LOCUS       NZ_CP039292            21182 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Actinomyces procaprae strain dk561 chromosome, complete genome.
ACCESSION   NZ_CP039292
VERSION     NZ_CP039292.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces procaprae
  ORGANISM  Actinomyces procaprae
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3600355)
  AUTHORS   Dong,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2019) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, Changping District Changbai Road, No. 155, Beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 278.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004798665.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:44:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,013
            CDSs (total)                      :: 2,952
            Genes (coding)                    :: 2,897
            CDSs (with protein)               :: 2,897
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 24 of 55
            Pseudo Genes (incomplete)         :: 35 of 55
            Pseudo Genes (internal stop)      :: 2 of 55
            Pseudo Genes (multiple problems)  :: 5 of 55
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:51:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1838243
            Orig. end                         :: 1859425
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP039292.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21182
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21182
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21182
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11182](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11182
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(615..857)
                     /locus_tag="E4J16_RS07375"
     CDS             complement(615..857)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E4J16_RS07375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_136193257.1"
                     /transl_table=11
                     /translation="MRALLGRGAAAGRTGGGADGVGPGGPEGAAGDATAALAAHIRSRT
                     GLVLTPGTAYGAAGAGFLRMNLGAQRARVEDGPTV"
     gene            complement(943..1416)
                     /locus_tag="E4J16_RS07380"
     CDS             complement(943..1416)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023955.4"
                     /locus_tag="E4J16_RS07380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3737 family protein"
                     /protein_id="WP_136193256.1"
                     /transl_table=11
                     /translation="MTLTASPSTAAEAPDGCPGDVGSVVDHRRLTGERALYAAQDLTIS
                     HSTFADGESPLKESRGLRISDTVFEWKYPLWYCRDVSVSGGALLETARSGIWYTDDIRL
                     DGTLVAAPKTFRRGRGISLRRVELPHAEETLWSCREITLEDLVGAGARLHRRQ"
     gene            complement(1540..2595)
                     /locus_tag="E4J16_RS07385"
     CDS             complement(1540..2595)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009233856.1"
                     /locus_tag="E4J16_RS07385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_136193255.1"
                     /transl_table=11
                     /translation="MTPVYGSTRRTGPGGPWAMFRPGPRSALPRSLTWAPLGPRDNAEL
                     AELVARSEAVDNPPYRTSAQETAEYFVDPTYSGVAGRDETGVMRAFGLVRLRPAAEIYA
                     SMTGTVDPAWRQRGIGVALLHWQTERARHLIGSERAGEVAGSAAATAPAHIVTTVLEDD
                     ERMKDHLAELRFEPRRWYREVRRSLTDAIPEIDLDGFLTIEPWSEELDDAVRRAHNQAF
                     ADSGGGAMSPEEWRAGRAYFAPQWSFVAMDRSGDRARVAGYVLSSRYEQDWAALGWREG
                     YTDVIGVLADYRSRDVGPALLGAVMRAYAADGMEYAAAGFESDDPSGAVDLFRDLGYTA
                     TRGTILYGLDV"
     gene            complement(2739..4958)
                     /locus_tag="E4J16_RS07390"
     CDS             complement(2739..4958)
                     /EC_number="5.6.2.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006549607.1"
                     /locus_tag="E4J16_RS07390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="WP_136193254.1"
                     /transl_table=11
                     /translation="MPDSSQSYSARHLSVLEGLEAVRKRPGMYIGSTDQRGLMHCVWEI
                     IDNGVDEALEGYGDRIAVVVHADGSIEVRDTGRGVPVDIEPSSGLTGVELVYTKLHAGG
                     KFGGGSYGSAGGLHGVGASVVNALSARMDVEVDRGGKTYAMSFRRGVPGVFSDPSTGPT
                     PAAPFEEYTEATQLRVIGKVRRGVTGTRVRYWADPEIFPAPDQYDVTALRARLRQTSFL
                     VPGLTLTLTDERDPETSAATASGPTAADPALSAKAAHTAAPAGDLFTSGAPDEESTETF
                     HAEGGTADFVDFLATDGSVTDTFRLTGEGTYTETVQQLDKRTGHLRPTEVERTCTVDVA
                     LRWGIGYDTTERSFVNIIATPMGGTHLAGFEQAVTKVLRKQIDANSRALKVTSRDGRIE
                     KDDILAGMTAVITVRVPEPQFEGQTKEVLGTAPVRQIVAKVVEKELTALLTSSKRDLKT
                     QSRALQEKIVGEMRARVSARMHKEITRRKTALETSTLPAKLADCRSDDVASSELFIVEG
                     DSALGTAKNARNSEFQALLPIRGKILNVQKASQADMLRNAECSAIIQVVGAGSGRTFDL
                     EAARYGKVILMTDADVDGAHIRTLLLTLFFRYMRPMIEAGRVFAAVPPLHRIEVSAQGR
                     RKREVIYTYSDEELVTTLRKLEKQGRSFKEPQRYKGLGEMDAHQLAETTMEPEHRTLRR
                     ITLRDEAELAEAENVFELLMGSNVEPRRDFIIEGAADVDRERIDA"
     gene            5173..5451
                     /locus_tag="E4J16_RS07395"
     CDS             5173..5451
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003780431.1"
                     /locus_tag="E4J16_RS07395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_136193253.1"
                     /transl_table=11
                     /translation="MSTTTPMSPTVAARAAAPEQAVGPAQATEARPLTTADRCDVCGAQ
                     AYLRVVLASGELLFCAHHGHAHQEALERQALFIQDESDRLTRPAEVD"
     gene            complement(5402..6352)
                     /gene="thiD"
                     /locus_tag="E4J16_RS07400"
     CDS             complement(5402..6352)
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018022528.1"
                     /locus_tag="E4J16_RS07400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="WP_136193252.1"
                     /transl_table=11
                     /translation="MSDVTPACVVDAPSCGAPVPKVLTIAGSDPSGGAGIQADLKTMGA
                     LGAYGMSVVTALTAQSTRGVTGVHTVPAGFVRLQLDTLLVDIRPDATKIGMLATSETAE
                     AVGEYLARMANTVLDPVMVATSGDRLLDAAAMDAVRRLCARADLITPNLPEAAALLGRA
                     PAADTDEMRRQAELLLAAGARRVLLKGGHLLGEASDVYADAEGTVLLPGPRVNTDNTHG
                     TGCTLSAAIAALRPQRDSWITAVREAKTYLSGALAHADGLTVGHGHGPVHHYYALWPSR
                     PEGVGGKRQDPAGAPPVQSVSRPRRGGSGGRTHPE"
     gene            complement(6349..7005)
                     /gene="thiE"
                     /locus_tag="E4J16_RS07405"
     CDS             complement(6349..7005)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749743.1"
                     /locus_tag="E4J16_RS07405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_136193251.1"
                     /transl_table=11
                     /translation="MRAAPDLRVYLVTDAAQCRARGRTVTDTVRAAVAGGATCVQVRAK
                     HADGADFLTQVLDVAHAVGRQVPVIVNDRVDVFLAARRLGAPVAGVHVGQRDLPAAVVR
                     ELIGDDAYLGLSAATPAELATAQAEGACDHVGIGAVRATTTKPDAPAGLGAPGIARLAA
                     GTDLPCVAIGGVTAADLPALRAGGLAGAAVVSAICLADDPRAAARALRRAWESGQ"
     gene            complement(7002..7874)
                     /gene="thiM"
                     /locus_tag="E4J16_RS07410"
     CDS             complement(7002..7874)
                     /EC_number="2.7.1.50"
                     /GO_function="GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005962561.1"
                     /locus_tag="E4J16_RS07410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="WP_136313654.1"
                     /transl_table=11
                     /translation="MTQRAHANTHPNDRPAEPSILRVPAPPPGAVEVLESLRSTGPLVA
                     CITNAVVTNFTANVLLAVGAAPAMVDVTGEAGPFAAGACALLINLGTPQPEQRSAAVEA
                     ATAARAAGVPWVLDPVAVGTLVHRTALAHRLLDEAPTVIRGNASEIIALAGSGAGGRGV
                     DSADDVEAALDAARSLSERTGAVIAVSGPMDAIVDGARVTRVGGGSALLTRVTGGGCAL
                     GALVAGFVAAGRASGADAGAATVACHAAYSAAAEIAAETAAGPGSFRIALLDALYALDA
                     DDLARIPVI"
     regulatory      complement(7864..7952)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(8038..9732)
                     /locus_tag="E4J16_RS15705"
     CDS             complement(8038..9732)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009747452.1"
                     /locus_tag="E4J16_RS15705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_136193249.1"
                     /transl_table=11
                     /translation="MATSTVAPAPTTRRERVELADDVDEVLEDRQDVELDAEDDLDEED
                     DLDAEDDYDGEDDYDDADSAQADDEDDAEDDSDEDAGESEEAAAPAPELRDYYLDVSLE
                     ENGDGTKRHPFNTPAALKSVRLAPGATLFVRSRTVVEGLEISGDGTLDEPITLAPYGHG
                     PVPRFVVPGEEEPVVAREFLTKNGFIFRGWIIKGIKMNPSIAALTGELDRLRREEAEKT
                     AGKKSKKAKTGEKSKDGSFTVSDSDEGDEPAQKVVTAGATADPVKDYLKQIGKVALLNA
                     AQEVELAKRIEAGLYAEHLLATEGNDLEAKYRRELHWVAQDGQRAKNHLLEANLRLVVS
                     LAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQAR
                     TIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAVELDMTPEKVVEVQKYGREPISL
                     HTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHAVLDTLSEREAGVVSMRFGLT
                     DGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLDD"
     gene            10001..11182
                     /locus_tag="E4J16_RS07420"
     CDS             10001..11182
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178451.1"
                     /locus_tag="E4J16_RS07420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_136193248.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.3e-37, bitscore:
                     126.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVDALLPLVRGAVDARLEHVLAKLRSQWHDSTGSAQELFDAAE
                     TAVAGGKRMRAVLGSVGLAMLVQEPDPDGGKAAECGGRRTAVLTGPTATRLGSALELYQ
                     ASALVHDDVIDAAATRRGAPSAHCRFAARHREAGWRGSADGYGVNAAILLGDLLMSAAT
                     SEMGAAASNCDPVGARAARDAFDAMTAEVALGQFLDVHHEVLPLPEPRDHPVQAGAAMR
                     AAALGVVRHKSARYSVMYPLLVGALLGGVDPHGALFKALEVFGEEIGIAFQLRDDALGV
                     FGDPAVTGKPAGDDLREGKRTVLLALTWQRCNDHGRALLSRILTNGAAATDADIAAATG
                     MIHDCGGLAALEDEISAHTRTGLSALAAVPAGLGTNSRDALTALARVLTARRS"
     gene            11271..13319
                     /gene="pknB"
                     /locus_tag="E4J16_RS07425"
     CDS             11271..13319
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749748.1"
                     /locus_tag="E4J16_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_136193247.1"
                     /sec_met_domain="Pkinase (E-value: 4e-47, bitscore: 158.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKDPLIGRLVDARYEIVDRVARGGMATVYRARDRRLDRLVALKL
                     MHPHLADSPDFVARFRREARAAARLSNPGVVAVYDQGSLDGVAYLVMELVEGPNLRDLI
                     AAGPLTVREALGLTAQVLRPLGAAHRAGLVHRDVKPENVLLPADGSVAKVADFGLARAV
                     TEVTQTTTGNVLGTVAYLAPELITTGASAPCADVFSVGVILYELLTGAQPFAADTPIQI
                     AFRNVHEDVPAPSLQLPDLPEPVNALVAEMTRRDPQERLVDADAALARLREVVSALSEA
                     ELAVKRGGATGSVRTQEVLAANAEAARTAMLAADGAEDAPDDDGAPADAATPGAGLRTV
                     SLPIGSIAPDEAAGVRDGTTRSLDRRQAVRAGEQEETAKVARHSARRPRRRALIALGLL
                     AAVGGAGTWYFGAGPGHTVPVPAIAGMTAAEAQSAVEAAGLVWGAPERAYSDTVPADSV
                     ISSSPDAAARLHPGEAVTPVISRGIEQKTVPDVVGSTQDDATDAITEAGLSLGAVTKTY
                     SDSVASGMVISSDPVAGTTVNHSSAVAIVVSLGRQPAVVPDVTGMSVADATTTLEAAGL
                     ELGEQSEAFSDDVASGLVIASSPASGAAGYYHGDSVDVTVSKGPEMVTVPDVSGMSEQE
                     ATTALKNAGLDVEVSRVLGGLFGTAHSTDPAAGESVRKGSKVTLNVV"
     gene            complement(13463..14803)
                     /locus_tag="E4J16_RS07430"
     CDS             complement(13463..14803)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565051.1"
                     /locus_tag="E4J16_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_136193333.1"
                     /transl_table=11
                     /translation="MNELQVPGEAAGWRQHHAAQQPRYPDPQALADAAADLRTRPPLVF
                     AGEVDSLREKMVSASQGRAFVLMGGDCAESFHDNTAINIRLKLQTILQMAAVLTYGAST
                     PVVKIGRMAGQYAKPRSSDTETRDGVTLPSYRGDSVNDHAFTADARIPDPQRMVDAYLR
                     AGTTLNLIRSFTMGGYADLREVHSWNRGFTANPAYKRFESFAEEIDRAMRFMEAAGVDF
                     DALRQVDFYASHEALLLEYEDAMTREDSRSGRLYDTSAHFLWVGERTRGADDAHVALLA
                     GVHNPVGVKIGPTTTRDELLALIDRLNPEGDPGRLSLITRMGADRIRDVLPPLVEIVRA
                     DGRPVTWITDPMHGNTITSDNGYKTRRFDTIMDEVRGFFEVHRSLGTVPAGIHVELTGD
                     DVTEVLGGGEHIDEAGLARRYETLVDPRLNHQQSLEMAFEVAEMLRG"
     gene            complement(14991..16223)
                     /locus_tag="E4J16_RS07435"
     CDS             complement(14991..16223)
                     /EC_number="2.7.1.90"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005985403.1"
                     /locus_tag="E4J16_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrophosphate--fructose-6-phosphate
                     1-phosphotransferase"
                     /protein_id="WP_136193246.1"
                     /transl_table=11
                     /translation="MSIRRVALLTAGGFAPCLSAAVGDLIERYTEVAPDVEIIAYQYGY
                     HGLLTGNYVVIDDEGRKNAGVLRQYGGSPIGNSRVKLTNAKNLVERGLVEEGVDPLAFA
                     AERLREDGVDVLHTIGGDDTNTTAADLAAYLHEHDYDLTVVGLPKTIDNDVVPIRQSLG
                     AWTAAEQGAGFALNVIGEHRSNPRMLIVHECMGRNCGYLTAETARRYHELLKDRQWAPS
                     LGLTKERWDVHAVFVPEAKLDIAAEAERLKAIMDEQGNVNIFLSEGAGVPEIIAEMEAK
                     GEEVQRDPFGHVKLDTINPGQWFARQFADKIGAEKVMVQKSGYYSRASAANEEDLALIK
                     QMCDLAVECALRGEPGVIGQDEENGDQLGAIAFDRIAGGKPFDITQQWFVDLLAELGQN
                     LEPAAPTGGEA"
     gene            complement(16330..20817)
                     /locus_tag="E4J16_RS07440"
     CDS             complement(16330..20817)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E4J16_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_136313655.1"
                     /transl_table=11
                     /translation="MVSYAFIDIGISITKLLLLDSGNGTAAAVVGEVSGLLQRFQRRCE
                     HGAIRALSAETIARDVAAEVPREHEGISDADWSVVGREVAALIDRLTDRQRRDAGFEWE
                     KLRDTLLENGGKTRRARLADESAKQAFDLVLAVACKQVVKRFSNEEALRELLTQMDRID
                     STLSELRSRPAQASKTRVVVAEHADVIQELAPEELEARETEIADLHDFCRDSGRTWYAV
                     EAEMVSGKTALTATLARRPPADAKVISFFVRRIGGDGNDRERFSFVVRAQLADILGEEY
                     VAWTNGPEQPTEFTLQLERAAIACRAAREPQVLVLLVDGIDEDVYFEHADQGGVSSILS
                     LLPRQLPDGIKIITASRPNPRLPEDVLCEAAGSRDVVPLVPSTIARRSINTKSIERFFE
                     NPLAANIGAFLAASGGALTENDLRSLLNIFEPSRKLSLHEVNRCVSSSPGRMLTPVKVE
                     FGNQDVCAYRLGHDAVLRAILREIDSDAASDNGDGDERWWAGVRERALAPYRADIVRWV
                     RDRAERGWSRETPAYMLSEACFDMVASGEGVDAGAVEVLLEPGRYEEIRRRSGTASRVL
                     RVLDREYLKVLDGELPERLVPALHGIAEKRDGILARWRYVPGVLATWVTHLSREAVAVM
                     DIVLAVFEPSARIDALKEVVRAAIESGRGDGFVRLVPEVIDSVVAIPSLRDSVLGCLVD
                     LAVQVYVCAHGTSDCELVDVGIDAIRESLERLDVGEVIQGAGSSPNGNGRGDSASCLVS
                     FAESAAREIRSPSDRARLLVSVARALVDVGGVVRAREVAEEALAAASEFESPSDRAREL
                     VDVARALVDVGGVVRAREVAEEALAAASEIESPSDRARVLVGVVRALVEMGQSGRAREV
                     AEEALAAAREVESPWGPWGRIKALVEVEGALVEMGQSGRARAAAEEALAAAREIESPSD
                     RAWALADVALGLVAAERVEQAGEVADQALAAARESEYLPDRVWALAYVAGALADAGDAS
                     RALAVAREIESPSDRAWALAHVAGALADAGDASRALAVAREIVSPSDRAWALAHVAGAL
                     AAMGDVVQAGEVAEQALVAARQPKKSRDRTVFLVDLARALADAGWAERAREVADQALAA
                     VREINKQSGFRAVLLMNMARASALVGDVVRAREVAEEALATAHQIESSSDRVKALAFMV
                     GALAGVARALADVGGVVRAREVAEEALATAHQIESPWDPWSRIDVLADVARALVDVGGV
                     VRAREVAEEALATAHQIEEPWDPSGRIDVLADVARALVDVGDVVRAREVAEEALAAASE
                     IEYPPGRARALVDVARALAEMGQSGRAREFAEEALAAARESEYPSDRGRLLVDVARALA
                     EMGQSGRAREVVEEALAVAQKTDFALLMDRALALARALSIVIQGLVREGDVEAAEALFK
                     GQIVRAVEIESSEASRSYLGTLAEAGVEVAQSHVADPEAYEGWLSLARSAIARSWLYGA
                     PVFERFDVLACVAPEFATRLVDERLLAEDHGEAV"
     misc_feature    complement(18565..18567)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18901..18903)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 atcgcggcgt ggacgatgac gtcgacgcgg cgggaccgca gctcgcgcac cgcgcggcga
       61 gtctgttccg cctgcccgcc cgagtcggtc agcagcacgg cccagccgag ctgccgacac
      121 accgtgagaa tggcatcgat catcgccacc gcgtatggcg tggacaggac ccgttctcct
      181 agaaccccga cggtgcgggt gcggcggtta cgcatgccgc cggcgagggc gtcacgcacg
      241 tagccgagtt cttccgccgc cgcccgcact cgcgccgcag tcgcgtccga gacccgccca
      301 ctagccttgc ccgacagcac cagtgacgcc gtggccgttg agacgcgcgc ggcgtccgcg
      361 acatcggcga gagtcgccat cgcccctcct gtcagcacct gagtcaccgg gcgacttcgc
      421 ccgacagcaa gagtgtgcgc cgtcacacga cgttaagtca atcgattaac gtcacagctg
      481 catatacggc gcgttgggtg cgtgtcccgc tggttcagac ggcggtcgcc gcccagctgc
      541 gcgccccgcg caccaaccgc tcgagcccgt cctccacgcg ggcgcgctgg gcgccccacc
      601 gacagcggcc gcgcctacac ggtcggaccg tcctccacgc gggcgcgctg ggcgcccagg
      661 ttcatgcgca ggaagccggc tccggccgcc ccatatgcgg tgccgggcgt gagcaccagt
      721 ccggtgcggg agcggatgtg ggcggccagg gcggcggtcg catccccggc tgcgccctcc
      781 ggcccgcccg gcccgacgcc gtcggctccc ccgccagtgc ggccggccgc cgcaccgcgg
      841 ccaagcagcg cgcgcacgtc gatccaggac aggtaggtgg cctacgagac cggggcggcg
      901 cagccgggca gttcacccgc caccacctgg gccacccgcg ccttattggc ggcgatgtag
      961 gcgcgcgcct gctccaacca ggtcctcaag cgtgatctcc cggcagctcc acagggtctc
     1021 ttcggcgtgg ggcagctcca cgcgccgcag gctgatgccg cggccgcggc ggaaggtctt
     1081 gggggcggcc accagggtcc cgtccaggcg gatgtcgtcg gtgtaccaga tgccggagcg
     1141 ggcggtctcc agcagggcgc cgccactgac cgatacgtcc cggcagtacc acagcggata
     1201 cttccactcg aacacggtgt cgctgatgcg caggccgcgg ctctccttga gcggggactc
     1261 gccgtcggcg aaggtggagt gggagatggt caggtcttgc gcggcataca gtgcgcgttc
     1321 accggtcagg cgacgatggt caaccaccga gccgacgtcg ccgggacaac cgtccggggc
     1381 ctcggcggcg gtgctggggg atgcggtcaa cgtcatggca tccgactgta agcgggcggc
     1441 ctccccgcag cgaggccatg acagtgcccc tcagtcccgg ctcaccaggg ccgcccggat
     1501 caccccccgc gctcggcggg tgggcgtgag cgccgacggc tacacgtcca gtccgtagag
     1561 aatcgtcccc cgggtggcgg tgtagcccag gtcccggaac aggtcaacgg caccactggg
     1621 atcatcggac tcgaagccgg ccgccgcata ctccatgccg tcggcggcgt aggcgcgcat
     1681 gaccgcaccc agcagcgccg ggccgacgtc gcgggagcgg tagtccgcca gcacgccgat
     1741 cacgtcggtg tagccctcac gccagcccag tgccgcccag tcctgctcgt agcggctgga
     1801 gagcacatac ccagccaccc gggccctgtc ccccgaacgg tccatcgcca cgaagctcca
     1861 ctggggagcg aagtaggcgc gccccgcccg ccactcctcc ggcgacatgg ccccgccgcc
     1921 ggagtctgcg aaggcctggt tgtgggcgcg gcggacggcg tcgtcgagct cctccgacca
     1981 cggttcgatg gtgaggaaac catccaggtc gatctcggga atggcgtcag tcagggagcg
     2041 ccgcacctcc cggtaccagc ggcgcggctc gaagcgcagc tccgccaggt ggtccttcat
     2101 gcgctcgtcg tcctccagga cggtggtgac gatgtgcgcg ggggcggttg cggctgcgga
     2161 gccggccacc tcgccggcgc gctcggagcc gatgaggtgg cgcgcccgct cggtctgcca
     2221 gtgcagcagg gccaccccga tgccccgctg ccgccacgcc ggatccaccg tgccggtcat
     2281 ggacgcgtag atctccgccg ccggccgcag ccgtaccagc ccgaaggcac gcataacgcc
     2341 ggtctcatcc cgcccggcca cgccggagta ggtggggtcc acgaagtact cggcggtctc
     2401 ctgagcgctg gtgcggtagg gcggattgtc caccgcctcg gagcgggcga ccagctccgc
     2461 gagctcggcg ttgtcacgtg ggccgagcgg cgcccaggtg agactgcggg gcagcgcgga
     2521 acgggggccg gggcggaaca tggcccacgg gcctcccggg ccggtgcggc gagttgagcc
     2581 gtaaaccgga gtcatctgcg tctccttcga cggggcaggg cccgaccttg ggcatgcgag
     2641 gatcaggcat gcgaggaatt ggctcagacc aggttacccg agcgtacccg gccgcgccgc
     2701 accggcactc gcgccgggcc gcgggacgct gaccgggctc aggcgtcgat gcgctcgcgg
     2761 tctacgtccg cggcaccctc gatgatgaag tcacgccgcg gctccacatt ggatcccatc
     2821 agcagctcga acacgttctc cgcctccgcc aattcggcct cgtcgcgcag ggtgatgcgc
     2881 cgcagcgtgc ggtgctcggg ctccatggtg gtctcggcca gctggtgcgc atccatctcc
     2941 cccaggccct tgtaacgctg tggctccttg aagctgcgcc cctgcttctc cagcttgcgc
     3001 agggtggtga ccagctcctc gtcggagtag gtgtagatga cctcccgctt gcgacggccc
     3061 tgggcggaaa cctcgatgcg gtgcagcggg gggacggcgg cgaagacgcg gccggcctcg
     3121 atcatgggcc gcatgtagcg gaagaagagc gtcagcagca gggtacggat gtgggcgccg
     3181 tcgacgtcgg cgtcggtcat caggatgacc ttgccgtagc gggcggcctc caggtcgaag
     3241 gtgcgcccgg agccggcccc gaccacctgg atgatggcgg agcactcggc gttgcgcagc
     3301 atgtccgcct gggaggcctt ctgaacgttg aggatcttgc cgcggatggg cagcagcgcc
     3361 tggaactcgc tgttgcgcgc gttcttggcg gtgcccaggg cggagtcccc ctcaacaatg
     3421 aacagctcgg aggaggcgac gtcgtcggag cggcagtccg ccagcttcgc gggcagggtg
     3481 gaggtctcca gcgcggtctt gcggcgggtg atctccttgt gcatgcgggc ggagacgcgg
     3541 gcgcgcatct ccccgacgat cttctcctgc agtgcgcgcg actgggtctt caggtcgcgc
     3601 ttggaggagg tcagcagcgc ggtgagctcc ttctccacca ccttggcgac gatctgccgc
     3661 acgggtgcgg taccgagcac ctccttggtc tgcccctcga actgcggctc gggcacgcgc
     3721 acggtgatga cggcggtcat cccggcgagg atgtcgtcct tctcgatgcg cccgtcgcgg
     3781 ctggtgacct tcagggcgcg ggagttggcg tcgatctgct tgcgcagcac cttggtgacg
     3841 gcctgctcga agccggccag gtgggttccg cccatggggg tggcgatgat gttgacgaag
     3901 gagcgctcgg tggtgtcgta gccgatgccc cagcgcaggg cgacgtcaac ggtgcaggtg
     3961 cgctccacct cggtggggcg caggtggccg gtgcgcttgt cgagctgctg cacggtctcg
     4021 gtataggtgc cctcgccggt caggcggaag gtgtcggtga cggagccgtc ggtggccagg
     4081 aagtcgacga agtcggcggt gccgccctcg gcatggaagg tctccgtgct ctcctcgtcc
     4141 ggggcgccgg aggtgaacag gtctccggcg ggcgctgcgg tgtgcgcggc cttggcgctc
     4201 agggccgggt ccgcggcggt cggaccggag gccgtggcgg cgctcgtctc cgggtcgcgt
     4261 tcgtcagtca gggtgagggt gagcccgggc accaggaagc tggtctgccg cagccgggcc
     4321 cgcagggcgg tgacgtcgta ctggtccggg gcggggaaga tctcggggtc ggcccagtag
     4381 cgcacccggg tgccggtgac gccccggcgc accttgccga tcacgcgcag ctgggtggcc
     4441 tcggtgtatt cctcgaaggg tgcggcgggg gtcgggccag tcgaaggatc ggagaagaca
     4501 ccgggcacgc cgcggcggaa gctcatggcg taggtcttgc cgccgcggtc cacctccaca
     4561 tccatgcggg cggacagggc attgaccacg ctggcgccca caccgtgcag gccgccggcg
     4621 gagccgtagg agccgccgcc gaactttccg ccggcgtgca gcttggtgta gaccagctcc
     4681 acaccggtca gcccggagga gggctcgatg tctacgggca cgccccgccc ggtgtcgcgc
     4741 acctcgatgg acccgtcggc gtggacgacg acggcgatgc ggtccccgta gccctccagg
     4801 gcctcgtcca caccgttgtc gatgatctcc cacacgcagt gcatcaggcc ccgctggtcg
     4861 gtggagccga tgtacatgcc cgggcgcttg cgtacagcct cgagcccctc cagcacggag
     4921 aggtggcggg cggaatatga ctgggaggag tccggcacgg ctgaaatcta gccgataacg
     4981 gcagtaggac cggcatcccg cgccgccgcc gcgggtgtgg cattcgtccg caaccgggat
     5041 cggccgggtt ggcacccggt tactgctcgg ggcacgattc ccgccgttcg ccgtgggcgc
     5101 agggggtgcg cccggggcgg aaaacggccg ttaggcgttg gcgctggcgc ccggcgatgg
     5161 tggaatcggg ccatgagcac gacaactcct atgtccccca cggtcgccgc acgggcggct
     5221 gcacctgagc aggccgtcgg cccggcccag gcgaccgagg cgcgtccgct caccaccgcc
     5281 gatcgttgcg acgtgtgcgg tgcacaggcg tacctgcgcg tggtcctcgc ctccggcgag
     5341 ctgctgttct gcgcccacca cggccacgcg caccaggagg ccctggagcg ccaggccctg
     5401 ttcattcagg atgagtccga ccgcctgacc cgccccgccg aggtcgactg accgactgga
     5461 cgggcggcgc gcctgccgga tcctgcctct taccgcctac gccctctggc cgactcggcc
     5521 agagggcgta gtagtggtgc acggggccgt gcccgtggcc gacggtgagc ccgtccgcgt
     5581 gggccagtgc gccagacagg taggtcttcg cctcccttac cgccgtgatc cagctgtccc
     5641 gctgtgggcg cagtgcggca atcgccgcgg agagcgtgca gccggtgccg tgcgtgttgt
     5701 cagtgttcac acggggaccg ggcagcagca ccgtgccctc ggcatccgcg tacacatcgc
     5761 tggcctcccc cagcaggtgc ccacccttga gcagtacccg gcgggcccct gcggcaagca
     5821 gcagttcggc ctggcggcgc atctcgtcgg tgtccgctgc cggggcccgt cccagcaggg
     5881 cggcggcctc gggcaggttc ggggtgatca ggtccgctcg cgcgcacagg cgcctgacgg
     5941 catccatggc cgcggcgtcg agcagccggt ccccggaggt ggccaccatc accgggtcca
     6001 ggaccgtgtt ggccatccgc gccaggtact cccccaccgc ctcggcagtc tccgaggtgg
     6061 cgagcatgcc gatcttggtg gcgtcggggc ggatgtccac caggagggtg tccagttgca
     6121 ggcgcacaaa gcccgctgga accgtgtgca cgccggtcac gccgcgggtc gactgggcgg
     6181 tcagtgccgt caccacgctc atgccgtagg cgcccagcgc ccccatggtc ttcaggtcgg
     6241 cctggatgcc ggcgcccccg gaggggtcgg agccggcgat ggtcagcacc ttgggcaccg
     6301 gggcgccgca ggacggggcg tccaccacgc acgcgggtgt tacgtcgctc attgacccga
     6361 ctcccaggcc cggcgcagcg cgcgggcggc cgcgcgcgga tcgtccgcca gacagatggc
     6421 ggacacgacg gcggccccgg ccagtccccc ggcgcgcagg gcgggcaggt ccgccgcggt
     6481 gacgccgccg atggccacac acggcaggtc ggtaccggcg gccaggcggg cgatgccagg
     6541 tgctcccaga ccggcgggcg catcgggttt agtagtggtg gcacgcaccg caccgatgcc
     6601 cacgtggtcg caggcgccct cggcctgcgc cgtagccagc tccgcgggcg tggcggcgga
     6661 caggcccagg taggcgtcat caccgatgag ctcacgtacc accgcagcgg gcaggtcgcg
     6721 ctgtcccacg tgcacgccag ccaccggcgc gccgagccgc cgggccgcga ggaacacgtc
     6781 tacgcggtcg ttgacgatca ccgggacctg gcggccgacg gcgtgggcga cgtcgagcac
     6841 ctgggtgagg aagtcggcgc cgtcggcatg cttggcgcgc acctgcacgc aggtggcgcc
     6901 accggcgacg gcagccctga ccgtgtcggt gacggtgcgg ccgcgggccc ggcactgggc
     6961 ggcatcggtg accaggtaga cccgcaggtc gggggcggct ctcatatcac cgggatcctg
     7021 gcgaggtcgt cggcatccag cgcgtagagg gcgtctagca gggcgatccg gaaggagccg
     7081 ggacccgcgg cggtctcggc ggcgatctcc gcggcggcac tgtatgcggc gtggcacgca
     7141 acggtcgcgg cgccggcgtc ggcccccgag gcgcgtccgg cggcaacgaa tccggccacc
     7201 agcgccccca gggcacaacc gcccccggtc acgcgggtca gcagcgccga gccgccaccc
     7261 acccgggtaa cccgggcgcc gtcgactatc gcgtccatgg gcccggagac ggcgatgacc
     7321 gcgccggtgc gctctgacag tgaccgggcg gcgtccaggg cggcctccac gtcgtcggcg
     7381 gagtccacgc cccggccgcc cgctccggag cctgccaggg cgatgatctc cgaggcgttg
     7441 ccgcggatga cggtcggggc ctcatcaagg agccggtggg ccagcgcagt gcgatgcacc
     7501 agcgtaccga ccgcaaccgg gtccagcacc cacgggacgc ccgccgcccg tgcggcggtg
     7561 gcggcctcca cggcggctga gcgctgctcg ggctggggcg tgcccaggtt gatcagcagg
     7621 gcgcaggcac cggcggcgaa ggggccggcc tccccggtga cgtccaccat ggcgggggcg
     7681 gcgccgacgg ccagcagcac attggcggtg aagttcgtga ccaccgcgtt ggttatgcag
     7741 gccaccagcg gcccggtgga gcgcagggac tccagtacct ccacggcgcc cgggggcggc
     7801 gccggcactc tcaagatcga gggttcggcc gggcggtcgt tcggatgggt gtttgcgtgc
     7861 gcgcgctgcg tcatgcgaca tcccttcgtc agcattatct ggacaggttc aacgggtttg
     7921 ttctcagcct tgcggcaccc cgtgtcgtgc ggccaacaat agcaagcaga cggccgcccc
     7981 ggaaccggtc ggttccgggg cggccgagcc gtgtagggac gagggcttgc cgtcgcctca
     8041 gtcgtccagg tagtcgcgca gcacctggga gcggctgggg tggcgcagct tgctcatggt
     8101 cttggactcg atctgcctta tacgctcgcg ggtcacccca tagaccttgc cgatctcgtc
     8161 cagggtcttg ggctggccgt cggtcaggcc gaagcgcatg gagaccacgc ccgcctcccg
     8221 ctcggacagg gtgtccagga cggcgtgcag ctgctcctgc agcagcgtga agctgacggc
     8281 gtcggcgggg acgaccgcct cggagtcctc gatcaggtca ccgaactcgc tgtcgccgtc
     8341 ctcaccgagc ggggtgtgca gggagatggg ctcgcgcccg tacttctgca cctcgacgac
     8401 cttctccggc gtcatgtcca gctcgacggc gagctcctcc ggggtgggct cgcggcccag
     8461 gtcctgcagc atctgccgct ggacgcgggc gagcttgttg atgacctcga ccatgtggac
     8521 ggggatgcgg atggtgcgcg cctggtccgc catggcgcgg gtgatggcct ggcggatcca
     8581 ccaggtggcg taggtggaga acttgtagcc cttggtgtag tcgaacttct ccaccgcacg
     8641 gatcagaccc aggttgccct cctggatcag gtccaggaac agcatgccgc ggccggtgta
     8701 gcgcttggcc agggagacga ccaggcgcag gttcgcctcc agcaggtggt tcttggctcg
     8761 ctggccgtcc tgcgccaccc agtgcagctc acgacggtac ttggcctcaa gatcgttgcc
     8821 ctcggtggcc agcaggtgct cggcgtacag gcccgcctcg atgcgcttgg cgagctcgac
     8881 ctcctgggcg gcgttgagga gggcgacctt accgatctgc ttgaggtagt ccttgaccgg
     8941 gtccgcggtg gcaccggcgg tgacgacctt ctgagcgggc tcgtcgccct cgtcggagtc
     9001 ggagaccgtg aaggatccgt ccttgctctt ctccccggtc ttggccttct tggacttctt
     9061 gcccgcggtc ttctccgcct cctcccggcg caggcggtcc agctcgccgg tcagcgccgc
     9121 gatggacggg ttcatcttga tgcccttgat gatccagccg cggaagatga acccgttctt
     9181 ggtgaggaac tcgcgggcga ccacgggctc ctcctccccg gggaccacga agcgcggcac
     9241 cggaccgtgc ccgtagggag ccagggtgat cggctcatcc agggtgccgt cgccggagat
     9301 ctccaggccc tcgacgaccg tccggctgcg tacgaacagc gtggcgccgg gggcgagccg
     9361 cacgctcttc agcgcagcgg gagtgttgaa tgggtggcgc ttggttccgt cgccgttctc
     9421 ctcgagcgag acgtccaggt agtagtcgcg cagctcgggc gcgggggcgg cagcctcctc
     9481 ggactccccg gcgtcctcat cggaatcgtc ctcggcgtcg tcctcgtcat cggcctgcgc
     9541 cgagtcggcg tcgtcgtagt cgtcctcacc gtcgtagtcg tcctcggcat cgaggtcgtc
     9601 ctcttcgtcc aggtcgtctt ccgcatcaag ctcgacgtcc tgtctgtcct cgaggacctc
     9661 gtcgacgtcg tcagcgagtt cgacacgctc ccgcctggtc gtaggagcag gagcaactgt
     9721 ggaagtagcc acggatttcc tttcacgggg cggacggttc agccggagtg gcgcacagag
     9781 tcttgagcaa gtctacgcga ggatcccaag cgggcccgca ggcgtgcgcg cagcgcgcga
     9841 atgggctccc cgcaggacga cccgacaaga cctaggcatc cgcccccagc gcgaagagca
     9901 acgaccggtg ccgcccagat attcccgcgc ccatcgcgca ccgtggccga gtacccggat
     9961 tccgacggaa cccgcgcagc cgatcatcta gcctgggctc atgaccgacg ttgacgcact
    10021 gctgccgctc gtacgcggcg ctgtggacgc gcgcctcgag cacgtactgg cgaaactgcg
    10081 ctctcagtgg cacgactcga ccggctccgc ccaggagctg ttcgacgccg ccgaaaccgc
    10141 ggttgccggc ggcaagcgca tgcgcgcggt gctgggatcc gtgggcctgg ccatgctcgt
    10201 acaggagccg gaccccgacg gcggcaaggc cgctgagtgc ggtgggcggc gcaccgctgt
    10261 actcacgggc ccgacggcga cccggctggg atcggcgctg gagctgtatc aggccagtgc
    10321 gctcgtacac gacgacgtca tcgacgccgc cgccacccgt cggggggcgc cgtccgcgca
    10381 ctgccgcttc gccgcccgcc accgcgaggc cggctggcgc ggttccgccg acggctacgg
    10441 cgtgaacgcc gccatcctcc tgggcgacct gctcatgtcc gccgccacga gcgagatggg
    10501 tgcggccgcg tccaactgtg accccgtcgg cgctcgggcc gcccgggacg ccttcgacgc
    10561 catgaccgcg gaggtcgccc tcggccagtt cctggacgtg caccatgagg tgctgccact
    10621 tcccgagccg agggatcatc cggttcaggc gggtgcagcc atgcgtgccg cggcactcgg
    10681 ggtggtgcgg cacaagtcgg cgcgctactc ggtcatgtac ccgctgctcg tcggcgccct
    10741 gctcggcgga gtggaccctc atggcgcgct tttcaaggcg ctggaggtct tcggcgagga
    10801 gatcggtatc gccttccagc tgcgcgacga cgccctgggg gtattcggag accccgccgt
    10861 gaccgggaag ccggccggag acgacttgcg cgaggggaag cggacagtgc tgctcgccct
    10921 gacctggcag cggtgcaatg accacggccg ggcactgctg agccgaatac tgacgaacgg
    10981 ggctgcggcc acggatgcgg acatcgccgc ggccaccggc atgattcacg actgcggcgg
    11041 cctggcggcg ctggaggatg agatcagcgc tcacacgcgc acgggcctga gcgccctcgc
    11101 ggcggtcccc gccgggctcg gcaccaactc ccgggacgcg ctcactgcac tggcacgggt
    11161 gctgaccgcc cggcggagct gatgccggcg ccgctgaccg atccgctgac gcggacggcg
    11221 ccaggccgcg taacgcgtcg gtgggcgtcc ttgcccgtac actcgacccc gtgaccaagg
    11281 atcctctcat cggccgcctg gtcgacgctc gctacgagat cgtcgaccgg gtggctcgtg
    11341 ggggcatggc caccgtctat agggcgcggg accggcgcct ggatcgcctg gtggcgctca
    11401 agctcatgca cccgcacctg gcggactccc ccgacttcgt ggcccgcttc cggcgcgagg
    11461 cccgggcggc ggcgagactg tccaacccgg gagtggtggc ggtgtatgac cagggcagcc
    11521 tggacggggt cgcctacctg gtgatggagc tcgtggaggg ccccaacctg cgcgacctga
    11581 tcgccgccgg ccccctgacg gtgcgtgagg cactcgggct gacggcccag gtgctcaggc
    11641 cgttgggggc cgcccatcgc gccggcctgg tccaccgcga cgtcaagccc gagaacgtgc
    11701 tgcttcccgc cgacggctcg gtggcgaagg tcgccgactt cggtcttgcg cgcgcggtca
    11761 ccgaggtcac ccagacgacc accgggaatg tgctcggcac ggtcgcatac ctggcgccgg
    11821 agctgatcac cacgggcgcc tccgccccgt gcgccgacgt cttctccgtg ggcgtgatcc
    11881 tgtacgagct gctgaccggc gctcagccct tcgccgcaga cacccccatc cagatcgctt
    11941 ttcgcaatgt gcacgaggac gtgcccgcgc cgtcgctgca gctgccggat ctacccgagc
    12001 ccgttaacgc cctggtggcg gagatgaccc ggcgcgaccc gcaggagcgg ctggtcgacg
    12061 ccgatgcggc gctggcgcgc ctgcgggagg tcgtctccgc gctgagcgag gccgagctcg
    12121 cggtcaagcg cgggggcgcg accggttcgg tgcgcaccca ggaggtactg gccgcgaacg
    12181 ccgaggccgc ccgcaccgcg atgctggcgg cggatggggc cgaggacgct cccgacgacg
    12241 acggtgcgcc tgcggacgcg gccacgccgg gcgccgggct gcgcacggtc tccctgccca
    12301 tagggtccat cgcccccgac gaggccgcgg gcgtgaggga cgggaccacc cgctccctgg
    12361 accgccgcca ggccgtccgg gcaggcgagc aggaggagac cgcgaaggtg gcacggcact
    12421 cggccaggcg tccacgccga cgcgcactga tcgcgctcgg cctgctggct gcggtcggcg
    12481 gggcgggtac ctggtacttc ggagcaggac cgggtcacac cgttccggtg ccggccatcg
    12541 ccgggatgac ggcggctgag gcgcagagcg ccgtggaggc cgccgggttg gtgtggggcg
    12601 cccccgagcg cgcctactcc gacacggtgc ccgcggactc agtgatctcc tcctcccccg
    12661 atgccgccgc ccgcctgcat ccgggcgagg cggtcacccc ggtgatctcc cgtgggattg
    12721 agcagaagac cgtgcccgac gtcgtcggct ccacgcagga cgacgccacc gacgccatca
    12781 ccgaggcggg cctgtcactc ggcgccgtca ccaagaccta ctccgactcg gtcgcctccg
    12841 gcatggtcat ctcctccgat ccggttgccg gcaccaccgt caaccactcc tccgccgtcg
    12901 caatcgtggt gtcgcttgga cggcagcctg ccgtggtccc ggacgtgacc ggcatgagcg
    12961 tggcggacgc cacgaccacg ctggaggctg ccggccttga gctgggtgag cagtcggagg
    13021 ccttctccga cgacgtcgcc tcaggcctgg tgatcgcatc aagccccgcc tccggcgccg
    13081 caggctacta ccacggagac tccgttgacg tgaccgtgtc caagggaccg gagatggtca
    13141 cggtgccgga cgtctccggc atgagcgagc aggaggcgac caccgccctg aagaacgcgg
    13201 gactggacgt ggaggtctcc cgggtgctgg gaggactgtt cggcacggcc cactccaccg
    13261 acccggcagc cggtgagagc gtgcgcaagg gctccaaggt caccctgaac gtcgtctgag
    13321 ctcccgcccg caggcggcaa tttctcaacg tcgacgtcgg cggggcctgc gggcggcaaa
    13381 caccccaccc gcgggcggac gcaccaggat gaccggggac gcggagttga cccacctcca
    13441 cggcgggact gaggcgagtc cctcagcccc ggagcatctc cgcaacctcg aaggccatct
    13501 ccagggactg ctggtggttc agccgggggt ccacgagggt ctcgtagcgg cgggccaggc
    13561 cggcctcgtc gatgtgttct ccaccgccga ggacctcggt gacgtcatcg ccggtgagct
    13621 ccacgtgaat gcctgcgggc acggtcccca gggagcggtg cacctcgaag aagccgcgta
    13681 cctcgtccat gatcgtgtcg aaccgacgag tcttgtatcc gttgtccgag gtgatcgtat
    13741 tgccgtgcat ggggtcggtg atccaggtga cgggccgccc gtcggcgcgg acgatctcca
    13801 ccaggggcgg cagcacgtcc cggatgcggt cggcgcccat gcgggtgatg aggctgagcc
    13861 tgccgggatc gccttcgggg ttgagccggt cgatgagcgc aaggagctcg tcgcgggtcg
    13921 tcgtcggccc gatcttgaca ccaacggggt tgtgcacgcc tgccagcagg gcgacgtggg
    13981 cgtcgtcggc gccgcgagtg cgctccccca cccacaggaa gtgggccgag gtgtcgtaca
    14041 ggcggccgct acgcgagtcc tcgcgtgtca tggcgtcctc gtactccagg agcagggcct
    14101 catgagacgc atagaagtcg acctgccgca gggcgtcgaa gtcgactccg gcggcctcca
    14161 tgaagcgcat ggcccggtcg atctcctcgg cgaaggactc gaagcgcttg tatgcgggat
    14221 tggcggtgaa gccccggttc caggagtgga cctcacgcag gtcggcgtag cctcccatgg
    14281 tgaaggaccg gatgaggttc agggtggtgc cggcacgcag gtatgcgtca accatgcgct
    14341 gcgggtcggg gatacgggca tcggcggtga aggcgtgatc gttgacggag tctccgcggt
    14401 aggagggcag cgtgacgccg tcccgggtct ccgtgtccga gctgcgcggc ttggcgtact
    14461 ggccggccat gcggccgatc ttgaccaccg gggtggaggc gccgtaggtg agtacggcgg
    14521 ccatctgcag gatcgtctgc agcttcaggc ggatgttgat cgcggtgttg tcgtggaagg
    14581 actcggcgca gtcaccgccc atcagcacga atgcgcgccc ctgggatgcg gacaccatct
    14641 tctcgcgcag cgagtcgacc tccccggcga ataccagcgg cggacgggtg cgcaggtcgg
    14701 ccgcggcgtc ggcgagcgcc tgcgggtccg ggtaacgggg ctgctgggcg gcgtgatgct
    14761 gacgccagcc ggccgcctca ccgggaacct ggagctcgtt catcatggcg ccagcatagg
    14821 cgagcgccct ctccagctgg ggcccgcgcc gaaaggtggg acgcagcgca cgccgtcggc
    14881 cgcgctcccc tgccgcgact cgttgcgcgc agcgagctca gaaggggtcg ggcgaacgcg
    14941 ttctcctgcg cccgcccgac ccctattagc cggttggctg agcctgcggc tcaggcctcg
    15001 ccgccggtgg gtgcggcggg ctcgaggttc tggccgagct cggcaagcag gtcgacgaac
    15061 cactgctgag tgatgtcgaa gggcttgccg ccggcgatgc ggtcaaaggc gatggcgccg
    15121 agctggtcgc cgttctcctc atcctggccg atgacgccgg gctcgccgcg cagcgcgcac
    15181 tcgacggcga ggtcgcacat ctgcttgatc agggccaggt cctcctcatt ggcggcggat
    15241 gcgcgcgagt agtagccgga cttctgcacc atgaccttct cggcgccgat cttgtcggcg
    15301 aactggcggg cgaaccactg gccggggttg atggtgtcga gcttgacgtg gccgaagggg
    15361 tcgcgctgga cctcttcacc cttggcctcc atctccgcga tgatctcggg gacgccggcg
    15421 ccctcggaca ggaagatgtt gacgttgccc tgctcgtcca tgatggcctt gaggcgctcg
    15481 gcctcggcgg cgatgtccag cttggcctcc ggcacgaaga cggcgtgcac gtcccagcgc
    15541 tccttggtga gccccaacga gggcgcccac tggcggtcct tgagcagctc gtggtagcgg
    15601 cgggcggtct cggcggtgag gtagccgcag ttgcggccca tgcactcgtg gacgatcagc
    15661 atgcgcgggt tcgagcggtg ctcgccgatt acgttgagag cgaagccggc accctgctcg
    15721 gcggcggtcc aggcgcccag cgactggcgg atcgggacga cgtcgttgtc gatcgtcttg
    15781 ggcaggccga cgacggtgag gtcgtagtcg tgctcgtgca ggtaggcggc caggtcggcg
    15841 gcggtggtgt tggtgtcgtc accgccgatg gtgtgcagca cgtcgacgcc atcctcgcgc
    15901 agccgctccg cggcgaaggc gagcgggtcc acgccctcct caaccaggcc gcgctcgacc
    15961 aggttcttgg cgttggtgag cttgacgcgg gagttgccga tcggggagcc gccgtactgg
    16021 cgcagcacgc cggcgttctt gcggccctcg tcgtcgatga cgacgtagtt gccggtgagc
    16081 aggccgtggt agccgtactg gtaggcgatg atctcaacgt cgggggcgac ctcggtgtag
    16141 cgctcgatga ggtcgcctac ggcggcggac aggcaggggg cgaagccgcc cgcggtgagg
    16201 agggcgacgc gacggatcga catcggaaac ctttcgtagg tggtggggca tgtcgcggcc
    16261 atcctatcgg gatgccgccc ccgcgcgccc ggaatcagac cgagcagaag cctccggcaa
    16321 cgaatgaggt cacaccgcct caccatggtc ctcggcgagc aggcgctcgt cgactagccg
    16381 cgtcgcgaac tcgggggcga cgcacgccag cacatcgaag cgctcgaaca caggtgctcc
    16441 atacagccag ctccgagcaa tcgcagagcg cgccaggctg agccacccct catatgcctc
    16501 cgggtcggcg acatggcttt gagcgacttc gacgccggcc tcggcaaggg tacccaagta
    16561 ggaacgactg gcttcagaag actcgatctc aaccgctcgg acaatttgcc ccttgaatag
    16621 agcttcagct gcctcgacgt ccccctcacg tacaagtcct tgaatcacta tcgacagcgc
    16681 gcgagccagc gcaagagccc gatccatgag cagggcgaag tcagttttct gcgcaacggc
    16741 caacgcctcc tcgacgacct cacgtgcccg cccgctctgt cccatttccg ccagcgcccg
    16801 cgccacatcc accagcaggc gcccccgatc cgaaggatac tcgctctcac gcgcagcggc
    16861 caacgcctcc tcggcaaact cacgcgcccg cccgctctgt cccatttccg ccagcgcccg
    16921 cgccacatcc accaacgcac gcgctcgccc cggaggatac tcgatctcac tcgcagcggc
    16981 caatgcctcc tcggcaacct cacgcgcccg cacaacatca cccacatcca ccaacgcacg
    17041 cgcaacatcc gccaacacgt caatccggcc cgacggatcc cagggttcct caatctgatg
    17101 tgcagtggcc aacgcctcct cggcaacctc acgcgcccgc acaacaccac ccacatccac
    17161 caacgcacgc gcaacatccg ccaacacgtc aatccggctc cacggatccc agggagactc
    17221 aatctgatgt gcagtggcca acgcctcctc ggcaacctca cgcgcccgca caacaccacc
    17281 cacatccgcc aacgcacgcg ccacacccgc caacgcaccc accataaacg ccaatgcctt
    17341 cacccgatcc gaggaagact caatctgatg tgcagtggcc aacgcctcct cggcaacctc
    17401 acgcgcccgc acaacatcac ccacaagcgc cgaagcacgc gccatgttca tcaacaacac
    17461 tgcccggaaa ccagactgct tgttgatctc acgcacagca gccagcgcct ggtcggcgac
    17521 ctcacgcgct cgctcagccc accccgcgtc ggccagcgca cgggccaaat ccaccaaaaa
    17581 cacggtccgg tcacgagact tcttgggttg acgcgcagca accaatgcct gctcagcaac
    17641 ctcacccgcc tgcacaacat cacccatagc tgccagcgca ccggccacat gcgccaacgc
    17701 ccacgcccga tccgaaggag acacgatctc acgcgcaaca gccaacgctc gagaagcatc
    17761 acccgcgtcg gccagcgcac cggccacatg cgccaacgcc cacgcccgat ccgaaggaga
    17821 ctcgatctca cgcgcaacgg ccaacgctcg agaagcatca cccgcgtcgg ccagcgcacc
    17881 ggccacatac gccaaagccc acacccgatc cggaagatac tcgctctcac gcgcagcggc
    17941 caacgcctgg tcggcgacct cgcccgcctg ctcaacccgc tccgcagcta ccaagcccag
    18001 cgccacatcc gccaacgccc acgcccgatc cgaaggagac tcgatctcac gcgcagccgc
    18061 caacgcctcc tcggcagccg cacgtgcacg cccgctctgt cccatttcca ccagcgcccc
    18121 ctccacctca accaacgcct taatccgacc ccacggaccc cagggagact cgacctcgcg
    18181 cgcagcggcc aacgcctcct cggcaacctc acgcgcacgc ccgctctgtc ccatttccac
    18241 cagcgcccgc accacaccca ctagcacccg cgcccgatcc gaaggtgact cgatctcact
    18301 cgcagcggcc aacgcctcct cagcaacctc acgcgcccgc acaacaccac ccacatccac
    18361 caacgcacgc gcaacatcca ccaactcccg cgcccgatcc gaaggtgact cgaactcact
    18421 cgcagcggcc aacgcctcct cagcaacctc acgcgcccgc acaacaccac ccacatccac
    18481 caacgcacgc gcaacactca ccaacagccg tgcccgatcc gaaggagacc tgatctcacg
    18541 cgcagcactc tcagcaaaag agactaagca ggacgcactg tctccgcgcc cattcccatt
    18601 aggcgagctc ccagcacctt ggattacctc gccgacgtca aggcgctcaa gagactcccg
    18661 tatggcgtca atcccaacat caaccaattc gcagtcactc gttccatgcg cacacacgta
    18721 aacctgaacc gcgagatcca caagacatcc caggaccgaa tcgcgaagcg aaggaatcgc
    18781 taccacagag tcgatcacct cgggcaccaa gcgaacgaaa ccatctccac gacccgactc
    18841 gatcgcagcc ctgacaacct ccttcaaagc atcaattctc gcactcggtt caaagaccgc
    18901 taaaactatg tccataaccg ccacagcttc tcgactaaga tgcgtcaccc aagtcgccaa
    18961 taccccggga acataacgcc aacgagctag gatgccatcg cgcttttcgg cgattccatg
    19021 aagtgcggga accagtcgtt ccggtagttc accatcgagc accttcaggt attcccggtc
    19081 aagcacccgc aataccctcg aagccgtgcc ggaacgtctg cggatctcct cataccgacc
    19141 cggctcaagc agcacctcaa ccgccccagc atccacaccc tcgccggacg ccaccatatc
    19201 gaaacaagcc tcactcagca tgtaggccgg cgtctccctc gaccaccccc gttccgctcg
    19261 atccctgacc caacgcacga tatccgcgcg gtaaggagca agcgcccgct cacggacccc
    19321 ggcccaccag cgctcatcgc catccccatt gtcactggca gcgtcagaat cgatttcccg
    19381 gagaatcgcc ctcagcacag cgtcgtgccc caggcgatag gcacacacat cctgattgcc
    19441 gaattccact ttgaccggag taagcatgcg cccaggcgaa ctgctgacac accgattcac
    19501 ctcatgcaag gaaagtttcc gactaggttc aaatatattc agcaatgagc gcaggtcatt
    19561 ctccgtgagg gccccgccgc tggcagcaag gaaagcgccg atgttcgctg cgagtgggtt
    19621 ttcgaaaaac cgctcaatgc tctttgtatt gatgctccgt ctcgcgatag tagaggggac
    19681 cagcggcaca acatcgcgac tccccgccgc ctcacacagc acatcctccg gcagccgggg
    19741 gttggggcgg gaagcggtga taatcttgat tccatccgga agctggcgcg gaagcaatga
    19801 caaaatagag gacacgccac cctggtcggc atgctcgaaa tagacatcct catcaattcc
    19861 gtcaacgagc agcaccaata cctgcggttc gcgggccgca cggcaggcga ttgcggcgcg
    19921 ttccaactgc aaggtgaact cagtcggttg ttcgggacca ttcgtccaag ccacatattc
    19981 ctcgccaagg atatcggcaa gctgggcgcg gaccacgaag gagaaccttt cgcggtcgtt
    20041 cccgtcgcca ccaatacggc gcacgaaaaa ggagatcact ttcgcgtccg ctggcggcct
    20101 gcgagccaag gttgccgtaa gcgctgtttt gccgctgacc atttccgcct ccaccgcata
    20161 ccaagttctg ccggagtcac ggcagaagtc atgtaggtcg gcaatctccg tctcacgcgc
    20221 ctccagctcc tccggagcga gttcttggat cacatctgca tgttccgcaa caaccactcg
    20281 tgtcttcgac gcctgcgcag gacgactgcg cagctcactc aaggtcgaat caatgcggtc
    20341 catctgcgtg agcagttcac gcagcgcctc ctcattactg aaccgcttta ccacctgctt
    20401 gcacgccacg gcgagcacga ggtcaaaagc ctgcttcgcg gactcgtccg ccagcctcgc
    20461 tcgtcgcgtc ttaccaccat tctcaagcag ggtatctcgc aacttctccc actcaaaccc
    20521 cgcgtcacgt cgctgacggt ccgtcagcct atcgatgagc gcggcgacct cgcgtcccac
    20581 caccgaccaa tccgcgtcag aaataccctc atgctcgcgc ggtacctcgg cggcgacatc
    20641 acgagcaatc gtctcagcgg acagcgcccg gatggcccca tgctcgcagc gccgttgaaa
    20701 ccgctggagc agccctgaca cctcgccgac cactgcagcg gctgtcccat ttccggagtc
    20761 gaggagcagc agcttggtga tggagatgcc gatgtcgatg aaggcataag aaaccacggg
    20821 tgctcctcgg ggagtgatgg gcaggtccgg cgccgcgcgg cgtcagtcca cggcatcgtc
    20881 cggcccgccc ggctcgtcgc cccgctccgg ccgctcctcc ggctcggcgg cgtccgagtc
    20941 tacgccctcg ccgtccggct ccggctcggc gccttcgggc tcgtctggct ccgccggcgg
    21001 ctcggggacc tcgacgtcgg gggcggggcg gccgccgggg gcctggaccg gagcggccgc
    21061 cggccgcttg gcggccagct cctcgagcat ctcgttgacg acctcctcgg ccgtcttctt
    21121 ctccgcgtcc atcgccttct tcacgtccgc ggcgtacagg tccacatact cctggccgga
    21181 ca
//
