LOCUS       NZ_ML974127            11812 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Halorussus salinus strain YJ-37-H Scaffold1, whole genome shotgun
            sequence.
ACCESSION   NZ_ML974127
VERSION     NZ_ML974127.1
KEYWORDS    WGS; RefSeq.
SOURCE      Halorussus salinus
  ORGANISM  Halorussus salinus
            Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
            Halobacteria; Halobacteriales; Haladaptataceae; Halorussus.
REFERENCE   1  (bases 1 to 1585202)
  AUTHORS   Cui,H.-L. and Han,D.
  TITLE     Genome sequence of Halorussus salinus YJ-37-H isolated from a marine
            solar saltern
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1585202)
  AUTHORS   Cui,H.-L. and Han,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2019) School of Food & Biological Engineering,
            Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang,
            Jiangsu 212013, China
REFERENCE   3  (bases 1 to 1585202)
  AUTHORS   Cui,H.-L.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2019) School of Food & Biological Engineering,
            Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang,
            Jiangsu 212013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2019
            Assembly Method                   :: SOAPdenovo v. Apr-2019
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004765815.2-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 11:43:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,758
            CDSs (total)                      :: 4,705
            Genes (coding)                    :: 4,661
            CDSs (with protein)               :: 4,661
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 8 of 44
            Pseudo Genes (incomplete)         :: 39 of 44
            Pseudo Genes (internal stop)      :: 6 of 44
            Pseudo Genes (multiple problems)  :: 6 of 44
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:04:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1573390
            Orig. end                         :: 1585202
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            ML974127.1.
            Bacteria and source DNA available from School of Food & Biological
            Engineering, Jiangsu University.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11812
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="7"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..11812
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11812
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:11062](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11062
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(670..1704)
                     /locus_tag="EPL00_RS07890"
     CDS             complement(670..1704)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EPL00_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_135851024.1"
                     /transl_table=11
                     /translation="MATGGRGLSPRLALLVVLLLAAHHGLLDGTESALGASAVLVLALL
                     AAGLLAVLSVAGPVALPTGLVVLTGLLAALDVAPELLVLAGLVARPVGLPTSVLAPGLA
                     NLTARLVGPAALSAGLLSGLLFVTGVLATASAVLTQLVNAAPGLAALPSSLLILADFVT
                     LATLVATGPLLAALVAPVSLALLAPGLLLASLLVSTTLLMLTALLACLLVPTCLLVLTA
                     LLVSRLLVLASPVLALLLLASASVSLALLTTALVLTGLLLASLLLAVLLSELLSARLLL
                     LAGLVAAAGLVLAGQVPLGLPSSGLTSLPPARRVAAASGVTFALRTALVALLLGASPIA
                     AVFV"
     gene            1877..3553
                     /locus_tag="EPL00_RS07895"
     CDS             1877..3553
                     /EC_number="7.1.1.-"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009365902.1"
                     /locus_tag="EPL00_RS07895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit D"
                     /protein_id="WP_135851023.1"
                     /transl_table=11
                     /translation="MSDAPETDPEVGAPARPGVDYDRLEDLLGDRVLGRESHLNAEGFV
                     VRPDAAESVLRTLKDEAGFDHLSLLTAQEYEDRYESIYHLKKYDDPTHEVSVVVPTDPE
                     EPWNRSASSVYKTAEWHEREAYDLVGIEYEGHPDLRRILLPETWQGHPLTDDYDQNKPQ
                     VVTLQKHVNPLAEDARDEESESDTMFLNIGPHHPATHGVLHLKTVLDGEQVADVEPDVG
                     YLHRCEEQMCEQDNYRYQIMPYPDRWDYTANMPNEWAYARTAEALADIEVPEYAQVIRT
                     MATELGRIMGHMLALGTFALDVYGDFTAIFMYAVRDREIVQNILEDLTGQRMMFNYFRL
                     GGVVWDLPEPRDEFFDKIRDFLDGLPQHVEEYHDMMTENEIFQKRTVDTGVISAETAKD
                     YGCTGPVARGSGVDYDLRRDDPYGYYDELDWNVVTEPYGDNYSRVLVRMQEVEESAKII
                     GQCVDMLEDWPEDERNIQANVPRTLKPDPDTEVYRAVEAAKGEMGIYIRSDGTSKPARF
                     KIRSPCFNNLHALEAMAEGEYVPDLVAALGSLDIVLGSVDR"
     gene            complement(3559..4047)
                     /locus_tag="EPL00_RS07900"
     CDS             complement(3559..4047)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021378.5"
                     /locus_tag="EPL00_RS07900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SHOCT domain-containing protein"
                     /protein_id="WP_135851022.1"
                     /transl_table=11
                     /translation="MSPPGDSSSFPRPLARHTPDSSRWRRRVAGIAAVGAVLSLYATFA
                     IVSGVKSGVVYNLLALLFGVLTLVLPVVATTTLFAPDSGLTRGDSSASSSTRTDDSREE
                     RPVETLKRRYAAGEIGQDEFERRLDGVVEADDDLLDGADADSVENPVGRATELDSTGQ"
     gene            4154..5119
                     /locus_tag="EPL00_RS07905"
     CDS             4154..5119
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004215925.1"
                     /locus_tag="EPL00_RS07905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR03557 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_135851021.1"
                     /transl_table=11
                     /translation="MVELGYTLSSEEHGPTDLVSHAVSAEEHGFDFASISDHFHPWIGQ
                     QGHAPFAWATLGGVAAATDDLDVGVGVTCPTVRIHPAILAQATATIATMFEESGQQFYF
                     GVGTGENLNEHVLGDHWPPHDVRLDMLEEAVEVIRKLWTGEMVSHHGDHYTVENAKLFT
                     LPDENPPVCVSAYGDRTASHAADLGDGFWSVGPQDVVETFEEDGGEGPKFSQLTVCYAD
                     DEDEAVETAHEYWPNSLLPGQLATELATPQFFEQACQMVEKEDVREADSIVTDPDPQAH
                     VESVREFVDAGYDHVYVHQIGPEQEEAMEFYEQNVLPEFR"
     gene            complement(5181..5594)
                     /locus_tag="EPL00_RS07910"
     CDS             complement(5181..5594)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005576376.1"
                     /locus_tag="EPL00_RS07910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_135851020.1"
                     /transl_table=11
                     /translation="MSRDHADPERAGQLHHVELYASDLDASVPFWDWLLGELGYEPKND
                     WEAGRSWIRDPTYVVLVRADESDHPFDRDAAGLNHLAFHAASREQVDAITEGVRERDDA
                     GLLFEEQHPFAGGYYALYCEGPEGVKVEVVAPE"
     gene            complement(5664..6224)
                     /locus_tag="EPL00_RS07915"
     CDS             complement(5664..6224)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015763920.1"
                     /locus_tag="EPL00_RS07915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_135852429.1"
                     /transl_table=11
                     /translation="MGRTARLVLAGPVYAALTVVTALLALSAFVLGQNLALAEFALTAP
                     IGLGDRATILFGLYPLLGTNYGPVAEVLLVAIAALAGVDVAMVVYHFREHGVGPSERER
                     AGGGAAGGSTVGLVLGALGAGCAACGSAVLAGLLSLFGVAGAATLLPFDGLEFSVLALV
                     ALVLSIYWVADGMRGGEIRGCPI"
     gene            complement(6293..7117)
                     /locus_tag="EPL00_RS07920"
     CDS             complement(6293..7117)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011223908.1"
                     /locus_tag="EPL00_RS07920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_135851019.1"
                     /transl_table=11
                     /translation="MTDTASRSWTRRRLLGVGGATALGSLAGCIGGRSESEESGASPET
                     TGGTTESTTGATGTATAPLGGHSAAAGLAAQPRFGPPPSEAEGTVVAFEDPSCTRCAAF
                     ERNTVPKIRERLGDRVSFVLRSYPVVYPWGEPATQAIESAFAHEMANSDSDRDPPADAS
                     TAARPGFRQGSEATWALVGHYFETQEQFDTNNVFERTRTFLADETDLDAEAVVADAEEN
                     VHDDAVQADLDAGKKAGVGQTTPTVFLFRGDEFRTSAKGSISFQVVKAALGV"
     gene            7264..8238
                     /locus_tag="EPL00_RS07925"
     CDS             7264..8238
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005043535.1"
                     /locus_tag="EPL00_RS07925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_135851018.1"
                     /transl_table=11
                     /translation="MARDSVLGGGGARRWALALVLASLVLLAGCSGSGGDAAMQATSGQ
                     NLDVSTDAEATQRASDGGGTNSQSDAAARNRALIRTGTVEVTVEDYDDARRNLTRQTER
                     LGGFVSDSAQQVETRGNRTWTNGKLVLRVPKKNFSALVARAKATGEVRAASTSTKDVTK
                     KLVDIEARLTNLKAQREELRDLYAEANDTENVLEVQERLSEVQSEIEQLEAQRKSLNRQ
                     VAYSTLTVRLHERPPEQTAQQSAAWYDTGLVAAFVSSASGVVVVARGLAVGTAYALPYL
                     VAFGLPVVGVVALWRRRSADSSGADLPDAPESPEGGESGEDDD"
     gene            8647..9999
                     /locus_tag="EPL00_RS07930"
     CDS             8647..9999
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004060214.1"
                     /locus_tag="EPL00_RS07930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease J"
                     /protein_id="WP_135851017.1"
                     /transl_table=11
                     /translation="MEIEIATIGGYEEVGRQCTAVRAGDDVVIFDMGLNLSKVLLHDNV
                     ETEKLHSLDLIDMGAIPDDRVMSDLEGDVQAIVPTHGHLDHIGAISKLAHRYNAPVVAT
                     PYTIELVKQQIQGEEKFGVENDLVKMEAGSTMSIGDSGKVELEFVNVTHSIIDAINPVL
                     HTPEGAVVYGLDKRMDHTPVLGDPIDMKRFREIGREGEGVLAYIEDCTNAGRKGRTPSE
                     SVARRHLKDVMTSVEDYDGGIVATTFSSHIARVKSLVEYAHDIGREPVLLGRSMEKYSG
                     TAERLDFVDFPEDMGMFGHRKSVDRTFKRIMKEGKENYLPIVTGHQGEPRAMLTRMGRG
                     ETPYELEDGDKVIFSARVIPEPTNEGQRYQSERLLKMQGARIYDDIHVSGHLREEGHYA
                     MIDALQPQNIIPAHQDMKGFAPYVSLCESQGYELGRDLHVTSNGNLIQLAE"
     gene            10001..11062
                     /gene="idsA3"
                     /locus_tag="EPL00_RS07935"
     CDS             10001..11062
                     /EC_number="2.5.1.81"
                     /GO_function="GO:0044687 - geranylfarnesyl diphosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idsA3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007978760.1"
                     /locus_tag="EPL00_RS07935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="geranylfarnesyl diphosphate synthase"
                     /protein_id="WP_135851016.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.5e-62, bitscore:
                     206.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDASAETLEEQVLGAVEQRREIVNAAIEEDLPVDEPERLYEAVR
                     YLLDAGGKRLRPTVLLLVAEAFADVDATPESIDYRDFPDRDGDSVDVMSAAVAIEVIQS
                     FTLIHDDIMDDDDLRRGVPAVHREYDTETAILAGDTLYSKAFEILVEADADPERVVEAT
                     DVLATTCTNICEGQARDIAFEERPNVVPDEYLEMIKDKTAVLYGAAATIPAILLGADDE
                     TVEELYQYGIDVGRGFQIQDDVLDLTVPSEKLGKQRGSDLVENKQTIITLHAREQGVDV
                     DSLVETDDVESVTEAEIDEAVARLEEAGSIDYAKETAQELVTRGKDRLTVLPENESRDL
                     LEGIADYLIERGY"
     gene            complement(11299..11508)
                     /locus_tag="EPL00_RS23490"
     CDS             complement(11299..11508)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EPL00_RS23490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_202932560.1"
                     /transl_table=11
                     /translation="MWEARTGDEPITDARHEAIAEELRETHLPRLGEADIVEYDERSDV
                     VRYWRQPTLEEYLEHTHYKEFPNE"
     gene            complement(11693..>11812)
                     /locus_tag="EPL00_RS07945"
                     /pseudo=""
     CDS             complement(11693..>11812)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012660235.1"
                     /locus_tag="EPL00_RS07945"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="FREVKRRTSSFSNAFRNAELETAESWLQAFAVWHNSCQT"
ORIGIN
        1 tcgtcaggta gacgatgcgc tcgccgtcgt actccgagag gacggtctcg ctgtccagcg
       61 cgaagtcgtc gtccttcgag aggtggtact gcgcgacttc gccgtggtgg aagcgcgcgc
      121 tcatcccgta gtacgcgaag cccggttcgg gcaccagcac ctcgtcgccg gggtcgagca
      181 tcgcgcgagc gaggtagtcc aacacgccgt cgccgccgtt gccgagccag acctgcgcgg
      241 gcgcgacgcc ccaccggtcg gccaccttct cggtgaggtc ggcgtgggac gccttggggt
      301 aggagtgggc cgaccccgcg gcctcctcga tggcctcgac tgcggccgga ctcgggccga
      361 acgggttctc gttcgacgcg agtttcacga ggtcgtcggg gtctaatccg aggtcgcggg
      421 cgacctcctc gatgccccgc ccggcctgat acacggtgtg cgaagagagg tcccgtggtt
      481 ccatgtgaga gaggtgtagg ccgcccgtct taagactgct tacctccggc gaacgccgcg
      541 gagccgaact ggtagctctc agtccctcga aatcgccgct cccccgacgc cggacggtat
      601 ttttgtcaga atccgcccag tacacataag gaaagtcctg tggtcgctct ggtggggaga
      661 aacacgatgt cacacgaaaa ccgcagcgat tggggacgca ccgaggagca aagccacgag
      721 cgcagttcgc agggcgaagg tgacacccga ggcggccgct actcggcggg cgggcgggag
      781 cgaagtcagt ccggacgacg ggagtccgag cggaacctgc ccggccagca ccagaccggc
      841 cgcggccacg agtccggcca gcaacagcag gcgggccgac agcagttcgg acagcagaac
      901 ggccaacagc agactggcca acagcagacc ggtcagcacc agagcagtag tcagcagggc
      961 aagcgatacg gaagccgacg ccaacagcag gagagccagc accggactgg ccagcaccag
     1021 caagcgggac accaacagag cggtcaacac cagcagacag gtcggcacca gcagacaggc
     1081 cagcagagcg gtcaacatca gcagggtggt ggacaccagc aaactggcca acaacagtcc
     1141 gggagccagc agggcaagcg atacgggagc aaccagcgcg gccagcaacg gaccggtcgc
     1201 caccagagta gccagcgtca cgaagtcggc cagaatcagg agcgaggagg gcagagccgc
     1261 cagtccggga gcggcgttca ccaactgagt caacacggcg gaagcggtgg ccagtactcc
     1321 ggtcacgaac agcagtccgg acagcagacc ggccgacaga gcggccggac cgaccagtcg
     1381 agcagtcaga ttggccagtc cgggagccag cacggaggtc ggcagtccga ccggacgagc
     1441 caccagtcca gccagcacca gcagttcggg agcgacatcc agagcggcca gcagtccggt
     1501 cagcaccacc aatccggtcg gcagggcgac cggaccggcc acggacagca cggccaacag
     1561 accggccgcg aggagggcca gaaccagtac ggcggaagct ccgagagcgg attcagtccc
     1621 gtccagcaga ccatgatgcg cggcgaggag caacacgacc agcagagcga gtcgcggcga
     1681 tagccctcgt ccgccagtcg ccaacgcccg aacgactcgt gcaatcgtcc gaagacgcct
     1741 tttttcgctc gacgcgccga ctgtgacaga cgttagcact attgacgcgc ggcaccgact
     1801 ttcggccggg aatgggactg ttcaggacac cgattcgggc cgagcggcgg gccgaccgcg
     1861 aagcgggtgg gacgcgatga gcgacgcccc cgagaccgac cccgaggtcg gcgcgccagc
     1921 gcgacccggc gtcgattacg accgtctcga agacctcctc ggcgaccgcg tactcggacg
     1981 cgagagccac ctgaacgccg aggggttcgt cgtgcgcccg gacgccgccg agtcggtcct
     2041 ccggacgctc aaggacgagg cggggttcga ccacctctcg ctgttgaccg cccaagagta
     2101 cgaggaccgc tacgagagca tctaccacct caagaagtac gacgacccga cccacgaggt
     2161 cagcgtcgtc gtccccaccg accccgagga gccgtggaat cgaagcgcct cctcggtgta
     2221 caagaccgcc gagtggcacg agcgcgaagc ctacgacctc gtgggtatcg agtacgaggg
     2281 tcacccggac ctgcggcgca tcctcctgcc cgagacgtgg cagggccacc cactgaccga
     2341 cgactacgac cagaacaagc cgcaagtcgt cactcttcag aagcacgtca accccctcgc
     2401 cgaggacgcc cgcgacgagg agagcgagtc ggacacgatg ttcctcaaca tcggacccca
     2461 ccaccccgcg acccacggcg tcctccacct gaagacggtg ctggacggcg agcaggtcgc
     2521 cgacgtggaa cccgacgtgg gctacctcca ccggtgcgag gagcagatgt gcgagcagga
     2581 caactaccgc taccagataa tgccgtaccc cgaccgctgg gactacaccg cgaacatgcc
     2641 aaacgagtgg gcctacgccc gaaccgccga ggcgctcgcg gacatcgagg tgcccgagta
     2701 cgcccaagtc atccggacga tggcgaccga gttgggccgc atcatgggcc acatgctcgc
     2761 actgggcacg ttcgcgctcg acgtgtacgg cgacttcacg gccatcttca tgtacgcggt
     2821 cagggaccgc gaaatcgtcc agaacatcct cgaagacctc acgggccagc gcatgatgtt
     2881 caactacttc cggttgggcg gcgtggtctg ggacctgccg gaaccccgcg acgagttctt
     2941 cgacaagatt cgggacttcc tcgacggact gccccagcac gtcgaggagt accacgacat
     3001 gatgaccgag aacgagattt tccagaaacg gactgtcgat accggcgtca tctcggccga
     3061 gaccgcgaag gactacggct gtaccggccc ggtggcccgc ggttcgggcg tcgattacga
     3121 cctgcgccgc gacgacccct acggctacta cgacgaactc gactggaacg tcgtcacgga
     3181 accgtacggt gacaactact cgcgcgtgct ggtccggatg caggaggtcg aggagtccgc
     3241 gaagataatc ggccagtgcg tcgatatgct ggaggattgg ccggaagacg agcgcaacat
     3301 tcaggccaac gttccccgga cgctcaagcc cgaccccgac acggaggttt acagggccgt
     3361 cgaggccgcg aagggcgaga tgggcatcta catccggtcg gacgggacct cgaagccagc
     3421 ccggttcaag attcggagtc cgtgtttcaa caacctccac gcgctcgaag cgatggccga
     3481 gggcgagtac gtgcccgacc tcgtggccgc gctcgggagc ctcgacatcg tgttggggtc
     3541 tgtggacagg tagtgtcgct actgtccggt cgagtcgagt tcggtcgccc tgccgacggg
     3601 gttctcgacc gaatcggcgt ccgccccgtc gagtaggtcg tcgtcggctt cgaccacccc
     3661 gtcgagtcgt cgctcgaact cgtcttgtcc gatctccccg gcggcgtagc gtcgtttcag
     3721 cgtctcgacc ggacgctcct cgcgtgagtc gtccgtccga gtcgaactcg acgccgagga
     3781 gtcgccccga gtcagccccg agtcgggcgc gaacagcgtc gtcgtcgcga cgacgggcaa
     3841 aacgagagtc agcacgccga acaggagcgc gaggagattg tagacgacgc cgcttttcac
     3901 gccggagacg atggcgaacg tcgcgtacag cgagaggacg gccccgacgg ccgcgattcc
     3961 ggcgacgcgt cgtcgccacc gagaactgtc cggagtgtgt ctggccagcg gtcgcgggaa
     4021 actggaggag tcgccgggcg ggctcatgtc agatgggata tttcataccg aactgaaacg
     4081 cctttcggtg ggtcgggaac gattcggatc cggtggccac aaccgccttg cccgaccctc
     4141 ccgtggcaac tccatggtcg aactcggcta cacgctctcc agcgaggaac acggcccgac
     4201 tgacctcgtg agtcacgcgg tcagcgcgga agaacacggc ttcgacttcg cctccatctc
     4261 ggaccacttc cacccgtgga taggccagca gggccacgcg ccgttcgcgt gggccacgct
     4321 cggcggggtc gccgcggcga ccgacgactt ggacgtgggc gtcggcgtga cctgtcccac
     4381 ggtccgaatc caccccgcga ttctcgcgca ggccaccgcg acgatagcga cgatgttcga
     4441 ggagtccggc cagcagttct acttcggcgt cgggaccggc gagaacctga acgaacacgt
     4501 cctcggcgac cactggccgc cccacgacgt tcgcctcgac atgctcgaag aagccgtcga
     4561 ggtgattcgg aagctctgga ccggcgagat ggtcagccac cacggcgacc actacaccgt
     4621 cgagaacgcg aagctgttca ccctgcccga cgagaatccg cccgtctgcg tgtcggcgta
     4681 cggcgaccgg accgcgagcc acgccgcaga tttgggcgac ggcttctggt cggtcggccc
     4741 gcaggacgtg gtcgagacct tcgaggagga cggcggcgag ggaccgaagt tcagtcagct
     4801 cacggtctgc tacgcagacg acgaggacga ggcggtcgag accgcccacg agtactggcc
     4861 caacagcctc ctgccggggc aactcgccac cgaactcgcc acgccgcagt tcttcgagca
     4921 ggcctgccag atggtcgaga aggaggacgt gcgcgaggcc gacagcatcg tgaccgaccc
     4981 cgacccgcag gcccacgtcg agagcgtccg ggagttcgtg gacgcgggct acgaccacgt
     5041 gtacgtccac caaatcggcc cggagcagga ggaggccatg gagttctacg agcagaacgt
     5101 cctgccggag ttccgatagg acggccccga accgcggccg tcgctcggcg actgcgaccc
     5161 gttgctcggc gactgtgaag tcactcgggg gcgacaacct cgactttgac tccctccggg
     5221 ccctcgcagt agagcgcgta gtagccgcca gcgaagggat gttgctcctc gaagaggaga
     5281 cccgcgtcgt cgcgctcgcg gacgccctcc gtaatcgcat cgacctgctc gcgggacgcg
     5341 gcgtgaaagg cgaggtggtt gagtccggcg gcgtcacggt cgaaggggtg gtcggactcg
     5401 tcggcccgca cgaggacgac gtacgtcggg tcgcgaatcc acgagcgacc ggcctcccag
     5461 tcgttcttcg gttcgtatcc caactccccg agcaaccagt cccagaacgg gaccgacgca
     5521 tcgaggtccg aggcgtacag ttcgacgtga tggagttgcc ccgcccgctc ggggtcggcg
     5581 tggtcacggc tcacgagagc cgattcacgg acgacttaca aatgcgttcg gccagcggcc
     5641 gaacgccgaa gagaggggga gcctcaaatc ggacagccgc gaatctcgcc gccgcgcatc
     5701 ccgtcggcga cccagtagat ggacagcacg agcgcgacca gcgcgaggac cgagaactcc
     5761 agtccgtcga aggggagcag ggtcgccgcg cccgcgacgc cgaacaacga gaggagtccc
     5821 gccagcacgg ccgacccgca ggcggcacag ccagcgccga gcgcgccgag gacgagaccg
     5881 accgtgcttc cgcccgcggc cccgccgcca gcgcgctctc gctcgctcgg tccgaccccg
     5941 tgttcccgga agtggtagac gaccatcgcc acgtccacgc ccgcgagcgc ggcgatggcg
     6001 acgagcagga cctccgcgac cggcccgtag ttcgtgccga ggagggggta gagaccgaac
     6061 aggatggtcg cgcggtcgcc gagtccgata ggagcggtca gcgcgaactc cgccagcgcg
     6121 aggttctgcc cgagaacgaa cgccgagagc gccagcaggg cggtgacgac ggtgagcgcg
     6181 gcgtagaccg ggccagccaa cacgagacgc gcggtccgac ccatgagtcg ccagtcgtcg
     6241 gggcgagtcg gcaggcgcgg acggagccgc cggagtccgg cgagactcac ggtcacaccc
     6301 cgagcgcggc tttcacgacc tgaaagctga tgctcccctt cgcgctggtc cggaactcgt
     6361 cgccgcggaa caggaatacg gtcggggtcg tctggccgac gcccgccttc ttcccggcgt
     6421 cgaggtcggc ctgcaccgcg tcgtcgtgga cgttctcctc ggcgtcggcg acgacggcct
     6481 ccgcgtcgag gtcggtctcg tcggcgagga aggttctggt tcgctcgaag acgttgttcg
     6541 tgtcgaactg ctcttgggtc tcgaagtagt ggccgacgag cgcccacgtc gcttccgacc
     6601 cctgtcggaa ccccggtcgc gcggcggtcg aggcgtcggc gggcgggtcg cggtcggagt
     6661 ccgaattcgc catctcgtgg gcgaacgccg actcgatggc ctgcgtcgcg ggttcgcccc
     6721 acgggtagac cacggggtag ctccggagga cgaacgacac gcggtcgccg agtcgctcgc
     6781 gtatcttcgg caccgtgttg cgctcgaagg ccgcgcatcg cgtacaggag gggtcctcga
     6841 aggcgacgac ggttccctcg gcctcggacg gcggcgggcc gaaccgcggt tgggcggcga
     6901 gacccgccgc ggccgagtga cccccgagcg gcgcggtcgc cgttccggtc gctcctgtcg
     6961 tcgattcggt cgtcccgccg gtcgtctcgg gcgacgcgcc ggactcctcg ctttcggagc
     7021 gaccgccgat acaacccgcg agcgaaccca gcgcggtcgc tccgccgacg ccgaggagtc
     7081 ggcggcgagt ccacgaccga gacgctgtgt ctgtcatacg tacatcggag acgccgaccg
     7141 gtatatgcgt tgttccaatt tcgtgccgag accgggccga ttctccgcgc tcgtgcccgc
     7201 gaaggtcaaa cgcgcgtttc actcatccgc aggtttacgg tggtagaata tgacaaccga
     7261 cctatggcac gcgacagtgt actcggaggc ggcggcgcgc gacggtgggc gctcgcgctg
     7321 gtactcgctt cgctggttct cctcgcgggg tgttccggca gcgggggcga cgccgcgatg
     7381 caagcgacct cggggcagaa tctcgacgta tcgaccgacg cggaagcgac tcagcgcgcg
     7441 agcgacggcg gcggcacgaa ctcccagagc gacgcggcgg cccggaaccg ggcgctgatt
     7501 cggaccggga cggtcgaggt gacggtcgaa gactacgacg acgctcgtcg gaacctcacg
     7561 cgccagaccg aacgactcgg cgggttcgtc agcgactcgg cccagcaggt cgagacgcgc
     7621 gggaaccgga cgtggacgaa cgggaaactc gtcctgcgag ttccgaaaaa gaacttctcg
     7681 gcgctcgtcg cgcgggccaa ggcgaccggc gaggtccgcg cggccagcac cagcacgaag
     7741 gacgtgacga agaaactcgt ggacatcgag gcgcgactga cgaatctgaa ggcccagcgc
     7801 gaggagttgc gcgacctcta cgccgaggcc aacgacaccg agaacgttct ggaagtccaa
     7861 gaacgcctct cggaggtcca gtccgaaatc gaacagttgg aggcccagcg caagtcgttg
     7921 aaccgacagg tcgcctactc gacgctgacg gtccgcctcc acgagcgtcc gcccgagcag
     7981 accgcccaac agagcgccgc gtggtacgac actggcctcg tcgccgcgtt cgtctcgtcg
     8041 gccagcggcg tcgtggtcgt cgcgcgcgga ctggcggtcg gcacggcgta cgcgctcccg
     8101 tacctcgtcg cgttcggcct cccggtcgtc ggggtggtcg cgctctggcg acggcgctcg
     8161 gcggactcct cgggcgcgga cctccccgac gctcccgaat cgccggaggg cggagagtct
     8221 ggcgaagacg acgattgacg ggattttcgg gggctgtgct tctcggtcgc gcacgttcgt
     8281 ttctcccggt cggtcaatcc cggcagtttt tattaccggg aagcgtaaag cccgcataga
     8341 ccgatagctc ggaggacgtg gcactgccac cgcgcggtcc caccgatggc tgtaagacgc
     8401 cacggcgggg accgcgtcgc tccgagcagg tttacgtgcg tacggacgcc atcggcgtgg
     8461 ccttgccgtg tagtgtggcg ctgtcacgta gcgtgggttt cccacgtagc gtgggtctcc
     8521 cacgtagcgt gggtctccca cgtagcgtgg ccttgccacg gaagaaacga cgcggctccg
     8581 ccgcaggaac gcagacggac gcggcttcgt cacgaacggt ggctttgcgt acactagggt
     8641 gaaactatgg aaatcgaaat tgcaaccatc ggcggttacg aagaagtcgg acggcagtgt
     8701 actgccgttc gcgcaggcga cgacgttgtc atcttcgaca tggggctgaa cctctcgaag
     8761 gtactgctcc acgacaacgt cgagacagag aaactacaca gtctggacct catcgacatg
     8821 ggggccatcc cggacgaccg cgtgatgtcg gacctcgaag gcgacgtgca ggccatcgtc
     8881 ccgactcacg gccacttgga ccacatcggg gccatctcga agctggccca ccggtacaac
     8941 gcaccggtcg tcgcgacgcc gtacaccatc gaactcgtca aacagcagat tcagggcgag
     9001 gagaagttcg gcgtcgagaa cgacctcgtg aagatggaag ctggctcgac gatgtccatc
     9061 ggcgactccg ggaaggtcga gttggagttc gtcaacgtga cccactccat catcgacgcc
     9121 atcaaccccg tcctccacac gccggagggc gcggtcgtct acggtctcga caagcgcatg
     9181 gaccacacgc cggtgctggg cgaccccatc gacatgaagc ggttccgcga aatcggccgc
     9241 gagggcgagg gcgtgctggc ctacatcgag gactgtacca acgcgggccg gaagggccgc
     9301 accccgagcg agtcggtcgc tcgccgccac ctcaaggacg tgatgacctc cgtcgaggac
     9361 tacgacggcg gcatcgtggc gacgacgttc tccagccaca tcgcccgcgt caagagtctc
     9421 gtggagtacg cccacgacat cggccgcgag ccggtactcc tcgggcgctc gatggagaag
     9481 tactcgggca ccgcggaacg actcgacttc gttgacttcc ccgaagacat ggggatgttc
     9541 ggccaccgca agtccgtgga ccgaacgttc aagcgaatca tgaaggaggg caaggagaac
     9601 tacctcccca tcgtcacggg ccatcagggc gagccgcgcg cgatgctcac ccggatgggc
     9661 cgcggcgaga caccgtacga actggaagac ggcgacaagg tcatcttctc ggcccgcgtc
     9721 attccggaac cgaccaacga ggggcagcgc taccagtccg agcgcctcct gaagatgcag
     9781 ggcgcgcgca tctacgacga catccacgtg tcgggtcacc tccgcgagga gggccactac
     9841 gcgatgatag acgcgctcca gccccagaac atcatcccgg cccaccaaga catgaaaggg
     9901 ttcgcgccgt acgtgagcct ctgtgagagt cagggctacg aactcggccg ggacctccac
     9961 gtaacgagca acggcaacct catccaactc gccgagtaac atgacagacg cgagcgccga
    10021 gacactggaa gagcaggtgc ttggggcggt cgaacagcgg cgggaaatcg tcaacgccgc
    10081 catcgaggag gacctgcccg tggacgagcc cgaacggctc tacgaggcgg tccgctacct
    10141 gctcgacgcg ggcggcaagc gcctccggcc gaccgtgctg ttgctcgtcg ccgaggcgtt
    10201 cgcggacgta gacgccaccc ccgagagcat cgactatcgg gacttccccg acagggacgg
    10261 tgacagcgtg gacgtgatgt ccgccgcggt cgcaatcgag gtcatccagt cgttcacgct
    10321 catccacgac gacatcatgg acgacgacga cctgcgccgg ggcgtccccg cggtccaccg
    10381 ggagtacgac accgagaccg cgattctcgc gggcgacacg ctctactcga aggcgttcga
    10441 gatactcgtg gaagccgacg ccgaccccga gcgcgtcgtg gaagcgaccg acgtgttggc
    10501 gacgacgtgt accaacatct gcgagggcca agctcgcgac atcgcgttcg aagagcgccc
    10561 gaacgtcgtc cccgacgagt atctggagat gataaaggac aagaccgcgg tgctgtacgg
    10621 cgcggcggcg accatcccgg ccatcctgct cggcgcggac gacgagaccg tcgaggagtt
    10681 gtaccagtac ggtatcgacg ttggccgggg attccagatt caggacgacg tgctggacct
    10741 gacggtcccg agcgagaagt tgggcaaaca gcgcgggagc gacctcgtgg agaacaaaca
    10801 gaccatcatc acgcttcacg cccgcgagca gggcgttgac gtggattcgc tggtcgagac
    10861 cgacgacgtg gagtcggtca cggaggccga aatcgacgag gcggtcgccc gccttgagga
    10921 ggccggaagc atcgactacg ccaaggagac ggcccaagag ttggtcacgc gcggcaaaga
    10981 ccgactcacc gtcctcccgg aaaacgagtc gcgcgacctg ctggaaggca tcgccgacta
    11041 cctcatcgag cgcggctact gacccgctcg tcgggaccgt tctcctcggc gtgcttttct
    11101 cgtcgcgcgc ttctcctcgc ggtctggttc tgtactcggc gaaatgatac gaaacgagag
    11161 cgacgatacg gagcgagcga cgtgaagaac ggagggcgcg tcagcgggga ctgacggtgg
    11221 tcggcggggc ggtgcttctc ggccgcgggc gctactcgat acgagtccga agaagggcgc
    11281 cagcgcgacc ggccgcggtc attcgttcgg gaactctttg tagtgggtgt gttcgagata
    11341 ctcttcgagc gtgggctgtc gccagtaacg tacgacatcg ctgcgctcgt cgtactccac
    11401 gatgtcggcc tcgccgagac gggggaggtg ggtctcccga agctcctcgg cgatagcctc
    11461 gtggcgggcg tccgtgatcg gctcgtcgcc ggtccgggcc tcccacatgg ccacttcgtc
    11521 ggccagttgc tcgacctcgg cgagaccgtc ctcggttccg ataagcgtgt agagtgcgta
    11581 ccggcgtcgg ctctccgcga ggaggtcgaa gagctcgtcg aacgagggcg tcgtgactgc
    11641 gcgaccgttc tggagggcgt ggtcgccctc ggtacccgag cgaatggtcg tgttaagttt
    11701 ggcatgaatt gtgccagacg gcgaaggctt gcaaccacga ttctgctgtt tctagctcgg
    11761 cgttgcggaa cgcgttcgaa aacgaagaag ttcgtcgttt tacctcgcgg aa
//
