LOCUS       NZ_SWMS01000027        15974 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Prauserella endophytica strain CGMCC 4.7182 Scaffold27, whole genome
            shotgun sequence.
ACCESSION   NZ_SWMS01000027
VERSION     NZ_SWMS01000027.1
KEYWORDS    WGS; RefSeq.
SOURCE      Prauserella endophytica
  ORGANISM  Prauserella endophytica
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Prauserella; Prauserella
            coralliicola group.
REFERENCE   1  (bases 1 to 92297)
  AUTHORS   Liu,J.M., Habden,X., Guo,L., Tuo,L., Jiang,Z.K., Liu,S.W., Liu,X.F.,
            Chen,L., Li,R.F., Zhang,Y.Q. and Sun,C.H.
  TITLE     Prauserella endophytica sp. nov., an endophytic actinobacterium
            isolated from Tamarix taklamakanensis
  JOURNAL   Antonie Van Leeuwenhoek 107 (6), 1401-1409 (2015)
   PUBMED   25832628
REFERENCE   2  (bases 1 to 92297)
  AUTHORS   Li,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-2019) Yunnan Institute of Microbiology, Yunnan
            University, No. 2 Cuihu North Rd, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 10.16x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005146945.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:32:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,852
            CDSs (total)                      :: 7,795
            Genes (coding)                    :: 7,703
            CDSs (with protein)               :: 7,703
            Genes (RNA)                       :: 57
            rRNAs                             :: 1, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 34 of 92
            Pseudo Genes (incomplete)         :: 69 of 92
            Pseudo Genes (internal stop)      :: 2 of 92
            Pseudo Genes (multiple problems)  :: 13 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:09:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 15974
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SWMS01000027.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15974
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..15974
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15974
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[<0:5974](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..5974)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(<1..1628)
                     /locus_tag="FCN18_RS31930"
                     /old_locus_tag="FCN18_31925"
     CDS             complement(<1..1628)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="FCN18_RS31930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31925"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_137096818.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.9e-34, bitscore:
                     111.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 4.2e-45, bitscore: 146.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDSRWHHYLVEFANPATAEHTAATLLAPALDQAQQDGELDRWW
                     HLRKTPAWRLRYQPVNPDTTVVDTLLAELEADGQVARWTRGIYEPETVAFGGPAGMDIA
                     HTLFHHDSRHCLARACEAAPVALGQRETTVLLFSAMLRAAGLDWFEQGDVWAKVAALRP
                     AAHGHHTDSQRTERWNQAVRRLMTTDTHRISDVAPDQVPETWCAAFDTAGSQLATLARE
                     GQLDRGLRAILAHHFIFHANRAGLSGPDQATLVALAVDAVFHSTPTRQAPAGTTSNTVR
                     VPTMTTTVSDASTDSADELRAQLTERLIKDGTIRTDAVEAAFRQVPRHLFLPGLPLTEA
                     YADEPVYTKHEGDGTRISAASQPKIVAMMLEQLGIQPGERLLELGAATGYNASLMATLT
                     GPTGHVTTIDIDEDLVAGAREHLAAASISNVEAVAADGALGHPENAPFDRVIATVGAHE
                     IPTAWLDQLAPSGRLVAPVRLRGCASRSIVFERDQDGWSSLSSEMAIFMPLRGLGDDAR
                     RVRPCHDNCVSRGWTKIGLPDAIQKG"
     gene            complement(1656..2903)
                     /locus_tag="FCN18_RS31935"
                     /old_locus_tag="FCN18_31930"
     CDS             complement(1656..2903)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156857.1"
                     /locus_tag="FCN18_RS31935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31930"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_137096819.1"
                     /sec_met_domain="LANC_like (E-value: 9.1e-47, bitscore:
                     152.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNADLAADTTVAFAVEIADRLALPDDADLPTDQPWWHQSLAHGAP
                     GVALLHIELAAAGIRPFDRAHEWLTVVAGKPVTAGASTGGFYGAPAVARAIAGAAAVRP
                     GTYRSALAPLARQVAADAHARVDTAHRRMDAGELPVMAEFDTIRGLAGLGAYLLHHDHG
                     GTALRAVLGALVRLAHPVTIEGEALPGWWTLTGPTGRVEDEFPGGHGNFGLAHGISGPL
                     ALLAQALRRGITVDGQREAVETICAWLDSWRIDAPGGHRWPYMITREEARSRPAHVQHS
                     GADRRPSWCYGTAGIARALHLAALALSDDSRRQIAEDALVSAVTDSTQEELVSDASLCH
                     GYAGLARITARAATDATGPAATRLRALASDLLHRARAQPIPDGPGVLEGAAGVGLAALA
                     AVTEPATGWDTCLLIT"
     gene            complement(2900..5974)
                     /locus_tag="FCN18_RS31940"
                     /old_locus_tag="FCN18_31935"
     CDS             complement(2900..5974)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151815.1"
                     /locus_tag="FCN18_RS31940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31935"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_206078025.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.8e-205,
                     bitscore: 676.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-20,
                     bitscore: 65.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-22, bitscore:
                     72.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGALVRAVTHGGLDLPQWPNPSGTGPSAVAAWLDWLRQVWATES
                     VSDAVGHASPRLADQIRTLCATNNPGERETRRAVLSVVRYLARMTGRPTPNGLFAGVAP
                     ASFAHRTDLRWGTAHRAVARGESGWLAEIISQLERRPEVLPNLLVVTNSTVMVRGDRLV
                     VPYRPSVLDRGTGAVEVSLRHTAPVRVALDAARRPIRLEDLCTKVQTDFPDAPPATVTA
                     MLTELVAQGVLVTSLYAPSTQPDALGHLLRELEAAGEAAAKQSAALREIHTLLEQHQRE
                     SLDASRAVRAEAVVRMHRLARTKRHPVAVDLRLDAEIVLPDAVAREAERAAMLLTRLSP
                     YPHGTPLWGDYHRRFYERFGAGTLVPLLELVADSGVGWPDGYPGASAAPGRPQRTRRDE
                     VLLALAQGASLDGRVEVILDEALIAELELTDTGPVRLPSHLELCARVDATSVEALGRGD
                     FRMMVTSVSRAAGVVTGRFLQLLTAGERDALTGALVDMPSEDDVLFAQLSFPPLDPATA
                     HVTRTTQVLPTVISLAEHSNTASADVLTASDLAVGCDSHRLYLTAPTLGRRVEAWGMHA
                     LNLRKHTPPLARLVTELCRAQSAQVTDFDWGAASTLPFLPRLRSGRIVLAAARWRLAAA
                     DLPGRSASWEAWVTALADWQGRRRLPRRVYLVDGDWRLPLDLNEDAHRVLLREHLATHP
                     HAVLEEGPAEDATRWFDGRAHEIVVPLAARQPQTTTRPPRPTPQRIVRPGEHGLPPGAS
                     PLLFAKLYGDAQRQNTVLAEHLPALLAEWGEDQPRWWFLRFREGGEHYLRLRIALPSSD
                     AAVFGEAAGRVSAWTDRLRHQGLLREVAFATSYPETGRWGSCEALAAAEAVFTADSRAV
                     LTQLAQPVRPHHHALAAANFAAIAIAFTGGTAAGMRWLIDHVPAKPPAVVPRPVFAEAR
                     RLADPREDFRVLRGEPGGGAIVATWAERAQALAAYRSRLSGADAEGVDQDVALGSLLHT
                     HFLRTCGIEPEDKAVCLYLARTAALTFTARAGELR"
     aSDomain        complement(5258..5533)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FCN18_RS31940_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.30E-21"
                     /identifier="RREFam001.1"
                     /label="FCN18_RS31940"
                     /locus_tag="FCN18_RS31940"
                     /protein_end="239"
                     /protein_start="147"
                     /score="65.9"
                     /tool="antismash"
                     /translation="LVVTNSTVMVRGDRLVVPYRPSVLDRGTGAVEVSLRHTAPVRVAL
                     DAARRPIRLEDLCTKVQTDFPDAPPATVTAMLTELVAQGVLVTSLYA"
     gene            complement(6101..6271)
                     /locus_tag="FCN18_RS31945"
                     /old_locus_tag="FCN18_31940"
     CDS             complement(6101..6271)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151814.1"
                     /locus_tag="FCN18_RS31945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31940"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_206078022.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.6e-16, bitscore:
                     52.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQMDHAVAPITSTTESEFDLDVTLLEVVDPAHLINMTDDGCGQ
                     TCEKSTCISAA"
     gene            complement(6382..6729)
                     /locus_tag="FCN18_RS31950"
                     /old_locus_tag="FCN18_31945"
     CDS             complement(6382..6729)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FCN18_RS31950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FCN18_31945"
                     /product="hypothetical protein"
                     /protein_id="WP_137096821.1"
                     /transl_table=11
                     /translation="MDEYLASTLNTAVIERLDYLDRLVSKGDEPSRAALAETEIARLTD
                     AWRALLELHAPDEHSRCPECSGWRRPRRHPCTVWTIAHQHLIAADGSPAAGAGRHAAAA
                     GRSTVAVLGAS"
     gene            complement(6722..7063)
                     /locus_tag="FCN18_RS31955"
                     /old_locus_tag="FCN18_31950"
     CDS             complement(6722..7063)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FCN18_RS31955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FCN18_31950"
                     /product="hypothetical protein"
                     /protein_id="WP_137096822.1"
                     /transl_table=11
                     /translation="MGGIREVVAVIVAADSATGRVVKAIDELTAHLPPPDEPWACPLCS
                     TESWPCSRFNAAAHQVMTAGLQIRDWIPNDLHARLWGKPKPRSPAPPAPRPQAAPQSET
                     WFDEESPDG"
     gene            complement(7280..8167)
                     /locus_tag="FCN18_RS31960"
                     /old_locus_tag="FCN18_31955"
     CDS             complement(7280..8167)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670908.1"
                     /locus_tag="FCN18_RS31960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31955"
                     /product="aldo/keto reductase"
                     /protein_id="WP_137096823.1"
                     /transl_table=11
                     /translation="MTADKQNSAPNVLPVGELPTRRLGFGSMQLTGPGHWGAPDNPQQA
                     MQVLRDAVDAGVTHIDTADAYGPFTAEKYIRKALHPYPEGLVIATKGGLTRQGPGKWAP
                     CGRPEYLRQCVEMSLRRLQVERIDLYYLHRIDPAVPMEDQLAVLSDMQAEGKIHHIGLS
                     KVDIGHVRKAGELIDVAAVQNKYNVSNRVFEEVLRHCEIAEIAFVPYAPLATGKLTEPG
                     GVLDELATKYSATPAQLALAWLLHRSPVMMPIPGTSCSTHLHENLVAVQIDLTREDVTA
                     IGLAINDNPAPSPV"
     gene            complement(8301..8912)
                     /locus_tag="FCN18_RS31965"
                     /old_locus_tag="FCN18_31960"
     CDS             complement(8301..8912)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024911.5"
                     /locus_tag="FCN18_RS31965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31960"
                     /product="AAA family ATPase"
                     /protein_id="WP_158303203.1"
                     /transl_table=11
                     /translation="MIGEVEKPVVIGVLGTHSTGKSTFLARLAHDLRRRHIQVATVADL
                     GEQAQRIGLPILHNHTWASTLWFATRGISYELEAWRHGDVVLVDRPVPDALGYYRAALE
                     YRGEQPEPTTLAYLESLVRGHSVHYDLLFCTTLDTSIPLGDNKERDDDGEFRVLADRFV
                     GRVLDDLDLTHELLPADGHDRALFRAIDFVTASLAGEAAV"
     gene            complement(8909..9475)
                     /locus_tag="FCN18_RS31970"
                     /old_locus_tag="FCN18_31965"
     CDS             complement(8909..9475)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013122.5"
                     /locus_tag="FCN18_RS31970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31965"
                     /product="PolC-type DNA polymerase III"
                     /protein_id="WP_137096824.1"
                     /transl_table=11
                     /translation="MEGNGQQPPEIIEIAVLPVDGEVSGEHLRSWLIRPERPINAMVTR
                     KVHGISNEDVAHCPPWSAVATEVEPLLADRTLVAHNASVELNVLTAHLPNWKPPMVLDT
                     LRLVKHVLPNLGGGYGLDNVVRVVELDTSGINEQRYHRAGYDTWCAWKLLLILIELGKL
                     DWDKLIKLAALPGFVPPSEPEGGLW"
     misc_feature    9524..9539
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            complement(9525..10736)
                     /locus_tag="FCN18_RS31975"
                     /old_locus_tag="FCN18_31970"
     CDS             complement(9525..10736)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010693890.1"
                     /locus_tag="FCN18_RS31975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31970"
                     /product="radical SAM protein"
                     /protein_id="WP_228714236.1"
                     /transl_table=11
                     /translation="MTISPTSPAPAQDRPTATSRKPLPILTEQQRAGLRPDLLEVIENR
                     KSGLSLNHVIGCPLDCGYCVRHLFDNFAMKVPRALMSDEQAVDQLVGHPFFQPHVTPIQ
                     LLNRATDPMLPAVKPHTFATLRLLDAHKLTNHVLVISRWRVTPEDCAVLNSFRNIKLTL
                     LITHSGIEHEQVEPVDSTIAATSLRTAFEHAERYRTILYWRPIVPGLNDSDEHLSRALD
                     LSQYAHATVFTGLFYKDQIRAYYRDHGLPEPYQDGARRKVFPEALEQRILAAAQSRPAG
                     GSPLFRKTSCAVTYAHGVADYNGHYGIRELCDICPAAQVQRCAKAWTPPQTRKVAAMTK
                     ALGGRLITINDRAVVVDGLDEQRRYVMQHSLGYQVHDVTKPHHPHRHGRADLGWPAMTK
                     ETTP"
     misc_feature    complement(10362..10364)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10887..12404
                     /locus_tag="FCN18_RS31980"
                     /old_locus_tag="FCN18_31975"
     CDS             10887..12404
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="FCN18_RS31980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31975"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_158303204.1"
                     /transl_table=11
                     /translation="MTHDDAEETTLGEDVEPAAAQLAEGIRRRRKAAELSHAQLAVKVG
                     YSREYVRRAESPRKGLPSIDLVRALDHALGDDGTLLALREQADAARQARRRSRAHSLVA
                     GMSISAVPTTVAGVPALALDTDGRADTEVAVQAPPGRFFTGTSIAARAYPASDDGRILA
                     AVPTGFADDMFLRRPRRGLVIGITENEHGVSLFGLDSRQARRRLAGAPEGARLLMSRAY
                     ALDDLTLGILWAVANLDEALLDDDATLSDSRGQLAAYEQLPRSAAGREIAADLAPVSRM
                     WLGSQFCASHILRHTDTLTDMPAFWTREQRGEEASTWLLFEHKYDYLRQSAGAASGAGT
                     GPTRAFCIPASAVADSSRPERILLLLAVALMESFGITVDVCAEPEYAAVPGFVFDGHRR
                     AIVANWVGADGIWQVDVTDTTPLLREFADATGYARSHSIAAANTPGERLHALANYLELD
                     WAWLVRRCHELGEYGSAGIAQPRSRLLSTEGVDQACRFLALADQGGR"
     gene            12447..13520
                     /locus_tag="FCN18_RS31985"
                     /old_locus_tag="FCN18_31980"
     CDS             12447..13520
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020501957.1"
                     /locus_tag="FCN18_RS31985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31980"
                     /product="asparaginase"
                     /protein_id="WP_228714237.1"
                     /transl_table=11
                     /translation="MLEPSTTLARRVVVFGLGGTIAMTTSDAGGVVPALSADQLVAAVP
                     GLAESGIAVDVEDFRRVPGASLTFDDLAALAIAIDQKLAAGADGVVITQGTDTIEETAY
                     LLDLTHTRSEPIVVTGAMRNPTLAGADGPANLLAAVQTAASADARDLGTLVVFADEIHA
                     AARVRKTHSTSGYTFVSTNGGPLGYVVEGQPRVLNRPSSRTTVPTAAELRPVEVGLITM
                     VLGDSGTLLEAAADRLDGLIVAGFGVGHVPNRVVDTLTKLAAQMPVVLASRTGAGSVLS
                     RTYAFPGSESDLLGRGLISAGFLDPLKARILLHHLLATGRDLADIRAVFAQAGAGHNAT
                     NPRSSHPATTLQGAARA"
     gene            13513..13983
                     /locus_tag="FCN18_RS31990"
                     /old_locus_tag="FCN18_31985"
     CDS             13513..13983
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015444.5"
                     /locus_tag="FCN18_RS31990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31985"
                     /product="PPC domain-containing DNA-binding protein"
                     /protein_id="WP_137096826.1"
                     /transl_table=11
                     /translation="MRSHELTLGRSFAVAFDHGDDFFTALTEFCQQHGVRQGYIPGFIA
                     GFSEVQIVGTCDKLDDPNAPVWTKVHLTNVEAFGGGTLAYDPINDQVAPHIHVAVGLKE
                     QSATGHTSHLLGATVQFLTEMLVIEVASPQMHRVRQRDLYDVPLLRFGPNGE"
     gene            complement(14268..15245)
                     /locus_tag="FCN18_RS31995"
                     /old_locus_tag="FCN18_31990"
     CDS             complement(14268..15245)
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024744.5"
                     /locus_tag="FCN18_RS31995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_31990"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_137096827.1"
                     /transl_table=11
                     /translation="MSAVAPQDATPGTGSTTTSNPQGDGPTETNAEARHLDWPACLNAR
                     DLGGLITKDGGRVCDGVLVRSDRLSRLTPTGVDAVRRIAPGRIIDLRAARQCEREPNPF
                     ADTHLYRNVPLSDPADSPDRQPYLIDRYRSKLDRNLRRFADAVAAVADAPPGAVVVHCQ
                     AGKDRTGLVIALILSAIGVLDEMIAADYAVSAIRLDAHYRAKRARIDDPELLELVHELH
                     SARPDTMLATLAHVRAQYGGAEQYLHHGGLTSRQLQALRTRLLDDKPHRSASEHGCADD
                     GHTKHELLMQRGRLHDGTFTDPPHSSSAVVRGHCGSSRRHFEIN"
     misc_feature    complement(14901..14903)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 cctttctgga tcgcgtcggg caatccgatc ttggtccatc cgcggcttac acagttgtca
       61 tgacacggcc ggacgcggcg ggcgtcgtcg ccgaggcccc gcaggggcat gaagatcgcc
      121 atctcgctgc tcaggctgct ccagccgtcc tggtcgcgtt cgaagacgat gctgcgcgag
      181 gcgcacccgc gcaggcgcac cggggccacc aagcgcccgc tgggtgcgag ctggtcgagc
      241 caggcggtgg ggatctcgtg ggcgccgacg gtggcgatga cgcggtcgaa gggcgcgttc
      301 tccgggtggc cgagcgcgcc gtcggcggcg accgcctcga cgttgctgat gctggcggcg
      361 gcgaggtgct cgcgggcacc ggcgacgagg tcctcgtcga tgtcgatggt ggtgacgtgc
      421 ccggtcgggc cggtcagggt ggccatcagg gaggcgttgt agccggtggc cgcgccgagt
      481 tcgagcagcc gctcgccggg ctgtatgccg agctgttcga gcatcatggc gacgatcttg
      541 ggctgggacg cggcgctgat gcgggtgccg tcgccctcgt gcttggtgta gacgggctcg
      601 tcggcgtacg cctcggtcag cgggaggccg gggaggaaca ggtggcgcgg cacctggcgg
      661 aacgctgcct cgacggcgtc ggtgcggatg gtgccgtcct tgatgaggcg ctcggtgagc
      721 tgggcgcgca gttcgtcggc ggagtcggtg gaggcgtcac tcacagtagt cgtcattgtc
      781 ggaaccctaa cggtgttgga ggtggtcccg gctggtgcct gccgggtagg cgtgctgtgg
      841 aagacggcat cgacggccag cgcaacgagg gtggcttgat cgggtccgga gagtccggcg
      901 cggttggcgt ggaagatgaa gtggtgcgcc aggatcgcgc gcagacctct atcgagctgc
      961 ccttcgcggg cgagcgtggc gagttggctt ccggcggtgt cgaacgccgc gcaccacgtc
     1021 tcaggcacct ggtcaggcgc cacgtcggag atcctgtgcg tgtcggtggt catcagacgc
     1081 cgcacggcct ggttccaccg ctcggtgcgc tgggaatcgg tgtggtgacc gtgggcggcg
     1141 ggccggagtg cagcgacctt agcccagacg tcgccctgct cgaaccagtc gagcccggcg
     1201 gcgcgcagca tcgcgctgaa cagcaggacg gtggtctccc gctgccccaa ggccactggc
     1261 gccgcctcgc aggcgcgggc gaggcagtgg cggctgtcgt ggtggaacag cgtgtgcgcg
     1321 atgtccatcc cggcggggcc gccgaaggcg acggtttcgg gttcgtagat gccgcgggtc
     1381 cagcgggcga cctgtccgtc ggcttccagt tcggccagca gcgtgtcgac cacggtcgtg
     1441 tcggggttga ccggctggta gcgcagccgc caggcgggcg tcttgcgcag gtgccaccac
     1501 ctgtcgagtt cgccgtcctg ctgggcctgg tcgagggcgg gcgccagcaa ggtcgcggcg
     1561 gtgtgctcag cggtggccgg gttggcgaac tcgaccaggt agtggtgcca gcggctgtcc
     1621 ggcggcatcg gggcgggtct cctctctcgt gtcggtcagg tgatcagcag gcaggtgtcc
     1681 cagcccgtcg caggctcggt caccgcggcg agggcggcca agccaacccc ggcggcgccc
     1741 tccagcacgc cgggcccgtc ggggatgggc tgagcgcgtg cccggtggag caggtcactg
     1801 gccagcgcgc ggagccgggt cgcggcgggg cctgtcgcgt cggtcgcggc gcgggcggtg
     1861 atgcgggcga ggccggcgta gccgtggcac agcgaggcgt cgctgaccaa ctcctcctgg
     1921 gtcgagtcgg tcaccgcgct gacgagggcg tcttcggcga tctggcggcg cgagtcgtca
     1981 ctcagggcca gggcggcgag gtgcagggcg cgggcgatac cggctgttcc gtagcaccag
     2041 ctcgggcggc ggtcggcacc gctgtgctgc acgtgcgcgg gcctcgaccg cgcctcttcc
     2101 ctggtgatca tgtagggcca gcggtggccg ccaggggcgt cgatgcgcca ggagtccagc
     2161 cacgcgcaga tcgtctcgac ggcctcgcgc tgcccgtcca cagtgatgcc ccggcgcagg
     2221 gcctgggcca gcagtgccag cgggccgctg atgccgtgcg cgagtccgaa gttgccgtgg
     2281 ccgccgggaa actcgtcctc cactcgaccg gtgggaccgg tgagggtcca ccaccccgga
     2341 agcgcctctc cctcgatcgt caccgggtgg gcaaggcgca ccaaggcacc cagcacggcc
     2401 cgtagagcgg tgccgccatg gtcgtggtgc agcaggtacg cgcccagccc ggcgaggccg
     2461 cggattgtgt cgaactcggc catcaccggc agctccccag cgtccatgcg cctgtgtgcg
     2521 gtgtcgacgc gggcatgggc atcggcggcg acctgccggg ccaacggtgc aagggcagat
     2581 cggtacgtgc cagggcggac cgcggcggcg cccgcaatgg cacgggcgac ggccggcgcg
     2641 ccgtagaagc cgccggtgct cgccccggcg gtgaccggct tgcctgcgac gacggtcagc
     2701 cactcgtggg cgcggtcgaa tggccgtatc ccggctgccg ccagttcgat gtgcagcagc
     2761 gcgacgcctg gagccccgtg ggccagggac tggtgccacc acggctgatc ggtcggcaag
     2821 tcagcgtcgt ccggcagagc gaggcggtcg gcgatctcca ccgcgaacgc gaccgtggtg
     2881 tctgcggcga ggtcggcgtt catcgaagtt ctcccgcgcg ggcggtgaag gtcagggctg
     2941 cggtccgggc caggtagagg cacaccgcct tgtcctcggg ctcgatgccg cacgtccgca
     3001 ggaagtgggt gtgcagcaac gaccccaagg cgacgtcctg gtcgacgccc tcggcgtcgg
     3061 ccccggacaa gcgcgatcgg taagcggcca gggcctgggc gcgttccgcc cacgtcgcga
     3121 cgatcgcgcc cccgcctggt tcgccacgca ggacgcggaa gtcctcgcgg ggatcggcca
     3181 ggcgtcgtgc ctcggcgaac accggccgag gaacaacggc gggcggcttc gctggaacat
     3241 ggtcgatcag ccaccgcatc ccggctgcgg tccctccggt gaaggcgatg gcgatggcgg
     3301 cgaagttcgc ggcggccagg gcgtggtggt gaggccgcac gggctgggcg agctgggtaa
     3361 gaacggcgcg cgagtcggcg gtgaagaccg cctcggcggc tgccagcgcc tcacacgagc
     3421 cccagcggcc ggtctccggg taggaggtcg cgaaggccac ctcgcgcagc aaaccttggt
     3481 ggcggagtcg gtcagtccag gcgctgactc gaccggcggc ttcaccgaac accgcggcgt
     3541 cggagctggg cagcgcgata cgcagacgca ggtagtgttc gccgccttcg cggaaccgca
     3601 ggaaccacca ccgcggctgg tcctcgcccc actccgccag cagcgcgggc agatgctcgg
     3661 cgagcacggt gttctgacgt tgtgcgtcgc cgtagagctt ggcgaacagc agcggggacg
     3721 caccaggcgg caggccgtgc tcaccgggcc ggacgatccg ctgaggcgtc gggcgcggcg
     3781 gtcgcgtcgt ggtctgcggc tggcgagcgg ccagaggcac gacgatctca tgagcccggc
     3841 cgtcgaacca tctggtggcg tcttcggctg ggccttcctc cagcaccgcg tgcgggtggg
     3901 tggcgaggtg ctctcgcagc aacactcggt gtgcgtcctc gttgagatcc agcggcagtc
     3961 gccagtcccc gtcgacgaga tacaccctgc gcggcaaacg gcggcggcct tgccagtcgg
     4021 ccagcgcagt gacccacgcc tcccagctcg cgcttcggcc gggcagatca gcggcagcca
     4081 accgccaccg cgcagcagcc agcacgatgc gtccggagcg caaccgcggc agaaacggca
     4141 acgtcgaggc ggccccccag tcgaagtcgg tgacctgcgc ggactgggcg cggcacagtt
     4201 cagtcaccaa gcgggccaag ggcggggtgt gcttccggag attgagtgcg tgcatccccc
     4261 atgcctccac tctcctgccg agggtgggag ctgtgagata caggcggtga ctgtcgcagc
     4321 cgacggcgag atcgctcgcc gtcaggacgt ccgccgaggc ggtgttgctg tgctcggcga
     4381 ggctgatcac cgtcggtagg acctgcgtgg tccgggtgac gtgtgctgtg gcggggtcca
     4441 gcggcggaaa cgacagttgc gcgaacagca cgtcgtcctc gctcggcatg tcgaccagcg
     4501 caccggtcag tgcgtcccgc tctcctgcgg tgagcaactg caggaatcgg ccggtcacga
     4561 cgcccgcggc gcgggagacc gaggtgacca tcatgcggaa gtccccgcgt ccgagcgctt
     4621 ccacgctggt ggcgtccaca cgggcgcaca gctccagatg ggaaggcagc cggaccgggc
     4681 cggtgtccgt cagttccagc tcggcaatca gcgcctcgtc caggatcact tccacgcgcc
     4741 cgtccagcga tgcgccctgg gccagcgcca gcagaacctc gtcgcggcgt gtccgctggg
     4801 gacgccccgg agcagctgaa gcaccgggat acccgtccgg ccaaccgacg ccgctgtccg
     4861 ccacgagctc caagagcggt acgagcgtgc cggcgccgaa gcgctcgtag aagcgccggt
     4921 gatagtcacc ccacaggggc gtgccgtgcg ggtagggact caagcgcgtc aggagcattg
     4981 cggcacgttc ggcctcgcgg gcgactgcgt cgggaaggac gatctcggca tccagccgca
     5041 gatcgaccgc gacgggatgc cgcttggtgc gggccagacg atgcatccgg acaacggctt
     5101 ccgcacgcac cgcgcgactc gcatccaggg actctcgctg gtgctgctcc agcagggtgt
     5161 ggatctcccg caacgcggcg gactgcttcg ccgcggcctc gcccgccgct tccaactccc
     5221 gcagcagatg ccccagggcg tcgggctggg tactgggtgc gtaaaggctg gtaacgagca
     5281 caccttgtgc gaccagctcg gtaagcatcg cggtcaccgt cgctggtggc gcgtcaggga
     5341 agtcggtctg gaccttggta cacaggtcct ccaagcggat tggtctccgc gcagcatcca
     5401 aggcaacgcg caccggggcg gtgtgccgca acgagacctc gaccgcgccg gtaccccgat
     5461 ctagaacact cggccgatac ggcacgacca agcgatcacc acgcaccatg accgtgctgt
     5521 tcgtgaccac gagcagattc ggcagaactt cgggccgacg ctccaattgg ctgatgatct
     5581 cggccaacca accggattca cctcgggcga cagcccggtg cgcagtgccc caccgcagat
     5641 cggtccgatg ggcgaagctc gctggggcca ccccggcgaa caggccgttc ggagtcggcc
     5701 ggccggtcat gcgggccaga tagcggacga cggacagcac cgcccgccgc gtctcccgct
     5761 cgccgggatt gttcgtagcg cacaacgtgc gtatctggtc tgccaaacga ggactggcgt
     5821 ggccaacggc atcactaaca gattcagtgg cccacacctg gcgcaaccag tccaaccaag
     5881 ctgccaccgc ggacggacca gttcccgacg ggttaggcca ctgcggcaga tccaggccgc
     5941 catgagtaac ggcgcgaacc aatgcaccgc ccatggcgcg gaatcctgcg ccgccgtgga
     6001 tagccgattt caccaggaac ccttcccgtg agagcaagtg tggagaccgg acgccacccc
     6061 gcgccgttcg aggtggtggc gtccggtcaa gtcgtgacga tcaggcggcg ctgatgcagg
     6121 tcgacttctc gcaggtctgc ccgcaaccgt cgtcggtcat gttgatgagg tgagcgggat
     6181 ccaccacctc cagcagggtc acgtcgaggt cgaactccga ttccgtcgtc gacgtgatcg
     6241 gcgctacggc gtgatccatt tgaactgtca cagtttctcc ttcgtgatgg tgcaatttcc
     6301 gggattcgag cattggactc ggaatgagga cttagtggac cggagatggc gccgcgtccg
     6361 gggccgcggc gccgtccccg gtcaggaggc ccccagcact gcgacggtcg accgtccggc
     6421 ggcagccgca tgcctgccgg ctccggccgc gggagaaccg tcggcggcaa tcagatgctg
     6481 atgggcgatg gtccacacgg tgcacgggtg tcgtcgcggg cgtcgccatc ccgagcattc
     6541 cgggcagcgg ctgtgctcgt cgggagcgtg gagttccagc agtgcccgcc acgcgtcggt
     6601 cagtcgggcg atctccgttt ccgccagggc agcacgggac ggctcatcac ctttggagac
     6661 caaccggtcg agatagtcca gacgttcgat tacggccgtg ttgagggtcg aggccaggta
     6721 ctcatccatc gggggactcc tcgtcgaacc aggtttccga ttgcggggcg gcttggggtc
     6781 gtggtgcggg cggggcgggg gatcggggct tcggctttcc ccacagccgg gcgtggaggt
     6841 cgttcggtat ccagtcgcga atctgtagcc cggcggtcat cacctgatgg gcagcggcgt
     6901 tgaaccggga gcacggccag gattcggtgg agcacagtgg gcaggcccac ggctcgtccg
     6961 ggggcgggag gtgcgcggtc agttcatcga tcgctttgac gacgcgcccg gtagcgctgt
     7021 cggctgcgac gatgacagcg acgacctcgc ggatcccgcc catcgatcac gccgccgcgt
     7081 cgggaccggt cggggtctgg taacgccgcg gccgtcgcca tccggtctgt aggtcggtga
     7141 tcaggtagca ggctgcggcc gaatcgtgcg ggagcgggag catgtgaaag ccgttggggg
     7201 cgaacggcgg acacttcccg gctgggatct cggtgtcgcg caagccgagc atggtcaacc
     7261 ttctttgttc gagtcggcgt tagacagggc tgggggccgg gttgtcgttg atggccagcc
     7321 cgatcgccgt cacgtcctcg cgcgtcaggt cgatctgaac tgccaccagg ttctcgtgga
     7381 gatgcgtgct gcagctggtg ccggggatcg gcatcatcac cggggaccgg tgcaacagcc
     7441 atgccagtgc gagctgggcg ggcgttgcgc tgtacttcgt ggccaactcg tcaagcacgc
     7501 caccaggttc agtgagcttg ccagtcgcga gaggcgcgta cggcacgaag gcgatctcgg
     7561 cgatctcgca gtgacgaaga acctcttcga acacacggtt cgagacgttg tacttgttct
     7621 gcaccgcagc gacatcaatc agctcgccgg ccttgcgaac gtgacctatg tctaccttgg
     7681 acaggccgat gtggtggatc ttcccttcgg cctgcatgtc ggagagcaca gcgagctggt
     7741 cttccatcgg gacggcaggg tcgatgcggt ggaggtagta caggtcgatc cgctcaacct
     7801 ggagccgccg caggctcatc tcgacgcact ggcgcaggta ctctggccgg ccgcacgggg
     7861 cccacttgcc tgggccttgg cgagtgagac cgcccttggt agcgatgacc aggccctccg
     7921 ggtacgggtg caacgccttg cggatgtact tctctgcggt gaacggaccg taggcatcgg
     7981 cggtgtcgat gtgcgtcacg ccagcgtcga ccgcatcgcg gagtacttgc atggcctgtt
     8041 gcggattgtc cggagcgccc cagtgaccgg ggccggtgag ctgcatggaa ccgaacccga
     8101 ggcggcgcgt gggcagctca ccgaccggga gaacgttcgg agcggagttc tgtttgtcag
     8161 cggtcatcga tgaattcctt gtggtggttg gacaaagtgg acggtatggg gcggcgtcgc
     8221 cgcgcgctgc gccttggtgg acggcgggat caagggtcgg gggcctcggt cgcttgaacc
     8281 cgccgccggc tttgaggcgg ctacaccgct gcttcgccgg ctagcgacgc ggtgacgaaa
     8341 tcgatcgccc ggaacagagc tcggtcgtgt ccgtctgctg gcagcagctc atgggtcagg
     8401 tcgaggtcat cgagaacgcg gccgacgaaa cgatccgcga gcacacggaa ttcgccgtcg
     8461 tcgtcgcgtt ccttgttgtc gcccaacgga attgaggtgt ccaaagtggt gcagaacaac
     8521 aggtcgtagt ggacactgtg accgcggacg agggattcca agtaggccaa ggtcgtgggc
     8581 tcgggctgct cgccgcgata ctccagcgcg gcacggtagt acccgagggc gtcaggcacc
     8641 ggccgatcca cgagcacgac atcgccgtga cgccacgctt ccagttcgta gctgatcccg
     8701 cgcgtggcga accacagtgt cgaggcccag gtgtggttgt gcaggatcgg caacccgatg
     8761 cgttgggcct gctcgccgag atcagccacg gttgcgacct ggatgtgccg gcgacgcagg
     8821 tcgtgagcga ggcgggccag gaaggtggac tttccggtgg agtgggtgcc aaggactccg
     8881 atcaccacgg gcttttcgac ttcacctatc accacaaccc tccttcgggt tcgctgggtg
     8941 gaacgaaacc tgggagtgcg gccaacttga tcagcttgtc ccagtcgagc ttgccgagtt
     9001 cgatcaagat gagcaggagc ttccaggcgc accaggtgtc gtagccggcg cggtggtagc
     9061 gctgttcgtt gatgccgctg gtgtccaact cgaccacgcg caccacgttg tcgagtccgt
     9121 agccgccgcc gaggttgggc aggacgtgct tgaccagacg cagggtgtcg agcaccatcg
     9181 gtggtttcca gttcgggagg tgggcggtga ggacgttcag ctccaccgag gcgttgtgcg
     9241 cgaccaatgt gcgatcggcc agcagcggct cgacctcggt cgcgaccgcg gaccatggtg
     9301 gacagtgggc tacgtcctcg ttgctgatgc cgtggacctt gcgggtcacc atcgcgttga
     9361 tcggccgttc aggccggatc agccacgacc gcaggtgctc acccgacacc tcgccgtcca
     9421 ctggcagcac cgcgatctcg atgatctcgg gcggctgctg gccgttgccc tccacgtcga
     9481 cacggcaagc tgctggccgt tcagggccgc agggagggaa gcggtcacgg cgtcgtctcc
     9541 ttcgtcatcg cgggccaacc gaggtcggct cgcccgtggc ggtgcgggtg gtgcggcttg
     9601 gtcacgtcgt gcacctggta gcccaggctg tgctgcatca cgtaccgacg ctgctcgtcc
     9661 agcccgtcaa ccaccacggc acggtcgttg atggtgatca gcctgccgcc caacgccttg
     9721 gtcattgcgg caaccttccg cgtctgcggc ggagtccatg ctttcgcgca gcgctgcacc
     9781 tgagccgctg gacagatgtc gcatagttcg cggatgccgt agtggccgtt gtagtcggcg
     9841 acgccgtgcg cgtaggtgac cgcacaggag gtcttgcgga acagcggtga gccaccggcc
     9901 gggcgggact gcgcggcggc caggatgcgc tgttccagcg cctcggggaa gaccttgcga
     9961 cgtgccccgt cctggtatgg ctcggggagg ccgtggtcgc ggtagtaggc gcggatctga
    10021 tccttgtaga acaggccggt gaacacggtg gcgtgcgcgt actggctgag gtcgagcgct
    10081 cggctcaggt gctcgtcgct gtcgttgagg cccggcacga tcggccgcca gtacaggatc
    10141 gtccggtagc gctcggcgtg ctcgaacgcc gtgcgcagcg aggtcgcggc gatggtcgag
    10201 tccaccggct cgacctgctc gtgttcgatc cctgagtgcg tgatcagcag cgtgagcttg
    10261 atgttccgga acgagttcaa caccgcgcag tcctccggcg tgactcgcca gcgggagatg
    10321 accagcacgt ggttggtcag cttgtgggcg tcgagcagtc gtaacgtcgc gaatgtgtgc
    10381 ggcttgacgg ccggcagcat cgggtcggtg gcccggttga gcagctgaat tggggtgacg
    10441 tggggctgga agaacgggtg cccgaccagt tggtcaacgg cctgctcgtc gctcattagc
    10501 gcgcggggca ccttcatggc gaagttgtcg aacaggtgcc gcacgcagta cccgcagtcg
    10561 agcgggcacc cgatcacgtg gttgaggctc agtccgctct tgcggttttc gatcacctcc
    10621 agcaggtccg gccgcaggcc cgcccgctgc tgctcggtca gtatcggcag cggcttccgc
    10681 gaggtcgccg tgggcctgtc ctgagcgggt gccgggctgg tgggcgagat cgtcacaaga
    10741 gcctcctgct cgtggagcgc atgatcgggg agccaattgc catgtgagca ggaccaccta
    10801 tgctcacgga acggggcaac tctgcgacac ggtgtggttg gacccctgtt gccccttctc
    10861 gacacacgca gcgctgggag cccgccatga cccacgacga cgccgaggag accaccctcg
    10921 gtgaggacgt cgagccggca gccgcgcagc ttgccgaggg gattcgacga cgccgcaaag
    10981 cggctgagct cagtcacgcc cagctggcgg tgaaggtcgg ctactcgcgc gagtacgtgc
    11041 ggcgggccga gagtccccgc aagggcttgc cgtcgatcga cctggtccgc gcactcgacc
    11101 acgccctggg tgacgacggc acgctgctgg ccctgcgcga gcaagccgac gccgcgcggc
    11161 aagcacgtcg ccgctcccga gcgcactctc tcgtggcggg aatgtcgata tcggcggtcc
    11221 ccaccacggt ggctggtgtc cccgcactcg ccctggatac cgacggcaga gcagacaccg
    11281 aggtcgccgt gcaggcaccg cctggccggt tcttcacggg aacctcgatc gcggccaggg
    11341 cctacccggc tagcgatgac ggccgcatcc tggccgctgt cccgacgggg ttcgctgacg
    11401 acatgttcct gcggcgcccc cgacgtgggc tggtcatcgg catcaccgag aacgagcatg
    11461 gtgtcagcct gttcgggctg gacagtcggc aggcgcgccg acgattggct ggcgcacccg
    11521 agggggcacg gctgctgatg tcgcgtgcct acgcgctcga cgacctcacc ctcggcatcc
    11581 tgtgggcggt ggccaacctg gacgaagcac tgctggacga cgacgcgacc ctgtcggaca
    11641 gccgggggca actggccgcc tacgagcagt tgccccgctc cgccgccggc cgtgagatcg
    11701 ctgccgactt ggccccggtc tcgcggatgt ggctgggctc ccaattctgc gccagccaca
    11761 tcctgcgcca caccgacacg ctcaccgaca tgcccgcgtt ctggacccgc gagcagcgcg
    11821 gcgaggaggc cagcacctgg ctgctgttcg agcacaagta cgactacctg cgccaatcgg
    11881 ccggtgcagc ctccggggcg ggcacaggcc ccacccgcgc cttctgcata ccggcctcgg
    11941 cagtggccga ctccagccgg cccgaacgga tcctgctgct gctcgcggtg gcactgatgg
    12001 aatcgttcgg catcaccgtc gacgtgtgtg ctgaacccga atacgctgcg gtccccggct
    12061 tcgtcttcga cggccatcgg cgcgcaatcg tggcgaactg ggtcggcgcc gacggcatct
    12121 ggcaggtcga cgtcaccgac accacgccgt tgctgcggga gttcgccgac gcgaccggct
    12181 acgcacgctc ccactccatc gccgctgcca acacgccggg cgaacggctg cacgcgttgg
    12241 cgaactacct cgaactcgac tgggcgtggc tcgtccgccg ctgtcacgaa ctcggcgaat
    12301 acgggagcgc agggatcgcc cagcctcgca gccgcttgct gtccaccgag ggcgtcgacc
    12361 aagcctgccg cttcctcgca ctggctgatc agggaggccg ctaggctgcc aggacatccc
    12421 gaaacccaac cctggaaggg atacctgtgc tcgaaccctc caccacgctg gcacgccgag
    12481 tggtcgtctt cggtctgggt ggcaccatcg ccatgaccac cagcgacgcg ggcggcgttg
    12541 tccccgcgct gtccgccgac cagctggttg ccgccgtgcc agggctggcc gagtccggca
    12601 tcgccgtcga cgtggaggac ttccgccgcg tccccggcgc atcgttgacc ttcgacgacc
    12661 tggccgcgct ggccattgcg atcgaccaga agctcgccgc gggggcggac ggggtggtga
    12721 tcacccaggg caccgacacc atcgaagaga ccgcctacct gctcgatctc acccacacac
    12781 gctcggagcc catcgtcgtc acgggggcca tgcgcaaccc caccctcgcc ggagccgacg
    12841 gaccagccaa cctgctggcc gccgtccaga ccgccgccag cgccgatgcc cgcgacctcg
    12901 gcaccctggt ggtgttcgcg gacgagatcc acgccgcggc ccgcgtacgc aaaacgcact
    12961 ccaccagcgg atacacattc gtctccacca acggcggacc actcggctac gtcgtggaag
    13021 gacagccccg agtactcaac cgcccgagca gccgcaccac cgtccccaca gcagccgaac
    13081 tccgcccggt cgaggtcggc ctgatcacga tggtgcttgg cgactccggc accctcctgg
    13141 aagccgccgc cgatcgcctg gacgggctga tcgtggccgg cttcggcgtc ggacacgtcc
    13201 ccaatcgcgt cgtcgacacc ctcaccaagc tggccgccca gatgcccgtg gtactggcct
    13261 cccgtaccgg agctggctcg gtgctttccc gcacgtacgc cttccccggc tccgaatccg
    13321 acctcctggg ccgaggcttg atctcggccg ggttcctcga tccgctcaag gcccgcatcc
    13381 tgctgcacca cctcctggcc acaggacgcg acctggccga catccgtgcc gtgttcgccc
    13441 aagccggcgc cggccacaac gccacaaacc cgcgctctag ccacccagcc accaccctgc
    13501 agggagccgc ccgtgcgtag ccacgaactg accctcggcc gcagctttgc cgtcgccttc
    13561 gaccacggcg acgacttctt caccgccctg accgagttct gtcagcagca cggcgtgcgc
    13621 cagggctaca tccccggctt catcgccggc ttcagtgagg tccagatcgt cggtacctgc
    13681 gacaagctcg atgaccccaa cgcaccggtg tggaccaagg tccacctgac caacgtcgaa
    13741 gccttcggcg gcggcaccct ggcctacgat ccgatcaacg accaggtcgc tccacacatt
    13801 cacgtcgcgg tcggcctcaa ggaacagagc gccaccggcc acaccagcca cctgctcggc
    13861 gccaccgtcc agttcctcac cgaaatgctc gtgatcgaag tcgccagccc acagatgcac
    13921 cgtgtccgcc agcgcgacct ctacgacgtc cctctcttgc gcttcggacc gaacggcgag
    13981 tagcgacaca gccgggacac caccccgacc ggcgatttcg ggcccgcagg cgtggacggc
    14041 cagaccaccg cggaggtgga agacgccact cagcgccgac aggcgctggg cagagatcat
    14101 ggtgcgagct ccagggagtg tctttggggg atcgctgaca ggcgcgagtg tcagcgtggt
    14161 gttgatgtct ctcgtcggtc aacggcaatg acttgtttgc accgtcaggg ttggatgcat
    14221 cttcggggcc tatctctgac attcctgaca gcaccagcag gtcatggtta gttgatctcg
    14281 aaatgcctgc gggacgagcc gcagtggccc ctcacgacag ccgacgaact gtgaggcgga
    14341 tcggtgaacg tgccgtcgtg caagcgccct cgctgcatca gcaactcgtg tttggtgtgg
    14401 ccgtcgtcag cacaaccgtg ctccgaagcc gaacggtgag gtttgtcgtc gaggaggcgt
    14461 gtgcgcagcg cctgcaactg gcgactggtg agaccgccgt ggtgcaggta ctgctcggcg
    14521 ccgccgtact gggctcgaac gtgcgccaag gtcgccagca tggtgtccgg gcgggcgctg
    14581 tgtagttcgt gaacaagttc cagcagttcg ggatcgtcga tccgggctcg tttggcccgg
    14641 tagtgcgcgt cgagccggat ggcactgacg gcgtagtccg cggcgatcat ctcgtcgagc
    14701 acgccgatgg cgctgaggat cagcgcgatc accagcccgg tgcgatcctt gccggcttgg
    14761 cagtgcacca ccacggcgcc gggcggcgca tccgccacgg ccgccaccgc gtccgcaaag
    14821 cggcggaggt tacggtccag tttggaccga tatcgatcga tcaggtaggg ctggcgatcc
    14881 ggactgtcgg caggatccga taaggggacg ttccggtaga ggtgggtatc cgcgaacggg
    14941 ttcggctcgc gttcacactg gcgagcggcg cgtaggtcga tgatccgtcc gggcgcgatc
    15001 cggcgaaccg cgtcgacgcc agtcggggtg agacgcgaca ggcggtcgga acgaaccaag
    15061 accccgtcgc agacccgacc tccatccttg gtgatcagac cgccgagatc gcgagcattc
    15121 aaacaggccg gccagtccag atggcgggcc tccgcgttcg tttctgtcgg tccgtcgccc
    15181 tgcggattgc tggtcgtagt actgcccgtc cccggagttg catcttgggg agctactgca
    15241 ctcattccgc attagcgatt cgttgaagag cccgagacgg tggagaggcg ctccaccaat
    15301 gaccgcactt cttggttctc ctggtatgcc ttcaacttgt ccgccaggtc cttcacgtac
    15361 ccgaatgccc gatccgaggc gatgtcctgc ccgagcaggt tgagcgcgcg gtggccgtgt
    15421 tcggcggccg tgtccagctc gcccaggccg aggaaggctt cgcccgcgta ggcgtggtag
    15481 aggatcaggt ctcgctcgga cggttcggcg tcaaccacgt tggcctggtc gctcaggtag
    15541 gcgatgcctt gctcgtggtc gcccaccagc gagaagcctc ggcacatctc ggcgaggtgc
    15601 tcaggctggc ggtaccagta cagccagtcg ggatcgtcct cgatccggcg gcggccgaac
    15661 cgttcgctgg cgcggtcaag ggcacggcgg aagctctcac ggttgcccgc gagcgagtgc
    15721 gcgcgggact cccaggcatc gagcatggag agtacgccag gggtgtttac gcccttgccg
    15781 ccgtgcctgg cgctgtcgag cagcaggagc gattcgcggt actggtcgag attcgacgcc
    15841 tggaaggcca gcatcgacag cacgtacacc ccgagcagcc ggtcacccga gacgtgcgcc
    15901 gcgtacagcg cggtctggta gtagcgctgg gcgagctcgt gcttgccgtc gtcataggcc
    15961 gcccagccgg cgag
//
