LOCUS       NZ_SNXZ01000004        20966 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Labedaea rhizosphaerae strain DSM 45361 Ga0310470_104, whole genome
            shotgun sequence.
ACCESSION   NZ_SNXZ01000004
VERSION     NZ_SNXZ01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Labedaea rhizosphaerae
  ORGANISM  Labedaea rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Labedaea.
REFERENCE   1  (bases 1 to 770598)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 770598)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004362825.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 13:11:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,753
            Genes (coding)                    :: 7,690
            CDSs (with protein)               :: 7,690
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 11 of 63
            Pseudo Genes (incomplete)         :: 55 of 63
            Pseudo Genes (internal stop)      :: 3 of 63
            Pseudo Genes (multiple problems)  :: 6 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:41:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 241430
            Orig. end                         :: 262396
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SNXZ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20966
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="nucleoside"
                     /region_number="2"
                     /rules="(LipM or LipV or LipU or TunD or pur6 or pur10 or
                     nikJ or nikO or truD)"
                     /tool="antismash"
     cand_cluster    1..20966
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /kind="single"
                     /product="nucleoside"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20966
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10966](+)"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10966
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
     gene            610..1323
                     /locus_tag="EV186_RS23975"
                     /old_locus_tag="EV186_104262"
     CDS             610..1323
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034814.1"
                     /locus_tag="EV186_RS23975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104262"
                     /product="sirohydrochlorin chelatase"
                     /protein_id="WP_208115771.1"
                     /transl_table=11
                     /translation="MSLVLVAHGSRDPRSAATIAALADVVRAARPGLDVRVAFLDLSAP
                     RVGDVLAGLSRAVIVPLLLGRAFHADVDLPNLVHEAVARNPRLSVAVSSVLGPDPLLRR
                     AAVRRLRESGVSLDDPSLGIVVAAAGSSRRSSTDAVHALARSWPRARAAFASAGSPTVD
                     DAVAALRSAGARRLAVASWFLAPGRLPDRIEAAIHAIDPSAIIAEPLGPAPEVAELVLR
                     RHDEAATEEATARYA"
     gene            complement(1743..2321)
                     /locus_tag="EV186_RS23980"
                     /old_locus_tag="EV186_104263"
     CDS             complement(1743..2321)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS23980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104263"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_133851650.1"
                     /transl_table=11
                     /translation="MEPAMVIEAARTTRNALAGAPRDAWSGEVPHLDWTVRETVAHAIK
                     SAYFCGIDLAAGDLRMRAPSVVVDAEAPVDHLLDGLLGAARLTSHVVRAAAPHALGYDP
                     DGPADASGFAAMCCAELLIHGWDAATGLAVPLTADARLASAVLARLFPELVPQGDPWSE
                     LLWACGRIALPGKGKRVNWTWWVRPLDEH"
     misc_feature    2355..2370
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 30.57"
                     /tool="antismash"
     misc_feature    complement(2355..2371)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 28.06"
                     /tool="antismash"
     gene            2382..2840
                     /locus_tag="EV186_RS23985"
                     /old_locus_tag="EV186_104264"
     CDS             2382..2840
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073768.1"
                     /locus_tag="EV186_RS23985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104264"
                     /product="DUF4396 domain-containing protein"
                     /protein_id="WP_133851651.1"
                     /transl_table=11
                     /translation="MTEHQHHDSSWRTAITATLHCLTGCAIGEVLGMVIGTAFGWGNAA
                     TVVLSIALAFLFGYSLTMRPILRAGVALGVAIPIAFAADTVSIAVMEVIDNAFVLVIPG
                     AMDAGLASALFWGSLAASLVLAFVVTVPVNRWMIGRGKGHAVVHRYHH"
     gene            2916..4571
                     /locus_tag="EV186_RS23990"
                     /old_locus_tag="EV186_104265"
     CDS             2916..4571
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334280.1"
                     /locus_tag="EV186_RS23990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104265"
                     /product="type VII secretion target"
                     /protein_id="WP_133851652.1"
                     /transl_table=11
                     /translation="MPDPMVLYRKLTSGDEAGITAVRKALTQVRASLRAAADGITEGAT
                     TAATHWRGDARTEFLTDVSATVTDTAEVYRRLRTVDRVLAGAATAYGDLHRSADSAIRP
                     WRAAGNADPALALSVQRNLLAARYTYESRLGTLATHLDPGSSDWTDLTHVGPGQPWIPQ
                     GLAYRADRDQLLVTSYNESKDADSQSRLTLVDNATGEEQKHVDLGGLEYSGPAGQPATG
                     APPNHAGGVATHGDNVWVTSTVVNDDGTQTSQVYVYSQKAIDRAQPGATVHPTQVINVP
                     ASSYITYADGKLWIGQYATDGDPKLYSFNTGKDGSIKGVTPTGEPDPYAGGDVPGEYPT
                     PQHVQGVVVRDDQFVFSQSDGESGSSFITQDRDYRGFDLLDPDTWDARDEYRLGDNADG
                     DPIHGVEEIEEIDGEIVTVHESGADKYDDDGHDHHDDITRTPLTELGLDSGDGYQTDPD
                     ALTEAAGQLDGSAEKLQNAADVTGGLQLVAHVLGDVPAAGPFSAAVTRYLADRGQELGT
                     GAQSLRDTADGLIAGADTYRRLEDFLTAGFGGTN"
     gene            4582..5355
                     /locus_tag="EV186_RS23995"
                     /old_locus_tag="EV186_104266"
     CDS             4582..5355
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (6-248). E-value: 7.2e-54. Score:
                     174.6. Matches aSDomain:
                     nrpspksdomains_EV186_RS23995_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034812.1"
                     /locus_tag="EV186_RS23995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104266"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_133851653.1"
                     /transl_table=11
                     /translation="MADELVHYEVSKGIATITLDSPHNRNALSAQLRRELKAHLTAAAA
                     DDAARVIVLTHTGTVFCAGMDLKEAGTAGSESQGVQEFPQILEQLWTSPKPVVARLSGP
                     ARAGGVGMVAAADIAVAAENATFAFTEVRIGVVPAVISVTVLPRLLPRAAHELFLTGET
                     FDGKRAAQVGLINSAVPAEQLDAEVRRYTDLLVLGAPGALAATKQMLRREKAATMADDF
                     ADMLELSAKHFAGEEGQEGIASFVQKRKANWVPEA"
     aSDomain        4600..5325
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV186_RS23995_ECH.1"
                     /evalue="7.20E-54"
                     /label="EV186_RS23995_ECH.1"
                     /locus_tag="EV186_RS23995"
                     /protein_end="248"
                     /protein_start="6"
                     /score="174.6"
                     /tool="antismash"
                     /translation="HYEVSKGIATITLDSPHNRNALSAQLRRELKAHLTAAAADDAARV
                     IVLTHTGTVFCAGMDLKEAGTAGSESQGVQEFPQILEQLWTSPKPVVARLSGPARAGGV
                     GMVAAADIAVAAENATFAFTEVRIGVVPAVISVTVLPRLLPRAAHELFLTGETFDGKRA
                     AQVGLINSAVPAEQLDAEVRRYTDLLVLGAPGALAATKQMLRREKAATMADDFADMLEL
                     SAKHFAGEEGQEGIASFVQK"
     gene            complement(5364..6491)
                     /locus_tag="EV186_RS24000"
                     /old_locus_tag="EV186_104267"
     CDS             complement(5364..6491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034906.1"
                     /locus_tag="EV186_RS24000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104267"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_133851654.1"
                     /transl_table=11
                     /translation="MSHDIRAFLPADCDLLGIGEPTHQEPGFGRIRNELFAQLTELGFR
                     SVAMETDRVAALVVDEFVRDGVGTLDTVMSEGFSHEFGALEPNRELVSWMHEYNMDRPP
                     ADRLAFHGFDAAMETMSAPSPRAYLEHARDYLGLDLDIASLAGDDEQWSRVEAVMDPAM
                     SPGATAEADQLRVLADDLLLALYTRAPELIAITSRARWLAAKAHLTAGLGLLRYHKQCA
                     QPLELNARIAKLSNCRDALMAQNLLELRQLESGRGPTLVSAHNSHLQRSPSAWRDDNID
                     FGWLGAGATIGALLGQRYTVVAGSLGCSAAIGLAEPPPHTYEASLQDRVTDWALIPTDE
                     VAPAEKRTDTNPRQGYFPLDKTILDGIDVVLHLRG"
     misc_feature    6552..6570
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.82"
                     /tool="antismash"
     misc_feature    complement(6566..6580)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            6574..7281
                     /locus_tag="EV186_RS24005"
                     /old_locus_tag="EV186_104268"
     CDS             6574..7281
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943431.1"
                     /locus_tag="EV186_RS24005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104268"
                     /product="TioE family transcriptional regulator"
                     /protein_id="WP_133851655.1"
                     /transl_table=11
                     /translation="MSTLRPADLAREHGISTQAVRNYERDGFLPPAARSASGYRTYTDV
                     HAAALRAFLALIPAYGHAGAGRIMLAANEGQLDQALLLIDRAHAQLLRDRETLATVRKA
                     VGPLTSEAAELAAPASTRTIGELARWLGVTPATVRNWERAGILVPDRHKGTGYRVYQPS
                     DLRDAELTRLLRRGGYPLDHIRTVVEQVRTAGGTEALAGALDDWQQRLTTQGLAMLDAA
                     ARLGEYLRLRGVG"
     gene            complement(7282..7710)
                     /locus_tag="EV186_RS24010"
                     /old_locus_tag="EV186_104269"
     CDS             complement(7282..7710)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013677875.1"
                     /locus_tag="EV186_RS24010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104269"
                     /product="VOC family protein"
                     /protein_id="WP_133851656.1"
                     /transl_table=11
                     /translation="MEQNVHFITVATDDLDAVRAFYVDGLGWESRLDVPGNIIFFQVAP
                     GVMLGLFDSATFREDLGGAVTDTSITGLTLSYNVDGPDAVDRVIEEAAAAGARVVKKPQ
                     RAAFGGYHGHFADPNGLVWEVCHNPGWRIDADGTVTVN"
     misc_feature    7695..7709
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.32"
                     /tool="antismash"
     gene            complement(7761..8414)
                     /locus_tag="EV186_RS24015"
                     /old_locus_tag="EV186_104270"
     CDS             complement(7761..8414)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020495352.1"
                     /locus_tag="EV186_RS24015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104270"
                     /product="DUF899 family protein"
                     /protein_id="WP_133851657.1"
                     /transl_table=11
                     /translation="MNRPEVVTPQQWQAAREELLVKEKELTHALDALAAERCRLPMVQL
                     STDHRFVAPDRTEVSLTDLFDGRRQLVIYHFMQSPDQDWVCAGCASFTDNLAGDQTHLN
                     QRDTRFILMARAPQDELDVLLKRFGWTHPWYTAGQGFYDEMGLDDLFALTVLLRDGDEV
                     FRTYATTRRGVDRLRTDFNLLDLTPYGRQEQWEDSPEGWPQTETMAWIQLRDEY"
     gene            8471..8926
                     /locus_tag="EV186_RS24020"
                     /old_locus_tag="EV186_104271"
     CDS             8471..8926
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983017.1"
                     /locus_tag="EV186_RS24020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104271"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_133851658.1"
                     /transl_table=11
                     /translation="MQRTHFGEMACSIARTLDVIGEPWSPLILRDVYVGITRFDQLQQE
                     LGISRKVLAERLKWLVGQEVLERKQYTDRPPRFEYALTAKGRELCDLLLVMVRWGDRFT
                     AGEAGPPVLYRHHACGEISHVELRCSVCGERMNATDVDVLPGPGQRA"
     gene            complement(8923..9258)
                     /locus_tag="EV186_RS24025"
                     /old_locus_tag="EV186_104272"
     CDS             complement(8923..9258)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013500.4"
                     /locus_tag="EV186_RS24025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104272"
                     /product="barstar family protein"
                     /protein_id="WP_133851659.1"
                     /transl_table=11
                     /translation="MQQADTTEEALATYPDATPHLIDGPGSKAKFMTAIAAALSFPDWF
                     GRNLDALQDCVRDLSWLEPGEHLLVWRNPGALRGGDAATFHHVEDILTQADGRTAGAVT
                     LHVVAVD"
     gene            complement(9258..9668)
                     /locus_tag="EV186_RS24030"
                     /old_locus_tag="EV186_104273"
     CDS             complement(9258..9668)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004521 - RNA endonuclease activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947693.1"
                     /locus_tag="EV186_RS24030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104273"
                     /product="ribonuclease domain-containing protein"
                     /protein_id="WP_133851660.1"
                     /transl_table=11
                     /translation="MGSRKRITLALVGLVVLVVVGWLVKENTGDSSPPSSSSPSSSGMQ
                     VKPLSQLPPEVGDTWRLIVKGGPYPYREDGQTFQNREGLLPHEKTGYYREYTVDTPGSD
                     DRGAQRLIYGSGKELYYTADHYKSFVVVDPEH"
     gene            complement(9678..9932)
                     /locus_tag="EV186_RS24035"
                     /old_locus_tag="EV186_104274"
     CDS             complement(9678..9932)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS24035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104274"
                     /product="hypothetical protein"
                     /protein_id="WP_133851661.1"
                     /transl_table=11
                     /translation="MQWLSDWWNDIELWMTQQSFWLQFALVIVVVGPLCVGVAWLIDRL
                     VDKAAARFGPARRAGHKLQALPEPERRPEPGDQPAGTAS"
     gene            10001..10966
                     /locus_tag="EV186_RS24040"
                     /old_locus_tag="EV186_104275"
     CDS             10001..10966
                     /NRPS_PKS="Domain: PKS_ER (17-319). E-value: 6.3e-30.
                     Score: 96.3. Matches aSDomain:
                     nrpspksdomains_EV186_RS24040_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: LipV"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005454992.1"
                     /locus_tag="EV186_RS24040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104275"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_133851662.1"
                     /sec_met_domain="LipV (E-value: 3.7e-114, bitscore: 376.6,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 2.6e-06, bitscore: 22.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.8e-19, bitscore:
                     63.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAVYATEPKPDDPLAALAVGERPDPQAPEGWVAVNVRAASLNMH
                     DLWTLRGVGIKADQFPMILGCDGAGVLEDGTEVVLHSVIGDPAWRGDETLDPKRTLLTE
                     KHQGTFADTVVVPARNALPKPSSLSFAEAACMGTAWLTAYRMLFTKSGLRPGQTMLVQG
                     ASGGVSTALIELGRAAGMRVWVTGRTEAKRSLALDLGAHETFESGARLPERVDAVFETV
                     GKATWSHTMKSLKPGGIVVISGATSGDATAAELQRLFFLQLRVVGSTMGTREELGDLLR
                     FCDQAGIRPKIGSELPMTEAAQGMRAMLDGETNGKIVFTR"
     aSDomain        10052..10957
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV186_RS24040_PKS_ER.1"
                     /evalue="6.30E-30"
                     /label="EV186_RS24040_PKS_ER.1"
                     /locus_tag="EV186_RS24040"
                     /protein_end="319"
                     /protein_start="17"
                     /score="96.3"
                     /tool="antismash"
                     /translation="LAVGERPDPQAPEGWVAVNVRAASLNMHDLWTLRGVGIKADQFPM
                     ILGCDGAGVLEDGTEVVLHSVIGDPAWRGDETLDPKRTLLTEKHQGTFADTVVVPARNA
                     LPKPSSLSFAEAACMGTAWLTAYRMLFTKSGLRPGQTMLVQGASGGVSTALIELGRAAG
                     MRVWVTGRTEAKRSLALDLGAHETFESGARLPERVDAVFETVGKATWSHTMKSLKPGGI
                     VVISGATSGDATAAELQRLFFLQLRVVGSTMGTREELGDLLRFCDQAGIRPKIGSELPM
                     TEAAQGMRAMLDGETNGKIVF"
     CDS_motif       10466..10525
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EV186_RS24040_0001"
                     /evalue="2.10E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="EV186_RS24040"
                     /protein_end="175"
                     /protein_start="155"
                     /score="14.0"
                     /tool="antismash"
                     /translation="GQTMLVQGASGGVSTALIEL"
     gene            <10978..>11088
                     /locus_tag="EV186_RS40165"
                     /pseudo=""
     CDS             10978..>11088
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005465179.1"
                     /locus_tag="EV186_RS40165"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DUF2945 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTVELKITSEATGRKVRTSPDEPQYLVRSDKSGRTAV"
     gene            complement(11087..12139)
                     /locus_tag="EV186_RS24050"
                     /old_locus_tag="EV186_104276"
     CDS             complement(11087..12139)
                     /GO_function="GO:0018580 - nitronate monooxygenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015785635.1"
                     /locus_tag="EV186_RS24050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104276"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_133851663.1"
                     /transl_table=11
                     /translation="MFAQLRVPVIAAPMAGGPSTPELVAAACDAGGFGYLAAGYLTPDA
                     VRAQLAATRELTTQPFGLNLFTPGQRSTVDLSRYQAVVAAEAARYDTTEGRPGWDDDHY
                     AAKLDLAVAERVAAVSFTFGAPLPDDVARLRDAGIHVTVTVTTPAEAARAAATGADALC
                     VQGMSAGGHRGVFEDDPWLPGGGDLFGTLDALRLVAAEVDLPLVAAGGLIRGADVAAVL
                     AAGAVAAQLGTAFLRCPEAGTSKVHRTELAEGARPTALTRAFSGRPARGLLNRFMTEHE
                     QQAPAAYPQLHHLTKPVRAAAAAAGDPEAVSMWAGTTYRQAVEAPVAEVMATLVAEARE
                     ALATATKRLA"
     gene            12193..12630
                     /locus_tag="EV186_RS24055"
                     /old_locus_tag="EV186_104277"
     CDS             12193..12630
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098896.1"
                     /locus_tag="EV186_RS24055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104277"
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_133851664.1"
                     /transl_table=11
                     /translation="MPFMVEDAIAIATKAHRGQRDKSGHAYIGHPLRVMGMMRTDHERM
                     TAVLHDVVEDTEVTADDLRAAGCPDAVVEAVIAISKRPGEDHEDYLARVAANPMALAVK
                     RADIADNSSPERMDELDGPTRSRLRAKYEKATRLLDTYSRA"
     gene            complement(12615..13142)
                     /locus_tag="EV186_RS24060"
                     /old_locus_tag="EV186_104278"
     CDS             complement(12615..13142)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098893.1"
                     /locus_tag="EV186_RS24060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104278"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_279538319.1"
                     /transl_table=11
                     /translation="MFTVDDLATMPDDGRRYELIDGMLVVSPLPGFRHQKAVMKLLVAL
                     EMSCPDDVEVLVGPFAVRPSPTLELRPDGLAARRSDLTEDCLPVAPLLAVEVLSHSSAI
                     NDLNNKKAVYERLGVPSYWVVDPGPPSLVAFDLVDGAYRLTTEVQEDEVFEATQPFPVR
                     IVLAELLGQARE"
     gene            complement(13214..13585)
                     /locus_tag="EV186_RS24065"
                     /old_locus_tag="EV186_104279"
     CDS             complement(13214..13585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670005.1"
                     /locus_tag="EV186_RS24065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104279"
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_133851665.1"
                     /transl_table=11
                     /translation="MASPPLDRLRALCLALPEATEKLSHGSPTWFVKKVFVMYVDDHHG
                     DGITGFWCAAPPGVQEELVAEEPDRFFRPPYVGHRGWLGVRLDGEVDWAEIGEIVVDAY
                     RCVAPKKLVAELESRRSSG"
     gene            complement(13600..13899)
                     /locus_tag="EV186_RS24070"
                     /old_locus_tag="EV186_104280"
     CDS             complement(13600..13899)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS24070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_104280"
                     /product="hypothetical protein"
                     /protein_id="WP_133851666.1"
                     /transl_table=11
                     /translation="MTPSRTREGVLPGVAAVVVVELLVAGLFAVGVHPFGWMDADFAVV
                     MGVVLAVAFVLGAALSLAGKPLGRGLLVGVAVCLVLGLVAIVVFWIVFAKTFTF"
     gene            complement(13904..15748)
                     /gene="lepA"
                     /locus_tag="EV186_RS24075"
                     /old_locus_tag="EV186_104281"
     CDS             complement(13904..15748)
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420815.1"
                     /locus_tag="EV186_RS24075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104281"
                     /product="translation elongation factor 4"
                     /protein_id="WP_133851667.1"
                     /transl_table=11
                     /translation="MSTFADTTFTAPEQIRNFCIIAHIDHGKSTLADRMLQITGVVQAR
                     DMRAQYLDRMDIERERGITIKAQNVRLPWTLDGAQHVLHMIDTPGHVDFTYEVSRALDA
                     CEGAILLVDAAQGIEAQTLANLYMALDRDLHIIPVLNKIDLPAADPEKYAAEIAHILGG
                     EPEDVLRVSAKTGMGVSELLDEVVRQVPPPVGVADAPARAMIFDSVYDTYRGVVTYIRV
                     VDGKITPRERIRMMSTGAVHELLEVGIISPEPKPSQGLGVGEVGYLITGVKDVRQSRVG
                     DTVTSERKGATEALSGYREPQPMVYSGLYPVDGSDYPDLREALDKLQLNDAALTYEPET
                     SAALGFGFRCGFLGLLHLEITRDRLEREFGLDLISTAPNVVYRVVLDDRGELTVTNPSD
                     WPEGKVAEIFEPVTKCTIIAPSEYIGTIMELCQGKRGQLGGMDYLSEDRVELRYTMPLG
                     EIIFDFFDSLKSRTRGYASLDYEESGEQASDLVKVDILLQGEPVDAFSAIVHKDAAYGY
                     GTRMATRLRELIPRQQFEVPIQAAIGSRIIARETIRAMRKDVLAKCYGGDITRKRKLLE
                     KQKEGKKRMKMVGRVEVPQEAFVAALSTDEPTGKDKKK"
     gene            complement(15818..16660)
                     /locus_tag="EV186_RS24080"
                     /old_locus_tag="EV186_104282"
     CDS             complement(15818..16660)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058032.1"
                     /locus_tag="EV186_RS24080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104282"
                     /product="transglutaminase family protein"
                     /protein_id="WP_133852140.1"
                     /transl_table=11
                     /translation="MSWRVRVVHTTGYRYEAPVVQSYNEARLTPRSDRRQNLVVARLET
                     TPATRSYRYTDYWGTEVTSFDLHAPHTELKIVASSVVETTEHVQPIDDASWADLRGDGI
                     ADRYGELLEPTRYAPRNKELISIARKLRTGRRPMEAVLAVSEWVHDQLTYHQGTTGVHS
                     SAIDAWQAREGVCQDYAHLTLAMLRSIGIPARYVSGYLHTKPDGAIGETVRGESHAWIE
                     AWTGGWWGFDPTNDIEIGQRHVWVAIGRDYGDVSPLKGTYSGGAASAIEVSVDMTRLA"
     misc_feature    16708..16724
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.5"
                     /tool="antismash"
     gene            complement(16711..17658)
                     /locus_tag="EV186_RS24085"
                     /old_locus_tag="EV186_104283"
     CDS             complement(16711..17658)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669228.1"
                     /locus_tag="EV186_RS24085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104283"
                     /product="alpha-E domain-containing protein"
                     /protein_id="WP_133851668.1"
                     /transl_table=11
                     /translation="MLARNAESLYWIGRYVERADDTARILDVSVHQLLEDATVDADATS
                     RQLLTVLGITPPPGMELDVWTLTELVAMSREHAGSIVSSISSARENTRVAREVVSTELW
                     ECINSMYNAVPERQRAAKRVGPSLFFSFVEERAAMFAGLADSTMSRDDGWRFLVLGRFV
                     ERVDMIVRLLMSRVGDKPSSPGWVTVLRSAGAHDTYLRTYRGALDATRVVQFLLLDRLF
                     PRSVFHALSQAESCLDHLDNQPSTRVGAKAEASRLLGKARSELEFLRPEELLEDLTGRL
                     LGLQQCIRDVGEAVALQYFHSVPWVAWTNAEVSL"
     gene            complement(17669..19252)
                     /locus_tag="EV186_RS24090"
                     /old_locus_tag="EV186_104284"
     CDS             complement(17669..19252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669229.1"
                     /locus_tag="EV186_RS24090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104284"
                     /product="circularly permuted type 2 ATP-grasp protein"
                     /protein_id="WP_133851669.1"
                     /transl_table=11
                     /translation="MNRASGNGDLFDNYLDPKRPHAGAFDEMFAADSTVRSAYRRLYDS
                     LSPSKPADLATRAEALDRALVDQGITFSLSGQERPFPLDLIPRVITAGEWAKLERGIVQ
                     RVRGLEAFLADIYGDQQIIRDGVLPRRLITSCAHFHRQAAGVSPPNGVRIHVSGVDLVR
                     DEDGTFRVLEDNLRSPSGVSYVMENRRTMARVFPDLFAKHRVRAVGDYAVHLLRALRAA
                     AAPNVADPTVVVLTPGVHNSAYFEHSLLARLMGVELVEGRDLFCRDNVIYLRTTEGERQ
                     VDVIYRRIDDEYLDPVQFRPDSVLGVAGVINAARAGNVVIANAVGNGVGDDKLVYTYLP
                     EILKYYLDEAPLLPNVDTYRCWLREERQYVFDHADELVIKPVEGSGGYGIVFGPDASAK
                     ELAAIRRRVRANPRGWIAQPLVQLSTVPTKVGQRLKPRHVDLRPFAVNDGKSVFVLPGG
                     LTRVAVPEGSLVVNSSQGGGSKDTWVLAARSSTVDPELSGQRLGTPQEESAPERGPELT
                     SAQQQQQQQQ"
     gene            complement(19298..20914)
                     /locus_tag="EV186_RS24095"
                     /old_locus_tag="EV186_104285"
     CDS             complement(19298..20914)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023643.4"
                     /locus_tag="EV186_RS24095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_104285"
                     /product="peptide-N4-asparagine amidase"
                     /protein_id="WP_166659302.1"
                     /transl_table=11
                     /translation="MRRLLIATAAFLLLGATQATADTVVTDYQDPLQALPSVSRPATDS
                     CTVTAMHHVFANSYGQPYVGTLTPPSSCAGDWTKVVLDWTASSAGRQYDRLAGIWIGGA
                     EVARTSTPEPDPTGITWHFDKDITEFSPLLHQAQPFVVDLGNIVNDTYTGPYDVTVTIT
                     YFKADRHHPAPRQADKVLPLAADHNSPGWQALGDGQTYNAQVTVPGNTAKLTAEIYARG
                     GGCEEFWWSNVPTSVSQGNPDAGLCGGGTYREVDVAVDGHPAGAVMPYPTIYTGGVAPM
                     LWRPISAIDAIVTLPYTIDLSPFIGTLTDGKAHTITLTPPKGIVDVWTLGGNLFATTDP
                     HTKRVTGELRTADVPEAQVHTDLTGTGIDVTATTTVDRSWHTEGVLHTSQGRITVKAGG
                     QWTFANTTSLTDSAARQQTTHRVDGAYTANGRTDRFGFTLDADSTTAYTDSNNYRIDAT
                     VHMGRVLRTELGHGRLLAFSDDQIDTSGGFGRTNGQLTYADGQSSERWRGLDDTGRCLD
                     RTLVTAHGWVTGDRTVNARCR"
     misc_feature    complement(20928..20943)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
ORIGIN
        1 catctggacc tcggtgcacc gcgccgtgct cggcttcctg atcggcgtgg cgatcgcgac
       61 gccgatcggc ctggtcgtgg ccaaggtgcg cttcgtgcgc gccgcgatcg ggccgttgtt
      121 gtccgggttg cagagcctgc cgtcggtggc gtgggtgccg gccgcggtgc tgtggttcgg
      181 cgtgaccccg acgacgatct acgtggtgct gctgctgggc agcattccgt cgatcgccaa
      241 cggtctcgtg gccgggatcg accagatccc gccgatcctg ccgcgagccg ggaaggtgat
      301 gggcgccggg cgcctggccg gggcgcggca catcctgctg ccggccgcac tgcccggcta
      361 cctggccggg ctcaagcagg gctgggcgtt ctcgtggcgg tcgctgatgg ccgcggagat
      421 catcgccacg tcacccgacc tcggcaccgg cctcggcgcg tacctcgaca acggccggtt
      481 cctcgcggac atgcccaccg tgatctcggc gatcgtgttg atcctcttcg tgggggtggg
      541 gatcgagttg ctggtcttcc gcccgttgga gcgggtcgtg ctggccgcgc gtgggctcgg
      601 cggtgcgctg tgagcttggt attggtggcc cacggcagcc gcgacccccg ctcggccgcg
      661 acgatcgccg cgctcgccga cgtcgtgcgc gccgcgcggc cgggtctcga cgtgcgggtg
      721 gccttcctcg acttgtccgc gccccgcgtc ggcgatgtgc tggccgggct gtcgcgggcc
      781 gtgatcgtgc ctttgttgct gggccgggct ttccacgccg acgtggacct gccgaacctg
      841 gtgcacgagg cggtggcgcg caacccgcgg ctgtcggtgg cggtgtcctc ggtgctggga
      901 ccggatccgc tgcttcggcg ggcggcggtg cgccggttgc gtgagtccgg ggtgtcgctc
      961 gacgacccgt cgctcgggat cgtggtggcg gcggccggct cgtcgcgccg gtcctcgacc
     1021 gacgccgtgc acgcgttggc ccgctcgtgg ccccgcgccc gtgcggcgtt cgcgtcggcc
     1081 ggctcaccca cggtcgacga cgcggtggcc gcgctgcgtt ctgctggggc gcgacgcctc
     1141 gcggtggcgt cgtggttcct ggcgcccggc cgcctcccgg accggatcga ggccgcgatc
     1201 cacgcgatcg atccgtcggc gatcatcgcc gaaccgctgg gcccggcgcc ggaagtcgcc
     1261 gaactggtgc tccggcgcca cgacgaggca gccaccgaag aagccaccgc ccgctacgcc
     1321 tgactcccgc tcccgcctcc ctcacctctc cattcccgcc tgcccgcctc cccgcctgcc
     1381 cgcctccccg cctgcccgcc tcctcgcctg cccgctctcc cctgcccgct ctcccctgcc
     1441 cgcctgccca cctgcccctt cccgcctgcc cgctctcgcc tgcccgcctg cccgctctcg
     1501 cctgcccgcc tgtccactcc cgcctccccg ctcctcttgt gctgcctcgc ccgcgttcac
     1561 catcccgcgt ttggagttat ccacagctgg gcagttgtcc acagatcccg ctatttcccg
     1621 ttgcggggtt ggaaaaccga tagactggct tcggggtcgc cccccggagc gggtgggggc
     1681 acgggtactc aaccacaggg cgacagcgtg ggttttgctt gcgaagcaag gaaagcggcg
     1741 cgctagtgct cgtcgagtgg acgcacccac cacgtccagt tgacgcgctt tcccttgccg
     1801 ggcaaggcaa tccggccaca agcccacaac aactccgacc agggatctcc ctgcggcacg
     1861 agttccggga acaaccgcgc aagcaccgcc gacgccaacc gcgcgtccgc ggtcaggggc
     1921 accgccagac cggtcgccgc gtcccagccg tggatcagca actccgcgca gcacatcgcg
     1981 gcaaatccgc tggcgtccgc cggtccatcc gggtcgtacc ccagcgcgtg cggtgccgcc
     2041 gcccgcacga cgtgtgacgt gagccgtgcg gcgccgagca ggccgtcgag caggtggtcg
     2101 accggagctt cggcgtccac cacgaccgag ggcgcgcgca tcctcaggtc gccggccgcc
     2161 aggtcgatcc cgcagaagta cgccgacttg atggcgtgcg cgaccgtctc gcgcacggtc
     2221 cagtcgaggt gcggcacctc acccgaccac gcgtcccgag gcgcgcccgc cagcgcgttg
     2281 cgcgtcgttc gagcagcctc gatcaccatc gctggctcca cgccacgagc atgaccgaca
     2341 tcacccggca ggaaataccc caggggggta ccctcagcac catgaccgaa caccagcacc
     2401 acgactcctc ctggcggacc gcgatcacgg cgaccttgca ctgcctcacc ggctgcgcca
     2461 tcggcgaggt gctcggcatg gtcatcggga cggccttcgg ctggggcaac gcggccaccg
     2521 tcgtgttgtc gatcgccttg gcgttcctgt tcggctactc gctgaccatg cggccgatcc
     2581 tgcgcgcggg cgtcgccctc ggcgtggcca tcccgatcgc gttcgcggcg gacaccgtgt
     2641 cgatcgccgt catggaggtc atcgacaacg cgttcgtgct ggtcatcccc ggcgcgatgg
     2701 acgcgggcct cgcgtcggcg ctgttctggg gcagccttgc cgcctcgctc gtgctggcct
     2761 tcgtggtgac cgtgccggtg aaccgctgga tgatcggccg cggcaagggt cacgccgtgg
     2821 tgcaccgcta ccaccactga ccacacggga accgaaagcc gccccgcgga ctctgaacag
     2881 aacgcacgtt tcgtccgagt ccgggagcag cgcccatgcc cgatccgatg gtcctctacc
     2941 gcaagctcac ctcgggcgac gaggccggga tcacggcggt ccgcaaggcg ttgacgcagg
     3001 tccgggcgtc cttgcgggcc gccgcggacg ggatcaccga aggggccacc accgccgcga
     3061 cccactggcg gggcgacgcg cgcaccgagt tcctgaccga cgtctcggcg accgtcaccg
     3121 acacggccga ggtctaccgc cggctgcgca cggtcgaccg cgtgctcgcc ggcgccgcaa
     3181 cggcctacgg tgacctgcac cgatccgctg actccgcgat ccggccgtgg cgcgccgcgg
     3241 gcaacgccga cccggccctc gccctcagcg tccagcggaa cctgctggcc gcgcgctaca
     3301 cctacgagag caggctcggc acgctcgcca cccacctcga ccccggcagc agcgactgga
     3361 ccgatctcac gcacgtcggc cccggtcagc cgtggatccc gcaagggctc gcctaccggg
     3421 ccgaccgcga ccagctgctg gtcacctcgt acaacgaatc gaaggacgcc gactcgcaga
     3481 gcaggctcac gctggtcgac aacgcgaccg gcgaggagca gaagcacgtc gacctcggcg
     3541 gcctggagta ctcgggcccg gccggtcagc ccgcgaccgg cgcgccaccc aaccacgcgg
     3601 gcggggtcgc cacccacggc gacaacgtgt gggtgacctc gaccgtggtg aacgacgacg
     3661 gcacgcagac cagccaggtc tacgtgtact cgcagaaggc gatcgaccga gcccagcccg
     3721 gcgcgaccgt gcacccgacg caggtgatca acgtgccggc gagcagctac atcacctacg
     3781 ccgacggcaa gctgtggatc ggtcagtacg ccaccgacgg cgacccgaag ctctacagct
     3841 tcaacaccgg caaggacggt tcgatcaagg gcgtcacgcc caccggcgag cccgacccgt
     3901 acgcgggcgg cgacgtcccc ggcgaatacc cgaccccgca acacgtgcag ggcgtcgtgg
     3961 tgcgcgacga ccagttcgtg ttcagccagt ccgacggcga gagcggcagc tcgttcatca
     4021 cccaggaccg cgactaccgc ggcttcgacc tgctggaccc ggacacctgg gacgcgcggg
     4081 acgagtaccg gctcggcgac aacgccgacg gcgacccgat ccacggcgtc gaggagatcg
     4141 aggagatcga cggcgagatc gtcaccgtgc acgagtccgg ggccgacaag tacgacgacg
     4201 acggccacga ccaccacgac gacatcaccc ggaccccgct gaccgagctc ggcctcgact
     4261 ccggcgacgg ctaccagacc gaccccgacg ccctgaccga ggcggccggg cagctcgacg
     4321 gttcggccga gaagctgcag aacgccgccg acgtgaccgg cgggctccag ctggtcgccc
     4381 acgtgctcgg cgacgtgccg gccgcgggcc cgttcagtgc cgcggtcacc cggtacctgg
     4441 ccgaccgcgg ccaagagctg ggaaccggcg cgcaatcgtt gcgggacacc gcggacggcc
     4501 tcatcgccgg cgccgacacc taccggcgtc tcgaggattt cctcacagcc gggttcggtg
     4561 gcacgaacta aggtgcaccc catggccgac gagctggtgc actacgaggt gtccaaggga
     4621 atcgcgacga tcacgctgga ctcgccgcac aaccgcaacg cgctgtccgc gcagctgcgc
     4681 cgggaactga aggcgcacct gaccgcggcc gccgcggacg acgccgcccg ggtgatcgtg
     4741 ctgacccaca ccgggacggt gttctgcgcg ggcatggacc tcaaggaggc gggcaccgcg
     4801 ggctccgagt cccaaggcgt gcaggagttc ccgcagatcc tcgaacaact gtggaccagc
     4861 cccaaacccg tggtcgcccg cctctcaggg ccggcccgcg ccggcggtgt cggcatggtc
     4921 gcggcggccg acatcgcggt cgccgccgag aacgcgacgt tcgcgttcac cgaggtgcgc
     4981 atcggtgtgg tgcccgcggt gatctcggtg acggtgctgc cccggctgct gcccagggcc
     5041 gcccacgagc tcttcctcac cggcgagacc ttcgacggca agcgcgccgc gcaggtcggt
     5101 ctgatcaact cggcggtgcc cgccgagcag ctcgacgccg aggtcaggcg ctacaccgac
     5161 ctgctggtgc tgggcgcgcc cggcgcgctc gccgcgacca agcagatgct gcgccgggag
     5221 aaggccgcga ccatggccga cgacttcgcc gacatgctcg aactgtccgc caagcacttc
     5281 gccggcgagg aaggccagga gggcatcgcc tcgttcgtgc agaagcgcaa ggcgaactgg
     5341 gtgcccgagg cctagacatt tggctagccc cgcaggtgca ggacgacgtc gatcccgtcc
     5401 aggatcgtct tgtccagcgg gaagtagccc tgccgcgggt tcgtgtcggt gcgtttctcg
     5461 gccggcgcga cctcatcggt cgggatgagc gcccagtcgg tgacgcggtc ctgcagtgac
     5521 gcctcgtagg tgtgcggcgg gggctcggcc agcccgatcg ccgcgctaca cccgaggctg
     5581 cccgcgacca cggtgtaccg ctgccccagc agcgcgccga tcgtcgcgcc cgcgccgagc
     5641 cagccgaagt cgatgttgtc gtcgcgccag gcgctcgggc tgcgttgcag gtggctgttg
     5701 tgcgcggaca ccagggtcgg gccgcggccg gactcgagct gcctgagctc cagcaggttc
     5761 tgcgccatga gcgcgtcgcg gcagttggag agcttggcga tccgggcgtt gagttccagc
     5821 ggctgcgcgc actgcttgtg gtagcgcaac aagcccaggc ccgcggtgag gtgcgccttg
     5881 gcggcgagcc accgggcccg cgacgtgatc gcgatcagct cgggggcgcg cgtgtagagc
     5941 gcgaggagca ggtcgtcggc gagcacgcgc aactggtcgg cctcggccgt cgcgcccggc
     6001 gacatggccg ggtccatgac cgcttcgacc cggctccact gctcgtcgtc cccggcgagg
     6061 ctcgcgatgt cgaggtccag gcccaggtag tcgcgggcgt gttcgaggta ggcgcgcggg
     6121 ctcggcgcgc tcatcgtctc catggccgcg tcgaagccgt ggaaggcgag gcggtccgcg
     6181 ggcggacggt ccatgttgta ctcgtgcatc caggaaacca gctcccggtt gggttccagc
     6241 gcaccgaatt cgtgcgagaa gccctcgctc atcaccgtgt ccagggtgcc cacgccgtcg
     6301 cggacgaact cgtccacgac cagcgccgcc acgcggtcgg tctccatggc gaccgaacgg
     6361 aagccgagct cggtcagctg tgcgaacaac tcgttacgga tccgaccgaa gcccggttcc
     6421 tggtgggtgg gttcgccgat gcccagcagg tcgcagtcgg cgggcaggaa agcgcggatg
     6481 tcgtgactca tgagattcaa gcgtatcgtt gaaagctcgg ttgagacttt gcacaactcg
     6541 accagcgagg acttgagcta gagtctcaaa ccgatgtcca ccctgaggcc agccgacctc
     6601 gcgcgcgagc acggcatctc gacccaggcg gtccgcaact acgagcgtga cgggttcctg
     6661 ccgcccgccg cgcgcagcgc gagtggctac cgcacctaca ccgacgtgca cgcggcggcg
     6721 ctgcgggcgt tcctcgcgct catcccggcc tacggccacg cgggcgcggg ccggatcatg
     6781 ctcgcggcca acgagggtca gctcgaccag gcgctgctgc tcatcgaccg cgcgcacgcc
     6841 cagttgctcc gcgaccggga aacccttgcc acggtgcgga aagcggtcgg cccgctcacc
     6901 tccgaagccg ctgaactcgc ggcgccggcg agcacccgca ccatcggcga gctcgcccgc
     6961 tggctcggcg tcacgccggc gacggtccgc aactgggagc gcgccggcat tctcgtcccg
     7021 gaccgccaca agggaaccgg gtaccgggtt taccagccca gtgacctgcg ggatgcggag
     7081 ctcacgcgcc tgctgcgccg gggcggctac ccgctcgacc acatccgcac ggtcgtcgag
     7141 caggtccgca ccgcgggtgg caccgaggcc ctggccggcg ccttggacga ctggcagcaa
     7201 cggctgacga cgcaggggct ggcgatgctg gacgccgccg cccggctcgg cgagtacctg
     7261 cgcctgcgcg gcgtgggtta gtcagttcac cgtcacggtg ccgtcggcgt cgatgcgcca
     7321 gccggggttg tggcagacct cccagaccag cccgttcggg tcggcgaagt gcccgtggta
     7381 gccgccgaac gccgcgcgct gcggcttctt gaccacccgc gcgcccgcgg cggcggcctc
     7441 ctcgatcacg cgatccaccg catcgggccc gtcgacgttg taggacaacg tcaggccggt
     7501 gatgctcgtg tcggtgaccg cgccgccgag gtcctcgcgg aacgtcgcgc tgtcgaacag
     7561 gccgagcatc acgcccggcg cgacctggaa gaagatgatg ttgccaggaa cgtccagtcg
     7621 cgactcccag cccaggccgt ccacgtagaa ggcccgcacc gcgtcgaggt cgtccgtggc
     7681 gacggtgatg aagtgcacgt tctgttccat gccaccgagt ctgccgccac gacgacgcca
     7741 cggcttgtac gaatcagacg tcagtactcg tccctgagct ggatccacgc catcgtctcg
     7801 gtctgcggcc agccctcggg tgagtcctcc cattgctcct ggcgcccgta cggcgtgagg
     7861 tccagcaggt tgaagtcggt gcgcagccgg tcgacgccgc ggcgggtggt ggcgtaggtg
     7921 cggaacacct cgtcgccgtc gcgcagcagc accgtcaacg cgaagaggtc gtccagcccc
     7981 atctcgtcgt agaacccctg gcccgcggtg taccacgggt gcgtccagcc gaaccgcttg
     8041 agcagcacgt cgagctcgtc ctgtggtgcg cgggccatca ggatgaaccg ggtgtcccgc
     8101 tggttgaggt gcgtctggtc gccggccagg ttgtcggtga aggacgcgca gccggcacag
     8161 acccagtcct gatcgggcga ctgcatgaag tggtagatca ccagctgcct gcgaccgtcg
     8221 aacaagtcgg tcagcgagac ctcggtgcgg tccggcgcga cgaaccggtg atcggtgctc
     8281 agctggacca tcggcagcct gcaccgctcg gcggccagcg cgtccagcgc gtgggtgagt
     8341 tccttctcct tgaccagcaa ctcctcgcgc gcggcctgcc attgctgcgg tgtgacgact
     8401 tccgggcgat tcatgcctgc ccctctcgcg gttagtttct tcaaggaacc atctacgtta
     8461 gcatggcacc gtgcaacgca cccacttcgg cgagatggcc tgctcgatcg cccgcaccct
     8521 cgacgtcatc ggtgagccgt ggtcaccact gatcctgcgc gacgtctacg tcggcatcac
     8581 gcggttcgac cagctgcagc aggagctcgg catctcccgc aaagtgctcg ccgaacggct
     8641 gaagtggctg gtcggccagg aggtgctgga gcgcaagcag tacacggacc ggccgccgcg
     8701 cttcgagtac gcgctgaccg cgaagggccg cgaactctgc gacctgctcc tggtgatggt
     8761 ccgctggggc gaccggttca ccgcgggcga ggccgggccg ccggtgctct accgccacca
     8821 cgcgtgcggc gagatcagcc acgtcgagct gcgctgctcg gtctgcggcg agcggatgaa
     8881 cgccacggac gtcgacgtcc tgcccggccc cggccagcgc gcctagtcca ccgcgacgac
     8941 gtgcagcgtc acggcacccg ccgtcctgcc gtccgcctgg gtgaggatgt cctcgacgtg
     9001 gtggaacgtg gccgcatcgc cgccgcgcaa cgcaccgggg ttgcgccaga ccagcaggtg
     9061 ctcgcccggc tccagccacg acaggtcgcg gacgcagtcc tgcaacgcgt ccaggttgcg
     9121 gccgaaccag tccggaaagg acagtgcggc ggcgatggcg gtcatgaact tcgccttgct
     9181 gcccgggccg tcgatgaggt gcggcgtcgc gtccgggtag gtcgccagcg cttcctcggt
     9241 ggtgtccgcc tgctgcatca atgctccgga tcgacgacga cgaacgactt gtagtggtcc
     9301 gcggtgtagt acaactcctt gccggagccg tagatcagcc gctgcgcgcc gcggtcgtcg
     9361 ctgcccggcg tgtccactgt gtactcccgg tagtaaccgg tcttctcgtg cggcagcagg
     9421 ccttcgcggt tctggaaggt ctgaccgtcc tcccggtacg ggtacgggcc gcccttgacg
     9481 atcaaccgcc aggtgtcgcc gacctccggc gggagctgcg agagcggctt gacctgcatc
     9541 ccggacgacg acggtgaaga tgaagacggc ggcgacgagt cgccggtgtt ctccttcacc
     9601 agccagccga cgacgaccag caccacgagc ccgaccaggg cgagcgtgat gcgcttgcgc
     9661 gaacccaccc cgagagccta cgaagccgtg ccggccggct ggtccccggg ctccggccgc
     9721 cgctcgggct ccggcagtgc ttgcagcttg tgccccgcgc gccgggccgg gccgaaccgg
     9781 gcggccgcct tgtcgacgag ccggtcgatc agccaggcaa cgccgacgca cagcggtccg
     9841 accaccacga tgaccaacgc gaactgcagc cagaacgact gctgcgtcat ccacagctcg
     9901 atgtcgttcc accagtccga cagccattgc acggcctcga ccctacggca tgaccagtgt
     9961 cacggggcgc gaccagggtg agcggactag gttgccagac atgttcgcgg tgtatgcaac
    10021 ggagccgaag cccgacgatc ccctcgccgc actcgccgtc ggcgagcggc cggacccgca
    10081 ggcgcccgaa ggctgggtcg ccgtgaacgt gcgggcggcc agcctcaaca tgcacgacct
    10141 ctggaccctg cggggcgtgg gcatcaaggc cgaccagttc ccgatgatcc tgggctgcga
    10201 cggcgccggc gtgctcgagg acggcaccga ggtggtgctg cactcggtga tcggcgaccc
    10261 ggcctggcgc ggcgacgaga ccctcgaccc caagcggacc ctgctcacgg agaagcacca
    10321 gggcacgttc gcggacaccg tcgtggtgcc cgcgcgcaac gcgttgccga agccgtcgag
    10381 cctgtcgttc gccgaggccg cctgcatggg cacggcgtgg ctgaccgcct accggatgct
    10441 gttcaccaag tccggcctgc gacccgggca gaccatgctc gtgcaaggcg cgtccggtgg
    10501 cgtgtcgacc gcgttgatcg agctgggtcg cgcggcgggc atgcgggtgt gggtgacagg
    10561 gcgcaccgag gcgaagcgtt cgctggccct cgacctcggc gcccacgaga ccttcgagtc
    10621 cggcgcgcgc ctgcccgagc gggtcgacgc cgtcttcgaa acggtcggca aggccacctg
    10681 gtcgcacacc atgaagtccc tcaagcccgg cggcatcgtc gtgatctcgg gcgccaccag
    10741 cggcgacgcg acggcggccg aactgcagcg gctgttcttc ctgcagctgc gcgtcgtcgg
    10801 ctcgacgatg ggcacccgcg aagagctcgg cgacctgctg cgcttctgcg accaggccgg
    10861 catccggccc aagatcggct ccgaactccc gatgaccgag gcggcacaag gcatgcgcgc
    10921 catgctcgac ggcgagacga acgggaagat cgtcttcacc cggtaggcac gccgccgggc
    10981 acggtcgagc tgaagatcac gtccgaggcc acaggccgga aggtgaggac gtcgccggac
    11041 gagccgcagt acctggtgcg cagcgacaag tccggcagga ccgcggtcag gccagccgct
    11101 tggtggcggt ggcgagcgct tcgcgcgcct cggctaccag cgtggccatc acctcggcca
    11161 ccggcgcctc gacggcctgc cggtaggttg tccccgccca catggacacg gcctccggat
    11221 cgccggcggc cgcggccgcc gcgcgcaccg gcttggtcag gtggtgcagc tgcgggtagg
    11281 cggccggtgc ctgctgctcg tgctcggtca tgaagcggtt cagcagcccg cgcgccggtc
    11341 tgccgctgaa ggcgcgggtc agcgcggtcg gcctcgcccc ctcggccagc tcggtgcggt
    11401 ggaccttgga cgtgcctgcc tccgggcaac gcaggaacgc cgtgcccagc tgggcggcca
    11461 ccgcaccggc ggccagcacc gcggccacgt cggcaccgcg gatcaggcca ccggcggcca
    11521 ccagcggcag gtcgacctcg gcggcgacca ggcgcagggc gtccagggtg ccgaacaggt
    11581 caccgccacc gggcagccac ggatcgtcct cgaagacacc gcggtgcccg cccgccgaca
    11641 tgccttgcac gcacagcgcg tccgctcccg tcgcggccgc gcgagcggcc tcggccgggg
    11701 tggtgaccgt gaccgtcacg tggatgccgg cgtcgcgcag ccgggccaca tcgtcgggca
    11761 gcggcgcgcc gaaggtgaac gacacggccg cgacccgctc ggcgacggcg aggtcgagct
    11821 tcgccgcgta gtggtcgtcg tcccagccgg gccggccttc ggtggtgtcg tagcgcgccg
    11881 cctcggcggc caccaccgcc tggtagcggc tgaggtccac cgtggaccgt tgaccgggcg
    11941 tgaacaggtt gaggccgaac ggttgcgtgg tcagctcgcg ggtcgcggcg agctgggcgc
    12001 gtacggcatc cggcgtcagg tacccggccg cgaggtagcc gaagccgccc gcgtcgcagg
    12061 ccgccgcgac gagctcgggc gttgacggac caccggccat cggcgccgcg atcaccggca
    12121 cccgcagctg cgcgaacatc cctcgacggt aacccgaacc gggccgtgcc ggccgcgtgg
    12181 gatagtccac gcatgccgtt catggtcgag gacgcgatcg cgatcgccac gaaggcccac
    12241 cggggccagc gggacaagtc gggtcacgcc tacataggcc acccccttcg ggtgatgggc
    12301 atgatgcgca ccgaccacga gcgcatgacc gccgtcctgc acgacgtggt cgaggacacc
    12361 gaggtcacgg cggacgacct gcgcgcggcc ggctgcccgg acgccgtggt cgaggcggtg
    12421 atcgccatca gcaagcgccc gggtgaggac cacgaggact acctcgcccg tgtggcggcc
    12481 aacccgatgg cgctcgcggt gaagcgcgcg gacatcgccg acaactcgtc ccccgagcgc
    12541 atggacgaac tcgacgggcc gacccggtcg aggttgcgcg ccaagtacga gaaggcaacc
    12601 cgcctgctgg acacctattc acgagcctga cccagcaatt cagcgagaac gatccgcacc
    12661 gggaagggct gggtcgcctc gaacacctcg tcttcttgga cttcggtcgt cagccgatag
    12721 gcgccatcca ccagatcgaa cgccacgagg ctcggcggcc cggggtcgac gacccagtag
    12781 ctcggaactc cgagtcgttc gtacaccgcc ttcttgttgt tgagatcgtt gatggccgaa
    12841 ctgtgcgaca ggacctcgac ggcgagcaac ggcgcgacgg gcagacagtc ctcggtcaga
    12901 tccgatcttc tcgccgccaa gccatccggt cgcagttcaa gggttggcga cggtcgcacc
    12961 gcgaagggac ctaccagcac ctccacgtcg tccgggcacg acatctccaa cgccacgagc
    13021 aacttcatga cggccttctg gtggcggaag ccaggcaatg ggctcacaac gagcatcccg
    13081 tcgatgagct cgtagcgacg accatcgtcc ggcatggtgg caaggtcgtc cacggtgaac
    13141 acgtctaccc ctttcttggt cgtggccaag ccaagcagag gggaccgaca attctgcgaa
    13201 cactgctcgc ggttcacccg gacgagcgac gcgactccag ttcggcgacc agtttcttcg
    13261 gcgcgacgca ccggtacgcg tccaccacga tctcgccgat ctcggcccag tcgacctcgc
    13321 cgtccagccg cacgccgagc cagccgcggt gcccgacgta gggcggccgg aagaaccggt
    13381 ccggttcctc ggcgaccaac tcctcctgca cgccaggagg tgcggcacac cagaacccgg
    13441 tgatgccgtc gccgtggtgg tcgtcgacgt acatcacgaa gaccttcttg acgaaccacg
    13501 tgggcgagcc gtggctgagc ttctcggtgg cctcgggcag cgcgaggcac agcgcgcgca
    13561 agcggtccag cggcggggag gccatgccgg gcagcgtaat cagaaggtga acgtcttcgc
    13621 gaacacgatc cagaagacga cgatcgcgac cagcccgagc accaggcaca ccgcgacacc
    13681 gacgagcagg ccacgcccca acggtttgcc cgccaacgac aacgcggcgc cgaggacgaa
    13741 ggcgacggcg agcacgaccc ccatcaccac ggcgaagtcg gcgtccatcc agccgaacgg
    13801 gtgcacgccc accgcgaaga gcccggcgac gagcaactcg acgaccacga cggccgccac
    13861 acccggcagg acgccttcgc gggtacggct cggagtcacg gggttacttc ttcttgtcct
    13921 tgccggtcgg ctcatcggtc gacaacgccg cgacgaaggc ttcctggggg acctcgacac
    13981 gccccaccat cttcatgcgc ttcttgcctt ccttctgctt ctccagcagc ttgcgcttgc
    14041 gcgtgatgtc accgccgtag cacttggcga ggacgtcctt gcgcatggcg cggatcgtct
    14101 cgcgggcgat gatgcgcgac ccgatcgccg cctggatggg cacctcgaac tgctggcgcg
    14161 ggatcagctc acgcagccgc gtcgccatcc gggtgccgta gccgtacgcc gcgtccttgt
    14221 gcacgatcgc gctgaacgcg tcgaccggct cgccctgcag caggatgtcg accttcacca
    14281 ggtccgaggc ctgctcgccc gactcctcgt agtccagcga cgcgtaacca cgcgtgcgcg
    14341 acttcaacga gtcgaagaaa tcgaagatga tctcgccgag cggcatcgtg tagcgcagtt
    14401 cgacccggtc ctcggacagg tagtccatgc cgccgagctg accgcgcttg ccctggcaca
    14461 gctccatgat cgtgccgatg tactcactcg gcgcgatgat cgtgcacttg gtgaccggct
    14521 cgaagatctc ggcgaccttg ccctcgggcc agtccgacgg gttggtgacg gtcagctcgc
    14581 cgcggtcgtc cagcacgacc cggtagacca cgttgggcgc ggtggagatc aggtccaggc
    14641 cgaactcgcg ctccagccgg tcgcgggtga tctccaggtg cagcagaccc aggaaaccgc
    14701 atcggaaccc gaaccccagc gccgccgacg tctccggctc gtaggtcagg gcggcgtcgt
    14761 tcagctggag cttgtccagg gcctcacgca ggtcggggta gtccgaaccg tccactggat
    14821 acagtccgga gtagaccatc ggctgcggct cgcggtagcc ggacaacgcc tcggtggcgc
    14881 ccttgcgctc cgaggtcacc gtgtcaccga cccgtgactg gcggacgtcc ttcacgccgg
    14941 tgatcaggta gcccacctcg ccgacgccga ggccctggct cggcttgggc tccggggaga
    15001 tgatgccgac ctcgagcagc tcgtgcaccg cgccggtgga catcatccgg atccgctcgc
    15061 gcggggtgat cttgccgtcc accacgcgga tgtaggtgac cacgccgcgg taggtgtcgt
    15121 agaccgagtc gaagatcatc gcgcgggccg gggcgtcggc cacgccgacc ggcggcggga
    15181 cctggcgcac gacctcgtcc agcagctcgg acacgcccat gccggtcttg gccgagaccc
    15241 gcagcacgtc ctcgggctcg ccgccgagga tgtgcgcgat ctccgccgcg tacttctccg
    15301 ggtcggcggc cggcaggtcg atcttgttca gcaccgggat gatgtgcagg tcgcggtcga
    15361 gcgccatgta gaggttggcc agcgtctgcg cctcgatccc ctgcgcggcg tcgaccagca
    15421 ggatcgcgcc ttcgcacgcg tcgagcgcac gggagacctc gtaggtgaag tcgacgtggc
    15481 ccggcgtgtc gatcatgtgc agcacgtgct gggcgccgtc gagggtccac ggcagccgca
    15541 cgttctgcgc cttgatcgtg atgccgcgct cgcgctcgat gtccatccgg tcgaggtact
    15601 gggcccgcat gtcgcgcgcc tggacgacgc cggtgatctg cagcatccgg tcggcaagcg
    15661 tggacttgcc gtggtcgatg tgcgcgatga tgcagaagtt gcggatctgc tccggcgccg
    15721 tgaaggtggt gtcggcgaac gtgctcactc aggtcccttg cgatgcggat cggcatgatt
    15781 caggcatggc cgtccgccat tgtcccatgc tgggctgtca ggccaggcga gtcatgtcca
    15841 ccgacacctc gatggccgac gcggcgccgc cggaataggt ccccttgagc ggggagacgt
    15901 cgccgtagtc acgcccgatc gccacccaca cgtgccgctg gccgatctcg atgtcgttgg
    15961 tcgggtcgaa gccccaccag cccccggtcc aggcctcgat ccacgcgtgg ctctcgccgc
    16021 gcacggtctc cccgatggcc ccgtcgggct tcgtgtgcag gtagccggac acgtagcggg
    16081 ccgggatgcc gatcgagcgc agcatcgcca gcgtgaggtg cgcgtagtcc tggcagacgc
    16141 cctcacgggc ctgccacgcg tcgatcgccg agctgtgcac gccggtggtg ccctggtggt
    16201 aggtcagctg gtcgtgcacc cactccgaca cggcgagcac ggcctccatc ggccgccgcc
    16261 cggtgcgcag cttgcgggcg atcgagatca gctccttgtt gcgtggcgcg taccgggtcg
    16321 gctccagcag ctcgccgtag cggtcggcga taccgtcacc gcgcaggtcc gcccaggagg
    16381 cgtcgtcgat cggctgcacg tgctcggtgg tctcgaccac ggacgacgcc acgatcttga
    16441 gctcggtgtg cggggcgtgc aggtcgaacg acgtgacctc ggtgccccag tagtcggtgt
    16501 agcggtagga gcgggtcgcg ggcgtggtct ccagccgcgc gaccacgagg ttctgccgcc
    16561 ggtcgctgcg cggggtgagc cgcgcctcgt tgtaggactg cacgaccggc gcctcgtacc
    16621 ggtacccggt cgtgtgcacg acccgcacgc gccagctcac cgggtccatc gtgccggtcc
    16681 tggattgccg cacggcctcc ggggtggtcg tcacaagctc acctccgcgt tggtccaggc
    16741 cacccagggc accgagtgga agtactgcag cgccacggct tcgccgacgt cgcggatgca
    16801 ctgctgcagg cccagcagcc gtccggtgag gtcctcgagc agctcctccg gacgcaggaa
    16861 ctccagctcg ctgcgggcct tgccgagcag ccgggacgcc tcggccttcg cccccacccg
    16921 ggtgctcggc tggttgtcga ggtggtccag gcacgactcg gcctggctca gggcgtggaa
    16981 caccgaccgc gggaagagcc ggtcgagcag caggaactgc acgacccggg tcgcgtccag
    17041 cgcgccgcgg taggtccgca ggtaggtgtc gtgggcgccg gcggaacgca gcacggtgac
    17101 ccagcccggc gacgacggct tgtcccccac ccgcgacatc agcaggcgca cgatcatgtc
    17161 gacgcgttcg acgaaccggc cgagcacgag gaaccgccag ccgtcgtcgc ggctcatcgt
    17221 ggagtcggcg agcccggcga acatcgcggc ccgctcctcg acgaaggaga agaacaggct
    17281 cgggccgacc cgtttcgcgg cccgctggcg ttccggcacc gcgttgtaca tcgagttgat
    17341 gcactcccac agctccgtgg acaccacttc gcgggccacc cgcgtgttct cccgcgcgct
    17401 gctgatcgac gacacgatcg agccggcgtg ctcgcgcgac atggcgacca gctcggtcag
    17461 cgtccacacg tccagctcca tgccgggtgg cggggtgatg ccgaggacgg tcagcagctg
    17521 acggctcgtc gcgtcggcgt cgaccgtggc gtcctcgagc agttggtgca ccgagacgtc
    17581 gaggatccgc gcggtgtcgt cggcccgctc gacgtagcgg ccgatccagt agagcgattc
    17641 agcgttgcgt gccagcaccg gatcctcctc actgctgctg ttgttgctgt tgctgcgccg
    17701 aggtcagctc gggcccgcgt tcgggagcgc tctcctcctg cggggtgccg agccgctgcc
    17761 cgctcagctc cgggtccaca gtggacgacc gagcggccag cacccaggtg tccttggaac
    17821 cgccgccctg cgaggagttc accaccagcg agccttccgg caccgcgacc cgcgtgaggc
    17881 cgccgggcag cacgaacacc gacttgccgt cgttgacggc gaacggccgc aggtccacgt
    17941 gccgcggttt gagccgttgc cccaccttgg tcggcacggt cgagagctgc acgagcggtt
    18001 gcgcgatcca gccacgcggg ttggcccgca cgcgcctgcg gatggcggcg agttccttgg
    18061 cgctggcgtc cgggccgaac acgatgccgt agccgccgga gccctcgacc ggcttgatca
    18121 ccagctcgtc ggcgtggtcg aagacgtact ggcgctcctc gcgcagccag cagcggtagg
    18181 tgtcgacgtt gggcagcagc ggcgcctcgt ccaggtagta cttcaggatc tcgggcaggt
    18241 aggtgtagac gagcttgtcg tcgccgacgc cgttgccgac cgcgttcgcg atcacgacgt
    18301 tgcccgcgcg ggccgcgttg atcaccccgg cgacgccgag caccgagtcg ggccggaact
    18361 gcacggggtc gaggtactcg tcgtcgatgc gccggtagat cacgtcgacc tggcgctcgc
    18421 cctcggtggt gcgcaggtag atcacgttgt cgcggcagaa caggtcacgg ccctcgacca
    18481 gctcgacgcc catcagccgg gccagcagcg agtgctcgaa gtaggccgag ttgtgcaccc
    18541 cgggcgtgag cacgacgacg gtcggatcgg cgacgttcgg cgcggccgcc gcgcgcagcg
    18601 cacgcaacag gtgcaccgcg tagtcgccca ccgcccgcac ccggtgcttg gcgaacaggt
    18661 cgggaaagac ccgcgccatc gtgcgccggt tctccatcac gtaggacacc ccggacggcg
    18721 agcgcaggtt gtcctccagc acccggaacg tgccgtcctc gtcgcgcacc aggtcgacgc
    18781 ccgagacgtg gatgcgcacg ccgttgggcg gcgagacgcc ggcggcctgg cggtggaagt
    18841 gcgcgcagga ggtgatcagg cggcggggca gcacgccgtc gcggatgatc tgctggtcgc
    18901 cgtagatgtc ggcgaggaac gcctcgaggc cgcgcacccg ctgcacgatc ccgcgttcga
    18961 gcttggccca ctcccccgcc gtgatcaccc gcgggatcag gtcgagcggg aacgggcgct
    19021 cctgaccgga caacgagaac gtgatgccct ggtcgacgag cgcgcggtcc agcgcctccg
    19081 cccgggtcgc gaggtcagcg ggcttcgacg gcgagagcga gtcgtacaac cggcgataag
    19141 cgctgcgcac ggtcgaatcc gcggcgaaca tctcgtcgaa ggcgcccgcg tgcggccgct
    19201 tcgggtcgag gtagttgtcg aacagatcgc cgttgccgct cgcccggttc atttccgcat
    19261 cttgtcccaa gcagacgcgg ttcaccaggc ttgacgatca tcgacaccgc gcgttaacag
    19321 tacgatcgcc ggtgacccac ccgtgcgccg tgaccagcgt gcggtccagg cagcggccgg
    19381 tgtcgtcgag cccgcgccac cgttcgctgg actggccgtc ggcgtaggtc agctggccgt
    19441 tcgtgcgacc gaacccgccg ctggtgtcga tctggtcgtc gctgaacgcg agcagcctcc
    19501 cgtgaccgag ctccgtgcgc aggacgcgtc ccatgtggac ggtcgcgtcg atgcggtagt
    19561 tgttcgagtc ggtgtaggcc gtggtggagt cggcgtcgag ggtgaagccg aaccggtccg
    19621 tgcggccgtt ggcggtgtaa gcgccgtcaa cgcggtgggt ggtctgctgg cgggcggcgc
    19681 tgtcggtgag gctcgtggtg ttggcgaagg tccactggcc gcccgccttc acggtgatcc
    19741 gcccttgcga ggtgtgcagg acgccctcgg tgtgccagct gcggtcgacg gtggtcgtgg
    19801 ccgtgacgtc gatcccggtg ccggtgaggt cggtgtgcac ctgcgcctcg gggacgtcgg
    19861 cggtgcgcag ttcgccggtg acccgcttgg tgtgcggatc ggtcgtggcg aagaggttcc
    19921 cgcccagcgt ccagacgtcg acgatgccct tcggcggcgt cagcgtgatc gtgtgcgcct
    19981 tgccgtcggt cagcgtgccg atgaagggac tcaggtcgat cgtgtacggc agcgtgacga
    20041 tcgcgtcgat ggcggagatc gggcgccaca gcatcggcgc gacgccgccg gtgtagatgg
    20101 tcgggtacgg catgaccgcg ccggccgggt ggccgtccac ggccacgtcg acctcgcggt
    20161 aggtgccgcc gccgcagagc ccggcgtcgg ggttgccctg gctgaccgag gtgggcacgt
    20221 tcgaccacca gaactcctcg cagccgccgc cgcgggcgta gatctcggcg gtcagcttgg
    20281 cggtgttgcc gggcacggtg acctgggcgt tgtaggtctg accgtcgccc agcgcctgcc
    20341 agccggggct gttgtggtcg gccgcgagcg ggagcacctt gtcggcctgg cgcggtgccg
    20401 ggtggtgccg gtcggccttg aagtaggtga tcgtgaccgt gacgtcgtag gggccggtgt
    20461 aggtgtcgtt gacgatgttg ccgaggtcga ccacgaacgg ttgcgcctgg tgcagcagcg
    20521 ggctgaactc ggtgatgtcc ttgtcgaagt gccaggtgat gccggtcggg tcgggctcgg
    20581 gtgtggaggt gcgcgcgacc tcggcgccgc cgatccagat gcccgcgagc cggtcgtact
    20641 ggcggcccgc gctggacgcg gtccagtcga ggacgacctt cgtccagtcg cccgcacagc
    20701 tgctcggcgg cgtgagcgtg ccgacgtagg gctggccgta ggagttggcg aagacgtggt
    20761 gcatcgcggt gaccgtgcag gagtcggtcg ccgggcggct caccgacggc aaggcctgca
    20821 gcgggtcctg gtagtcggtg accaccgtgt ccgcggtggc ttgggtggct ccgaggagca
    20881 ggaacgcggc ggtggcgatc aggagtcggc gcacgactgg cgacgctagt tcgctcccgg
    20941 cggtcgcggc agggggcgcg ggggcg
//
