LOCUS       NZ_SNXZ01000004        11917 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Labedaea rhizosphaerae strain DSM 45361 Ga0310470_104, whole genome
            shotgun sequence.
ACCESSION   NZ_SNXZ01000004
VERSION     NZ_SNXZ01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Labedaea rhizosphaerae
  ORGANISM  Labedaea rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Labedaea.
REFERENCE   1  (bases 1 to 770598)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 770598)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004362825.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 13:11:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,753
            Genes (coding)                    :: 7,690
            CDSs (with protein)               :: 7,690
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 11 of 63
            Pseudo Genes (incomplete)         :: 55 of 63
            Pseudo Genes (internal stop)      :: 3 of 63
            Pseudo Genes (multiple problems)  :: 6 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:41:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 755640
            Orig. end                         :: 767557
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SNXZ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11917
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11917
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11917
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6917](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6917)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            210..1046
                     /locus_tag="EV186_RS26560"
                     /old_locus_tag="EV186_104781"
     CDS             210..1046
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (35-119). E-value:
                     1.1e-11. Score: 36.8. Matches aSDomain:
                     nrpspksdomains_EV186_RS26560_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="EV186_RS26560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104781"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_208115786.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.5e-14, bitscore:
                     50.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.6e-09, bitscore: 33.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTMINGATIGWTDTGDGDVTLLLHAGVFEAWFKPLADRLDGRV
                     IRMARAGYAGGVVPSGIVDMAGHAAHAAALLELLGAGPATVVGHSSSSAIALQLAQDRP
                     ELVSRLVLCEPPLIDALVDPADLAEVRAAIGPAIGKAMHAMGSGDLPAAFDAFMSAVCG
                     PGYRAVLIDALGPDGLAQAERDAGFFFTNEMPAVNGWTPVDLASITAPTLFVQGGASPQ
                     ATHRMIARLAATRPDAHVATLDGANHLLPLTHAAELKTLLGSWETTAAPDRSLAKS"
     aSDomain        315..566
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV186_RS26560_Abhydrolase_1.1"
                     /evalue="1.10E-11"
                     /label="EV186_RS26560_Abhydrolase_1.1"
                     /locus_tag="EV186_RS26560"
                     /protein_end="119"
                     /protein_start="35"
                     /score="36.8"
                     /tool="antismash"
                     /translation="PLADRLDGRVIRMARAGYAGGVVPSGIVDMAGHAAHAAALLELLG
                     AGPATVVGHSSSSAIALQLAQDRPELVSRLVLCEPPLID"
     gene            complement(1123..1512)
                     /locus_tag="EV186_RS26565"
                     /old_locus_tag="EV186_104782"
     CDS             complement(1123..1512)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS26565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104782"
                     /product="hypothetical protein"
                     /protein_id="WP_208115787.1"
                     /transl_table=11
                     /translation="MAAEEIEWGGQREGATDAELAFATTLNELLPGLDYWLYADDDGTP
                     WLLVSLDIIDDNAVLDTLRLDFDERGIRGGWSPACLNWDSEMRAEAAGIDVSGPDGLVR
                     QTIDSPVEDLARRAAEWFIAPKNGR"
     gene            1674..1916
                     /locus_tag="EV186_RS26570"
                     /old_locus_tag="EV186_104783"
     CDS             1674..1916
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS26570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104783"
                     /product="hypothetical protein"
                     /protein_id="WP_133852096.1"
                     /transl_table=11
                     /translation="MRRVVVVLAASVLSLAGGLPAASATTNDGRMNHEFVTLYYTNSSH
                     TGSPVGRYYYGWCPDFFTSRTGTTTQYSVTTSYEC"
     gene            complement(2237..2770)
                     /locus_tag="EV186_RS26575"
                     /old_locus_tag="EV186_104784"
     CDS             complement(2237..2770)
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020904.4"
                     /locus_tag="EV186_RS26575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104784"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_133852097.1"
                     /transl_table=11
                     /translation="MSLFDWRAEIVKGVIVHQRLAELDTAGLWSYHLPELAASEDEIEA
                     TESALGHRLDPQFREFLRYANGWRSFYQDVDIFGTRALLGEGAMGSVREMLAAVDPELF
                     FEDVGLAIDDILPVAASDKQTDIFLMSTQESQERGVVIWFAGYTIDRFDSFNEFYLSML
                     DYNRRQIFKFEGRE"
     gene            complement(3115..3639)
                     /locus_tag="EV186_RS26580"
                     /old_locus_tag="EV186_104785"
     CDS             complement(3115..3639)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018984.4"
                     /locus_tag="EV186_RS26580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104785"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_133852098.1"
                     /transl_table=11
                     /translation="MDYEAYAEGAVELVNLDLDSVATVQALVRRRGWERLQARPRDLAE
                     LRKAQDRLAVVVDRSAAGDAAAVVREVNALLLAHPIRPQVAGHDARNWHLHVHDGGTVA
                     ETLIGEAIFGLAFLITELGADRLGRCEAPGCDRAYLDTSSNRSRRYCGTRCATRVNVAA
                     HRRRQAAQSKP"
     gene            3742..4926
                     /locus_tag="EV186_RS26585"
                     /old_locus_tag="EV186_104786"
     CDS             3742..4926
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="EV186_RS26585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104786"
                     /product="MFS transporter"
                     /protein_id="WP_243754299.1"
                     /transl_table=11
                     /translation="MGISAVGNGLWLAAGVLFLNRSAGLPAVQVGLGLTLAGLAGVFAG
                     IPLGVWADAIGPRRVAITMLLLEGAATAAYALVHSFALFLVVAMAAAIGLAGGNAARGA
                     LLAGLFDTAGATKARATMRSVTNLGISLGTLAAGVVLGIDSRAGYLVMLAADALSFVVA
                     AALCALLPETEPHPTHARGPRWRAARDARYIVLAALNGVMTINYAVLTVALPLWVVTAT
                     NAPPWVVAPLFAINTVLCVLLQMRVSSGLDEPGKAATAMRWAGVWFACATILFALAAYR
                     GPITAAILLAAAVVIHTFGELLQAGSSFGLSFALAAPHAHGEYQGVWHVGVGLGESIAP
                     LLLTTTVIGGGLLGWLGLGLLFALTGLATPRLTAWALADRGASPRPGQGFAARE"
     gene            complement(5001..6917)
                     /locus_tag="EV186_RS26590"
                     /old_locus_tag="EV186_104787"
     CDS             complement(5001..6917)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="EV186_RS26590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104787"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_166659335.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.1e-182, bitscore:
                     604.1, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.8e-13, bitscore: 45.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKTLPLLQVSPKAPEPLGPPARSLRVALVNMPWARVDAPSIQC
                     GLLASIVRNAGHHCTVHYLNVELAAVVGPKTYNGIADAGGERLHQFGEWLFSYAAFGEL
                     RPDSEYHAEFPDVEEIWRDVTGEGIDTISTLRRETLPRWLAEWADAVDWSGYDIIGFSS
                     TFLQNTASLALGRILKDKFPEVALLYGGANFDGEMGAEYLRKLPWIDHVVTGEGDHALP
                     ALLHRLAAGEPLTGVPGVWTRGATGPATESTRTQDLDTLPVPDYTEYFAAIERHGAQAV
                     VGDEPVKLLVEFARGCWWGQKHHCTFCGLNALGMGFRPKTGERAMHELEQMLRAHPVTH
                     VEAVDNILDMKHLSTLCASLAEKHWDVSTFYEVKANLTREQLAVLAAAGINRIQPGIES
                     LSTHVLNLMRKGSTKLINVRLLKWARYHDIKPEWNILSGFPGETDADYAEQAALVPLLY
                     HLRPPDCGGILWLERFSPYFTDETFGITNVRPRACYRFVYPETLDHSKIAYYFDYEAPG
                     IASQPARKSLYAAVGEWRRKWREEVPPSLTYRRLPTSLTITDRRLDTESTTTYTGWQAD
                     VYEACGDTARAAKRLHQDILDQGHNLTLDDVTAFLDDCCANGMMLTEDDKYLALAIPEN
                     RHW"
     gene            6982..8343
                     /locus_tag="EV186_RS26595"
                     /old_locus_tag="EV186_104788"
     CDS             6982..8343
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS26595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104788"
                     /product="hypothetical protein"
                     /protein_id="WP_133852101.1"
                     /transl_table=11
                     /translation="MNATEDFTRRCAAGDTELLHAMATAAGYLPPVFREFREEGLLPRP
                     LFVPRAAVTDFADGLRALFDLLVELPRRVFDGDLERYCKAAGMDADRARQVHRFADRAP
                     TLFGRADAYRVGGRFRLLELNVCSAVGGIDSAHIPPALLRVPAFRAFAEAHGLGFTDSG
                     RMLADALRAAAAAGDPTVAFVCPDGEWPGHQGHLESYAEVLAGFGLRAVTGEISAVRDR
                     GGRLELGGERVDVIVRFLSDAELIAASGPGSAGETILRAHEEGRVVLWTGLENQRVNNK
                     GALALLADDAVREALTGAEARLVDDVLPWTRRLADTETTVGGEPVGLLEHCRAERESLL
                     LKPSFGHGGRGLVIGWQTDDATWARCLADGVRDAWIVQERVLPDPEPVVDPATGVVVPW
                     SPVWGVFLTPAGYAGLHVRAVPADSPDPVIRRMAAGARTTSAFHYPARHDELAS"
     gene            complement(8310..9242)
                     /locus_tag="EV186_RS26600"
                     /old_locus_tag="EV186_104789"
     CDS             complement(8310..9242)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS26600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104789"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_133852102.1"
                     /transl_table=11
                     /translation="MKIKEYLGFRVAKCDVDEALTGAWRDRAGEIDIVRVSAPPVTAWP
                     RLRRAGFVCKPKLIRWYAEVDGYRERLSRKDRWNLRNAERLAEQAGLRGEVVSPIDAAF
                     MDEFLELYKERIAEMRRGLDVAGGIRDSVIADDSYRAVVARHPDGSLAGAVIGRPFAGD
                     GAFRVNVSAVTPHWRKASLTRTLYARAAELAREHGLPRVSAGTDPNVFGLIAEPGLYSF
                     KSRLGFRPTAPEELLPDEAEHEADLVLRLDQLSDPALIVGYAESGDGLVLHVFSHDPDL
                     DLRHYTAGLAHAPVLHHLPQEASSSCRAG"
     gene            complement(9239..10534)
                     /locus_tag="EV186_RS26605"
                     /old_locus_tag="EV186_104790"
     CDS             complement(9239..10534)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="EV186_RS26605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104790"
                     /product="MFS transporter"
                     /protein_id="WP_133852103.1"
                     /transl_table=11
                     /translation="MPTSLATRALGPAGPARTLVQAQLITALGNGLFLSSFALYTIRVV
                     GLSPAQLGLVLSVAAVAALFAGVPFGHLADQYGARGVTAGLHVLAGLLTLVVLLPRSFW
                     LFLVAVCVYMVIYRGSNAAKAGLTVTVLKGDVLVVARARIQAVNNFGLSVGAAIGAVVL
                     TLNTPTAFISGMIFNAASFIGCGLMMTRLPAVPRTTPRAAGEPRLRVLRDYPYATVAFI
                     NAIMLAHSPLLEVILPLWVVLHTDAPRGLVAILVVVNTVAVVLMQVRVTKGVDTLARAV
                     RAFRISGLILGAACIAYAASSANGVLVAILLLVVATLLHVYGEMIHSAGSWVVAFELAP
                     AERQGQYQGLFSTGLSMIQIIGPALLTLLLINGGVIGWGVLAAVFILAGLAMGPAARWA
                     ERTRPTATATPEPEARPDAKAPAEATIAEEPA"
     gene            complement(10554..10964)
                     /locus_tag="EV186_RS26610"
                     /old_locus_tag="EV186_104791"
     CDS             complement(10554..10964)
                     /EC_number="1.20.4.4"
                     /GO_function="GO:0030612 - arsenate reductase (thioredoxin)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005440252.1"
                     /locus_tag="EV186_RS26610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104791"
                     /product="arsenate reductase ArsC"
                     /protein_id="WP_133852104.1"
                     /transl_table=11
                     /translation="MASAPGVLFVCVHNAGRSQMAAAFLRAHGGDRVVVRSAGSAPADV
                     VNPAVVEVMRERGLDLTGEVPKKLTEDAVREADVVITMGCGDACPVFPETRYIDWKLDD
                     PAGKGPDEIRPIRDEIERRVRALVDELTATPV"
ORIGIN
        1 cgctcgcgcc gaggcgatgt ccggtttcga cgccctggct ctgctggtcc cgacccgcga
       61 gggcgtccag gcatggaaga cggccctgga tgagctgggc gagccgcacg gcggcgtcgt
      121 gaccggccac aacggcggct ccgtcctggt cggtctgcac gaccccgacg gcatcgagat
      181 caggctctac tccgagtgaa ggaagcccca tgaacaccac gatgatcaat ggcgccacca
      241 tcggctggac ggacaccggg gacggcgacg tcaccctgct cctgcacgcc ggtgtcttcg
      301 aagcctggtt caagccgttg gcggaccgcc tcgacggccg ggtgatccgg atggcgcgcg
      361 ccggctacgc cggtggcgtc gtgccgtccg gcatcgtcga catggccggg cacgcggcgc
      421 atgccgccgc cctgctcgag ctgctggggg ccggccccgc caccgtcgtc ggtcactcgt
      481 ccagctcggc gatcgcgctg cagctcgcgc aggacagacc ggagctcgtg tcccggctcg
      541 tgctctgcga accgccgctg atcgacgcgc tggtcgatcc ggccgacctc gccgaggtgc
      601 gggccgcgat cgggcccgcg atcggcaaag ccatgcacgc catgggaagc ggcgacctcc
      661 ccgccgcgtt cgacgccttc atgtccgccg tctgcggccc cggctaccgc gcggtgctca
      721 tcgacgcact cggcccggac gggctcgccc aagccgagcg cgatgccggc ttcttcttca
      781 ccaacgagat gccggccgtc aacggctgga cgcccgtcga cctggcgtcg atcaccgcac
      841 cgaccctctt cgtccaaggc ggcgcaagtc cacaggcgac ccaccggatg atcgcgcgcc
      901 tcgccgccac cagacccgac gcccacgtcg caaccctcga cggcgccaac cacctgctcc
      961 cgctcaccca cgccgccgag ctgaaaaccc ttctcggctc gtgggaaacc accgcagcac
     1021 cagatcgatc tttggcgaag tcttagcagt tgccggagaa cctgagcatc aaccgccact
     1081 ccgtgcgaga gcacgggctc gctgacagcg ccgagcagta actcatcgtc cgttcttggg
     1141 tgcgatgaac cactccgcgg cacgcctggc gagatcctcg acgggcgaat cgatcgtctg
     1201 gcggacgagg ccatcgggtc ccgatacatc gatcccggcc gcctccgccc gcatctcact
     1261 gtcccagttg aggcaggccg ggctccaccc accgcgaatg ccacgctcat caaagtccaa
     1321 gcgcagggtg tcgagcacgg cgttgtcgtc gatgatgtcc aaggagacaa gaagccacgg
     1381 agtgccatcg tcatctgcgt acagccagta atccaaacca ggaagcagct cattcagcgt
     1441 cgtcgcgaag gcgagttcag catcggtcgc accctcgcgc tgtccacccc actcgatctc
     1501 ttccgcagcc acgtctcgga gcctcctctc gaaaattcct tcggaccggc ccgcaatcgc
     1561 tgccatgagg cccttcacgg cccgggtcgt ccgttcgggt gcggcctgac cggcggatgt
     1621 tcagcgggag ccgattccgg gaagatcctg gtacgccgat cgaaggaggc gcgatgcgcc
     1681 gcgttgtcgt tgtgctggcc gccagtgttc tgtcgttggc cggtgggcta cctgccgcgt
     1741 cggccactac caacgacggg cggatgaacc acgagttcgt cacgctctac tacaccaatt
     1801 catcgcacac cggcagcccg gtcgggcgct actactacgg ctggtgccca gacttcttca
     1861 cctcccggac cggcacaacc acccagtact cggtgaccac gagctacgag tgctgaatgc
     1921 tcgccatgcc ctgatcaacc gggtgcgacc cccgacgacg gtccagccca accagcgtcg
     1981 ccggcaccag taggactccg acggcgaccc ggtcggtagc cctctgcggt ttgacggcgt
     2041 cagtcatcac cttcatccgg atcgcgccga tgagcccgcc gactacccgc agtacaccga
     2101 ccgcgggtcg tgcccttgat cgcgactacc acgtctggtg gagccatcgc gcgaatgccg
     2161 gacggcacag ccctgccaac acgaaacctg aaagtcacgg cgtccgctaa ccgtgtgcga
     2221 gaaatcgacg gttgacttat tcacggccct cgaacttgaa tatctgccga cgattgtagt
     2281 cgagcatgga caggtagaac tcattgaagc tgtcgaatcg gtcgattgta tatccggcaa
     2341 accaaatgac gacaccccgt tcctgcgatt cctgcgtact catcaaaaag atgtccgtct
     2401 gcttgtcgct ggcggcgacg ggcaggatgt catcaatcgc caagccgaca tcctcgaaga
     2461 acaattccgg gtcgaccgca gcaagcatct ccctgacgct gcccatcgcg ccctcgccca
     2521 gcaaggccct tgtcccgaag atgtcgacat cctgataaaa ggaacgccaa ccgttggcgt
     2581 accgcagaaa ctcacgaaac tgcgggtcca accggtggcc aagagcgctc tccgttgcct
     2641 cgatctcgtc ctcgctcgcg gcaagttcgg gaaggtggta gctccacaag ccggcagtgt
     2701 ccagttcggc gagtcgctga tgcacgatga cgcctttgac gatctcggct cgccagtcga
     2761 acaggctcat ggttccttcc gaagcgcttg atgtagtcgt cgatgtacca gaaaccccgt
     2821 cggccgataa ccggtcgcgt aacgccgcgc ttgcgaaccg cggctctcgc gagcatgccc
     2881 gactgaatcg ccgtggagca caccgtgcta acccgaatct accgggaaag ctgcgttgga
     2941 ccggcgtggc acgaaagcgc cgatcgactt gtcgcgttcc gacatcgcct gatcacgcac
     3001 ctcagcgaac ccggcattct ctcggtccac gacagggccg ccccgccagc ggcacgagaa
     3061 ggcaggccgg cgcggactga aaacagtgaa ggtcaccgcg aaaccgctgg tctgctacgg
     3121 cttggactgc gctgcttgac gacggcggtg cgccgcgacg ttgacgcggg tggcgcaccg
     3181 ggtgccacag tagcggcggg accggttgga cgacgtgtcg aggtaggcgc ggtcgcagcc
     3241 gggtgcctcg caccggccga gccggtcggc gcccagttcg gtgatcagga acgccagccc
     3301 gaagatcgcc tcgccgatga gggtttccgc caccgtgccg ccgtcgtgca cgtgcaggtg
     3361 ccagttccgg gcgtcatgcc cggcgacttg ggggcggatc gggtgtgcga ggagcagtgc
     3421 gttgacctct cggaccacgg cggccgcgtc gcccgcggcc gagcggtcca cgaccaccgc
     3481 gagccggtcc tgggccttcc gcagctccgc caggtcacgg gggcgcgcct gcagccgctc
     3541 ccagccgcgc cgccgcacca gcgcctggac ggtggcaacc gagtccaggt ccaggttgac
     3601 cagctcgacc gcaccctcgg cgtaagcctc gtagtccact tgtgcagctt accggccagt
     3661 cgttagcgta atagtcagag ctcatcactg actattacgg gggtcggctt gtcacgagca
     3721 cttcgcctgt tactcgtggc catgggcatc agcgcggtcg gcaacgggct ctggctcgcc
     3781 gccggcgtgc tgttcctcaa ccggtccgcg ggcctgcccg ccgtgcaggt cggtctcggc
     3841 ttgaccttgg cgggcttggc cggcgtcttc gcgggcatcc cgctcggtgt gtgggccgac
     3901 gccatcgggc cgcgccgcgt cgcgatcacc atgctgctgc tggaaggcgc ggccacggcc
     3961 gcctacgcgc tggtgcattc cttcgcgctg ttcctcgtgg tcgcgatggc tgccgcgatc
     4021 gggctggccg gcggcaacgc cgcccgcggc gccctgctcg ccggcctgtt cgacaccgca
     4081 ggcgcgacca aggctcgagc cacgatgcga tcggtcacca acctgggcat ctcgctgggc
     4141 acgctggccg ccggagtcgt gctcggcatc gactcccgcg ccggttacct cgtcatgctc
     4201 gccgccgacg ccctcagctt cgtcgtcgcc gcggccctgt gcgccctgct ccccgagacc
     4261 gaaccgcacc ccacgcacgc gcgcggaccg cgctggcgcg ccgcgcgtga cgcccggtac
     4321 atcgttctcg ccgccctcaa cggcgtgatg accatcaact acgcggtgct caccgtcgcg
     4381 ctgccgctgt gggtcgtcac cgccaccaac gcaccgccgt gggtcgtcgc tcccctcttc
     4441 gcgatcaaca ccgtcctttg tgttctgttg cagatgcggg tcagcagcgg actggacgag
     4501 cctggcaaag cagccacggc gatgcggtgg gcgggcgtgt ggttcgcctg cgccacaata
     4561 cttttcgcac tcgcggcgta ccgcggcccg atcacggcgg ccatcctgct cgccgccgcc
     4621 gtggtgatcc acaccttcgg cgaactgctg caggccggca gttcgttcgg cctgagcttc
     4681 gccctcgccg caccgcacgc ccacggcgag taccagggcg tgtggcacgt cggcgtcggt
     4741 ctcggcgaga gcatcgcccc gctcctgctg acgaccacgg tcatcggcgg cggcctgctc
     4801 ggctggctcg gcctcggtct gctcttcgcc ctcaccggcc tcgccacccc acgcctgacg
     4861 gcctgggccc tagctgaccg gggcgcgagc ccaaggcctg gtcaaggctt cgcagcgcgc
     4921 gagtgacgtt gcgaacgccg atccgacttg tggacctgac aggccctatc gcaaacccga
     4981 cctcgccaac cgccgtcagc tcaccagtgc cggttctccg ggatcgccag ggccagatac
     5041 ttgtcgtcct cggtgagcat catgccgttg gcgcagcagt cgtccaggaa tgccgttacg
     5101 tcgtcgaggg tgaggttgtg gccttggtcg aggatgtcct ggtggaggcg tttggcggcg
     5161 cgggcggtgt cgccgcaggc ttcgtagacg tcggcttgcc atcccgtgta agtggttgtg
     5221 ctttccgtgt cgaggcggcg gtcggtgatc gtgagactgg tgggcaggcg gcggtaggtg
     5281 aggctgggcg gcacttcctc acgccatttg cggcgccatt cgcccacggc ggcgtagagg
     5341 ctcttgcggg ccggttggga agcgattcct ggtgcctcgt agtcgaagta gtaggcgatc
     5401 ttgctgtggt cgagggtttc ggggtagacg aatcggtagc acgcgcgggg ccggacgttg
     5461 gtgatgccga acgtctcgtc ggtgaagtag gggctgaacc gctcgagcca gaggatgccg
     5521 ccgcagtccg ggggacgcag gtggtacagc agcggtacga gcgcggcctg ctcggcgtag
     5581 tcggcgtcgg tctcgccggg gaaaccgctg aggatgttcc actccggctt gatgtcgtgg
     5641 tagcgggccc atttgagcag ccggacgttg atcagtttcg tggagccctt gcgcatcagg
     5701 ttgagcacgt gggtgctcag gctctcgatg ccgggctgga tgcggttgat gcctgcggcg
     5761 gcgagcacgg ccagctgctc acgggtgagg ttggccttga cctcgtagaa tgtgctgacg
     5821 tcccaatgct tttccgcgag cgaagcgcac aatgtggaca ggtgcttcat gtcgaggatg
     5881 ttgtccacgg cctcgacgtg ggtgacgggg tgcgcgcgca gcatctgctc cagctcgtgc
     5941 atggcgcgtt cgccggtctt gggccggaaa cccatgccga gggcgttgag gccgcagaag
     6001 gtgcagtggt gcttctgacc ccaccagcag ccgcgggcga actcgaccag cagtttgacc
     6061 ggttcgtcgc cgacgacggc ttgcgcgcca tggcgttcga tggccgcgaa gtactcggtg
     6121 tagtcgggca cgggcagggt gtcgaggtcc tgggtgcggg tggactcggt ggccggtccg
     6181 gtcgcgccgc gggtccagac gccggggacg ccggtcagcg gttcacccgc ggcgaggcgg
     6241 tgcagcagcg cgggcaacgc gtggtcgcct tcgccggtca cgacgtggtc gatccacggc
     6301 agcttgcgca ggtactcggc gcccatctcg ccgtcgaagt tcgcgccgcc gtagagcagg
     6361 gcgacttccg ggaacttgtc cttgaggatg cggccgagcg ccagggaggc ggtgttctgc
     6421 aggaacgtgg acgagaaccc gatgatgtcg tagcccgacc agtcgaccgc gtcggcccat
     6481 tcggccagcc agcgtggcag ggtttcccgg cgcagggtgc tgatggtgtc gatgccctcg
     6541 ccggtgacgt cgcgccagat ctcttccacg tcggggaact cggcgtggta ctcgctgtcg
     6601 gggcgcagtt cgccgaacgc cgcgtaggag aacagccatt cgccgaactg gtgcagccgc
     6661 tccccgcccg cgtcggcgat gccgttgtag gtcttgggtc ccaccaccgc ggcgagttcg
     6721 acgttgaggt agtgcacggt gcagtggtgc ccggcgttgc gcacgatgga cgcgagcagt
     6781 ccacattgga tggatggggc gtccacccgg gcccagggca tgttcaccag ggccacccgc
     6841 aacgaacgcg ccggcgggcc cagcggctcc ggcgccttcg gcgacacctg gaggagggga
     6901 agggttttct cggtcatgcc ggtcctccta ggagcgattg gggcttggct ttcgttgcgg
     6961 gacaaggcga tactggcggc gatgaacgcc accgaggact tcacgcgccg ctgcgccgcg
     7021 ggtgacacgg agttgctgca cgccatggcc acggcggccg ggtacttgcc gccggtcttc
     7081 cgggagttcc gggaagaggg cttgctcccc cggccgctgt tcgtgccgcg ggccgcggtc
     7141 acggacttcg ccgacgggtt gcgcgccttg ttcgacttgc tggtcgagtt gccgcgccgg
     7201 gtgttcgacg gcgacctcga gcgctactgc aaggccgcgg gcatggacgc ggaccgggcc
     7261 cggcaggtgc accggttcgc cgaccgggcg ccgacgttgt tcggtcgcgc ggatgcctac
     7321 cgggtgggcg gccggttccg gttgctggag ttgaacgtgt gcagcgcggt cggcggcatc
     7381 gactcggcgc acatcccgcc ggcgttgctg cgggtcccgg cgttccgggc gttcgccgaa
     7441 gcgcacgggc tgggcttcac cgacagcggg cgcatgctgg ccgacgccct gcgggccgcg
     7501 gccgcggcgg gcgacccgac cgtcgctttc gtgtgcccgg acggcgaatg gcccggccac
     7561 caaggacacc tggagtccta tgcggaggtg ctggccgggt tcgggttgcg cgcggtgacc
     7621 ggcgagatct cggccgtgcg ggaccgcggt ggccggctgg aactcggcgg cgagcgcgtc
     7681 gacgtgatcg tgcggttcct cagcgacgcc gagctgatcg cggcgtcggg gccgggcagc
     7741 gcgggcgaaa ccatcctgcg ggcccatgaa gagggtcgtg tcgtgttgtg gaccgggctg
     7801 gagaaccagc gggtcaacaa caagggcgcc cttgccctgc tggccgacga cgcggtccgc
     7861 gaagcgctga ccggcgccga ggcccggctg gtcgacgacg tgctgccctg gacaaggcgg
     7921 ctcgccgaca ccgagacgac ggtcgggggt gagccggtcg ggctgctgga gcactgccgt
     7981 gcggagcggg agtcgttgct gctcaagcca tccttcgggc acggcggccg cggcctggtg
     8041 atcggctggc agaccgacga cgccacctgg gcgcggtgcc tggccgacgg cgtgcgtgac
     8101 gcgtggatcg tgcaggaacg cgtgctcccc gatcccgaac ccgtggtcga cccggccacc
     8161 ggtgtcgtgg tcccgtggtc gccggtctgg ggcgtgttcc tgaccccggc cgggtacgcc
     8221 gggctgcacg tgcgtgccgt acccgccgac tcgccggacc cggtgatccg ccggatggcc
     8281 gcgggcgccc gcaccaccag cgcgttccac tacccggccc ggcacgacga gctcgcttcc
     8341 tgaggcaggt ggtgcagcac gggcgcgtgc gcgaggccgg ccgtgtagtg gcggaggtcg
     8401 aggtccgggt cgtggctgaa gacgtgcagc accaagccgt cgccggactc ggcgtagccg
     8461 acgatcaggg ccgggtcgct gagctggtcc agccgcagca cgaggtcggc ttcgtgttcg
     8521 gcctcgtcgg gcaggagctc ttcgggcgcg gtgggccgga acccgaggcg ggacttgaag
     8581 ctgtagagcc ccggctcggc gatcagcccg aagacgttgg gatcggtgcc ggcggacacg
     8641 cgcggcaacc cgtgctcacg cgcgagctcg gcggcgcggg cgtagagcgt ccgggtgaga
     8701 ctggccttgc gccagtgcgg ggtgaccgcg gagacgttga cccggaacgc accatcgcct
     8761 gcgaaggggc gcccgatcac cgcgcccgcg aggctgccgt ccgggtggcg ggcgacgacg
     8821 gcgcggtagc tgtcgtcggc gatcacggag tcgcggatgc cgccggcgac gtcgaggccg
     8881 cggcgcatct cggcgatgcg ttccttgtac agctcgagga actcgtccat gaacgcggcg
     8941 tcgatcgggg acacgacctc gccgcgcaga ccggcttgct cggccaggcg ttcggcgttg
     9001 cgcaggttcc accggtcctt gcgcgacaac cgctcacggt agccgtcgac ctccgcgtac
     9061 cagcggatca acttgggttt gcacacgaac ccggctcgcc gaagccgcgg ccacgccgtg
     9121 accggcggcg ccgacacgcg cacgatgtcg atctcgccgg cccggtcgcg ccaagcgccg
     9181 gtcagcgcct cgtcgacgtc acacttggcg acccggaaac ccaggtactc cttgatcttc
     9241 atgcgggctc ttcggcgatg gtcgcctcgg ccggcgcctt ggcgtccgga cgagcctcgg
     9301 gttccggcgt cgccgtcgcg gtgggccggg ttcgttcggc ccagcgcgcg gccggtccca
     9361 tcgccaggcc ggcgaggatg aacacggcgg ccaggacgcc ccagccgatc acgcctccgt
     9421 tgatcagcag caacgtcagc agcgcgggac cgatgatctg gatcatcgac aggccggtgc
     9481 tgaacaggcc ctggtactgg ccctgccgct cggcgggcgc gagctcgaac gcgacgaccc
     9541 acgaacccgc ggagtggatc atctcgccgt acacgtgcag cagggtggcc accaccagca
     9601 gcaggatcgc gaccaggacg ccgttggccg acgacgcggc gtaggcgatg caggcggcgc
     9661 cgaggatcag cccggagatc cggaacgcgc gcaccgcgcg ggccagcgtg tcgacgccct
     9721 tggtcacccg gacctgcatc agcacgacgg cgacggtgtt gaccacgacg aggatcgcga
     9781 cgagaccgcg gggcgcgtcg gtgtgcagga ccacccacag cgggaggatg acctccagca
     9841 acggcgagtg cgccagcatg atcgcgttga tgaacgcgac cgtcgcgtac gggtagtcac
     9901 gcagcacgcg cagcctcggc tcccccgccg cgcgcggggt cgtgcgcggc acggcgggca
     9961 gccgggtcat catcagcccg cacccgatga agctggcggc gttgaagatc atcccgctga
    10021 tgaaggcggt cggcgtgttc agcgtcaaca cgacggcgcc gatcgcggca ccgacggaca
    10081 ggccgaagtt gttcaccgcc tggatgcgag cgcgcgcgac gacgagcacg tcgcccttga
    10141 ggacggtgac cgtcagcccg gccttggccg cgttgctgcc gcggtagatg accatgtaga
    10201 cgcacaccgc gaccaggaag agccagaacg agcgcggcag cagcaccacc agcgtcagca
    10261 gcccggccag cacgtgcaga ccggcggtga cgccgcgggc gccgtactgg tcggcgaggt
    10321 gcccgaacgg cacgccggcg aacagcgccg cgaccgcggc cacgctgagc acgaggccca
    10381 gttgcgccgg ggacaacccc acgacccgga tggtgtagag cgcgaacgaa ctgaggaaca
    10441 acccgttgcc cagcgcggtg atcagctggg cttggaccag cgtccgggcc ggcccggcgg
    10501 ggccgagggc gcgggtcgcg agggatgtcg gcacgcagag cctccagggg ttctcagacc
    10561 ggggtcgcgg tcagttcgtc gacgagcgcg cgcacgcgcc gttcgatctc gtcacggatc
    10621 ggccggatct cgtccgggcc cttgcccgcg gggtcatcga gcttccagtc gatgtagcgg
    10681 gtctccggaa acaccgggca tgcgtcgccg caccccatcg tgatcaccac atcggcctcg
    10741 cgcaccgcgt cctcggtgag cttcttgggt acttcaccgg tcaagtcgag gccgcgctcg
    10801 cgcatcacct cgaccaccgc cgggttcacg acgtcggcgg gcgccgaacc cgcggagcgc
    10861 accaccacgc ggtcaccgcc gtgcgcgcgc aggaacgccg ccgccatctg ggagcggccc
    10921 gcgttgtgca cgcagacgaa cagcacaccg ggcgccgagg ccatggctct ccttccccag
    10981 tgacggctcc atcgatgcta gtcgatgagc gccttctatc gaagtcaacc gatacagagg
    11041 aatcaatccg accacggacg caggcgctat cggccgttcg ggtgaactgc gggtggaccg
    11101 ggaaaccgtt gaccaccagc gtttatcggt ccattgacat gtatcgctga agcgtgtcag
    11161 ggtgaccgct gcgcggtcca gtccaattca acttggggga cgcaatgtcc gatgcccgtg
    11221 cgctcgtcgt ctcggctttc gaggcggaac tccaaccgtt gacgtgtgcg tgcgcggccg
    11281 ccgcgctgcg cgatcagggt gccgacgtga ccggttggga cgctcacgcg ttccccgacg
    11341 cgatgccgga cggaccgttc gacctcgtgc tgttgtcggt gcagcagttc gaaggcgtcg
    11401 agcgcggact cgccctcgcc gaacggcttt cggccgccta cggcacgacg ctggtggcgt
    11461 tcggtcagta cgcgcagatg aaccaccgcc ggttcctgga gaccgtcgac gcggtgctga
    11521 tggaggaacc ggagctcgtc gccgccgaac tggccgacgt ggcacgcagg acccgcgccg
    11581 catccgaggt gccggccgcc atcacccggc acggcatgcg accgagaccg ccccaccggc
    11641 ggatcaaagt ccctgtgccc gcaagggaat tgttcccctc gatggtgcac tacccggcgc
    11701 accacacccc gtacggcctg atgggcaacg tggaggcgac ccgcggctgc caccacaagt
    11761 gcacctactg ctcggtgtac ggcgcctacg acggcggggt cgcggcctac gacgcggaca
    11821 ccgtgctggc cgactgcctg caactggccg acgaaggcgt gcggcacttc tgcttcatcg
    11881 acgcggagtt cttcaactcc cgcaccatcg gcgcgaa
//
