LOCUS       NZ_SWMS01000004        21484 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Prauserella endophytica strain CGMCC 4.7182 Scaffold4, whole genome
            shotgun sequence.
ACCESSION   NZ_SWMS01000004
VERSION     NZ_SWMS01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Prauserella endophytica
  ORGANISM  Prauserella endophytica
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Prauserella; Prauserella
            coralliicola group.
REFERENCE   1  (bases 1 to 390627)
  AUTHORS   Liu,J.M., Habden,X., Guo,L., Tuo,L., Jiang,Z.K., Liu,S.W., Liu,X.F.,
            Chen,L., Li,R.F., Zhang,Y.Q. and Sun,C.H.
  TITLE     Prauserella endophytica sp. nov., an endophytic actinobacterium
            isolated from Tamarix taklamakanensis
  JOURNAL   Antonie Van Leeuwenhoek 107 (6), 1401-1409 (2015)
   PUBMED   25832628
REFERENCE   2  (bases 1 to 390627)
  AUTHORS   Li,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-2019) Yunnan Institute of Microbiology, Yunnan
            University, No. 2 Cuihu North Rd, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 10.16x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_005146945.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:32:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,852
            CDSs (total)                      :: 7,795
            Genes (coding)                    :: 7,703
            CDSs (with protein)               :: 7,703
            Genes (RNA)                       :: 57
            rRNAs                             :: 1, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 34 of 92
            Pseudo Genes (incomplete)         :: 69 of 92
            Pseudo Genes (internal stop)      :: 2 of 92
            Pseudo Genes (multiple problems)  :: 13 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:09:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 221732
            Orig. end                         :: 243216
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SWMS01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21484
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="3"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21484
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21484
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11484](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11484)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            complement(407..1726)
                     /gene="mftF"
                     /locus_tag="FCN18_RS10245"
                     /old_locus_tag="FCN18_10245"
     CDS             complement(407..1726)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152863.1"
                     /locus_tag="FCN18_RS10245"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969).; Members of this protein family, MftF,
                     are glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10245"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_137094650.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.4e-16,
                     bitscore: 54.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPGTRLTLDDSVRRRGPLLIGGSPLRLVRLGKAGTRLLDRWLAG
                     EPLGDGPSEERLARRLLDAGLVHPSPPPLLTAADVTVVVPVKDNPGGVKRVLSATTEVA
                     ERIVVDDGSREPLPGANVRHERPGGPAAARNAGWRLAGTELVAFLDSDTEPEPGWLDAL
                     LPQFSDPTVLAVAPRIRSVPGDDVLARYEADRSSLDLGARPAPVRPMSRVSYVPSAALV
                     VRRSALSAVDGFDTGLRFGEDVDLVWRLLELGAVRYEPTAVVTHEPRAALRPWLRQRFE
                     YGTSAAPLSRRHPGKLSPARLSAWSAAAWALLALGRPWLALALAAGSTALLPRRLRGRG
                     VPVPESLRLAALGHLGAGRLLAEATRRAWWPAALLTARGRRVLLAALVPCAAEALGHSP
                     AWLALRIADDLAYGAGVWTGCLRERTPAALLPAFTEGALR"
     gene            complement(1854..2633)
                     /locus_tag="FCN18_RS10250"
                     /old_locus_tag="FCN18_10250"
     CDS             complement(1854..2633)
                     /NRPS_PKS="Domain: PKS_KR (2-176). E-value: 1.1e-10. Score:
                     33.7. Matches aSDomain:
                     nrpspksdomains_FCN18_RS10250_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658593.1"
                     /locus_tag="FCN18_RS10250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10250"
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_113640984.1"
                     /transl_table=11
                     /translation="MSVALVTGAARGIGAAVVRRLATTGWQVVAVDRCADDPRVPYPLG
                     TREELAALAASYPDSVLDVVADVQDLAGLRSAVALAEERFGGLDAAVAAAALMAGGRPL
                     WESDDTEWDALFSVGVTGIANLARAAIPAMLRRPQPRQGRFVALASAAAHHGLWHLAGY
                     NAAKHAVVGLVKGLATDLRGTGICATAVSPGSTRTDMLTATARLYDLGDVEEFASHQLV
                     ERLLEPDEVAAAVCFLCSPESSAITGTVVHADGGFAP"
     aSDomain        complement(2106..2627)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FCN18_RS10250_PKS_KR.1"
                     /evalue="1.10E-10"
                     /label="FCN18_RS10250_PKS_KR.1"
                     /locus_tag="FCN18_RS10250"
                     /protein_end="176"
                     /protein_start="2"
                     /score="33.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGAARGIGAAVVRRLATTGWQVVAVDRCADDPRVPYPLGTR
                     EELAALAASYPDSVLDVVADVQDLAGLRSAVALAEERFGGLDAAVAAAALMAGGRPLWE
                     SDDTEWDALFSVGVTGIANLARAAIPAMLRRPQPRQGRFVALASAAAHHGLWHLAGYNA
                     AKHAVVGLVKG"
     CDS_motif       complement(2559..2621)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FCN18_RS10250_0001"
                     /evalue="4.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="FCN18_RS10250"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LVTGAARGIGAAVVRRLATTG"
     gene            complement(2630..3490)
                     /locus_tag="FCN18_RS10255"
                     /old_locus_tag="FCN18_10255"
     CDS             complement(2630..3490)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04503.1"
                     /locus_tag="FCN18_RS10255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10255"
                     /product="mycofactocin-associated electron transfer
                     flavoprotein beta subunit"
                     /protein_id="WP_137094653.1"
                     /transl_table=11
                     /translation="MAEPLRPLVVALLRWTDARARIDPLSGEVETDPRGAGPSEADRCA
                     LEHALRIAEAAAGRCVAVTLAPEPAEELLRDALACGADAVLRVDVPSWDSRVPDSGATT
                     ARALAHAIRTELGEPSLVLTGDHSADRGTGSTPAFLAAELGCAQALGLVELSYADGELL
                     ALRRLDRGRRERLAVPLPAVCSVEPAGLRLRRAALPSTLAARTATIPVVTGSVAAEPVT
                     AHAARPFRPRAKELPPPPEADPRLRLLRLTGAHEHREPPRVVVTDDPAEAADELLEYLR
                     GKGYL"
     gene            complement(3483..3779)
                     /locus_tag="FCN18_RS10260"
                     /old_locus_tag="FCN18_10260"
     CDS             complement(3483..3779)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152866.1"
                     /locus_tag="FCN18_RS10260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10260"
                     /product="ferredoxin family protein"
                     /protein_id="WP_112271674.1"
                     /transl_table=11
                     /translation="MNQRYGDVSFEDRMSHVDFRVAEQPHIVVDTDVCRSCTTKTCVHA
                     CPANLFVPTAEGGILFNYEQCFECGTCYLMCDGGNAISWSYPDGGQGVVFRHG"
     gene            complement(3844..5193)
                     /locus_tag="FCN18_RS10265"
                     /old_locus_tag="FCN18_10265"
     CDS             complement(3844..5193)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119: halogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027340.1"
                     /locus_tag="FCN18_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10265"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_137094655.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.1e-08, bitscore:
                     27.3, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 5.5e-10, bitscore: 33.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDRAGPASSAVTVAEPERPQFDAIVVGAGPAGSAAALELARAGH
                     SVALLERGPFPGSKNVYGGVVYGRILDELIPGWYDEMPVQRWVTRRQTMLLDGERSMTV
                     DFRSQSWGRAPYNGATTYRAEFDDWLAGHAQKAGAVLVPSTVATRLLRTERGRIVGVRT
                     DRPDGDLTAKVVIACDGVNSFLAKQAGLFPGDQAAHTTLGVKETLALPARTIDERFGVS
                     GHEGVDIEMLGCTQGIPGGGFLYTNSDTLSVGLVLGLQGLAKSGKRPEEVLAELKRHPS
                     IQPLVRGAELVEYSAHLIPEGGYDTMPQLVGDGLLVAGDAAAMCLAAGIWLEGVNFAMG
                     SGMYAGRAASKALSSGDLGALREYRGLLESSFVLADHKKLRKAPELVLSERVQQRYPGL
                     VCDLVELMFTVENPKPKPGVRKLLRASAKRNGVKMRELARDALTGLRSFG"
     gene            complement(5186..6133)
                     /locus_tag="FCN18_RS10270"
                     /old_locus_tag="FCN18_10270"
     CDS             complement(5186..6133)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152868.1"
                     /locus_tag="FCN18_RS10270"
                     /note="Built with help from friend_finder, bracket5, and
                     grep mycofactocin; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10270"
                     /product="mycofactocin-associated electron transfer
                     flavoprotein alpha subunit"
                     /protein_id="WP_137094657.1"
                     /transl_table=11
                     /translation="MNVPVNTDSLALLVIRRGVAPLGGDEAVAEADGNALLVGSGCAQA
                     ADQLPPLRRAWCAEAGDFAAGAWAGALAPLLRDVRRVVLPASADGRDLAPRLAAELDRP
                     LLAGAVRIGEQCADLARWDGRLSVTVETSRPFVATLVPGVRGSAPAEGTPEVTHVDLDV
                     PESPDARVLEVLDPDPATADLAEAPRILGAGAGLARGALTGPESLALLGEVASALGASV
                     GATRVVTDAGWAPYERQIGTTGVVVDPDLYVAFGVSGATQHTGGLGNPRHVVSVNTDGS
                     SPMTAMADLGLVTDAQELLRELARRLDTPGSNDA"
     gene            complement(6130..8094)
                     /locus_tag="FCN18_RS10275"
                     /old_locus_tag="FCN18_10275"
     CDS             complement(6130..8094)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152869.1"
                     /locus_tag="FCN18_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10275"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 2"
                     /protein_id="WP_112271680.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.4e-10, bitscore:
                     34.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATSRYRYLFSPLRLGPVTLANRVVFSAHLTNYAKEGLPSEQHA
                     AYYAARAKGGAGLIITEEHSTHPTDWPYEKLIHGFHPEVIPGYRRITEAVHAHGVPIFA
                     QLNHNGGQASSMYSRLPVWAPSPVPDPLFREVPKAVTVAEIDEIVAGYAKVAEHCRAGG
                     FDGVELQCSHSSIVRGFLSPATNVRTDDYGGSLENRARILLRLVAAVREAIGPGMALGV
                     RLCGDELIEGGTTIDEAVEVAKWVEASGHVDYINTSIGVATSTLYMIEASMSIPPGYAM
                     FIPSALRKAVDLPVVGVGRFKDPLQADRALAEGHADLIGVVRGQIADADFVAKARAGHA
                     TEIRTCLSCNQECVGRMGLNRWLGCIENPRTGKESVALPMPTRRGRRVVVVGGGPAGLQ
                     AAATAAERGHEVTLLERNQTTGGQASVAASVPSRAEFLDVVRNSLSECHRYGVDVRTGV
                     TATADDIRALNPEVVVLATGAKPQAPWWAGGIERIVDVRDVLEGRVAPEGDVVVIDDLG
                     FHQATSVAELLADRGCTVRISTSGMVVGQDLGVTLDMETFNVRAAAKGITQTTDEVVLG
                     AEEDAGGVRLQVLTHTTGSTTDVRCDWVVCATHQAPEDELWHELSGSAEFEVYRAGDCV
                     APRRAHAAVVEGHRVAVAL"
     gene            complement(8091..10004)
                     /locus_tag="FCN18_RS10280"
                     /old_locus_tag="FCN18_10280"
     CDS             complement(8091..10004)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010310363.1"
                     /locus_tag="FCN18_RS10280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10280"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 1"
                     /protein_id="WP_137094660.1"
                     /transl_table=11
                     /translation="MKLTEPVTLAGRRAPSRVLFGPHETNLARGRAISEAHVAYYERRA
                     AGGAGLIVTETASVHDSDWPYERAPLAADCGAGWASVVRACRPHGTLVLAGLGHAGSQG
                     SSAFSQQALWAPSRVPDVASREMPMEMEAAEIRAVVAGFTRAAELAVEADLDGVEVDAG
                     QHSLLRQFLSGLTNQRGDAYGTDKALLLREVLAAVRARIGDGRVLGLRLSCDELAPWAG
                     ITPDQAQALARDLAREVDYLVVVRGSAMGTSATRPDSHTEPGFNVELCRGIREAVAGAA
                     PVILQGSVVEPGQAEQALADGVADLVEMTRAQIADADLVRKLGTTEPVRPCTLTNQKCR
                     VRDNRNPIVSCIGDPRSGHETGDAPLTGTDPARSVLVVGGGPAGLEAARVLALRGHRVR
                     LVERDAELGGMLALAARVPGRDRLGNLARWLAGEVHRLGVEVALNTEADLAELSGDVVV
                     ATGSVAGPRSYTVHDGGFVLDVVDLLKAPGRLPEGPVAIYDTVGDAVGVGIAELAAAAG
                     RPTTIITQDQVVGTQLALTGDLADANARLQRAGVRLAKRSLLREVHAGHVVVTDAYTGT
                     ATELECATLIHCGHRLPDPTPVPAGMVEAGDRVAPRSVHEAVLEGRRAALAFAAKPLAV
                     HR"
     gene            complement(10001..11203)
                     /gene="mftC"
                     /locus_tag="FCN18_RS10285"
                     /old_locus_tag="FCN18_10285"
     CDS             complement(10001..11203)
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152871.1"
                     /locus_tag="FCN18_RS10285"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="FCN18_10285"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_112271684.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.1e-40, bitscore:
                     134.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.8e-27, bitscore: 90.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 6.3e-09, bitscore: 30.1,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.5e-15, bitscore:
                     51.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.8e-06, bitscore: 22.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLVEHFQHGLDAPICLTWELTYACNLSCVHCLSSSGRRDPRELS
                     TEECKAVIDELQRLQVFYVNIGGGEPTIRPDFWELVDYAVAHDVGVKFSTNGVRITPER
                     ARWLAGTDYVDVQLSLDGATAEVNDYVRGPGSFDTTMRAMENLRDAGFKDFKISVVMTR
                     HNVGQLDEFKRIADDYGAQLRITRLRPSGRGADTWDELHPTADQQLELYEWLIDHGENV
                     LTGDSFFHLNALGSTPLPGLNLCGAGRVVCLIDPIGDVYACPFAIHDEFLAGNVRDEGG
                     FTSVWRTSELFERLRAPQTGGACTSCSAYDSCQGGCMAAKFFTGLPLDGPDPECVKGNG
                     ERALALVGGGSEKPKPDKDHSKPNRTKRGRVGVSIGWGPPEPDRLPDRACDTSPLAGFR
                     P"
     gene            complement(11200..11484)
                     /gene="mftB"
                     /locus_tag="FCN18_RS10290"
                     /old_locus_tag="FCN18_10290"
     CDS             complement(11200..11484)
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018332343.1"
                     /locus_tag="FCN18_RS10290"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="FCN18_10290"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_112271686.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 6.2e-28,
                     bitscore: 91.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDRFAPDRPYRLSSSVALRPEPFGALVYDFTTRKLSFLKTQLL
                     VNVVRELENQPDARSALDSAEVPEAEHKRYLDALAGLLSAGTIEARGTS"
     aSDomain        complement(11221..11460)
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FCN18_RS10290_Mycofactocin_RRE.1"
                     /evalue="4.50E-29"
                     /identifier="RREFam016.1"
                     /label="FCN18_RS10290"
                     /locus_tag="FCN18_RS10290"
                     /protein_end="88"
                     /protein_start="8"
                     /score="91.5"
                     /tool="antismash"
                     /translation="DRPYRLSSSVALRPEPFGALVYDFTTRKLSFLKTQLLVNVVRELE
                     NQPDARSALDSAEVPEAEHKRYLDALAGLLSAGTI"
     misc_feature    complement(11425..11427)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11474..11563)
                     /gene="mftA"
                     /locus_tag="FCN18_RS10295"
                     /old_locus_tag="FCN18_10295"
     CDS             complement(11474..11563)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658597.1"
                     /locus_tag="FCN18_RS10295"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10295"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_110342009.1"
                     /transl_table=11
                     /translation="MNESAATEVTVEEDLLVEEVSIDGMCGVY"
     misc_feature    complement(11595..11615)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            11632..12249
                     /gene="mftR"
                     /locus_tag="FCN18_RS10300"
                     /old_locus_tag="FCN18_10300"
     CDS             11632..12249
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007026930.1"
                     /locus_tag="FCN18_RS10300"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="FCN18_10300"
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_112271688.1"
                     /transl_table=11
                     /translation="MEGIGAKAVSEPSVRPGRRRSTSQHELEAVAFELFEREGFDATTV
                     DAIAKSAGIGRRTFFRYFESKNDVVWGSFTEQLDHMRERFAQRPADEPLMESVRAVVVE
                     FNRVDPAEVPKHRRRMELILRVPALQAHSTLRYGDWRAVVAEYAAKRLGEKPAALRPQA
                     IAYAALGVSLAAYEHWLAETDLQLCDVLDEALSELARGFVLG"
     gene            12289..13578
                     /locus_tag="FCN18_RS10305"
                     /old_locus_tag="FCN18_10305"
     CDS             12289..13578
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005454111.1"
                     /locus_tag="FCN18_RS10305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10305"
                     /product="acetyl-CoA carboxylase biotin carboxylase subunit
                     family protein"
                     /protein_id="WP_112271690.1"
                     /transl_table=11
                     /translation="MKNIFVLALDEENRRTLRDIRNADSYAFHSLLTVDETQVGEIDFE
                     QLLDKAQSQLDAFDGSIDAIVGYWDFPVSTLRAILCHRYGLPGPSLASIVKCEHKYWSR
                     LEQQKAIDEYPRFGIVDLDDEQPSPPDGVRYPMWLKPVKSYSSELAFLVRDESEFDKAV
                     AEIREGISRVGKPFEQVLDMLELPREIAEVGGQACLAEEALSGVQCATEGYVYNGEVVV
                     YGVLDSVNYEGRSSFLRHQYPSQLPKAAVDRMIDVSKRIIGQIGMDNSTFSIEFFCEPE
                     SGDVCLLEINPRHSQSHAEMFECVDGMPNHHAMVMLGLGRDPALPDDKGEYGIAAKWYY
                     RRFSDALVRKVPTAEEIERVHREIPGVIIDIVPVAGQRLSDLPGQDSYSFELAHVFVGA
                     RDETELKDKYERTVEALDFEFAEEGPEKEG"
     gene            13580..15601
                     /locus_tag="FCN18_RS10310"
                     /old_locus_tag="FCN18_10310"
     CDS             13580..15601
                     /NRPS_PKS="Domain: Abhydrolase_1 (66-150). E-value:
                     1.1e-10. Score: 33.5. Matches aSDomain:
                     nrpspksdomains_FCN18_RS10310_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005454113.1"
                     /locus_tag="FCN18_RS10310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10310"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_137094662.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-08, bitscore: 29.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 4.9e-08, bitscore:
                     27.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRAVGSLPCQTTEDEHVWIPVSDGTRLAAKIWRPVSSDDQPVPG
                     ILEYIPYRKRDLTAVRDSIHHPYLAGHGYACVRVDIRGTGESEGVLTDEYLELEQRDAE
                     DVLEWIANQPWCDGRTGMMGISWGGFAALQVAARKPETLRAIAIASFTDDRYSDDFHYM
                     GGCLLSDNLAEAGTMFAHGTLPPDPALVGDRWRDMWRERIEASGPWVDTWLLHQRRDDY
                     WRHASVCENYSGVRCPVLASSGWADGYSNAVARLLANLDVPRKGLVGPWSHKYPHLGEP
                     GPAIGYLQELVRWWDHWLKDVDNDVMDGPMLLTWMQDSVPPSTSYEDRPGRWVGEPSWP
                     SPNVRDVELPLSRHRIGRPGEEVADEPLTVQSPLSVGQFAGKWASYNAPPDMPYDQREE
                     DGGSLVFETDPLPETCEIHGAPRVCLEISADQPVAMVAARLSDVLPDGRATRVTYGVLN
                     LTHRDGHDIPKPLEPGKRYQVSFDLNVVAQAFPAGHKIRLSLSSSYWPLVWPSPEQTCL
                     TVHTGGSGVRLPLRTGGEEQVHRPFAEPEGAEPITVTQVEPGEHRWTVTRDLVDYESAL
                     EIVKDNGTVHYEDIDLDVSRRAYERYSSVADDFSSPRAETEWTMRFARGDWSATTVTRT
                     VLTCTSTEFRLHATLDGYEGEKRLFSRNWQRAIPRDCV"
     aSDomain        13778..14029
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FCN18_RS10310_Abhydrolase_1.1"
                     /evalue="1.10E-10"
                     /label="FCN18_RS10310_Abhydrolase_1.1"
                     /locus_tag="FCN18_RS10310"
                     /protein_end="150"
                     /protein_start="66"
                     /score="33.5"
                     /tool="antismash"
                     /translation="PYLAGHGYACVRVDIRGTGESEGVLTDEYLELEQRDAEDVLEWIA
                     NQPWCDGRTGMMGISWGGFAALQVAARKPETLRAIAIAS"
     gene            complement(15690..15977)
                     /locus_tag="FCN18_RS10315"
                     /old_locus_tag="FCN18_10315"
     CDS             complement(15690..15977)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FCN18_RS10315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FCN18_10315"
                     /product="hypothetical protein"
                     /protein_id="WP_112271694.1"
                     /transl_table=11
                     /translation="MKRKRIFAFFAALALSFGLMSGIASATIHPIVESFDCANEAAFAH
                     HPLGDVADPIGQTPGVGAHSDQSSLRAVQSASANAFSEHKLNGECGKVGQ"
     misc_feature    complement(16067..16083)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            complement(16143..16607)
                     /locus_tag="FCN18_RS10320"
                     /old_locus_tag="FCN18_10320"
     CDS             complement(16143..16607)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019806428.1"
                     /locus_tag="FCN18_RS10320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10320"
                     /product="GreA/GreB family elongation factor"
                     /protein_id="WP_112271696.1"
                     /transl_table=11
                     /translation="MTSTGGLSPATRARLEKELESLREQRESLAPRLGEDPLGDSADQA
                     DLLERAEVVSRLDRRIAEVYDLLHGGPTADSESALPSGTKVSLKFSDGSVEDMVVVGFT
                     EEADEDDASTLTADSPLGRAITGHKKGDTITYRTPAGEVSAEILKLKLPA"
     gene            complement(16679..19054)
                     /locus_tag="FCN18_RS10325"
                     /old_locus_tag="FCN18_10325"
     CDS             complement(16679..19054)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003729 - mRNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152876.1"
                     /locus_tag="FCN18_RS10325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10325"
                     /product="Tex family protein"
                     /protein_id="WP_199542423.1"
                     /transl_table=11
                     /translation="MPNVAEKVSIHQKIADELGVREGQVRAAVTLLDEGSTVPFIARYR
                     KEVTGALDDTQLRTLEDRLRYLRELEERRTTILESIRSQGKLDAELEARIMAAEEKARL
                     EDIYLPYKPKRRTKAQIAKEAGLEPLADGLLSDPTTEPQAAAAVFVDPEKGVADAAAAL
                     DGAKAILVERFAEDADLIGELRERMWTRGWVTSKVRQGKETEGAKFSDYFDFAEPFTKL
                     PSHRILALFRGEKEEILDVATEPEEPPAPDAEPKRGPSDYEIRIAEKFGISDQGRAGDK
                     WLNDTVRWAWRTKILLHLGIDLRMRLRQAAEDEAVRVFAANLRDLLLAAPAGTRTTMGL
                     DPGYRTGVKVAIVDGTGKVVATDTIYPHKPQSQWDQSLAKLEHLAREHNVQLIAIGNGT
                     ASRETDKLAGELVKLRPELKLTKIVVSEAGASVYSASAYAAQELPGLDVSLRGAVSIAR
                     RLQDPLAELVKIDPKSIGVGQYQHDLAESKLSRSLDAVVEDCVNAVGVDLNTASVPLLS
                     RVSGIGTTLAENIVAHRDDNGPFRSRTALKEVARLGPKAFEQCAGFLRIPDGDDPLDAS
                     SVHPEAYPVVRRILDETNVGIRELIGDARTLRALQPEKFVDDTFGLPTVTDILAELEKP
                     GRDPRPEFKTATFAEGVEKMTDLTPGMRLEGVVTNVAAFGAFVDIGVHQDGLVHVSAMS
                     RNFVKDPREVVKPGDVVRVKVLEVDVARKRISLTLRLDDEAKPGGGEQRQSGQGGGRGG
                     QRGRGGKPQQQRQGQGRQRQAPAGGAMADALRKAGYGR"
     misc_feature    complement(19013..19027)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.13"
                     /tool="antismash"
     gene            19088..20761
                     /gene="ilvD"
                     /locus_tag="FCN18_RS10330"
                     /old_locus_tag="FCN18_10330"
     CDS             19088..20761
                     /EC_number="4.2.1.9"
                     /GO_function="GO:0004160 - dihydroxy-acid dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007026113.1"
                     /locus_tag="FCN18_RS10330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10330"
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="WP_112271697.1"
                     /transl_table=11
                     /translation="MADYDIKPRSRAVTDGIERAAARGMLRAVGMGDEDFAKPQIGIAS
                     SWNEITPCNLSLQRLAEASKKGVHAGGGFAMEFGTISVSDGISMGHEGMHFSLVSREVI
                     ADSVETVMEAERLDGAVLLAGCDKSLPGMLMAAARLDVAAVFLYAGSTLPGTVDGREVT
                     IIDAFEAVGACARGLMTREEVDKIERAICPGEGACGGMYTANTMACVSEALGMSLPGSA
                     SPPSVDRRRDGFARASGEAVVELLRKGITARDILTREAFENAIAVVMALGGSTNAVLHL
                     LAIANEAQVELTLDDFSRIGDRVPHLADVKPFGRHVMTAVDRVGGVPVVLKALLDAGLV
                     HGDCLTVTGRTLAENLAELGPPELDGEVLRKLSDPIHPTGGLTILHGSLAPEGAVVKSA
                     GFDASRFEGTARVFDGEQAAMDALGELKAGDVVVIRNEGPRGGPGMREMLAVTGAIKGA
                     GLGKDVLLLTDGRFSGGTTGLCIGHVAPEAAHGGPIAFVEDGDPIVLDLAARTLDVGID
                     EAELARRREGWEQPPPPRRTGVLAKYAKLVGSAAQGAVCS"
     gene            20758..21444
                     /locus_tag="FCN18_RS10335"
                     /old_locus_tag="FCN18_10335"
     CDS             20758..21444
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152879.1"
                     /locus_tag="FCN18_RS10335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FCN18_10335"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_137094665.1"
                     /transl_table=11
                     /translation="MTRTALVTGGTGGLGVAVTRALLGDGWRVVVPWITEAELERLEPT
                     EGLELVRADLFEAADARRCAEQAAGVTRAPLRAVVNLVGGFAMGERVAETPVEDFEQQL
                     RLNLRPTYLVSQAAVPHLIEAGGGAIVCMSSRAALHPFPGAAGYVTSKAAVLGLVGALD
                     AEYSRRGIRVNAVLPSMIDTPANRASQPGADRSRWVSPERIAKVIAFLCGDDAGVVSGA
                     HVPVYG"
ORIGIN
        1 ctcgacgagc acgagttcca gtgcctcctg cccgatcgac agcgtccccg ggaagcccgc
       61 gtgctcgccg ctcgacccgt acggtaacgc cggtgccacg accacgccgg gcacgcgctc
      121 ggcgagccgt cgcgccagct cctcggcgac ggtggtgtcg gtgtcgagcg gcaggtgcgg
      181 gccgtgctgc tcggtcgcgc ccagtggaac ggccagcagc gcgcgcggca cctcaggcca
      241 gcgcaggttc gccagggagg tcatcgcggc gtgccctcgg tgcgggggtg cgttcgcgga
      301 ggctgcccgt ccacaccccg gcgccgcagg tggggtcgtc ggcgggctac gcgggtgggc
      361 tcggtggtgg gcgttgcctc gggccagggc aagcgggaca ccgacgtcat cgcagcgcgc
      421 cctcggtgaa tgcgggcagc agtgccgcgg gggtgcgttc gcggaggcag cccgtccaca
      481 ccccggcacc gtaggcgagg tcgtcggcga tccgcagggc cagccacgcc ggcgagtgcc
      541 cgagtgcctc cgccgcgcac ggcaccagcg cggccagcag cacgcggcgt cccctcgcgg
      601 tgagcagcgc ggcgggccac cacgcgcggc gcgtggcctc cgcgagcagc ctgcccgcgc
      661 cgaggtggcc gagcgccgcc agccgcaggg actccggcac cggcacgccc cggccccgca
      721 gcctgcgcgg cagcagtgcc gtcgagccgg ccgcgagcgc gagggcgagc cacggcctgc
      781 cgagcgccag cagtgcccac gccgccgcgc tccacgccga cagccgcgcc ggactcagct
      841 tgccgggatg ccgccgcgac agcggggccg ccgacgtgcc gtactcgaac cgctgccgca
      901 gccacgggcg cagcgcggct ctcggctcgt gcgtcaccac ggcggtgggc tcgtagcgca
      961 cggcaccgag ctcgagcagc cgccacacca ggtcgacgtc ctcgccgaag cgcagaccgg
     1021 tgtcgaaacc gtccacagcg gacagcgcgg agcggcggac gacgagcgcc gcgctcggca
     1081 cgtagctcac gcggctcatc ggtcgcaccg gcgcggggcg ggcaccgagg tcgaggctcg
     1141 accggtcggc ctcgtaccgc gcgagcacgt cgtcgcccgg cacgctgcgg atccggggcg
     1201 ccacggcgag cacggtcggg tcggagaact gcggcaggag cgcgtcgagc cagcccggct
     1261 caggctcggt gtcggaatcg aggaacgcca ccagctcggt gcccgccagc cgccagcccg
     1321 cgttgcgtgc ggcggcgggc ccgcccggcc gctcgtgccg cacgttcgcg ccgggaagcg
     1381 gctcgcgcga gccgtcgtcg accacgatcc gctccgcgac ctcggtggtc gcggacagca
     1441 cgcgtttgac cccgccgggg ttgtccttca ccggcaccac gacggtcacg tcggccgcgg
     1501 tcagcagggg cggcggactc gggtgcacga gcccggcgtc cagcagcctg cgcgcgagcc
     1561 gttcctccga ggggccgtcg cccagcggtt cgccggcgag ccaccggtcg agcagccggg
     1621 tgcccgcctt gccgagccgc acgaggcgaa gcggtgagcc gccgatgagc agggggccgc
     1681 gcctgcgcac ggagtcgtcg agcgtgagcc gcgtgccggg cttcacgacg tggcacctcc
     1741 ctccggacgt acggatcgcc gacgggaacg cagaactcgc ggtccggaac gcagaactcg
     1801 ccgacgggaa cgcagaactc gccgtccgga acgcagaact cgcgggcccg gcttcacggc
     1861 gcgaagcctc cgtccgcgtg cacgaccgtg cccgtgatgg ccgaggactc tggcgagcac
     1921 aggaagcaca ccgccgccgc gacctcgtcg ggctcgagca gccgctcgac cagttggtgg
     1981 gaggcgaact cctcgacgtc gccgaggtcg tagagccgcg ccgtcgccgt gagcatgtcc
     2041 gtgcgggtcg agcccggcga caccgcggtc gcgcagatgc ccgtgccacg caggtcggtg
     2101 gcgagcccct tgacgagccc gaccaccgcg tgcttggcgg cgttgtagcc cgcgaggtgc
     2161 cacaggccgt ggtgggccgc ggccgacgcg agcgcgacga accggccctg ccgaggctgc
     2221 gggcggcgca gcatggcggg gatcgcggcg cgcgcgaggt tggcgatccc ggtgacgccg
     2281 acggagaaca gggcgtccca ttcggtgtcg tcgctctccc acagcggacg gccgcccgcc
     2341 atgagcgcgg cggcggccac cgcggcgtcg agtccgccga agcgctcctc ggccagtgcg
     2401 accgccgagc gcagcccggc caggtcctgc acgtcggcga cgacgtcgag caccgagtcc
     2461 ggatacgagg ccgccagcgc ggccagctcc tccctggtgc cgagcgggta cggcacgcgg
     2521 gggtcgtcgg cgcagcggtc gacggccacc acctgccagc ccgtggtggc caggcgccgg
     2581 accaccgccg cgccgattcc ccgggcggca ccggtgacca gcgcgacgct cacaggtagc
     2641 ccttgccccg caggtactcc agcagctcgt cggccgcctc ggccgggtcg tcggtgacga
     2701 ctacgcgggg cggttcgcga tgctcgtgcg caccggtgag gcgcagcagc cgcagccggg
     2761 ggtcggcctc gggcggcggg ggaagctcct tggccctcgg ccggaacggg cgcgcggcgt
     2821 gtgcggtcac cggctcggcg gcgacggacc ccgtgacgac cgggatcgtg gccgtgcgcg
     2881 ccgccagtgt cgagggcagc gcggccctgc gcagccgcag cccggccggt tcgacggagc
     2941 acacggcggg cagcggcacg gcgagccgct ccctgcggcc cctgtcgagc ctgcgcagcg
     3001 ccagcagctc accgtcggca taggacagtt ccacgaggcc gagtgcctgc gcgcagccca
     3061 gctcggcggc gaggaacgcg ggggtgctgc cggtgccccg gtcggccgaa tggtcgccgg
     3121 tgagcacgag cgacggctcg ccgagttccg tcctgatcgc gtgtgcgagc gcccgcgccg
     3181 tggtggcgcc ggagtcgggg acgcgggagt cccacgacgg cacgtccacg cgcagcacgg
     3241 cgtcggcacc gcacgcgagg gcgtcgcgca gcagctcctc cgccggttcc ggggcgaggg
     3301 tcacggcgac gcaccggcct gcggcggcct cggcgatgcg cagtgcgtgc tccagcgcgc
     3361 acctgtcggc ctcgctcgga ccggcaccgc gcgggtcggt ctcgacctcg cccgatagcg
     3421 ggtcgatcct ggcccgcgcg tcggtccagc gcagcagggc cacgacgagc ggcctgagcg
     3481 gctcagccat ggcggaacac cacgccctgg ccgccgtcgg ggtagctcca gctgatcgcg
     3541 ttgccgccgt cgcacatcag gtaacacgtg ccgcactcga agcactgctc gtagttgaac
     3601 aggatcccgc cctcggcggt gggcacgaac aggttcgccg ggcacgcgtg cacgcaggtc
     3661 ttggtggtgc acgaccggca gacgtcggtg tccaccacga tgtgcggctg ctccgcgacc
     3721 cggaagtcaa cgtgcgacat ccggtcctcg aacgagacgt cgccgtaacg ctggttcatg
     3781 ggcacctcct agctgcagtg atggtggcct tcactgcgga tggttggctc atggggacac
     3841 tcctcacccg aacgaccgca ggccggtgag cgcgtccctg gccagctcgc gcatcttcac
     3901 gccgttgcgc ttcgccgacg cgcgcagcag cttccgcact cctggcttcg gcttggggtt
     3961 ctcgacggtg aacatcagct cgaccaggtc gcacaccagg ccggggtagc gctgctgaac
     4021 gcgctcggag agcaccagct ccggcgcctt gcgcagcttc ttgtggtcgg cgagcacgaa
     4081 cgacgactcc agcagacccc ggtactcgcg cagcgcgccg aggtcgcccg aggacagtgc
     4141 cttcgaagcc gccctgcccg cgtacatccc ggagcccatc gcgaagttca cgccctccag
     4201 ccagatcccg gccgcgaggc acatcgccgc cgcgtcgccc gccacgagca gcccgtcgcc
     4261 gacgagctgc ggcatcgtgt cgtagccgcc ctcggggatg aggtgtgccg agtactccac
     4321 cagctccgcg ccgcgcacga gcggctggat cgaagggtgc cgcttcagct cggcgagcac
     4381 ctcctcgggg cgcttcccgg acttcgcgag cccctgcagc ccgagcacga gcccgacgct
     4441 gagcgtgtcg gagttggtgt agaggaaccc accaccgggg atgccctgcg tgcagccgag
     4501 catctcgatg tcgacgccct cgtggccgct gacgccgaac cgttcgtcga tggtccgcgc
     4561 gggcagcgcg agcgtctcct tcacgccgag cgtggtgtgc gcggcctggt cgccggggaa
     4621 gagcccggcc tgcttggcga ggaacgagtt cacgccgtcg cacgcgatca cgaccttcgc
     4681 ggtgaggtcg ccgtccgggc ggtcggtgcg cacgccgacg atccggcccc gttccgtgcg
     4741 cagcaaccgg gtggccacgg tggacgggac gagcacggcg cccgccttct gcgcgtgccc
     4801 ggcgagccag tcgtcgaact cggcgcggta ggtcgtggcg ccgttgtagg gcgcgcgacc
     4861 ccagctctgg ctgcggaagt ccacggtcat cgagcgctcg ccgtccagca gcatggtctg
     4921 ccgccgcgtg acccagcgct gcaccggcat ctcgtcgtac cagccgggga tcagctcgtc
     4981 gaggatccgg ccgtagacca cgccgccgta gacgttcttc gagccgggaa acggcccgcg
     5041 ctccagcagc gccaccgaat gccccgcacg ggccagctcc agcgccgccg ccgagcccgc
     5101 ggggcccgcg ccgaccacga tcgcgtcgaa ctgcggccgc tccggctccg ccacggtcac
     5161 cgcggagctc gcgggtcctg ccctgtcacg catcgttgct cccgggggtg tccaggcggc
     5221 gagccagctc ccgcagcagc tcctgcgcgt cggtgaccag cccgaggtcg gccatcgccg
     5281 tcatgggcga gctgccgtcg gtgttcacgg acacgacgtg gcgcgggttg ccgagaccgc
     5341 cggtgtgctg ggtggcgccg gagaccccga acgccacgta cagatccgga tcgacgacca
     5401 cgcccgtggt gccgatctgc cgttcgtagg gcgcccagcc cgcgtcggtg accacgcgcg
     5461 tggcgccgac ggacgcgcca agcgccgagg cgacctcgcc gagcagcgcg agcgactccg
     5521 gcccggtcag cgcgcccctc gccaggccgg cgcccgcgcc gaggatgcgc ggggcctccg
     5581 cgaggtccgc ggtcgccggg tcgggatcga gcacctcgag cacgcgcgcg tcgggagatt
     5641 ccgggacgtc aaggtcgacg tgcgtgacct cgggcgtccc ctcggcgggg gcgctgccgc
     5701 gcacacccgg cacgagcgtc gcgacgaacg gccgcgacgt ctccacggtc accgagagcc
     5761 tgccgtccca gcgggcgagg tcggcgcact gctcaccgat ccgcaccgca ccggccagca
     5821 gcggccggtc cagctcggcg gcgaggcggg gcgcgaggtc cctgccgtcg gcggaggctg
     5881 gcagcacgac gcggcggacg tcgcgcaaca gcggcgcgag cgcgcccgcc cacgcccccg
     5941 cggcgaagtc accggcctcg gcacaccacg cgcgccgcag cggaggcagc tggtccgccg
     6001 cctgcgcgca gccggagccg acgagcagcg cgttcccgtc cgcctccgcc acggcctcgt
     6061 cgccgccgag cggggccaca ccacggcgga tcaccagcag ggcaagggaa tcggtgttca
     6121 caggaacgtt cacagcgcca ccgccacccg gtgtccctcg accacggcgg cgtgtgcgcg
     6181 gcggggggcc acgcagtcac ccgcgcggta cacctcgaac tcggccgagc cagagagctc
     6241 gtgccacagc tcgtcctccg gcgcctggtg cgtcgcgcac accacccagt cgcagcgcac
     6301 gtcggtggtt gatccggtgg tgtgcgtcag cacctgcagc cgcacaccac cggcgtcctc
     6361 ttcggcgccc aacaccacct cgtcggtggt ctgggtgatc cccttcgcgg cggcccgcac
     6421 gttgaaggtc tccatgtcca gcgtcacgcc gaggtcctgg ccgacgacca tgcccgacgt
     6481 cgagatccgc accgtgcagc cgcggtcggc gagcagctcg gccaccgagg tcgcctggtg
     6541 gaagccgagg tcgtcgatca ccacgacgtc gccctcgggc gcgacccggc cctccagcac
     6601 gtcccgcacg tcgacgatgc gctcgatccc gccggcccac cacggcgcct gcggcttcgc
     6661 gccggtcgcc agcaccacga cctccgggtt cagcgcgcgg atgtcgtcgg cggtcgccgt
     6721 gacgcccgtg cgcacgtcca cgccgtagcg gtggcactcc gagagcgagt tgcgcaccac
     6781 gtcgaggaac tcggcgcggc tcggcacgct cgcggccacg ctcgcctgcc cgcctgtcgt
     6841 ctggttccgc tccagcaacg tcacctcgtg cccgcgttcg gcggccgtcg ccgcggcctg
     6901 cagcccggcg ggcccaccgc ccaccaccac gacccggcgg ccccggcgcg tcggcatcgg
     6961 cagcgcgacg ctctccttgc cagtgcgcgg gttctcgatg cagcccagcc agcggttgag
     7021 gcccatgcgg ccgacgcact cctggttgca cgacaggcac gtgcggatct ccgtggcatg
     7081 tcccgcgcgg gccttggcga cgaagtcggc gtcggcgatc tgcccgcgca ccacgccgat
     7141 caggtcggcg tgcccctccg cgagcgcgcg gtcggcctgc aacgggtcct tgaaccggcc
     7201 gacacccacc accggcaggt ccaccgcctt gcgcagcgcg ctcgggatga acatcgcata
     7261 accgggcggg atgctcatcg acgcctcgat catgtacagg gtcgacgtgg cgaccccgat
     7321 cgaggtgttg atgtagtcca cgtgcccgct ggcctcgacc cacttggcga cctcgacggc
     7381 ctcgtcgatc gtggtgccgc cctcgatcag ctcgtcaccg cagagccgaa cgcccagcgc
     7441 cattcccggc ccgatcgcct cgcgcaccgc ggccacgagc cggagcagga tccgcgcgcg
     7501 gttctccagc gagccgccgt agtcgtcggt ccggacgttg gtggcggggg agaggaagcc
     7561 gcgcacgatc gaggagtgcg agcactgcaa ctcgacgccg tcgaacccac ccgcccggca
     7621 gtgctcggcg accttcgcgt acccggccac gatctcgtcg atctcggcga ccgtgacggc
     7681 cttcggcacc tcgcggaaca gcgggtcggg cacgggcgag ggcgcccaca ccggcagccg
     7741 cgagtacatg ctcgacgcct gcccgccgtt gtggttgagc tgcgcgaaga tcggcacgcc
     7801 gtgcgcgtgc accgcctcgg tgatgcgccg gtagccgggg atcacctcgg ggtggaagcc
     7861 gtggatgagc ttctcgtacg gccagtccgt cgggtgggtc gagtgctcct cggtgatgat
     7921 gagccccgcg ccgcccttcg cgcgggccgc gtagtaggcg gcgtgctgct cgctgggcag
     7981 cccttccttc gcgtagttgg tcaggtgcgc ggagaacacc acgcggttgg ccagtgtcac
     8041 cgggcccagc cgcagcggtg agaacaggta acggtaacgg ctcgttgcgc tcatcggtgc
     8101 accgccagtg gtttcgcggc gaaggccagc gcggccctgc ggccctccag tacggcctcg
     8161 tgcaccgatc gcggggccac gcggtcgccc gcctccacca tcccggccgg aaccggggtg
     8221 ggatcgggca gccggtgtcc acagtggatc agcgtggcgc actcgagctc ggtggctgtg
     8281 ccggtgtagg catcggtgac caccacgtga cccgcgtgca cctcgcgcag caggctccgc
     8341 ttggccagcc gcaccccggc ccgctgcagg cgcgcgttgg cgtcggcgag gtcgccggtg
     8401 agggcgagct gcgtgcccac cacctggtcc tgcgtgatga tcgtggtcgg cctgcccgcg
     8461 gcagcggcca gctcggcgat gcccacgccc acggcgtcgc ccaccgtgtc gtagatcgcg
     8521 accggcccct ccggcaggcg gccgggcgcc ttgagcaggt cgacgacgtc gagcacgaac
     8581 ccgccgtcgt gcacggtgta gctgcgcggt ccggcgaccg atccggtggc gaccacgacg
     8641 tcgccggaca gttccgcgag gtcggcctcg gtgttcagtg cgacctccac gccgagccgg
     8701 tgcacctcac cggcgagcca gcgcgcgagg ttgcccagcc ggtcgcggcc gggcacgcgg
     8761 gcggccagtg cgagcatccc gcccagctcg gcgtcccgtt cgaccagccg cacccggtgc
     8821 ccgcgcaggg cgagcacgcg cgcggcctcc agcccggccg gtccgccgcc gaccacgagc
     8881 acggaccgcg cgggatcggt tccggtcagc ggagcgtcgc cggtctcgtg cccgctgcgc
     8941 gggtcgccga tgcagctgac gatcgggttg cggttgtcgc ggacccggca cttctggttg
     9001 gtcagcgtgc acggccgcac gggctcggtc gtgccgagct tgcgcaccag gtccgcgtcc
     9061 gcgatctgcg cgcgcgtcat ctccacgagg tcggcgacgc cgtcggcgag cgcctgctcg
     9121 gcctgcccgg gttcgaccac cgaaccctgg aggatcacgg gcgccgcacc ggccaccgcc
     9181 tcgcggatgc cgcggcacag ctcgacgttg aagcccggct cggtgtgcga gtcggggcgc
     9241 gtggccgagg tgcccatcgc ggaaccgcgc accactacga gatagtcgac ctcgcgggcg
     9301 aggtccctgg cgagcgcctg cgcctggtcg ggcgtgatgc ccgcccacgg cgcgagctcg
     9361 tcgcaggaga gccgaaggcc gagcacgcgg ccgtcgccga tgcgggcgcg caccgctgcg
     9421 agcacctcgc gcagcagcag ggccttgtcg gtgccgtagg cgtcgccgcg ctggttggtc
     9481 agccccgaga ggaactgccg cagcagcgag tgctggccag cgtccacttc cacgccgtcg
     9541 aggtcggctt ccacggccag ctcggcggcg cgggtgaacc cggcgaccac cgcgcggatc
     9601 tcggccgcct ccatctccat cggcatctca cggctcgcca cgtccggcac ccgcgagggc
     9661 gcccacagcg cctgctgcga gaacgccgac gagccctgcg agcccgcgtg gccgaggccc
     9721 gcgagcacga gcgtcccgtg tggacggcag gcccgcacga ccgaggccca gccggcgccg
     9781 cagtcggcgg cgagcggggc ccgttcgtag ggccagtcgg agtcgtggac gctggccgtc
     9841 tcggtgacga tcagccccgc accgcccgcg gcacggcgct cgtagtaggc cacgtgggcc
     9901 tccgagatcg ccctgccgcg ggcgaggttc gtctcgtgtg gtccgaagag cacgcgcgac
     9961 ggtgcgcggc gaccggccag cgtgaccggt tcggtgagtt tcacggccgg aaacctgcca
    10021 gcgggctcgt gtcacacgcg cggtccggca ggcggtcggg ctctggtggg ccccacccga
    10081 tgctgacgcc gacgcggccg cgcttggtcc ggttgggctt ggagtggtcc ttgtccggct
    10141 tcggcttctc cgagccgccg ccgacgaggg cgagcgcgcg ctccccgttg cccttgacgc
    10201 attcgggatc gggaccgtcg agcggaaggc ccgtgaagaa cttggcggcc atgcagccgc
    10261 cctggcacga gtcgtaggcg gagcaggacg tgcacgcgcc gccggtctgc ggggcgcgca
    10321 gccgctcgaa cagctcggac gtgcgccaca ccgacgtgaa cccgccctcg tcgcgcacgt
    10381 tgcccgcgag gaactcgtcg tggatcgcga acgggcacgc gtacacgtcg ccgatcgggt
    10441 cgatcaagca caccacgcgc cccgcgccgc acaggttcag acccggcagc ggggtggagc
    10501 cgagcgcgtt gaggtggaag aacgagtcgc cggtgagcac gttctcaccg tggtcgatca
    10561 gccactcgta gagctcgagc tgctggtcgg ccgtggggtg cagctcgtcc cacgtgtcgg
    10621 cgccccggcc cgaaggccgc aggcgggtga tgcgcagctg cgccccgtag tcgtcggcga
    10681 tgcgcttgaa ctcgtcgagc tggccgacgt tgtggcgcgt catcaccacg ctgatcttga
    10741 agtccttgaa gcccgcgtcg cgcaggttct ccatggcccg catggtggtg tcgaacgacc
    10801 ccggcccgcg cacgtagtcg ttgacctcgg cggtggcgcc gtcgagggag agctgcacgt
    10861 cgacgtagtc ggtgccggcg agccagcggg ctcgctccgg ggtgatgcgc acgccgttgg
    10921 tggagaactt cacgcccacg tcgtgcgcga cggcgtagtc gaccagctcc cagaagtcgg
    10981 gccggatcgt gggctcgccg ccgccgatgt tgacgtagaa cacctgcagg cgctgcagtt
    11041 cgtcgatgac ggccttgcat tcctcagtgg acagttcacg agggtcgcgg cggcccgacg
    11101 aggaaaggca gtgcacgcag gagaggttgc aggcgtaggt cagctcccac gtgagacaga
    11161 tgggggcgtc cagcccgtgc tggaagtgct cgacgagttt catgaggtcc ctcttgcttc
    11221 gatcgtgccc gcggacagca gcccggcgag cgcgtcgaga tagcgcttgt gctcggcctc
    11281 gggtacctcg gctgagtcga gcgcggaacg agcgtcgggc tggttctcga gttcccggac
    11341 gacgttcacc agcagctgtg tcttgaggaa cgagagcttg cgggtggtga agtcgtagac
    11401 gagagcgccg aacggttccg gccgtaacgc gactgaggag ctcagccggt acggccggtc
    11461 cggggcgaac cgatcagtag acaccgcaca tgccgtcgat cgagacttct tcgacgagca
    11521 ggtcttcctc gacggtgacc tcggtggcgg ccgattcgtt catggcaagc tactcctcac
    11581 tgagcaggtt gttgtgatcg acggcacgag cataatggca ccgggtgcca aatggaaggg
    11641 atcggggcga aggcggtgtc ggaaccatcc gttcggccag gtagacgccg gtcgacgagt
    11701 cagcacgagc tggaggccgt ggccttcgag ctcttcgagc gcgaggggtt cgacgccacc
    11761 accgtcgacg cgatcgcgaa gagcgcgggc atcggcaggc gcacgttctt ccgctacttc
    11821 gagtcgaaga acgacgtggt gtgggggtcc ttcaccgagc agctcgacca catgcgcgag
    11881 cggttcgcgc aacgcccggc cgacgagccg ctcatggagt ccgtgcgcgc cgttgtggtg
    11941 gagttcaacc gcgtcgaccc cgccgaggtg cccaagcacc gcaggcgcat ggagctgatc
    12001 ctgcgcgtcc cggccctgca ggcccattcg acgctgcgct atggcgactg gcgcgccgtg
    12061 gtggccgagt acgccgcgaa acgcctcggc gagaagccgg ccgcgctgcg cccgcaggcg
    12121 atcgcctacg ccgcgctggg cgtctcgctc gcggcctacg agcactggct cgccgagacc
    12181 gatctgcagc tgtgtgacgt tctcgacgag gcgctgtccg agctggccag aggcttcgtg
    12241 ctgggctgaa cacgtttagc gatcgcccag acggggaccc tctccggcgt gaagaacatc
    12301 ttcgtactcg ccctcgacga ggagaacagg cgcaccctgc gcgacatccg gaacgcggac
    12361 tcctacgcgt tccactccct gctcacggtc gacgagacgc aggtagggga gatcgacttc
    12421 gaacagctgc tggacaaggc acagtcgcag ctggacgcct tcgacgggtc gatcgacgcc
    12481 atcgtgggct actgggattt cccggtgtcc acgttgcgcg cgatcctgtg ccaccgctac
    12541 ggcctccccg ggccgtcgct cgcgtcgatc gtcaaatgcg agcacaagta ctggagcagg
    12601 ctcgaacagc agaaggccat cgacgagtac ccgcgcttcg gcatcgtcga cctcgacgac
    12661 gagcaaccga gtccgccgga cggcgtgcgc tatccgatgt ggctcaagcc cgtgaagtcg
    12721 tactcctccg agctggcgtt cctcgtccgc gacgagtccg agttcgacaa ggccgtcgcc
    12781 gagatccgcg agggcatcag ccgcgtcggc aagcccttcg aacaggtgct ggacatgctg
    12841 gagctgccgc gtgagatcgc cgaggtgggc gggcaggctt gtctcgctga ggaggcgctc
    12901 tccggcgtgc agtgcgccac cgagggttac gtgtacaacg gcgaggtcgt ggtctacggc
    12961 gtgctcgact ccgtcaacta cgaaggccgt tcgtccttcc tgcggcacca gtacccatcg
    13021 cagctgccga aggccgccgt cgaccggatg atcgacgtct cgaagcgcat catcggtcag
    13081 atcgggatgg acaactcgac gttctccatc gagttcttct gcgagccgga gagcggcgac
    13141 gtgtgcctgc tggagatcaa cccgaggcac tcgcagtcgc acgccgagat gttcgaatgc
    13201 gtcgacggca tgcccaacca ccacgcgatg gtgatgctcg gcctcggccg ggaccccgcg
    13261 ctgcccgacg acaagggtga gtacggcatc gccgcgaagt ggtactaccg gcggttctcg
    13321 gacgcgctcg tgcggaaggt ccccaccgcg gaggagatcg agcgcgtgca ccgcgagatc
    13381 cccggcgtga tcatcgacat cgtgcccgtg gccggccagc ggctctccga cctgcccggc
    13441 caggacagct acagcttcga gctcgcgcac gtcttcgtcg gggcccgcga cgaaaccgag
    13501 ctgaaggaca agtacgagcg tacggtggag gcgctggact tcgagttcgc cgaggaaggg
    13561 cccgagaagg agggatagct tgctccgcgc ggtcggatcg ctgccgtgtc agaccacaga
    13621 ggacgaacac gtctggatcc ccgtctcgga cggcaccagg ctcgccgcca agatctggcg
    13681 gcccgtctcg tcggacgacc agccggtgcc ggggatcctg gagtacatcc cctaccgcaa
    13741 aagggacctc accgccgtcc gcgactcgat ccaccatcct tacctggccg ggcacggcta
    13801 cgcgtgcgtg cgcgtggaca ttcggggcac cggcgagtcg gagggcgtgc tgaccgacga
    13861 gtacctcgag ctggagcagc gcgacgccga ggacgtgctg gagtggatcg cgaaccagcc
    13921 gtggtgcgac ggccgcaccg gcatgatggg catctcctgg ggcggcttcg ccgcgctcca
    13981 ggtcgccgcc cgcaaaccgg agacgctgag ggcgatcgcg atcgcgtcgt tcaccgacga
    14041 ccgctattcc gacgacttcc actacatggg cggctgcctg ctctcggaca acctcgccga
    14101 ggcgggcacc atgttcgcgc acggcacgct gccgccggat ccggcgctcg tcggcgaccg
    14161 ctggcgcgac atgtggcgcg agcgcatcga ggcgagcggg ccgtgggtgg acacgtggct
    14221 gctgcaccag cgccgggacg actactggcg gcacgcgtcg gtgtgcgaga actactccgg
    14281 cgtgcgctgc cccgtgctcg cctccagcgg ctgggccgac ggctactcca acgccgtcgc
    14341 ccgcttgctc gcgaacctgg acgtgccgcg caaggggctc gtcggaccgt ggtcgcacaa
    14401 gtacccgcac ctcggcgagc cgggcccggc gatcggctac ctgcaggagc tcgtgcgctg
    14461 gtgggatcac tggctcaagg acgtcgacaa cgacgtcatg gacgggccca tgctgctcac
    14521 gtggatgcag gacagcgtgc cgccgtccac gtcctacgag gaccggcccg gccgctgggt
    14581 gggggagccg agctggccgt cgccgaacgt gcgggacgtc gagctgccgc tgtcccggca
    14641 ccgcatcggc aggccaggcg aggaggtggc cgacgagccg ctgaccgtgc agtcaccgct
    14701 gtcggtcggg cagttcgccg gtaagtgggc ctcctacaac gcgccgccgg acatgccgta
    14761 cgaccagcgt gaggaggacg gcgggtcgct cgtgttcgag accgacccgc tgccggagac
    14821 ctgcgagatc cacggcgcgc cgagggtctg cctcgagatc tcggccgacc agcccgtggc
    14881 gatggtggcc gcgcgccttt ccgacgtcct gcccgacggc agggccacgc gggtgaccta
    14941 cggcgtgctc aacctgaccc accgcgacgg gcacgacatc ccgaagccgc tggaacccgg
    15001 gaagcgctac caggtgagct tcgacctcaa cgtggtcgcg caggcgttcc cggcggggca
    15061 caagatccgg ctgtcgctgt cgtcgtcgta ctggccgctc gtgtggccgt cgccggagca
    15121 gacctgcctg accgttcaca ccggtgggag tggtgtgcgg ctgccgctgc gcacgggcgg
    15181 tgaggagcag gtgcaccgcc cgttcgccga gccggagggc gcggaaccga tcacggtgac
    15241 ccaggtggaa cccggcgagc accgctggac cgtcacccgc gacctcgtcg actacgagtc
    15301 ggcgctggag atcgtcaagg acaacggcac cgtccactac gaggacatcg acctcgacgt
    15361 cagcaggcgg gcctacgagc ggtacagctc ggtggcggac gacttctcgt ccccgcgcgc
    15421 ggagacggag tggacgatga ggttcgccag gggcgactgg tcggcgacca ccgtgacgcg
    15481 aacggtgctc acgtgcacca gcacggagtt ccgcctgcac gcgacgctgg acggctacga
    15541 gggcgagaag cgcctcttct cccgcaactg gcagcgcgcc atcccgaggg actgcgtgta
    15601 ggccctttcc aaccgcagtg aaggccacct tcactgcgtt caacgcaggt aaggtggcct
    15661 tcactgcagt ctggcggggg gtgccggggc tactggccga ccttgccgca ctcgccgttt
    15721 agcttgtgtt cggagaacgc gttggcgctg gccgactgga cggcgcgcag ggagctctgg
    15781 tccgagtgcg ctccgacgcc gggtgtctgg ccgatcgggt cggcgacgtc gccgagcggg
    15841 tggtgtgcga atgcggcctc gttggcgcag tcgaacgatt cgacaatggg atgaatcgtc
    15901 gccgatgcga taccggacat cagtccgaat gacaacgcga gcgccgcgaa aaacgcgaat
    15961 attcttttgc gcttcatcgg gggcctcccg ggtcttctcg gtggagaggc ctgccactat
    16021 ccacctgggc accggcgctt tcaagtgcgc gatattcacc cggcaattct tatcttctca
    16081 cgaattgccg ggtgcggcgg ttattcatga attgggtcgg cctgctgaaa ctctcgttcc
    16141 ggtcaggcgg gcagcttcag cttcaggatc tccgcggaga cctcgcccgc cggggtgcgg
    16201 taggtgatcg tgtcgccctt cttgtgcccc gttatggccc tgccgagcgg gctgtcggcg
    16261 gtgagcgtgg acgcgtcgtc ctcgtcggcc tcctcggtga agccgaccac caccatgtcc
    16321 tccacgctgc cgtcgctgaa cttcagcgag accttcgtgc ccgagggcag cgcggactcg
    16381 gagtcggcgg tggggccgcc gtggagcagg tcgtacacct cggcgatccg gcggtccagc
    16441 cgcgacacga cctcggcccg ctcgagcagg tcggcctggt cggcactgtc gcccagcggg
    16501 tcctcgccga gccgtggcgc cagggactcg cgctgttcgc gtagggattc gagctccttc
    16561 tcgagccgcg cgcgggtggc cgggctcaag cctccggtgg acgtcattga cccattgtcg
    16621 ggcttgaccg cccggcccgc cacgtcattc accgaggtca cccccggcgg cgacctcgtc
    16681 agcgaccgta accggccttg cgcagggcgt ccgccatcgc gccgccggcg ggcgcctggc
    16741 gctgcctgcc ctggccctgc cgctgctgct gcggcttgcc accgcggccg cgctgacctc
    16801 cacgcccgcc gccctggccg gactggcgct gttccccgcc accgggcttg gcctcgtcgt
    16861 cgagccgcag cgtcagcgag atccgcttgc gcgcaacgtc cacctcgagc accttcaccc
    16921 gcacgacgtc acccggcttg accacctcgc gcgggtcctt gacgaagttg cgcgacatcg
    16981 ccgacacgtg tacgaggccg tcctggtgca cgccgatgtc gacgaaggcg ccgaacgccg
    17041 cgacgttggt gaccacgccc tccagccgca tccccggcgt caggtcggtc atcttctcca
    17101 cgccctcggc gaaggtcgcc gtcttgaact cgggccgggg gtcgcggccg ggcttctcca
    17161 gctcggcgag gatgtcggtg accgtcggca ggccgaacgt gtcgtcgacg aacttctccg
    17221 gctggagcgc ccgcagcgtg cgcgcgtcgc cgatcagctc ccggatgccg acgttcgtct
    17281 cgtccaggat ccggcgcacc accgggtacg cctcggggtg cacgctggag gcgtcgagcg
    17341 ggtcgtcgcc gtccgggatc cgcaggaagc cggcgcactg ctcgaacgcc ttcgggccga
    17401 gccgggcgac ctccttgagc gcggtcctgc tgcggaacgg cccgttgtcg tcccggtgcg
    17461 ccacgatgtt ctcggcgagc gtcgtcccga tgcccgacac ccggctgagc aggggcaccg
    17521 aggcggtgtt gaggtccacg cccacggcgt tcacgcagtc ctccaccacc gcgtcgagcg
    17581 aacgcgagag cttcgactcg gcgaggtcgt gctggtactg cccgacgccg atcgacttcg
    17641 ggtcgatctt caccagctcg gccagcggat cctggagcct gcgcgcgatc gacaccgcgc
    17701 cgcgcagcga gacgtccagt cccggcagct cctgtgccgc gtacgccgac gccgagtaca
    17761 ccgaggcgcc cgcctcggag accacgatct tggtgagctt cagctcgggc cgcagcttca
    17821 ccagctcgcc cgcgagcttg tcggtctcgc gcgaggccgt gccgttgccg atggcgatga
    17881 gctgcacgtt gtgctcgcgc gcgaggtgct ccagcttcgc cagcgactgg tcccactgcg
    17941 actgcggctt gtgcgggtag atcgtgtcgg tggccaccac cttgccggtg ccgtcgacga
    18001 tcgccacctt cacgcccgtg cggtagccgg ggtcgagacc catcgtcgtg cgcgtgccgg
    18061 cgggcgcggc gagcagcagg tcacgcaggt tcgcggcgaa cacgcgcacg gcctcgtcct
    18121 cggcggcctg ccgcaggcgc atccgcaggt cgatgccgag gtgcagcagg atcttcgtgc
    18181 gccacgccca ccgcacggtg tcgttgagcc acttgtcgcc cgcgcggccc tggtcggaga
    18241 tgccgaactt ctcggcgatc cggatctcgt agtcgctcgg gccccgcttc ggctcggcat
    18301 cgggagccgg gggctcctcc ggctcggtgg ccacgtcgag gatctcctcc ttctcgccgc
    18361 ggaacagggc gaggatgcgg tgggagggga gcttcgtgaa cggctcggcg aagtcgaagt
    18421 agtcggagaa cttcgcgcct tcggtctcct tgccctggcg gaccttcgag gtcacccagc
    18481 cgcgcgtcca catgcgctcg cgcagctcgc cgatcaggtc ggcgtcctcg gcgaagcgtt
    18541 ccaccaggat ggccttggcg ccgtccagcg cggcggcggc gtcggcgacg cccttctccg
    18601 gatcgacgaa cacggcggcc gcggcctgcg gctcggtggt cgggtcggag agcaggccgt
    18661 cggccagcgg ctccagcccg gcctccttgg cgatctgcgc cttggtgcgc cgcttcggct
    18721 tgtacggcag atagatgtcc tcgaggcggg ccttctcctc ggcagccatg atgcgggcct
    18781 cgagctcggc gtcgagcttg ccctgcgagc ggatcgactc caggatcgtc gttcgccgct
    18841 cctccagctc acgcaggtaa cgcagccggt cctcgagcgt gcgcagctgc gtgtcgtcga
    18901 gcgccccggt cacctccttg cggtaccggg cgatgaacgg cacggtcgag ccctcgtcga
    18961 gcagggtgac ggcggcccgg acctgtccct cgcggacacc gagctcgtcg gcgatcttct
    19021 gatgaatcga caccttctca gccacgttgg gcattgtgcc ctgtctgtat tgaggcatca
    19081 tcggcccatg gccgactacg acatcaagcc gcgcagcagg gccgtcaccg acgggatcga
    19141 acgcgccgcc gcacgcggga tgctgcgggc cgtcgggatg ggcgacgagg acttcgccaa
    19201 gccccagatc ggcatcgcgt cctcgtggaa cgagatcacc ccgtgcaacc tctcgctgca
    19261 gcggctcgcc gaggcgagca agaagggtgt gcacgccggc ggcgggttcg ccatggagtt
    19321 cggcacgatc tcggtctcgg acggcatctc catgggacac gagggcatgc acttctcgct
    19381 cgtgtcccgt gaggtcatcg cagactcggt ggagaccgtg atggaggcgg agcggctcga
    19441 cggcgccgtg ctgctcgccg ggtgcgacaa gagccttccg ggcatgctga tggccgcggc
    19501 caggctcgac gtggcggcgg tgttcctcta cgcgggttcg accctgcccg gcacggtcga
    19561 cggccgcgag gtgacgatca tcgacgcgtt cgaggcggtc ggcgcgtgcg cgcgcgggct
    19621 catgacccgc gaggaggtcg acaagatcga gcgcgccatc tgccccggcg agggcgcgtg
    19681 cggcggcatg tacacggcca acaccatggc ctgcgtgtcg gaggcgctcg gcatgtcgct
    19741 gcccggctcg gccagcccgc cctcggtcga ccgccgccgc gacgggttcg cgcgcgccag
    19801 cggcgaggcg gtggtggagc tgctgcgcaa gggcatcacc gcgcgcgaca tcctcacccg
    19861 cgaggcgttc gagaacgcga tcgccgtggt catggcgctc ggcgggtcca ccaacgccgt
    19921 gctgcacctg ctcgcgatcg ccaacgaggc gcaggtggag ctcaccctcg acgacttctc
    19981 ccggatcggc gatcgcgtgc cccacctcgc cgacgtcaag ccgttcggca ggcacgtgat
    20041 gacggccgtc gaccgcgtgg gcggcgtgcc cgtggtgctg aaggccctgc tcgacgcggg
    20101 tctcgtgcac ggcgactgcc tcaccgtcac gggccggacg ctcgcggaga acctcgccga
    20161 gctcggcccg cccgagctcg acggcgaggt gctgcgcaag ctcagcgacc cgatccaccc
    20221 cacgggcggc ctgacgatcc tgcacggcag cctcgcgccc gagggcgccg tcgtgaagag
    20281 cgcgggcttc gacgccagcc ggttcgaggg cacggcgcgc gtcttcgacg gagaacaggc
    20341 cgcgatggac gcgctcggcg agctgaaggc gggcgatgtc gtggtgatcc gcaacgaggg
    20401 cccgcgcggc gggcccggca tgcgcgagat gctcgccgtc accggcgcga tcaagggcgc
    20461 gggactcggc aaggacgtcc tgctgctcac cgacggccgg ttctccggcg gcaccacggg
    20521 cctgtgcatc ggacatgtcg cgccggaggc cgcgcacggc gggccgatcg cgttcgtcga
    20581 ggacggcgac ccgatcgtac tcgacctggc cgcgcgcacg ctcgacgtcg ggatcgacga
    20641 ggccgagctg gcgcggcgcc gtgagggctg ggaacagcct ccgccgccgc ggcgcaccgg
    20701 cgtgctcgcc aagtacgcca agctcgtcgg ttcggcggca cagggcgcgg tgtgctcgtg
    20761 acccgcaccg cgctcgtcac cggcggcacc gggggcctgg gcgtcgccgt gacgagagcg
    20821 ctcctcggtg acggctggcg cgtggtggtg ccgtggatca ccgaggcgga gctggagcgg
    20881 ctggagccca ccgaggggct cgaactggtg cgcgccgatc tcttcgaggc cgcagacgcg
    20941 cggcgctgcg ccgagcaggc ggccggcgtg acgcgggcgc cgttgcgggc ggtggtgaac
    21001 ctcgtcggcg ggttcgcgat gggggagcgg gtggccgaga cgcccgtgga ggacttcgag
    21061 cagcagttgc ggctcaacct gcgccccacg tacctcgtgt cgcaggcggc ggtgccgcac
    21121 ctgatcgagg cgggcggcgg ggcgatcgtg tgcatgtcca gcagggccgc gctgcacccg
    21181 ttccccggtg cggccgggta cgtgacctcc aaggccgccg tgctgggcct ggttggcgcg
    21241 ctggacgcgg agtactcgcg acgcggcatc cgcgtcaacg cggtcttgcc gagcatgatc
    21301 gacaccccgg cgaaccgggc gagccagccc ggggccgacc ggtctcgctg ggtctcaccg
    21361 gaacgcatcg cgaaggtgat cgccttcctg tgcggggacg acgcgggcgt ggtgagcgga
    21421 gcccacgtcc cggtctacgg ctgacgccgc ccgcgagtcc cccgctccgg cccgcgagtc
    21481 cccc
//
