GCF_004365115.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_SOCO01000001.1 (Stenotrophomonas sp. CC22-02)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	958,060	968,935
Region 1.2	lanthipeptide-class-ii	1,175,373	1,198,273
Region 1.3	lassopeptide	1,724,308	1,746,863
Region 1.4	NRP-metallophore,NRPS	2,027,200	2,075,567	High	2,3-dihydroxybenzoylserine	NRPS:Type I
Region 1.5	terpene-precursor	2,665,152	2,686,030

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	958,060	968,935
Region 1.2	lanthipeptide-class-ii	1,175,373	1,198,273
Region 1.3	lassopeptide	1,724,308	1,746,863
Region 1.4	NRP-metallophore,NRPS	2,027,200	2,075,567	High	2,3-dihydroxybenzoylserine	NRPS:Type I
Region 1.5	terpene-precursor	2,665,152	2,686,030

No secondary metabolite regions were found in these records:: NZ_SOCO01000002.1 (Stenotrophomonas sp. CC22-02); NZ_SOCO01000003.1 (Stenotrophomonas sp. CC22-02); NZ_SOCO01000004.1 (Stenotrophomonas sp. CC22-02); NZ_SOCO01000005.1 (Stenotrophomonas sp. CC22-02); NZ_SOCO01000006.1 (Stenotrophomonas sp. CC22-02); NZ_SOCO01000007.1 (Stenotrophomonas sp. CC22-02)

Compact view

NZ_SOCO01000001.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 958,060 - 968,935 nt. (total: 10,876 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.27	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001650.4	0.23	NRPS	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0000452.5	0.21	NRPS	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0000651.5	0.20	terpene	KS-505a	Streptomyces argenteolus
BGC0001283.3	0.18	PKS	Bisenarsan	Streptomyces lividans 1326

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.27	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001650.4	0.23	NRPS	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0000452.5	0.21	NRPS	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0000651.5	0.20	terpene	KS-505a	Streptomyces argenteolus
BGC0001283.3	0.18	PKS	Bisenarsan	Streptomyces lividans 1326

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.64 out of 26.85

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 20.47

Confidence: medium

Additional weak hits (2):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.71 out of 39.62

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_SOCO01000001.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,175,373 - 1,198,273 nt. (total: 22,901 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

N440_RS05695: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.52	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.46	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001576.3	0.43	ribosomal	divamide A	Prochloron didemni
BGC0000500.5	0.41	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002316.2	0.41	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0002704.2	0.41	ribosomal	archalan β	Halorussus salinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.52	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.46	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001576.3	0.43	ribosomal	divamide A	Prochloron didemni
BGC0000500.5	0.41	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002316.2	0.41	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0002704.2	0.41	ribosomal	archalan β	Halorussus salinus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for N440_RS05695

N440_RS05690

Leader:

MDLNDDVVSGWLNGSDDVDGCANPAGSLFIYGA

Core:

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

Core with dehydrations:

AADhbEDhaALDhbDhaADhaDDhbLIDhbGGGDhbECysDhbDhbDhbMDhaVVNHCysLCysCys

antiSMASH-DB 4.0 matches for N440_RS05690

100.0%

NZ_CP015612.1and 17 others:

NZ_CP027562.1 Lanthipeptides: C6Y55_RS08375_lanthipeptideNZ_CP028358.1 Lanthipeptides: C9J74_RS08630_lanthipeptideNZ_CP040435.1 Lanthipeptides: FEO92_RS08800_lanthipeptideNZ_CP040438.1 Lanthipeptides: FEO89_RS08350_lanthipeptideNZ_CP040439.1 Lanthipeptides: FEO88_RS08780_lanthipeptideNZ_CP056088.1 Lanthipeptides: HUZ96_RS08220_lanthipeptideNZ_CP090418.1 Lanthipeptides: LYZ64_RS08310_lanthipeptideNZ_CP109812.1 Lanthipeptides: FQS62_RS08595_lanthipeptideNZ_DS999412.1 Lanthipeptides: SSKA14_RS15505_lanthipeptideNZ_JAEDUZ010000008.1 Lanthipeptides: JAK52_RS03215_lanthipeptideNZ_JAEDWK010000010.1 Lanthipeptides: JAK51_RS04155_lanthipeptideNZ_JAJNMF010000022.1 Lanthipeptides: LQ423_RS11465_lanthipeptideNZ_JVUI01000059.1 Lanthipeptides: ADG58_RS15825_lanthipeptideNZ_LR134301.1 Lanthipeptides: EL200_RS07985_lanthipeptideNZ_OBEE01000002.1 Lanthipeptides: CRO53_RS02030_lanthipeptideNZ_RHQE01000015.1 Lanthipeptides: EGJ89_RS13150_lanthipeptideNZ_SOCO01000001.1 Lanthipeptides: N440_RS05690_lanthipeptide

Lanthipeptides: A7326_RS08120_lanthipeptide

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

97.1%

NZ_CP011010.1:

Lanthipeptides: VN11_RS08230_lanthipeptide

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

AATESALT+ASDTLITGGGTECTTTMSVVNHCLCC

AATESALTAASDTLITGGGTECTTTMSVVNHCLCC

97.1%

NZ_CP043578.1and 3 others:

NZ_CP067993.1 Lanthipeptides: JJL50_RS07700_lanthipeptideNZ_JVHP01000063.1 Lanthipeptides: ADI44_RS21105_lanthipeptideNZ_OU943334.1 Lanthipeptides: LNN95_RS09005_lanthipeptide

Lanthipeptides: F0Q13_RS08255_lanthipeptide

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

GATESALTSASDTLITGGGTECTTTMSVVNHCLCC

with 16 more sequence matches

Only the first 10 are displayed here.

72.3%

NZ_CP047310.1and 4 others:

NZ_CP104169.1 Lanthipeptides: NDR96_RS06465_lanthipeptideNZ_JABDRV010000001.1 Lanthipeptides: HRL60_RS01085_lanthipeptideNZ_JAEDVS010000025.1 Lanthipeptides: JAK50_RS15965_lanthipeptideNZ_JVPM01000038.1 Lanthipeptides: ADH50_RS19075_lanthipeptide

Lanthipeptides: GS396_RS07720_lanthipeptide

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

37.1%

NZ_CP011305.1and 19 others:

NZ_CP031058.1 Lanthipeptides: DUW70_RS15590_lanthipeptideNZ_CP031167.1 Lanthipeptides: MG068_RS07815_lanthipeptideNZ_CP040436.1 Lanthipeptides: FEO91_RS08085_lanthipeptideNZ_CP046588.1 Lanthipeptides: GOC52_RS08100_lanthipeptideNZ_CP060259.1 Lanthipeptides: H7F32_RS08235_lanthipeptideNZ_CP071784.1 Lanthipeptides: J3U96_RS13765_lanthipeptideNZ_CP077679.1 Lanthipeptides: KS456_RS07940_lanthipeptideNZ_CP096975.1 Lanthipeptides: M1L61_RS08375_lanthipeptideNZ_CP104071.1 Lanthipeptides: K7565_RS07800_lanthipeptideNZ_CP104287.1 Lanthipeptides: K7567_RS07875_lanthipeptideNZ_CP104324.1 Lanthipeptides: K7569_RS08320_lanthipeptideNZ_JACLBK010000002.1 Lanthipeptides: ID844_RS05155_lanthipeptideNZ_JAEDVP010000027.1 Lanthipeptides: JAK38_RS15550_lanthipeptideNZ_JAEDVW010000007.1 Lanthipeptides: JAK53_RS03160_lanthipeptideNZ_JAEDWD010000009.1 Lanthipeptides: JAK45_RS02000_lanthipeptideNZ_JAFLWT010000006.1 Lanthipeptides: J1F00_RS06425_lanthipeptideNZ_JAQQGI010000014.1 Lanthipeptides: PQS91_RS16925_lanthipeptideNZ_KB907502.1 Lanthipeptides: G370_RS0114170_lanthipeptideNZ_RHPZ01000014.1 Lanthipeptides: EGJ03_RS16365_lanthipeptide

Lanthipeptides: YH67_RS07965_lanthipeptide

ECTTTMSVVNHCLCC

ECTTT+SV+NHCLCC

ECTTTVSVINHCLCC

36.2%

NZ_CP007597.1:

Lanthipeptides: DX03_RS09815_lanthipeptide

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

AT++ALT+ + T++TGG CTTTMSV+NHC+CC

ATDAALTAMAPTMVTGGTGNCTTTMSVINHCMCC

29.3%

NZ_CP069396.1:

Lanthipeptides: JRI60_RS03735_lanthipeptide

AATESALTSASDTLIT

AATE+ALT ASD L+T

AATENALTDASDALVT

28.8%

NZ_CP069338.1:

Lanthipeptides: JQX13_RS07220_lanthipeptide

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

ATE+ALT+++D L T G + CT ++ H CC

ATEAALTNSTDALYT-GCSSCTGSL----HSYCC

26.4%

NZ_CP093340.1:

Lanthipeptides: MNO14_RS04685_lanthipeptide

AATESALTSASDTLITGGGTECTT-TMSVVNHC

AATE+A+T S L+ T+C++ T S+ HC

AATEAAMTDKSFLLL----TQCSSCTASIPAHC

24.4%

NZ_CP029194.1and 1 other:

NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide

Lanthipeptides: DEJ46_RS04155_lanthipeptide

AATESALTSASDTLITG

AA E+ALT A++ L+TG

AAGEAALTDATEALLTG

24.4%

NZ_JH941044.1:

Lanthipeptides: Y19_RS0126875_lanthipeptide

AATESALTSASDTLITG

AA E+ALT A++ L TG

AAGEAALTDATEALFTG

22.9%

NZ_CP089924.1:

Lanthipeptides: LVB77_RS02735_lanthipeptide

TGGGTECTTTMSVVNHC

+G CT+ SV NHC

SGASVNCTSGSSVSNHC

22.0%

NZ_CP010407.1and 4 others:

NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide

Lanthipeptides: SVTN_RS37515_lanthipeptide

AATESALTSASDTLITG

AA E+ALT ++ L+TG

AAGEAALTDGTEALLTG

allorf_1178234_1178455

Leader:

MAPSMAPTVLERAACPLLTVSWCVRTRRSAGRLLPGFAGNRPEAVGSPRA

Core:

GPLAPWMAPSSPHGWVHGVSCPG

Core with dehydrations:

GPLAPWMAPDhaDhaPHGWVHGVDhaCysPG

antiSMASH-DB 4.0 matches for allorf_1178234_1178455

88.5%

NZ_RHPZ01000014.1and 1 other:

NZ_SOCO01000001.1 Lanthipeptides: allorf_1178234_1178455_lanthipeptide

Lanthipeptides: allorf_009576_009797_lanthipeptide

GPLAPWMAPSSPHGWVHGVSCPG

84.6%

NZ_CP046588.1and 6 others:

NZ_CP056088.1 Lanthipeptides: allorf_1820746_1820967_lanthipeptideNZ_CP060259.1 Lanthipeptides: allorf_1747353_1747574_lanthipeptideNZ_CP104071.1 Lanthipeptides: allorf_1665125_1665346_lanthipeptideNZ_CP109812.1 Lanthipeptides: allorf_1794166_1794387_lanthipeptideNZ_JVPM01000038.1 Lanthipeptides: allorf_457583_457804_lanthipeptideNZ_OU943334.1 Lanthipeptides: allorf_1870884_1871105_lanthipeptide

Lanthipeptides: allorf_1742372_1742593_lanthipeptide

GPLAPWMAPSSPHGWVHGVSCPG

GPLAP MAPSSPHGWVHGVSCPG

GPLAPRMAPSSPHGWVHGVSCPG

80.8%

NZ_CP040435.1:

Lanthipeptides: allorf_1850191_1850412_lanthipeptide

GPLAPWMAPSSPHGWVHGVSCPG

GPLAP MA SSPHGWVHGVSCPG

GPLAPRMASSSPHGWVHGVSCPG

with 7 more sequence matches

43.5%

NZ_CP101417.1:

Lanthipeptides: allorf_0369305_0369400_lanthipeptide

WMAPSSPHGWVHGVSC

WM P S HG GVSC

WMPPPSLHGRTCGVSC

30.8%

NZ_JABDRV010000001.1:

Lanthipeptides: allorf_0223350_0223580_lanthipeptide

APSSPHGWVHGVSCPG

22.5%

NZ_PUPX01000001.1:

Lanthipeptides: allorf_1103640_1103849_lanthipeptide

WMAPSSPHGWVHGVS

WM S HG +HGVS

WMPLRSLHGRIHGVS

21.1%

NZ_JAEDVW010000007.1:

Lanthipeptides: allorf_22564_22716_lanthipeptide

MAPSSPHGWV

APSSPHG V

KAPSSPHGEV

18.8%

NZ_MJGO01000037.1:

Lanthipeptides: BIU97_RS08315_lanthipeptide

LAPWMAPSSPHG

L+ +M P+SP+G

LSIYMCPTSPNG

15.6%

NZ_CP023445.1:

Lanthipeptides: allorf_6233670_6233849_lanthipeptide

GPLAPWMAPSSP

GP A W P SP

GPAAGWRTPDSP

8.5%

NZ_CP035119.1:

Lanthipeptides: allorf_0912767_0912979_lanthipeptide

PLAPWMAPSSPHGW

P+A + +P+ PH +

PVASFYSPNRPHRF

allorf_1178421_1178636

Leader:

MDGFTACPALGDPTGSSRLQGS

Core:

ANATNPTATIGNPGKQKSPREAGFFGSCCGDWRSLGDSNPCFSLERATS

Core with dehydrations:

ANADhbNPDhbADhbIGNPGKQKDhaPREAGFFGDhaCysCysGDWRDhaLGDDhaNPCysFDhaLERADhbDha

antiSMASH-DB 4.0 matches for allorf_1178421_1178636

100.0%

NZ_SOCO01000001.1:

Lanthipeptides: allorf_1178421_1178636_lanthipeptide

ANATNPTATIGNPGKQKSPREAGFFGSCCGDWRSLGDSNPCFSLERATS

28.6%

NC_018485.1:

Lanthipeptides: allorf_3283390_3283524_lanthipeptide

WRSLGDSNPCFSLERATS

WR+ GDSNPCF ERATS

WRAQGDSNPCFRRERATS

24.5%

NZ_CP029354.1:

Lanthipeptides: allorf_108572_108748_lanthipeptide

ATNPTATIGNPGKQKSPREAGFFGSCCGDWRS

A NP TIG RE F C +W S

APNPIKTIG--------REMTHFLCQCNEWFS

with 2 more sequence matches

18.4%

NZ_CP046956.1:

Lanthipeptides: allorf_0712042_0712206_lanthipeptide

KQKSPREAGFFGSCCGDW

KQK+ G F SCC W

KQKTL-SCGIFSSCCSRW

16.3%

NZ_CP084541.1:

Lanthipeptides: LC193_RS09325_lanthipeptide

GSCCGDWRSLGDSNPCF

GSCCG W + + CF

GSCCGAWLPVPTAFTCF

allorf_1184819_1184995

Leader:

MPATGRPSLHLTSRPCTRPSVLRVPCIRVPAAAQLDAALNADAVCTGG

Core:

STCHPVSLAA

Core with dehydrations:

DhaDhbCysHPVDhaLAA

antiSMASH-DB 4.0 matches for allorf_1184819_1184995

100.0%

NZ_CP011010.1and 3 others:

NZ_DS999412.1 Lanthipeptides: allorf_3459447_3459623_lanthipeptideNZ_JAJNMF010000022.1 Lanthipeptides: allorf_02257_02373_lanthipeptideNZ_SOCO01000001.1 Lanthipeptides: allorf_1184819_1184995_lanthipeptide

Lanthipeptides: allorf_1772540_1772716_lanthipeptide

STCHPVSLAA

45.0%

NZ_CP040436.1and 11 others:

NZ_CP040438.1 Lanthipeptides: allorf_1797077_1797235_lanthipeptideNZ_CP040439.1 Lanthipeptides: allorf_1871764_1871973_lanthipeptideNZ_CP071784.1 Lanthipeptides: allorf_3040363_3040476_lanthipeptideNZ_CP104071.1 Lanthipeptides: allorf_1671217_1671393_lanthipeptideNZ_CP104287.1 Lanthipeptides: allorf_1684276_1684389_lanthipeptideNZ_CP104324.1 Lanthipeptides: allorf_1768103_1768216_lanthipeptideNZ_JACLBK010000002.1 Lanthipeptides: allorf_262851_262964_lanthipeptideNZ_JAEDWD010000009.1 Lanthipeptides: allorf_029791_029967_lanthipeptideNZ_JAFLWT010000006.1 Lanthipeptides: allorf_148855_148968_lanthipeptideNZ_JVUI01000059.1 Lanthipeptides: allorf_017163_017279_lanthipeptideNZ_KB907502.1 Lanthipeptides: allorf_016175_016288_lanthipeptide

Lanthipeptides: allorf_1728172_1728348_lanthipeptide

TCHPVSLAA

23.1%

NZ_AUFR01000008.1and 1 other:

NZ_CP033719.1 Lanthipeptides: allorf_1493428_1493565_lanthipeptide

Lanthipeptides: allorf_101055_101192_lanthipeptide

TCHPVSLAA

TC+PVS A+

TCNPVSFAS

with 1 more sequence matches

12.2%

NZ_JACHJQ010000008.1:

Lanthipeptides: allorf_200802_200999_lanthipeptide

STCHPVSL

S CHPV L

SACHPVDL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.95 out of 32.74

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19

Confidence: medium

Additional weak hits (7):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.42 out of 25.88

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.46 out of 32.74

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.79 out of 29.65

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.90 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.61 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.18 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.00 out of 24.78

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

N440_RS05690 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3231.5 Da

Molecular weight: 3233.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3251.6 Da N = 1; 3269.6 Da N = 2; 3287.7 Da N = 3; 3305.7 Da N = 4; 3323.7 Da N = 5; 3341.7 Da N = 6; 3359.7 Da N = 7; 3377.8 Da N = 8

allorf_1178234_1178455 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 2272.1 Da

Molecular weight: 2273.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2291.6 Da N = 1; 2309.6 Da N = 2

allorf_1178421_1178636 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 4922.3 Da

Molecular weight: 4925.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4943.3 Da N = 1; 4961.4 Da N = 2; 4979.4 Da N = 3; 4997.4 Da N = 4; 5015.4 Da N = 5; 5033.4 Da N = 6; 5051.5 Da N = 7

allorf_1184819_1184995 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 930.5 Da

Molecular weight: 931.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 949.1 Da N = 1; 967.1 Da N = 2

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
FuR variant 2	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_SOCO01000001.1 - Region 3 - lassopeptide

Download region GenBank file

Download region SVG

Location: 1,724,308 - 1,746,863 nt. (total: 22,556 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

N440_RS08105: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000576.3	0.52	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000573.3	0.49	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0000577.3	0.48	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0001786.3	0.46	ribosomal	subterisin	Novosphingobium subterraneum
BGC0001779.5	0.44	ribosomal	siamycin	Streptomyces nodosus
BGC0001645.3	0.44	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0002064.2	0.42	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002015.4	0.41	ribosomal	aborycin	Streptomyces sp. ZS0098

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000576.3	0.52	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000573.3	0.49	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0000577.3	0.48	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0001786.3	0.46	ribosomal	subterisin	Novosphingobium subterraneum
BGC0001779.5	0.44	ribosomal	siamycin	Streptomyces nodosus
BGC0001645.3	0.44	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0002064.2	0.42	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002015.4	0.41	ribosomal	aborycin	Streptomyces sp. ZS0098

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for N440_RS20340

N440_RS20340

Leader:

MNELIELGVVAGEQNHEDQGELIELGSVVSETK

Full core:

AHNHGTLWDGVFPTTSP

Putative macrolactam:

AHNHGTLWD

antiSMASH-DB 4.0 matches for N440_RS20340

100.0%

NC_011071.1and 41 others:

NZ_AP021867.1 Lassopeptides: GJU96_RS20605_lassopeptideNZ_CP011010.1 Lassopeptides: VN11_RS22530_lassopeptideNZ_CP011305.1 Lassopeptides: YH67_RS21020_lassopeptideNZ_CP015612.1 Lassopeptides: A7326_RS21600_lassopeptideNZ_CP027562.1 Lassopeptides: C6Y55_RS23185_lassopeptideNZ_CP029773.1 Lassopeptides: DM611_RS22725_lassopeptideNZ_CP031058.1 Lassopeptides: DUW70_RS11975_lassopeptideNZ_CP031167.1 Lassopeptides: MG068_RS21080_lassopeptideNZ_CP037858.1 Lassopeptides: EZ304_RS20935_lassopeptideNZ_CP040432.1 Lassopeptides: FEO95_RS22840_lassopeptideNZ_CP040438.1 Lassopeptides: FEO89_RS21625_lassopeptideNZ_CP040439.1 Lassopeptides: FEO88_RS23220_lassopeptideNZ_CP043578.1 Lassopeptides: F0Q13_RS11365_lassopeptideNZ_CP046588.1 Lassopeptides: GOC52_RS10870_lassopeptideNZ_CP047310.1 Lassopeptides: GS396_RS20180_lassopeptideNZ_CP060259.1 Lassopeptides: H7F32_RS11180_lassopeptideNZ_CP067993.1 Lassopeptides: JJL50_RS10815_lassopeptideNZ_CP077679.1 Lassopeptides: KS456_RS10490_lassopeptideNZ_CP080573.1 Lassopeptides: K1516_RS11235_lassopeptideNZ_CP090418.1 Lassopeptides: LYZ64_RS11980_lassopeptideNZ_CP096975.1 Lassopeptides: M1L61_RS12085_lassopeptideNZ_CP104169.1 Lassopeptides: NDR96_RS09175_lassopeptideNZ_CP106759.1 Lassopeptides: N8888_RS09665_lassopeptideNZ_CP120400.1 Lassopeptides: PVE91_RS09960_lassopeptideNZ_JABDRV010000002.1 Lassopeptides: HRL60_RS08285_lassopeptideNZ_JADCQA010000003.1 Lassopeptides: IMX13_RS03920_lassopeptideNZ_JAEDVS010000016.1 Lassopeptides: JAK50_RS09365_lassopeptideNZ_JAEDVW010000040.1 Lassopeptides: JAK53_RS10000_lassopeptideNZ_JAEDWA010000005.1 Lassopeptides: JAK63_RS01795_lassopeptideNZ_JAEDWK010000019.1 Lassopeptides: JAK51_RS11395_lassopeptideNZ_JAEDWU010000002.1 Lassopeptides: JAK37_RS06750_lassopeptideNZ_JAKJQX010000001.1 Lassopeptides: MT466_RS00850_lassopeptideNZ_JAQQGI010000001.1 Lassopeptides: PQS91_RS01155_lassopeptideNZ_JVHP01000037.1 Lassopeptides: ADI44_RS25485_lassopeptideNZ_JVPM01000019.1 Lassopeptides: ADH50_RS20965_lassopeptideNZ_JVUI01000038.1 Lassopeptides: ADG58_RS23065_lassopeptideNZ_OBEE01000001.1 Lassopeptides: CRO53_RS21815_lassopeptideNZ_OU943334.1 Lassopeptides: LNN95_RS11880_lassopeptideNZ_RHPZ01000001.1 Lassopeptides: EGJ03_RS21120_lassopeptideNZ_RHQE01000001.1 Lassopeptides: EGJ89_RS22430_lassopeptideNZ_SOCO01000001.1 Lassopeptides: N440_RS20340_lassopeptide

Lassopeptides: SMAL_RS21110_lassopeptide

AHNHGTLWDGVFPTTSP

88.2%

NZ_CP058243.1:

Lassopeptides: AD14011_RS10295_lassopeptide

AHNHGTLWDGVFPTTSP

AH HGTLWDG+FPTTSP

AHGHGTLWDGIFPTTSP

61.1%

NZ_CP049017.1:

Lassopeptides: G4Q83_RS07645_lassopeptide

AHNHGTLWDGVF-PTTSP

AHNHGT + F TTSP

AHNHGTFLEASFIATTSP

with 5 more sequence matches

29.2%

NZ_CP033362.1:

Lassopeptides: EB232_RS01185_lassopeptide

TLWDGVFPTTSP

T DGVFP +P

TALDGVFPIHTP

22.2%

NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

WDGVFPTTS

W GV PT S

WQGVVPTVS

22.2%

NZ_CP049223.1and 4 others:

NZ_CP049225.1 Lanthipeptides: G6Z85_RS06555_lanthipeptideNZ_CP049228.1 Lanthipeptides: G6Z83_RS06555_lanthipeptideNZ_JAKWZB010000003.1 Lanthipeptides: MMO78_RS01405_lanthipeptideNZ_PNGO01000002.1 Lanthipeptides: CJ224_RS02730_lanthipeptide

Lanthipeptides: G6Z86_RS06445_lanthipeptide

WDGVFPTTS

W GV PT S

WQGVLPTVS

22.2%

NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

LWDGVFPTTS

W GV PT S

FWQGVVPTVS

13.9%

NZ_CP015883.1and 1 other:

NZ_JAASJP010000011.1 Lanthipeptides: allorf_43013_43183_lanthipeptide

Lanthipeptides: allorf_0205278_0205448_lanthipeptide

NHGTLWDGVF

N+G +W+ VF

NNGCMWNTVF

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.83 out of 23.79

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

Additional weak hits (12):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.07 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.01 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.96 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.93 out of 32.74

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.23 out of 27.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.38 out of 29.65

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.28 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.78 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.30 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.01 out of 33.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

N440_RS20340 - Class II: Cleavage pHMM score: 10.60; RODEO score: 23; Monoisotopic mass: 1817.8 Da; Molecular weight: 1818.9 Da; Number of bridges: 0

RRE predictions

: RRE type: Lasso_Fused_RRE; Location: 5 - 76; Score: 57.9

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence

NZ_SOCO01000001.1 - Region 4 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 2,027,200 - 2,075,567 nt. (total: 48,368 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

N440_RS09435: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

N440_RS09475: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

N440_RS09495: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

Hydrolases: hydrolase

N440_RS09450: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

N440_RS09460: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

N440_RS09440: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

N440_RS09455: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002689.2	1.25	NRPS	2,3-dihydroxybenzoylserine	Stenotrophomonas maltophilia K279a
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000343.5	0.62	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002689.2	0.85	NRPS	2,3-dihydroxybenzoylserine	Stenotrophomonas maltophilia K279a
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000343.5	0.65	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 26.33 out of 26.33

Confidence: strong

Additional weak hits (22):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.87 out of 20.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.47 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.63 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.81 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.35 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.98 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.08 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.16 out of 32.74

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.00 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.59 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.18 out of 32.74

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.91 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.81 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.77 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.48 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.58 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.91 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.56 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.92 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.35 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 2027199 - 2075567:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

N440_RS09440: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFFTSGEHNLYGPTEAAVDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

N440_RS09455: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (39..444): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SASLFPMSSPGGGLQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator

NZ_SOCO01000001.1 - Region 5 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 2,665,152 - 2,686,030 nt. (total: 20,879 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

N440_RS12365: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

N440_RS12365: PT_FPPS_like

Domain 1 (32 - 292): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.46 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.63 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.42 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.54 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.11 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein