LOCUS       NZ_SNXZ01000002        22586 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Labedaea rhizosphaerae strain DSM 45361 Ga0310470_102, whole genome
            shotgun sequence.
ACCESSION   NZ_SNXZ01000002
VERSION     NZ_SNXZ01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Labedaea rhizosphaerae
  ORGANISM  Labedaea rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Labedaea.
REFERENCE   1  (bases 1 to 1608339)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1608339)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004362825.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 13:11:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,753
            Genes (coding)                    :: 7,690
            CDSs (with protein)               :: 7,690
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 11 of 63
            Pseudo Genes (incomplete)         :: 55 of 63
            Pseudo Genes (internal stop)      :: 3 of 63
            Pseudo Genes (multiple problems)  :: 6 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:41:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 81593
            Orig. end                         :: 104179
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SNXZ01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22586
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22586
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22586
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12586](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12586)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(726..1700)
                     /locus_tag="EV186_RS10015"
                     /old_locus_tag="EV186_10281"
     CDS             complement(726..1700)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334515.1"
                     /locus_tag="EV186_RS10015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10281"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_133848963.1"
                     /transl_table=11
                     /translation="MELTELLSKARAGDGEAFRALVQPHRTELLVHCYRMLGSLQDAED
                     ALQDTLLDAWRAIGGFEQRSSIRTWLYRIATNRCLNARRASSRRQAKEWSIPQVDPPEP
                     TRLGEVVWLEPFPDALLDVPLGPEARFEQAESISLAFITALQTLPPRQVAVLVLRDVLG
                     FHADEVADMLDATVDSVTSALKRARATLARQPTPSRVAEDAVVARFARAWEAADLDALV
                     DLLTDDVFISMPPVPFEYVGREPAAAFCGRIFGAGRRFDLVPTRANGQPAFGAYLRGAD
                     GIGHGTGLYVLTLAGARISAMTAFEKGVLTRFGLPRSLPVSQR"
     gene            1814..2404
                     /locus_tag="EV186_RS10020"
                     /old_locus_tag="EV186_10282"
     CDS             1814..2404
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641428.1"
                     /locus_tag="EV186_RS10020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10282"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_133848964.1"
                     /transl_table=11
                     /translation="MGKIVAFENVSLDGTTQDATGEEGFCSTDWRDTLAPADREAWSKL
                     ILEDALGARALLMGRRSYEFFATRYPSRTSPLADAMNSMPKYVVSSTLEDPGWANSTVL
                     RGDPMTEVTKLKEAVDGEIRVYASAHLLHTLLDHDLVDELRLAVFPLLMGGGARFFDQQ
                     SNPKPLHPKQLRLVESRTVGDALLHLTYRPAPR"
     gene            complement(2412..4316)
                     /locus_tag="EV186_RS10025"
                     /old_locus_tag="EV186_10283"
     CDS             complement(2412..4316)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF008559.0"
                     /locus_tag="EV186_RS10025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10283"
                     /product="primary-amine oxidase"
                     /protein_id="WP_133848965.1"
                     /transl_table=11
                     /translation="MNNPLEPLTADEIAATSAILKGAKGLGATVRFLSVELHEPSKRAV
                     LDGVAAEREAFVVLRDRDSRTTIEAVVSLSRAELVSWREVPLAQPGFSRDEFAAADEVL
                     RGDPAFREALQRRGITDLDAVAIDLWAAGNTGPAEDPARRLMRPQFYVRQGRFDNRYAH
                     PIEGLTALVDIDRMEVVELVDHGVVAVPPRHGNYIPELVTGEIDGYPDNVPAFAAVRDD
                     LRPVEITQPHGPSFTIDDHELRWQKWRMNIGYTMREGLVLHQVGYVDDGRVRPILYRAS
                     MSELYVPYGDPNPSQRVKNAFDIGEGGIGPWLNSLALGCDCLGEIRYLDVVMCDDDGAP
                     VTLPNAICIHEEDDNIVWKHTDGNLGHVETRRQRRLVVSCWATANNYDYGFFWYFYVDG
                     TIEFEVKLTGIVSTGAFEGDEPAFGTALAPGLYAPNHQHFFNMRLDMTVDGERNSVYEV
                     DTVAVPGTAHHNAFAARPRLLARESEAQRIVDPLAGRYWTVVNPSVRHHTGRPVGYKLA
                     PGENILPLAQDGSQTSRRAGFAYRHLWVTAYDPAQRYASGDYPNQRPHDDGLAVYAQAD
                     RPLEDTDVVVWYTFGANHVPRPEDWPVMPVSKVGFHLKPVAFFAANPALDLPRPGHHC"
     gene            complement(4317..4460)
                     /locus_tag="EV186_RS39865"
                     /old_locus_tag="EV186_10284"
     CDS             complement(4317..4460)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS39865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_10284"
                     /product="hypothetical protein"
                     /protein_id="WP_166659100.1"
                     /transl_table=11
                     /translation="MTTDLVDPVHEVEILAAREPEPDRLESSPLYGFPLGHWDYAHRID
                     EV"
     gene            complement(4460..6163)
                     /locus_tag="EV186_RS10030"
                     /old_locus_tag="EV186_10285"
     CDS             complement(4460..6163)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075999.1"
                     /locus_tag="EV186_RS10030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10285"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_133848966.1"
                     /transl_table=11
                     /translation="MKREIAFGVAAMPRKPAVALLLWSVPEALPASLSGLAVAHAVDSG
                     FLADRPAVGLGWLALLLVAAGLGAIGSRQVYRLLGGLVEPFRDLLVRKVVGGALGHAVR
                     GKADDGAIARLTHQVEIVRDTYAGLIVVLRGFLVTVIGVVIGMLSVDPVIVALLLPPFL
                     LGLGAFLATLGMAADRFRRSVRADEQLAVTAGAVLAGTRDIAATGAEEHAAAMTKGPIE
                     AQADAERAIATVAAVRSLCLALGGWVPLVVLLVAGPWLVSRGLTAGAVMGGLTYVLIGL
                     QPVLRNLMTAVGGSGLRYAVTLGRILDAAELPSEPEPRAHAGQGDELAVRGLTFAYGPH
                     AEPVLRDLDLVVPPGDHLAIVGPSGIGKSTLAGLLCGLLRPGEGAVLLGGVPVADLPAD
                     QLARGRTLIPQEAYVFAGGVWDNLTYLAPDADPERVAHAITAVGADALVARIGGVGATL
                     VPAELSAGERQQVALVRAYLSPAPVVVLDEATCHLDPVAERRAEEAFAERGGTLIVIAH
                     RVSSALRARRVLVLDGTGAAVGDHRTLQETSPLYRDLLGHWNPDRRLEEV"
     gene            complement(6160..7806)
                     /locus_tag="EV186_RS10035"
                     /old_locus_tag="EV186_10286"
     CDS             complement(6160..7806)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076000.1"
                     /locus_tag="EV186_RS10035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10286"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_133848967.1"
                     /transl_table=11
                     /translation="MITFGDVVRRGGGWLPLIGLAGLVGSLGTLALPTVLGHAVDALVA
                     GHGSGSWIVAAGVLIVISVVFDVVDAYAGTACVAGTTAWLRDRVVRHVFAVGPARSSRF
                     ETGDLVTRVSGNAVEAAQAGPAVVTTVAAALPPVGSLVLLAWIDPWLALALLAGLALVA
                     GVLRTFALRSAEAMVAYQQTQGTIAARLAESLAGARTIAAAGTVEAEQQRVLTELPRLH
                     EHGIGTWRIMARSSAQATLVGPLVLVAVLATGGIELLRNRITPGELFAASQYAVIGGGL
                     GALTGVFSRLARAKAGVRRVSEVLDTTPVSYGTASLPDGPGALELRSVTVRAADAVLLD
                     DVSLQVPGGCAVAVVGASGAGKSVLAEVAARLRSPDEGEVLLDGVALAELDHAALRAAV
                     GCAFERPVLVGASIGDAVDVGRSVDVRAAARATHAHEFVSRLPEGYATPLAEAPMSGGE
                     YQRLGLARAWPAQRLLVLDDATSSVDMVTEMQIARTLTDDHGGRTRLIVTHRAATAARA
                     DLVVWLAEGKVVATGTHDRLWERPEYREVFG"
     gene            complement(7803..9794)
                     /locus_tag="EV186_RS10040"
                     /old_locus_tag="EV186_10287"
     CDS             complement(7803..9794)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076002.1"
                     /locus_tag="EV186_RS10040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10287"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_133848968.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 7.6e-54, bitscore:
                     178.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPQRLAKPEDLAERQPIVDELHGHRVPDPYRWLEDATSEQTRRW
                     LDAEDERWRTHAAALPGRERLHHEVARLSATGVVTAPVWRGGRQFFLRQEPGQEHPVLH
                     VSDSDGADGADGAARRLVDPASFDSDGLVALDAWQPSLDGTRLAFQISHGGTENSVLHV
                     LDVESGAVLDGPVHGCRYSPVAWFPGAEFFCYVRERRVWRHRVGTPVEQDVALLDRTGS
                     FGLDLSEDGRWLVIAEGTGLWLADLVAGGVATVHEGPDSRAVAMVHDGLLYVFTDHGAP
                     RGRVCVADPSTPSHWRELIPEDPEAVISDLAVLDDPRPMLLVSRIRHAVGEMSLHALAT
                     GARIGDVPLPGAGSLGSVSTSGHEAWFSYTDSVTPGAVYRYDAALHRTTLWAGTPGVDV
                     PEVTSRQLTATSPDGTPIRVVVLAKPGTGPRPTILYGYGGFGVPLTPSYSSYILAWVEA
                     GGVFASAQVRGGGEEGEQWHRDGMLDRKQNVFDDFVAVAEHLIAERWTTPSRLGICGES
                     NGGLLVAGALTQRPELFAAAVCSAPVLDMVRYEQFGLGPQWREEYGTAADPEQLAWLLG
                     YSPYHRVREGVAYPAVLFTTFGGDTRVDPMHARKMCAALQWASTSGRPVLLRHEPDVGH
                     GASPATRAVALAGDMLAFLATHTGLDVA"
     gene            complement(9867..9995)
                     /locus_tag="EV186_RS10045"
                     /old_locus_tag="EV186_10288"
     CDS             complement(9867..9995)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027060.1"
                     /locus_tag="EV186_RS10045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10288"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_133848969.1"
                     /transl_table=11
                     /translation="MALLDLQGLEAPGGKGGGGGSTLTVLGCASQTPSNISLALCH"
     CDS_motif       complement(9933..9995)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGLEAPGGKGGGGGS"
                     /locus_tag="EV186_RS10045_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9867..9932)
                     /prepeptide="core"
                     /locus_tag="EV186_RS10045_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="8.30"
                     /molecular_weight="2021.3"
                     /monoisotopic_mass="2020.1"
                     /core_sequence="TLTVLGCASQTPSNISLALCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGLEAPGGKGGGGGS"
                     /leader_location="[9932:9995](-)"
                     /alternative_weights="2039.4"
                     /alternative_weights="2057.4"
                     /alternative_weights="2075.4"
                     /alternative_weights="2093.4"
     gene            complement(10001..12586)
                     /gene="lanKC"
                     /locus_tag="EV186_RS10050"
                     /old_locus_tag="EV186_10289"
     CDS             complement(10001..12586)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="EV186_RS10050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10289"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_133848970.1"
                     /sec_met_domain="micKC (E-value: 2.1e-246, bitscore: 816.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 4.5e-15, bitscore: 52.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.2e-09, bitscore:
                     33.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVNDEAGYEVYCLADRLFYDKPTRHPSEDTDFPVTGRTVPHGWA
                     HEPSDTWMYYAPSDAVVPTQGWKIHVSSCLADAERVLETVWDFCVARGLPFKYLRSRNV
                     AVMFNAKSAFRGSSGKLATIYPLSDERFEAVLAELDALLRGVVGPYILSDLRYGDGPLY
                     VRYGGFTERFCVAGNGERVLAIEDADGTLVPDVRGPTFALPPWIPLPAFLEPHLAARAA
                     VTTTDLPYTIESAMQFSNGGGVYLGRDNRSGERVVLKEGRPHAGLDVAGRDAVTRIGHE
                     YDVLTRLAGLDVVPAVLDRFELGEHHFLVEEFVDGNPLQRLLVHRYPLTHPDPSPEELA
                     EYVDWALGMLGKVASAVDALHGRGVVFNDLHPENILVTAEGRLALIDFEVATLVEDHAR
                     STLAHPAFTAPADRLGVDVDRYALACMYLGMFAPQATITAPFDPGKARQIAEYAAEVFP
                     LPPGALDEAVRTIEGDAPAKPSRMAELPLPGVSTWDDVRAALRTSILAAATPDRDDRLF
                     PGDVAQFLPGGGIGIAHGASGVLYALAATGAGRFPEHEDWLRKHALAPADNTPAGFYNG
                     LHGVAYVLAELGHHQDALQLVERCLAMPVDATELGLHNGLAGMGLNLLHFRDDVGIEPA
                     MRAVDQVADRLGGVTDMPEISGGDHPRAGLMFGSSGPALLFLHAYEQTGDSNLLDRAEV
                     ALRQDLRRCMRPEDGTLQVDQGWRTLPYLDEGSVGIALVLARYLAHRADDELAEALTRL
                     RGVTRSSYFVQSGLYTGRAGMLLCAEPSAVDMLVRGLCWHAVPYGDGLAFPGNQLLRLS
                     MDFATGTAGVLFALGAVLHDEPVRLPFLADPKNPDAPRHSFSDDHSKEV"
     misc_feature    complement(12305..12307)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12823..15876
                     /locus_tag="EV186_RS10055"
                     /old_locus_tag="EV186_10290"
     CDS             12823..15876
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="EV186_RS10055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10290"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_133848971.1"
                     /transl_table=11
                     /translation="MGMRCTHSSTDALIEATTRHRILAVTAVAGWGKTTAVALWARAWR
                     AIWVTAPEADADSADWLSSEVPAVGAQGNDVDDVVLVVDDLHHVRPGTPSARYLEDLCL
                     RPPAGLRIVLVSRVDLPFAKDALQRKGFLGEVGAPELALDLAAVVDLLRTTIGQDPPAI
                     AARLWAATGGWPVAVRHALDLLQGVEPERRLAVLAGLTRPGTTFHRYLATQVVGQEDPD
                     TQELLRQLANGEEGDVPLDGVARRGLLWPKAGAVPHWQLLPPLARYFERDEVLTVPSRT
                     RLHRALRRLIAAGDHHACAELLAEHGDELVTGGHAEAVLEALALPESPPEDARLHQILG
                     TALQVRGEMRAAEDRLRRAAGEQTELSAELGWRMCALAFAKGELHELLGLVERVRFDAG
                     DVTDAASSLAQLRTLYFAACAHRSTGDAHGLKLTVDRVLRLREQCPEQAAETAEMMVRH
                     VQAMQCTVEANRRAADAHGAAAVAAAEQAGNRLAVGWLRACQASALLEQGAPGPAKAEA
                     DAVLRLAERLETPFLIALALTLRGRAQLRLGALDRARADLTAAAETFEDLGSRFLAWPL
                     CGLGDLHRSRGQLVRARLAYEEALELAEPGHEVLGLGAALIGLARIRAADDPAVARAYA
                     DRAVGLGEPLRMVPAHLARGWVALLDGDREGAAADAAQAAAQARQRHDQTGLAEAVSLT
                     VLAAPDPATDSGMLREAIEIWRETGCRPEGAAAGLVAASVGVTVPGLSADEAAATLRAC
                     GLDPAVRRGAGSLAALTEAPRTVAVHALGVFRVIRNGAAVPRTAWQSRKARDLLKILVS
                     RGRPVPRDQLMEHLWPDVDPTKSGNRLSVLLSTVRDVLQPVEGGPQPLATDGTAVWLDS
                     ALVSVDVEEFRKVATRALDAHRSNHPDAVDRLCTAASMYTGDFLEDDPYADWAQHVTEE
                     LRALHQAVLRALIDHRQARGDIDEVVRHTLRLLEDDPYDEQAHLNLVTVLLAAGRIGEA
                     HRRHEIYRRHMAEMGIEPRPMPATRGRG"
     misc_feature    13180..13182
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15873..16586)
                     /locus_tag="EV186_RS10060"
                     /old_locus_tag="EV186_10291"
     CDS             complement(15873..16586)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223216.1"
                     /locus_tag="EV186_RS10060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10291"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_133848972.1"
                     /transl_table=11
                     /translation="MEFTGVKALVTGANRGLGKQFVDGLLARGAEVYAAARNPATIERR
                     PGVTPLRLDLTDPASVEEAVEQAGDITLLINNAGVAGGTSLLTGDLTAAHADFDTNFWG
                     TLRVTRAFAGPIEGNGGGTILNVLSVLSWVSLPGSGAYSASKAAAWSMTNALRVELAEK
                     KISVAALHVGYMDTDMAAHIDPSGQTDPALVAGLALDGIAAGEHEIIADELSRQVQGGL
                     SGGVAALYPQLSSVD"
     misc_feature    16627..16639
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            16660..17124
                     /locus_tag="EV186_RS10065"
                     /old_locus_tag="EV186_10292"
     CDS             16660..17124
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013678283.1"
                     /locus_tag="EV186_RS10065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10292"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_133848973.1"
                     /transl_table=11
                     /translation="MRNTSPAQSTCAIARTLAALNDRWSFLVLREAFSGVTKFGEFREN
                     LGIASDVLSARLATLVDYGILTKERYQEPGQRARDAYLLTPAGTDLKVVLGALQQWGDN
                     HLARPEGPSIHRVDATTGAPLNVVFADDQGHVVDKDEAAFVRTAAYPSGD"
     gene            complement(17258..17686)
                     /locus_tag="EV186_RS10070"
                     /old_locus_tag="EV186_10293"
     CDS             complement(17258..17686)
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="EV186_RS10070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10293"
                     /product="ATP-binding protein"
                     /protein_id="WP_166659101.1"
                     /transl_table=11
                     /translation="MTTKRSEEDVTSTPEELHCRVEADANRLAAVRKALSGWAEDLGMT
                     REQRSDLVLAAYEALANAAEHAYVGRTDGVIDLSARCTQGTITIVVTDYGTWRAPQPSD
                     GLRGRGLLLINALTRHHQVTHGDNGTTVTMTWPTPGSG"
     gene            complement(17683..19368)
                     /locus_tag="EV186_RS10075"
                     /old_locus_tag="EV186_10294"
     CDS             complement(17683..19368)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640136.1"
                     /locus_tag="EV186_RS10075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10294"
                     /product="GAF domain-containing SpoIIE family protein
                     phosphatase"
                     /protein_id="WP_243753951.1"
                     /transl_table=11
                     /translation="MATETPAAIMDALVAALTDEHGIALAHEVCVYTGQVDGELTPSGT
                     GVVDPARLGRLVTARWAELTGVRHDVLVVDGDELRPGAGGHALVLSTCTAAGAVLCVVA
                     LGGADLAAHGAALLAPVLAGIRLWDQVVGTEARALAETVRELRAEAGLVDTLHAVGARL
                     TAQLDIDRVVQDATDAATAATGAAFGAFFYNLIDQYGESYTLYTLSGVPREAFSRFPMP
                     RNTAVFAPTFDGVGTVRSDDIVADPRFGRNAPYHGMPEGHLPVRSYLAVPAISATSGEV
                     LGGFFFGHPEHGRFTERHQFFAEGIAGYAAIALDNARLFERERNLASELARSMLPVVPD
                     LPHLRIVTRYRPAATGIKVGGDWFDVIALPGGRTAFVIGDAVGHGVTAAAVMGQARTAI
                     RSYAQLDLAPSALLRNVSQLIGSVSATGTFVTCFYAVHDPVDDCLTYANAGHLPAVLVH
                     TDGTQEQIGEAMAQPLGVGEEFPQRQAAFPPGADVVLYTDGLVESRTRDLDEGIRNLLS
                     GLETVRTADDTAAACDSLIAQLTGGQHDDDIALIHVHHQDGGAS"
     misc_feature    complement(18013..18015)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19368..19784)
                     /locus_tag="EV186_RS10080"
                     /old_locus_tag="EV186_10295"
     CDS             complement(19368..19784)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227685.1"
                     /locus_tag="EV186_RS10080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10295"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_133848975.1"
                     /transl_table=11
                     /translation="MDAGTGDDSDTVAKEPGATEPGETEIATETGTIALERQDDRVVVR
                     VTGALDLALAPRLQQFVDRAARLHPALLVLDLTEVDFLASAGMAVLVKANRNQVAPTQM
                     RVVAADRVVLRPLQMTRLTDELAVYPTLAEAFAG"
     gene            19952..21082
                     /locus_tag="EV186_RS10085"
                     /old_locus_tag="EV186_10296"
     CDS             19952..21082
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675711.1"
                     /locus_tag="EV186_RS10085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10296"
                     /product="DUF3500 domain-containing protein"
                     /protein_id="WP_243753952.1"
                     /transl_table=11
                     /translation="MTTRRETAAAMVEAARAWLDLLSDEQRAIGQGPMPADDAGDAERR
                     RWFYTPTDHGGLTMHQQRPAQQRAAMRLVATGLSEAGYVTVTTTMGLENVLDRTEGFVA
                     RFDRERGRDPGLYYLRVFGEPGDDGAWGWRFGGHHVSLNNLVVDGALVSTTPCFMGADP
                     AVSPLLGGAVLRPLARVEDLARELVRSLPAELARRAVLLAKAPSDLVTANRTTVSDGDR
                     VIPLAGIWRGRFRDDAEQARLQAASDAIDEAAGFTDGDHRVVEYTSAPKGVPGSDLDAG
                     QRELLRALLATYFDRVPDSASPLTTYDDEALDGVHVAWCGSLTPGEPHYYRVQGPRLLV
                     EWDNTQRDANHAHSVWRDPQADFGLDVLARHRAAHH"
     gene            21104..21466
                     /locus_tag="EV186_RS10090"
                     /old_locus_tag="EV186_10297"
     CDS             21104..21466
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV186_RS10090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV186_10297"
                     /product="hypothetical protein"
                     /protein_id="WP_133848976.1"
                     /transl_table=11
                     /translation="MNTYRVNPDGVAHARSLIDAKQYVLASRWSDVQPSADQQNDFLER
                     HDWAEYGAWHLALTDGAAEDTKARYAFVFGDFRRLHRMGLISCHYRAAEWGHKEVELAA
                     HELLQYLDNSRSGPLR"
     gene            21486..22436
                     /locus_tag="EV186_RS10095"
                     /old_locus_tag="EV186_10298"
     CDS             21486..22436
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675804.1"
                     /locus_tag="EV186_RS10095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_10298"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_133848977.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.9e-54, bitscore:
                     179.6, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKCVVLDDYQGVALSSADWSVLGDDVELVVFDRHLEGEDAVAD
                     ALADAEIVVIMRERTPFPASLLARLPKLELLVTSGMRNGSVDLVAAQRQGVTVCGTAST
                     STAPGELTWALILGLARHLVTENAGMRANGPWQRTVGTDLAGRTLGLLGYGKIGQKVAA
                     VGRGFDMDVVAWSPNLTEDRTVGARLAGSLHELAEVSDVLSIHLVLAGSTRGLVGADVL
                     GRMKRSALLINTSRAGVVDQDALIAALRDERIAGAGLDVFDTEPLPADHPFRTLPNVLA
                     TPHLGYVTRGNYTTYFGQIVEDIAAFLAGQPIRTL"
ORIGIN
        1 cccgcgctcc aggcggccga ccaggacggc aaaccgcagc cgtgggtgta ccgccagggc
       61 gacaaggtgg tggtgaacgt gcccgtgttc agcggcgccg acccgacgca cgtcgacctg
      121 gggctgctct ccgacaccgg cagcaccacg ctgctgcgcg acggcaagcc ggtggacacc
      181 agcgacgtgc ccggcatcgg ccagttcgac gtccccgccg ccaagggtga ctacaagctg
      241 gtcgtcgacg gcacccgcac cgcgacgagc tggccgttgt cgccgaaggt gcacgccgag
      301 tggaccttcg gctcggcgag cacgcgcccg gaccggcgca gcgcggtgga cctgctggac
      361 ctcgggttcg gcctgccgct ggaccggttc gacgcggcgc cggccgctgg cccggtcaac
      421 ggccgcgtcg tcgtgaccca ccaggacggc gccgcgcagc cgggcatcag gcaggtcacc
      481 gtcgacgtct cctacgacga cggcgggacc tggcggccgg ccaccgtcgc ccggcacggc
      541 ggccagtgga cggtcagcat cccggcgggc ggcagcgcgg gcggcttcgc caccgtgcgg
      601 gcgagcgcca ccgacacccg gggcaacacc gtgtcggaga cgctcacccg cgcgtacgcg
      661 ttgagttagg cgcttcgcgg gccgtgcgtc gcctccgtgg cgcacggccc gcaccggcgt
      721 cgcggtcagc gctggctgac cggcagcgac cgcggcaggc cgaagcgcgt caacacgccc
      781 ttctcgaacg cggtcatggc gctgatccgc gcaccggcga gcgtgagcac gtacaacccg
      841 gtcccgtggc cgatgccgtc ggcaccacgc aggtaggccc cgaacgccgg ttgcccgttg
      901 gcccgggtcg gcaccaggtc gaaccggcgc ccggcgccga aaatgcggcc gcagaacgcg
      961 gcggccggct cccggcccac gtactcgaag ggcaccggcg gcatcgagat gaagacgtcg
     1021 tcggtcagca ggtccaccag ggcgtcgagg tccgcggctt cccaggcccg ggcgaaccgc
     1081 gccaccaccg catcctcggc gacccggctc ggcgtcggct gccgggccag cgtcgcgcgg
     1141 gcccgtttga gggcgctggt caccgagtcg accgtggcgt caagcatgtc ggcgacctcg
     1201 tcggcgtgga agccgagcac gtcacgcagc accagcaccg cgacctggcg cggcggcaac
     1261 gtctgcaacg cggtgatgaa cgccagcgag atcgactcgg cctgctcgaa ccgggcttcc
     1321 gggccgagcg gtacgtcgag cagggcgtcc gggaacggtt ccagccagac gacctcgccg
     1381 agccgggtcg gctccggcgg gtcgacctgc gggatgctcc actccttggc ctggcggcgg
     1441 ctcgacgcgc ggcgcgcgtt caggcaccgg ttggtggcga tccggtacag ccacgtgcgg
     1501 atcgaggacc gctgctcgaa cccgccgatg gcccgccacg cgtccagcag ggtgtcctgc
     1561 aaggcgtcct cggcgtcctg cagcgagccg agcatccggt agcagtgcac cagcaactcc
     1621 gtgcggtgcg gctggaccag cgcgcggaac gcctcgccgt cgccggcccg cgccttcgac
     1681 agcagctcag tgagttccat ggtcgcctcc tcacccggta tggacaccgg ccggaccacg
     1741 aactgggcgc ccagttcgcg atcaggccgg tgtctacccg gggtgacagt ttcgaccatg
     1801 gaaggagaag acgatgggca agatcgtcgc cttcgagaac gtgtcgctcg acggcaccac
     1861 ccaggacgcc accggtgagg agggcttctg cagcaccgac tggcgtgaca cgctcgcccc
     1921 ggccgaccgc gaagcctgga gcaagctcat cctcgaggac gcgctcggcg cgcgggcctt
     1981 gctgatgggc aggcgttcct acgagttctt cgccacccgg tatccgtcac gaaccagccc
     2041 gttggcggac gcgatgaaca gcatgcccaa gtacgtcgtc tccagcacgc tcgaggatcc
     2101 cggctgggcc aactcgaccg tgctgcgcgg cgacccgatg accgaggtga ccaagctgaa
     2161 ggaagcggtc gacggcgaga tccgcgtcta cgccagcgcg cacctgctgc acaccttgct
     2221 cgaccacgac ctcgtggacg agctgcggct ggccgtgttc ccgctcctga tgggtggcgg
     2281 tgcccggttc ttcgaccagc aaagcaaccc gaagccgttg caccccaagc aattgcgcct
     2341 ggtcgagagc cgtacggtcg gcgacgccct cctccacctg acctaccggc cggccccacg
     2401 gtgagccctg gtcagcagtg gtggcccggg cgcggcaggt ccagggccgg gttggcggcg
     2461 aagaaggcca ccggtttgag gtggaagccc accttggaca ccggcatcac cggccagtcc
     2521 tccggccgcg gcacgtggtt cgccccgaac gtgtaccaga ccacgacgtc ggtgtcctcg
     2581 agcggtcgat cggcctgggc gtacaccgcg agcccgtcgt cgtgggggcg ctggttgggg
     2641 tagtccccgg aggcgtagcg ctgggcgggg tcgtaggccg tgacccacag gtgccggtag
     2701 gcgaacccgg cccgcctgct ggtctgcgac ccgtcctgcg ccaacgggag gatgttctcc
     2761 cccggcgcca gcttgtaccc gaccgggcgg ccggtgtggt ggcgcacgga cgggttcacc
     2821 accgtccaat agcgaccggc gagcgggtcg acgatccgct gtgcctcgct ctcgcgggcc
     2881 agcaacctgg gccgtgccgc gaaagcgttg tggtgcgcgg taccgggcac ggcgacggtg
     2941 tccacttcgt acacgctgtt gcgctcgccg tcgacggtca tgtccaggcg catgttgaag
     3001 aagtgctggt ggttcggtgc gtacaggccg ggagccagcg cggtgccgaa ggccggttcg
     3061 tcgccctcga acgcgccggt cgacacgatc ccggtcagct tgacctcgaa ctcgatcgtg
     3121 ccgtcgacgt agaagtacca gaagaagccg tagtcgtagt tgttcgccgt cgcccagcag
     3181 gacacgacga ggcgacgctg gcggcgtgtc tccacgtgac cgaggttgcc gtcggtgtgc
     3241 ttccagacga tgttgtcgtc ctcttcgtgg atgcagatgg cgttgggcag cgtgaccggc
     3301 gcgccgtcgt cgtcgcacat cacgacgtcc aggtagcgga tctcgcccag gcagtcgcag
     3361 ccgagcgcga gcgagttcag ccacggcccg atgccgcctt cgccgatgtc gaaggcgttc
     3421 ttcacccgct gcgacgggtt cgggtcgccg tagggcacgt acagctcgga catcgacgcc
     3481 cggtacagga tcggccgcac ccggccgtcg tcgacgtagc cgacctggtg cagcacaagg
     3541 ccttcgcgca tcgtgtagcc gatgttcatg cgccacttct gccagcgcag ctcgtggtcg
     3601 tcgatggtga agctgggccc gtgcggctgg gtgatctcca ccggccgcag gtcgtcgcgc
     3661 acagcggcga acgccggcac gttgtccggg tagccgtcga tctcgccggt gaccaactcc
     3721 gggatgtagt tgccgtgccg cggcggcacc gccacgacgc cgtggtcgac cagctcgacg
     3781 acctccatcc ggtcgatgtc gaccagggcc gtcagcccct cgatggggtg ggcgtagcgg
     3841 ttgtcgaaac gcccttgccg cacgtagaac tgcgggcgca tcagacgccg ggccgggtcc
     3901 tccgccgggc ccgtgttgcc cgcggcccac aggtcgatgg ccaccgcgtc gaggtcggtg
     3961 ataccccgcc gctgcaaggc ttcccggaag gcaggatcgc cgcgaagcac ctcgtcggcc
     4021 gcggcgaact cgtcgcggga gaagcccggc tgcgccagcg ggacctcgcg ccaggacacc
     4081 agttccgccc ggctgagcga gacgacggcc tcgatcgtgg tccggctgtc gcggtcccgc
     4141 agcaccacga acgcttcacg ctcggccgcc accccgtcga gcacggcccg cttcgacggc
     4201 tcgtgcagct cgacgctgag gaagcgtacc gtggcaccga gtcccttggc gcccttgagg
     4261 atcgccgacg tcgccgcgat ctcgtcggcg gtgaggggtt cgagggggtt gttcatttac
     4321 acctcatcga ttcggtgggc gtagtcccag tggccgagcg ggaacccgta cagcggcgaa
     4381 gactccaggc gatcgggctc gggttctcgg gcggcgagga tctccacctc gtgaacaggg
     4441 tcaacgagat cggtcgtcat cacacctcct ccaatctgcg gtcggggttc cagtggccga
     4501 ggagatcccg gtaaagcggg gacgtctcct gcaacgtgcg gtggtcgccg accgctgcgc
     4561 cggtgccgtc gagcaccagc acgcggcgcg cccgcaaggc cgagctcacc cggtgcgcga
     4621 tcacgatcag cgtgccgccg cgttcggcga acgcctcctc ggctcggcgc tcggcgaccg
     4681 gatcgaggtg gcaggtggcc tcgtcgagca ccacgaccgg ggccggcgag aggtaggccc
     4741 gcaccagcgc gacctgctgg cgctcccccg ccgacagctc cgcgggcacc agcgtcgcac
     4801 cgaccccgcc gatgcgggcc accaaggcgt ccgcgccgac ggcggtgatg gcgtgggcca
     4861 cgcgctccgg atcggcgtcc ggcgcgaggt aggtcaggtt gtcccacacg ccgcccgcga
     4921 acacataggc ctcctgcgga atgagggtcc gcccgcgggc gagctggtcg gcgggcaggt
     4981 cggccaccgg cacgccgccg agcagcaccg cgccttcgcc ggggcgcagc agtccgcaga
     5041 gcagaccggc cagggtcgac ttcccgatgc cgctgggccc gacgatggcc aggtgatccc
     5101 ccggcggcac gacgaggtcg aggtcgcgca gcaccggttc ggcgtgcggg ccgtaggcga
     5161 aggtgaggcc acgcacggcg agttcgtcgc cttggccggc gtgcgcgcgg ggttcgggtt
     5221 cggacgggag ttcggcggcg tcgaggatgc gcccgagcgt gacggcgtag cgcaggccgc
     5281 tgccgccgac cgcggtcatg aggttgcgca gcaccggctg gagtccgatg aggacgtagg
     5341 tgagcccgcc catcaccgcg cccgcggtga gcccccggct gaccagccag ggacccgcga
     5401 cgagcaggac gaccagcggc acccagccgc cgagggccag gcagaggctg cgcacggcgg
     5461 cgaccgtggc gatcgcgcgc tcggcgtcgg cctgcgcctc gatcggcccc ttggtcatgg
     5521 ccgcggcgtg ctcctcggcg ccggtggcgg cgatgtcgcg ggttccggcc agcaccgccc
     5581 ccgcggtgac ggccagctgt tcgtcggcgc gcacggaccg gcggaaccgg tcggccgcca
     5641 tccccagcgt ggcgaggaaa gcgccgagcc ccaacaggaa cggcggcagc agcaacgcca
     5701 cgatcaccgg atcgaccgac agcatgccga tgacaacccc gatgaccgtg accaggaatc
     5761 cacgcagcac cacgatgagc ccggcgtagg tgtcccggac gatctcgacc tggtgggtga
     5821 ggcgggcgat ggcgccgtcg tcggccttcc cgcgcacggc atgaccgagc gccccaccga
     5881 cgaccttgcg cacgagcagg tcccggaacg gttcgacgag cccgccgagc agccggtaca
     5941 cctgccgcga cccgatggcg cccaggccgg cggcgacgag caacaacgcc agccagccga
     6001 gcccgacggc cgggcggtcg gcgaggaacc cggagtcgac ggcgtgcgcg acggcgagac
     6061 cggagagcga cgcgggcagc gcttctggca ccgaccagag cagcaacgcc acggccggct
     6121 tgcggggcat ggcggcgacg ccgaaggcga tctcgcgctt cacccgaaca cctcccggta
     6181 ctcgggtcgt tcccacaacc ggtcgtgggt gccggtggcg accaccttgc cttcggccag
     6241 ccacacgacc aggtccgcac gcgccgcggt cgccgcccgg tgggtcacga tcaggcgcgt
     6301 ccggccgccg tggtcgtcgg tgagcgtgcg ggcgatctgc atctcggtga ccatgtccac
     6361 gctggacgtc gcgtcgtcga ggactagcaa gcgctgggcg ggccacgcgc gggcgaggcc
     6421 caggcgctgg tattccccgc ccgacatggg cgcctcggcc aacggcgtcg cgtagccctc
     6481 gggcaggcgc gacacgaact cgtgtgcgtg cgtcgctcgg gccgccgccc gcacgtcgac
     6541 cgaacggccc acgtcgacgg cgtccccgat cgacgcgccg accagcaccg ggcgctcgaa
     6601 cgcacagccg accgccgcgc gcaacgccgc gtgatccagc tccgccaagg caacgccgtc
     6661 gagcagcacc tcgccctcgt ccggcgaacg caaccgcgcg gccacctcgg ccagcaccga
     6721 cttgcccgcg ccggacgccc cgaccacggc aaccgcacac ccgcccggca cctgcaggga
     6781 aacgtcgtcc agcaacaccg cgtcggcggc ccgcacggtc accgaccgca gctccaaggc
     6841 cccgggaccg tccggcaacg aagccgtgcc gtaggagacg ggcgtggtgt cgagcacctc
     6901 gctgacccgc cgcaccccgg ccttggctcg cgccaaacgg ctgaacacac cggtcaacgc
     6961 accgaggccg ccgccgatca ccgcgtactg gctcgccgcg aacagctcac ccggcgtgat
     7021 ccggttgcgc agcaactcga tgccgccggt ggcgagcacg gccaccagca cgagcggacc
     7081 gaccagcgtg gcctgtgcac tcgagcgcgc catgatccgc caggtcccga tgccgtgctc
     7141 gtgcagccgc ggcaactccg tgagcacccg ctgctgctcc gcttcgaccg tcccggcggc
     7201 ggcgatcgtg cgggcccccg cgagcgactc ggccagccgg gccgcgatcg tgccctgcgt
     7261 ctgctggtag gcgaccatcg cctcggcact gcgcaacgcg aaggtccgca acaccccggc
     7321 caccaaagca agtcccgcca gcaaggccag cgcgagccag ggatcgatcc acgccagcaa
     7381 caccaggctg ccgaccggcg gcagcgcggc cgccaccgtg gtcaccacgg ccggtcccgc
     7441 ctgtgcggcc tcgacggcgt tgccggacac gcgcgtcacc aggtcaccgg tctcgaaccg
     7501 gctcgagcgg gccgggccga cggcgaacac gtgccgcacc acccgatccc gcagccacgc
     7561 ggtcgtcccg gccacgcacg ccgtacccgc ataggcgtcg accacgtcga acacgacgct
     7621 gatgacgatc aggaccccgg cggccacgat ccagctgccg ctgccgtgcc cggcgaccag
     7681 ggcgtcgacc gcgtggccca gcacggtggg cagggcaagc gtgccgaggc tgccgaccag
     7741 gccggcgagc ccgatcaggg gcagccagcc accgccacgc cggaccacgt cgccgaaggt
     7801 gatcatgcga cgtccagccc ggtgtgggtg gcgaggaacg ccaacatgtc gcccgccagc
     7861 gcgaccgcgc gggtcgccgg gctcgcgccg tgcccgacgt ccggctcgtg gcggagcaac
     7921 accggccgcc cgctcgtgct cgcccactgc agggccgcgc acatcttgcg ggcgtgcatc
     7981 gggtcgaccc gcgtgtcgcc accgaacgtc gtgaacaaca ccgccgggta cgcgacgccc
     8041 tcgcgcaccc ggtggtacgg cgaatacccc agcagccagg ccagttgttc cggatcggcc
     8101 gccgtcccgt actcctcgcg ccattgcggg ccgaggccga actgctcgta gcgcaccatg
     8161 tcgagcaccg gcgccgagca gaccgcggca gcgaacaact ccggtcgctg ggtcaacgcc
     8221 cccgcgacca gcaggccacc gttggactca ccgcagatgc ccagccgcga cggcgtggtc
     8281 caccgctcgg cgatcaggtg ctcggccacg gccacgaagt cgtcgaagac gttctgcttg
     8341 cggtcgagca tcccgtcgcg gtgccactgc tcgccttcct cgccgccacc acgcacctgc
     8401 gcggaggcga acacgccacc cgcttcgacc caggcgagga tgtaactgga gtacgacggc
     8461 gtgagcggga cgccgaaacc cccgtagccg tagaggatcg tgggtctggg cccggtgccc
     8521 ggcttcgcga gcaccacgac gcggatcggc gtgccgtccg gcgaggtcgc ggtgagctgg
     8581 cggctggtca cctccggcac gtccacgccg ggcgtgcccg cccagagcgt cgtgcggtgc
     8641 agcgcggcgt cgtagcggta caccgcgcca ggggtcacgc tgtcggtgta gctgaaccac
     8701 gcctcgtgcc cgctggtcga caccgatccc agcgaaccgg caccgggcag tggcacgtcg
     8761 ccgatccggg cgccggtggc cagtgcgtgc aggctcatct cgccgacggc gtgccggatc
     8821 cggctcacca ggagcatcgg tcgtgggtcg tcgagcaccg ccaggtcgct gatcaccgcc
     8881 tcggggtcct ctgggatcag ctcgcgccag tgcgacggcg tcgacggatc ggccacgcag
     8941 acgcgccctc gcggcgcccc gtggtcggtg aagacgtaca gcagaccgtc gtgcaccatc
     9001 gcgaccgcgc gactgtccgg tccttcgtgg acggtcgcga cgccgcccgc gacgaggtcg
     9061 gcgagccaca gcccggtgcc ctcggcgatc accagccagc ggccgtcctc gctcaggtcc
     9121 agaccgaacg acccggtgcg gtcgagcaac gcgacatcct gctcgacggg tgtgccgacg
     9181 cggtgccgcc agacccggcg ttcgcgcaca tagcagaaga actcggcgcc ggggaaccag
     9241 gcgaccggcg agtaccggca cccgtggacg ggcccgtcga gcacggcgcc cgactcgacg
     9301 tcgagcacgt gcagcacgga gttctccgtg cccccatggg aaatctggaa cgccagccgc
     9361 gttccgtcga ggctgggctg ccaagcgtcc agcgcgacca gcccgtcgct gtcgaacgag
     9421 gccgggtcga cgagccgacg cgctgcaccg tccgcaccgt ccgcaccgtc cgaatcggac
     9481 acatgaagaa ccgggtgttc ctggcccggt tcctgccgca ggaagaactg ccgtcccccg
     9541 cgccacaccg gtgccgtcac cacgccggtc gcgctcagcc gcgcgacctc gtggtgcagt
     9601 cgttcccggc cgggcaacgc ggcggcgtgg gtgcgccagc gctcgtcctc cgcgtcgagc
     9661 cagcggcggg tctgctcgct ggtcgcgtcc tcgagccacc ggtagggatc gggcacccgg
     9721 tggccgtgca gttcgtcgac gatcggctga cgttcggcga ggtcttcggg tttggcgagt
     9781 cgctgcggcg ccacggccgc tccttccacg ggcgtgggtc ctgggcggtc gcgaggaccg
     9841 cccaggaccc tggaacgtga tcagcctcag tggcagagcg ccaggctgat gttgctcggc
     9901 gtctgggacg cgcagcccag aacagtcagc gtggagccgc caccgccgcc cttgccgcca
     9961 ggagcctcca gaccctgcag gtcgagaagt gccatgtgtg ttacacctcc ttcgagtggt
    10021 cgtcactgaa cgaatgcctt ggggcatccg ggttcttggg gtccgccagg aacggcagcc
    10081 gcacgggttc gtcgtgcagc accgcgccga gcgcgaacag cacgcccgcg gttccggtcg
    10141 cgaagtccat ggacaggcgc agcagctggt ttcccgggaa cgccaggccg tcgccatagg
    10201 gcaccgcgtg ccagcacagc ccgcgcacca acatgtccac ggcggaaggt tcggcgcaca
    10261 gcagcatccc ggcccggccg gtgtagaggc cggactgcac gaagtacgag ctgcgggtca
    10321 ccccacgcaa ccgggtcagc gcctcggcca gctcgtcgtc ggcgcggtgg gccaggtacc
    10381 gggccaggac caaggcgatg ccgaccgagc cctcgtccag gtacggcagc gtgcgccagc
    10441 cctggtcgac ctgcagcgtg ccgtcctcgg ggcgcatgca ccggcggagg tcctggcgca
    10501 gcgccacctc cgcgcggtcg agcaggttcg agtcgccggt ctgctcgtag gcgtgcagga
    10561 agagcagcgc cggtcccgac gagccgaaca tcaacccggc cctcgggtgg tcgccaccgc
    10621 tgatctccgg catgtcggtc acaccgccga gccggtcggc gacctggtcg accgcgcgca
    10681 tggcgggctc gatccccacg tcgtcgcgga agtgcagcag gttcagcccc atgccggcca
    10741 gcccgttgtg caggccgagc tcggtggcgt ccaccggcat ggccaggcag cgctcgacca
    10801 gctgcagcgc gtcctggtgg tgccccagct cggcgagcac gtaggccacg ccgtgcaggc
    10861 cgttgtagaa gccggcgggg gtgttgtcgg ccggggccag cgcgtgtttg cgcagccagt
    10921 cctcgtgttc ggggaagcgg cccgcaccgg tggcggcaag ggcgtacagc acaccggacg
    10981 cgccgtgcgc gatgccgatg ccgccaccgg gcaggaactg cgcgacgtcg ccggggaaca
    11041 ggcggtcgtc gcggtcgggc gtggccgcgg cgaggatcga ggttcgcagc gcggcacgca
    11101 cgtcgtccca ggtggacacg ccgggcaggg gtagttcggc catccggctc ggcttggccg
    11161 gcgcgtcgcc ttcgatggtg cgcacggcct cgtccagcgc accgggcggc aacgggaaga
    11221 cctcggcggc gtattcggcg atctgccggg ccttgccggg gtcgaacggc gccgtgatgg
    11281 tggcctgcgg cgcgaacatg ccgaggtaca tgcaggccag cgcgtaccgg tccacgtcga
    11341 cgccgagccg gtcggccggc gcggtgaacg ccgggtgggc cagcgtcgag cgggcgtggt
    11401 cctcgacgag cgtggccacc tcgaagtcga tcagtgccag ccggccctcg gcggtgacca
    11461 ggatgttctc cgggtgcagg tcgttgaaga cgacgccgcg cccgtgcagc gcgtcgaccg
    11521 ccgaggcgac cttgcccagc atgcccagcg cccagtcgac gtactcggcc agctcctccg
    11581 ggctcggatc ggggtgggtc aacgggtagc ggtgcaccag caggcgctgc agcgggttgc
    11641 cgtcgacgaa ctcctcgacg aggaagtggt gctcccccag ttcgaagcgg tcgagcaccg
    11701 cgggcacgac gtcgagcccg gcaaggcggg tcaggacgtc gtactcgtgc ccgatgcggg
    11761 tcacggcgtc acgcccggcc acgtcgagac ccgcgtgcgg tctgccttcc ttgagcacga
    11821 cccgctcgcc gctgcggttg tcccggccga ggtagacgcc accgccgttg gagaactgca
    11881 tggcgctctc gatggtgtac ggcaggtccg tcgtggtgac cgccgcgcgc gccgccaggt
    11941 gcggctcgag gaaggcgggc agcgggatcc acggcggcag cgcgaaggtc gggccgcgca
    12001 cgtcgggcac gagcgtgccg tcggcgtctt cgatggcgag cacacgctcg ccgttgcccg
    12061 ccacgcagaa ccgttcggtg aagccgccgt accgcacgta caacgggccg tcgccgtagc
    12121 gcaggtcgct gaggatgtag ggcccgacaa ccccgcggag cagcgcgtcc agttccgcca
    12181 gcacggcctc gaagcgctcg tcggaaagtg gataaatagt ggccagcttg ccactcgagc
    12241 cgcggaacgc cgatttcgcg ttgaacatca cggcgacatt tcggctgcgt aggtatttga
    12301 acggtaaacc acgtgccacg cagaagtccc agaccgtctc gagcacccgc tcggcgtcgg
    12361 cgaggcagga cgaaacgtgg atcttccacc cctgtgtcgg caccaccgcg tcactgggtg
    12421 cgtagtacat ccaagtatcg ctcggctcat gcgcccaacc gtgcggaacc gtgcgccccg
    12481 tcaccgggaa atcggtgtct tcactgggat gccgggtcgg cttgtcgtag aacagccgat
    12541 cggcgaggca gtagacctcg tagcccgcct cgtcgttcac cgtcatccgg ttccgcctgt
    12601 tcgcgccgca gtttcgtggt cgctcggaac gttaggaagc gggtgttcca gcagccttag
    12661 cgttgcctta aggccaggtc aagacgaatt aatcgggcca ggctgctcca ttcgtgggac
    12721 gggccgccgt ttgggggaat atcgttctcg ggtggtaaca gatcattttg cgcggccgac
    12781 tggccttgcg ggtcgggcac ccgcttgacg gaggacgcac tcatgggcat gcggtgtacc
    12841 cacagctcca ccgacgcgct catcgaggcc acgacgcggc accggatact cgcggtgacc
    12901 gccgtcgccg gctgggggaa aacgacggcg gtcgcattgt gggcccgcgc gtggcgcgcc
    12961 atttgggtga cggctcccga agcggatgcc gattccgcgg actggttgtc ctcggaagtc
    13021 ccggccgtcg gcgctcaggg aaatgacgtc gatgacgtcg tgttggtggt ggacgacctg
    13081 caccacgtcc ggccgggcac gccgagcgcc cgctacctgg aggacctgtg cctgcgcccg
    13141 cccgccgggc tgcgcatcgt cctcgtgtcc cgcgtggact tacccttcgc caaggatgcc
    13201 ttgcagcgca agggtttcct tggtgaggtc ggcgctccgg agctggccct ggacctggcc
    13261 gctgtcgtag acctattgcg taccacgatc gggcaggacc cgccggcgat cgcggcccgg
    13321 ctctgggccg cgacgggcgg ctggcccgtg gccgtgcggc acgcgctgga cctgttgcag
    13381 ggcgtcgaac ccgaacgacg gctcgccgtg ctggccgggc tcacccggcc tggcacgacg
    13441 ttccaccgct acctggccac gcaggtcgtc ggccaggaag accccgacac ccaggagttg
    13501 ctccgccagc tggccaacgg cgaggaaggc gacgtgcccc tggacggggt ggccaggcgt
    13561 ggcctgctct ggccgaaggc cggtgcggtg ccgcactggc agttgctgcc gccgctggcc
    13621 cggtacttcg agcgcgacga ggtgctgacg gtgccgagcc gtacccggct gcaccgcgcc
    13681 ctgcggcgcc tgatcgccgc cggtgatcac cacgcctgtg ccgagctgct ggccgagcac
    13741 ggcgacgagc tggtgaccgg cggacacgcg gaagcggtgc tcgaagcgct ggcgctgccc
    13801 gaaagcccgc ccgaagatgc acggctgcac cagatcctcg gcaccgcgtt gcaggtccgc
    13861 ggcgagatgc gtgccgccga ggaccggttg cgccgggccg ccggcgagca gaccgagctc
    13921 agcgccgagc tgggctggcg gatgtgcgcg ctcgcgttcg ccaagggcga gttgcacgag
    13981 ctgctcgggc tcgtcgagcg cgtccggttc gacgccggag acgtcacaga cgccgcgagc
    14041 tcccttgcgc agctgcggac gctgtacttc gccgcgtgcg cgcaccgctc gaccggcgac
    14101 gcgcacgggc tgaagctgac cgtcgaccgg gtgctgcggc tccgcgagca gtgcccggag
    14161 caggcggccg aaaccgccga gatgatggtg cgacacgtgc aggcgatgca gtgcaccgtg
    14221 gaggcgaacc ggcgtgcggc cgacgcgcac ggcgccgccg ccgtggccgc cgccgagcag
    14281 gcgggcaacc ggctggccgt gggctggctg cgcgcgtgcc aggcgagcgc gctgctcgaa
    14341 cagggcgcgc ccgggccggc caaggccgag gcggacgccg tcctgcggtt ggccgagcgg
    14401 ctcgagaccc cgttcctcat cgcgcttgcg ctgaccctgc gcggccgggc ccagctgcgg
    14461 ctcggcgcgc tggatcgagc gcgggccgac ctcaccgcgg cggcggagac gttcgaagac
    14521 ctgggttcgc ggttcctggc gtggcccctg tgcgggctcg gcgacctgca ccgctcgcgc
    14581 gggcagctcg tgcgggcgcg cctggcctac gaggaagcac tcgagctggc cgagccggga
    14641 cacgaggtgc tcggcctcgg ggcggcgttg atcgggctcg cgcgcatccg ggccgccgac
    14701 gacccggcgg tggcccgcgc gtacgccgac cgcgcggtcg gcctcggcga gccgctgcgg
    14761 atggtgccgg cccacctggc ccgcggctgg gtcgccttgc ttgacggtga ccgcgaaggc
    14821 gccgcggccg atgcggccca ggcggccgcg caggcccgcc agcgccacga ccagaccggt
    14881 ctggccgagg cggtcagcct gacggtgctc gcggcgccgg acccggccac cgactcgggc
    14941 atgctccgcg aggccatcga gatctggcgg gagaccgggt gccgcccaga aggcgcggcg
    15001 gccggcctgg tcgcggcgag cgtcggcgtg acggtgccgg gtctgtcggc cgacgaggcc
    15061 gcggcgaccc tgcgggcgtg cggcctcgac ccggccgtgc gccgcggcgc cggctcgctc
    15121 gccgcgctga ccgaggcgcc acgcacggtc gcggtgcacg ctcttggcgt cttccgggtg
    15181 atccgcaacg gcgccgccgt gccgcgcacc gcgtggcagt cgcgcaaggc acgcgacctg
    15241 ctgaagatcc tggtgtcccg aggccgcccc gtgccccggg accagttgat ggaacacctc
    15301 tggcccgacg tcgatcccac caagtccggc aaccgcctgt cggtgttgct cagcaccgtg
    15361 cgcgatgtgc tgcagccggt cgagggcggt ccgcagccgc tggccaccga cggcaccgcg
    15421 gtctggctcg actcggcgct ggtgagcgtc gacgtggagg agttccgcaa ggtggcgacg
    15481 cgggcgttgg acgcacaccg ctccaaccac ccggacgccg tcgaccgcct gtgcacggcc
    15541 gcgagcatgt acaccggaga cttcctcgaa gacgacccgt acgccgactg ggcgcagcac
    15601 gtgaccgagg aactgcgcgc gttgcaccag gccgtgctgc gtgcgttgat cgaccaccgg
    15661 caggcccgcg gcgacatcga cgaagtggtc cggcacacct tgcgcctgct cgaggacgac
    15721 ccctacgacg agcaggcgca cctgaacctg gtcaccgtgc tgctggcggc cgggcggatc
    15781 ggggaggcgc accgccggca cgagatctac cggcggcaca tggcggaaat ggggatcgag
    15841 ccccggccga tgcccgcgac ccggggccgc ggctagtcca ctgaggacag ttgcgggtac
    15901 agcgcggcaa cgccaccgga gagaccgccc tggacctgcc tgctgagctc gtcggcgatg
    15961 atctcgtgtt cgccggccgc gatcccgtcc agggccaggc ccgcgacgag cgccgggtcg
    16021 gtctggccgg acggatcgat gtgggcggcc atgtcggtgt ccatgtagcc gacgtgcagg
    16081 gcggccacgg agatcttctt ctcggccagc tcgacgcgca gcgcgttggt catcgaccag
    16141 gccgccgcct tgctcgcgct gtaggcaccg gagcccggca ggctcaccca ggacaggacc
    16201 gacagcacgt tcaggatcgt gccgccgccg ttgccctcga tggggccggc gaacgcgcgc
    16261 gtgacccgca gcgtgcccca gaagttggtg tcgaagtcgg cgtgggcggc cgtgaggtcg
    16321 ccggtgagca gcgatgtccc gccggccacc cccgcgttgt tgatcaggag cgtgatgtca
    16381 ccggcctgct cgaccgcttc ctcgaccgag gctggatcgg tgaggtccag ccggagcggg
    16441 gtgacgccgg ggcggcgctc gatcgtcgcc gggttgcgcg ccgccgcgta gacctcggcg
    16501 ccgcgcgcca gcaggccgtc gacgaactgc ttgcccagcc cgcggttcgc gccggtgacc
    16561 agggccttga cccctgtgaa ctccatgact gcctcctgag ttggtaattc caacctagca
    16621 gctggattgg atatggcaag tcagaggtag gatgaagaga tgaggaacac ctcgccggcg
    16681 cagagcacct gcgccatcgc ccgcacgctg gccgcgctga acgaccggtg gagcttcctc
    16741 gtgctgcgtg aggctttctc gggcgtgacc aagttcgggg agttccgcga gaacctgggc
    16801 atcgcgtcgg acgtgctcag cgcgcggctg gcgaccctcg tcgactacgg gatcctgacc
    16861 aaggagcgct accaggagcc cggccagcgc gcccgggacg cctacttgct gacccccgcg
    16921 ggcaccgacc tgaaggtcgt gctcggcgcg ttgcagcaat ggggcgacaa ccacctggcc
    16981 cgcccggaag gcccgagcat ccaccgcgtc gacgcgacca ccggcgcacc cttgaacgtc
    17041 gtcttcgccg acgaccaagg ccacgtggtc gacaaggacg aggccgcgtt cgtccgcacc
    17101 gccgcctacc ccagcggcga ctgacgcgct cgctgtcggg tacaccgtcg agaaaggttc
    17161 ttcgagcagt cggggcgtgc cgcactgcct ccagtcaggc caaccgctca atccactgtg
    17221 gacggacacc gtggacgggg ctcatgggca gaactgttca gccagagccc ggtgtcggcc
    17281 aggtcatggt gacggtggtt ccgttgtcgc cgtgggtgac ctggtggtgc cgggtcaggg
    17341 cgttgatcag cagcaggcca cggccacgca gcccgtcgct gggctgcggc gctcgccagg
    17401 tgccgtagtc ggtgaccacg atggtgatcg tgccctgcgt gcagcgcgcc gacaggtcga
    17461 tcacgccgtc ggtgcgcccg acgtaggcgt gctcggcggc gttggccagg gcttcgtacg
    17521 cggcgaggac gaggtcggac cgctgttcac gggtcatgcc gaggtcctcg gcccagccgc
    17581 tgagcgcctt gcgcaccgcg gcgagccggt tggcgtcggc ttcgacgcgg cagtgcaact
    17641 cctccggcgt actggtgacg tcctcctcgg accgtttggt cgtcacgagg cgccgccatc
    17701 ctggtggtgc acgtggatga gcgcgatgtc gtcgtcgtgc tgaccgccgg tgagctgcgc
    17761 gatgagcgaa tcgcacgcgg ccgcggtgtc gtcggcggtg cgcacggtct cgagcccgga
    17821 caagaggttc cttatcccct cgtccaggtc gcgggtgcgg ctctcgacga gcccgtcggt
    17881 gtacagcacg acgtccgcgc ccggcgggaa cgccgcctgc cgctgcggga actcctcgcc
    17941 gacgcccagc ggctgcgcca tcgcctcccc gatctgttcc tgtgtgccgt cagtgtgcac
    18001 cagcacggcg ggtaagtggc ccgcattggc gtaggtcaag cagtcgtcga ccgggtcgtg
    18061 cacggcgtag aagcaggtga cgaaggtgcc tgtcgccgag acgctgccga tcaactggga
    18121 cacgttgcgc agcagcgccg acggcgccag gtccagctgg gcgtacgacc ggatcgcggt
    18181 gcgcgcctgc cccatcaccg cggcggcggt caccccgtgc ccgaccgcgt cgccgatgac
    18241 gaacgcggtg cgaccgcccg gcagcgcgat cacgtcgaac cagtcgccgc cgaccttgat
    18301 cccggtcgcg gccggccggt agcgggtgac gatccgcagg tgcgggaggt ccggcacgac
    18361 gggcagcatg ctgcgcgcga gctcgctggc gaggttgcgt tcgcgctcga agagccgcgc
    18421 gttgtccagc gcgatcgccg cgtagcccgc gatcccctcg gcgaagaact ggtgccgctc
    18481 ggtgaaccgg ccgtgttcgg ggtggccgaa gaagaacccg ccgagcacct cgccggacgt
    18541 cgcgctgatc gccggcaccg cgaggtagct gcgcacgggg aggtggcctt cgggcatccc
    18601 gtggtacggc gcgttccggc cgaaccgggg gtcggcgacg atgtcgtcgc tgcgcaccgt
    18661 gccgacgccg tcgaaggtcg gcgcgaacac ggcggtgttg cgtggcatcg ggaaccggga
    18721 gaacgcctcg cggggcacgc cggagagcgt gtagagggtg tacgactcgc cgtactggtc
    18781 gatgaggttg tagaagaagg cgccgaacgc cgcacccgtc gcggcggtgg cggcgtcggt
    18841 ggcatcctgg accacgcggt cgatgtcgag ctgggcggtc aggcgcgcgc ccaccgcgtg
    18901 cagcgtgtcg accaggcccg cctcggcacg caattcgcgc acggtctcgg ccagcgcgcg
    18961 agcctccgtg ccgaccacct gatcccacag ccggatcccg gcgagcaccg gcgccaggag
    19021 cgccgccccg tgcgcggcca ggtcggcacc gccgagcgcc acgacgcaga gcacagcgcc
    19081 cgccgccgtg cacgtggaca ggaccagcgc gtggccaccg gcgccgggcc gcagctcgtc
    19141 accgtccacc accagcacgt cgtgccgcac gccggtcaac tcggcccacc gggcggtcac
    19201 gagccggccc agccgcgccg ggtccacgac gccggtgccc gacggggtca gctcgccgtc
    19261 gacttgtccg gtgtacacgc acacctcgtg cgccaatgcg atgccgtgct cgtcggtgag
    19321 cgcggccacc agcgcatcca tgatggcggc cggggtctcg gtcgccatca gccggcgaac
    19381 gcttcggcca gggtcgggta cacggcgagt tcgtcggtca gccgggtcat ctgcaacggc
    19441 cgcagcacca cccgatcggc cgcgacgacc cgcatctgcg tcggtgccac ctggttccgg
    19501 ttcgccttca ccagcaccgc catcccggcg gaggccagga agtccacttc ggtcaggtcc
    19561 agcacgagca gggccgggtg cagccgcgcc gcgcggtcga cgaactgctg cagcctgggc
    19621 gcgagcgcga ggtcgagcgc gccggtcacc cgcaccacca cgcggtcgtc ctggcgctcg
    19681 agcgcgatcg tcccggtctc ggtcgcgatt tcggtctccc ctggctcggt cgccccgggc
    19741 tccttcgcca cggtgtcgct gtcatcgccc gtccctgcgt ccatgccggc cacgcttccc
    19801 atagtgcctg cctgacaggt cgccaacgac ccgccgcgcg ctaccaccac ccagccgggt
    19861 ggggatcaac gcaacggcgg cgtgtcgcgg cggtcatcgg gaaagcacgc aggtgtggac
    19921 gggaccgggt cggtcggcga cgctggggcg tgtgacgacg cgccgtgaga ccgccgccgc
    19981 gatggtcgag gcggcccgtg cctggctcga cctgctgagc gacgagcagc gggccatcgg
    20041 ccaagggccg atgcctgccg acgacgccgg ggacgccgag cggcggcggt ggttctacac
    20101 gccgaccgac cacggtggcc tcacgatgca ccagcagcga ccggcccagc agcgggccgc
    20161 gatgcggctg gtcgcgaccg ggttgtccga ggcgggttac gtcacggtca ccaccacgat
    20221 gggcctggag aacgtcctcg accggaccga gggtttcgtc gcccgcttcg accgggagcg
    20281 cggccgggac cccgggttgt actacctgcg ggtgttcggc gagcccggcg acgacggcgc
    20341 gtggggctgg cggttcggcg gccaccacgt ctcgctcaac aacctcgtcg tcgacggcgc
    20401 actcgtctcg accaccccgt gcttcatggg cgccgaccca gccgtctcgc cgctgctcgg
    20461 cggggccgtg ctccggccgc tcgcgcgggt cgaggacctc gcccgcgagc tggtgcgctc
    20521 cctgccggcc gagctcgcgc gccgggcggt gctgctggcg aaggcgccgt ccgacctcgt
    20581 caccgccaac cgcacgacgg tgtccgacgg tgaccgggtg atcccgctgg ccggcatctg
    20641 gcgcgggcgg ttccgcgacg acgccgagca ggccaggctg caggccgcga gcgacgccat
    20701 cgacgaggcg gccgggttca ccgacggcga ccaccgggtc gtcgagtaca cctcggcgcc
    20761 gaagggcgtg cccggcagcg acctcgacgc gggccaacgg gagttgctgc gcgccttgct
    20821 ggcgacctac ttcgaccggg tgccggacag cgcctctccc ctaaccacct acgacgacga
    20881 agcgctcgac ggcgtgcatg tcgcctggtg cggatcgctc acgccaggcg agccgcacta
    20941 ctaccgggtg caagggccgc ggctgctcgt cgaatgggac aacacccagc gcgacgccaa
    21001 ccacgcccac tccgtgtggc gcgacccgca ggccgacttc ggactggacg tgctggcgcg
    21061 acaccgggcg gcgcaccact gagcggggga agatgggcac cccatgaaca cctaccgcgt
    21121 gaaccccgac ggcgtggcgc acgcccgctc gctcatcgac gccaagcagt acgtgctcgc
    21181 cagccgctgg agcgacgtgc agccgagtgc cgaccagcag aacgacttcc tcgaacgcca
    21241 cgactgggcc gaatacggcg cctggcacct ggcgctgacc gacggcgcgg ccgaggacac
    21301 caaggcgcgc tacgcgttcg tcttcggcga cttccgccgg ttgcaccgga tgggcctgat
    21361 ctcgtgccac taccgcgcgg ccgagtgggg ccacaaggaa gtcgagctgg ccgcgcacga
    21421 actcctgcag tacctcgaca acagccgcag tgggccactg cgctgaccgc catagggtgg
    21481 ggtctgtggc gaagaagtgc gtggtactgg acgactacca gggcgtcgcg ttgagcagcg
    21541 ccgactggtc ggtgctgggt gatgacgtcg agctcgtcgt gttcgatcgg cacctggagg
    21601 gcgaggacgc ggtagcggac gccctcgccg acgccgagat cgtcgtgatc atgcgcgagc
    21661 gcacgccgtt ccccgcgtcc ctgctcgcgc ggttgcccaa gctggaactg ctggtgacca
    21721 gcgggatgcg caacgggtcg gtcgacctgg tcgctgccca acggcaaggc gtcacggtgt
    21781 gcggcaccgc cagcacgtcg accgcgccag gcgagctgac ctgggcgttg atcctcgggc
    21841 tggcgcgtca cctggtcacc gagaacgccg ggatgcgcgc gaacggaccg tggcagcgca
    21901 ccgtcggcac cgacctcgcg ggccgcacgc tcgggctgct gggctacggc aagatcggcc
    21961 agaaggtcgc cgcggtgggc cgcgggttcg acatggacgt cgtcgcgtgg agcccgaacc
    22021 tcacggagga ccgcaccgtg ggcgcccgcc tcgccggctc gctgcacgag ctggccgagg
    22081 tgagcgacgt cctgtcgatc cacctcgtgc tggccggctc gacccgcggc ctcgtcggcg
    22141 cggacgtgct cggccggatg aagcggtccg cgttgctgat caacacctcc cgcgccggcg
    22201 tcgtcgacca ggacgccttg atcgccgcgc tgcgcgacga gcggatcgcc ggcgccgggc
    22261 tcgacgtgtt cgacaccgag ccgctgcccg ccgaccaccc gttccggacg ctgccgaacg
    22321 tgctggccac cccgcacctc ggctacgtca cccgcggcaa ctacacgacg tacttcggcc
    22381 agatcgtcga agacatcgcc gctttccttg ccgggcaacc gatccggacg ctataggccg
    22441 aacacgtggc gggcgaagcg ctcgccgatg agccggtgcg cctcggtgtc cgggtgcaag
    22501 ccgtccggca gcgcgtggtc ggcctcgccg tagagctcga tgccgctcag gtagcgcagg
    22561 ttctcgtcgt ccgcgcggtt cgcggc
//
