LOCUS       NZ_SNXZ01000002        25677 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Labedaea rhizosphaerae strain DSM 45361 Ga0310470_102, whole genome
            shotgun sequence.
ACCESSION   NZ_SNXZ01000002
VERSION     NZ_SNXZ01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Labedaea rhizosphaerae
  ORGANISM  Labedaea rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Labedaea.
REFERENCE   1  (bases 1 to 1608339)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1608339)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004362825.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 13:11:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,753
            Genes (coding)                    :: 7,690
            CDSs (with protein)               :: 7,690
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 11 of 63
            Pseudo Genes (incomplete)         :: 55 of 63
            Pseudo Genes (internal stop)      :: 3 of 63
            Pseudo Genes (multiple problems)  :: 6 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:41:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 627603
            Orig. end                         :: 653280
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SNXZ01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25677
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25677
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25677
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15677](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15677
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            575..811
                     /locus_tag="EV186_RS12090"
     CDS             575..811
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_133849325.1"
                     /transl_table=11
                     /translation="MIAALLGVLMWLPVIVFGLFFVVPFLLDAVPPAMPRPPSRSPIQL
                     AEIAHRRTARRRHHTPVRRPPSVGARELEGRSK"
     gene            811..1185
                     /locus_tag="EV186_RS12095"
                     /old_locus_tag="EV186_102499"
     CDS             811..1185
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_102499"
                     /product="hypothetical protein"
                     /protein_id="WP_133849326.1"
                     /transl_table=11
                     /translation="MFHRRPANSMLRCVARRPRRQHDRGQRVAAFRRALTEWGWRADLG
                     HGRLACRDHHDRRAVLLVLPAEGGAVLIPSRPGPLYLPALTTGALRGVLQTAVLAPDPS
                     VPATERAAMTRRTAWFKAAA"
     gene            1182..1430
                     /locus_tag="EV186_RS12100"
                     /old_locus_tag="EV186_102500"
     CDS             1182..1430
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_102500"
                     /product="hypothetical protein"
                     /protein_id="WP_133849327.1"
                     /transl_table=11
                     /translation="MMISINIWWLIGGALVLLTAAVFAGLRWSGRPTRGKHSFYGDEVS
                     VRALTSSPPSTFGGRTCGRWPKTDRDEVLASLRRDRS"
     gene            1681..2469
                     /locus_tag="EV186_RS12105"
                     /old_locus_tag="EV186_102501"
     CDS             1681..2469
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.4"
                     /locus_tag="EV186_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102501"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_133849328.1"
                     /transl_table=11
                     /translation="MNRWIPADMDLESACTARIDDYVAGGTSNLAVDRAAAERLLTALP
                     EYPGFVVDSRRYALWAVDAMLSAGIDQFIDIGAGIDAVGVVDKLASWPESAARIAYVET
                     DPMCVAQLESRVHKDERVAVFPIDLFAPSWVTDPEGVWRLLAADRPVGLLMASIAHYEL
                     SDDVLASALTDIYDKVAAGSMLAITHLSGGQDPIAATRLEQAHTQAGFPVRARNRKELA
                     ALVRPWTPAPWAPNALPGALRLGIGLLARKAAPPSSSASS"
     misc_feature    2556..2571
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.91"
                     /tool="antismash"
     misc_feature    complement(2556..2574)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.43"
                     /tool="antismash"
     gene            2637..2876
                     /locus_tag="EV186_RS12110"
                     /old_locus_tag="EV186_102502"
     CDS             2637..2876
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_102502"
                     /product="hypothetical protein"
                     /protein_id="WP_133849329.1"
                     /transl_table=11
                     /translation="MTTPSAGAYIKVPAGCEITYRFDVDGDIEILLGSVHDGFELLFEP
                     AALARFTAVAEQALKANVDHGCEQTSTFTPAVVV"
     gene            2898..3656
                     /locus_tag="EV186_RS38865"
                     /old_locus_tag="EV186_102503"
     CDS             2898..3656
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS38865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_102503"
                     /product="hypothetical protein"
                     /protein_id="WP_166659090.1"
                     /transl_table=11
                     /translation="MSTSTVADLVMLRPQVPDEQVTTRTRPGMPEKGVSVFRGPHGPVP
                     YVAMWSAEEVQQGPLVETRQGIAYADESSVDRDHYGLLWSRVTSRQGVGEPRYRQMHPL
                     RQRRAMNRLLCQVCAGPADHNDDGTLWLVPDQPPLWPGWPERSQTTQPPLCMRCARIAV
                     KACPSLKPGYIAIRAHSFVSGAWGGLYRTGWPQRPPILTEACTLNLGNPSLRWLQADQL
                     ARELVGCKLADLDRPAATSPSQASCPVQGA"
     gene            3659..3877
                     /locus_tag="EV186_RS12115"
                     /old_locus_tag="EV186_102504"
     CDS             3659..3877
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="EV186_RS12115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102504"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_208115574.1"
                     /transl_table=11
                     /translation="MPKTNGTLIRQRRQERGLTADELAARVGYSNAGSMRNIENRNDPA
                     AMTKLYRIARELGIAVDELLAADEKSS"
     gene            4335..5117
                     /locus_tag="EV186_RS12120"
                     /old_locus_tag="EV186_102505"
     CDS             4335..5117
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499987.1"
                     /locus_tag="EV186_RS12120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102505"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_133849331.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-10, bitscore:
                     39.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQAELVSADGITLEAAVHAARGGVGRRTVIQVHGINADMTEGGM
                     FVRLADRLADNDCDVLRFSFRGHGNSGGTSRGATIAGEMLDLEAAVAFATARFSGVLSL
                     VASSFGAVSACLALPWLAGQLEKLVLWNPVLDLARTFVRPELPWGKDNFGPAQQKSLWA
                     DGFLTIDDEFEIGRVLFAEFDHYRPLDRLMASPVETLIVHGDRDSAVSYDIARAAADEK
                     PGTVFHTVAGSDHGFDTREREDEAVGVTVQWIASEDPR"
     gene            5114..5779
                     /locus_tag="EV186_RS12125"
                     /old_locus_tag="EV186_102506"
     CDS             5114..5779
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_102506"
                     /product="DapH/DapD/GlmU-related protein"
                     /protein_id="WP_133849332.1"
                     /transl_table=11
                     /translation="MNVRSLYAAVRVDDSAVVGEHCVLGYPKEDRIRGEQLKPGSVLVG
                     EPVAIGARCVIGNHVVIHEGVRVSNDCVIDDRVRVGYNSSIGDRTRIAYGAYLCDRVSI
                     GEDACVAGFVCDGTRIGDRSTVMGELVHEYSQPHKGWWEVDEEPPVIDVDSVVGYGARV
                     VGAVRIGPRSYVAAGAVVTKDVPPEHVATGVNVHTPADRWTGRKLQDLLRHWMSARGR"
     gene            complement(5796..6500)
                     /locus_tag="EV186_RS12130"
                     /old_locus_tag="EV186_102507"
     CDS             complement(5796..6500)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499989.1"
                     /locus_tag="EV186_RS12130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102507"
                     /product="glycosyltransferase family 25 protein"
                     /protein_id="WP_279538299.1"
                     /transl_table=11
                     /translation="MVNLPRRPDRRAWIARSLPADLPVTYTCDWRGPFDGRELTAADLG
                     ARGYKLFPWQIDSSNPWWNRPLKYGEIGCTLAHLACWQDSVHNGQEWFTVILEDDAVLP
                     STFLDDLLVGIDLVARHQDFDLLYLGRVPLQPERERQLVTGFVVPAYSHCTFGYLLTRR
                     GLDRILATDPASALAPVDEVLPALYIDHPRADFRARFPKCLAAAAFDPPLVGQRPKDEA
                     GSDTEDSDFVES"
     gene            complement(6514..7770)
                     /locus_tag="EV186_RS12135"
                     /old_locus_tag="EV186_102508"
     CDS             complement(6514..7770)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_102508"
                     /product="hypothetical protein"
                     /protein_id="WP_208115575.1"
                     /transl_table=11
                     /translation="MLDSVVSNQSPSVDEVTAWLKRLRQGPALGRPMRAVRGLPPGLRS
                     LLIDDGSDGHGAASEAHTIVRRIQQAIAQLNDDDRTRVEVDLNLTSDHRYATLTQRQES
                     LAQLQKCAAKTISRNANRALDSLAYVLLTLETGNGPTTAARPSATQPHPDDVAPRESGP
                     EDLRSFWGLSPRSRVDIVCSEIPAEECPEYASPGDRNYLRYAKFADLDTLIYVRTRFAQ
                     LAPTATVRDFAPSEYYDTQADILVVVGGPPWNAKYREFLPQLPFHFEPHSAGEDDPLVV
                     PQLKRPILGPRWTARGELLEDIAVLTRLTLAQGTRVFLLGGCLTLGVLGAARCLLDDER
                     GSRSAHRIVREVGDADFVLAVEARRVGGITDIADLSATDPLILLSRKHTDPFTTVIDNS
                     ERYTYVSARAGHQHLVQPG"
     gene            8504..9703
                     /gene="fxlM"
                     /locus_tag="EV186_RS12140"
                     /old_locus_tag="EV186_102509"
     CDS             8504..9703
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155777.1"
                     /locus_tag="EV186_RS12140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102509"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_133849334.1"
                     /sec_met_domain="PCMT (E-value: 4.4e-41, bitscore: 137.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRALREMGAVRSDRVAEVFRAVPRHWFTPGAPLDKAYAPRDAVH
                     MKHDEQGRPISTVSSPQLQGSMLEQADIQPGMSALEIGSGGVNAAMMSWLTGPEGRVVT
                     VDIDPDVTARARQLLDAAGYQRVQVVLADADNGVPEHASYDRIIVTVGAWDIPPAWVEQ
                     LAPGGRLVVPLRMRGLTRSLELVREGNHLVSRSSLMCGFVAMQGAGANGGQMLPIRDGK
                     AELQFDDGWPGPERPALEGALDTSRVDAWSAVMVGGMESLDLLQLRLATTFSGFGRLAA
                     DEDQRPVLVEQGCIFFDSAVALPDSFAYLVARRSAGGSELGVHAFGPHAQDLAEAMVEQ
                     IQVWDQRYRGGPDPDFAIWPRDTPDDELPDGLVIDKRRCRISISWPPTTNRPHPHNIPK
                     "
     gene            9755..9955
                     /locus_tag="EV186_RS12145"
                     /old_locus_tag="EV186_102510"
     CDS             9755..9955
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="EV186_RS12145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102510"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_133849335.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2e-15, bitscore:
                     52.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLAVTPLPNEHAPGERSAVDENELTLDLRVITDSLPMAKMACST
                     SDNCGGSTCGSACTSHVTQPL"
     CDS_motif       9755..9874
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTLAVTPLPNEHAPGERSAVDENELTLDLRVITDSLPMAK"
                     /locus_tag="EV186_RS12145_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9875..9955
                     /prepeptide="core"
                     /locus_tag="EV186_RS12145_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-7.30"
                     /molecular_weight="2356.6"
                     /monoisotopic_mass="2355.0"
                     /core_sequence="MACSTSDNCGGSTCGSACTSHVTQPL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTLAVTPLPNEHAPGERSAVDENELTLDLRVITDSLPMAK"
                     /leader_location="[9754:9874](+)"
                     /alternative_weights="2374.6"
                     /alternative_weights="2392.6"
                     /alternative_weights="2410.6"
                     /alternative_weights="2428.7"
                     /alternative_weights="2446.7"
     gene            10001..13324
                     /locus_tag="EV186_RS12150"
                     /old_locus_tag="EV186_102511"
     CDS             10001..13324
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="EV186_RS12150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102511"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_133849336.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-179,
                     bitscore: 594.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2e-14,
                     bitscore: 50.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPADAARTSATGPRPPWFRHTGLILARASTVPPGLELPNTLHLG
                     LDADLGADADETRGAVREWKAWLGRLWKRPEVRAALRVASPVLASKVDAIVAHDDASDQ
                     SSDQNDDRFDDRQMRRVVVSVSSYLRRWQRRATPFGLFAGIAPVTVGAAATRSASVRFG
                     DAHRTVARPDATWMDGVITALERHPDLLPQLRVVANDAGYHRGDRFVVPTRPDERTPQA
                     PAALEASVRCTRPVSAALELAHRPVLVADLIRPLQHRFAQAGAAAIGHLLAELIEIGVL
                     ISSLRAPMTSADPLDHLIRELDALDLADLPELAGHRRQLATIGEQLRSLTSRKPTDETT
                     DDTGHADNTVTALDAVTAKMRAAHRVPGRVIAVDVALDAEITLPRSVVHEAENAATTLL
                     RLTPYPFGDPIWRDYHARFLDRYGVGVVVGVRDLVADSGLGYPTGFLAAARPRPAYLLT
                     ERDTTLLTLIQQAALDGRSEIALTEQTIRDLRVGDHDKLVPPRRVELICQVHASSLDAV
                     TRGRFQLWIVGAPMHTNSAAARFAHLLTEHDRHQFVASYLNDPAGKDTARDSLPTQLSF
                     APRRLGNENITRAPQLLPYVMHLGEHAAYDRDVSPATGSQAETRIGIDDVGVTADARHL
                     LLVRLSTGQEIQPHIPHALEATTQTPPLARFLAEAASARCGAFGPPGFGAAHDLPFLPR
                     LRHGRIVLAAARWLLTTSDLPPSAEHSLTTWDHALDDWRDRWHVPTTVLLCESDRRLPL
                     DLTDHRDRALLRARLHRNRSGRIELRETGASDSHGWAGRPCELVIPLTATHQDATLRAS
                     TPRASTPLRVVARSDAALPGRSPVLRAHVHGHPQRFDDALHDLHAFLADLQSPLRRWWF
                     WRHHDRSRPDGDQHLALCLRLHTAADYPIVAAQLADWAARLRAVDLLADLTLATHHAAA
                     IADPIDEALEEIRARDSAAALAQLTSAHRTGLANQAIAAVSLTDLAAALVATPDEGLQL
                     LVDTLPREHGRLDVQLSATSLAMVTAAGRPHPPTDAIARAWDHRRTALAAYRDQLLSPS
                     RSASTSTGLSADIRPALPALLHEHHLRAVSVDPGVEKVTFRLARAVAQRRLALGRRNAP
                     "
     aSDomain        10586..10864
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EV186_RS12150_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.70E-16"
                     /identifier="RREFam001.1"
                     /label="EV186_RS12150"
                     /locus_tag="EV186_RS12150"
                     /protein_end="288"
                     /protein_start="195"
                     /score="50.6"
                     /tool="antismash"
                     /translation="VVANDAGYHRGDRFVVPTRPDERTPQAPAALEASVRCTRPVSAAL
                     ELAHRPVLVADLIRPLQHRFAQAGAAAIGHLLAELIEIGVLISSLRAP"
     gene            13321..14664
                     /locus_tag="EV186_RS12155"
                     /old_locus_tag="EV186_102512"
     CDS             13321..14664
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155774.1"
                     /locus_tag="EV186_RS12155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102512"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_243753987.1"
                     /sec_met_domain="LANC_like (E-value: 5.1e-43, bitscore:
                     143.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAYTMATSTPDATPTATAVQADSLVHTLATALATPPSGPADTRE
                     LAGREQSLDRGTAGIALLHVERALTGTGSWSTAHAWIRAATACDISAADDTGLYLGAPA
                     IAFLLHAANSDNIDHAGRYHKALSTLDAHVEALAHRRVDAATARLDRGESTSFADYDVI
                     RGLTGIGRLLLYRAPAACMSQANALSRVLRYLIRLTHPRSDGRPGWWVDHHPDPALPTP
                     GGHANHGLAHGIAGVLAFLGTALRRGVTVDGHHDAIATLGAHLDHWQQDNPSQTTPNPA
                     GPLRRNWWPTWITHDDIHTGHPLQPGPPRPSWCYGTPGIVRALQIAAIATGDTARQRRA
                     EHVLVGCISDSHQLAHLSDVGLCHGWAGLYQTVWRAAQDATTSDLPHHLPNLTTQLTRQ
                     ASQYVSRPTTRPGDPTFLTGTAGLALALHTATHNTAPRSGWDACLLIN"
     gene            14646..15677
                     /locus_tag="EV186_RS12160"
                     /old_locus_tag="EV186_102513"
     CDS             14646..15677
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155773.1"
                     /locus_tag="EV186_RS12160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102513"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_133849337.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.8e-37, bitscore:
                     125.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADQLTTAATTPAEDTTETLNDTVTVIETAVGHVLTGTSLAVAA
                     TAAGIDATSLRDAVEVYRQAGRRALHEHANPGWWQVYLRFADWDQAEHTARTHLLPLLN
                     HARNRHWITDWWFIRKHPCWRLRLQPGPAAPTTNAVEQHLVGDLDKLTHHGHIHSWWPG
                     IYEPETAAFGGDHAMNALHSLFSADSHAILTHLGDTHIPLGRRELTLLLCSTLMRAARL
                     EWHEQGDVWHRITQSRPLPSDIQPGKVTALANQMKSVLLADLTVGGSVIDNDHPLAAAL
                     EWVHAFRHAGIALGAAALNGTLQRGIREIMTYLVIFHWNRLGLDTRTQAILAAAARAAI
                     LDT"
     gene            complement(16135..16572)
                     /locus_tag="EV186_RS12165"
     CDS             complement(16135..16572)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_133849338.1"
                     /transl_table=11
                     /translation="MGDPARWLAQDALERLALPWLDRKRANIARRRYSTYEDSSLKPSA
                     DGPLSIVVRDYGMNDRGFDVFVGEIPEPFELDDNDKRDRQEFETLVRAVLEGRVTITVA
                     RTPLGQRIREVAWDDNSWSVPRYLSLSAVRLSVHSRVFPAY"
     gene            complement(17070..17372)
                     /locus_tag="EV186_RS12170"
     CDS             complement(17070..17372)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS12170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_133849339.1"
                     /transl_table=11
                     /translation="MVKIKRADRVLRRRGGAAFGLLVIVGALVGVVVGLVKTITSTTMA
                     DQWQFIAATLPVIWLVWLVGPHPRIILYDDTLVAVNWFVRYEIPWAVVDSIDAKG"
     misc_feature    complement(17352..17368)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(17631..18251)
                     /locus_tag="EV186_RS12175"
     CDS             complement(17631..18251)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03696.1"
                     /locus_tag="EV186_RS12175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RHS repeat-associated core domain-containing
                     protein"
                     /protein_id="WP_133850208.1"
                     /transl_table=11
                     /translation="MADRAPGTTAAARTSALRLARARRRGSRVATIVELPASQDAADPA
                     TGITGWADYTEYGTPRDPAATAAVGGDRGYGWLGAKQRSTTDTFSAGLTLMGDRLYNPA
                     TGRFTSTDPEPGGSDTSYAYPTDPINAYDLNGHWWHWISSAAHAVGRGLSNAGRWAWQH
                     KWEIATGALAVGCVFMTAGVCMACRGWATARPDYSRARHYRTS"
     gene            complement(18358..22980)
                     /locus_tag="EV186_RS12180"
                     /old_locus_tag="EV186_102514"
     CDS             complement(18358..22980)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013955.4"
                     /locus_tag="EV186_RS12180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102514"
                     /product="RHS repeat-associated core domain-containing
                     protein"
                     /protein_id="WP_133849340.1"
                     /transl_table=11
                     /translation="MADGQTNIYNDASQGPYDGADDTLTGVVNNSSRPVSSLQLSSNTD
                     LFGFDGDGLCTVSPQPDGCPLGVTGYEGPNTSFSNVSADATGGVVNFTTPLQPGETAYF
                     SLEEALTATAVFSGGPSVTEQGGAPNPSEHASVCYAKAPINCATGVFVHQFNDITVPGR
                     GTALTFARSYSSADAAIDGPLGFGWSDGYAMSLATDATGNVVVRQEDGSTVSFTANGSG
                     GFVAPPRVLATLTADGSGGYDFTRRSTQVRYSFSSTGQLMEETDLNNNVTHLTYSNGHL
                     DTVTDPAGRTLHFAYTGSRIASITDPMGRTESFSYDTAGNLVSAADRASRIWHFTYDAS
                     HQLLTMTDGRAGTVTNTYDASGRVIAQADAAGLKTTWAYTGDPTSPSGGSTTMTDEHGN
                     QTVSTYANLELTSVVHAAGTAAAATTSFTYDIATLGRTTVTDPAGHVTINQYDRAGNLT
                     ATTTPAGETSSYGYNSLAEVTSKTTPAGETTSLAYDSAGNLTTVTDPLGHSTTYSHGDS
                     GHPDDVTSITDPDGRTKTMAYDAAGDVVSVSVSPTAGHTDTTLAVYNADSERTCQTAPA
                     ATAAGTRCPDTGGSHTANTTMWNYNPDGDLTDLTDPLGHVGTNDYDANGNLVRAVDPLG
                     NITTTSYDADNRTTATTKGVGTAAPSTTTFAYDLAPGSGACTASITGASYCGTATDPNG
                     HLTVDYFSVRDQLLAEVRPGNQTTSHAYDLAGNESTRTDPAGRTTSYTYDADNRLTNLS
                     YDGTTPAVSYSYDTDSRRIAMADGTGTTTYAYDPTSRPTSITDGHGNLLSYSYDGAGNN
                     VTLTYPNGHTVLRGFDGAGRLNSTTDFTGHTSTFSYDPDGNLTTTTYPNGDTVSAQFDA
                     ADELTATQAASTASTSTPLASLTYTRDSAGQVTRETASAALTGTNTYGYTAKLELANAN
                     GSAYTYDLSGNPTKLGTAVTQTFDSSNQLTATTSATTTTHYAYDANGNRTSAAPDAGTA
                     YTYSYDQANRLTTVTSSTVTAPPVLIAITPQSGPTTGGTTVTLTGTGFRGATAVSFGQT
                     AVAFSVASDTTITAVSPSGTGTVDVTVTTPVGSTALTPADRFTYTTSPGAKPTVTLVVP
                     NRGRTTGGDLVAIAGTHLDHATAVHFGPTAARFFQSPWLPNLILAASPPGHGTVDITVT
                     TAAGTSPKTSRDRFTYLSYRSNLPLSDQWKVPANYRTTATPLPKPATAPRVATAPSATV
                     ATYTYNGDGLRSTKQTGPTSQTFVWDPAGQQPQLLLDGSTAFIYGPDGHVIEQIDSTGA
                     ASYYFHDQLGSTRALLGSDGKISATFAYDAFGRTTSQMGTNQTPLQFAGGYRDGETGFI
                     YLINRYYDPATGQFLTVDPALDVSLSAYDYTEDNPVNETDPTGLFLHIALGAAVGAFAG
                     TIVGAGGYLVDVGFGGESFSWRGLGGATAGGFVGGAAAGSCEAASLGTATPLCLAISGA
                     GGELVNQTITGRFDPWGLATATVFSSLVPNPFKLIGRRPTSLTNIWKTGVNTWRMFGND
                     FFDSIGDSVTQRLLRRGSTC"
     gene            complement(23831..24634)
                     /locus_tag="EV186_RS12190"
                     /old_locus_tag="EV186_102515"
     CDS             complement(23831..24634)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645864.1"
                     /locus_tag="EV186_RS12190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102515"
                     /product="hypothetical protein"
                     /protein_id="WP_243753988.1"
                     /transl_table=11
                     /translation="MMSSSALSAPTVTRTLRVPEITAYFWIIKGLSTALGESASDYMVR
                     ALSPVIAVALGFLAFVAALIVQFSMRRYAAPAYWTAVVMVGIFGTMAADVLHVGFGVPY
                     FASATLYAVVLAAVFVIWQRTEKTLSIHAIDSWRREGFYWAAVVATFALGTAVGDLTAV
                     TLNLGYLVSIALYAGLIMVPAAGFRWLNWNPILSFWAAYVLTRPLGASPADWLGKPTDA
                     GGVGVGSGWISLVLAMAIVGAVSYLTTTGVDRPGRRELRPTSRTR"
     misc_feature    24625..24639
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.28"
                     /tool="antismash"
     gene            complement(24665..25324)
                     /locus_tag="EV186_RS12195"
                     /old_locus_tag="EV186_102516"
     CDS             complement(24665..25324)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102391.1"
                     /locus_tag="EV186_RS12195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_102516"
                     /product="response regulator transcription factor"
                     /protein_id="WP_133849342.1"
                     /transl_table=11
                     /translation="MTVRILLADDQPLLRMGFAMVLNSQPDLQVVGEAADGGRAVAAAL
                     ELRPDVVLTDIRMPGMDGIEACRELVTVLPSCRVVILTTFGLDEYVFAALRAGASGFLL
                     KDCPPEELLAGIRAVADGDAVMAPRITRRLLDTVVHHLPEAAAPVHQDLARLTDREREV
                     LESVAGGLANAEIAGKLQVSEATVKTHIGRILHKLELRDRVQMVIFAYDTGIVRPS"
ORIGIN
        1 agcgacgcag cgcccgagcg acgcgccgtt gccgcacgtt cggcggctgc tggcttggtg
       61 gcacttcgac ctccgttgac ctgggcggta gtccgccgtg acgcctgcac cttatcgact
      121 cgcaacctca tcctcagcag tggccgggaa gtttcgtgag tgagcacttg cgctggtgca
      181 aacttgcacc cattataggt gcagaggttg cagaggagag tcagatgatc gcggaacgtc
      241 catggggcgg taggagcgag agaagccgct acctggcgct cgctcgcgtc gacctgccgt
      301 tctcgccctc ctccccagac cgtccggcga gcgtccgcgt tgccccaggg cgctcgccgg
      361 acttccacct gaccggcccg tgccggtcgc acgcggtggg tgtggattcg cgtccacgcc
      421 ggaggtgcgc cgaaccatcg cgtgattccc ggggccggcg gcacgcatcg gcgacacgcc
      481 cgccaaccgc cggtcctgcg cggcccgtgc gatctgccat ctccgcgatc ctggatcgcg
      541 cgggccgccc cacctccacg cgggcggtgg cgtcgtgatc gccgcgctcc tgggtgtgct
      601 gatgtggctg ccggtcatcg tgttcgggct gttcttcgtc gttccgttcc tgctcgacgc
      661 ggttccgcct gccatgccga ggccgcccag tcgcagtccc atacagctgg ctgagatcgc
      721 tcatcgccgc accgctcgcc gacggcacca cacgccggtt cgtcgtccgc cgagcgttgg
      781 agcgcgtgag ctcgagggaa ggagcaagtg atgttccacc gcagaccggc caactcgatg
      841 ctgcgctgtg tggcgcgccg cccacgcagg cagcacgacc gcggccagcg agttgccgcg
      901 ttccgccggg cactgaccga atggggctgg cgtgccgacc tcggccacgg ccgattggcg
      961 tgccgcgacc atcacgatcg acgtgcagtg ttgctggtgt tgcccgctga gggcggcgcc
     1021 gtgctgattc cgtcacgtcc tggcccgctg tacctgcccg ccctgaccac tggcgctttg
     1081 cgcggcgtgt tgcagaccgc cgttctggcc cctgacccgt ctgtgcccgc gaccgagcgc
     1141 gccgcgatga cccgacggac ggcctggttc aaggcggccg cgtgatgatc tcgatcaaca
     1201 tctggtggct catcggcggt gccctggtcc tgctcaccgc tgctgtgttt gccggtttgc
     1261 ggtggagcgg tcgaccgacg cgcggcaagc actcgttcta cggcgacgaa gtctcggtcc
     1321 gcgctctcac ctcgtcgccc ccttcgacct tcggtgggcg gacgtgcggc cgatggccca
     1381 agacggaccg ggacgaggtt ctcgccagcc tgaggaggga caggtcgtga ccaaggcagc
     1441 cgcagtgagc cgccactgca cgatgccgag cacctggctg cctggcctgc tcgacccggg
     1501 cgaggagcac gtgctgcaga cctgcgacgg cgtgccacgc cagtgtccag cgcctggcgg
     1561 tccagtgccg gtagcggtgt gccgtgcatg gctcacggcc gatcccagcg cgcggcgatc
     1621 gggggcccga cggtgccgac gctgtcgtga actcgtcggc cagccgaagg acacaggatc
     1681 gtgaaccgct ggatacctgc tgatatggac ctggagtcgg cgtgcacggc acgaatcgat
     1741 gactacgtcg ccggcggcac ctcgaacctg gcggttgacc gtgcggccgc tgaacggctg
     1801 ctgacagcgc tacccgagta tccgggattc gtcgtcgaca gtaggcgata cgccctgtgg
     1861 gctgtggacg ccatgctcag tgccggaatc gaccagttca tcgacatcgg cgccggcatc
     1921 gacgccgttg gggtcgtgga caagttggcc agctggcccg agtcggccgc gcgcatcgcc
     1981 tacgtggaaa cagatccgat gtgcgtggcg cagcttgaat cgcgcgtgca caaggacgaa
     2041 cgcgtcgcgg tcttccccat tgacctgttc gctccgtctt gggtgacgga tccagagggc
     2101 gtgtggcgcc tgctggccgc ggaccgtcca gtcggtcttc tgatggcctc gatcgcgcac
     2161 tacgagttgt ccgacgacgt cttggcttcc gcgctgaccg acatctacga caaggtcgcc
     2221 gcgggcagca tgctggccat cactcatctc tcgggcggcc aagaccccat cgcagcaact
     2281 cggctggaac aagcgcacac ccaggccgga ttccccgtcc gcgcacgtaa ccgcaaggaa
     2341 ctggcagccc tggtgcgacc ctggactcca gcgccttggg caccgaacgc cctacctgga
     2401 gccctccggc tgggcatcgg cctccttgca cgcaaggcag cgccaccatc gtcctcggcc
     2461 agctcgtaga gacggcctga cggcgggcag aagccacatc acctttagct cgtcgcaccg
     2521 acccgcgtcc gtagcactgt ccacagtgga gcgccaatga ggagcattct catgaacacc
     2581 aacatgatca tcggaccttg tcgacgcttg aagcgccggt tggaggtggc gtacgcatga
     2641 ccactccgtc cgcaggcgcc tacatcaaag ttccggccgg ctgcgagatc acctaccgct
     2701 tcgacgtcga cggcgacatc gagatcctgc tcggttcggt acacgacggc ttcgaattgc
     2761 tcttcgagcc cgccgcgctg gcccggttca cggccgtggc tgaacaagcc ttgaaggcaa
     2821 acgttgacca cggttgcgaa cagacgtcca cgttcacgcc agcggtggtg gtgtaggtgg
     2881 cgggagttgc aggcatcatg agcacctcga ccgtcgcgga cctggtgatg ctccgaccac
     2941 aggttcctga cgagcaggtg accacacgca ctaggcctgg catgccggag aagggcgtgt
     3001 cggtgttccg cggtccacac ggccctgtgc cctacgtcgc gatgtggagc gccgaagaag
     3061 ttcagcaggg gccccttgtc gagactcgac agggcatcgc ctacgccgac gagtcctcag
     3121 tcgaccgcga ccattacggc ttgctgtggt cgcgcgtgac gtctcgccaa ggagtcggag
     3181 aaccccggta tcggcagatg caccctctgc gccagcgcag ggccatgaac cgcctgctgt
     3241 gccaggtatg tgccggaccg gccgaccaca acgacgacgg cacgctgtgg ctggttcccg
     3301 atcaaccgcc gctgtggcct ggctggcccg aacggtcgca gacgacccaa ccgccgctct
     3361 gcatgcgctg tgctcggata gctgtgaaag cgtgcccatc cctgaaacct ggctacatcg
     3421 ccatccgagc acactcgttc gtcagcggcg cttggggtgg gttgtaccgc actggatggc
     3481 cacagcggcc gcctatcctg acggaagcct gcacactcaa tctcggcaat cctagtcttc
     3541 gatggctgca ggccgaccaa ctcgcgcggg agctggtggg atgcaaactc gccgacctcg
     3601 accggccggc cgccacgtcg ccgtcccagg cgagttgccc cgtacagggc gcgtaacgat
     3661 gccaaagacc aacggaacct tgatccgcca acgacgccag gagcggggcc tcaccgcaga
     3721 cgaactggcc gctcgagtcg ggtacagcaa cgccggctcg atgcgcaaca tcgagaaccg
     3781 caacgacccg gccgccatga ccaagctgta ccgcatcgcc cgcgagctgg gcatcgcagt
     3841 cgacgaactc ctcgcggccg acgagaagtc gtcatgacgg gtacagacgg atcagccacc
     3901 gggcggcatc ggcttggaga ccacggtgtg tcttcgtcca tccggcggca cgaagcactg
     3961 atcgttgcgg tccgcgtcca cgtgccggga ccacgcagtg gctcgtgctt acgctgcggg
     4021 ttgttgtggc cgtgcgctga cttgttcatg gcgctcggga gcacgacagc caacgacacc
     4081 gagcgggatc ggtcaccgga accgccggtc cacgtggcca cgccgattcc accgccagcc
     4141 aggccgacgg aagtgaagca cgatctggac gttctccgtc gagttgcgcg cggcctgtcg
     4201 gctcttgact aggacgtcct gatgcgtgaa cgcgcaactg atcggctgat tgtgatccgg
     4261 gaccaagcga tcggctgcat gctagggcac acttccatca ctagaccgtg gagcgtcgct
     4321 aggagcgggc aggcatgttt caggctgagc tggtgtcggc tgacgggatt actttggagg
     4381 ctgcggtcca tgccgctcgt ggcggtgttg gccggcgaac ggtaatccaa gtacacggca
     4441 tcaacgccga catgaccgaa ggcggcatgt tcgttcgcct ggcagaccgg ttggccgaca
     4501 acgattgcga tgtgcttcgg ttctcgttcc gtggtcatgg caacagcggc gggacatccc
     4561 gtggggcaac catcgccggc gagatgctcg atcttgaggc ggctgtggcg tttgcgacag
     4621 cgcggttctc cggcgtcctt tcccttgtgg cgtcgagctt cggcgctgtg tcggcttgcc
     4681 tcgctctgcc gtggcttgcc ggtcagctcg agaaactcgt gctgtggaac ccggtcttgg
     4741 acttggccag gacgttcgtc cggccggaac tcccgtgggg taaggataac ttcggacctg
     4801 cacagcagaa gtccttgtgg gccgacgggt ttttgacgat cgatgatgaa ttcgagatcg
     4861 gccgggtgct gttcgccgag ttcgatcact atcgcccgtt ggacaggctg atggcgagtc
     4921 cggttgaaac gctgatagtg cacggtgacc gggacagcgc ggtgtcctac gacattgcgc
     4981 gagctgcagc tgacgagaag ccgggcacgg tctttcacac ggtcgctggt tccgatcacg
     5041 ggttcgacac gcgggaacga gaggacgagg cagttggcgt gaccgtgcag tggatcgcca
     5101 gtgaggatcc acgatgaacg tcaggtctct gtacgcggca gtgcgcgttg acgacagcgc
     5161 agtcgttggt gagcattgtg tgctcgggta tcccaaggag gacaggatcc gtggtgagca
     5221 actcaaaccc ggatccgtgt tggtcggtga accggtggcg atcggtgccc gctgtgtgat
     5281 cggcaaccac gtagtgatcc acgagggggt gcgcgtgagc aacgactgcg tgatcgacga
     5341 ccgagtgcgc gttggctaca acagcagcat cggcgatcgt acccgcatcg cttacggggc
     5401 ctacctttgt gatcgggtga gcattggcga ggacgcctgc gtcgccgggt tcgtgtgtga
     5461 cggcacccgc atcggtgacc gctccacggt gatgggcgag ctggtgcacg agtattccca
     5521 gccgcacaag ggatggtggg aggtcgacga ggagccgccc gtaatcgatg tggactccgt
     5581 ggtgggatac ggcgcccgag tggtgggtgc tgtccggatc ggcccgcgca gctatgtcgc
     5641 cgcgggtgcg gtggtgacca aggacgtccc gccggagcat gtggccactg gagtgaacgt
     5701 gcatacgccg gccgatcggt ggactggccg gaaactgcag gaccttctgc gtcactggat
     5761 gtccgcccga ggccggtagc cgccgatcgg ccgggtcacg actcgacgaa gtcggagtct
     5821 tcggtgtcgc tgcctgcttc gtccttgggt cgttggccga ccagaggagg gtcgaaagcc
     5881 gccgcggcaa gacatttcgg gaaccgggcc cgaaagtcgg cgcgtggatg gtcgatgtag
     5941 agggcgggta ggacctcgtc gaccggcgcg agcgcgctgg cggggtcggt ggcgaggatg
     6001 cggtcgagtc ctcggcgagt gagcaggtac ccaaatgtgc aatggctgta ggccggcacg
     6061 acgaaccccg tgaccagctg ccgttcacgt tcgggctgca gtggcacgcg accgagatac
     6121 agcaggtcga aatcctggtg tcgtgcgacg aggtcgatgc ccacgagcaa gtcgtcgagg
     6181 aaggttgaag gcaggacggc gtcgtcttcg aggatgacgg tgaaccactc ttgcccgttg
     6241 tggacggagt cctgccagca ggcgaggtgc gcgagggtgc agccgatctc gccgtatttc
     6301 agtggccggt tccaccaggg gttagacgag tcgatctgcc acgggaacag cttgtagccg
     6361 cgggcgccga ggtccgcggc cgtgagctcg cgtccgtcga acgggccccg ccagtcgcag
     6421 gtgtaggtca ccgggaggtc ggcgggcaac gagcgagcga tccatgcccg tcgatctggc
     6481 cgtctgggca ggttgaccac atacgtgcgg agatcagccc ggctgaacaa gatgctggtg
     6541 tcctgctcgg gcagaaacgt aggtgtagcg ctcggagttg tcgatcaccg tggtgaacgg
     6601 gtcggtgtgt ttgcggctga gcaggatcag cgggtcggtg gccgaaagat cggcgatatc
     6661 ggtgatgccg ccgacacggc gagcttcgac ggcgagcacg aagtccgcat caccgacctc
     6721 gcggacgatg cggtgcgcgc tgcgggatcc gcgttcgtcg tcgagcagac atcgggctgc
     6781 gccaaggacg cccagggtca ggcagccacc tagcaggaac acccgtgtgc cttgcgccag
     6841 ggtgaggcgc gtgaggacgg cgatgtcttc gagcagctct ccgcgagcgg tccatcgagg
     6901 ccccaggatg gggcgcttga gctgcggtac gaccaagggg tcgtcctctc cggccgagtg
     6961 cggttcgaag tggaacggca gctggggtag gaactcgcgg tacttcgcgt tccacggtgg
     7021 cccgccgacg actacgagga tgtctgcctg cgtgtcgtag tactccgacg gggcgaagtc
     7081 ccgaactgtc gcggtcgggg caagctgagc gaatcgtgtc cggacataga tgagggtgtc
     7141 gaggtcagcg aacttggcat agcgtaggta gttgcggtcg cctggcgatg cgtattcggg
     7201 gcattcctcc gcaggtattt ccgagcacac gatgtcgacc ctcgatcgag gtgacaatcc
     7261 ccagaacgat cggaggtcct caggtccgga ctcgcgaggc gctacgtcgt cgggatgagg
     7321 ttgcgtcgcc gatgggcggg ctgccgtggt gggtccgttc ccggtctcga gcgtgagaag
     7381 cacgtaggcc agggagtcca gggcacggtt ggcgttgcgg ctgatggttt tggcagcgca
     7441 cttctgcagc tgcgccaggg attcctgccg ctgggtcagg gtggcgtacc tgtggtcgct
     7501 ggttaggttg aggtcgacct cgacccgtgt gcggtcgtcg tcgttgagct gagcgatggc
     7561 ctgctggatg cgcctcacga tcgtgtgcgc ttcggacgcg gcgccgtgcc cgtccgaccc
     7621 atcgtcgatc aggagagagc gaagtccagg cggcaagccc cgcaccgcgc gcatcggccg
     7681 gccgagtgcg ggaccctgtc gtagacgttt gagccaggcc gtgacctcgt ctacggaggg
     7741 tgactggttg gacaccacgc tgtccagcat atgtccaccg gatagtcggc tgtccggcaa
     7801 ctggggtggt agatggcctg gcggccgagg ctccgaccgc cgaagctgat gatggtcact
     7861 gtcgacgtgt cgaccactga cggtggccac ccacatgccg gtccgcgatg acgttgtcga
     7921 cgttgcccgg ctggcgtgac cgtttcggga agccggggag gacatgcaga caccatccgt
     7981 tggacagcgg tcggcgaccg accggcgtgg ctggtggcgc tcctcaccgt ccttggatca
     8041 ccggccgtcc ctggttcgcc atggctgatc ccgtgtccgc cgacatgccg agagccgcgc
     8101 gcgggatcga ggcggtgctc gtcgagttgc tggaacgtcg caccggccca ccggagccag
     8161 ttcggcgccg tcacaggaga cgatcgatct gctcgccacg ctgagtcgcc tgaaggcgat
     8221 cattcctgcc ttttccaccg ccgtgatgac cggtattcct gtgggccggg aaacagtgca
     8281 tcagctggca gacctgctca cgacgtcggg ccagctcctg cgatcgcagg catcaaccgg
     8341 ccctgactcc cgtgtcatcc gaatggcgag atagccacgc gcaattcatt ctccggcggc
     8401 ggcccatacc ataggcgacg ataaggattc cgttttgagc tccactgaac aaccggcaac
     8461 gccggcgtcg attgatcctg cgagtgaggg accgcgcgag gcgatgattc gtgctctgcg
     8521 ggagatgggc gcggtgcgca gcgatcgggt tgccgaggtg ttccgcgctg tcccgcggca
     8581 ttggttcacg ccgggagcac cgctggacaa ggcgtacgcc ccgcgcgacg ccgtgcacat
     8641 gaagcacgac gagcagggca ggccgatcag cacggtgtcc tcaccacagc tgcagggctc
     8701 gatgctcgag caagccgaca tccagccggg catgagcgca ctggagatcg ggtcgggcgg
     8761 ggtgaacgcc gcgatgatga gctggctgac cggcccggag ggtcgggtcg tcaccgtcga
     8821 catcgacccg gacgtgaccg cgcgagcgcg gcaactcctc gacgcggccg gctatcagcg
     8881 ggttcaggtc gtgctcgcgg acgccgataa cggtgtgccg gagcacgcgt cctacgaccg
     8941 gatcatcgtc acggtcggcg cgtgggacat cccgccggcg tgggtcgagc agctggcgcc
     9001 gggcggccgg ctggtggtgc cgctgcggat gcgcgggttg acccgatccc tcgaactcgt
     9061 gcgtgaaggg aatcacctgg tcagccgctc gtcgctgatg tgcgggttcg tcgcgatgca
     9121 aggcgccggc gcgaacggcg gacagatgct gcccatacga gacggcaagg ccgagcttca
     9181 gttcgacgac ggatggcccg gccccgagcg tcccgccctc gagggtgcgc tggacacgtc
     9241 gcgagtcgac gcgtggtcag cagtgatggt cggcggcatg gagtccctgg atcttctgca
     9301 actgcggctg gccacgacct tttccgggtt cggccgactc gccgcggacg aggaccagcg
     9361 gccggttctg gtcgagcaag gctgcatttt cttcgactcc gccgtcgcct tgcctgactc
     9421 gttcgcctac ctcgttgccc gccgctccgc gggcggatca gagctcggcg tgcacgcctt
     9481 cggcccccac gcccaggacc tggcagaggc catggtcgag caaatacagg tatgggacca
     9541 gcggtatcgc ggcggcccag acccggattt cgcgatctgg ccccgggaca cccccgacga
     9601 cgagctgccg gacgggctgg tgatcgacaa gcgccgttgc cgcatctcga tctcctggcc
     9661 gcccaccacg aaccggccac acccgcacaa catcccgaaa tagcatcccg tcccgtcacc
     9721 cggcacacac ccacacaacg agggagaaac agccatgact ctggccgtca caccactgcc
     9781 caacgagcac gcacccggcg agcgcagcgc ggtcgacgaa aacgagttga cgctcgatct
     9841 gcgagtgatc accgacagcc tgcccatggc gaagatggcc tgcagcacca gcgacaactg
     9901 cggcggttcc acctgcggca gcgcgtgcac cagccacgtc actcaaccgc tctgaccagc
     9961 ccgccagagc aacaacgaac actggtcaaa gggaggcgac gtggacccgg cggacgcagc
    10021 acgaacctca gccacgggtc cacgcccgcc ctggttccgg cacaccgggc tgatactcgc
    10081 ccgagccagc accgtcccac ccggactcga gctaccgaac acgctccacc tcggccttga
    10141 cgcagacctc ggcgcggacg ccgacgagac ccgcggtgcg gtccgggaat ggaaagcatg
    10201 gctgggacgg ctgtggaagc ggcccgaggt ccgtgccgcg ctgcgcgtgg ccagcccagt
    10261 gctggccagc aaggtcgacg cgatcgtcgc ccacgacgat gccagcgatc aatccagtga
    10321 ccaaaacgac gaccgattcg acgatcggca gatgcggcgt gtggtggttt cggtctcgtc
    10381 ctacctgcgt cgctggcagc ggcgggcaac tccgttcggg ttgtttgcgg gcatcgcgcc
    10441 cgtgaccgtc ggcgcggcag caacccggtc ggcgtcggtg cggttcggcg atgcgcaccg
    10501 gacggtggcc cggcccgacg cgacgtggat ggacggggtc atcaccgcct tggagcgcca
    10561 ccctgatctg ctgccacagc tgcgagtggt cgccaatgac gccggatacc accgcggcga
    10621 ccgattcgtg gtgcccaccc gaccggatga acgcacacct caagcgccgg cagcgttgga
    10681 agcctcggtc cgctgcaccc ggccggtcag cgccgccctg gagctcgcgc accgtccggt
    10741 ccttgtcgcc gatctcatcc ggcccctcca gcaccgcttc gcgcaggccg gggccgctgc
    10801 gataggtcat ctgctggctg agttgatcga aattggtgtc ctgatcagca gcctgcgcgc
    10861 cccgatgacg agcgcagacc cgctggacca tctgatccgc gagctcgacg cgctcgatct
    10921 cgccgacctt cctgaactcg ccggtcaccg ccgccaactc gcgaccatcg gagaacaact
    10981 ccgctcgctg acatccagga aaccaaccga cgagacgacc gatgacaccg gtcatgccga
    11041 taacaccgtg accgctctgg acgcggtcac agccaagatg cgcgccgcac accgcgttcc
    11101 ggggcgggtc atcgctgtgg acgtcgcgct cgacgcggag atcacactcc cgcgatccgt
    11161 ggtgcacgaa gccgagaacg cggccaccac gttgttgcgg ctcaccccct atccgttcgg
    11221 tgacccgatc tggcgggact accacgcacg attcctcgac cgatatggcg tcggcgtggt
    11281 cgtcggtgtc cgcgacctgg tcgccgactc cggtctcggc taccccaccg ggttcctcgc
    11341 cgcggcgcgg ccccgccccg cgtacctgct gaccgaacgg gacaccaccc tgctgaccct
    11401 gatccagcag gcagctctcg acggccgcag cgagatcgcg ctgaccgagc agacgatccg
    11461 cgatctccgg gtgggtgatc acgacaagct cgtaccaccg cgccgagtgg agttgatctg
    11521 ccaggtccat gcctcgtcgc tcgacgcggt gacacgcggc cggttccagc tgtggatagt
    11581 gggcgcgccg atgcacacca actctgccgc cgctcggttc gcccacctgc tcaccgagca
    11641 cgaccgccac cagttcgttg ccagctacct caacgatccc gccggcaagg acaccgcgcg
    11701 ggactctcta cccacgcagt tgtccttcgc accgcggcga ctcggcaatg agaacatcac
    11761 ccgcgcaccc caactgctgc cctacgtcat gcacctcggt gaacacgccg cctacgaccg
    11821 cgacgtgtcg cccgccacgg gatcccaggc cgagaccagg atcggtatcg acgatgtcgg
    11881 ggtcaccgcc gacgcccggc acctgttgct ggtgcgactc tcgaccggac aagaaatcca
    11941 gccccatatc ccgcacgctc tcgaagcgac cacacaaacc ccgccgctgg ctcggttcct
    12001 cgccgaggcg gcgtccgcac gctgtggcgc cttcggcccg cccggcttcg gcgccgccca
    12061 cgacctgccg ttcctgcccc gccttcgcca cggccgcatc gtgctcgccg cagcccgctg
    12121 gctgctcacc acctccgacc tacccccatc cgccgagcac agcctcacca cctgggatca
    12181 cgcactcgac gactggcgtg accgctggca cgtcccgacg acggtgctgc tctgcgaaag
    12241 cgaccgccgc ctgcccctcg acctcaccga ccatcgcgac cgagccctgt tgcgcgcgcg
    12301 cctgcaccgc aaccgctctg gacggatcga gctgcgggaa accggagcct ccgacagcca
    12361 cggctgggcc ggccgaccct gcgaactggt catcccgctc accgcgaccc accaggacgc
    12421 cacgctccgc gccagcacgc cccgcgcaag cacgccgctg cgtgtggtgg ctcggtccga
    12481 cgctgctctg ccgggacggt cgccggtgct gcgcgcgcac gtgcacggcc atccgcagcg
    12541 tttcgacgac gccctccatg atctgcacgc cttcctggcg gacctgcaga gtccgcttcg
    12601 ccgctggtgg ttctggcgcc atcacgaccg ctcccgtcct gacggcgacc aacacctcgc
    12661 cctgtgcctg cggctgcaca ccgctgccga ctacccgatc gtcgcggctc agctcgcgga
    12721 ctgggcggcc cgattgcgtg ccgtcgatct gctggccgac ctgaccctcg caacccatca
    12781 cgccgcggcc atcgccgatc ccatcgacga agcactcgag gagatccgcg cccgtgactc
    12841 ggccgccgct ctggctcagc tgacgtcggc gcaccggacc ggactggcga accaggcgat
    12901 cgccgccgtg tcgctgaccg acctcgccgc ggcactggtc gccacccccg acgagggcct
    12961 acaactgctg gtcgacacac tgcctcgcga gcacggccgg ctcgacgtcc aactcagcgc
    13021 gacatcactg gccatggtca ccgccgccgg acgaccgcac ccacccaccg acgcgatcgc
    13081 gcgagcctgg gaccaccgcc gcaccgcgct cgccgcctat cgcgaccagc tcctcagccc
    13141 gtcacgttcc gcgagcacga gcaccgggct ttcggcggac attcggccgg ctttgccggc
    13201 gctgctgcac gagcatcacc tgcgtgccgt gagcgtcgac cccggcgtgg agaaggtcac
    13261 cttccgcctc gcccgagctg tcgctcaacg tcgcctcgca ctcggacggc gcaacgcccc
    13321 atgaccgcct acaccatggc aacctccaca ccggacgcca ctcccacggc gaccgccgtt
    13381 caggccgatt ccttggtcca cacccttgct acggcactgg ccactccccc atcgggtccc
    13441 gccgacacgc gcgagctcgc cgggcgagaa cagtcgctgg accgcggaac ggccggcatc
    13501 gccctgctgc acgtcgaacg cgcactaacc ggcaccggat catggagcac cgcccacgcc
    13561 tggatacgcg ccgcgaccgc ctgcgacatc agcgcagccg acgacaccgg cctctacctc
    13621 ggtgcgcccg ccatcgcttt cctcctgcac gccgccaaca gcgacaacat cgaccatgcc
    13681 ggccgctacc acaaggcatt gtccactctg gacgctcatg tcgaggccct ggcgcaccgg
    13741 cgcgtggacg ccgccacggc acgccttgac cgcggcgaat cgaccagctt cgccgactac
    13801 gacgtgatcc ggggactcac cggcatcggg cgcctgctcc tctaccgcgc acccgccgct
    13861 tgcatgtccc aggccaacgc gctctcccgg gttctccgct acctgatccg cctgacccac
    13921 ccccgcagcg acggacgacc aggatggtgg gtcgaccacc accccgaccc cgcactaccg
    13981 acaccgggtg gacacgccaa ccacggcctc gcccacggca tcgccggcgt gctcgcgttc
    14041 ctcggcacag ccctgcgccg cggcgtcacc gtcgacggcc accacgacgc catcgcaacc
    14101 ctgggcgctc acctcgacca ttggcaacaa gacaacccca gccagaccac ccccaaccca
    14161 gccggcccac tgcgcaggaa ctggtggccc acatggatca cccacgacga catccacacc
    14221 ggacacccac tccaacccgg acccccacga ccgagctggt gctacggcac ccccggcatc
    14281 gtccgcgctc tccagatcgc cgccatcgcc actggtgaca ctgcgcgcca acgacgcgca
    14341 gaacacgtcc tcgtcggctg catcagtgac agccaccagc tcgcccacct ctccgacgtc
    14401 ggcctctgcc acggctgggc cggcctctac caaaccgtgt ggcgagccgc ccaggacgcc
    14461 accacctcgg acctccccca ccacctgccg aacctgacca cgcaactcac ccgccaggcc
    14521 agccagtacg tcagccgccc taccacccgg ccaggcgacc cgaccttcct caccggaacc
    14581 gccggtctcg cactcgccct gcacaccgcc acccacaaca ccgctccacg ctccggatgg
    14641 gacgcatgtc tgctgatcaa ctgaccaccg ccgccaccac tcctgccgaa gacacgaccg
    14701 agacgctgaa cgacaccgtg accgtgatcg agaccgcggt gggtcacgtc ctgaccggca
    14761 catcgctcgc cgtcgctgcc acagccgccg gaatcgacgc cacctcgctc cgcgacgccg
    14821 tagaggtgta ccgccaagcc ggccgccgtg cgctccacga acacgccaac cccggctggt
    14881 ggcaggtcta cctccgcttc gctgactggg accaggccga acacactgct cggacccatc
    14941 tcctgccgct gctcaaccac gctcgaaacc gtcactggat caccgactgg tggttcatcc
    15001 gcaaacaccc ctgctggcga cttcgcctcc agcccggccc cgccgctcca accacaaacg
    15061 cagtcgaaca acacctcgtc ggcgacctcg acaagctcac ccatcacggc cacatccaca
    15121 gctggtggcc gggcatctac gaacccgaaa cagccgcgtt cggcggcgac cacgccatga
    15181 acgccctcca cagcctgttc agcgccgaca gccacgccat ccttacccac ctcggcgaca
    15241 cccacatccc ccttggccga cgcgaactga ccctcctgct ctgcagcacc ctgatgcgcg
    15301 cagcccgcct cgagtggcac gagcaaggcg acgtctggca ccgcatcacc caatcccgcc
    15361 cactacccag cgacatccag cccggcaaag tcactgcgct ggccaaccag atgaaatccg
    15421 ttctcctcgc cgacctcacc gtcggcggct cggtgatcga caacgatcac ccacttgccg
    15481 cagccctcga gtgggtccac gcattccggc atgccggcat cgcccttggt gcggcagccc
    15541 tcaacggcac cctgcagcgc ggaatccgcg aaatcatgac ctatctcgtg atatttcact
    15601 ggaaccgact cggcctcgac acccgaactc aagccatcct cgccgcagca gcacgagctg
    15661 ccatcctcga cacatgaccc agcgcgcaca gtccgggagt atgtccaggg acaagccgct
    15721 gattgccgcg tcgtagccta ggtcctaccg attcgacccc agtgaatgct cgatgccggc
    15781 ctggagccag actcgtgccg acctccgact cgatccatcg aagctcctcg ataacgttcc
    15841 tcgcgagcca accagcgcaa ggactggact gataaggccg ccctcaaaaa gttgatgcgg
    15901 cgttgaacgc gagattggcc cagtttaact cgcccggcgg tgaagcgctc gtgaaaggtg
    15961 tgcgctagga gcactccgcc ctagcagcta tgcagacgtc tgccgtcatt gaatacgcag
    16021 cctacggcga gcgcagcggt aggtgacttc gcacggggga tgtcatgctc agcgcccggc
    16081 cgacgttgct gacggcccgc gaggggtggg tccagcggaa agtgtcggtc cgggtcagta
    16141 cgcaggaaat acccggctgt gcacactaag cctgacagcg gacaagctca aatacctggg
    16201 aacagaccaa ctgttgtcgt cccatgccac ttcgcgtatg cgttgaccaa gcggcgtacg
    16261 cgccacggtg atcgtgaccc tgccttccaa caccgcccgt accaaggtct caaattcctg
    16321 tcgatcccgc ttgtcgttgt cgtcgagttc gaatggctca ggtatttcac caacaaaaac
    16381 atcaaacccc ctgtcgttca tgccatagtc tcgcaccacg atgctcagag ggccgtctgc
    16441 gcttggcttc agcgacgaat cctcataggt cgaatatcgc cgtctcgcaa tgttcgctct
    16501 tttgcgatcg agccacggca acgccaggcg ctccagggcg tcttgcgcga gccaccttgc
    16561 tgggtcgccc atgtgtgacc acgccgtcct acgaaaaggt ggtagtgaaa gtgcaccggc
    16621 gtccgaagac gcgggcgaag acatgtgcgg cgccactgac ccagtgccac cagtgtccgt
    16681 tgaggtcgta ggcgttggcg gggtcggcgg ggtggccgta ggtggtgtcg ctaccgccgg
    16741 gttcgggagc cgatactgat gaagcgtcca ctggtgagat ttgtggaggc gccgccaacg
    16801 aggccgccga agtggttacc gccgtgatcc tagcggacgg cagaccaccc tataagggct
    16861 agcacgactc ctacaacaag gggaaagagc ggcacgatgt cgagcctcgt cttgactcgc
    16921 gcctgttcac aagcttcagc tccatctttt gcctgaatta tcacgtttct catccgtgac
    16981 tgagtatcgt cctcgagcca gttgctgatc agcgcatgag caccgctcac gggcttgacc
    17041 acctgaccgt tacgcaattt gatcaacaat caccctttcg catcaatcga atctacgact
    17101 gcccaaggaa tttcgtaccg aacaaaccaa ttgactgcga cgagcgtatc gtcatagaga
    17161 atgatccgcg gatgaggtcc taccagccac acaagccaga tcaccggcaa cgtggcagct
    17221 ataaactgcc actgatcggc catagttgtg gaagtaattg tcttgacgag gccaactacc
    17281 acgccgacaa gggcaccaac aatcaccagt agtccgaatg ccgcgcctcc gcgccttcta
    17341 aggacacgat cagcacgctt tatcttcacc atgcgtgcct actccgcccg ttccacaatg
    17401 tcccagccga cagagagagc ccactgatgg ccgcgttgta acctaggttc ctaccggatc
    17461 gaccccagtg aatcggggct cgatgccgag cagcgccagc ccgacggtat cgcacggcac
    17521 cccatcgcgg ctcccggacg acgtttctca atcgccagcc ccgtgcaaga actcggccaa
    17581 gcaggccgcc accaaacgtc gatgctgcat tgaacgcgaa gttcgtccaa ttaactcgtc
    17641 ctgtagtgac gcgctcgtga atagtctggg cgagcagtag cccacccccg gcaagccatg
    17701 cacacacctg cagtcatgaa cacgcagcct actgcgagtg caccggtggc gatctcccat
    17761 ttgtgctgcc acgcccagcg cccagcgttg gataggccgc ggcctacggc gtgtgccgcg
    17821 ctgctgatcc agtgccacca gtgtccgttg aggtcgtagg cgttgatggg gtcggtcggg
    17881 taggcgtagc tggtgtcgct gcctccgggt tcggggtcgg tgctggtaaa gcgcccggtg
    17941 gccgggttgt aaagccggtc gcccatgagg gtcaggccgg cggagaaggt gtcggtggtg
    18001 gaacgctgtt tggcgccgag ccagccgtag ccgcggtccc cgccgaccgc agcggtggcg
    18061 gcggggtcgc ggggtgtgcc gtactcggtg tagtcagccc agccggtgat accggtggct
    18121 gggtcggcgg catcttgact ggcaggcagc tcgacgatgg tggcgactcg acttccgcgc
    18181 cgtcgtgcac gagcgaggcg tagcgcagag gtgcgggcgg ccgcggtagt accaggtgcc
    18241 cggtcggcca ggcgccgacg atggccgtca gcggaaactc gccttgggca gctccgttat
    18301 cccagctcat ccgggctcca agaaccggcg cggggttccc cgaactgtca ccatagatca
    18361 gcaggttgag ccccgccgta ggaggcgctg agtgacagag tcgcctatcg agtcgaagaa
    18421 gtcgttgcca aacatccgcc acgtgttgac gccggtcttc cagatattcg tcagacttgt
    18481 tgggcgacgt ccaatgagct tgaatggatt gggaacaaga ctgctaaata ccgttgcggt
    18541 tgccaaaccc cacggatcaa accgtcccgt aatcgtctga tttacgagct cgccgccggc
    18601 tccactgatg gcaagacaca atggtgtcgc ggttccaagc gaagcggctt cacaggagcc
    18661 agctgcagcg ccaccgacga agccacctgc ggtcgccccg cccagccctc gccagctgaa
    18721 gctctctccg ccgaatccga cgtcgacgag gtagccgcca gctccgacga tcgttccggc
    18781 aaacgcgcca acggcggcgc cgagggcaat atggaggaac aatcctgtcg ggtcggtctc
    18841 attgactggg ttgtcttctg tgtagtcata ggccgagagt gatacatcga gcgcggggtc
    18901 gaccgttaga aactgtccag tcgctgggtc gtagtatcgg ttaatcaggt agatgaagcc
    18961 tgtctcaccg tcgcggtagc cccctgcgaa ttgcagcggt gtttgattcg tgcccatctg
    19021 gctggtggtg cggccgaacg cgtcgtaggc gaaggttgcg ctgatcttgc cgtcgctgcc
    19081 gagtagtgcc cgggtggagc caagttggtc gtggaagtag tagctggcgg caccggtact
    19141 gtcgatctgt tcgatgacgt ggccgtctgg tccgtagatg aaggctgtgc tgccgtcgag
    19201 cagcagctgt ggttgttgac cggcgggatc ccaaacgaag gtctggctcg tcggaccagt
    19261 ctgcttggtg ctacggagac cgtcaccgtt gtacgtgtaa gtcgcgaccg ttgcgctcgg
    19321 cgcggtggcg actcgtggtg ctgttgcggg tttcggtagt ggcgtggcgg tggtgcggta
    19381 gttggctggg actttccact ggtcggagag ggggaggttg ctgcggtacg acaggtaggt
    19441 gaagcggtct cgcgaggtct tcgggctggt acccgcggcg gtggtcacgg tgatgtcgac
    19501 cgtgccatgg ccgggtggag aggcggccag gatgaggttg ggcaaccacg gagattggaa
    19561 gaaccgcgcg gctgttggcc cgaagtggac ggcggttgcg tggtcgaggt gggtgccggc
    19621 tatggccacc aggtcaccgc cggtggtacg gccgcggttc ggcacgacga gggtcacagt
    19681 tggcttggca ccagggctcg tcgtgtacgt gaagcggtca gccggggtca aggcggtgct
    19741 cccgacggga gttgtcacgg tgacgtcgac ggtgcccgtt ccggacggtg agaccgcggt
    19801 gatggttgtg tccgaagcga ccgagaacgc cacagcggtc tgcccgaagc tcaccgcggt
    19861 ggcacccctg aacccggtgc cagtgagcgt gacggttgta ccgccggtgg taggcccgga
    19921 ctgaggcgtg attgcgatga gaactggagg agccgtcacg gtgctgctgg tgaccgtcgt
    19981 cagtcggttt gcttggtcgt agctgtaggt gtaagcggtg cccgcgtccg gtgcggcgct
    20041 ggtccggttg ccgttagcgt cgtaggcgta gtgcgtcgtg gtggttgcgg aggtggtggc
    20101 ggtgagttgg ttggagctgt cgaaggtttg ggtgacggcg gtgcccagtt tggtggggtt
    20161 gccggatagg tcgtatgtgt aggcagagcc gttggcgttg gcgagttcga gcttggcggt
    20221 gtaaccgtag gtgttggtgc cggtgagtgc ggcgcttgct gtctcgcggg tgacctggcc
    20281 ggcgctgtcg cgggtgtagg tgagtgatgc cagcggggta ctggtgctgg cagtggatgc
    20341 ggcttgtgtg gcggtgagct cgtcggcggc gtcgaactgc gcgctgacgg tgtcgccatt
    20401 cgggtaggtc gttgtggtca ggttgccgtc ggggtcgtag ctgaaggtgc tggtgtgtcc
    20461 ggtgaagtcg gttgtcgagt tgagtcgtcc ggcgccgtcg aagccgcgca agacggtgtg
    20521 gccgttgggg taggtcaagg tcacgttgtt gccggcgccg tcatagctat agctgagcag
    20581 gttgccgtgg ccgtcggtga tggaggttgg tcgactggtc gggtcgtatg cgtaggtggt
    20641 cgtacccgtg ccatcggcca tcgcgatgcg gcggctgtcg gtgtcgtagc tgtagctgac
    20701 cgcgggggtc gtgccgtcgt aggacagatt ggtcaggcga ttgtcggcgt cgtaggtgta
    20761 gctggtggtt ctgccagcag ggtcggtgcg cgtggactcg ttgcctgcca ggtcgtatgc
    20821 gtggcttgtg gtctggttac cgggtcgcac ttcggcgagc agttggtcgc ggacgctgaa
    20881 gtagtcgacg gtgaggtgac cgttggggtc ggtggcggtc ccgcagtagg aggccccggt
    20941 gattgatgct gtgcaggccc cgctgccggg cgcgagatcg taggcgaagg tcgtcgtcga
    21001 cggcgcggcg gtgccgaccc ccttggttgt ggctgtggtc cggttgtcgg cgtcgtagct
    21061 ggtggtggtg atgttgccca gtggatcgac cgctcgtacg aggttgccgt tggcgtcgta
    21121 gtcgttggtg cccacgtggc cgagcgggtc ggtcaagtcg gtgaggtcgc cgtccgggtt
    21181 gtagttccac atggtggtgt tggcggtgtg ggatccgcca gtgtccgggc agcgggtgcc
    21241 tgcggcggtg gctgcgggcg cggtctgaca ggtccgctca ctgtccgcgt tgtacaccgc
    21301 gagcgtggtg tccgtgtggc cggctgtggg cgagacgctg accgagacca catcaccggc
    21361 tgcgtcgtag gccatggtct tggtgcggcc gtccgggtcg gtgatcgatg tgacgtcgtc
    21421 gggatggcca ctatcaccgt ggctgtaggt ggtggagtgg ccgagcgggt cggttactgt
    21481 cgtcaggttg cctgcgctgt cgtaggccag cgacgtggtc tcgccagctg gtgtggtctt
    21541 ggaagtcacc tcagccaagc tgttgtagcc gtagctgctg gtctcaccag ctggcgtggt
    21601 cgtggccgtg aggttgcctg ctcggtcgta ctggttgatg gtgacgtgac cggccgggtc
    21661 agtcactgtc gtacggccca gcgtcgcgat gtcgtaggtg aagctcgtgg tggccgcagc
    21721 cgccgtgcct gccgcatgaa caacagaagt cagttccagg ttggcgtagg tcgacacggt
    21781 ttggttgccg tgctcgtcag tcatggtggt ggagccgccg gagggtgaag tcggatcacc
    21841 ggtataggcc caggtggtct tgaggccggc cgcgtccgcc tgtgcgatca cccggccgct
    21901 ggcgtcgtag gtgttcgtga cggtgccggc tcgaccgtcg gtcatggtca acagctggtg
    21961 gctggcgtcg taggtgaagt gccagattcg gctggcgcga tctgccgccg acaccaggtt
    22021 ccctgccgtg tcgtagctga aggactcggt gcggcccatc gggtcggtga tggaggcgat
    22081 acgcgaaccg gtgtaggcga agtgcagcgt ccgaccggcc gggtccgtca cggtgtccag
    22141 atggccgttg ctgtaggtca agtgtgtgac gttgttgttg aggtccgttt cctccattag
    22201 ttgcccggtg gagctgaagc tgtagcgaac ctgggtactg cgtcgggtga agtcgtagcc
    22261 accggagcca tcagctgtca gcgtggcgag tactcgcggc ggggcgacga agccgcccga
    22321 accgttggcg gtaaacgaca ccgtcgagcc gtcctcctgc cggacgacca cattgccggt
    22381 ggcgtcggtg gccagcgaca tcgcgtagcc gtctgaccag ccaaagccaa gcgggccgtc
    22441 gattgctgcg tccgccgagc tgtagctgcg cgcgaaggtc agggctgtgc cgcgccccgg
    22501 cacggtgatg tcgttgaact ggtgaacaaa cacgccagtc gcacagttga taggagcctt
    22561 ggcgtagcag accgaggcat gctccgacgg gttcggcgct ccaccctgct ccgtgacgct
    22621 cggcccgccg gagaacaccg ccgtggccgt cagcgcctcc tcgagcgaga agtaagcggt
    22681 ttcgccgggc tgcaacggcg tcgtgaagtt gacaacgccc ccggtggcat cggccgagac
    22741 gttggagaag ctcgtgtttg gcccctcgta gcccgtcacg cccaacggac atccgtcagg
    22801 ttggggcgat accgtgcaca agccgtcgcc atcgaagcca aacaagtcgg tattagatga
    22861 cagctgcaaa ctgctaactg ggcgactcga gttattgacc actccggtca aggtgtcgtc
    22921 agcgccgtcg tacggacctt ggctggcgtc gttgtagatg ttggtctgcc cgtccgccac
    22981 ttggatcaag accccgcaac tggtgtccag tccaatggcc gggcactccg tgaacggcac
    23041 accaggcgcg gccacagccc gaggcgccac caacggtcga gcctgagccg agcccgagaa
    23101 ggtcgcggag gcgtggagcg gatgcgagcc tgggaccggc cggtcgggtc cagcgccagg
    23161 cgcggtctgg gtagccgtcg acctcgttgt cgagggtgca ggagccggct cggtcgatgt
    23221 cgcggtcgtc gggggcacgg ccgccgaggg cggactgctc gtggttgtcg gcgaatcgct
    23281 cggagcaccg ctggccggta gttgagcggc caaaacgatt gcgcatgtcg ccacaacact
    23341 gcctgcgaac aaccgagcgc gcacgggagc ctccaagcgc cgaggatgcg cccaaccgag
    23401 cacaccggtg cctccacgtc gctgaagcgg ctacggtcgt tatacggctc gtccaagaag
    23461 accataattg gctagatatt gtctcttttc aggggaacgc aagcctcgaa tggcggcggg
    23521 tcgacagtcc caaatggaac ggtcgagtca ttagtggacg aacggcttga ggaaccgtgc
    23581 gtcagtaggt gcctaaatgg ccgtatccga tagcaaccaa ccgacccgtc acgcagccag
    23641 ttaccagctc cccgggatgt ttcagtcgat gatccgccag gtgcgctcct gcccgacggt
    23701 accgtcggcc gtagctcctc gtagccggtt ctagatatag ccggtccgac cagtcctgct
    23761 gggcggaagc gtggcagtgc gggcacacga accgacgctt ctccacagca ggagcgcgat
    23821 tcgccggcgc tcaccgagtc cgactagttg gacggagttc tcgcctacca ggccggtcga
    23881 ctccggtcgt ggtgaggtag gaaacggcgc cgacgatcgc catggcgagc accaggctga
    23941 tccagccgct gccgacgccg accccgcctg cgtcggtcgg cttgcccagc cagtcggcgg
    24001 gggacgcgcc gagtgggcgg gtgagcacgt aggcggccca gaaactgagg atcgggttcc
    24061 aattcagcca ccggaaacct gccgcgggca ccatgatcag cccggcgtac aacgcgatcg
    24121 agacgaggta acccaggttc agcgtcacgg ccgtcaggtc gcccacggcc gtgcccagcg
    24181 cgaaggttgc cacgacggcc gcccagtaga acccctcgcg gcgccacgag tcgatggcgt
    24241 ggatagacaa ggtcttctcg gtccgctgcc agatgacgaa cacagcggcg aggacgacgg
    24301 cgtagagagt ggctgacgcg aaatagggca caccgaaccc gacatgcagg acatccgcgg
    24361 ccattgtccc gaaaatgccg accatcacca cggccgtcca gtacgccggg gcggcatagc
    24421 ggcgcatcga gaactggacg atcagagcgg cgacgaaagc caagaaaccc agtgctacgg
    24481 cgatgacggg gctcagcgcc cggaccatgt agtccgacgc cgactcgccg agcgcggtcg
    24541 acaatccttt gatgatccag aagtacgcgg ttatctccgg tacgcgcaga gtgcgcgtca
    24601 ccgtaggcgc cgacagggca gagctgctca tcatgcaaat atccttcggg tgtgaacgtg
    24661 cgagttacga cggacggaca attcctgtgt cgtatgcgaa aatgaccatt tgcacgcggt
    24721 cgcgtagttc gagtttgtgc aggatccggc cgatgtgggt cttcacggtc gcctcggaca
    24781 cctgcagctt gccggcgatc tcggcgttgg ccagcccgcc cgccacggac tcgaggacct
    24841 cccgctcgcg gtcggtcagc cgcgccaggt cctggtgcac cggcgccgcg gcttcgggca
    24901 gatggtgcac cacggtgtcc agcagccgcc gggtgatgcg cggcgccatc accgcgtccc
    24961 cgtcggcgac ggcgcggatc ccggccagca gctcttcggg cgggcagtcc ttgagcagga
    25021 acccgctggc cccggcgcgc agggcggcga acacgtactc gtcaagcccg aacgtggtca
    25081 ggataaccac gcggcaggac ggcaacacgg tgacgagttc gcggcaggcc tcgataccgt
    25141 ccatgccggg catgcggatg tccgtgagca cgacgtcggg ccgcagttcg agcgccgctg
    25201 cgaccgcccg cccgccgtcc gctgcctcgc cgaccacctg caggtccggc tgcgagttga
    25261 gcaccatggc gaaacccatg cgcagcaacg gctggtcgtc ggcgagcagg atgcggacag
    25321 tcacggcgcc ggctccgcga agtcgagcac ggcgtgcacc cgccagccac cgtcaggacc
    25381 cgacccggcg tcgagctcgc cgccgaacaa cgccgcgcgt tcccgcatcc cggtcagccc
    25441 gtgcccgggg ttgccggtgc cgccgtggcc gtcgtccacg acttccaggt tcagccgtcg
    25501 gtcctgccag gacaacgtga ccgtggccgt cgcgcccggg ccggcgtggc ggaccacgtt
    25561 cgtcagtgct tcctgcacca gccggtagat ggtgagctgc gcgctcgccg cgagctgcgg
    25621 cgccttgccg acgaccacga accgagtcgg caagccggcg agtcgaacgg cagcgag
//
