LOCUS       NZ_CP035435            22835 bp    DNA     circular CON 13-OCT-2024
DEFINITION  Streptococcus pyogenes strain emm64.3 chromosome, complete genome.
ACCESSION   NZ_CP035435
VERSION     NZ_CP035435.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1779766)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Atlas of group A streptococcal vaccine candidates compiled using
            large scale comparative genomics
  JOURNAL   Nat. Genet. (2019) In press
REFERENCE   2  (bases 1 to 1779766)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2019) Department of Microbiology and Immunology,
            University of Melbourne, The Doherty Institute of Infection and
            Immunology, Melbourne, Victoria 3000, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005161325.1-RS_2024_10_12
            Annotation Date                   :: 10/12/2024 01:25:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,787
            CDSs (total)                      :: 1,698
            Genes (coding)                    :: 1,645
            CDSs (with protein)               :: 1,645
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 53
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 26 of 53
            Pseudo Genes (incomplete)         :: 27 of 53
            Pseudo Genes (internal stop)      :: 16 of 53
            Pseudo Genes (multiple problems)  :: 13 of 53
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:28:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1510739
            Orig. end                         :: 1533574
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035435.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22835
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="5"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22835
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22835
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12835](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12835)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    308..322
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.4"
                     /tool="antismash"
     gene            915..2495
                     /locus_tag="ETT64_RS07865"
                     /old_locus_tag="ETT64_07860"
     CDS             915..2495
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982804.1"
                     /locus_tag="ETT64_RS07865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07860"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_136292994.1"
                     /transl_table=11
                     /translation="MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKL
                     LLAVCDNLEKHFNTFTEAQKIFEDAYQDEDLKDDLISVVTGDLGYFIEPTLTFEKLIQD
                     VYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNE
                     IDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTL
                     YDPAMGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNAD
                     TLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSNYGVLAPKSKADFAFLLNG
                     FYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTII
                     ILKKNRTNKDVFFIDASKEFDKSKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEI
                     IENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEA
                     QDELDTFRN"
     gene            complement(2706..2906)
                     /locus_tag="ETT64_RS09410"
                     /old_locus_tag="ETT64_07865"
     CDS             complement(2706..2906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988115.1"
                     /locus_tag="ETT64_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07865"
                     /product="hypothetical protein"
                     /protein_id="WP_063812357.1"
                     /transl_table=11
                     /translation="MPDMKSFLNLVKQKLFKPGLKKLVKLHNSQNVNICLYINDWNYFM
                     VRAMVFVEGSKVVLKISLNRV"
     gene            complement(3048..3653)
                     /locus_tag="ETT64_RS07875"
                     /old_locus_tag="ETT64_07870"
     CDS             complement(3048..3653)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /locus_tag="ETT64_RS07875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07870"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002982799.1"
                     /transl_table=11
                     /translation="MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSK
                     YDIILLDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSKKGFSIKEIEETLQ
                     ISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            complement(3634..5196)
                     /locus_tag="ETT64_RS07880"
                     /old_locus_tag="ETT64_07875"
     CDS             complement(3634..5196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /locus_tag="ETT64_RS07880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07875"
                     /product="hypothetical protein"
                     /protein_id="WP_136292995.1"
                     /transl_table=11
                     /translation="MIRIKNITKSKFFGTAIILLLQLIALLILVYNRENLSLLFSEKVA
                     LVMTLIDTAFIWLATILRQKQGDIFKRIISIISLTIWQYLVSVLTRGTPLFLSSGLQII
                     LLYCYTVEITNLILYGHKQFKDKLDKCLLIIIFVSITSLFVNRILFNFLFLMVFTILHL
                     YPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGSELYGEMLDVNQAFNNLGWYLFP
                     LIMSVIYYFKTIHDKLSFVTQRWLGDYKARIELLFLLLILCWIVLMKVLVKDFLLFFII
                     VDASTLFCLVVISCIFYYLENSKQNFDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNI
                     IAIKNLLSLENSNITHGFIVNELNDLVSGIRDEMDTYHPIVPANQTMKENIQSLFDDIV
                     KSRKSNTLLYFNCSDNMVVPSPYGDIVYRFIKELINNAIKYGDGKNIRLSLTIQSDIII
                     IEESNQVVEKVHSINYGRGLKSFQETLAAFDGDLELQMDTKQFTIRILLPIDWKLCYED
                     FIN"
     misc_feature    complement(5162..5182)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.44"
                     /tool="antismash"
     gene            complement(5236..7143)
                     /locus_tag="ETT64_RS07885"
                     /old_locus_tag="ETT64_07880"
     CDS             complement(5236..7143)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561001.1"
                     /locus_tag="ETT64_RS07885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07880"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_032459919.1"
                     /transl_table=11
                     /translation="MIWSITKSNIKKNFSLYRIYFLATIGLLSIFIAFLNFISDKIITE
                     KIGDSGQALVIANGSLIFLIVFLVVFLIYFNNFFVKKRSQELGVLAILGFSKRELTKLL
                     TLENLVILVLSYLVSLLLGPTLYFLAVLAITHLLNLTMEVQWFITVNEIIESLGILVVV
                     FLINVITNGLIISKQSLIEFVNFSRKAEKKIKIRKVRAIIAITALLLSYILCLATVFSS
                     TRNMLLSIGMVPVSLLIIVLVVLGTVFTIRYGLAFVVSLLKENKKRLYRPLSNIIYPKF
                     NYRIATKNKLLTVLGGLLTVTVSVAGMMVMLYAYSLNGIERLTPSAIEYNVESENGQVN
                     VTTILENDQVSLVDVDLLRLNTNPEVTITESGQTIPYFDIINYSDYKELMKAQGRINSI
                     EGSKSLPLLINYYPTEISLGKTFNLGNAYDVTVKQVSTHNVFSFSTSVTTLVVSDKLYA
                     KLSSCFPEKEMTIRTFNGNSIRSSEAFYNQFSMVPDVISSYSKEYTVKTANIATYIFIT
                     FLSILFIICTGSILYFTSLIEIMENKEEYGYLSKLGYSKKMIHRILRYETGILFLIPVF
                     IGIVNGGMLLIYYKYLFMDTLVAGNIIMLSLLLCLLFFLIIYGTFYVLTLRSVTSIIKN
                     "
     gene            complement(7145..7882)
                     /locus_tag="ETT64_RS07890"
                     /old_locus_tag="ETT64_07885"
     CDS             complement(7145..7882)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000812013.1"
                     /locus_tag="ETT64_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07885"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_032465234.1"
                     /transl_table=11
                     /translation="MNQLLLKNVCKRYPNQPNYALDHINLTVRKGEFVAVMGRSGSGKT
                     TLLNVTSIIDKIDSGNIYCADKEISTFSDKEATSFRKNDIGFVFQDYMLLDSLTIRENI
                     SVALSLKNIDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKEPEII
                     FADEPTGALDLKSSEETMMILSEINKTEKVTILMVTHDVLSASYADRVILLKDGKLHME
                     IDKKDCGESFYDVISQALSDRGE"
     gene            complement(7879..10023)
                     /locus_tag="ETT64_RS07895"
                     /old_locus_tag="ETT64_07890"
     CDS             complement(7879..10023)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887183.1"
                     /locus_tag="ETT64_RS07895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07890"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_136292996.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.6e-22, bitscore:
                     75.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDIPETYFKLKQQVNLGRN
                     GLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRDDAFTIVDPAV
                     GKYVLAKNEFFELSPKFYTEFFYDKATNSSKKIAKRGLVGRNVKEMIFVNRKDTFLTIL
                     YTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFQGGFYFLKNISLVK
                     LQNKFHSTISEKFVTKLLKLPIEYIGKIDKTDIIHRYNGLMIVRELLSERIISIWLDII
                     LMFASISYITYVSTPLGVILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKNSLQTFFSL
                     MDGLFLFKAKNSEKELLSKWDKSFKDYINSTYDRNRYFNLLGAVNYVITFSIPILLILL
                     FLYYSPNSSSGELILLYMMVLNIINPINNILNSIDEILYGVKHYERVLEISTLDDETNG
                     TYKLSEDTDIEINLENINYQYELNGAEVLNGINLKVHSGEFVAIIGKSGSGKTTLAKML
                     LGYVSPSSGDITYNNISYSKIDKTDFRNISAFVSQDSPIFDGDVMYNISLGRESVSGEQ
                     VIETCKRVSIYDDIRSMPMKFHTPLFRDNPSLSGGQKQRISLARELVTTPRILVLDEPT
                     SALDVKTERIIQKNVEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGSHHCLYKNN
                     EYYRDLYDSYMNNYQEEGIK"
     gene            complement(10001..12835)
                     /locus_tag="ETT64_RS07900"
                     /old_locus_tag="ETT64_07895"
     CDS             complement(10001..12835)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /locus_tag="ETT64_RS07900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07895"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_136292997.1"
                     /sec_met_domain="DUF4135 (E-value: 5.8e-79, bitscore:
                     262.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-78, bitscore:
                     261.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRDELKLEYQNHQFYEYVNSIFDYDILDTSIRETSEVLRKKTH
                     KLFYSEFENQLFETIMFLSMKTLVLDINHFSKEIENKSEAYEQYIQQIREENGISNFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNITESLSNVEFSLGDSHSQKQ
                     TVVKIEFKGKSVYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLVKADYCWQLGVAY
                     TNSNKDEVAKIYFKYGVLAAFSEIFSITDLHMGNVIVSGGDLYLIDVETFFQRKLNVQN
                     QNFEGITVDTYQRIYETSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELINKNRG
                     DMKLVKVDYFQEDGFNIPTLNGKVVEPLDYANEIISGFRECYIFLLSQRSKIKEIVGGF
                     PELKSRALFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILHESKHIEQFIVVSEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTVIGNLGETTSLFDNIATLNDERMKFTCELLGIVLKKP
                     IKHWEREKGKSYQFLSISSEHNFSEEILDSIRRIFIDADKNSFSSEEEITWLNIDITET
                     EQWVISPQNITLYNGLIGNALGYLYAYQILGEEQYLVSLNKILKTLETTKNLIETSDMS
                     VFLGKGGLIYLYFSLWKRLKLPQYQKLYLDIIKEFSSQSLEEQNIDYISGVSGLLVVLC
                     NIYNVEQNKTVYYLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGLSHGQSGIAYAL
                     LLSWKINKNYNYFKIAKSAIDFENTRISDGNWIDFRNKGKRSELGMPEPIYWCHGATGI
                     GLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNMELFMNLDDSLKNE
                     VDIEGIILNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQLLRYISNYEVPSLLLLD
                     VPKGSIENEKDYTD"
     misc_feature    12867..12880
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.45"
                     /tool="antismash"
     gene            complement(12919..13074)
                     /locus_tag="ETT64_RS07905"
                     /old_locus_tag="ETT64_07900"
     CDS             complement(12919..13074)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="ETT64_RS07905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07900"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002982773.1"
                     /sec_met_domain="L_biotic_A (E-value: 7.1e-19, bitscore:
                     64.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 5.3e-06, bitscore:
                     23.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFMKNSKDILTNAIEEVSEKELMEVAGGKKGSGWFATITDDCPN
                     SVFVCC"
     CDS_motif       complement(12988..13074)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /locus_tag="ETT64_RS07905_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12919..12987)
                     /prepeptide="core"
                     /locus_tag="ETT64_RS07905_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2306.6"
                     /monoisotopic_mass="2305.1"
                     /core_sequence="KKGSGWFATITDDCPNSVFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /leader_location="[12987:13074](-)"
                     /alternative_weights="2324.6"
     gene            complement(13577..14983)
                     /gene="lacG"
                     /locus_tag="ETT64_RS07910"
                     /old_locus_tag="ETT64_07905"
     CDS             complement(13577..14983)
                     /EC_number="3.2.1.85"
                     /GO_function="GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290548.1"
                     /locus_tag="ETT64_RS07910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07905"
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="WP_136037684.1"
                     /transl_table=11
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYT
                     AEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECH
                     KRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGP
                     IGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKY
                     PFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDF
                     VALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDA
                     PKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRINYVK
                     KHLEVISDVISDGANVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWY
                     KKVAETQVIE"
     gene            complement(15071..16768)
                     /locus_tag="ETT64_RS07915"
                     /old_locus_tag="ETT64_07910"
     CDS             complement(15071..16768)
                     /EC_number="2.7.1.207"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA]"
                     /GO_function="GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263057.1"
                     /locus_tag="ETT64_RS07915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07910"
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="WP_076634368.1"
                     /transl_table=11
                     /translation="MNGLIAQIEKGKPFFEKISRNIYLRAIRDGFIAGMPVILFSSIFI
                     LIAYVPNAWGFHWSKDIENLLMTPYNYSMGILGLFVAGTTAKALTDSMNRSLPSTNQIN
                     FMSTMLAAIVGFLLMAANPAKEGGFLTGFMGTKGLLTAFIAAFITVNVYKTCVKNNVTI
                     RMPEEVPPNISQVFKDLIPFTLSVVLLYVIELIVHSTLGVNVAESIGKLLAPLFQAADG
                     YVGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEINLQLLQAGEHADKILTSGTQ
                     MFIVTMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPLVLNPIF
                     FIPFILAPIVNVWIFKFFIDTLGMNSFTANLPWTTPAPLGLILGTNFQVLAFILAALLI
                     VVDVIIYYPFLKVYDEQILAEEAAGTNSSDALKEKVAANFDTKKADAILEKSAAKETKE
                     ITDQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILPQYQLVILAP
                     QVASNYEDMKVETDKLDIKLAKTEGAQYIKLTRDGQGALDFVKAQFEN"
     gene            complement(16768..17085)
                     /locus_tag="ETT64_RS07920"
                     /old_locus_tag="ETT64_07915"
     CDS             complement(16768..17085)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /locus_tag="ETT64_RS07920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07915"
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="WP_002982760.1"
                     /transl_table=11
                     /translation="MNREETTLLGFEIVAYAGDARSKFLEALKAAQEGDYAKAEELIAA
                     GSDCLNDAHNAQTSLLQKEAAGDDLAYSVTLMHGQDHLMTTILLQDLMKHMIELYKRGA
                     K"
     gene            complement(17109..18092)
                     /gene="lacD"
                     /locus_tag="ETT64_RS07925"
                     /old_locus_tag="ETT64_07920"
     CDS             complement(17109..18092)
                     /EC_number="4.1.2.40"
                     /GO_function="GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768297.1"
                     /locus_tag="ETT64_RS07925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07920"
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="WP_014407847.1"
                     /transl_table=11
                     /translation="MTITLTENKRKSMEKLSVDGVISALAFDQRGALKRMMAQHQTKEP
                     TVEQIEELKSLVSEELTPFASSILLDPEYGLPASRVRSEEAGLLLAYEKTGYDATTTSR
                     LPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDVNEQKKAYIERIGSECRAEDIPFYL
                     EILTYDEKISDNASPEFAKVKAHKVNEAMKVFSEERFGVDVLKVEVPVNMKFVESFADG
                     EVLFTKEEAAQAFRDQEASTDLPYIYLSAGVSAKLFQDTLVFAAESGAKFNGVLCGRAT
                     WAGSVKVYIEEGPQAAREWLRTEGFKNIDELNKVLDKTASPWTEKM"
     gene            complement(18096..19025)
                     /locus_tag="ETT64_RS07930"
                     /old_locus_tag="ETT64_07925"
     CDS             complement(18096..19025)
                     /EC_number="2.7.1.144"
                     /GO_function="GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379688.1"
                     /locus_tag="ETT64_RS07930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07925"
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="WP_023609980.1"
                     /transl_table=11
                     /translation="MILTVTLNPAIDVSYPLDELKCDTVNRVVDVTKTPGGKGLNVSRV
                     LNDFGETVKATGCVGGESGDFIINHLPDSILSRFYKISGDTRTCIAILHEGNQTEILEK
                     GPMLSVDEIDGFTHHFKYLLNDVDVVTLSGSLPAGMPDDYYQKLIGIANLNGKKTVLDC
                     SGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFKALKAVLQDELFEGIEWIIVSL
                     GADGVFAKHKDTFYNVDIPKIKIVSAVGSGDSTVAGIASGLANDEDDRALLTKANVLGM
                     LNAQEKTTGHVNMANYDKLYQSIKIKEV"
     gene            complement(19071..19586)
                     /gene="lacB"
                     /locus_tag="ETT64_RS07935"
                     /old_locus_tag="ETT64_07930"
     CDS             complement(19071..19586)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /locus_tag="ETT64_RS07935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07930"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_014407849.1"
                     /transl_table=11
                     /translation="MKIAVGCDHIVTYEKIAVVDYLKSQGHKVIDCGTYDNVRTHYPIF
                     GKKVGEAVASGKAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNANVI
                     GFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNNPHFFDEFLEK
                     WDRGEYHD"
     misc_feature    19552..19567
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.35"
                     /tool="antismash"
     gene            complement(19621..20049)
                     /gene="lacA"
                     /locus_tag="ETT64_RS07940"
                     /old_locus_tag="ETT64_07935"
     CDS             complement(19621..20049)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982747.1"
                     /locus_tag="ETT64_RS07940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07935"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_011529004.1"
                     /transl_table=11
                     /translation="MAIIIGADKAGQELKEVIKDYLKEGKYEVVDVSENEVRDFVDTTL
                     AVAKEVNASEDNLGIVIDAYGVGSFMVATKIKGMVAAEVSDERSAYMTRGHNNSRIITL
                     GSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC"
     misc_feature    complement(20035..20050)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.28"
                     /tool="antismash"
     misc_feature    20202..20215
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(20203..20216)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     gene            20494..21267
                     /locus_tag="ETT64_RS07945"
                     /old_locus_tag="ETT64_07940"
     CDS             20494..21267
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004270277.1"
                     /locus_tag="ETT64_RS07945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07940"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_011285171.1"
                     /transl_table=11
                     /translation="MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLAD
                     KGLLIRTHGGAQYLDYSSAKDEGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGETVFIG
                     PGTTLEHLAVELKNRNIRVITNSLPVFLILHPSTTIDLILIGGECREITGAFVGAIAIN
                     NLESLTFSKAFVSANAVYNNSIATYSDLEGEVQRVALNNAVEKILLVDSTKFESYDFYN
                     FYQLDQVDLIVTDKNVTTDIIEKYKKFSKIIIADK"
     misc_feature    complement(21836..21854)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            21928..22215
                     /locus_tag="ETT64_RS07950"
                     /old_locus_tag="ETT64_07945"
     CDS             21928..22215
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255538.1"
                     /locus_tag="ETT64_RS07950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07945"
                     /product="DNA-damage-inducible protein J"
                     /protein_id="WP_002988079.1"
                     /transl_table=11
                     /translation="MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVV
                     VTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQGKFYTSEEVRAELGL"
     gene            22205..22540
                     /locus_tag="ETT64_RS07955"
                     /old_locus_tag="ETT64_07950"
     CDS             22205..22540
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048651.1"
                     /locus_tag="ETT64_RS07955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT64_07950"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_038432559.1"
                     /transl_table=11
                     /translation="MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDI
                     EKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKDYIILYHIEGEENRVVIDYLLPTQS
                     DYIKLFK"
ORIGIN
        1 ccagccaaga ttttttatct atctcagatc ttaaagagaa cttgaaattt actgtatatt
       61 cgctatataa actcttacaa aaggaactaa atcaattaca aggaacgtca attaaaggta
      121 tcacaaaagg gtatctcctt tctaaaacga tacttatccc ctctctcccc gaacaaggag
      181 ccattggcga gctcttccaa acggttgatc aactgcttca gttacaggat caaaagctag
      241 caactctaaa agaacaaaag caaaccttcc tcagaaagat gttcccagcc caaggacaaa
      301 aagtccctga aattcgttta caaggttttg atggtgagtg ggaagagaat aaactggggg
      361 aagtatctcc attaaggggt ggatacgcat ttgaaagtga taaatttcaa tctgatggaa
      421 ttaaaatcat aaggatttct aatattttat cttcaggaat tattggtgga gaatttgctc
      481 actaccacca aattaataat gatgataagt atttacttac tgggggatct gcactaatag
      541 caatgtcagg agccacaaca ggaaaagttt ctatattaaa tactgaggaa aaatactatc
      601 aaaaccaacg ggtaggatat tttatggatt taaataaaat tcactataac tttattatag
      661 cttttctaaa atcattaaat tttaacaaac aaattcaaag tgtattagtt gcgggtgcac
      721 aaccaaacat ttcttcaaaa gagatagata atttccaaat tttatatcct cgtcataatg
      781 ttgaacaaga agccattggt aatttcttcc aaaccttaga ccaacaaatt agtcaaacag
      841 aagaaaaact aacagaactt aaagcactta aacaaacatt actcaatcgt ttattcgtat
      901 aagaaaggac gcacatggca gagaaaacaa cttcactccg gcaagcacta tggcattcgg
      961 ccgatcaatt acgtggccaa atggatgcca atgactataa aaactatctt cttggactta
     1021 ttttttacaa acacttatct gataaattac tcttggctgt ttgtgataat ttagaaaaac
     1081 actttaatac ctttacagag gcccaaaaaa tctttgaaga tgcttatcaa gatgaagacc
     1141 taaaagatga cctcatttct gttgttactg gtgatttagg ttactttatc gaaccgacac
     1201 tgacctttga aaaactcatc caagatgttt atcacaatac tttccaatta gaatcattag
     1261 ctcaaggttt tcgcgatatt gaacaaagtg gtgaagactt tgaaaactta tttgaagata
     1321 ttgacctcta ctctaaaaaa ttaggctcta ctcctcaaaa acaaaatcaa accatttcta
     1381 atgtcatgaa aacattaaat gaaattgact ttgaggcagt agatggggat actttaggtg
     1441 atgcttatga gtacttgatt ggtgaatttg ccagtgaatc aggaaaaaaa gcaggtgagt
     1501 tctatacccc acaagctgtc tctcacttaa tgactcagat tgtcttttta ggtcgtgaag
     1561 atcaaaaagg aatgaccctc tatgaccctg ctatgggatc tggatcactc cttttaaatg
     1621 ctaagaaata tagtaaccaa tccgataccg tttcttacta tggtcaagaa atcaatactt
     1681 ctacttataa cttggctcgt atgaacatga tgcttcatgg cgttgccatc gaaaaccaac
     1741 acttaagtaa cgctgatacc ttggatgcag actggccaac agatgagcca accaactttg
     1801 atggggtgtt gatgaaccca ccttattctt tgaaatggtc agcgactgct ggtttcttaa
     1861 cagatccacg gttttcaaat tatggtgtat tagcaccaaa atcaaaagcc gattttgcct
     1921 ttttacttaa tggtttttac catttaaaaa atacaggaac tatggcaatt gtcctaccac
     1981 atggtgtcct tttccgtgga gctgcagaag gtaaaattcg ccaaaaatta ctcgaacaag
     2041 gggctattga tactatcatc ggactcccat caaatatctt ttataataca agcatcccta
     2101 cgactattat catattaaag aagaacagaa ccaataaaga tgtcttcttt atcgatgcct
     2161 caaaagagtt tgataagagc aaaaatcaaa acacaatgac agatagccat atcaaaaaga
     2221 tccttgatgc ttataagagt cgtgataatt ctgataagtt ttcatactta gcctcatttg
     2281 atgaaatcat tgaaaatgac tataacttaa atatcccacg ctatgttgat acctttgagg
     2341 aagtccccgt caaaccactg ccagaattag ctaaacagct cagtgacatt gatcaagaaa
     2401 ttgccaaaac aaatgccaaa ctagatcaac tcatgaaaca actagtcgga acaaccaaag
     2461 aagcacaaga cgaattggat acttttagaa actaaaagac aaaaaaacac cacagtagat
     2521 gattactact gtggcgtttt atttaaaatt gagtagtgaa cctttattga gtacttatca
     2581 tacaagattc tccttcttca cctataaatc aaaatagaat catctcatct aactttgtcc
     2641 gttttctttg ttttatttaa aatagttatt tgaagttaca atgatttctc aaacgtttag
     2701 aaagcttaaa cacggttaag agaaattttc aggacaactt ttgatccttc cacaaaaacc
     2761 atggcgcgaa ccataaagta gttccaatcg ttgatatata agcatatatt aacgttctgg
     2821 gagttgtgaa gctttacgag tttttttaga cctggtttaa acaacttttg tttgactaaa
     2881 tttaaaaagc ttttcatatc aggcatttcc ctacttttta taaaagcgtt atctcaatca
     2941 atttcaatca aaaagaactc aaaaacaatg agtttaaatc tgggtattta acaggaaatc
     3001 cctagcaacg acacaagtaa aacttatgtc gtttgattat ctgcaactca gaaatccata
     3061 aaatacccta attgttcggc tttgtagata gcctcttgct tattatttac caaaagcttt
     3121 gagtagatgt gggtcaaatg attaaatact gttctcctac taatttgtaa cgtttcctct
     3181 atttctttta tagagaatcc tttcttactc aaatttaaga tagctatttc ctggtcagtt
     3241 aaagattcaa cataatcctg agattcgatt tgttcaaaat acttttttcc agaatccact
     3301 ttttttaaga tagaaatgag ttgtttaggg tctatatttt tatctacaaa accgtatgct
     3361 cctacttttt ttgccctctc tctatagatt gatttaacat atcctgtcaa cataacaact
     3421 ttcaaatgag gagtagactg tatgagttct tttgctatct ccaatccatt ttctttagaa
     3481 atatttgtta aattaatatc aagcaatata atatcgtact tagacaaatc aatcgtcaca
     3541 tcgttaaaat gagaagtaat cgtatctatg acatctactt catcatactg ttggaataac
     3601 agttggatac tctttgcaaa tagtctgtgg tcatcaatta ataaaatctt cataacacaa
     3661 tttccaatct atgggaagta atattctgat agtaaattgt ttagtatcca tttgtagttc
     3721 tagatctcca tcaaaagctg ctagtgtttc ttgaaatgat ttcaatcctc tgccataatt
     3781 tatagagtgt actttttcca ctacttgatt gctctcctca atgataataa tatcagattg
     3841 aatcgttaaa gataaacgaa tgttttttcc atctccatat tttatagcat tgtttattag
     3901 ctcttttata aacctataaa caatatctcc atatggggat ggcactacca tattatctga
     3961 acagttaaaa tacaataagg tattactttt tctactttta acaatatcat caaaaagaga
     4021 ctgtatgttt tctttcattg tttgattagc gggaactatt gggtggtaag tatccatttc
     4081 atctctgata ccagaaacta aatcattcaa ctcattaaca ataaaaccat gtgttatatt
     4141 actattttct agagaaagca agttttttat cgctatgata ttttgtaaaa catcatcatg
     4201 caaataattt gagaactcca ctctcatgtt ttcctctgat ttcataaaat agttcagtct
     4261 tctattttca tagtcaaaat tttgtttgga gttttctaaa taataaaaga tgcaagaaat
     4321 taccactaga caaaataacg tgcttgcgtc aacaattata aaaaataata aaaaatcttt
     4381 aactaatacc ttcatgagta caatccaaca aaggataaga agtagaaata atagttctat
     4441 acgagctttg taatcaccta accatctttg ggtaacaaaa ctcaatttat catgtatggt
     4501 cttaaaatag tatattacac tcattataag gggaaacaga taccatccca aattattaaa
     4561 ggcttgatta acatctagca tttctccata aagttcacta ccaagtatta ccagcaaaag
     4621 taaagaaaat agtatcaatg aacgtctaac aactgatatt tgttgcctaa aggacctata
     4681 atatagcact ataactagta acggatacag gtgtaaaata gtaaaaacca tcaggaataa
     4741 aaaattaaat aaaattctat taacaaaaag gctagttata gaaacaaaaa taattattaa
     4801 caagcactta tctaacttat ctttaaattg tttgtgccca tataatatta aattagtaat
     4861 ctcaacggta taacaataga gcaatataat ctgtagtcca ctgcttaaaa agagaggagt
     4921 tccccttgtc agcacagata ctaagtattg ccaaattgtt aaggagatga tagaaataat
     4981 ccttttaaaa atatcacctt gtttttggcg taatattgtt gccagccaaa taaaagctgt
     5041 atcaataagg gtcattacaa gagctacttt ttcagagaaa agcagagaca ggttctctcg
     5101 attatagacc aaaattaaca aggctattaa ttgtagcaac aagattattg cagtcccaaa
     5161 gaacttactc tttgttatgt tttttattct tatcatatta tttacttaat cgttaaagtt
     5221 aaaagatttt taaaattaat ttttgattat ggatgtcact gaccgcaatg tcaatacata
     5281 aaatgtgcca tatattatca agaagaaaag cagacaaagc aataaagata acattatgat
     5341 attgcctgct accaatgtat ccatgaataa atatttatag taaataagca acataccacc
     5401 atttacaatc ccaatgaata caggaataag gaaaagtata cctgtttcat atcgaagaat
     5461 ccgatgaatc atttttttac tataacctag cttacttaga tagccatatt cttctttatt
     5521 ttccatgatt tcgatgaggc ttgtaaagta cagaatacta cctgtacaaa taataaagag
     5581 tatggatagg aaagttataa agatataagt cgcaatatta gcagtcttta ctgtgtattc
     5641 cttactataa ctactgataa catcaggaac catactaaac tgattgtaaa atgcttcact
     5701 tgacctaatc gaatttccat taaaagtcct aattgtcatt tctttctctg gaaaacaaga
     5761 actaagttta gcatataatt tatcagaaac aaccaaggtc gtgacacttg tagaaaaact
     5821 aaaaacatta tgcgttgata cttgttttac agtaacatca tatgcattcc ctaagttaaa
     5881 ggtttttcca aggctaattt ctgttggata ataatttatt aacaatggga gtgacttact
     5941 accttcaata gaatttattc tcccttgagc tttcattaac tctttataat cactgtaatt
     6001 aattatatca aaataaggaa ttgtttgccc agattctgtg atagttactt ctgggttagt
     6061 gttcaatctc aataggtcaa catcaaccaa gctcacttgg tcgttctcta aaatagttgt
     6121 aacattgact tgaccgtttt ctgattcaac attatattct atggcagatg gagtcaacct
     6181 ctctatccca ttaagagaat aagcatagag cattaccatc attccggcaa ctgaaacggt
     6241 tactgttaaa agacctccca agactgttaa taatttattt tttgttgcaa tacgatagtt
     6301 aaatttggga tagatgatat tagacagagg acggtataac ctttttttat tttcttttaa
     6361 caacgaaact acaaaagcca atccatatct gatggtgaac actgttccta aaacaactaa
     6421 gacaattatc aatagagaaa ccggtaccat ccctatgctt aatagcatat ttcgtgtgga
     6481 tgaaaacact gtcgccaaac ataaaatata tgacaatagc aatgcagtga tagcaataat
     6541 agctctgact tttcttatct taattttttt ctcagccttt cttgagaaat taacaaattc
     6601 aatcaaagac tgtttactaa tgataagtcc atttgtgatg acattaatca gaaaaactac
     6661 gactaatatt cctaaagact ctataatctc attaactgta ataaaccact gaacttccat
     6721 tgttaaattc aatagatgag taattgccag tacagctaaa aaatataaag tcggtcccag
     6781 caataaactt accaagtaac tcagaactag aataacaaga ttttctaaag ttagtaattt
     6841 tgttaattct ctttttgaaa accctagtat tgctaagact ccaagctctt gactacgttt
     6901 ttttacaaag aaattattga agtaaattaa gaataccacc aaaaatacaa tcaaaaaaat
     6961 caatgaccca ttagcgataa ctagagcttg accactatcc ccaatttttt ctgtaatgat
     7021 tttatctgag ataaaattta gaaaagctat aaaaatactt aataaaccaa tcgtagctag
     7081 aaaatagata cgatataacg aaaaattttt tttaatgtta gattttgtaa ttgaccaaat
     7141 catattactc tcctctatcg gataaagctt gactaattac atcgtaaaac gactctccac
     7201 aatctttttt atcaatctcc atgtgaagtt tcccatcttt gaggagtata actctgtcgg
     7261 cataagaagc tgataaaacg tcatgagtaa ccattaaaat agttaccttt tctgttttat
     7321 tgatttcact caaaatcatc attgtttcct cagaagattt caagtcaagt gctccagttg
     7381 gttcgtcagc aaaaataatc tctggttctt taatgattgc tctgataata ctgaccctct
     7441 gtctttgacc tccagaaagt tgatacggat atttcttcaa ctgttcatat aaattaaatc
     7501 tttttgcata gctatttatc aaatcatcaa tctttgaaga atcaatattt tttagagaca
     7561 aagcaacaga aatattctcc ctaatggtta gactatctaa cagcatataa tcttgaaaaa
     7621 caaaaccaat atcatttttt ctaaaactag ttgcctcctt atcagagaat gtgctaatct
     7681 ctttatccgc acaataaata ttcccactat caattttatc aataattgaa gtaacattta
     7741 aaagtgttgt ttttccacta ccactacgtc ccatgacagc tacaaattct ccttttctaa
     7801 cagtcaaatt gatatggtct aaagcataat tcggttggtt tggatacctt ttgcaaacat
     7861 ttttcaatag taattgattc attttatccc ttcctcctga tagttgttca tgtacgaatc
     7921 atataaatca cgatagtact cattattttt atataaacaa tgatgactac catagtcaat
     7981 aattttccca ttatccatta ttaaaatctt atcagctttt tcaactgtat taagtctatg
     8041 ggtaaccaaa accctcgtac aatgtaaagc ctcaacattt ttttggatta ttctttcagt
     8101 ttttacatct aaagctgatg taggttcatc aagaactaag attctagggg tagttactaa
     8161 ctctcttgct agagaaattc gttgtttttg ccccccagat agtgatggat tatctcgaaa
     8221 aagtggtgta tgaaacttca ttggcatact cctgatatca tcatatattg ataccctttt
     8281 acaagtttca ataacctgtt ctcctgaaac agattctctc cctagcgaaa tgttatacat
     8341 cacatcccca tcaaatatgg gagaatcttg agatacaaaa gccgatatat tcctaaaatc
     8401 agttttatca attttagagt aggatatatt gttgtatgtg atgtctccac tactagggct
     8461 tacatagcct aacaacatct tagctagagt tgtctttcca cttccacttt tccctataat
     8521 tgcaacaaat tctcctgaat ggacttttag gtttattcca tttaacacct ctgccccatt
     8581 taactcatat tgatagttta tattttctaa atttatctct atatctgtat cctctgatag
     8641 cttataagtg ccattcgtct catcatcaag agttgatatc tctaataccc tttcgtaatg
     8701 cttaacacca tatagaatct catcaatcga attcaaaata ttattaatgg gattaataat
     8761 atttaaaacc atcatataaa gaagaataag ctcaccactg ctactatttg gtgaataata
     8821 tagaaataac agaattaaca aaataggtat ggaaaaagtt atcacataat ttactgctcc
     8881 taaaagattg aaatatctat ttctatcata tgttgaattg atatagtcct taaaactttt
     8941 atcccatttt gacaaaagtt ctttttcaga atttttagct ttaaaaagaa atagcccgtc
     9001 catcagtgaa aaaaatgttt gtaaagagtt cttttgtctt aaaacttctt tacctaactt
     9061 ttcttgttta atgcttagtg ataggaaaaa aatcatcatt tctacaataa aaactatacc
     9121 caatataact cccaaaggtg tagaaacata tgtgatataa ctaatactcg caaacattaa
     9181 gataatatcc aaccaaatag aaataattct ttctgatagt aactccctca caatcatcaa
     9241 accattatat ctatgaatga tgtctgtttt atctattttt ccaatatatt ctatgggaag
     9301 tttcaataac ttagtcacaa acttttctga aatagtgctg tgaaatttat tttgcaattt
     9361 cactaaagag atattcttta gaaaataaaa tcctccctga aaaaaaatta ttatagaaag
     9421 taggactgca ctttctaaat agccaaactt tttaaggaaa acccaatttc catcaataat
     9481 tccccttata aaaaatggaa ttgacactgt gataatctga aaaatcagag tatatagaat
     9541 ggttaaaaaa gtatccttcc tatttacaaa tatcatttct tttacgtttc tgccaactaa
     9601 tcctcgtttg gctatttttt ttgaagaatt agtcgcctta tcataaaaaa attcggtata
     9661 aaatttagga gataattcaa aaaattcatt ctttgctaag acatatttcc caacagcagg
     9721 gtcaacaata gtaaaggcat catcacgaat atcctctaaa attacaaaat gcgaatctga
     9781 aacaaatacc atgacaggta agttttcggg atatttggaa aaacgataag tcttacaagt
     9841 aactccgtag atagaagcaa tatctgagat attctttata ctcagtccat ttctccctaa
     9901 attgacttgt tgtttcaatt taaaatatgt ttctggaata tcaaaataat ctaacatcat
     9961 atataaacaa cataatccac attcagtagg agttgtttgt tcaatcggtg taatcttttt
    10021 cattttcaat actccctttt ggaacatcta ataacaataa tgatggtact tcataattgg
    10081 atatatatct aagtaactgg tatgctatcc ctatttcacc aaccatcata ttaaacactc
    10141 ttgtgtgttg tggcaagcca gattcccaac caaatttttg agaattacga acaatattaa
    10201 gtatgatacc ttctatatct acttcatttt tcaaggagtc atctaaattc ataaataatt
    10261 ccatgttgcc cattttcccg tgacaaaggc aatccgaatt caaataacca ttatttaata
    10321 ccgtttgttt agccatttca taattatttt tcaactcttt atcgtttaac cattttgatt
    10381 ctctatatct cgttaatccg atacctgttg caccatgaca ccaataaata ggttctggca
    10441 ttcctaactc tgaacgtttt cctttatttc taaaatcaat ccaatttcca tcagaaatac
    10501 gggtattttc aaaatcaata gctgacttcg ctattttaaa ataattataa tttttattga
    10561 ttttccatga taaaagtaat gcatatgcaa tcccagattg tccgtgagat agtccattta
    10621 gaatttctga atctgaaaaa tccgataccc aataaacctt atcatcttct tttttcacat
    10681 tatcaataat aaattcagat atcctattaa ttaaataata tactgtttta ttttgctcta
    10741 cattatatat gttgcacaga acaactaata aaccagacac tccagaaata taatctatat
    10801 tttgctcctc tagtgactgg ctggaaaatt ctttgattat gtctaaatat aatttttggt
    10861 attgaggtaa tttgagtctt ttccacaaac taaagtatag ataaatcaaa cctccttttc
    10921 ccaaaaaaac tgacatatca ctagtttcta taagattctt tgtggtttcc aatgttttca
    10981 atatcttatt taatgatact agatattgct cttcaccaag aatttgataa gcatataaat
    11041 aacctaaggc attcccaatc aatccattat acaaggtaat gttctgagga gatattaccc
    11101 attgctcagt ctctgtaata tcaatattga gccatgttat ctcctcctct gaagaaaagc
    11161 tattcttatc tgcatcaata aatattcgtc taatgctgtc taagatttcc tcactaaaat
    11221 tgtgttctga ggagattgat aaaaactgat aagatttgcc cttttccctc tcccaatgct
    11281 taatcggttt tttcaagact attccaagca attcgcaagt gaacttcatt ctttcatcat
    11341 tcagggtagc tatattatca aataatgagg ttgtctctcc tagatttcca attactgttc
    11401 ctaaagaatt atatacattt ccactggtat ccattgaaaa gtaaggaata tcaccattca
    11461 tcaaatcttt aatttcacta acaacaataa attgttcaat atgttttgac tcatgtagta
    11521 tcgaaaataa attctccctc tttttttctg agaaaagata ttttggattc gtagaagctt
    11581 gcaaaaattt tccatagtcg gaagtatttc gaaatagggc tctgcttttc aattctggaa
    11641 aacctcctac tatttcttta atctttgaac gttgtgatag aagaaatatg tagcactctc
    11701 taaatcctga aatgatctca ttagcatagt caagaggctc taccactttc ccatttaatg
    11761 tgggaatatt gaacccatct tcttgaaaat agtcaacttt tactaacttc atatctccac
    11821 gatttttatt tatcagttca tattttcctt tttttctttt tccacctttt ccacttattc
    11881 cagaaacgtt aggagcgctg tttttctcaa attgtacagg aaataaaccg tttgaaagtg
    11941 atgtctcata aattctctga taggtgtcta cagtaatccc ttcaaaattc tgattttgta
    12001 cattcaactt tctttgaaaa aatgtttcaa cgtcaattaa atataaatct ccacctgaaa
    12061 caatcacatt tcccatatgt aagtccgtaa tagaaaatat ttcagaaaat gctgctaaaa
    12121 caccatactt aaagtaaatt ttcgctactt catctttatt ggaatttgta taagctacac
    12181 caagttgcca acaataatct gctttaacta agctttcagg aagactgaac gaaggtatat
    12241 tattagattt caatagacta ataagttcca acaagatgtt gtatgaatca tagcttttag
    12301 gcttgtagta aacggatttc cctttaaatt caatcttaac gactgtttgt ttttgggaat
    12361 gactgtctcc aagtgaaaat tcaacattac ttaaggactc agtaatatta aagcatgacc
    12421 ttatttcaga caaatctttt aaaaacctat caaatagcaa agagtatgat tccactacca
    12481 atccaacttc tctattgatt tgttttagca aatatggata tctgtcaaaa aaattactta
    12541 tcccattttc ttctcttatc tgctgtatat actgctcata tgcctctgac ttattttcaa
    12601 tttccttgga aaaatgattt atatctaaaa ctagtgtttt catcgaaagg aacatgatcg
    12661 tttcaaataa ctgattttca aactcactat aaaataactt atgtgtcttt ttccttaaca
    12721 cttcactggt ttctctaata gaagtatcta atatgtcata gtcaaaaatt gagttaacgt
    12781 attcgtaaaa ctgatggttc tgatattcta actttaattc atctcttttt atcatttttt
    12841 tcctaccact acttaaaaat cctgcctaga ctgagtctaa acaggaaatt tttagtctgc
    12901 ttgtccagat tgttttaatt aacaacaaac aaatactgag ttcggacagt catcagtaat
    12961 agttgcaaac caaccggaac cttttttacc accagctact tccataagtt ctttttcaga
    13021 aacttcttcg atagcattag tcaaaatatc ttttgaattt ttcataaaac tcattctcct
    13081 ttccatcagt atgtagtgac tattttctac acttttattg taaataatac gtcttcattt
    13141 tcaatgagta aaaagtgcaa aaatgacttt tttcatattt tttagtaaga tttttgagat
    13201 gtcacataag aggtcacttt ataacaaata gccctctgat ataaaaaaca aaactcgttc
    13261 tttacagcta ttttacaatc taatcgcttc tcgttataac atcaatctct aatcagaaaa
    13321 tggttacttt acttatttaa tcaggtcagg agtttgaatg acagaagtca aatatctgaa
    13381 aaaggatgtt aaataaaact ttcaaaaccc attttcatca actaaaaaca cttataaccc
    13441 gatcttacaa ctaatggatt accatcaaca gcaaataata ctatgcttga aaaatgtcaa
    13501 catcatctac tttttgtgac tataattcag taaacgaaca tgacgtgtaa aaatgtatta
    13561 aaaaagtatc tcaaaatcat tcaatcactt gagtttctgc cactttttta taccagtagg
    13621 cactcttctt aggataacgc tcttgagttt caaaatcgac atagaagaga ccgtaacgtt
    13681 tttcatagcc atttgaccat gagaagacat ccatcagtga ccacataaag tatcctttaa
    13741 catttgcacc atcagaaata acatcagaaa taacttctaa gtgttttttc acataattga
    13801 tacgtccatc atcatagaca gtattatcta caaactcatc tttgtagcca agaccatttt
    13861 cagtgatata aattttcttg taattaggat aatcggcttt gacacgcatg atttgatcat
    13921 ataagccttg tgggaagata atccagtccc agtcagtttt tggagcatca acgggtgctt
    13981 ttcttcgacc aacacccttg atttggtatt tagagctgcc tttttcaccc ttaccattgt
    14041 gaatgatttc agtctcacca tcaaaagctt gcatccaatc actcatgtag tagttaatac
    14101 caaggaagtc attcaaatct tttgcagcgt ctagtgcgac aaagtcttct tcacgaagat
    14161 caagttcacc gccattcacc tcaaggatat ggttaacacc ttccattgtt ttatctgaat
    14221 acttacctag ataagttgca tcaagaataa atttattatg gatgatatct tccagttcag
    14281 ctgctctaac atcatcagga ttgttagcgt caaatggata cttagttgga agagcatgga
    14341 caacaccaat ttcacctgaa taaccactat ctttaaagag tttgactgca cgagcatgag
    14401 agaccatcat gttatggtgt gattggaaaa ctttagcaag atcatattgg atacctggag
    14461 ggaatttacc aactaagtat tgaccatcgc caattggtcc aatttcgtta aatgttgtcc
    14521 aatagttaac ttctgagaat tctttaaaac agaattctgc ataatttaca aaatgttcaa
    14581 tgttctcacg attgaggaaa tcaccatccg agtggagagc ttctggggta tcaaaatggt
    14641 gaagtgtaac aaaaggctca acatgacgct tatgacactc tgcaaagaga ttgtggtaat
    14701 attctacccc tttagggtta acttctcctt ttcctgttgg aaaaatacga gaccaggcaa
    14761 tagagatacg gatgccgttg acaccaaatt cttcactaag tttcaaatcg acagggtaac
    14821 gattataaaa atcacttgct ggttcagcag tgtaccaata gttgtcttct aagtatttat
    14881 cccaagctac tggtccttta ccatctgtgt gggtagcgcc ttcagcctgg taagcagctg
    14941 tagcaccacc aaaaataaaa tctttaggta atgtttttgt catctcagtt tctccttgaa
    15001 tatctttcaa aaataaagtt cccaaaacaa tttttgtgtt tgagaacttt acgacattta
    15061 aactgttttc ttaattttca aactgtgctt ttacaaaatc aagagctcct tgaccatcac
    15121 gggtcaattt gatgtattga gccccttctg ttttagctaa tttaatatca agtttatcag
    15181 tttccacttt catatcttca tagttagaag ctacttgagg tgcaaggata acaagttgat
    15241 attgtggtaa aatctcacgg tgagcaccat aacttcctgc tgctgcagtg acaggtgcac
    15301 catattcttt agctgcttta ttcaaagcat ttgctagtag tccacttgta ccaccaccgg
    15361 cacaaagaac gagaacatta gtttgatcag tgatttcttt ggtttcttta gctgctgatt
    15421 tttcaagaat agcatcagct tttttagtat caaagtttgc tgctactttt tctttgaggg
    15481 catctgatga attcgtacct gctgcttctt cagcaagaat ttgctcatca tatactttca
    15541 agaatgggta gtagatgatc acatcaacga caattaacaa agctgccaaa atgaatgcta
    15601 gaacttggaa gtttgtacca agaatgagac ctaatggagc tggtgtagtc caaggtaagt
    15661 ttgcagtgaa actgttcatt cctagtgtgt caatgaagaa tttgaaaatc catacattga
    15721 caattggtgc caagataaat ggaataaaga agattgggtt caaaacaagt ggggcaccga
    15781 acaagatagg ttcgttaaca ccaaagaatg ttggaacaac tgatgcacgt ccaatggctt
    15841 tgttacgttt tgatttcgtc aaccacatga acatgaatgg aacgacaagt gttgcacctg
    15901 taccacccat ggtaacgatg aacatttgag tccctgaagt caagatctta tcagcatgtt
    15961 caccagcttg aagtaattga aggttgattt cagcatttgc gtaagtaatc gctgcaatgg
    16021 ctggttcaac aatagatggt ccatgaatac caacaaacca gaagaaagca aatgcaccga
    16081 agataatagt gattccaaca tagccatctg ctgcttggaa caatggtgca agaagtttac
    16141 caattgattc tgcaacgtta acgcctaaag tactatgaac aatcaattca atcacataaa
    16201 gcagtacaac tgataacgta aatggaatca aatccttaaa tacttgagag atatttggtg
    16261 gcacctcttc tggcatacgg attgtaacat tgtttttcac acaggtttta tagacattta
    16321 cggtaataaa agctgcgatg aaggctgtca acaaaccttt tgttcccata aatccagtta
    16381 agaaaccacc ttcttttgct ggattggctg ccataagtaa aaaacctaca atagcagcga
    16441 gcatggtaga catgaagttg atttggtttg tgcttggtaa tgatcgattc attgaatcgg
    16501 ttaatgcttt ggctgtcgta ccagccacaa acaaacctaa aatacccatt gagtagttgt
    16561 atggcgtcat caagagattc tcaatatcct tactccaatg gaagccccat gcatttggaa
    16621 cataggcaat caagataaag atacttgaaa acaagataac aggcatacca gcgataaaac
    16681 catcacgaat agcgcgaaga tagatgtttc gagaaatttt ctcgaagaaa ggtttccctt
    16741 tctcaatctg agcaattaat ccattcatta ttttgctcct ctcttataaa gttcaatcat
    16801 gtgtttcatt aaatcttgta ataaaatggt cgtcattaaa tgatcttgac cgtgcattaa
    16861 agtgacacta taagctaagt catctccagc tgcttctttt tgtagtagac ttgtctgagc
    16921 attgtgagca tcattcaagc agtcactacc tgcagcgatt aattcttctg ctttagcata
    16981 atctccttct tgcgctgctt taagcgcttc caaaaatttt gaacgggcat caccagcata
    17041 ggctacgatt tcaaaaccta aaagagtagt ttcttctcta ttcattgtag tttcctccga
    17101 aaataatgtt acattttttc agtccaagga cttgcagttt tatctagtac tttgtttaat
    17161 tcgtcaatat ttttgaaacc ttctgtacgc aaccattcac gagctgcttg tggtccttct
    17221 tcgatataga cttttacaga tcctgcccag gtagcacgtc cacataagac accgttgaat
    17281 ttagcacctg attctgctgc aaacaccaaa gtatcttgga acaatttggc agaaacacct
    17341 gcactcaagt aaatatatgg taaatcagta gaagcttctt ggtcacggaa agcttgagct
    17401 gcttcttctt ttgtaaagag aacctcacca tctgcaaagc tttctacaaa tttcatattt
    17461 actggaactt cgactttcaa gacgtcaaca ccaaagcgtt cttctgagaa gactttcatt
    17521 gcttcattaa ctttatgagc tttaactttt gcgaactctg ggctagcatt atcagagatt
    17581 ttctcatcat aagttagaat ttctaagtag aatggaatat cttctgcacg gcattcagaa
    17641 ccaatacgtt caatgtaagc ttttttctgc tcgttaacat cttgatctcc atcaatatca
    17701 tagtaaagaa ggaacttaac tgcttctgct ccagcttctt taatacgttt tgcagaccaa
    17761 acatctaagc aatcaggtaa gcgactagtt gttgttgcat cgtatcctgt tttctcatat
    17821 gccaacaaca agcctgcttc ttctgaacga acacgacttg ctggcaagcc atattcagga
    17881 tcaagtagaa ttgaggatgc aaatggtgtt agttcttcag aaactaaact tttaagctct
    17941 tcaatttgtt ctactgttgg ctcttttgtt tgatgttgag ccatcatacg tttgagagct
    18001 ccacgttgat caaaagctaa ggcagaaata acaccatcta cacttagttt ttccatgctt
    18061 ttacgtttgt tttcagttaa agtaattgtc attttttata cctctttgat tttaatagat
    18121 tgatataact tatcgtaatt tgccatgtta acatgcccag ttgttttttc ttgcgcattt
    18181 aacatcccta agacatttgc ttttgttaat aaagctcgat catcttcatc attcgctaaa
    18241 cctgaagcaa tacctgccac tgtagaatcc cctgaaccta cagcgcttac aattttaatt
    18301 ttaggaatgt caacgttata aaacgtatcc ttgtgctttg caaatacacc atcagcacca
    18361 agagaaacga ttatccattc aattccttca aatagttcat cttgtaagac tgcttttaaa
    18421 gctttaaaat cttttgtcat ttctttacca agaagttgag aaagttcttc aagattaggc
    18481 ttgataactg ttggtttact atcacctttt agtactgctt ctagagcatt tccagaacaa
    18541 tccagaaccg ttttcttacc attaagattg gcaataccga ttaacttctg atagtaatca
    18601 tctggcatac cagcaggcag actgcctgag agcgtcacta cgtcaacatc attcagtaaa
    18661 tatttgaaat gatgagtaaa gccatcaatt tcatctacac ttaacatcgg tcctttttct
    18721 aaaatctccg tttgattacc ttcgtgtaaa atggctatac aagttctagt atcacctgaa
    18781 attttataga agcgacttaa aatcgaatca ggaagatgat taatgataaa atcaccgctt
    18841 tctccaccta cacaacctgt agctttgact gtctcaccaa agtcatttag aactcgggaa
    18901 acattcaagc ctttaccacc gggtgtcttt gtaacgtcta caactcgatt gacagtatcg
    18961 cattttagct catccaaagg gtaggagacg tcaatagctg gatttaaagt aactgttaaa
    19021 atcacaatag ctcctttttc tatatatcct tatcataatt ctttcaaata ttagtcgtga
    19081 tattcaccac ggtcccattt ttctaggaat tcatcaaaga agtgtgggtt gttttgatct
    19141 tgactagcat gttgcaagct atccattttt tcaatccatt ttttattttc ttcagttggt
    19201 ttgtattccg cggctaagaa agcatcgata atatcattca tcaataaacc accgatgatt
    19261 tttccaccaa aaccaataac gtttgcgttt agctcttctt ttgagtagat agcagatgtc
    19321 atatctctaa cgagtgctgc acgaataccg ggaactttgt ttacagcatt tgtgatacca
    19381 acaccagtac cacagataac aacacctaat tctgctttac cacttgctac tgcttcacca
    19441 acttttttac caaagattgg atagtgtgtg cgaacattat catatgtacc acaatcaata
    19501 actttatgac cttgtgattt taggtaatcc acaacagcga ttttttcata agtaacaata
    19561 tggtcacaac ctacagcaat tttcattttt gttctccttg ttttaaccta tttcaatcaa
    19621 ttagcacatt ttattaagca tgtcgacacg aacttgatga cgtccaccat catatttacc
    19681 ttcgacaaag cctttgataa tgttctttgc aattcctgga gcactaattt cagaaccaag
    19741 cgtgatgatt cgagagttat tgtgacctct tgtcatgtat gctgagcgct catctgatac
    19801 ttcagctgcc accattcctt tgattttagt agctaccatg aaagaaccaa caccatatgc
    19861 atcaatgaca atacctaagt tatcttcgga tgcattaact tcttttgcaa cggctaaagt
    19921 tgtatctaca aagtcacgta cttcgttttc actaacatca acgacttcgt atttaccttc
    19981 tttaaggtaa tctttgataa cttctttaag ttcttgacct gctttgtcag caccgataat
    20041 aattgccatt ttatttctcc tatgatttag aataagtaaa tgtggaaaac ctacgtagat
    20101 agttaattaa cgatttgcaa catcttttga aataacgctt tcattatttc tatgacctaa
    20161 tcatacaccc accaaacata aaagtcaaca ttttcttgtt tatttttata aaaaataaac
    20221 aaaatatgtt tattttttcg tttttacgtt attatcctaa tgtttcttgt gtttcttttt
    20281 catttcataa atcactttga cagccactcg taacctatca tatattacga aacccttatc
    20341 tctatttatt gtaaacgttt tatttaaaac attttctatt ttgttaattt ttgttttttc
    20401 caatgtttat gtttgttttg tttgattttt ttattgatat tatgttatga tacctttaac
    20461 agttataccc taagacactg ataggagata agaatgaaaa agaaagagcg tcatgaaaaa
    20521 attctcgata tcttaaaagt tgacggtttt ataaaagtaa aagatattat cgatgaaatg
    20581 aacatctcag atatgaccgc tagacgagat ctcgatacat tggcagataa aggattactt
    20641 atcaggaccc atggtggtgc tcaatatttg gattattctt cagcaaagga cgaaggtcac
    20701 gagaaaacac acactgaaaa gaaggtctta cagactaccg aaaaaaaaca aattgcacaa
    20761 agagctaaaa acattattaa agacggcgaa actgtcttta taggtccagg gacaacatta
    20821 gagcatctag ctgtcgaatt aaaaaataga aatatcagag ttattacaaa tagccttcct
    20881 gtttttttaa ttttgcaccc gagcactact attgatttga ttttaattgg tggtgaatgt
    20941 cgtgaaatta ctggagcttt tgttggtgct attgccatta ataatctaga atcactaact
    21001 ttttcaaagg cttttgttag cgcaaatgca gtttacaata attctattgc gacgtacagt
    21061 gatctcgaag gagaagttca aagggttgca ttgaataatg ctgttgagaa aatccttcta
    21121 gttgatagta ccaagtttga aagttatgac ttctataatt tctaccaact agatcaagtg
    21181 gacttaattg tgactgataa aaatgtgaca actgatatca tagaaaagta caagaaattc
    21241 tcaaaaatca taatcgctga caagtaaagg acctactcat attaaaatgc acttcagggt
    21301 ttagatatat cccctgtcaa gtaaacaggg agcatatctg aaagtagtgt ttgtgttata
    21361 aagaagtttc ttgctaactt attttctggt ttttttcaga cttatcagtc ttgtactgtt
    21421 cctttttctg atgaataacg tggaaatagg cagacagcta tatatttcac ctctagaatg
    21481 gttgccatta ctgtcatcaa gacatgcttg ttctttatcg tatggagtaa agctttcttt
    21541 tagccatcaa catacctctt aagtagattt tggttcgtta ccatgtctac ttaagaggtg
    21601 tcttcaaagc gctttaaaac gttgatataa cagtatatta acgttttgag aattgtgaag
    21661 ctttacgagc ttttttaaga cctggttttt ggttgatatt ctgatataca taaagatact
    21721 tataaaatca acctattcct ggttcaatca atcaaaatct attaattata tacaaatatc
    21781 ttattcccaa cggtatcaat aaggtatcaa aaataaggtt cggagcttat caaataatga
    21841 aaatctgtct caattaccga gtctttttta ttgacttttt tgtatatatg atataattaa
    21901 ataacttaca taaaggggtt acataaaatg actacagtaa aaaaaaacag agcggttacc
    21961 tttcaagcta acaaagaatt ggtaagcgaa gcaatgacag tattaaacaa aaaaaattta
    22021 accttatcat ctgctttaag attattccta caaaatgtcg ttgtcacaaa cgaggttgac
    22081 ttattgacgg aagaggagtt agagaaagaa aaacttttca agcaatttca agctgaaatc
    22141 aacaaaaata ttgaggatgt tcgtcaaggg aagttttata cctctgaaga agtgagggct
    22201 gaacttggac tataagaaat atcagattat ctatgctcct gatgttttag agaagctaaa
    22261 agaaattcgt gattatattt ctcaaaacta ctcctcaaca tcaggtcagc gtaaaatgga
    22321 gcaaatcatt agcgacatag aaaaactcga ggttttccca gaagttggtt ttgatgccga
    22381 tgaaaaatat ggttcaaaaa tcagtcatta tcacagcact aaaggttata ccttaagtaa
    22441 agattatatt atcctatacc atatcgaggg ggaagaaaat agggtcgtta ttgattactt
    22501 gcttcctact caaagcgact atataaagtt attcaaataa cacgttaaaa gccttagcag
    22561 tcttgctagg gcttttttgg tagattacca attaactagg agcaaaatga gttcgggctg
    22621 tttagtagat attccacaaa gaagccaaag actacgaagc taggctaatc taccttaagg
    22681 cttcaggaaa cttggaggag ttcaccaagc caactcataa aacttatagc gagatattcg
    22741 agaaatggta tcaagcctat caagatacgg tagagccaac cacggcttct cgtactcttg
    22801 atctgtttcg acttcacatt ctgccagtca tggga
//
