaaggaaa aaatcattaa taacattttg
    23401 aaaaacggct atactattgt ttaaaaggca aaagggagac catcacaaca ggagtctatt
    23461 ctcgtcggct tcggtccttc cttgagaaaa atggctacgc ttatacacaa ctcaatcctt
    23521 tagaaaatta gatagtctac gggtgcgtaa agcggataag ttagacactg aaaaattggc
    23581 tcagtctcaa tttattctag ttagaaaacc aacttacgtt caggaagaaa tttatcagct
    23641 gctacgtgac ttgagtcgct tctatcaaaa cttgactgag gataatattg ttcgagagtt
    23701 aagaatcgcc ttcacaagat cttacaagtc acttttaacg tatctctgac aagcgtggga
    23761 tctacttagt ggaaaaactt gtctc
//
