LOCUS       NZ_SOCO01000001        20879 bp    DNA     linear   CON 06-MAY-2024
DEFINITION  Stenotrophomonas sp. CC22-02 N440DRAFT_scaffold00001.1, whole genome
            shotgun sequence.
ACCESSION   NZ_SOCO01000001
VERSION     NZ_SOCO01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Stenotrophomonas sp. CC22-02
  ORGANISM  Stenotrophomonas sp. CC22-02
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Stenotrophomonas.
REFERENCE   1  (bases 1 to 3925441)
  AUTHORS   Currie,C.
  TITLE     Bioprospecting for lignincellulytic microbes and enzymes from
            natural, highly-evolved plant biomass-degrading systems
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3925441)
  AUTHORS   Currie,C., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: AllPaths v. r42328
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004365115.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 02:50:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,030
            CDSs (total)                      :: 3,948
            Genes (coding)                    :: 3,927
            CDSs (with protein)               :: 3,927
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 21
            CDSs (without protein)            :: 21
            Pseudo Genes (ambiguous residues) :: 0 of 21
            Pseudo Genes (frameshifted)       :: 8 of 21
            Pseudo Genes (incomplete)         :: 13 of 21
            Pseudo Genes (internal stop)      :: 2 of 21
            Pseudo Genes (multiple problems)  :: 2 of 21
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:44:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2665151
            Orig. end                         :: 2686030
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SOCO01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20879
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="5"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20879
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20879
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10879](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10879
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(563..1807)
                     /locus_tag="N440_RS12320"
                     /old_locus_tag="N440_2477"
     CDS             complement(563..1807)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005410514.1"
                     /locus_tag="N440_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2477"
                     /product="DUF418 domain-containing protein"
                     /protein_id="WP_133935239.1"
                     /transl_table=11
                     /translation="MADLPDGCPVNAASHPLQPMASAERIAVLDILRGAALLGILLMNI
                     EAFSGPLDLAFTGIDVHWQGIDYWADAFVYVFVQGKFFTLFSLLFGAGFAVMAQRADVA
                     GRDFTPFYLRRSAGLLLIGLCHALLVWSGDILVMYALISLPLLACREAPRSWLPWMGVI
                     VYLGGAAMMLLVGAMVSMASADEVQGMLSEAQQSIELQRQVYGQGSWGQATVQRLSEFG
                     TSMGALLITGPEVLGMFLIGSWFAGSGALAAPERFPRLYTSLRWIALPLGLLVTLIGVA
                     WKPYLAPGTYNLPVTAAMALVTVGGLPMCLGYLAWIVHWRTRLAWLAPVGRMALTHYLG
                     QSLLCTWIFYHYGLGRFEMMPRSVQLLFALLLFAVQVGVSHVWLRHFRFGPMEWLWRAM
                     TYRQWPPMRRGAGLG"
     gene            complement(1907..2389)
                     /locus_tag="N440_RS12325"
                     /old_locus_tag="N440_2478"
     CDS             complement(1907..2389)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010482989.1"
                     /locus_tag="N440_RS12325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2478"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_133935240.1"
                     /transl_table=11
                     /translation="MKIEKDRVVRFHYTVSEVGQEPIESSKDRGEPLAILIGHGNIIPG
                     LENAMMDKEAGAAFSVDVTAADAYGERREGLSQRVPKKHFGNTKLAPGQQVVLQTNFGP
                     RAVTVQKVGMSVVDVDLNHPMAGKDLHFDVEIVDVREAGQEEIDHGHVHGDGGHHH"
     gene            2501..3040
                     /locus_tag="N440_RS12330"
                     /old_locus_tag="N440_2479"
     CDS             2501..3040
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014038010.1"
                     /locus_tag="N440_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2479"
                     /product="C40 family peptidase"
                     /protein_id="WP_053509406.1"
                     /transl_table=11
                     /translation="MHITPVSSGLRRLLAPALLLALPLLMTACGGGKATRPSAPPPTAH
                     WPKTVPDNPEAANSVLMRAISLVGTPYRYGGNTPDSGFDCSGLVAYVYREMLDLKLPRT
                     SRDLAAVQGPKIDPQRLATGDLVFFGSRGNVTHVGIYVGEGRFVHAPSTGGTVRLDSLS
                     GPYWKDHYTGAKRVLR"
     misc_feature    complement(3053..3066)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.45"
                     /tool="antismash"
     misc_feature    3066..3081
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    3107..3120
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.46"
                     /tool="antismash"
     misc_feature    3149..3158
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     misc_feature    complement(3161..3176)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            3238..3945
                     /locus_tag="N440_RS12335"
                     /old_locus_tag="N440_2480"
     CDS             3238..3945
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003475603.1"
                     /locus_tag="N440_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2480"
                     /product="C40 family peptidase"
                     /protein_id="WP_230078916.1"
                     /transl_table=11
                     /translation="MLGLALCLTSLPAWSQTAPNRSDVTPAPVAESPARPAAKAEAAAP
                     QRSRVDAAASATLAALLPHLAANDTIPLMDRSAVVAGDLSRLLANYDTSSAANGSVVGT
                     AADNGKVQSLLRRAMTLLGTPYRWGGSNPDSGFDCSGLVGYVFRSALGIELPRVSREMA
                     HDDNAELINDRTALAAGDLVFFGRKGRVDHVGIYVGDGRFLHAPSSGKDVRVDTLLSGY
                     WGNKFMQARRVDL"
     gene            complement(4174..5508)
                     /locus_tag="N440_RS12340"
                     /old_locus_tag="N440_2481"
     CDS             complement(4174..5508)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014038012.1"
                     /locus_tag="N440_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2481"
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="WP_133935241.1"
                     /transl_table=11
                     /translation="MKLVSAWLRIPFWQRVVGGFVLGALAGWALGPAAETWFGPLGELY
                     VTLIKMIAVPLVFFAVINAISSLHGQKSVAALSGRTFLWFVITAALAVCVGLGVGTVLQ
                     PGAGGLQLSMASNYVPREVPSVVQVLLDVVPANVFYALSGIGTKVNAAGETVLAAGRGS
                     ILPVIFFAGLVGFAIVKLGEKVTEARKLVGQMSDIMIQVTRFVLEVTPIGTFGLIAGLV
                     GSYGFEKLLPLGHFVLALYVACALHIVVVYSALLLAHGLNPLKFFRGAAPGMQVAFVSS
                     SSFAAMPVALRSITHNLGVNKDYGSFAVPLGASIKMDGCGAIYPALCAVFIAQYSGVPL
                     TPEQYVVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLETIGYLYAIDRILDMMRT
                     MTNVTGQMLVPVIVAKETGLLDQAVYDNPSGNVGVDDPDPTPPRG"
     gene            5662..7368
                     /locus_tag="N440_RS12345"
                     /old_locus_tag="N440_2482"
     CDS             5662..7368
                     /EC_number="3.1.3.1"
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019660635.1"
                     /locus_tag="N440_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2482"
                     /product="alkaline phosphatase"
                     /protein_id="WP_133935242.1"
                     /transl_table=11
                     /translation="MRRSVSLLAACATTLLLGACASTAPASAPAGLKVAVDPVAHPAGE
                     TPQWWYRSGAAQAAANGAMSGKARNVILFLGDGMSLTTVAASRIYEGQQKGGSGEENLL
                     SWERFPATAFSKTYNTDSQTPDSAGTMTAITTGVKTHMGAIGVSAGSRTDCADSLSKGL
                     LTWLQLADSAGLATGVVSTARLTHATPAATYANSPERNWENDTDLTEAAKAAGCKDIAQ
                     QLLSTSRYGRGPLVALGGGRGEFTTVEERDPEYDDKVGQRLDGRSLVQEWQQAHPQGAY
                     VWNSKQLAAAANAPAILGLFEPDHMRYEYERPQDPGGEPSLAELTAAAIKNLAKHPEGY
                     VLMIEGARIDHANHSGNAYRALTETVALSDAVRVANELTSADDTLIIVTADHSHTLNFV
                     GYPARGNPILGKVKDKGGEDGAGKLDYALDGSGQPYTTLTYANGPGHTGASNQQPAGAK
                     RYPHNPSSFEPANGRPNLREVDTEHPDYMQEALVPMKAESHGGEDVGIWARGPGSKAIR
                     GTLEQNAIYHMIVQATPALRERLCQAGTCDDKGVPVQLPVPTTFERKAEAK"
     gene            7365..7910
                     /locus_tag="N440_RS12350"
                     /old_locus_tag="N440_2483"
     CDS             7365..7910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019660636.1"
                     /locus_tag="N440_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2483"
                     /product="WG repeat-containing protein"
                     /protein_id="WP_133935243.1"
                     /transl_table=11
                     /translation="MIARQARPAPTSDRLARSLVLLGMLASSSALAQAPACKLLTDEHG
                     LWPLPDCEVVDHRPRIHPDTLKDLNFDDHGLAVVYADQGFHYVNRKGRSLPVLTWDNGP
                     ETPQEGLLRARVGNRVGYFDLKFRQVVPGTFDFGWPFRDGVAEVCNGCRRGTPDGDGHT
                     PMEGGERFRIDRSGRRVK"
     gene            8428..9714
                     /gene="tilS"
                     /locus_tag="N440_RS12355"
                     /old_locus_tag="N440_2484"
     CDS             8428..9714
                     /EC_number="6.3.4.19"
                     /GO_function="GO:0016879 - ligase activity, forming
                     carbon-nitrogen bonds [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tilS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005418067.1"
                     /locus_tag="N440_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2484"
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="WP_208322785.1"
                     /transl_table=11
                     /translation="MTAFPALVPLDAPLLVGYSGGVDSTVLLHWLWRCAQTSGTPLRAV
                     HVHHGLHADADDWVLHCRQQCAALGIELAVHHVRIDDTAGLGLEGAARQARRAAFAAEL
                     RDGETLALAQHQDDQAETFLLRALRGSGVDGLAAMSAHSRLGRHSLWRPLLQVPRDALL
                     DYARQHALHWVEDPSNADDHADRNFLRLQVLPLLRQRWPHAAAALAGSAAHCAQTRELL
                     DEEDAELIAHLEVAPRVLSLQLLRQISPGRAARVLRAWVLGHGAAPLPATVLQQALAEL
                     LPADNDRQARVGWHDHAIQQWRDHAYLLPARLPVLPRDWQAEWDGRMPLALPDGGQLRL
                     QGAAAFEHALQVRARVGGERIQLPGRQHSHALKDCLQREHLAPWRRAQLPLIFDGPQLL
                     AAADVVIAAPLQAWLQAHGAQLQWRPGGW"
     gene            9751..10011
                     /locus_tag="N440_RS12360"
                     /old_locus_tag="N440_2485"
     CDS             9751..10011
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005410522.1"
                     /locus_tag="N440_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2485"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_010482975.1"
                     /transl_table=11
                     /translation="MAKKSPENASPVAQFEQSLESLEQLVEQMETGELSLEASLSAYER
                     GVGLYRQCQQALEQAELRVRLLSDPAQPEAAEPFDPPSHDG"
     gene            10001..10879
                     /locus_tag="N440_RS12365"
                     /old_locus_tag="N440_2486"
     CDS             10001..10879
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008264747.1"
                     /locus_tag="N440_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2486"
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_049457993.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.2e-66, bitscore:
                     221.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEALFARWRDRIESQLDAALPSPAEAPQGLHQAMRYSVLGGGK
                     RMRPLLVYASGHLFGAQPEALDAAAMAVELIHAYSLVHDDLPAMDDDALRRGKPTTHIA
                     FDEATAILAGDALQARAFGLLADAPLPATLRVACLQTLAHASGAAGMCGGQALDIDATG
                     QQQTLAALTRMHALKTGALIRAAVRMGALCGQAHEPQLAQLDSFADALGLAFQVRDDIL
                     DVEASSEQLGKTAGKDQAQDKSTFPALLGMDGAKAQLRELAARMQSILAGHGEEADALR
                     ALATLAVERDH"
     gene            complement(10972..11343)
                     /locus_tag="N440_RS12370"
                     /old_locus_tag="N440_2487"
     CDS             complement(10972..11343)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014647933.1"
                     /locus_tag="N440_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2487"
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_049457994.1"
                     /transl_table=11
                     /translation="MSEFDNVPPPPATTDAPADQRTMALAAHLLGIFTWFIGPLIIWLI
                     NKDDASKAFVTDQAKEALNFQITITIAMLICIVLTIVIIGGILAPIVGILNLVFCIIAA
                     VKANNGEAYRYPFALRLVK"
     gene            complement(11431..12798)
                     /gene="pmbA"
                     /locus_tag="N440_RS12375"
                     /old_locus_tag="N440_2488"
     CDS             complement(11431..12798)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pmbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019662101.1"
                     /locus_tag="N440_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2488"
                     /product="metalloprotease PmbA"
                     /protein_id="WP_133935245.1"
                     /transl_table=11
                     /translation="MNVIAPEVAVGDDSPARLERLADLSQQLLDRARALGASQAEVSCS
                     EDRGLEVNVRLGEVETVQSTRDRGIAVTVYFGQRKGSASTGDLNEASLAATVEQACAIA
                     RHTEDDPAAGLAEAALMARDFPDLDSWHPWALQADEAVDLALACEQAGRGADARISNSD
                     GASVSSMQSVSVYANSHGFIGRERGTHHSVGCALIAGTGDGMQRDGWYTGGLAREDLEA
                     ADSVGRRAAERTVARLQPRSLPTGSMPVLFSPEVARSLVGHLLSAVSGGALYRQASFLL
                     DSVGQRLFPEWMQIEELPHLRRGLRSAAFDGDGVATRASALVSDGVLQRYVLGSYSARK
                     LGLQTTANAGGVHNLQLAANAGSLQEIARQMGDGLLVTELMGQGVNGVTGDYSRGAGGF
                     RVENGEIQYPVDGITIAGNLREMFSSIEAVGSDVDPRSHIRTGSILLGRMTIAGND"
     misc_feature    12842..12851
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.42"
                     /tool="antismash"
     misc_feature    12843..12856
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.54"
                     /tool="antismash"
     gene            12867..13454
                     /gene="yjgA"
                     /locus_tag="N440_RS12380"
                     /old_locus_tag="N440_2489"
     CDS             12867..13454
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yjgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019338623.1"
                     /locus_tag="N440_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2489"
                     /product="ribosome biogenesis factor YjgA"
                     /protein_id="WP_049457996.1"
                     /transl_table=11
                     /translation="MRGRDEETGEFHDKSRSQNRRDALDVLALGEKLVSLTPAQLARLP
                     IPEDLLPHIAECKRITAHIAHKRQLAFLAKHMRREEDATLDAIRDALDANSETGRREVA
                     MMHRAEDWRERLLAEGDTALAALLNDYPQADRQQLRTLVRNAQAEKAKNKPPRAYREIF
                     QVLRGLMLPAALGLKTADDEDTGVETGEADED"
     gene            complement(13496..14941)
                     /gene="tldD"
                     /locus_tag="N440_RS12385"
                     /old_locus_tag="N440_2490"
     CDS             complement(13496..14941)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="tldD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007972594.1"
                     /locus_tag="N440_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2490"
                     /product="metalloprotease TldD"
                     /protein_id="WP_133935246.1"
                     /transl_table=11
                     /translation="MTDIALTLAQDRLLRPGGLDTAGLERTFGQLLGPGVDFGDLYFQH
                     ARRESWSVEDGIVKDGAHSIEQGVGVRAISGEKTGFAYSDDIHADALRVAAQSARAISR
                     EGGAQSGRSLLRGNARALYPALDPIDGIGNEAKVEVLKRLDGYLRAADPRVKQVMVSLS
                     GGVDTVLIARSDGVLGADVRPLVRLNVQVIVEHNGRRESGYAGGGGRYGYAELFADGRP
                     EAFAREALRQALVNLEAVPAPAGVMPVVLGPGWPGVLLHEAVGHGLEGDFNRKGTSVYA
                     GRIGERVAAPGVTIVDDGTLEGRRGSLNIDDEGHPSQCTTLIEDGILVGYMQDSLNARL
                     MGVAPTGNGRRESFAHLTMPRMTNTYMRAGQHDPQEMIRSVKKGLYAVNFGGGQVDITS
                     GKYVFSATEAYLIEDGRITTPVKGATLIGNGPETMQKVRMVGNDLALDEGVGICGKDGQ
                     SVPVGVGQPSLLIEGITVGGTQA"
     misc_feature    14937..14951
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(14984..14998)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            complement(15002..18847)
                     /locus_tag="N440_RS12390"
                     /old_locus_tag="N440_2491"
     CDS             complement(15002..18847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014647937.1"
                     /locus_tag="N440_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2491"
                     /product="YhdP family protein"
                     /protein_id="WP_133935247.1"
                     /transl_table=11
                     /translation="MSAPPRLRLRRIRRHFIAACAVGLVGLALLVGSISQLLPLAERHP
                     DRVAAWLSERAGQPVRFDQLQTAWTRRGPLLQLKGLRIGAGQGLAIGEAEVLVSMYSGL
                     LPGRSLTELRLRGLALDLQQGEDGRWSVRGLPQSTSGGDPLDALRRLGELQVIEGRLGV
                     HAPDLGIDTTLPRIDLRLRVNGDRLRVGVRAWAQADALPLTAVLDVDRVRGNGQAWLGA
                     DPVDFHAWSPLLAAGGVRLREGKGELNLWLTLRDFAPVALTTDSDLREVRIDGAPMPDV
                     AVPQLQLQRLQARLRWQRQADGWALQVPRLRLKTEDGEQQLDGLQLQVGRQLRVSSGDV
                     QAGTALRALALSDRLDPGLRHWLFLSRPQLDVRELQLSGQRDGPLWAQGELKSLGFASV
                     GHSPGLRGLGGRFEGDADGFSLQLQPRQQLQFDWPTGFGVRHDLHLAGQVVGWRDEAGG
                     WRIGTAAMRVEGTDYAADVRGGVWFQGDGTRPWLQLAAKLDDVPMTAAKRFWIHSRMSK
                     GATDWLDMALAGGQVRNGVGLVSGDLDDWPFDNNDGRFEATGHITNGDIRFQHDWPLMS
                     QVDADIAFIGPGFDMHGRGDLAGVAVQTFEAGIPDFGQQPLYVRADAQSEAGKLLAMLR
                     QSPLHKDYGDTLDNLTAAGPAHVTFDLLQPLHLDEGEGHLQGTVDLNGVKLVDKRFQLT
                     FDNMHGQARYGNGGFDAEELAVRHLGQDGRLSLRAGSYVRDSKLAFESLLSANLDAGVL
                     IDRAPEMAWLKPYIAGTSPWTIAVNLPKVAPGAPAPPSELRLSSDLVGTRLDLPAPLDK
                     PAGEPLATTVAAQLPMGAGRIDVAFGQRLALAARSHNNRTGVQVTLGSDHVDREPPPSG
                     LAVNGRSPTLDALEWISLARGGGEDDGMPLRAVDVQVGKLMLIGGVFEQTRLQLQPGAQ
                     ALDVRLDGPSLAGRLSVPNAEGGTISGQLERVYWQSLPAAAGAPAAPARVQAGANDMDP
                     AKLPPFALDIADLKFGKVVLGQAVLRTRPLANGLNVDELRFRAPDQEIDINGRWLGRTG
                     GARTELTAQVRSEDLGGLMQNLDYGGQLRGGSGQAQLQASWSGGPSDFQLAQLQGRLDL
                     HARNGQLLELEPGAGRVLGLLSVTQLPRRLMFDFRDFFSKGFAFNQVDGSVQFGQGMAR
                     TDKVLIEGPAANITIRGQADLRNQQFDQTIDVNPRAGNLLTVVGAVAGGPVGAALGAAT
                     NAVLSKPLGEIGARTYKVTGPWKEPKVEVIERSRDKAPPAPAPGIPPTVTDLPRSR"
     gene            complement(18878..20365)
                     /gene="rng"
                     /locus_tag="N440_RS12395"
                     /old_locus_tag="N440_2492"
     CDS             complement(18878..20365)
                     /EC_number="3.1.26.-"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rng"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002802933.1"
                     /locus_tag="N440_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N440_2492"
                     /product="ribonuclease G"
                     /protein_id="WP_008264487.1"
                     /transl_table=11
                     /translation="MSEEILVNVTPRETRVAVIENGMLQELHIERGWRRGVVGNIYKGK
                     VQRVMPGMQAAFVEVGLERAAFLHANDVVRPAPVASADTENTTLPPPASVPIVELLRDG
                     QDIVVQVVKDPIGTKGARLTTQISIPSRYMVLLPQSKVVGVSARIEDETERARLKALVT
                     ELSAQHGGYGYIVRTNAEGQPAEAIAEDIAYLSRVWNVVERRGREAASCSIIYEDLSLP
                     LRSVRDLIRKDVDKVKVDSKETFGQLQAFVAKYMPVLAEKLELYSGDRPIFDMFGVEDE
                     IGRALDKQVPLKSGGYLVIDQTEAMTTIDVNTGSFLGQRNLEETVFRTNLEAAQAVARQ
                     LRLRNLGGIIIIDFIDMDDAEHRRQVLRTLEKALARDHAKTTVYDFSPLGLVEMTRKRT
                     VESLERQLSETCPQCSGRGSIKTTETVTYEIFREITRAVRQFDAARLLVIASTKVVARI
                     TDEESSAVAELEEFLGKSIRFQADEQYLQEQFDVVLL"
ORIGIN
        1 ggcgatcgtg gaaggccgga ttcgcgcgcg catagtcggc accaccgatg caggccgtgg
       61 cgatgccctg tgcgttcagc gccgcgcatt cggccacatg gtggtcgaag ttgcgtgcat
      121 cgccgaacac gtagtccagc ccgcgcgcat caaattcgca gtcaagcgca tgtgcctgca
      181 cccactcggc caggcgctgc cgcgaatcat ccagcagcgc accacgtgca cgcgtggact
      241 gcagccagtc gcgggcgttg cagcgtgcac caaactgcag cagccagcgc cacagcgtgg
      301 gatccagccg cgtacgcacg tacagcggcg cgcgcggatc aagcatccag cgcaacgcgc
      361 gcagcggtac cccgggcgcc gccagtggcg gtgcgtggct gggggtgatc gtgccgcagt
      421 tgccatgcga cgtcgcccct ccgacgcgcc cccgctcgat cacgcgcacc tgccggccgt
      481 gcgcgcgcag tgcaagcgca gtggccagac cgatggcgcc ggcaccgacc acgatcacgt
      541 cctcgcgcgc cctcgacatc gatcagccca gcccggctcc gcgccgcatc ggcggccact
      601 gccggtaggt catcgcacgc cacagccatt ccatgggccc gaaacggaag tggcgcagcc
      661 atacgtgcga gacgcccacc tgcacggcaa acagcagcag cgcgaacagc agctgcacac
      721 tgcgcggcat catctcgaac ctgcccagtc cgtagtggta gaagatccag gtgcacagca
      781 gcgactggcc gagatagtgg gtcaaggcca tgcggccgac cggcgccagc cacgccagcc
      841 gcgtgcgcca gtgcacgatc cacgccaggt agcccaggca catcggcagg ccgccgacgg
      901 tcaccagcgc catcgccgcc gtcaccggca ggttgtacgt gcccggtgcc aggtacggtt
      961 tccaggcaac accgatcaac gtgaccagca ggcccagcgg cagcgcgatc cagcgcagcg
     1021 aggtgtacag gcgtgggaag cgttccggcg cagcaagcgc gccactgccg gcgaaccagc
     1081 tgccgatcag gaacatgccc agcacttccg ggccggtgat cagcagcgcg cccatcgagg
     1141 tgccgaactc gctcaagcgc tgcacggtgg cctgtcccca gctgccctgc ccgtacacct
     1201 gccgctgcag ctcgatgctc tgctgcgctt cgctgagcat gccctgcacc tcgtcggccg
     1261 aggccatcga caccatcgca ccgaccagca gcatcatcgc cgcgccgccc agatagacga
     1321 tcacgcccat ccacggcagc caactgcgcg gcgcctcgcg gcaggccagc aacggaagcg
     1381 agatcagcgc atacatcacc aggatgtcac cggaccagac cagcagcgcg tggcacaggc
     1441 cgatcagcag cagtccggcg ctgcggcgca ggtagaacgg ggtgaagtca cgcccggcca
     1501 cgtcggcgcg ctgcgccatc accgcgaagc cggcgccgaa cagcagcgag aacagggtga
     1561 agaacttgcc ctgcacgaac acatagacaa aggcatcggc ccagtagtcg atgccctgcc
     1621 agtgcacgtc gatgccggtg aacgccaggt ccagcgggcc actgaaggct tcgatgttca
     1681 tcagcaggat gcccagcaac gcggcaccac gcaggatgtc cagcacggcg atgcgttcgg
     1741 cggaagccat cggctgcaag ggatgagaag cggcgttcac ggggcatccg tcgggcaggt
     1801 ccgccattat gccgccggcc cacgcgccat ggatgcccgc gccgtgttcc agaaacgcaa
     1861 cggcccgccg aagcgggccg ctgctgccat cacgatcgcg ctgcgatcag tggtggtggc
     1921 caccgtcgcc gtggacgtgg ccgtggtcga tctcttcctg gccggcttcg cgcacatcga
     1981 cgatctccac gtcgaaatgc aggtccttgc cggccatcgg gtggttcagg tcaacgtcga
     2041 ccacgctcat gccgaccttc tgcacggtca ccgcgcgcgg gccgaagttg gtctgcagca
     2101 cgacctgctg gcccggggcc agcttggtgt tgccgaagtg cttcttcggc acgcgctggg
     2161 acaggccctc gcggcgctcg ccgtaggcgt cggcagcagt gacgtcgacg ctgaaggccg
     2221 cgccggcttc cttgtccatc atggcgtttt ccaggcccgg aatgatgttg ccgtggccga
     2281 tcaggatcgc cagcggctcg ccgcggtcct tggacgattc gatcggctcc tggccgactt
     2341 cggaaacggt gtagtggaag cggacaacgc ggtctttttc gatcttcatg cgcaactctg
     2401 tctggatctg ccggaggcag gcgggttggg gcgggttgtc gcccggcggg gacgccgcca
     2461 tcatgacggc caatccaagg tggcgcatta tccggagatc atgcacatca cgccagtttc
     2521 gtccggcctg cgccggctcc tcgccccggc cctgctgctg gccctgcccc tgctgatgac
     2581 cgcctgtggc ggcggcaagg ccacccggcc ctcggctccc ccgccgaccg cccactggcc
     2641 gaagaccgtg ccggacaatc ccgaggccgc caactcggtg ctgatgcgtg ccatcagcct
     2701 ggtcggtacg ccctaccgct acggcggcaa cacccccgat tccggcttcg actgcagcgg
     2761 cctggtcgcc tatgtctacc gcgagatgct ggacctgaag ctgccgcgca cctcgcgcga
     2821 cctggcggcg gtacagggcc cgaagatcga cccgcagcgc ctggccaccg gcgacctggt
     2881 gttctttggc agccgcggca acgtcaccca tgtcggcatc tatgtgggcg aaggacgttt
     2941 cgtgcacgcc ccaagcaccg gcggcacggt ccggctggac tcgctcagcg gcccctactg
     3001 gaaggaccac tacacaggcg cgaaacgtgt ccttcgctaa aatgaacagg cgatatgttc
     3061 aaaaatgtga cgcacatcac tatggaacta acggattact aacggaattt ttaacttatt
     3121 gacgctttta caaggcatga tgccccatcg tttttttcct gtgaccgacg cgtgacgact
     3181 gacgacctga aaagcgaagg ccagacttcc gtatcttcac gtagtgcccg cccgctgttg
     3241 cttggcctgg cactgtgtct gaccagcctt ccggcctggt cgcagactgc tccgaatcgt
     3301 tccgatgtga ctccggcccc ggtggccgag agccccgccc gaccggccgc caaggccgag
     3361 gctgccgctc cgcagcgcag ccgcgtcgat gccgccgcca gcgcgaccct ggctgccctg
     3421 ctgccgcacc tggcggccaa cgacaccatt ccgctgatgg accgctcggc cgtggtggcc
     3481 ggcgatctca gccgcctgct cgccaactac gacaccagca gcgccgccaa tggcagcgtt
     3541 gtcggtaccg ccgccgacaa cggcaaggta cagtcgctgc tgcgccgtgc gatgaccctg
     3601 ctgggcaccc cgtaccgttg gggtggcagc aacccggaca gcggtttcga ctgcagcggc
     3661 ctggtcggct acgtgttccg ctccgccctc ggcatcgagc tgccgcgcgt ctcgcgcgag
     3721 atggcccacg atgacaacgc cgaactgatc aacgaccgca ccgcgctggc tgccggcgac
     3781 ctggtgttct tcggccgcaa gggccgcgtg gaccacgtcg gcatctacgt cggtgacggc
     3841 cgcttcctgc acgccccgag ctcgggcaag gacgtgcgcg tggacaccct gctcagtggc
     3901 tactggggca acaagttcat gcaggcccgc cgggtcgatc tctgatctga ccggttggcg
     3961 cgaccgcgcc gcctgacacg agaaagccgc tgccctgcag cggctttttt gttgggcgcg
     4021 cacggtggtg ggtgccgacc ttggtcggca ctgccttcat ccatgcatgg catggatcta
     4081 ccagggccta ccctctgccc ggcaccgcat cagccacccg ccaagcaaaa ggcccgccgg
     4141 gtcagggcgg gcctttcata tcgctacgca acctcagccg cgtggcggtg tcgggtcggg
     4201 gtcatccacg cccacattgc cggacgggtt gtcgtacacc gcctgatcca gcaacccggt
     4261 ttccttggcc acgatcaccg gcaccagcat ctggccggtc acattggtca tcgtgcgcat
     4321 catgtccagg atgcggtcga tggcatacag gtagccgatg gtctccagcg gcaggttggc
     4381 tgcactcagc accaccgtgg ccatgatcac cgcggtgccc ggcacgccgg cggtgccgaa
     4441 gctgcccagc accgaggcga tcagcaccac cacgtactgt tccggggtca gcggcacgcc
     4501 gctgtactgc gcgatgaaca ccgcgcacag cgccgggtag attgcgccgc agccgtccat
     4561 cttgatgctg gcccccagcg gcaccgcgaa cgaaccgtag tccttgttca cgcccaggtt
     4621 gtgggtgatc gagcgcagcg caaccggcat cgccgcgaag ctggacgagc tgacaaacgc
     4681 cacctgcatg cccggtgccg cgccacggaa gaacttcagc gggttcaggc cgtgtgccag
     4741 cagcagcgcg ctgtagacca ccacgatgtg cagcgcgcag gccacgtaca gcgccagcac
     4801 gaaatggccc agcggcaaca acttctcgaa cccgtagctg ccaaccaggc cggcgatcag
     4861 gccgaaggta ccgatcgggg tgacttccag cacgaagcgg gtcacctgga tcatgatgtc
     4921 gctcatctgg ccaaccagct tgcgcgcctc ggtcaccttc tcgcccagct tgacgatggc
     4981 aaagcccacc agtccggcga agaagatcac cggcaggatc gagccgcgac cggcggccag
     5041 cacggtttca ccggccgcat tgaccttggt gccgatgccg gacagcgcat agaagacatt
     5101 ggccggcacc acgtccagca gtacctgcac cacgctgggc acttcgcgcg gcacatagtt
     5161 gctggccatc gacagctgca ggccaccggc gccgggctgc agcaccgtac ccacgcccag
     5221 gccgacgcac accgccagcg cggcggtaat cacgaaccac aggaaagtgc ggccactgag
     5281 cgcggcaacc gacttctggc cgtgcagtga cgagatcgca ttgatgaccg cgaagaacac
     5341 cagcggtacc gcgatcatct tgatcagggt gacgtacagc tcgccgagcg ggccgaacca
     5401 cgtttccgcg gccgggccca gcgcccagcc ggcgagcgca ccgagcacga agccaccgac
     5461 cacgcgctgc cagaatggaa tccgcagcca ggcagagacc agcttcatag gcaatccaga
     5521 ggggaagaag ggatgctgga acgatagccc aaggcggccg gcagaacgac cgcccggccg
     5581 gcaaatcagt gtgtcatcgg cgtgccttgc ggggccgggc ataatgaacg tcccgttaca
     5641 gtttgtgaga tcccagcgtc catgcgtcgt tccgtctccc tgttggccgc ctgcgccacc
     5701 accctgctgc tgggcgcctg cgccagcact gcccccgcgt ccgccccggc cggcctcaag
     5761 gtcgctgtcg atcccgtcgc ccacccggcc ggtgagaccc cgcagtggtg gtaccgcagc
     5821 ggcgccgccc aggcggccgc caacggcgcg atgtccggca aggccaggaa cgtcatcctg
     5881 ttcctgggcg acggcatgag cctgaccacc gtggccgcct cgcgcatcta cgagggccag
     5941 cagaagggcg gttcgggcga agaaaacctg ctgtcctggg agcgcttccc ggccacggcg
     6001 ttcagcaaga cctacaacac cgattcgcag acgccggatt cggccggcac catgaccgcc
     6061 atcaccaccg gcgtgaagac ccacatgggt gcgatcggcg tcagcgccgg cagccgcacc
     6121 gactgcgccg acagcctgtc caagggcctg ctgacctggc tgcagctggc cgacagcgcc
     6181 ggcctggcca ccggcgtggt gtccaccgcc cgcctgaccc acgccacccc cgccgccacc
     6241 tacgcgaact cgcccgagcg caactgggaa aacgacaccg acctgaccga agcggccaag
     6301 gcggccggct gcaaggacat cgcccagcag ctgctgtcga cctcgcgcta tggccgtggc
     6361 ccgctggtcg ccctcggcgg cggtcgcggt gaattcacca ccgtggaaga gcgcgatccg
     6421 gaatacgacg acaaggtcgg ccagcgcctg gacggccgca gcctggtgca ggaatggcag
     6481 caggcacatc cgcagggtgc ctatgtctgg aacagcaagc agctggcggc cgccgccaac
     6541 gcgccggcca ttctcggcct gttcgagccg gaccacatgc gctacgagta cgagcgcccg
     6601 caggatccgg gcggcgagcc gagcctggcc gaactgaccg ccgcggcgat caagaacctg
     6661 gccaagcacc cggaaggcta cgtgctgatg atcgagggcg cgcgcatcga ccacgccaat
     6721 cacagcggca acgcctaccg tgccctgacc gagaccgtag ccctgtccga cgcggtgcgc
     6781 gtggccaatg aactgacctc ggccgacgac accctgatca tcgtcaccgc cgaccactcg
     6841 cacaccctga acttcgtcgg ctacccggca cgcggcaacc cgatcctggg caaggtgaag
     6901 gacaagggcg gcgaagacgg tgccggcaag ctggactatg cgctggacgg cagcggccag
     6961 ccgtacacca ccctgaccta cgccaacggc ccgggccata ccggcgccag caaccagcag
     7021 ccggccggcg ccaagcgcta cccgcacaac ccgagcagct tcgaaccggc caatggtcgc
     7081 ccgaacctgc gtgaggtcga caccgagcat ccggactaca tgcaggaagc gctggtgccg
     7141 atgaaggctg aatcgcacgg tggcgaggac gtcggcatct gggcacgcgg accgggcagc
     7201 aaggcgatcc gcggcacgct ggaacagaac gcgatctacc acatgatcgt gcaggccacc
     7261 ccggccctgc gcgaacgcct gtgccaggcc ggcacctgcg acgacaaggg cgtgccggtg
     7321 cagctgccgg tgccgaccac cttcgaacgc aaggccgagg ccaagtgatc gcgcggcagg
     7381 cccgccctgc ccccaccagc gaccgcctcg cgcggtcgct ggtcctgctc ggcatgctgg
     7441 ccagttccag cgcgctggcg caggcgccgg cctgcaaact gctgaccgac gagcacggcc
     7501 tgtggccgct gcccgactgc gaggtggtcg atcaccggcc caggatccac cccgacacgc
     7561 tgaaagacct gaacttcgac gaccacggcc tggccgtggt gtatgccgac cagggtttcc
     7621 attacgtcaa ccgcaagggc cgcagcctgc cggtactgac ctgggacaac ggcccggaga
     7681 cgccgcagga gggcctgctg cgggcccgcg tcggcaaccg cgtgggctac ttcgacctga
     7741 agttccgtca ggtggtgccg ggcaccttcg atttcggctg gccgttccgc gatggcgtgg
     7801 ccgaggtctg caacggctgc cgtcgcggca cgccggatgg tgatgggcac acgccgatgg
     7861 aaggcggaga gcgtttccgc atcgaccgct cgggccgtcg agtgaagtag ttttttcggc
     7921 agggctgcgc cctgcacctg ctgcaagcca gagcaacagc aacagcaaca gcaacagcaa
     7981 cagccggctc tgggttgtct gtgggtttgg cggggcggtg tcggattgcg gggacgccgt
     8041 gaacccatcc ctgggggctt ggccgcggca tccatgccgc ggacaccccg caatccgaca
     8101 ccgccccacc ttcgacaggt tcccgatgac ggatcgaaca tccacatcat tcatcgtcga
     8161 gatccatcag acatcgaaat tgatcgaatg agattcgaca gattgcggaa aactgtcgaa
     8221 ggcggggtgg gtccgggtgc gggaggggcc gcggcatgga tgccgcggcc aagcccccat
     8281 ggatgggttt acggcgtctc ccgcaaccgg acccaccccg ccatccctca ggaaacccgc
     8341 tgttgctgtt gctgttgctg ttgctgttgc tctggatcgt agcgggtgca gggcgcagcc
     8401 ctgccgacca accctatact tgcggccgtg actgccttcc ctgcccttgt tccgctggat
     8461 gcgccgctgc tggtcggcta cagcggcggt gtcgactcga ccgtactgct gcactggctg
     8521 tggcgctgcg cccagacctc cggcactccg ctgcgcgcag tacacgtgca ccacggcctg
     8581 cacgccgatg cggatgactg ggtgctgcat tgccggcagc aatgcgcggc gctgggcatc
     8641 gaactggccg tgcaccacgt aagaatcgac gacaccgcag gcctaggcct cgaaggtgct
     8701 gcgcgacagg cgcgacgcgc ggcgttcgcc gccgagctgc gcgacggtga aacgctggcg
     8761 ctggcgcagc accaggacga ccaggccgaa accttcctgc tgcgcgcgct gcgcggttcg
     8821 ggcgtcgatg gccttgctgc gatgtccgca cacagccgcc ttggcaggca ctccctgtgg
     8881 cgaccactgc tgcaggtacc gcgcgatgca ctgctcgact acgcccggca acacgcgctg
     8941 cactgggtcg aagaccccag caacgccgac gaccacgctg atcgcaactt cctgcgcctg
     9001 caggtgctgc cgctgctgcg ccagcgctgg ccacatgcgg ccgcggcgct ggccggcagc
     9061 gcggcgcatt gcgcgcagac ccgtgagctg cttgatgaag aagacgccga gctgatcgcg
     9121 catctggagg tggcaccgcg cgtgctgtcg ctgcagctgc tgcggcagat ttcacccgga
     9181 cgcgccgcac gcgtgctgcg ggcctgggtg ctgggccatg gcgcggcgcc gttgccggcc
     9241 acggtcctgc agcaggcact ggccgaactg ctgccggccg acaacgaccg ccaggcgcgc
     9301 gtggggtggc acgatcatgc gatccagcaa tggcgcgacc acgcctacct gctgcctgcc
     9361 cggctgcccg tactgcctcg cgactggcag gccgagtggg atggacgcat gcccctggcg
     9421 ttgcccgatg gcggccagct gcgcctgcag ggcgccgcgg ccttcgaaca cgcgctgcag
     9481 gtccgcgcac gcgtgggtgg tgagcgcatc cagctgcccg gacgccagca ttcgcacgcg
     9541 ctgaaggact gcctgcaacg ggaacacctc gcgccctggc gacgcgcaca gctgccgctg
     9601 atcttcgatg gcccgcagtt gcttgctgcc gccgacgtgg tcatcgccgc acctttgcag
     9661 gcctggttgc aggcccatgg ggcgcaactg cagtggcgtc ccggcggctg gtgaattgac
     9721 ccccgcgcgc ggcccgtcca cacttgccgc atggccaaga agtcccccga aaacgcctcc
     9781 ccggtcgccc agttcgagca gtcgctcgaa tcgctggagc agctggtgga gcagatggaa
     9841 accggcgagc tgagcctgga agcttcgctc agtgcttacg aacgtggcgt tggcctgtac
     9901 cgccagtgcc agcaggcgct ggagcaggcc gaactgcgcg tgcgcctgct cagcgatccg
     9961 gcccagccgg aagcggccga gccgttcgac ccgcccagcc atgacggctg aggccctttt
    10021 cgcgcgctgg cgcgaccgta ttgaaagcca gctcgacgcc gcactgccct cgcctgccga
    10081 ggcaccgcag ggcctgcacc aggccatgcg ctattcagtg ctgggcggcg gcaagcgcat
    10141 gcgcccgttg ctggtgtatg ccagcggcca cctgttcggt gcgcagccgg aagcgctgga
    10201 cgccgccgcg atggcggtcg aactgatcca cgcctattca ctggtgcatg acgatctgcc
    10261 ggcgatggac gatgacgccc tgcgtcgtgg caagccgacc acgcatatcg cctttgacga
    10321 agccacggcg atcctcgctg gcgacgccct gcaggcccgt gccttcggcc tgctggccga
    10381 tgcaccgctg ccggccacat tgcgcgtggc ctgcctgcag acgctggccc acgcctccgg
    10441 cgccgccggc atgtgcggcg gccaggccct ggacatcgat gccaccggcc agcagcagac
    10501 actggcggcc ctcacccgca tgcatgccct gaagaccggg gcgctgatcc gcgccgcggt
    10561 gcgcatgggt gcgctgtgtg gtcaggccca cgaaccgcag ttggcccagc tcgacagctt
    10621 cgccgatgca ctcggcctgg cgttccaggt gcgtgacgac atcctcgatg tcgaggccag
    10681 ttccgaacag ctgggcaaga ctgccggcaa ggaccaggca caggacaaga gcaccttccc
    10741 cgccctgctt ggcatggacg gtgcgaaggc ccagctgcgc gaactcgccg cacgcatgca
    10801 gtcgatcctg gccggccatg gcgaggaagc cgatgcgttg cgcgcgctgg cgacgctggc
    10861 ggtcgaacgc gatcattgat tgctgcgcgc tcgccaggta ccgcccgtca ctctccgcac
    10921 atgaaaacgc ccggcaatgc cgggcgtttt cagttccgca tgtggccgat cttacttgac
    10981 caggcgcagc gcgaacgggt agcggtaggc ttcgccgttg ttcgccttga ccgcggcgat
    11041 gatgcagaac accagattca ggatgccgac gatcggggcc aggatgccgc cgatgatcac
    11101 gatggtcagc acgatgcaga tcagcatcgc gatggtgatg gtgatctgga agttcagcgc
    11161 ttccttggcc tggtcggtca cgaaggcctt gctggcgtca tccttgttga tcagccagat
    11221 gatcagcggg ccgatgaacc aggtgaagat gcccagcagg tgcgcggcca gggccatggt
    11281 gcgctggtcg gccggcgcgt cagtggtggc cggcggcggc gggacgttat cgaattcact
    11341 cacgacaaaa ctccttttca ttgggtggtc ttgacccacc agcaccaagc tggtcgcgtc
    11401 aggcgcgcat agcttacgcc atcaatgcca tcaatcatta ccggcgatgg tcatccgtcc
    11461 cagcaggatc gaaccggtcc ggatgtgtga gcgcgggtcg acgtcgctgc cgaccgcctc
    11521 gatgctgctg aacatctcgc gcaggttgcc ggcaatggtg atgccgtcca ccgggtactg
    11581 gatctcgccg ttctcgacgc ggaagccacc ggcaccacgc gagtagtcgc cggtcacccc
    11641 gttcacgccc tgccccatca gctcggtcac cagcagcccg tcgcccatct ggcgcgcgat
    11701 ctcctgcaac gagccggcgt tggcggccag ctgcaggttg tgcacgccac cggcattggc
    11761 ggtggtctgc aggcccagct tgcgcgccga atagctgccc agcacgtagc gctgcagcac
    11821 cccgtcgctg accagggccg aagcacgggt cgccacgccg tcaccgtcga aggcggccga
    11881 acgcaggccg cggcgcaggt gcggcagctc ctcgatctgc atccactccg ggaacagccg
    11941 ctggccgaca ctgtcgagca ggaagctggc ctgccggtac agggcgccgc cggataccgc
    12001 cgacagcagg tggccgacca ggctgcgggc cacttccggg gagaacagca ccggcatgct
    12061 gccggttggc agcgaacgcg gctgcagccg ggccacggta cgctcggcgg cgcggcggcc
    12121 cacgctgtcg gctgcctcca ggtcctcgcg ggccaggccg ccggtgtacc agccatcacg
    12181 ctgcatgcca tcgccagtgc ctgcgatcag ggcgcagcca accgaatggt gggttccgcg
    12241 ctcgcggccg atgaagccat gcgaattggc atagaccgag acgctctgca tgctcgacac
    12301 cgaggcaccg tcggaattgc tgatgcgagc atcggccccg cgaccggcct gctcgcaggc
    12361 cagggccagg tccaccgctt cgtcagcctg cagcgcccag gggtgccagc tgtccaggtc
    12421 ggggaagtcg cgggccatca gcgccgcctc ggccagcccg gcagccgggt cgtcctcggt
    12481 gtgccgggcg atcgcgcagg cctgctcgac cgtggccgcc aggctggcct cgttcaggtc
    12541 gccggtgctg gcactgccct tgcgctggcc gaaatagacc gtcaccgcga tgccgcggtc
    12601 acgggtggac tgcacggtct cgacctcgcc gaggcggaca ttgacctcca ggccccggtc
    12661 ctcgctgcag ctgacctcgg cctggctggc acccagcgcg cgggcgcggt cgagcagctg
    12721 ctgggagagg tcggccagcc gttccaggcg ggccgggctg tcgtcgccga cggcgacttc
    12781 aggggcgatc acgttcaatg ctttatcctg tacaggttgg gcccggcatc acgccgggcg
    12841 actttttttg agatcaggta gggacgatgc gcggacgcga cgaagaaacc ggtgaattcc
    12901 acgacaagag ccgcagccag aaccggcgcg acgcgctcga tgtcctggcc ctgggcgaga
    12961 aactggtgtc gttgaccccg gcccagctgg cgcgcctgcc gatcccggaa gacctgctgc
    13021 cgcacatcgc cgagtgcaag cggatcaccg cccacatcgc ccacaagcgc cagctggcgt
    13081 tcctggccaa gcacatgcgt cgcgaagagg acgccacgct tgacgccatc cgcgatgcgc
    13141 tggacgcaaa cagcgaaacc ggccgccgcg aagtggcgat gatgcatcgc gcggaagact
    13201 ggcgcgagcg cctgctggcc gaaggcgaca cagcgctggc cgcactgctc aacgattacc
    13261 cgcaggccga ccgccagcag ctgcgcacgc tggttcgcaa tgcccaggcc gagaaagcga
    13321 agaacaagcc gccgcgtgcc taccgcgaga tcttccaggt gctgcgcggc ctgatgctgc
    13381 cggccgcgct gggcctgaag accgccgatg acgaagacac cggcgtggag accggcgaag
    13441 ccgacgagga ctgagtccgc gccggcgtgg gcggtggcgc tggccatcgc ccggctcagg
    13501 cctgggtacc gccgacggtg atgccctcga tcaacagcga aggctggccg acccccacgg
    13561 gcacactctg cccatccttg ccgcagatgc ccacgccttc gtcgagggcc aggtcgttgc
    13621 cgaccatgcg caccttctgc atggtttccg ggccattgcc gatcagggtc gcgcccttca
    13681 ccggcgtggt gatccggccg tcctcgatca ggtaggcctc ggtggccgag aacacatact
    13741 tgccactggt gatgtcgacc tggccgccgc cgaagttgac cgcgtacagg cccttcttca
    13801 ccgagcggat catttcctgc gggtcatgct ggccggcacg catgtaggtg ttggtcatgc
    13861 gcggcatggt caggtgcgcg aacgattcgc ggcgcccgtt gccggtcggt gccacgccca
    13921 tcaggcgggc attgaggctg tcctgcatgt agccgaccag gatgccgtcc tcgatcaacg
    13981 tggtgcactg gctcgggtgg ccttcgtcgt cgatgttcaa cgacccgcgg cggccctcca
    14041 gcgtgccgtc gtcgacgatg gtcacgcccg gcgccgcaac gcgttcaccg atgcggccgg
    14101 catagacgct ggtgcccttg cggttgaagt cgccttccag gccgtggccg accgcctcat
    14161 gcagcagcac ccccggccag cccgggccca gcaccaccgg catcacgccg gccggcgccg
    14221 gtaccgcttc gaggttcacc agcgcctggc gcagcgcctc acgcgcaaac gcttcaggcc
    14281 ggccgtcggc gaacagttcc gcatagccat agcggccacc gccaccggca tagccggact
    14341 cgcggcggcc attgtgctcg acgatcacct gcacgttcag gcgcaccagc gggcgcacgt
    14401 cggcgcccag cacgccgtcg ctgcgggcga tcagcacggt atccacgccg ccggacaggc
    14461 tgaccatcac ctgtttcacg cgcgggtccg cggcacgcag atagccgtcc aggcgcttga
    14521 gcacctcgac cttggcctcg ttgccgatac cgtcgatcgg gtccagcgcc gggtacagcg
    14581 cacgcgcatt gccacgcagc agcgagcgcc cggactgcgc gccgccttcg cgcgagatcg
    14641 cgcgcgccga ctgcgccgct acccgcagcg catcggcatg gatgtcatcg gagtaggcga
    14701 agccggtctt ctcgccggaa atcgcccgca cacccacgcc ctgctcgatg gaatgggcac
    14761 cgtccttgac gatgccgtcc tccacgctcc agctctcgcg gcgggcgtgc tggaagtaga
    14821 ggtcgccaaa gtcgacaccg gggccgagca gctggccgaa ggtgcgctcc aggccagcgg
    14881 tatccaggcc accggggcgc agcaggcggt cttgggcaag cgtcagggcg atatcagtca
    14941 tggctctcga tctggggatg cgggggcgcc gaggcaagcc ccgtgaacag gaaagccacg
    15001 ctcagcgcga gcgtggcagg tcggtgacgg tcggcggaat gccgggtgcc ggagcgggcg
    15061 gcgccttgtc gcggctgcgt tcgatcactt ccaccttcgg ctccttccat gggccggtca
    15121 ccttgtaggt acgggcgccg atctcgccca acggtttgga caataccgca ttggtggccg
    15181 caccgagtgc cgcgcccacc ggcccccccg ccaccgcgcc gaccacggtc agcagattgc
    15241 cggcacgcgg gttgacgtcg atggtctggt cgaactgctg gttgcgcagg tcggcctgac
    15301 cgcggatggt gatgttcgct gcggggcctt cgatcagcac cttgtcggta cgggccatgc
    15361 cctggccgaa ctgcacgctg ccgtcgacct ggttgaacgc gaagcccttg gagaagaagt
    15421 cgcggaaatc gaacatcagg cgccgcggca gctgggtcac gctgagcagg ccgagcacgc
    15481 ggccggcgcc gggctccagc tccagcagct ggccattgcg cgcgtgcaga tcgagccggc
    15541 cctgcagttg ggccagctgg aagtccgagg gaccgccact ccacgaggcc tgcagctgcg
    15601 cctgcccgga gccgccacgc agctggccgc cgtaatcgag gttctgcatc aggccgccca
    15661 ggtcttcact gcgcacctgc gcggtcagct cggtacgggc gccaccggta cggcccagcc
    15721 aacggccgtt gatgtcgatt tcctggtcgg gtgcacggaa gcgcagctcg tcaacattca
    15781 ggccattggc cagcgggcgc gtgcgcagca ccgcctgccc cagcaccacc ttgccgaact
    15841 tcaggtcggc aatgtccagc gcgaacggcg gcagcttggc cgggtccatg tcgttggcac
    15901 cggcctgcac ccgcgccggc gcagcaggcg cgcccgcggc cgccggcagc gactgccagt
    15961 acacccgctc aagctggccg ctgatggtgc cgccctcggc gttgggcacg ctcaggcgac
    16021 ctgccagcga aggtccgtcc aggcgcacgt ccagcgcctg cgcgcccggc tgcagctgca
    16081 ggcgggtctg ctcgaaaacg ccaccgatca gcatcagctt gccgacctgc acatccaccg
    16141 cacgcagcgg catgccgtca tcctcaccgc ctccgcgcgc aaggctgatc cactccagtg
    16201 cgtccagggt cgggctgcga ccgttgacgg cgagcccgct cggcggtggc tcgcgatcga
    16261 catgatcgct gcccagggtg acctgcacgc cggtacggtt gttgtggctt cgcgcagcca
    16321 gcgccaggcg ctggccaaag gccacgtcga tgcgaccggc ccccatcggc agctgtgcgg
    16381 ccaccgtggt cgccagcggt tcgccggccg gcttgtccag cggcgcaggc aggtccaggc
    16441 gggtccccac cagatccgaa ctcagccgca gttcgctggg cggcgcaggc gcgcccggtg
    16501 caaccttggg caggttgacc gcgatggtcc acggcgaggt tcctgcgatg tagggtttga
    16561 gccatgccat ttcaggcgcg cggtcgatca gcacgcccgc atcaaggttg gccgacagca
    16621 gcgattcaaa cgccagcttg ctgtcgcgca cgtagctgcc ggcacgcagg ctcagccgac
    16681 cgtcctggcc aaggtgacgc accgccagtt cctcggcatc gaaaccgccg ttgccgtaac
    16741 gggcctgccc atgcatgttg tcgaaggtca gctggaagcg cttgtcgacc agtttcactc
    16801 cgttgaggtc gaccgtaccc tgcaggtggc cctcgccttc atccaggtgc agcggctgca
    16861 gcaggtcgaa ggtcacatgc gccggtcccg cagcggtgag gttgtcgagc gtgtcgccat
    16921 agtccttgtg caagggactc tgccgcagca tcgccagcag cttgccggcc tcgctctggg
    16981 cgtcggcacg cacgtacagc ggctgctggc cgaaatccgg aatgcccgcc tcgaacgtct
    17041 gtaccgccac gccggccagg tcgccgcgcc catgcatgtc gaagccgggg ccgatgaagg
    17101 cgatgtcggc gtcgacctgg ctcatcaggg gccagtcgtg ctggaaacgg atgtcgccgt
    17161 tggtgatgtg gccggtggcc tcgaagcggc catcgttgtt gtcgaacggc cagtcgtcca
    17221 ggtcaccgct gaccaggccg acgccgttgc gcacctggcc accggccagt gccatgtcga
    17281 gccagtcggt ggcgcccttg ctcatcctgg aatggatcca gaagcgcttg gccgcggtca
    17341 tcggcacgtc gtccagcttg gccgccagct gcagccatgg ccgggtgccg tcgccctgga
    17401 accagacacc accgcgcacg tcggcggcat agtcggtgcc ttccacgcgc atcgccgcgg
    17461 tgccgatgcg ccagccgccc gcttcgtcgc gccagcccac cacctgtccc gccaggtgca
    17521 ggtcatggcg cacgccgaat ccggttggcc agtcaaactg cagctgctgg cgcggctgca
    17581 gctgcaggct gaaaccatcg gcatcgccct cgaagcgccc gccgaggcca cgcaggcccg
    17641 gcgagtggcc cacgctggca aagcccagcg atttcagttc accctgcgcc cacagcgggc
    17701 catcacgctg gccggacagc tgcagctcac gtacatccag ttgcggccgg gacaggaaca
    17761 accagtggcg caggccgggg tcgaggcgat cactcagcgc cagcgcgcgc agcgcggtgc
    17821 cggcctgcac atcgccggaa ctcacccgca gctgcctgcc gacctgcagc tgcagaccgt
    17881 cgagttgctg ttcgccgtct tcggtcttca ggcgcaggcg cggcacctgc aaggcccagc
    17941 cgtcggcctg gcgctgccag cgcaggcgtg cctgcaggcg ctgcagctgc aactgcggca
    18001 ctgccacgtc gggcatcggt gcgccatcga tgcgtacctc gcgcaggtcc gaatcggtgg
    18061 tcagcgcaac cggggcgaaa tcacgcaggg tcagccacag gttgagctcg cccttgcctt
    18121 cgcgcaggcg gacgccgccg gcggccagca gcggcgacca cgcatggaaa tcaactggat
    18181 cggcgcccag ccaggcctgg ccgttgccgc gcacgcggtc cacgtccagc accgcggtca
    18241 gtggcagtgc gtcggcctgc gcccaggcgc gcacacccac gcgcaggcgg tcgccattga
    18301 cgcgcaggcg cagatcgatg cgcggcagcg tggtatcgat gcccagatcc ggtgcatgca
    18361 cgcccaggcg gccctcgatc acctgcagtt cgcccagtcg gcgcagcgca tccagcgggt
    18421 caccgccact ggttgactgc ggcaggccgc gcaccgacca gcggccgtcc tcaccctgct
    18481 gcaggtccag cgccaggcca cgcaggcgca actcggtcag cgaacggccc ggcagcagcc
    18541 cgctgtacat cgacaccagc acttccgcct cgccgatcgc caggccctgg ccggcgccga
    18601 tgcgcaggcc cttcagctgc agcaacggac cacgacgggt ccacgcggtc tgcagctggt
    18661 cgaaacgtac tggctggccg gcccgctcac tcagccaggc agcaaccctg tcgggatgac
    18721 gctcggccag cggcagcagc tggctgatgc tgcccaccag caacgcaagc ccgaccaggc
    18781 ccaccgcaca cgcggcaatg aaatgacggc ggatccttcg cagtcgcagg cgcggcggcg
    18841 cgctcatcgg ccgccgccgg cctgcggccg gcgaggatca gagcagaacg acatcgaatt
    18901 gctcctgcag gtactgctcg tccgcctgga agcggatgct cttgccgagg aactcctcca
    18961 gctcggccac cgccgaggat tcctcgtcgg tgatgcgcgc gaccaccttg gtcgaagcga
    19021 tcaccagcag gcgcgcggca tcgaactggc gcaccgcgcg ggtgatctcg cggaagatct
    19081 cgtaggtcac cgtttcggtg gtcttgatgc tgccccggcc actgcactgc gggcaggttt
    19141 ccgacagctg gcgttccagg ctttccaccg tgcgcttgcg ggtcatctcc accaacccca
    19201 gcggcgagaa gtcgtacacc gtggtcttgg catggtcgcg ggccagcgcc ttctccagcg
    19261 tgcgcagcac ctgccggcga tgctcggcat catccatgtc gatgaaatcg atgatgatga
    19321 tgccgcccag gttgcgcagc cgcagctgcc gtgccaccgc ctgcgcggcc tccaggttgg
    19381 tgcggaacac cgtctcttcc aggttgcgct ggccgaggaa cgaaccggtg ttgacgtcga
    19441 tggtggtcat cgcctcggtc tggtcgatca ccaggtaacc accggatttc agcggcacct
    19501 gcttgtccag cgcgcggccg atctcatcct ccaccccgaa catgtcgaag atcgggcggt
    19561 caccggaata cagctccagc ttttcggcca gcaccggcat gtacttggca acgaaggcct
    19621 gcagctggcc gaaggtctcc ttcgagtcca ccttcacctt gtccacgtcc ttgcggatca
    19681 ggtcgcgtac cgaacgcagc ggcaggctca ggtcttcata gatgatgctg caggaggcgg
    19741 cttcgcggcc gcggcgctcg accacgttcc acacccgcga caggtaggcg atgtcctcgg
    19801 cgatggcctc ggccggctgg ccttccgcat tggtgcgcac gatgtagccg tagccgccat
    19861 gctgggccga cagctcggtc accagcgcct tcaggcgtgc acgctcggtc tcgtcttcga
    19921 tgcgggccga cacgcccact accttggact gcggcagcag caccatgtag cgcgagggaa
    19981 tgctgatctg cgtggtcagg cgcgcgccct tggtgccgat cggatccttc accacctgca
    20041 ccacgatgtc ctggccgtcg cgcagcagtt cgacgatcgg cacgctggcc ggcggcggca
    20101 gggtggtgtt ctcggtatcg gcgctggcca ccggggccgg gcgcaccacg tcattggcgt
    20161 gcaggaacgc ggcgcgctcc agcccgacct cgacgaaggc ggcctgcatg cccggcatga
    20221 cccgctgcac cttgcccttg tagatgttgc cgaccacacc ccggcgccag ccgcgctcga
    20281 tgtgcagttc ctgcagcatg ccgttttcga tcaccgcgac ccgggtctcg cgcggggtca
    20341 cattgaccag gatttcctca gacatctgca gcctccctgg cggcatcggc aatgggggcc
    20401 ggcacgccgc agcgcgccag caaacgatcg gtgtgcagca acggcagccc catcacgccg
    20461 gagtagctgc cggacaggtg ctcgatccag cgttcggcgc cgccctggat ggcataggca
    20521 ccggccttgt ccaacggttc gccggtagcc acgtaggcgg cgatgtcggt ggcgtcgatc
    20581 gccgcgaacg tcacctcgga aacaaccagc tcgctgtcca gcccctgcgc gccgaccacc
    20641 accacggcgg tcatcacctg gtgggtgcgc ccggccagcc gcgccagcat cgcccgcgca
    20701 tcggcggcat cgaccggctt gccgaacact tcaccgtcca gcaccacttc ggtgtccgaa
    20761 ccgagcaccc gcgcctgcgg atcatcggcc agcacccggg ccagcccggc gcgcgccttg
    20821 tcggcggcga cccggcagac atactgttcg gcactttcag ccgcagcgcg ctgctcgac
//
