LOCUS       NZ_CP039297            23042 bp    DNA     circular CON 11-MAY-2024
DEFINITION  Bacillus velezensis isolate UFLA258 chromosome, complete genome.
ACCESSION   NZ_CP039297
VERSION     NZ_CP039297.1
KEYWORDS    RefSeq.
SOURCE      Bacillus velezensis
  ORGANISM  Bacillus velezensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus amyloliquefaciens group.
REFERENCE   1  (bases 1 to 3947206)
  AUTHORS   Silva,F.J., Ferreira,L.C., Souza,J.T., Campos,V.P. and Barros,A.F.
  TITLE     Bacillus velezensis Bv258 complete genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3947206)
  AUTHORS   Silva,F.J., Ferreira,L.C., Souza,J.T., Campos,V.P. and Barros,A.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2019) Department of Phytopathology, Federal
            University of Lavras, Campus Universitario, Lavras 3037, Brazil
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 17-SEP-2018
            Assembly Method                   :: SPAdes v. 2018-09-17
            Assembly Name                     :: Bv_UFLA258
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 849.0x
            Sequencing Technology             :: Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004799565.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 04:05:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,891
            CDSs (total)                      :: 3,775
            Genes (coding)                    :: 3,712
            CDSs (with protein)               :: 3,712
            Genes (RNA)                       :: 116
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 33 of 63
            Pseudo Genes (incomplete)         :: 41 of 63
            Pseudo Genes (internal stop)      :: 6 of 63
            Pseudo Genes (multiple problems)  :: 15 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:23:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 97329
            Orig. end                         :: 120371
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP039297.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Laboratory of bacteriology
            at the Federal University of Lavras.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23042
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23042
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23042
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13042](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13042
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     CDS             717..791
                     /gene="allorf_0098046_0098120"
                     /locus_tag="allorf_0098046_0098120"
                     /protein_id="allorf_0098046_0098120"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTGARTSGGACGLIRSNAKNLTRS"
     CDS_motif       717..746
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTGARTSGGA"
                     /locus_tag="allorf_0098046_0098120_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       747..791
                     /prepeptide="core"
                     /locus_tag="allorf_0098046_0098120_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="1478.7"
                     /monoisotopic_mass="1477.8"
                     /core_sequence="CGLIRSNAKNLTRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTGARTSGGA"
                     /leader_location="[716:746](+)"
                     /alternative_weights="1496.7"
                     /alternative_weights="1514.7"
     misc_feature    complement(819..828)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.98"
                     /tool="antismash"
     CDS             950..1012
                     /gene="allorf_0098279_0098341"
                     /locus_tag="allorf_0098279_0098341"
                     /protein_id="allorf_0098279_0098341"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTAGDKPEEGGDDVKSSCPL"
     CDS_motif       950..982
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTAGDKPEEGG"
                     /locus_tag="allorf_0098279_0098341_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       983..1012
                     /prepeptide="core"
                     /locus_tag="allorf_0098279_0098341_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.50"
                     /molecular_weight="927.0"
                     /monoisotopic_mass="926.4"
                     /core_sequence="DDVKSSCPL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAGDKPEEGG"
                     /leader_location="[949:982](+)"
                     /alternative_weights="945.0"
     CDS             complement(1093..1332)
                     /gene="allorf_0098422_0098661"
                     /locus_tag="allorf_0098422_0098661"
                     /protein_id="allorf_0098422_0098661"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIQPHLPIRLPCYDFTPIICPTFGGWLLKGYLTDFGCYKLSWCDG
                     RCVQGPGTYSPRHADPRLLAIPASRSRVADCDPN"
     CDS_motif       complement(1126..1332)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MIQPHLPIRLPCYDFTPIICPTFGGWLLKGYLTDFGCYKLSWCDGRCVQGPGTYSPRHA
                     DPRLLAIPAS"
                     /locus_tag="allorf_0098422_0098661_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(1093..1125)
                     /prepeptide="core"
                     /locus_tag="allorf_0098422_0098661_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.90"
                     /molecular_weight="1114.2"
                     /monoisotopic_mass="1113.5"
                     /core_sequence="RSRVADCDPN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIQPHLPIRLPCYDFTPIICPTFGGWLLKGYLTDFGCYKLS
                     WCDGRCVQGPGTYSPRHADPRLLAIPAS"
                     /leader_location="[1125:1332](-)"
     rRNA            1573..4502
                     /db_xref="RFAM:RF02541"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="E4T61_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="E4T61_00540"
                     /product="23S ribosomal RNA"
     gene            1573..4502
                     /locus_tag="E4T61_RS00540"
                     /old_locus_tag="E4T61_00540"
     CDS             1596..1712
                     /gene="allorf_0098925_0099041"
                     /locus_tag="allorf_0098925_0099041"
                     /protein_id="allorf_0098925_0099041"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MDALALGADEGRDEHRYASGSCKQALIRRFPNGETHHS"
     CDS_motif       1596..1649
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDALALGADEGRDEHRYA"
                     /locus_tag="allorf_0098925_0099041_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1650..1712
                     /prepeptide="core"
                     /locus_tag="allorf_0098925_0099041_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.20"
                     /molecular_weight="2153.4"
                     /monoisotopic_mass="2152.1"
                     /core_sequence="SGSCKQALIRRFPNGETHHS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDALALGADEGRDEHRYA"
                     /leader_location="[1595:1649](+)"
                     /alternative_weights="2171.4"
                     /alternative_weights="2189.4"
                     /alternative_weights="2207.4"
     CDS             complement(2637..2771)
                     /gene="allorf_0099966_0100100"
                     /locus_tag="allorf_0099966_0100100"
                     /protein_id="allorf_0099966_0100100"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIRLAPVHFRRRVTRPVSYYALFKWWLLLSQHPGCLSNSTSFST"
     CDS_motif       complement(2709..2771)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIRLAPVHFRRRVTRPVSYYA"
                     /locus_tag="allorf_0099966_0100100_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2637..2708)
                     /prepeptide="core"
                     /locus_tag="allorf_0099966_0100100_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="2526.9"
                     /monoisotopic_mass="2525.3"
                     /core_sequence="LFKWWLLLSQHPGCLSNSTSFST"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIRLAPVHFRRRVTRPVSYYA"
                     /leader_location="[2708:2771](-)"
                     /alternative_weights="2544.9"
                     /alternative_weights="2562.9"
                     /alternative_weights="2580.9"
                     /alternative_weights="2599.0"
                     /alternative_weights="2617.0"
                     /alternative_weights="2635.0"
     CDS             3831..3992
                     /gene="allorf_0101160_0101321"
                     /locus_tag="allorf_0101160_0101321"
                     /protein_id="allorf_0101160_0101321"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSGGQFDWGGRLLKGNGGAQRFPQNGWKSFAECKGTRELDCETYK
                     SSRDESRA"
     CDS_motif       3831..3884
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSGGQFDWGGRLLKGNGG"
                     /locus_tag="allorf_0101160_0101321_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       3885..3992
                     /prepeptide="core"
                     /locus_tag="allorf_0101160_0101321_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="3974.3"
                     /monoisotopic_mass="3971.9"
                     /core_sequence="AQRFPQNGWKSFAECKGTRELDCETYKSSRDESRA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSGGQFDWGGRLLKGNGG"
                     /leader_location="[3830:3884](+)"
                     /alternative_weights="3992.3"
                     /alternative_weights="4010.3"
                     /alternative_weights="4028.3"
                     /alternative_weights="4046.4"
     CDS             4095..4325
                     /gene="allorf_0101424_0101654"
                     /locus_tag="allorf_0101424_0101654"
                     /protein_id="allorf_0101424_0101654"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAPRCRLIASWGCSRSQGLGCSPIKAVRELGSERRETVRSLSVAG
                     AGNLRGAVLSTRGPGWTHRWCTSCSAKGIAG"
     CDS_motif       4095..4232
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAPRCRLIASWGCSRSQGLGCSPIKAVRELGSERRETVRSLSVAGA"
                     /locus_tag="allorf_0101424_0101654_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4233..4325
                     /prepeptide="core"
                     /locus_tag="allorf_0101424_0101654_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.30"
                     /molecular_weight="2992.4"
                     /monoisotopic_mass="2990.5"
                     /core_sequence="GNLRGAVLSTRGPGWTHRWCTSCSAKGIAG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAPRCRLIASWGCSRSQGLGCSPIKAVRELGSERRETVRSL
                     SVAGA"
                     /leader_location="[4094:4232](+)"
                     /alternative_weights="3010.4"
                     /alternative_weights="3028.4"
                     /alternative_weights="3046.4"
                     /alternative_weights="3064.5"
     CDS             complement(4255..4401)
                     /gene="allorf_0101584_0101730"
                     /locus_tag="allorf_0101584_0101730"
                     /protein_id="allorf_0101584_0101730"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRNGKSHLEGGFMLRCFQHLSRPHIATQRCPWQNNWYTSGASIPV
                     LSY"
     CDS_motif       complement(4369..4401)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRNGKSHLEGG"
                     /locus_tag="allorf_0101584_0101730_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4255..4368)
                     /prepeptide="core"
                     /locus_tag="allorf_0101584_0101730_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.00"
                     /molecular_weight="4301.9"
                     /monoisotopic_mass="4299.1"
                     /core_sequence="FMLRCFQHLSRPHIATQRCPWQNNWYTSGASIPVLSY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRNGKSHLEGG"
                     /leader_location="[4368:4401](-)"
                     /alternative_weights="4319.9"
                     /alternative_weights="4337.9"
                     /alternative_weights="4356.0"
                     /alternative_weights="4374.0"
     CDS             4508..4735
                     /gene="allorf_0101837_0102064"
                     /locus_tag="allorf_0101837_0102064"
                     /protein_id="allorf_0101837_0102064"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MYAYCYLVLREHSQWFGGDSEEVTPVPMPNTEVKLFSADGSRGFP
                     PVRVGRRQAIITVKAAHHELPFLCFSAYVI"
     CDS_motif       4508..4561
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MYAYCYLVLREHSQWFGG"
                     /locus_tag="allorf_0101837_0102064_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4562..4735
                     /prepeptide="core"
                     /locus_tag="allorf_0101837_0102064_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="6156.0"
                     /monoisotopic_mass="6152.3"
                     /core_sequence="DSEEVTPVPMPNTEVKLFSADGSRGFPPVRVGRRQAIITVKAA
                     HHELPFLCFSAYVI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MYAYCYLVLREHSQWFGG"
                     /leader_location="[4507:4561](+)"
                     /alternative_weights="6174.0"
                     /alternative_weights="6192.1"
                     /alternative_weights="6210.1"
                     /alternative_weights="6228.1"
                     /alternative_weights="6246.1"
                     /alternative_weights="6264.1"
     rRNA            4553..4668
                     /db_xref="RFAM:RF00001"
                     /gene="rrf"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="E4T61_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="E4T61_00545"
                     /product="5S ribosomal RNA"
     gene            4553..4668
                     /gene="rrf"
                     /locus_tag="E4T61_RS00545"
                     /old_locus_tag="E4T61_00545"
     CDS             4695..4895
                     /gene="allorf_0102024_0102224"
                     /locus_tag="allorf_0102024_0102224"
                     /protein_id="allorf_0102024_0102224"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSCLFCVFLHTLYNMRNVTICLFAKAGFMLVQSGNNRDRAIQLKN
                     FAKHLIVRLKSNIVKVNKGGG"
     CDS_motif       4695..4739
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSCLFCVFLHTLYNM"
                     /locus_tag="allorf_0102024_0102224_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4740..4895
                     /prepeptide="core"
                     /locus_tag="allorf_0102024_0102224_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.60"
                     /molecular_weight="5585.6"
                     /monoisotopic_mass="5582.2"
                     /core_sequence="RNVTICLFAKAGFMLVQSGNNRDRAIQLKNFAKHLIVRLKSNI
                     VKVNKGGG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSCLFCVFLHTLYNM"
                     /leader_location="[4694:4739](+)"
                     /alternative_weights="5603.6"
                     /alternative_weights="5621.6"
     misc_feature    complement(4720..4738)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.02"
                     /tool="antismash"
     gene            4896..5360
                     /gene="ctsR"
                     /locus_tag="E4T61_RS00550"
                     /old_locus_tag="E4T61_00550"
     CDS             4896..5360
                     /codon_start=1
                     /gene="ctsR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_387964.1"
                     /locus_tag="E4T61_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00550"
                     /product="transcriptional regulator CtsR"
                     /protein_id="WP_003156396.1"
                     /transl_table=11
                     /translation="MGHNISDIIEQYLKQVLDQNGKEILEIKRSEIADKFQCVPSQINY
                     VINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQIHTHLSQAASDDIIL
                     RLLEDGVISEREAKMMVSVMDRSVLYIDLPERDELRARMMKAMLTSLKLK"
     gene            5374..5931
                     /locus_tag="E4T61_RS00555"
                     /old_locus_tag="E4T61_00555"
     CDS             5374..5931
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003156397.1"
                     /locus_tag="E4T61_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00555"
                     /product="UvrB/UvrC motif-containing protein"
                     /protein_id="WP_007410387.1"
                     /transl_table=11
                     /translation="MICQECNERPATFHFTKVVNGEKQEVHICEQCAKENSDSYSISGN
                     QGFSIHNLLSGLLNMESSFQNTGSQMFGYSEQGTACKKCGMTFQQLRKTGRFGCAECYD
                     TFYSQITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQMEMLKKELESLIHHEEFERAAE
                     VRDQIRSLEQKLKSKDSEGEQG"
     gene            5931..7022
                     /locus_tag="E4T61_RS00560"
                     /old_locus_tag="E4T61_00560"
     CDS             5931..7022
                     /EC_number="2.7.14.1"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0046314 - phosphocreatine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_387966.1"
                     /locus_tag="E4T61_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00560"
                     /product="protein arginine kinase"
                     /protein_id="WP_003156398.1"
                     /transl_table=11
                     /translation="MSLKHFIQDALSNWMKQKGPESDIVLSSRIRLARNFENIKFPARY
                     TNEEASSIIQQFEDHFSGKELPDIGQFHLIRMSEAQPLEKRVLMEKHLISPNLTESPFG
                     GCLLSENEEVSIMLNEEDHIRIQCLFPGFQLLNAIKAANQVDDWIEEKVDYAFGEKRGY
                     LTSCPTNVGTGLRASVMMHLPGLVLTRQMNRIIPAINQLGLVVRGIYGEGSEALGNIFQ
                     ISNQITLGKSEQDIVDDLNSVAAQLIEQERSAREALYQTSKIELEDRVFRSYGVLSNCR
                     MIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRPNERDAR
                     RAALIRERLHLEMSANRQEDDSI"
     gene            7019..9457
                     /gene="clpC"
                     /gene_synonym="mecB"
                     /locus_tag="E4T61_RS00565"
                     /old_locus_tag="E4T61_00565"
     CDS             7019..9457
                     /codon_start=1
                     /gene="clpC"
                     /gene_functions="other (smcogs) SMCOG1223: ATPase"
                     /gene_kind="other"
                     /gene_synonym="mecB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_387967.1"
                     /locus_tag="E4T61_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00565"
                     /product="ATP-dependent protease ATP-binding subunit ClpC"
                     /protein_id="WP_132107346.1"
                     /transl_table=11
                     /translation="MMFGRFTERAQKVLALAQEEALRLGHTNIGTEHILLGLVREGEGI
                     AFKALEALGLNSDKMQKEVESLIGRGQESTTSVPHYTPRAKKVIELSMDEARKLGHSYV
                     GTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSASGTNSNANTPT
                     LDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGL
                     AQQVINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDE
                     LHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQV
                     DQPSADESIQILKGLRDRYEAHHRVSITDEAIEAAVKLSDRYISDRFLPDKAIDLIDEA
                     GSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTK
                     KTWKEKQGQENSEVSVEDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEA
                     VVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDEEAMIRVDMS
                     EYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVL
                     EDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDESQNHKDMKDKVMGEL
                     KRAFRPEFINRIDEIIVFHSLEKKHLTDIVSLMSDQLTKRLKEQDLSIELTDAAKAKVA
                     EEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIDKGQHIVLDVEDGEFVVKTTAKTDA
                     "
     misc_feature    9631..9645
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.3"
                     /tool="antismash"
     gene            9708..9944
                     /locus_tag="E4T61_RS00570"
                     /old_locus_tag="E4T61_00570"
     CDS             9708..9944
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="E4T61_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00570"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_052826974.1"
                     /transl_table=11
                     /translation="MSEKQIERTIRAWKDPEFRKTLSDVADHPSGSIEARQLSMLGSEE
                     NVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV"
     CDS_motif       9708..9836
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSEKQIERTIRAWKDPEFRKTLSDVADHPSGSIEARQLSMLGS"
                     /locus_tag="E4T61_RS00570_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9837..9944
                     /prepeptide="core"
                     /locus_tag="E4T61_RS00570_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.30"
                     /molecular_weight="3718.5"
                     /monoisotopic_mass="3716.1"
                     /core_sequence="EENVNPMTTPVSPAPTVVIRVSLKVCPTFKIKCKV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEKQIERTIRAWKDPEFRKTLSDVADHPSGSIEARQLSML
                     GS"
                     /leader_location="[9707:9836](+)"
                     /alternative_weights="3736.5"
                     /alternative_weights="3754.5"
                     /alternative_weights="3772.5"
                     /alternative_weights="3790.6"
     gene            10001..13042
                     /locus_tag="E4T61_RS00575"
                     /old_locus_tag="E4T61_00575"
     CDS             10001..13042
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="E4T61_RS00575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00575"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_132107344.1"
                     /sec_met_domain="DUF4135 (E-value: 6e-106, bitscore: 352.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.5e-56, bitscore:
                     186.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNLFDEFKNGSYISERIPDRGTKIIHDQYEKWVLTSGLKKEVFE
                     EKIEKYYKGFNIFSKVISSGCDFEISDRLWIDRLNEIFKETYKYNGNHSYKQSVFYYFN
                     YPFLDWALRKIDFEFSHIFDYSYINAVKLRDSLINAIQENLDSLVSRTLILDLNIERLK
                     GNLVGKTSDERYHSYSKKFLESPKEILKVLKEYSVLARLIVSSVEKNINNFKETLSRYI
                     SDRRDLIEKKFISDSVLVSLEKGLGDDHNNGRSIMCLKFDNGHKLIYKPRSLHMDKKFE
                     ELITWINQKKFQPELKYAKSIDKKSYGWQKFINYRACNKEKDIELFYERQGAYTALLYI
                     LNATDFHLENMIAHSAYPILVDLESLFQNKIEHKSYNIVDELAWDKINNSVILTGMLPV
                     SNYTGVEFDLSGIGGNGNQELPFESFDFQNVGTDNMKLVKTKQEYKGSQNQPLTSNDAI
                     QPSKYIESIIKGFTSLYNLFKENKRELLDEDGPIEAFKDVYFRFIYRNTATYAEFLEWS
                     LHPDYLMNGLDRNLLFENIWNKKHLQNLDIIFSEYNDLLNHDIPYFYAGINSKDLITSR
                     GERISSFFEKESLTIVKERIKQLSTMDYKQQIEFIRQCFSNLSETQSNLKYSENFEKSV
                     DKTLAELIGDFLISKSIIDVNNNFVTFISKKQIDSEKFILSPIDESLYEGVLGVGLFFL
                     YLNRQYNKDEYKNMALRCINSAKIKINENENISAFYGLCSYLYVLNHYIYFFPEKKREF
                     AEDIKMVLNKLDSFKHNYNNEIDFIGGYAGAIIVLLNIYCTLRIEDALSLAKSFGSFVL
                     EYIDSSVEKDEFKMLTGISHGASGIALALKKLEDVTGDKIYEDYINMLIEYEDYHYSRE
                     KKNWRDLRNINNEYQNFWCHGAPGILLARSNMNRNFDGAEQKIIIDKLLSRKYNDITLC
                     HGKLGVQLIILELAKKQNNQTLIHLVSDSIEEIERSLNSDRIKQKFELDFGLMTGAAGV
                     GYALLYGNDFLGMPNILTLEQPIL"
     gene            13091..14809
                     /locus_tag="E4T61_RS00580"
                     /old_locus_tag="E4T61_00580"
     CDS             13091..14809
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="E4T61_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00580"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_052826976.1"
                     /transl_table=11
                     /translation="MKQVYKLLKVIELPKYVLMICLLLSLLETAFSLSIPLLTRELVDS
                     FSKGLDFTKIIVLTLVLLFQTFLSGILLYLLNRIGQKVVKSIRVKGIEKIFTFNMGFFE
                     KNKSGDIISKITNDTLIIKDFFGSDLISFISGIIAVIGSVIILIVLDWRLTLVLIISIP
                     LISLFLLPMGGKVLSISQRQQHYVGSLTSFLNRVLDNIKLIKISNTESLEEKKGIENAT
                     HIYRESIKEAKIFSILTPLISLVLMLIIVSIIMYGGYRVSSHTLTSGDLMAFIMYLIQI
                     IIPVSSIGEFFVTYKKSLGAINRVNDLIFNKEVEKKEGLKYSEPNTNILFKNVSFSYNE
                     EKETLKDISFSLKPGTVTALVGPSGAGKTTIFSLLERLYEPKSGGIFLNNKLISEYELQ
                     EWRKQIGYVTQETPIIDGTILDNILYGTKGDFTKEQIDSVLERTYLKKDVGGFSKGIYT
                     EVGEKGMKLSAGQRQRIAIARVILRDPKLLLLDEATSNLDSYSEEIIKKTLDYLMGEKT
                     SLVIAHRLSTILSADNIIILENGRVSGSGTHKDLYEMHPLYKRLVDIQFDLSEVK"
     gene            14815..15852
                     /locus_tag="E4T61_RS00585"
                     /old_locus_tag="E4T61_00585"
     CDS             14815..15852
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="E4T61_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00585"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_052826977.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.1e-37, bitscore:
                     126.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLELIQNADLYQKWGWAVDLVTDNGKTFYSEKGSQDVKIAIID
                     SGIDTDHPDLKENILLEKAMSFIDDSIDDKIGHGTQIAGIIAANGRLLGIGPELKIIPY
                     KVIRDKSSSASFVLQALYKAYDENVDIINLSIGAYNALKNQKDLVEIREYNKIVKKLLD
                     MNTFIVSSIGNDQRRVFRYNSEYKTDDLYIMPASLDGVVGVASVKKNKDLVNYSNYGDC
                     ITICGYGGELGDSWNTNKIFDIRQMVLTTFPLAKEPSVIGKALDLPRGYDLTYGTSIAT
                     AQVTATIGLILSKLKKNKKKYEFEDVLKLLIRGAVSNSQNFKEVNEAGTRIVNAYNSLM
                     LIDNY"
     gene            15970..17349
                     /gene="radA"
                     /locus_tag="E4T61_RS00590"
                     /old_locus_tag="E4T61_00590"
     CDS             15970..17349
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="radA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017359160.1"
                     /locus_tag="E4T61_RS00590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00590"
                     /product="DNA repair protein RadA"
                     /protein_id="WP_015239037.1"
                     /transl_table=11
                     /translation="MAKSKTKFICHSCGYESAKWMGKCPGCGAWNTMVEETIKKAPANR
                     RAAFSHSVQTVQKPSPISSIETSEEPRVQTKLEEFNRVLGGGVVKGSLVLIGGDPGIGK
                     STLLLQVSAQLADTAGSVLYISGEESVKQTKLRADRLGINSQMLHVLSETDMEYISSAI
                     QEMKPAFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTNGIPIFIVGHVTKEG
                     SIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTEVLNPS
                     EIFLEERSAGASGSSIVASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNRVSLIMA
                     VLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAVAVSIASSFRDTPPNPADCFIGEVGL
                     TGEVRRVSRIEQRVKEAAKLGFKRMIIPEANADGWTIPKGIEVVGVANVAEALRTSLGG
                     S"
     gene            17353..18435
                     /gene="disA"
                     /locus_tag="E4T61_RS00595"
                     /old_locus_tag="E4T61_00595"
     CDS             17353..18435
                     /EC_number="2.7.7.85"
                     /codon_start=1
                     /gene="disA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_387969.1"
                     /locus_tag="E4T61_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00595"
                     /product="DNA integrity scanning diadenylate cyclase DisA"
                     /protein_id="WP_007615225.1"
                     /transl_table=11
                     /translation="MEKEKKGAKQELDLSAILQFVAPGTPLRAGIENVLRANTGGLIVV
                     GYNDKVKQVVDGGFHINTSFAPAHLYELAKMDGAIILSDSGQKILYANTQLMPEATISS
                     SETGMRHRTAERVAKQTGCLVIAISERRNVITLYQDSMKYTLKDIGFILTKANQAIQTL
                     EKYKTILDKTITALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTEGHLI
                     RLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSILFKLLGYPA
                     STNIDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGFLPSITEATVEELDDVEGIGEVRA
                     KKIKKGLKRLQEKHYIDRQL"
     gene            18549..19649
                     /locus_tag="E4T61_RS00600"
                     /old_locus_tag="E4T61_00600"
     CDS             18549..19649
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_387970.1"
                     /locus_tag="E4T61_RS00600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00600"
                     /product="PIN/TRAM domain-containing protein"
                     /protein_id="WP_003156403.1"
                     /transl_table=11
                     /translation="MLKRIVQAFFIIVGGVVGIFLIPELFVLSNIQDIPLITNAYTSAA
                     IGAIIFFLISIWTTEYVINWVKWIEDSLLRAPVPDLLFGSLGLVFGLIIAYLIVNVIPL
                     DNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGSADEEQEEQ
                     DKRLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRGRRGL
                     DILNRIQKELDITVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCELQKVA
                     VLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNYIGKHID
                     VLVTSVLQTAAGRMIFAKPKLLEKAL"
     gene            19662..20360
                     /gene="ispD"
                     /locus_tag="E4T61_RS00605"
                     /old_locus_tag="E4T61_00605"
     CDS             19662..20360
                     /EC_number="2.7.7.60"
                     /GO_function="GO:0050518 - 2-C-methyl-D-erythritol
                     4-phosphate cytidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009330349.1"
                     /locus_tag="E4T61_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00605"
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="WP_015239038.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.7e-15, bitscore:
                     54.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVVVIPAAGQGKRMKAGKNKLFISLKGAPVIIHTLRVFESHAP
                     CQKIILVINESEREDFRQLLAQFPIQTEIELVTGGAERQHSVYEGLKVIDKESVVLVHD
                     GARPFVTHQHIDKLVETAEEAGAAVLAVPVKDTIKRAEGSRVAETFDRSSLWAVQTPQA
                     FRLSLLKTAHMEAENKGFLGTDDASLVERLDGYQVSIVEGSYTNIKLTTPDDLIFAEAI
                     MKAESGNHNV"
     gene            20353..20829
                     /gene="ispF"
                     /locus_tag="E4T61_RS00610"
                     /old_locus_tag="E4T61_00610"
     CDS             20353..20829
                     /EC_number="4.6.1.12"
                     /GO_function="GO:0008685 - 2-C-methyl-D-erythritol
                     2,4-cyclodiphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003156407.1"
                     /locus_tag="E4T61_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00610"
                     /product="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
                     synthase"
                     /protein_id="WP_003156407.1"
                     /transl_table=11
                     /translation="MFRIGQGFDVHQLTEGRPLIIGGIEIPYEKGLLGHSDADVLLHTV
                     ADACLGAAGEGDIGKHFPDTDPEFKDADSFKLLQHVWNIVKEKGYVLGNIDCTIIAQKP
                     KMAPHIDAMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKA"
     gene            20921..22372
                     /gene="gltX"
                     /locus_tag="E4T61_RS00615"
                     /old_locus_tag="E4T61_00615"
     CDS             20921..22372
                     /EC_number="6.1.1.17"
                     /GO_component="GO:0009332 - glutamate-tRNA ligase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004818 - glutamate-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gltX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_387973.1"
                     /locus_tag="E4T61_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="E4T61_00615"
                     /product="glutamate--tRNA ligase"
                     /protein_id="WP_007410392.1"
                     /transl_table=11
                     /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARSQGGKFIIRIED
                     TDKKRNIEGGEQSQLNYLKWLGMDWDESVDIGGEYGPYRQSERNDIYKKYYEELLEKGL
                     AYKCFCTEEELEKEREEQIARGEMPRYSGKHRNLTQEEQEQFLAEGRQPSIRFRVPEGK
                     IIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDHISNT
                     PKQIMIFQAFGWDVPVFGHMTLIVNESRKKLSKRDESIIQFIEQYDELGYLPEALFNFI
                     GLLGWSPVGEEELFTREQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKALDLDQVVEL
                     TLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFKDEIEYNQEAK
                     AVLEEEQVPEVLSVFAAKLEELEEFTPELIKASIKAVQKETGHKGKKLFMPIRVAVTGQ
                     THGPELPQAIELIGRETAVRRLKSI"
     misc_binding    22375..22608
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
ORIGIN
        1 tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg tgaggtaacg
       61 gctcaccaag gcgacgatgc gtagccgacc tgagagggtg atcggccaca ctgggactga
      121 gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat ggacgaaagt
      181 ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct ctgttgttag
      241 ggaagaacaa gtgccgttca aatagggcgg caccttgacg gtacctaacc agaaagccac
      301 ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt ccggaattat
      361 tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc cggctcaacc
      421 ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg aattccacgt
      481 gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga ctctctggtc
      541 tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt
      601 ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag tgctgcagct
      661 aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca aaggaattga
      721 cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta
      781 ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg gggcagagtg
      841 acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac
      901 gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg tgactgccgg
      961 tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat gacctgggct
     1021 acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta agccaatccc
     1081 acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag ctggaatcgc
     1141 tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta cacaccgccc
     1201 gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta ggagccagcc
     1261 gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta tcggaaggtg
     1321 cggctggatc acctcctttc taaggatttt aacggaatat aagaccttgg gtcttataaa
     1381 cagaacgttc cctgtcttgt ttagttttga aggatcattc cttcaaaaca taggaacacc
     1441 tgctaaatgc gccacttcct gtggcaacgc atgtgttagc atgtcctatg cgttgttctt
     1501 tgaaaactag ataacagaag taattcacat tcaattagta atgcaagata tcacgtagtg
     1561 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg
     1621 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga
     1681 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaatacata
     1741 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc
     1801 aaatgcgatt ccctgagtag cggcgagcga aacgggacca gcccaaacca agaggcttgc
     1861 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt
     1921 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag
     1981 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc
     2041 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag
     2101 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc
     2161 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag
     2221 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcga attgagtacg
     2281 tggtcgtaga cccgaaacca ggtgatctac ccatgtccag ggtgaagttc aggtaacact
     2341 gaatggaggc ccgaacccac gcacgttgaa aagtgcgggg atgaggtgtg ggtaggggtg
     2401 aaatgccaat cgaacctgga gatagctggt tctctccgaa atagctttag ggctagcctc
     2461 aaggtaagag tctcggaggt agagcactga ttggactagg ggcccctacc gggttaccga
     2521 attcagtcaa actccgaatg ccgatgactt atccttggga gtcagactgc gagtgataag
     2581 atccgtagtc gaaagggaaa cagcccagac cgccagctaa ggtcccaaag tatacgttaa
     2641 gtggaaaagg atgtggagtt gcttagacaa ccaggatgtt ggcttagaag cagccaccat
     2701 ttaaagagtg cgtaatagct cactggtcga gtgactctgc gccgaaaatg taccggggct
     2761 aaacgtatca ccgaagctgc ggactgttct tcgaacagtg gtaggagagc gttctaaggg
     2821 ctgtgaagca agaccggaag gacttgtgga gcgcttagaa gtgagaatgc cggtatgagt
     2881 agcgaaagag gggtgagaat cccctccacc gaatgcctaa ggtttcctga ggaaggctcg
     2941 tccgctcagg gttagtcggg acctaagccg aggccgaaag gcgtaggcga tggacaacag
     3001 gttgatattc ctgtaccacc tcctcaccat ttgagcaatg gggggacgca ggaggatagg
     3061 gtaagcgcgg tattggatat ccgcgtccaa gcagttaggc tgggaaatag gcaaatccgt
     3121 ttcccgtgaa ggctgagctg tgatggcgag cgaattatag tagcgaagtt cctgattcca
     3181 cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac cgacacaggt
     3241 aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact cggcaaaatg
     3301 accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga gagccgcagt
     3361 gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg taaggcgaag
     3421 tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag cgtaagcgaa
     3481 ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta aggtagcgaa
     3541 attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg cactgtctca
     3601 acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc gacaggacgg
     3661 aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc ttgtacagga
     3721 taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt gggatactac
     3781 cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca gtgtcaggtg
     3841 ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa aggttccctc
     3901 agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac tgcgagacct
     3961 acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca tggaagggcc
     4021 atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc aagagtccac
     4081 atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc tgtagtcggt
     4141 cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca gaacgtcgtg
     4201 agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct gtccttagta
     4261 cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag ggcatcgctg
     4321 ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc ccccctcaag
     4381 atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg ttgataggtc
     4441 tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga ggacttaacc
     4501 aatttgaatg tatgcttact gttatctagt tttgagagaa cactctcaat ggtttggtgg
     4561 cgatagcgaa gaggtcacac ccgttcccat gccgaacacg gaagttaagc tcttcagcgc
     4621 cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcta tcattacggt
     4681 aaaggcagct catcatgagc tgcctttttt gtgtttttct gcatacgtta tataatatga
     4741 gaaacgtaac gatatgcctt tttgcaaaag caggttttat gcttgtacaa agtggaaata
     4801 atagagatag agcgatacag ttgaaaaatt ttgcgaaaca ccttatagta agattaaagt
     4861 caaatatagt caaagtcaat aaaggagggg gttgagtggg acataatatt tctgacatca
     4921 ttgaacagta cttgaaacaa gtattagatc aaaatggcaa agaaatttta gagatcaaac
     4981 gcagtgaaat cgctgataaa tttcaatgtg ttccttccca aataaattat gtcatcaaca
     5041 ccagatttac aagtgaaaga ggatatattg ttgaaagtaa acggggaggc ggcggttata
     5101 ttcgtattat caaaattaaa atgaataacg aagtcgtcct catcaataat attatttcgc
     5161 agattcatac ccacttgtcc caggcagcct ctgatgacat tattctcaga ctgttagagg
     5221 acggtgttat ttcggaaaga gaagctaaaa tgatggtgag tgtaatggat cgttcagttc
     5281 tatatattga tttgcccgaa cgggatgaac taagagccag aatgatgaaa gcaatgctca
     5341 catctttaaa actaaagtaa gcgggtgaaa agattgattt gtcaagaatg caatgagaga
     5401 ccggccactt ttcactttac gaaagttgtt aatggagaaa aacaagaagt tcatatttgt
     5461 gaacaatgtg caaaagaaaa tagcgattca tacagtataa gtggaaacca agggttctcg
     5521 atccataatt tattatcagg gctgctgaat atggagtcct catttcaaaa caccggttct
     5581 caaatgttcg gctactcaga gcaaggcaca gcttgtaaga aatgtggtat gacgtttcag
     5641 cagcttagaa aaacagggcg tttcggctgt gcggaatgtt acgatacgtt ctacagccaa
     5701 attacgccga tcttgcgaaa agttcacagc gggaatacgg tgcatgctgg gaaaattcca
     5761 aaacgaatag gcggaaacct gcatgtaaga cggcaaatgg aaatgttaaa aaaagaactt
     5821 gaatctttaa tacaccacga agagtttgaa agagcagcgg aggtcaggga tcagatccga
     5881 tcgttagagc agaagttaaa aagtaaagac agtgaggggg aacaagggta atgtcgctca
     5941 agcattttat tcaggacgca ctaagcaatt ggatgaagca aaagggacct gaaagtgaca
     6001 ttgtactcag cagccgtata cggttggccc gaaactttga aaatataaag tttcccgccc
     6061 ggtatacgaa tgaagaagcc tcatccatca ttcagcaatt cgaagatcat ttttcaggaa
     6121 aagaactgcc tgatatcggt caatttcatt taatcagaat gagtgaagct cagcctttgg
     6181 aaaaacgggt gctgatggag aaacatctga tcagtcctaa tttaacggaa tctccttttg
     6241 gcggctgtct gctttctgaa aatgaagaag tcagcattat gttaaatgaa gaagatcata
     6301 tcagaattca atgcctcttc cccggcttcc agcttctcaa tgccataaaa gcggcgaacc
     6361 aggttgatga ctggattgag gagaaagtgg attacgcctt tggagagaaa agagggtact
     6421 taacaagctg tcctacaaat gtagggacgg gactaagggc ttcagtcatg atgcatttgc
     6481 cgggccttgt attaactagg caaatgaatc gaattatacc ggcaattaat caattaggtt
     6541 tagttgttag aggaatttac ggtgaaggca gcgaagcatt aggaaatatc tttcaaattt
     6601 caaatcaaat cacactcgga aaatcagaac aggacattgt agatgattta aacagtgtgg
     6661 ctgcccagct gattgagcag gaacgttcag cccgagaagc gctttaccaa acctcgaaaa
     6721 ttgaattgga ggaccgggta ttcagatctt acggcgtttt atccaactgc cgtatgattg
     6781 aatcaaagga aacggcgaaa tgcctttctg acgttcggct ggggatagac ctggggatca
     6841 ttaaagggct atcaagcaat atacttaatg aactgatgat tttgacacag ccgggttttc
     6901 tccagcaata ttcgggcggt gcattacggc cgaacgaaag agacgcgaga agagcggctc
     6961 ttatcaggga aaggctgcat ttagaaatga gtgcaaatag acaggaggat gattcgatat
     7021 gatgtttgga aggtttacag agcgagctca aaaggtattg gcactggcac aggaagaagc
     7081 actgcgctta ggccatacaa atatcggaac tgaacatata ctattagggt tagtccgtga
     7141 aggtgaaggg atagcattta aagctttaga agcgcttggc cttaattcag ataaaatgca
     7201 gaaagaagtg gaaagtttga tcggtcgagg gcaggagagc accacctctg ttcctcatta
     7261 cacacctcga gccaaaaagg taatagagtt atcaatggat gaagctagaa agctaggaca
     7321 ttcttatgtg ggaacagaac acatacttct cggactgatt cgtgaaggag aaggcgtagc
     7381 ggcgagagtt ctgaataatc tcggtgtcag cttgaataag gcgagacagc aagtgctgca
     7441 gcttctggga agcaatgaga cgggatcttc tgcatccggt acgaacagca atgcaaacac
     7501 gccgacgctg gacagtctgg cgcgtgattt aactgcgatt gcgaaggaag acagtcttga
     7561 tccggttatc ggccgaagca aagaaattca gcgtgttatt gaggtattaa gccgcagaac
     7621 gaagaataac cccgttctta tcggagaacc gggtgtaggt aaaactgcga ttgctgaagg
     7681 cctcgcacag caggtcatca ataatgaagt gccggaaatt ttacgtgata aacgcgtaat
     7741 gacattagac atgggtacgg ttgtagccgg tacgaaatac cgcggagaat ttgaagaccg
     7801 cttgaaaaaa gtaatggatg aaatacgtca ggccggcaat attattttat tcattgacga
     7861 actgcataca ctgattggag cggggggagc agaaggtgcg attgacgcgt cgaatatctt
     7921 aaaaccttca ctggcccgcg gagagctcca atgcatcggt gcgacaacgc ttgatgaata
     7981 ccgtaaatat atcgaaaaag acgccgctct cgagcgccgt ttccagccga ttcaggtcga
     8041 tcagccctca gccgatgaaa gcattcaaat tttaaaagga ctccgtgacc gctatgaggc
     8101 gcatcaccgc gtatccatta ccgatgaagc gattgaagcg gcggtaaaat tgtccgaccg
     8161 ttatatttct gaccgcttcc ttccggataa agcgatcgat ttaattgatg aagccggttc
     8221 aaaagtgcgt ctccgttcgt tcacaacacc tccgaactta aaagagcttg agcagaaact
     8281 cgatgaagtt cgcaaggaaa aagacgctgc cgttcagagc caggagtttg aaaaagcggc
     8341 ttcccttcgt gatacggagc agcgcctgag agaacaggtg gaagacacga aaaaaacatg
     8401 gaaagaaaaa caaggccagg agaactccga agtttctgta gaggatatcg cgatggttgt
     8461 atccagctgg accggggtgc ctgtatctaa aattgcccaa acggaaacag ataagcttct
     8521 caatatggaa aacattctgc actcccgcgt catcggccag gatgaagctg ttgtagctgt
     8581 tgcaaaggct gtcagacgtg caagagccgg tctgaaggac ccgaaacgcc cgattggttc
     8641 attcatcttc ctaggcccta caggcgttgg gaagacagag ctggcaagag cgctggcgga
     8701 atccattttc ggtgatgagg aagcgatgat cagagtggat atgtccgaat acatggagaa
     8761 acactcaact tcacgtcttg tcggttctcc tccgggatat gtcggctatg atgaaggcgg
     8821 ccagctgaca gaaaaagtga gaagaaaacc ttactctgtc gtactgcttg atgaaattga
     8881 aaaagcgcac cctgatgtgt ttaacatact cctgcaagtg cttgaagacg gacgcttgac
     8941 tgattcaaaa ggacgcactg tggatttccg caacacgatc ctgattatga cgtcaaacgt
     9001 cggagcgagc gagctgaaac gcaacaaata tgtgggcttc aatgtgcagg atgaatcaca
     9061 aaaccataaa gacatgaaag acaaagtcat gggagagctg aagcgtgcct tcagacctga
     9121 gtttatcaac cggattgacg aaattatcgt cttccactcc cttgagaaaa aacaccttac
     9181 agacatcgtg tcgctaatgt ctgatcagtt aacaaaacgt ctgaaagaac aagatctctc
     9241 tatcgagctg acggatgctg caaaagcgaa agtggcagaa gagggcgtcg atttggaata
     9301 cggcgcacgt ccgttaagaa gagcgattca aaagcatgtg gaggaccggt tatcagaaga
     9361 actcctcaga ggcaatattg ataaaggcca gcacattgtt cttgatgttg aggacggcga
     9421 atttgtcgta aaaacaactg ctaaaacgga tgcttaaaat gttattaaat taaatatgag
     9481 aagacgtgca gcgaatcttg cacgtctttt ttaaaaggta aagttattat taaatcttag
     9541 atcgttagca caaggttaaa gtgtgtgaac atacgaaacc atcagtcggt aaataggaag
     9601 cgaggcatag aagcactaat ccaaaaatag aattttgtga taattgttgc gatccatttg
     9661 gaaatatatt ataatttgct tgtatcaaat tacagggagg taaaaatatg tcagaaaagc
     9721 agattgaaag aaccattaga gcatggaaag atcctgaatt tagaaaaact ttatcggatg
     9781 tagcagatca tccatctggg tctatagaag ctcgccaatt atcaatgctt ggtagtgagg
     9841 aaaatgttaa ccctatgaca accccagtta gtcctgcacc aactgtagtt attcgagtaa
     9901 gtttgaaagt ctgtcctaca tttaaaataa aatgtaaagt ttaaaactta cttaaaaaga
     9961 gggctcgtgg agtcctcttt tttgagagga gaatgttcat atgtctaatt tatttgatga
    10021 attcaaaaat ggttcatata taagtgaaag aattccggat agaggtacca aaatcatcca
    10081 tgaccaatat gaaaaatggg tattaacttc aggtttaaaa aaagaagtgt ttgaagagaa
    10141 aatagagaaa tattataagg gtttcaacat ttttagtaag gtgatttctt ccggatgtga
    10201 ttttgaaatt agtgatagat tgtggataga taggttaaat gaaattttta aagaaactta
    10261 taaatacaat ggtaaccatt cctataaaca atcagttttt tactacttta attatccatt
    10321 tttagattgg gcattacgaa aaatagactt tgaattcagt catatcttcg actatagtta
    10381 cattaacgcg gtaaagctac gtgattcttt aataaacgca atacaagaaa acctggattc
    10441 attagtttca agaactctta tacttgatct aaatatcgaa aggttaaaag gaaacttagt
    10501 tggaaaaacc tcagatgaaa ggtatcattc ctattcaaaa aaatttttag agagtccaaa
    10561 agaaatctta aaagtattga aagagtattc agttttagcg agattgattg taagctctgt
    10621 tgaaaaaaat ataaataatt ttaaagagac cttatcacgt tacattagtg atagacgtga
    10681 tcttatagag aaaaagttca tttcagatag cgttcttgtt tctttagaga agggattggg
    10741 tgatgatcat aataatggta gaagtataat gtgtttaaaa tttgataacg gtcataaact
    10801 catctataaa ccaagatcat tacatatgga taagaaattt gaagaactta ttacatggat
    10861 taatcaaaaa aaatttcaac ctgaattaaa atatgctaag tcaattgata aaaagagcta
    10921 cggatggcag aagtttatta attatagagc atgtaataaa gaaaaagaca ttgaattatt
    10981 ttatgaacgg caaggtgcat atactgcctt attatatata cttaatgcta cggatttcca
    11041 tttggaaaac atgattgccc attctgctta tcctatttta gttgaccttg aatcgctctt
    11101 ccaaaataag attgaacata aaagttataa tatagtagat gaattagctt gggataaaat
    11161 taataattca gtgattttaa cagggatgtt acctgttagt aattatacgg gtgttgaatt
    11221 tgatttaagt ggaattggag gaaatgggaa ccaagaactt ccatttgagt cgtttgattt
    11281 ccaaaatgtt ggaacagata atatgaagct tgttaaaaca aaacaagagt ataaaggttc
    11341 tcaaaatcaa ccacttactt cgaatgacgc aattcagcct agtaaataca tagaatcaat
    11401 tattaaaggc tttacatcct tatataattt gtttaaagaa aacaaaagag aactcttaga
    11461 tgaagatggg cctattgaag cttttaaaga cgtatatttt agatttattt atcggaatac
    11521 agcgacatat gctgagttct tagaatggag tttacatcct gattatttaa tgaacggttt
    11581 agatagaaat ctactttttg aaaatatatg gaataaaaaa catcttcaaa atttagatat
    11641 tatattcagt gaatataatg atttattaaa ccatgatata ccttattttt acgcaggtat
    11701 taattcaaaa gatttaatta catcaagagg agaaagaatt tcaagttttt ttgagaaaga
    11761 gtctttaact atagtaaaag aaagaataaa acaacttagt acaatggatt ataaacaaca
    11821 aattgaattt ataagacagt gtttttctaa tttaagtgaa acccaatcca atttaaaata
    11881 cagcgagaat tttgaaaaaa gtgtagataa gactcttgca gaattaatag gtgatttcct
    11941 tataagcaag tccattatag acgttaataa taattttgta acttttattt caaaaaaaca
    12001 aatagatagt gaaaagttca tattatctcc aatagatgaa agtttgtatg agggcgtttt
    12061 aggcgtcggt ttattttttc tttatttgaa tagacaatat aataaagatg aatataaaaa
    12121 tatggcactg agatgcataa acagtgcgaa aattaaaatc aacgagaacg aaaatatttc
    12181 agcgttttat ggattatgct catacttata tgttcttaat cattatattt acttttttcc
    12241 tgaaaaaaag agagaatttg ctgaagatat aaagatggtt cttaataaac ttgattcttt
    12301 taaacataat tataataatg aaattgattt tataggtgga tatgcagggg ctattattgt
    12361 tttattgaat atctactgta cattacgtat agaagatgca ctgagtttgg caaaatcttt
    12421 tggtagcttt gttcttgagt atatagacag tagtgtcgaa aaagatgagt ttaaaatgct
    12481 cacaggaatt tctcatggtg cctcgggtat tgctttagct ctaaaaaaac ttgaagatgt
    12541 taccggagat aagatctatg aagattacat caatatgtta atagaatacg aggattacca
    12601 ctattcaaga gaaaagaaga attggagaga tttaagaaat ataaataatg aatatcaaaa
    12661 tttttggtgc catggagcac ctggcatctt attagctaga agtaatatga atagaaattt
    12721 tgacggtgca gaacaaaaaa taataatcga taagttatta tctagaaaat ataatgatat
    12781 aactctatgt catgggaagt taggagttca attgataatt ttggaattag caaaaaaaca
    12841 aaataatcaa acgttaattc atttagtatc tgatagtata gaggaaatag agaggtctct
    12901 aaattcagat agaattaaac aaaagtttga actagacttt ggattaatga caggagctgc
    12961 aggagtagga tatgccctgc tttatggaaa tgacttttta ggtatgccga atatcctgac
    13021 tttagagcaa cctatattgt aggccttcta tatttagaag gcttacaaaa ttcaaatttg
    13081 tggtgatatt gtgaaacaag tttacaaatt attaaaggtt atagaattac cgaaatatgt
    13141 attgatgata tgtttactat tgagtttact agagacagca tttagcttat caataccact
    13201 tcttacaagg gagttggtgg atagtttttc aaaaggtctt gattttacta agattattgt
    13261 tttaactcta gtattgctat tccaaacctt tctttcaggt attttattgt atctcttgaa
    13321 ccgtattgga caaaaagtag tcaaatctat acgggtgaag ggtatcgaaa aaatattcac
    13381 ttttaatatg gggttttttg agaaaaacaa atctggggat attataagca aaataactaa
    13441 tgatacctta attattaaag atttctttgg aagcgattta atatctttta tatccggtat
    13501 tatagctgtt attggttcgg taataatact gatagttttg gattggagat taactttagt
    13561 tttaattata tcaatacctt taatatcatt atttttatta ccaatgggcg gaaaagttct
    13621 ttcgatatcc caaagacaac aacattatgt gggatcttta acatcttttt tgaaccgagt
    13681 tttggataat attaaattaa taaagatatc caatacagaa agccttgaag aaaaaaaagg
    13741 cattgaaaat gctactcaca tctatagaga gtcaataaaa gaagcgaaaa ttttttctat
    13801 attaacgcca ctgattagtt tagttttaat gctgattatt gttagtataa ttatgtatgg
    13861 gggttataga gtttcatcac atactttaac aagcggggat ttgatggcgt ttataatgta
    13921 tttgattcaa ataataattc ctgtaagttc aattggggag ttttttgtta cttataaaaa
    13981 gtcattagga gcaattaaca gagttaatga tctaatattc aataaagaag tagaaaaaaa
    14041 agaagggctg aaatacagcg aacctaatac taacatactt tttaaaaatg taagttttag
    14101 ctataacgag gaaaaggaaa ctttaaaaga catatccttt agtttgaaac caggtactgt
    14161 tacagcttta gttggcccca gtggggcagg aaaaaccact atattttccc tgttagagcg
    14221 tttatacgag cctaaaagcg gagggatttt tttaaataat aaattaattt ctgaatatga
    14281 attacaagag tggagaaaac aaattggtta tgtaactcag gagactccaa taatcgatgg
    14341 aaccatacta gacaatatat tgtacggaac aaagggtgat tttacaaagg aacaaataga
    14401 tagtgttctt gaaagaacgt atttaaaaaa agatgttgga ggtttctcta agggaatata
    14461 cactgaagtt ggagaaaagg ggatgaaatt gtctgctgga caaagacaaa gaattgcaat
    14521 agctcgggta attcttagag atcccaaact attattgttg gatgaagcaa catcgaatct
    14581 agatagttat tcagaggaaa taatcaaaaa aactctagac tacttaatgg gggagaaaac
    14641 tagtttggtt attgcgcata gattatctac aatattatct gcggacaata tcattatact
    14701 agaaaatggt cgtgtttctg ggtcaggtac tcataaagat ctatatgaaa tgcatccttt
    14761 atataaaagg ttagtagata tacagtttga cctatcggag gttaagtaga tttaatgaaa
    14821 actttagagt taatacaaaa tgctgattta tatcaaaagt ggggatgggc tgtagattta
    14881 gtaacagaca atgggaaaac cttttattct gaaaaaggga gtcaagatgt taaaatagca
    14941 attatagata gcggtattga tacggatcat ccagacttaa aagagaacat tcttttggaa
    15001 aaagcaatgt cttttataga cgattcaatt gatgataaaa ttggtcatgg tactcaaatt
    15061 gctggaatca ttgcagctaa tggaagatta ttggggattg gtccggagtt aaaaattatc
    15121 ccatataaag ttataaggga taagtcttca agtgcaagtt ttgtattaca agctctctat
    15181 aaggcatatg atgaaaatgt agatataatt aacttaagta taggggcata taatgctcta
    15241 aaaaaccaga aagatttagt tgaaataaga gaatataata aaattgttaa gaaactgttg
    15301 gatatgaata catttatagt atcatccatt ggaaacgatc aacggagagt ttttaggtat
    15361 aattcagaat ataagactga cgatttatat ataatgcctg cttctctaga cggtgttgta
    15421 ggtgtagctt ctgtaaagaa aaataaggat ttggttaatt attctaatta tggagattgc
    15481 ataactatat gtggctatgg gggagagtta ggagactctt ggaatactaa taaaattttt
    15541 gatataaggc aaatggtttt aaccacattt ccgttagcta aagaaccttc tgttatcgga
    15601 aaagcattgg atctaccaag aggatatgac ctaacttatg gaacaagcat cgcaactgct
    15661 caagttacag ccacaatagg attaatttta tcaaaattaa aaaagaataa aaagaaatat
    15721 gaatttgaag atgtattaaa gctccttata aggggagctg tttcaaactc tcaaaatttt
    15781 aaagaggtaa atgaagcggg aactcgaatt gtaaatgcat acaatagttt aatgcttatc
    15841 gataactatt gaataaaatg aaactacaga tcattattct gtcgtaaaaa caatacacag
    15901 cacgaacttt ttaaagacat acatatatta cggtatgtct taattttata gtaagaggaa
    15961 gattcatata tggctaaatc aaaaacaaaa ttcatctgcc actcatgcgg atatgaatcc
    16021 gcaaaatgga tgggaaagtg cccgggctgc ggggcttgga atacaatggt ggaagaaacc
    16081 ataaaaaaag cgccggcgaa tcggcgggcg gctttctccc actccgttca aaccgtccag
    16141 aaaccatcac ccatttcatc aattgaaaca tcggaagaac cccgcgtcca aacaaagctc
    16201 gaagaattca acagagtgct tggcggcggc gttgtgaaag gctcgttagt attaatcggc
    16261 ggcgatcccg ggatcggaaa atcaacgctc cttctccaag tatccgcaca attagcagat
    16321 acggctggca gcgtgcttta catttcaggg gaagaatccg tgaagcaaac gaagctgcgc
    16381 gccgacagac ttggaatcaa cagccaaatg ttacatgttt tatctgaaac cgatatggag
    16441 tatatttcgt ctgctataca agagatgaaa cccgcatttg ttgtcgtaga ctccattcag
    16501 accgtttacc aaagtgatat cacctcagct cccggcagtg tatcacaagt aagagagtgt
    16561 acggccgaat tgatgaaaat cgcgaaaaca aacggcatac ctatttttat cgtcgggcac
    16621 gtcacaaaag aaggatcgat cgcagggccg agattgcttg agcacatggt cgataccgtt
    16681 ctatactttg aaggagagcg gcaccataca ttccgtattt tgcgggccgt aaaaaaccgt
    16741 ttcggctcca caaatgaaat gggcatcttt gaaatgcggg aagaggggct tacggaagtg
    16801 ctgaaccctt ctgaaatttt cttggaagag cgttctgccg gggcatcggg ttcgagtatc
    16861 gttgcgtcaa tggaaggaac gagaccgatc ctggttgaaa ttcaggcgct catatcaccg
    16921 accagttttg gaaacccgcg ccgcatggct acaggcattg accacaacag ggtatcgtta
    16981 attatggctg tgcttgagaa gcgggtgggt cttttgcttc aaaatcaaga tgcgtattta
    17041 aaggtcgccg gcggggtcaa actggatgaa ccggcgattg atttggcagt agccgtcagc
    17101 attgcttcaa gcttcagaga tacaccgccg aatcccgcag attgctttat cggtgaagtg
    17161 ggtctgacag gagaagtccg cagggtgtca agaatcgaac agcgcgtaaa agaagcggcg
    17221 aaactcggct tcaagcgcat gatcatacct gaggcgaatg cagacgggtg gacaatacca
    17281 aaagggattg aggttgtcgg agtagcaaat gttgcagaag cgcttcgtac ttcattagga
    17341 ggatcataat agatggaaaa agagaaaaaa ggggcgaaac aagagcttga cctgtctgca
    17401 attctgcagt tcgttgcacc gggcaccccg ctcagagccg ggatagagaa tgtacttcgg
    17461 gcaaatacag gcggcctgat tgttgtcgga tacaatgata aggtaaagca agtcgtggat
    17521 ggcggttttc atattaatac atcatttgcg cccgctcact tatacgagct ggccaaaatg
    17581 gacggtgcca ttattttaag tgattccggc cagaaaattc tttatgcgaa tacgcagctt
    17641 atgccggagg cgaccatttc ttcttcagaa acgggaatga ggcaccgtac ggcggaacgg
    17701 gtggcgaagc agaccggctg tctcgtcatc gccatttctg agcgcagaaa tgtcattacg
    17761 ttatatcagg acagcatgaa gtacacacta aaggacatag gatttatttt aacaaaggca
    17821 aatcaggcca ttcaaacgct tgagaagtat aaaaccattt tagacaaaac gattacggct
    17881 ttaaacgcat tagagtttga ggagcttgtg acattcagtg acgtgctgtc cgtcatgcat
    17941 cgatatgaaa tggtgctccg aataaaaaat gaaatcaata tgtatattaa agaactcgga
    18001 acggaaggcc acttaatccg tctgcaggtg attgaactga ttacggacat ggaggaagag
    18061 gcggcacttt tcatcaaaga ctatgtcaaa gaaaaaatca aagatccgtt cgtgctgtta
    18121 aaagagcttc aggatatgtc cagctatgat ctgcttgatg attccattct gtttaagctg
    18181 cttggatatc cggcttctac caatattgat gattatgtgc tcccgagagg atacaggctg
    18241 ctgaacaaaa ttccgcgtct gccgatgccg attgttgaaa atgtggttga ggcgttcgga
    18301 tttttgccaa gcataacgga agccactgta gaagagcttg atgatgttga gggtatcggc
    18361 gaagtgcgcg ccaaaaaaat caaaaaaggc ttaaaacgcc ttcaggaaaa acactatata
    18421 gatagacagc tttaagaatc gcttaaacct gtcggaatcc gggtatatta ttgttagttt
    18481 ttgtttattc tgaatttgta ggctctgaca gtctgctgaa aaaatgctac ttaaaaggag
    18541 gtggaggtat gttaaaacga atagttcagg cgttcttcat tattgtgggc ggcgttgtcg
    18601 gtatcttctt aatacctgaa ttgtttgtgc tgtcaaatat acaggacata cctttaataa
    18661 caaacgcata tacgtctgct gcaattggtg ctattatctt ttttctcatc agtatatgga
    18721 cgacagaata tgtgattaat tgggtaaaat ggattgaaga ttctttgctg agagctccgg
    18781 tgccggatct gttattcggg agtctcggat tggtttttgg acttatcatc gcatatctca
    18841 ttgtaaacgt gattccgctg gacaatattc cgtaccgtat attcagcacc atcattccgg
    18901 tctttctggc tttctttctc ggttacctgg gcttccaagt cggatttaag aaaaaggatg
    18961 aactgatcag tcttttctcc atttctgcaa gaatgcagaa gaaaaaggga agtgctgatg
    19021 aggagcagga ggaacaggat aaaaggctga aaatcttgga tacaagtgtt attattgatg
    19081 ggagaattgc agatatttgt cagacgggct ttttagaagg cgtcattgtc attcctcaat
    19141 ttgtgctgga ggaattacag catatcgctg attcttcaga tgttttaaaa cgtaacagag
    19201 ggcgccgcgg actggatatc ttgaatcgca ttcaaaagga actggatatt acggttgaaa
    19261 tttatgaagg cgactttgag gacattcagg aggttgacag caagcttgtc aaacttgcga
    19321 agctgacatc cggcgtcgtt gtgacgaatg attttaattt aaataaagta tgtgagcttc
    19381 agaaggttgc ggtactgaat attaatgacc ttgcaaacgc ggtgaagccg gttgtgcttc
    19441 cgggcgaaga gatgaatgtg caggtgatta aggacgggaa agagcataat caaggtgtgg
    19501 cttacttgga tgacgggacg atgattgttg tggaagaagg ccgcaattat atagggaaac
    19561 atattgatgt gctcgtaacc agcgtactgc agacagcggc gggacgaatg atttttgcca
    19621 agcccaagct gcttgagaaa gctctttaag agggagttca tatggagtat gttgtcgtta
    19681 ttccggctgc cggacaagga aaacggatga aggccgggaa aaataagctg ttcatcagct
    19741 taaaaggtgc gcctgttatt atacacacac tgcgggtttt tgaaagccac gcaccctgtc
    19801 agaaaataat cttggtgata aacgagagtg aacgggaaga ttttcgccag ctgctggccc
    19861 aatttccgat tcagacggaa attgagcttg ttaccggagg tgcggagcgt cagcacagtg
    19921 tatacgaagg actgaaagtg attgataagg aatcggtcgt ccttgttcat gacggagcgc
    19981 gcccgtttgt cacacatcag catatcgata agctcgtgga aacagcagag gaggcgggag
    20041 cggctgtcct ggctgttcct gtgaaagaca cgataaaacg ggcggaaggc tcccgggttg
    20101 cggagacctt tgatcgttca agcttgtggg ccgttcaaac gccgcaagct tttcgtcttt
    20161 ctttattgaa gacggcgcat atggaagcgg aaaacaaagg cttcttaggg acggatgacg
    20221 ccagcctcgt cgagcgtctt gatggatatc aggtgagtat cgttgaaggc agctatacca
    20281 atattaagct gacaacgccg gatgacctga tatttgcgga agcaatcatg aaagcggaaa
    20341 gtgggaatca taatgtttag aatcggacaa ggatttgatg tgcatcaatt aacggaaggc
    20401 cgtcctctca tcatcggcgg aattgaaatt ccttatgaaa aggggctgct cggacattca
    20461 gatgctgatg tattgctgca tacagtcgca gacgcgtgtc tcggagcggc aggtgaagga
    20521 gatatcggca agcatttccc ggatactgat ccggaattca aggatgcgga ttcttttaag
    20581 ctgcttcagc atgtctggaa cattgtaaaa gaaaaagggt acgtactcgg aaatatagac
    20641 tgcacgatta ttgcgcaaaa gccgaaaatg gcgccgcata ttgatgctat gagaaaacgg
    20701 atagcggaag gccttgaggc ggacgtctct caagtaaacg taaaagcgac gacgacagaa
    20761 aagctcgggt ttaccggaag agccgaagga attgccgctc aggcaaccgt tctgatccaa
    20821 aaagcctgat cattgttttg atgcccggtc tatttggtgg tagaatagat acatatattc
    20881 ggctagaggc tacagacgag atgaaaggaa gtatttgaac atgggaaatg aagtacgcgt
    20941 tcgttatgca ccgagtccga ccggacattt gcatatcggt aacgccagaa cggcgctttt
    21001 taactattta tttgcccgca gccaaggcgg aaagtttatt atccggattg aggatacgga
    21061 caaaaagcga aatattgaag gcggagagca aagccagctc aactatttga aatggctcgg
    21121 catggactgg gatgaaagtg tggatatcgg gggagaatac ggcccgtacc gccagtctga
    21181 gcgtaacgac atttacaaaa agtactatga agagcttctt gaaaaagggc ttgcttataa
    21241 atgtttctgt acggaagaag aacttgagaa agaacgtgaa gagcaaatcg cccgcgggga
    21301 aatgccgcgc tattccggca aacacagaaa cctgactcag gaagagcagg agcagttttt
    21361 agccgaaggc agacagccga gcatccgttt ccgcgtgccg gaagggaaaa tcatcgcatt
    21421 taacgatatc gtaaaaggcg agatttcttt tgaatcagac ggcatcggcg actttgtcat
    21481 cgtcaaaaaa gacggaacac cgacgtataa ctttgccgtc gcgattgacg attacttaat
    21541 gaaaatgacg cacgtgctcc gcggtgagga tcacatttca aatacaccga aacagatcat
    21601 gattttccag gcattcggct gggatgttcc tgtcttcgga catatgacgc ttatcgtaaa
    21661 cgaaagccgc aaaaaattaa gtaaacgtga tgaatcaatt atccagttta ttgagcagta
    21721 tgatgagctg ggttacctgc ctgaagcgct gtttaacttt atcggacttc tcggctggtc
    21781 tcccgtcggt gaagaagagc ttttcacaag agaacaattc attgaaattt ttgatgtaaa
    21841 tcgtttgtct aagtcaccgg ctctgtttga tatgcataaa ctgaaatggg tcaacaacca
    21901 atacgtcaaa gcgctggatc ttgatcaagt ggttgagctg accctgccgc acctgcaaaa
    21961 agcaggaaaa gtcggcactg agctttctgc cgaggagcag gaatgggttc gtaaattaat
    22021 ctctctttac catgagcaat tgagctacgg cgctgaaatt gtcgagctga ctgatttgtt
    22081 ctttaaagat gagatcgagt ataatcaaga ggcaaaagcc gttctggaag aggaacaggt
    22141 gcctgaagtg ctcagcgtat ttgctgcgaa gcttgaagag cttgaagaat ttacgcctga
    22201 gctgatcaaa gcctcaatca aagctgttca gaaagaaaca ggccataaag gcaaaaagct
    22261 gttcatgccg attcgtgtag cggttaccgg tcagacacac ggtcctgagc ttccgcaggc
    22321 cattgagctg atcggcagag aaacagccgt cagacgcctg aaaagcattt aaatatacga
    22381 ttgttgacag ggaagagtat aaaacaatga ccattacaga aagaatcttc atcggctgag
    22441 agagattcat gcgtcatgtt ttagaagtgc gcccttaaga cctttgaaga acatttctgc
    22501 ggaaatcagt atttaaaggc ggccgccgcc gttaccggct tttaagttgg gaaaacagtg
    22561 acttgttttt caaacagagt ggaaccgcgc ggtaaaagcg tctctgtcat gtttacatgc
    22621 agaggcgctt tttttatagg cggaaaaaca gactggagcg gggagagaat ggggggaagc
    22681 atgtgttttt taaaatgcta aaagaagaca tagatacagt gttcgatcaa gatccggcag
    22741 caagaagcta tttcgaagtt gttttaactt attctggttt acatgctata tgggcgcatc
    22801 ggattgcaca tgctttatat aaacggagat ttttcttcct ggcgcgcctg atatcacaga
    22861 ttgcccgttt ctttaccgga attgaaatcc atcccggcgc gaccatcggg agaaggtttt
    22921 tcattgacca cggtatgggg gtcgtcatag gggaaacatg tgaaatcggc aataacgtga
    22981 cggtattcca aggtgtcact ctcgggggaa cgggaaaaga aaaggggaag cggcatccga
    23041 cc
//
