LOCUS       NZ_CP035431            20873 bp    DNA     circular CON 15-OCT-2024
DEFINITION  Streptococcus pyogenes strain emm105 chromosome, complete genome.
ACCESSION   NZ_CP035431
VERSION     NZ_CP035431.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1800116)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Atlas of group A streptococcal vaccine candidates compiled using
            large scale comparative genomics
  JOURNAL   Nat. Genet. (2019) In press
REFERENCE   2  (bases 1 to 1800116)
  AUTHORS   Davies,M.R., McIntyre,L., Mutreja,A., Lacey,J.A., Lees,J.A.,
            Towers,R.J., Duchene,S., Smeesters,P.R., Frost,H.R., Price,D.J.,
            Holden,M.T.G., David,S., Giffard,P.M., Worthing,K.A., Seale,A.C.,
            Berkley,J.A., Harris,S.R., Rivera-Hernandez,T., Berking,O.,
            Cork,A.J., Torres,R.S.L.A., Lithgow,T., Strugnell,R.A., Bergmann,R.,
            Nitsche-Schmitz,P., Chhatwal,G.S., Bentley,S.D., Fraser,J.D.,
            Moreland,N.J., Carapetis,J.R., Steer,A.C., Parkhill,J., Saul,A.,
            Williamson,D.A., Currie,B.J., Tong,S.Y., Dougan,G. and Walker,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2019) Department of Microbiology and Immunology,
            University of Melbourne, The Doherty Institute of Infection and
            Immunology, Melbourne, Victoria 3000, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005161125.1-RS_2024_10_13
            Annotation Date                   :: 10/13/2024 02:15:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,766
            CDSs (total)                      :: 1,677
            Genes (coding)                    :: 1,600
            CDSs (with protein)               :: 1,600
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 39 of 77
            Pseudo Genes (incomplete)         :: 46 of 77
            Pseudo Genes (internal stop)      :: 21 of 77
            Pseudo Genes (multiple problems)  :: 21 of 77
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:05:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1178610
            Orig. end                         :: 1199483
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035431.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="5"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20873
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10873](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10873)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    572..586
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.55"
                     /tool="antismash"
     misc_feature    complement(603..618)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.81"
                     /tool="antismash"
     gene            complement(649..822)
                     /locus_tag="ETT68_RS09145"
     CDS             complement(649..822)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983923.1"
                     /locus_tag="ETT68_RS09145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002989134.1"
                     /transl_table=11
                     /translation="MFTIMIIGLAVFSIIKIILFFYFYQQFERKQKRKVESNNQQRQSQ
                     ESDAVPSKKFPF"
     misc_feature    849..862
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.77"
                     /tool="antismash"
     gene            complement(894..2756)
                     /locus_tag="ETT68_RS06000"
                     /old_locus_tag="ETT68_05995"
     CDS             complement(894..2756)
                     /EC_number="7.2.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015662 - P-type ion transporter activity
                     [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0019829 - ATPase-coupled monoatomic cation
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528775.1"
                     /locus_tag="ETT68_RS06000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_05995"
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WP_136110308.1"
                     /transl_table=11
                     /translation="MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAF
                     LIGGYASAKTGILDLVKNKHLSVDILMILAAIGAGIIGYWLEGALLIFIFSLSNTLEEM
                     AMEKSKDAISGLMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQLLS
                     PFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESA
                     QEKKSKTATFIESLEDGYVKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCA
                     LIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVVMDKTGTLTQGKPSVVNAHYL
                     EDELLVNRLVKGAEAASTHPISKALLEYTEKLEPLTFDHLEEISGKGFQGFYQGQEWRI
                     GKKTFILEKVQDLSAFEETIQVEENQGKTLIFVSRDHQLIAYYALLDDIKIESKRAIKS
                     LHAMGIKTVMLTGDQERTANYVAQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGD
                     GINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSIQLSRKMKTIIKQNIVF
                     ALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK"
     misc_feature    2747..2761
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.54"
                     /tool="antismash"
     misc_feature    complement(2806..2819)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 26.23"
                     /tool="antismash"
     misc_feature    complement(2837..2855)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.56"
                     /tool="antismash"
     gene            complement(3100..3375)
                     /locus_tag="ETT68_RS06005"
                     /old_locus_tag="ETT68_06000"
     CDS             complement(3100..3375)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /locus_tag="ETT68_RS06005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06000"
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_002983920.1"
                     /transl_table=11
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVDAVFSTIEAFLAEGEKVQL
                     IGFGNFEVRERAARKGRNPQTGAEIEIAASKVPAFKAGKALKDAVK"
     gene            complement(3474..4061)
                     /locus_tag="ETT68_RS06010"
                     /old_locus_tag="ETT68_06005"
     CDS             complement(3474..4061)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922482.1"
                     /locus_tag="ETT68_RS06010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06005"
                     /product="YpmS family protein"
                     /protein_id="WP_002989129.1"
                     /transl_table=11
                     /translation="MKKKSNLNWWKWSFLCLLAFNTAFLMVIASRLIQVREPESELIAK
                     KPVKNIKIGTFVTTREQLNETVASYLKDYQTKKMSYKFYATSSSILFEGTYQLLGYEVP
                     LYIYFQPHRLENGAVQLQVISFSVGTLPLPEKDVLQYLKSSYKLPSFVKVMPNQSAIVV
                     NLQDIQNDAKVYLKAKKIDLFNDEISFNIYKK"
     gene            complement(4039..4881)
                     /locus_tag="ETT68_RS06015"
                     /old_locus_tag="ETT68_06010"
     CDS             complement(4039..4881)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635578.1"
                     /locus_tag="ETT68_RS06015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06010"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_011888746.1"
                     /transl_table=11
                     /translation="MNNRHLFSGIFFFVISLCLAFLLLNIIIPKSNSRLKKSDFLKKEQ
                     VAIQYVAIGDSLTEGVGDLTHQGGFVPLLTNDLSEYFKANVNHQNYGVSGDTSQQILDR
                     MIKQKQIQLSLKKADIMTLTVGGNDVMAVIRKNLADLQVSSFRKPARQYQKRLRQIIEL
                     ARKDNKDLPIFILGIYNPFYLNFPELTDMQKVIDDWNIKTKEVVGEYDRVYFVPINDLL
                     YKGINGQEGIVHSSGDQTTIVNDALFTGDHFHPNNTGYQIMSNAVMEKIKKHEKKIKP"
     gene            complement(4874..5713)
                     /locus_tag="ETT68_RS06020"
                     /old_locus_tag="ETT68_06015"
     CDS             complement(4874..5713)
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264715.1"
                     /locus_tag="ETT68_RS06020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06015"
                     /product="DegV family protein"
                     /protein_id="WP_136113728.1"
                     /transl_table=11
                     /translation="MGTIKIVTDSSITIEPELIKALDITVVPLSVMIDSKLYSDNDLKE
                     EGHFLSLMKASKSLPKTSQPPVGLFAETYENLVKKGVTDIVAIHLSPALSGTIEASRQG
                     AEIAEAPVTVLDSGFTDQAMKFQVVEAAKMAKAGASLNEILAAVQAIKSKTELYIGVST
                     LENLVKGGRIGRVTGVLSSLLNVKVVMALKNDELKTLVKGRGNKTFTKWLDSYLAKNSH
                     CPIAEIAISYAGEASLALTLKERIAAYYNHSISVLETGSIIQTHTGEGAFAVMVRYE"
     gene            complement(5941..6870)
                     /locus_tag="ETT68_RS06025"
                     /old_locus_tag="ETT68_06020"
     CDS             complement(5941..6870)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285633.1"
                     /locus_tag="ETT68_RS06025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06020"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_109991713.1"
                     /transl_table=11
                     /translation="MTSKKACLSSIIVLASLTCGNDTVSANHLSATGDKFDDCSTLVEK
                     DVAPKDELEMLAWSSSQTTDDADRDYEDFLDDDSFNDDSFISQNETDKMFENLTDDRLL
                     DELDEEDTIEPEQNVIMPSDDGLFDLTDAVETRLTVSSAPHLEAELPKPHLRSLSDTAL
                     RSGEIRGHLDNKLDALSVTATKLALTMAQKFDLTTHVYSIGESFSEVLAAHYEDRKAES
                     AFSKKKRFHLPIATPDVVIEELRRLVSSIGSSKEDVSVPYNRKLGMAVAKRKIALPQTG
                     EEFSYYPALLGLMILGLTPIMIPKKINN"
     gene            complement(7042..8703)
                     /gene="recN"
                     /locus_tag="ETT68_RS06030"
                     /old_locus_tag="ETT68_06025"
     CDS             complement(7042..8703)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051804.1"
                     /locus_tag="ETT68_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06025"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_002989120.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIDEISLNFENGMTVLTGETGAGKSIIIDAMNMM
                     LGARASTEVIRRGANKAEIEGFFSVDATPELVACLESSGIAMEEELIIRRDIFANGRSV
                     SRINGQMVNLATLKQVGQFLVDIHGQHDQEELMRPQLHQQILDAFGDKAFEQLKENYQL
                     IFDRYKSLRRQVIDKQKNEKEHKDRIDMLAFQIAEIEAAALSRGEDDRLNQERDRLMNH
                     KQIADTLTNAYVMLDNDDFSSLSNIRSSMNDLLSIEQFDSEYKGMSTSISEAYYILEEV
                     SKQLSDTIDQLDFDGGRLQEIEFRLDTLNSLTRKYGGNVNDVLDYYDNIIKEYQLLTGD
                     DLSSGDLEAELKSLEKQLVAAASELSVSRHQLAEQLEAEIKAELKELYMEKADFKVHFT
                     TSKFNRDGNESLEFYISTNPGEGFKPLVKVASGGELSRLMLAIKAAISRKEDKTSIVFD
                     EVDTGVSGRVAQAIAQKIYKIGRHGQVLAISHLPQVIAIADYQYFISKESKEESTVSKV
                     RLLTPEERVEEIASMIAGTDMTQAALTQARELLAKH"
     gene            complement(8724..9194)
                     /locus_tag="ETT68_RS06035"
                     /old_locus_tag="ETT68_06030"
     CDS             complement(8724..9194)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983907.1"
                     /locus_tag="ETT68_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06030"
                     /product="arginine repressor"
                     /protein_id="WP_002983907.1"
                     /transl_table=11
                     /translation="MKKSERLELIKKMVLTHPIETQHDLLRLLAEHGLELTQATISRDM
                     NEIGIVKIPSGSGRYIYGLSQDSGKKIVQGPRSIKSTILAVSDKTKGLEQHLYLKVVPG
                     NSKLIKRYLLADFSKAIFSLIADDDSLLLIAKSPSEADMIRQEILLWMQGIT"
     gene            complement(9181..10008)
                     /locus_tag="ETT68_RS06040"
                     /old_locus_tag="ETT68_06035"
     CDS             complement(9181..10008)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017216.1"
                     /locus_tag="ETT68_RS06040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06035"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_136275630.1"
                     /transl_table=11
                     /translation="MPKERVDVLAYKQGLFETREQAKRGVMAGLVVSVINGQRYDKPGD
                     KIDDGTELKLKGEKLKYVSRGGLKLEKGLHVFGVSVANQIGIDIGASTGGFTDVMLQDG
                     AKLVYAVDVGTNQLVWKLRQDPRVRSMEQYNFRYAQPEDFNEGQPVFASIDVSFISLSL
                     ILPALHNVLSDQGQVIALIKPQFEAGREQIGKKGIVKDKQIHEKVIQKVMDFASGYGFT
                     VKGLDFSPIQGGHGNIEFLAHLVKSQTPETLAPHLIQEVVAKAHKEFEKDEKK"
     gene            complement(10001..10873)
                     /locus_tag="ETT68_RS06045"
                     /old_locus_tag="ETT68_06040"
     CDS             complement(10001..10873)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888744.1"
                     /locus_tag="ETT68_RS06045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06040"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_002992347.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.9e-51, bitscore:
                     170.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLI
                     LLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDDLPAMDNDDYRRGRLTNHKQFGEAT
                     AILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQALSL
                     PQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTAS
                     FEDLGKTPKKDLFAEKATYPSLLGLEASYQLLTESLDQALTIFQTLENDVGFKPQIITK
                     LIEGLRLNA"
     gene            complement(10873..11088)
                     /locus_tag="ETT68_RS06050"
                     /old_locus_tag="ETT68_06045"
     CDS             complement(10873..11088)
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983901.1"
                     /locus_tag="ETT68_RS06050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06045"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_002983901.1"
                     /transl_table=11
                     /translation="MSKTKTFEENLQDLETIVNKLENGDVPLEEAISEFQKGMLLSKEL
                     QKTLQAAEKTLVKVMQADGTEVDMDD"
     gene            complement(11066..12406)
                     /gene="xseA"
                     /locus_tag="ETT68_RS06055"
                     /old_locus_tag="ETT68_06050"
     CDS             complement(11066..12406)
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989115.1"
                     /locus_tag="ETT68_RS06055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06050"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_109991715.1"
                     /transl_table=11
                     /translation="MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIG
                     ALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGV
                     EILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIF
                     ESQLPVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQA
                     CLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKGNKVQ
                     LDYALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRII
                     ARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI"
     misc_feature    complement(12469..12483)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.26"
                     /tool="antismash"
     misc_feature    12476..12492
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            complement(12559..13413)
                     /locus_tag="ETT68_RS06060"
                     /old_locus_tag="ETT68_06055"
     CDS             complement(12559..13413)
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922486.1"
                     /locus_tag="ETT68_RS06060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06055"
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="WP_002989114.1"
                     /transl_table=11
                     /translation="MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPA
                     SQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHI
                     NDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVI
                     IGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKE
                     GAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRS
                     THK"
     gene            complement(13621..15315)
                     /locus_tag="ETT68_RS06065"
                     /old_locus_tag="ETT68_06060"
     CDS             complement(13621..15315)
                     /EC_number="5.4.2.-"
                     /GO_function="GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635581.1"
                     /locus_tag="ETT68_RS06065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06060"
                     /product="phospho-sugar mutase"
                     /protein_id="WP_002989112.1"
                     /transl_table=11
                     /translation="MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFG
                     TAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHGPEAVKKGIAVSYDVRYQSRTFAEL
                     TCSIMAANGIKAYLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQEGS
                     QILDDIADQIAQHMAALTQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTIND
                     TDIDKSVRVVYTPLNGVGNLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPK
                     TFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYVFLNGNKIGALLSYYIFSQRF
                     DLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLF
                     GYEESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQI
                     ALELEGIEGQKRIARIMEDFRQTPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDG
                     SWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIEAACRTKINQVN"
     misc_feature    complement(15333..15348)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.0"
                     /tool="antismash"
     misc_feature    15366..15377
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(15485..15500)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            complement(15493..16902)
                     /locus_tag="ETT68_RS06070"
                     /old_locus_tag="ETT68_06065"
     CDS             complement(15493..16902)
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989109.1"
                     /locus_tag="ETT68_RS06070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06065"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_109991716.1"
                     /transl_table=11
                     /translation="MVSVMWFRRDLRIDDQKALAHVIASQSPTLCVFQFNKEQLNLLHS
                     RNQSSFITSVLAFRKLLKCEGIDLYLMYGDLMTCFEQLLTQLKDWTDVYFNYDESGYGR
                     LRDQKAAQFFKKNGIAVHTYQDHYLHGSQEIINQSGQPYKVFTPYYRIWQNYPKETPIK
                     VELSQGRWLNLETPDDVLMTVESFKDEKYQDVATFDEASKQLNRFIQDQLAAYHANRDF
                     PAQLGTSRLSPFLRIGAIGIRTVYHAVRQAPNSLGQATFLKELAWRDFYNMVYVAYPDQ
                     KTQPIQKAFSQIEWVNNPDWFQLWKEGKTGYPIVDAAMLQLQKTGWMHNRLRMIVASFL
                     TKDLLCDWRLGEQYFQQQLIDYDAASNIGGWQWAASTGTDAVPYFRIFNPVTQGKRFDP
                     KGEFIKAYLPQLEHVPEKYLHEPWKMPKYLQESVSCIIGTDYPQPIVDHAKQREQAIAK
                     YEWAKEKAKIE"
     gene            complement(17051..17785)
                     /locus_tag="ETT68_RS06075"
                     /old_locus_tag="ETT68_06070"
     CDS             complement(17051..17785)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407690.1"
                     /locus_tag="ETT68_RS06075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06070"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_014407690.1"
                     /transl_table=11
                     /translation="MTEAIISIKDLHKYYGHNEVLKGIDLDIMPGEVVVIIGPSGSGKS
                     TLLRTMNLLEVPTKGQIRFEGIDITDKKNDIFSMREKMGMVFQQFNLFPNMTVLENITL
                     SPIKTKGMAKAEADKTALSLLDKVGLSEKAKVYPASLSGGQQQRIAIARGLAMDPDVLL
                     FDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAKEVADRVIFMDGGVIVEEG
                     SPNQLFDLTKEERTKDFLSRVL"
     gene            complement(17785..18471)
                     /locus_tag="ETT68_RS06080"
                     /old_locus_tag="ETT68_06075"
     CDS             complement(17785..18471)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018000.1"
                     /locus_tag="ETT68_RS06080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06075"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_002983887.1"
                     /transl_table=11
                     /translation="MDLSFLPKYWAYFNYGVLVTIMISVSVVFFGTLIGVLVTLIKRSH
                     VKPLTWVVNLYVWIFRGTPMVVQIMIAFAWMHFNNMPTIGFGVLDLDFSRLLPGIIIIS
                     LNSGAYISEIVRAGIEAVPKGQLEAAYSLGIRPQNAMRYVILPQAFKNILPALGNEFIT
                     IIKDSALLQTIGVMELWNGAQSVVTATYSPISPLLVAAFYYLMVTTVMAQLLAVLERHM
                     AQGGNH"
     gene            complement(18598..18828)
                     /locus_tag="ETT68_RS06085"
                     /old_locus_tag="ETT68_06080"
     CDS             complement(18598..18828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003105222.1"
                     /locus_tag="ETT68_RS06085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ETT68_06080"
                     /product="YkuJ family protein"
                     /protein_id="WP_002983885.1"
                     /transl_table=11
                     /translation="MESHLVRIINRLELMVTDGGNLKRNFERDGVVVAEVAFSNDPENG
                     PVFTLRDVEARESYSFDSIDLIAMEIYDLLY"
     misc_feature    complement(19202..19215)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.93"
                     /tool="antismash"
     misc_feature    20089..20109
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.95"
                     /tool="antismash"
ORIGIN
        1 gccatcatgg cttcagatta tgagggtcta gtggaactaa acctttcttg ccctaacgtt
       61 ccaggaaaac cacagattgc ttatgatttt gaaaccactg atcaacttct agagaacatc
      121 tttatctatt acactaaacc tcttggtatc aaattacctc cttattttga cattgtgcat
      181 tttgatcaag cggctgcgat tttcaataaa tacccccttt cctttgttaa ctgtgtcaat
      241 tctatcggaa atgggctggt cattgaggat gaacaagtcc tcatcaagcc taaaaatggc
      301 tttggtggta taggtggaga ttacatcaaa cctactgctc tagccaatgt ccatgcgttt
      361 tacaaacgct taaaaccttc tatccacatt attggtacag ggggagttaa aacaggacgc
      421 gatgcctttg aacatattct ttgtggcgcc agcatggtcc aaattgggac agcccttcat
      481 caagaagggc cagctatctt tgaacgggtc actaaggaac taaaaacgat tatggtagaa
      541 aaaggctacc aaagcttaga cgattttcgt gggaacttac gttacaaaga ttaaccttaa
      601 tagtcaaaaa agcttggaaa tgtgcacttt gtacactttc caagcttttt aaaatgggaa
      661 tttttttgaa gggacagcgt cactttcttg ggactgtctt tgctggttgt ttgattcaac
      721 ttttcttttt tgcttgcgct caaattgctg ataaaaatag aaaaatagaa tgattttaat
      781 tattgaaaat acagctaaac caatgatcat aatagtaaac atacggcggt tttctctttc
      841 ataagtctta gtattattat aaacactttc aagttttcaa gcaagtttct aaattattta
      901 aaagaaagta aacgcaagcc atttaaaatc actaaaatcg ttgagccttc gtgtccaaca
      961 acaccaagcg gcaagttaac tacctgaaaa acattggcta aaatcaataa ggtaatcaca
     1021 gataaggcaa aaacaatatt ttgtttgata atggtcttca ttttgcggga aagttgaatc
     1081 gaaaatggaa tacgagtcaa gtcatccata atcacactgt ctgcactttc cattgcaata
     1141 tctgttcctg atccaatagc ataagaaaca tctgcttgag caagggcagg agcatcatta
     1201 ataccatctc ctaccatagc cacaaaacca tatttagtct ttaattctgc taacttagcc
     1261 accttatctt gaggcataca gttggctacc acttcatcaa taccaagttt ttgtgccaca
     1321 taattggcgg ttcgttcttg gtcacctgtt aacatgactg ttttgattcc catggcatga
     1381 agagacttaa tagcacgttt tgattctatt ttgatatcat ccaagagggc atagtaagct
     1441 atcaattgat ggtcacgtga aacaaagatt agggttttcc cttgattttc ttccacttga
     1501 atcgtttctt caaaagctga taggtcttga accttttcca aaatgaaggt tttcttgcca
     1561 attcgccatt cttgcccttg atagaagccc tgaaaacctt tcccagaaat ttcttctaag
     1621 tggtcaaagg tcagtggctc caatttttca gtgtattcaa gaagggcttt agaaatagga
     1681 tgggtactag cagcctctgc tccttttacc agtctattca cgagcaactc atcttccaaa
     1741 taatgagcat tcacaacaga aggttttcct tgggtgagcg ttcccgtttt atccatgaca
     1801 acagccttaa tatctcccat gttatcgaca atatcccctc ctttgataat caatcccttt
     1861 ctggctgcac gagaaatagc agccaagcta gcaggtgtgg aactggcaat tagggcacat
     1921 ggtgaagcta ctgttaagag aatcatccct cggtaaaaag cagccaacca agtccaagaa
     1981 agcacaaagt ggctaaagag gataaaggca ggaataagga cgagcacaaa tttgacataa
     2041 ccatcttcta agctttcgat aaaggtggcg gttttgcttt tcttttcttg ggcagattcc
     2101 accagattaa taatcttggc aaagagagta tcgtcatttt caatagtaac caacatatct
     2161 atggtttgtc cttggttaat ggttccccca atcagatcct ggccttctgc cttatcaaca
     2221 gtgataggct caccagtgac catagattca tcaaattgac caaaaggact aagcaactgc
     2281 ccgtcaattg gaacagcttc gcctttacga acttgtaaac ggtcaccaac actcaaggat
     2341 ctggtctcaa cttctaaaat atggccatct tcttggtatt gacgagctgt atctggcgtc
     2401 aaggacatca agcctgaaat agcatcctta cttttttcca tggccatttc ttcaagcgta
     2461 ttggacaacg aaaagataaa aataagcaga gcaccctcca gccaatagcc gataattcca
     2521 gcaccgatag ctgccaaaat catcaaaata tccactgaca agtgtttgtt cttcaccaaa
     2581 tccaatatac ccgtttttgc agacgcatat cctccaatca agaaggctgt aatgaaaata
     2641 gcggaagcca cttgtggaaa tgagtgtaaa aaggctaggc caattattat taataccaaa
     2701 cacgctaaag tctccattaa atgaagatgg tctgccatcc attgtctgat tgtcattttt
     2761 agttccctcg caattaaaag ttattcaatc tttaagatat attaattata ataattctaa
     2821 ataaataagt caagtaattt agaaacattc taaataaact tttttaaact taccttttgc
     2881 tttcaaaaat cctaacttca actatttgca aatatgaaaa aaactccccc tacttgcgga
     2941 aatgatatac taatagaagg atgactgacc attatagagt gcatgcatta gaacttggct
     3001 taactgaaga gaaaactact aactttatgc cccaaatata aaaaaagaac cttgtcgcta
     3061 tcaataaaca tcgatagcaa caagattttt ctagacgaat tatttaacag cgtctttaag
     3121 agctttacca gctttgaagg ctggaacttt tgaagctgca atttcaattt ctgcaccagt
     3181 ttgtgggtta cgacctttac gagctgcacg ttcgcgtact tcgaagttac caaaaccgat
     3241 caattgtact ttttcacctt cagcaaggaa agcttcgatt gtagaaaaca cggcatcaac
     3301 tgctgctgct gaatcttttt tagtcaattc agttgcttct gcaacctttg cgattaaatc
     3361 ttgtttgtta gccatttaac aaatcctcca aataattagt aagcttaatg ctttaacaga
     3421 tattatcata tctaaaaaaa gcgattaggt caagtattta acgttatttg aggttatttc
     3481 ttatagatgt taaaactgat ttcatcatta aataaatcaa ttttcttggc ttttaaataa
     3541 accttagcat cattttggat atcttgtaaa ttaacaacga tagctgattg atttggcatc
     3601 actttaacaa agcttggcaa tttgtagctt gatttcaaat actgcaaaac atctttttct
     3661 gggagtggca gagttcccac tgaaaaagag atcacctgta gttggacagc tccattttct
     3721 agacgatgag gttgaaaata gatatataaa gggacttcat accctaataa ttgataagtt
     3781 ccttcaaaca aaatagaaga agatgtcgca taaaatttat aagacatttt tttagtctga
     3841 taatctttaa gataacttgc tacagtttcg ttaagctgtt ctctggttgt gacaaatgta
     3901 ccaattttga tatttttaac tggtttttta gcaatcagtt ctgactcagg ttctcttact
     3961 tgaatgagac gacttgcaat aaccatcaaa aaggcggtat taaaagcaag cagacataag
     4021 aagctccact tccaccaatt aaggtttgat ttttttttca tgctttttaa ttttctccat
     4081 tactgcattt gacatgattt gatagccagt attatttggg tgaaaatggt ccccagtaaa
     4141 caaggcatca ttgacaattg tagtttgatc tcctgaagaa tggacaattc cttcttgtcc
     4201 atttatccct ttatacaaga ggtcatttat tggcacaaag tacacacgat cgtattctcc
     4261 aacaacctcc ttagttttga tattccagtc atcaatcact ttttgcatat cagttagttc
     4321 tggaaaattc aaataaaacg gattatagat gcctaaaata aaaataggaa gatctttatt
     4381 atcttttctg gctaactcga taatctgtct taatcgtttt tgatactgac gagctggctt
     4441 tctaaaacta gaaacttgca aatccgctaa attcttccga ataactgcca taacatcatt
     4501 accaccaacg gttaacgtca ttatatctgc tttttttaaa gataactgta tctgcttttg
     4561 ttttatcatc ctatcaagaa tctgttgact ggtatcacca gatacgccgt aattttgatg
     4621 attaacatta gccttaaaat attcactgag atcattcgtt aacaaaggaa caaaaccacc
     4681 ttgatgagtt agatcaccta ctccttctgt caatgaatct cctatagcaa catattggat
     4741 agctacttgt tcttttttca gaaaatcact ctttttcaaa cgtgaatttg acttagggat
     4801 aataatattt agcaataaaa aggccagaca taaactaata acaaagaaaa atattccact
     4861 aaataaatga cgattattca taacgaacca taaccgcaaa agctccttct cctgtatgtg
     4921 tttggatgat agagcctgtt tctaaaaccg aaatagagtg gttgtaataa gctgcgattc
     4981 tttcttttaa ggttaatgcc aggctagctt caccagcata agaaatagct atctctgcaa
     5041 tcgggcaatg actattttta gcgaggtaac tatctaacca tttcgtaaat gttttattac
     5101 ctcgaccttt gacaagcgtt tttaactcat catttttaag tgccataaca actttgacat
     5161 taagtagcga gctcaaaaca cccgtcacac gaccaatacg acctcctttt actaaatttt
     5221 ctaaggtaga tacaccaatg tagagctctg tttttgattt gatagcttga acagcagcca
     5281 aaatctcatt caaactagca cccgcttttg ccatctttgc tgcctcaacg acctgaaatt
     5341 tcatggcttg atcagtaaat cctgaatcta aaactgtaac aggtgcctca gcgatttcag
     5401 ccccctgacg ggaagcttca atagtacctg ataaagctgg tgagaggtga atagcaacaa
     5461 tgtcagttac tccttttttg accaaatttt cgtaagtttc agcaaagaga ccaaccggtg
     5521 gctgactggt tttgggaagg gatttgctag ccttcataag actcaaaaaa tgaccttctt
     5581 cttttaaatc attatcagaa tataatttgc tatcaatcat gacagataaa ggcactacag
     5641 taatatctaa agctttaatt aattctggtt caatagttat tgatgaatct gtaacaattt
     5701 ttatagttcc catgtatttt tccattctaa actagtttct cacctcttta ttctaacact
     5761 ccttgctaaa taaagcaaaa ctggtagtgc tattgaataa tcactcggta gataggtatg
     5821 gcgagcacta gctgctcgaa gaaaatgcct tagcaataac gagatacaaa acgaggcaaa
     5881 agtcaacctt ttcacgcttg aacatttgcc ccgtctttta caactacaat aacttattac
     5941 ctaattattt atcttctttg gtatcataat cggcgttaat cctaatatca ttaaaccaag
     6001 taaagctgga taataagaga actcctctcc cgtttgtggc agggctattt ttctttttgc
     6061 aactgccata cctagcttcc gattataagg aactgaaaca tcttcttttg aacttccaat
     6121 agaagagact aggcgcctta actcctctat aacaacatct ggagtagcaa taggaaggtg
     6181 aaatctcttt ttcttagaaa aagctgattc tgcttttctg tcttcataat gagcagctaa
     6241 tacttcacta aagctttcac ctatagaata gacatgcgtt gtcaaatcaa atttttgagc
     6301 catcgttaat gctaactttg tagctgttac agacaaagcg tccagtttgt tatctaaatg
     6361 tcctctaatt tcaccagacc gcagtgctgt atctgatagg ctcctcaaat gtggtttcgg
     6421 caattcagcc tctaaatggg gagcactaga aacagtaagg cgtgtctcaa cagcatcagt
     6481 taaatcaaat agcccatcgt cactaggcat tattacattt tgctctggct caattgtatc
     6541 ttcttcatct aattcatcta ataacctatc atcagttaaa ttctcaaaca tcttatcagt
     6601 ttcattttga gaaataaaag aatcatcatt aaaagaatca tcatcgagaa aatcttcata
     6661 gtctctgtca gcatcatcag ttgtttgaga cgaggaccat gctaacatct caagttcatc
     6721 tttaggggcc acatcttttt caacaagtgt tgagcaatca tcaaacttat ctccagttgc
     6781 tgagagatga ttggcactaa cagtatcatt tccacacgtt aaacttgcta acacaatgat
     6841 gcttgataaa cacgcttttt tactagtcat ttctatcccc tcagcttaaa attctcttat
     6901 ctattctact atttctcaga ggtttgtcaa ggcaaaccaa gccagattaa cagaggaaaa
     6961 atggtctaac acaatgatta ttttagcacc taaaaaatca atttcatcta attatgaaaa
     7021 tatcaaatac caaacataat cttaatgttt ggcaagtagt tcacgagcct gcgtaagagc
     7081 agcttgtgtc atatctgttc ctgcaatcat gctagcaatt tcttccacac gttcttcagg
     7141 agttaataac cttaccttag aaacggtgga ctcttcttta ctttctttag aaataaaata
     7201 ctgataatca gcaatagcaa taacttgagg taagtgtgaa atagcgagaa cttgcccatg
     7261 tcgcccaatt ttataaattt tttgggcaat ggcttgcgca acgcgaccag aaacacctgt
     7321 atctacttca tcaaaaacaa tactcgtctt atcttctttt ctagaaatag cagccttgat
     7381 ggctaacata aggcgtgata actctcctcc agaagccacc ttgacaaggg gcttgaatcc
     7441 ttcgcctgga ttagtagaga tgtaaaattc caagctttca ttaccatcac gattgaattt
     7501 tgatgtggta aagtgaactt tgaaatctgc tttttccata taaagttcct taagttcagc
     7561 tttaatctca gcttctaatt gctccgccaa ttgatggcga gagacactta actccgaagc
     7621 agcagcaacc aattgttttt ccaagctttt caattctgcc tctagatccc ctgaagacaa
     7681 gtcatctcct gttaatagct ggtattcttt gataatatta tcgtagtagt caagcacatc
     7741 attcacatta ccaccgtatt tacgggttaa gctattgagt gtatccaagc gaaattcaat
     7801 ttcctgtaat cgcccaccat caaaatccag ttggtcaatg gtatctgata attgcttgct
     7861 cacttcttca agaatataat aggcttcaga aatcgaagtc gacatccctt tgtactctga
     7921 atcaaactgc tcaattgata gtaagtcatt catgctagag cgaatattgg atagacttga
     7981 aaaatcgtca ttatctagca tgacgtaggc attggtcagg gtatcagcaa tttgtttgtg
     8041 gttcattaag cgatcacgtt cttgatttaa ccggtcgtcc tcacctcgac tcaaggcagc
     8101 agcttcaatt tctgctatct gaaaggccaa catatcaata cgatctttgt gttccttttc
     8161 atttttttgt ttgtcaataa cctggcgacg caagctttta taacgatcaa aaataagctg
     8221 atagttctct ttcaattgct caaaagcctt atcaccaaaa gcgtccaaaa tttgctggtg
     8281 gagctgtggt cgcattaatt cttcttggtc atgttgccca tgaatatcta ccaaaaactg
     8341 tccgacctgt tttaaggtgg ctaggttaac catctgacca ttaatgcggc tcacgcttct
     8401 gccattggca aagatatccc ggcgaataat cagttcttct tccatagcaa tacctgatga
     8461 ttccagacac gcaaccagtt ctggggtagc atctaccgaa aagaacccct caatttctgc
     8521 tttattagct ccacgacgaa tcacttctgt actagcacgc gcaccaagca tcatattcat
     8581 agcatcaatg ataatagact ttcctgctcc agtttcaccc gtcaaaaccg tcataccatt
     8641 ttcaaaattt agggaaattt catcaataat agcaaaattt ttaatggaaa tttctaataa
     8701 catcactttc tcccctattt tttctaggtt ataccctgca tccaaagcaa aatttcttgg
     8761 cgtatcatat ctgcttctga aggagacttt gcaattaaca gtaaactatc atcatcagca
     8821 ataagactaa aaatagcttt tgaaaaatct gctaataaat aacgtttgat taatttacta
     8881 ttgccaggta cgacttttaa atagaggtgt tgttctaaac cttttgtttt gtcagataca
     8941 gctaaaatag tgctctttat cgatctaggt ccttgaacga tcttttttcc actatcttga
     9001 gaaagaccat agatgtaacg tccactgcca gaaggaatct ttactatacc aatttcattc
     9061 atgtctcttg aaatagtagc ctgggttaat tctaacccat gctctgccaa taatcttaag
     9121 aggtcatgtt gcgtctcaat tggatgcgtc aaaaccattt ttttgattaa ttcaagtcgt
     9181 tcactttttt tcatctttct caaactcctt atgtgccttg gcaacaactt cctgaatcag
     9241 atgtggggct aacgtttcag gtgtctgtga cttaacaaga tgagctaaaa attcgatatt
     9301 tccatgacca ccctgaatag gggaaaaatc aagtccctta actgtaaatc cgtaacctga
     9361 ggcaaaatcc atgacctttt gaatcacttt ttcatgaatc tgtttgtctt tgacgatgcc
     9421 ttttttacca atctgctcgc gcccagcttc aaattgcggt ttaatgagag caataacctg
     9481 tccctgatct gacaaaacgt tatgcagggc tggcaaaatc aagctgagag aaataaagga
     9541 cacatcaata ctggcaaata caggctgtcc ctcattaaag tcttctggct gagcataacg
     9601 aaagttatac tgttccatac ttcttactcg tggatcttgt ctgagtttcc ataccaactg
     9661 gttagtccca acgtcgacgg catagactag tttggcccca tcttgtaaca taacatcggt
     9721 aaaaccacct gttgaagcgc caatatcaat cccaatttga ttagcaactg atacaccaaa
     9781 aacgtgcagc cccttttcca gttttaatcc accacgactg acgtatttga gtttttcacc
     9841 tttaagtttt aactcagtcc catcgtcaat tttgtcacct ggcttgtcat agcgttggcc
     9901 attaatcaca gagaccacta ggcctgccat aacaccacgc ttagcttgct ctctggtctc
     9961 aaataatcct tgcttatagg ctaacacatc tactctttct ttaggcatta agtcgtaacc
    10021 cttctatcag ttttgtaatt atttgaggct taaagcctac atcgttttct agtgtctgaa
    10081 aaatcgtcaa agcctgatct aaactctctg tcaacagttg gtaggaggct tctaacccca
    10141 gtaaacttgg gtaagtagct ttttctgcaa ataaatcctt tttaggcgtt tttccaagat
    10201 cttcaaagct agctgtcacg tctaaaatat catccctaat ctgaaaggcg tgcccgatga
    10261 gcattcccgc ctgctctagt tgttgacgaa cagtaatagc ctgttctgtt acaagagctg
    10321 ctgctttaaa aggaaaagtt aataattttc cggttttatt gaggtgaatc agtgacaact
    10381 gagggagact caaagcttga ttttcccctt tcatatctag catctgacca ccaaccatgc
    10441 caaaagttcc tgaagctagg gaaagttctt ggattaaggc tactttaacc tcgctattta
    10501 attcagcttg agctattaac ccaaaggggt ctaaaaataa gctatctccc gccaaaatgg
    10561 ccgtggcttc tccaaattgt ttgtgattgg tcagtctacc acgtcggtaa tcatcattat
    10621 ccatggctgg caaatcatcg tgaatcagac ttcctgtatg aatcatttca agggctgcag
    10681 ccaaatcaaa atgagcattc tgtaacgata ccccaaatcc ctcaatcatc tctaataaga
    10741 taagtggtcg aatgcgcttg ccaccactgt caacagaata caagatagca tcaatcaact
    10801 cttcagatac accgttacta gtcgtcttat agtagcgacg aatggcttcg tcaattctag
    10861 ctaatttgtc cattaatcat ccatatctac ttctgtgcca tcagcttgca tcactttgac
    10921 gagtgttttt tctgccgctt gtaaggtctt ttgaagttct tttgagagaa gcattccttt
    10981 ttgaaattct gaaatagctt cttccaaagg gacatcccca ttttcaagtt tgttcacaat
    11041 agtctctaaa tcttgtaaat tttcttcaaa tgttttcgtt tttgacatct tttacctcta
    11101 catctaattg tccatcacgc atcttaatgg ttaactgatc accctttgtt atctgactta
    11161 cagaggctac cagtgcttga tttttttcaa tcattgcata accacgggcg ataattcggc
    11221 tggcatccag tgatagcaaa gcatcctgtg ctttttcaaa gcgagccagc tgactatcat
    11281 attgactagc catattagcc atcagtaaac gcttagcggt agcaacacgg tcttggtatc
    11341 gctcgatttt tgtctgtaat tgactattgg ccaaggcata gtccaactga accttgtttc
    11401 ctttggcgga actcagacga tctttcatcg tattcatcag ggtcatgcta aggcgatcaa
    11461 ttttttgcag gtaggcatca tataatcgtt ctggttgcct aaaaataaca gattgcgaga
    11521 gtttatccac ccactcttgc cgttgcttaa tccgcctcaa gcaggcctga taggaacgat
    11581 tttgccgctc tactatccaa gacataagat ctgtttttgt aataggcgtt gctaactctg
    11641 ctgctgctgt tggtgtggct gctctgcgat ctgccacaaa atccgctaaa gtcgtgtctg
    11701 tttcatgacc cacactcgaa atcactggaa gttgcgattc aaagatagcc tgaaccacta
    11761 tttcctcgtt gaaggcccaa aggtcttcta tcgagccacc tccacggccg acaatgagca
    11821 agtccaaatc ctctctttga ttggctcttc gaatattagc cactacttct tgggcggctc
    11881 catcaccttg tactttagtc gggaataata aaatctcaac ccctggaaaa cgccgtgaaa
    11941 cggttgtgat aatatctcga atcacagcac cactaggact tgtaatgacc ccaatttttg
    12001 atacaaactg tggcaaaggc tgcttgtgtt tttgctcaaa ataaccttct gccgttaatt
    12061 ttttctttaa ttgttcaaac tgcaaagcca aggcacctat accatctggc tctgcctttt
    12121 caatcacgat agagtaagag ccactaggtt cataaagttg aactcgccca attacattaa
    12181 ttttcatgcc ttcttctagg tcgaatccta gttttttata gactcctgcc cacatggtgg
    12241 cttgaatcac agcactttca tcctttaagg aaaaatattg atgagttggt cgttttcgaa
    12301 aattggacac ttgaccagtc agataaaccc gttccaaata agggtcacgg tcaaatttta
    12361 attttaaata tttcgtcaaa tgagtgacgg ttaaataatc tgccatcaag ccacctttca
    12421 cttagttgga cctgacatag tccctttgca tactaatgca attataccat ttttctgaat
    12481 aaatagtgag cagaaaaaca aaaaaggaag ccattgctga cttcttatat tctcttatgt
    12541 tgaattgtct aatgataact atttatgagt actacggaga gcagattgat aagtttgctc
    12601 tagcaacata gcaatcgtca taggaccgac acctcctggt acaggggtga ttttcgctgc
    12661 aacttctgcc acctcatcaa aggccacatc tccaattagc ttgccattat catcacggtt
    12721 cattcccaca tcaatcacta tcgcaccctc ttttatatat tgttttgtta tgaaatgacc
    12781 ttgtccgatt gccacaatca acacatctgc acagcgacat acttcttcta attgacgtgt
    12841 tcttgaatgt gtcaacgtga ctgttgcatt tttgtccagt aagagctgtg ccattggttt
    12901 tccaacgata ttcgatctgc caataatgac ggcatgttta ccttcaaggt taacattata
    12961 ttctcgaagc aattccataa tccctgatgg agtacaagga accatcaagg gacgtcctga
    13021 ccaaaggtga cctgtattca tcgggtgaaa accatccaca tcttttttgg gatcaatggc
    13081 gagaataatt tttttatcat taatatgatt tggcaggggt agctgcacta aaataccatg
    13141 aatagtgtta tctgcattgt aacgttcgat tactgcaata agctcttctt gacaaatgaa
    13201 ttctgataat ctaacggtct cacttttaaa acctacagta agagctgcac gctctttatt
    13261 acggacatac acctgactag caggatcatc acctacaaga ataacggcta agcctggtac
    13321 aattcctttt ttttgtttta gattgttgac tttagctgct aactcttgtt gcatcttttg
    13381 agctaaggct ttaccatcaa ttagttctgt cattgacatc tccctttaat ttcatttttc
    13441 tattataaca aaaaaataga tgcctgttct ttatactctt acttattttt tagtattggt
    13501 ttgagtcgat taaattgatt agtggcacct acaagaaaaa gaaggtgcct aaaagtctca
    13561 cctccttttg tagttgttta tatggaaaaa tagtgtaaaa gtgttatcca tttttgatgt
    13621 ttaattaacc tgatttattt ttgtgcgaca cgctgcttca atagcatcta attttgttgc
    13681 actattttct tgtgtttggc caatagtata taaataaaat tttattttag gctctgttcc
    13741 tgatggtcta agtgcatacc aagaaccatc atccaaataa aatttgagac agttttgctt
    13801 tggaaaatct tgatagccat caataaaatc aattgtcttg tctaacgcca tctctgcaac
    13861 actagctatt ggtgtctgtc tgaaatcttc cattatcctc gcaatgcgtt tttgtccttc
    13921 tatcccctca agctccaagg caatttgacg ttcattataa tacccaaatg tcgcataaat
    13981 agtctgcaaa acatctagta aattctgccc ctttttcttg tagtaagctg ccatttctac
    14041 aatcatcata gaggcgctaa cagcgtcttt gtcacgaaca aaagtgccat agcaaaaacc
    14101 aatactttct tcataaccaa acaggtagtt tttctgtttc gtcacatcat attcgtttgc
    14161 cttgccacaa atattcttaa aaccagtcaa tgtttcaacg gtttcaatac cataatggct
    14221 agcaatagcc cgtgacaagt ctcctgttac aatggatttc actaaaacag gattagccgg
    14281 taaattgcct aagtcaaatc gttgcgaaaa gatatagtaa gataaaagcg ctccgatttt
    14341 attgccattg agaaaaacat agtcaccgac tgcattttta acttctaaag ccacacggtc
    14401 acaatctgga tcagttgcaa tcaaaatatc agcatcaact gccttaccta atttttctga
    14461 atatgcaaaa gttttaggga cttcgggatt aggatagcca actgttgtaa aatcaggatc
    14521 gggcatttcc tgctcaggta ccacataaac attttcaaaa ccgcggcgtc ttaaaacctc
    14581 acgcactggt agattcccaa caccatttaa aggggtatag actactcgga ctgacttatc
    14641 aatgtcagta tcattaatcg ttaaaccaag cacttctttt ttatatgctt cttcaatact
    14701 ctcatcaata taagtaacaa gtccactgtc cagagccttt tcaaaaggca tttgtttgat
    14761 ttcctgatac tgagttagtg cagccatgtg ttgtgcaatt tgatccgcaa tgtcatccaa
    14821 aatttgagaa ccttcttgcc aataagcttt ataaccattg taagcttggg gattgtgact
    14881 agctgtaatc ataacaccag agatacatcc caaagcacga atagcgtacg aacacattgg
    14941 tgttggccga atccctttat aaaggtacgc cttaataccg ttagctgcca taatagagca
    15001 tgttaattct gcaaatgttc tagattgata gcgaacatca taactaaccg caatgccctt
    15061 tttaaccgct tcaggtccat gatcaataat agtattagct aaagcttgtg ctgccttacc
    15121 aaccatatag gtattcatgc gattggtgcc tgctccaagt tttcctctta gccctgctgt
    15181 tccaaattca agtgttttgt aaaaacgatc ttgaatctca gcctcattgt cttttatggc
    15241 tgctaaatct gctttaatat catcactaag atcattattg tgcaaccatt cttgatatac
    15301 ctcgttgtaa gtcatattac tcatcctatt ctaagaccaa atggtaaaaa tcagctccaa
    15361 aacaagaaat cgctttctct aagggagaca actgaatagt atcaaataat ctaaataaag
    15421 tcaacttatt ttttaaatta aataatctta attcatgata actttttgtt taaactctta
    15481 taatgagaac agtcattcta tttttgcttt ttcttttgcc cactcatact ttgcaatagc
    15541 ttgttcacgt tgtttagcat gatcgacaat tggttgagga tagtctgtgc caataataca
    15601 ggatacactc tcttgaaggt attttggcat cttccacggt tcgtggagat acttctctgg
    15661 aacgtgttct agttgaggca aatacgcttt aataaactcg cctttgggat caaaacgctt
    15721 accttgagta acaggattaa atattctaaa ataaggaaca gcatctgttc cagtggaagc
    15781 agcccactgc catcctccga tattactggc agcatcataa tcaattagtt gttgttgaaa
    15841 atactgctct cctaaacgcc aatcacataa aagatcttta gttaaaaaag aagctactat
    15901 cattcgtaaa cgattatgca tccatcctgt cttttgtaac tgaagcatgg cagcatcgac
    15961 aatagggtaa cccgttttac cttctttcca caactgaaac cagtcaggat tattaaccca
    16021 ttcgatttga gaaaaggctt tttggatagg ctgagttttc tgatcaggat aagccacata
    16081 gaccatattg taaaagtctc tccaagctaa ttcttttaaa aaagtagctt gccctagact
    16141 atttggtgct tgacgcacag cgtgatatac cgtgcgaatg ccaatagctc ctattcttaa
    16201 aaaaggagat aaccgactcg tccctagctg cgctggaaaa tctcgattag cgtgataagc
    16261 tgctaattgg tcttgaataa atcgatttag ttgttttgac gcttcatcaa aagttgcaac
    16321 atcctgatat ttttcatctt taaagctctc aacagtcatt aaaacatcat ctggtgtctc
    16381 aagatttaac cacctgcctt gcgatagttc tactttaata ggagtctctt tcggataatt
    16441 ttgccaaatc ctatagtagg gcgtaaaaac tttataaggc tgacctgatt ggttaatgat
    16501 ctcttgacta ccatgtaaat agtgatcttg gtaggtatga acggcaatcc catttttttt
    16561 gaaaaattgt gctgcttttt gatcacgtaa acgaccatat ccagattcat catagttaaa
    16621 atacacatct gtccagtctt ttaattgtgt caataattgc tcaaaacagg tcattaagtc
    16681 tccatacatt agatataagt caataccttc acattttaat aactttctaa aagccaaaac
    16741 gctagtaata aaactagatt gattccgact atgtagcaga tttaattgct ccttgttaaa
    16801 ttgaaacaca cataaggttg gtgattgact agcaataaca tgagctaaag ctttttgatc
    16861 atcaatcctt aaatctctac gaaaccacat cactgaaacc ataacagatc cctttcttct
    16921 atgcaaataa tgtaactatt tctttttatt ttaacaaaaa gaaaagtaat ctcctataaa
    16981 atgccttagc aaattataaa aggaagtcct aaatcattta ggacttcctt ttataattca
    17041 tagaacagat ttataatact ctactcaaaa aatcttttgt acgttcttct ttagtcagat
    17101 caaaaagttg gttaggactt ccttcttcca caataacgcc gccatccata aaaatcacac
    17161 gatctgcgac ttctttagca aagcccattt catgagtcac aataaccata gtcatcccag
    17221 atttagccaa atcttgcatg acagccaaga cctcacccac catttctggg tctagagctg
    17281 aagttggttc atcaaagagt aaaacatctg gatccatagc cagtccacgc gcaatcgcaa
    17341 tccgctgctg ttgcccacca gaaagactag caggataaac cttggctttt tctgataatc
    17401 caactttgtc caacaagctc aaggctgttt tgtcagcctc tgctttagcc attcccttag
    17461 ttttgattgg cgataaagtg atattttcta aaacagtcat attgggaaag aggttaaact
    17521 gctgaaaaac catccccatt ttttcacgca tgctgaaaat atcgttcttc ttatcggtaa
    17581 tatcaatccc ctcaaaccta atctgtccct tagttggtac ttccaaaaga ttcatggttc
    17641 gaagtaaggt cgattttcca gaaccagaag ggccaataat caccacaacc tctcctggca
    17701 taatgtctaa atcaattccc ttaagcactt cattgtgccc ataatacttg tgcaagtctt
    17761 taattgaaat aatagcctca gtcatcaatg attacctcct tgcgccatgt gacgttctaa
    17821 gactgccaat aactgtgcca tcactgttgt gaccattaag tagtaaaaag cagccaccag
    17881 taaaggggaa attggagaat aagtagccgt taccactgat tgggcaccat tccaaagttc
    17941 catcactcca atggtttgta aaagagcact atccttaata atggtaataa attcatttcc
    18001 taaggctggc aaaatatttt taaaggcctg aggcaaaatc acataacgca tggcattttg
    18061 aggacgaata cctagtgaat aagctgcttc taattgccct tttggtacag cctcaatacc
    18121 tgctctaaca atttctgaaa tataagcacc gctattcaat gaaatgataa taattccagg
    18181 aagtagtctt gaaaagtcca agtctaaaac cccaaaacca atagtaggca tattgttaaa
    18241 atgcatccaa gcaaaggcaa tcatgatttg aaccaccata ggtgttcccc gaaagatcca
    18301 aacgtaaaga ttaacgaccc aggtcaacgg cttcacatga ctacgcttaa tcagggttac
    18361 caagacacca ataagggttc caaaaaagac aacgctgact gaaatcataa tggtgacaag
    18421 tacaccgtag ttaaagtagg cccagtattt gggcaaaaat gacaaatcca tttatatctc
    18481 ctcataagtc ctaggttcat tacaataaag ataattatac catctgatga atattaatac
    18541 aatacttttt gacaataaaa aaacctgcct caggcaagtc tctttactat gtcaagctta
    18601 atataataaa tcgtagattt ccattgcaat caagtcaatg ctatcaaagg aatatgactc
    18661 acgcgcttca acatcacgca atgtgaaaac aggtccattt tcaggatcat ttgaaaaggc
    18721 aacttctgca acaacaacac catcgcgttc aaaatttcgc ttgagattac cgccatctgt
    18781 caccatcaac tccaaacgat tgatgattct caccaaatgt gattccattt cgtttctcct
    18841 attcgttttt tatccctctt attttaacac aaaacaaggg aaactaacaa ggaaagtaat
    18901 atatttattg atattttact ttttttactc ttttcaatga ttttaaacat ttgctcattg
    18961 gaaacttaat aaagttactc tgtcatgtta ctctctaaaa gctaacgcta aagcgataaa
    19021 ctttttactt gatttcccaa gacgtggtgc tataatatga atataaagtt tgaccatttt
    19081 tgactaaatg actttgactt ttagataaac cctcggaggt atattatgct gtgtcaaaat
    19141 tgtaatttaa acgaatctac tattcatctt tatacaagtg ttaatggaaa acaaagacag
    19201 gttgatctct gtcaaaattg ttatcaaatc atgaaatccg atcctgccaa ttctatttta
    19261 aatggcctaa ccccaggata tagagcacaa gatagatcca caagtccttt ctttgatgac
    19321 ttttttggtg atttgaataa ttttagagct tttggtaatc ttccaaatac cccacctact
    19381 caggcagggc aaaatggaaa tggcggagga cgctatggtg gtaactacaa cggacaacga
    19441 cctgctcagc cacaaacacc aaatcagcaa gcaaagggct tgttagaaga gtttgggatt
    19501 aatgtcacag atattgcaag aaatggtaat attgatcctg ttattggtcg tgacgaagag
    19561 attacacgcg ttatcgagat cctcaaccgc cgtactaaaa ataatcctgt gctaattggt
    19621 gagcctggag ttggtaaaac tgctgttgta gaaggtttgg ctcaaaaaat tattgatggt
    19681 actgttcctc aaaaactcca aggcaagcaa gtgattcgtc ttgatgtggt tagcctcgtt
    19741 cagggaacag gtatccgtgg tcagtttgaa gagcgcatgc aaaaattaat ggaagaaatt
    19801 cgcaatcgca aggatgtgat tctctttatt gatgaaattc atgagattgt cggtgctggt
    19861 tctgcaggag acggcaatat ggatgctggt aatattttaa aaccagcctt ggcccgcggt
    19921 gaattgcagt tggtcggcgc taccacctta aatgaatacc gtattattga aaaagacgct
    19981 gccttagaac gacgtatgca acccgttaaa gttgatgaac cttctgttga ggaaaccatc
    20041 acgattttaa aaggtatcca accgaaatac gaagactatc atcatgtcaa atatagccca
    20101 gccgctattg aagctgctgc tcatttatct aaccgctata ttcaagaccg ttttcttcct
    20161 gataaggcta ttgaccttct ggacgaagct ggttccaaaa tgaatctaac cctcaacttt
    20221 gttgatccta aagaaattga caaacgtctt attgaagctg agaatctcaa ggcgcaagct
    20281 actcgagacg aagactatga acgcgcagct tatttccgcg atcaaattac aaaatacaaa
    20341 gaaatgcagg ctcaaaaagt cgatgagcaa gatattccca tcattactga aaaaaccatt
    20401 gaagctattg tagagcaaaa aactaatatt ccagttgggg acttaaaaga aaaggaacag
    20461 tctcaactcg taaacttagc caatgatctg aaagcacacg tgatcgggca agacgatgct
    20521 gttgataaaa tcgctaaggc tattcgtcgt aaccgtgtgg gattaggaac tccaaatcgc
    20581 cctattggtt ctttcctatt cgttggaccg actggggttg gtaaaactga attgtctaaa
    20641 caactagcca ttgaactctt tggttcgaca aacaatatga ttcgctttga catgtccgaa
    20701 tacatggaaa aacacgctgt cgccaaatta gtcggggctc ctccaggtta tgtcggctat
    20761 gaagaagctg gacagctaac cgaacaagtt cgtcgcaatc cttattccct tattctctta
    20821 gatgaggtgg aaaaagccca tcctgacgtc atgcacatgt tcttacaagt tct
//
