LOCUS       NZ_SNXZ01000001        10435 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Labedaea rhizosphaerae strain DSM 45361 Ga0310470_101, whole genome
            shotgun sequence.
ACCESSION   NZ_SNXZ01000001
VERSION     NZ_SNXZ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Labedaea rhizosphaerae
  ORGANISM  Labedaea rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Labedaea.
REFERENCE   1  (bases 1 to 1988787)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1988787)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004362825.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 13:11:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,753
            Genes (coding)                    :: 7,690
            CDSs (with protein)               :: 7,690
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 11 of 63
            Pseudo Genes (incomplete)         :: 55 of 63
            Pseudo Genes (internal stop)      :: 3 of 63
            Pseudo Genes (multiple problems)  :: 6 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:41:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 667946
            Orig. end                         :: 678381
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SNXZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10435
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10435
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10435
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5435](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5435)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            26..829
                     /locus_tag="EV186_RS02900"
                     /old_locus_tag="EV186_101593"
     CDS             26..829
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669895.1"
                     /locus_tag="EV186_RS02900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101593"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_133847515.1"
                     /transl_table=11
                     /translation="MIESWIAIGDSFTEGVGDEGPDGVCIGWADRLATQLAAVNPSFSY
                     ANLALRGKMMKEILDDQVPIAVAERPDLITLCAGGNDIIVPGVDIDEIAAMFDAAVAAL
                     RATGAQVLVFTAPDVKFQPVVRMVRTKAAIYNAHIHASADRHGAKVVDLWSMSTLRDRR
                     AWSDDRLHFAPDGHRRIALRTAEVLGLPVTEDWREPLPEQPPLRWLDMRRMDVSWARAH
                     LIPWIGRQLRGQSLGDGLAPKRPRLTPYRIPKEPQLQSLKDVTTC"
     misc_feature    complement(51..63)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            complement(988..3804)
                     /locus_tag="EV186_RS02905"
                     /old_locus_tag="EV186_101594"
     CDS             complement(988..3804)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="EV186_RS02905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101594"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_133847516.1"
                     /transl_table=11
                     /translation="MGGRAAAAGGVRFRLLGPIAALVGEDPLPLGGPGTRAVLALLLLN
                     ANQVVPLDRMVDVLWAHEPPATARTIVQGYISRLRKLLAETDPSGSVAIETRPPGYLLV
                     VDESRIDVTWAQRLLARSRGEPARRRAELLREAQRIWRGPALADIKDRVPAPELAELRL
                     AVLEARVDADLELGAHDELVGELAALVDEHPFREHLVRQLILALYRSGRRAAALETYQR
                     FARRAGTERGMDPGPQLRMLHERVLHDDTSLLDIEQPTPRPPMVGVLVPAQLPNTTAGF
                     AGRAAELAWLDEHLSTVDMAATPIAGLIGPAGVGKTALAVRWAHRVARRFPDGQLYASL
                     RGFDVHRAKADPAQLLLRFLLALGVPVGEVPVELDERAALYRSLLADRRMLVVLDDARD
                     SEQVRPLLPGSASALVLVTSRIRLDALVVGSGARMLTLGTLPREDALEVLASTAGPGSD
                     DERADRIRLAQLCGGLPLALRIAGARLAADPQWTAARLADELSGQGQLDVLAAEDNQVS
                     VRAALDATYRALPGRLAATFRLLGLFPGPMLDAYAAAALCGVPVEEAAERLRTMADWSL
                     LVPDGTDGEYHLHDLVRMHAATLARADLYEHQRSEALRRLETYYLAAADQARRFLRPPA
                     DGLDYASDYPKESLAPVTDSESALDWFGSQWANLMSTLDAAAAAEHHVQVWHLARLVHD
                     FRAVRSIRDDWLALLDKGLAAARAANDGVGEVWMLSCRCSARYRLGRLDEMLPDAERSV
                     AIATRLRDPALMAIAFRDVGTALYHQGQHEPAVARLEKALELARRAEFKPVEAALLNNL
                     AQVYRDLARLDDAVAATERAVELYREIGELGFSVFAVANLGELHLERGELDDSERYARA
                     AVDQAVTSALTLQEGFARHVLGKVLLAKGDKAAARSQLVAAARRYADVSQRAAAEVQAD
                     LDRLQPDV"
     misc_feature    3976..3989
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.67"
                     /tool="antismash"
     gene            complement(4102..5004)
                     /gene="thpD"
                     /locus_tag="EV186_RS02910"
                     /old_locus_tag="EV186_101595"
     CDS             complement(4102..5004)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441527.1"
                     /locus_tag="EV186_RS02910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101595"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_133847517.1"
                     /sec_met_domain="PhyH (E-value: 2e-33, bitscore: 113.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAIADTTTEDRYITRITGEPGLIERTDPTVWGHGDGPIDPATLA
                     SHDAKGYSIYEGLLSPGEVQAYRDELTRLATDERLKADERTVVEKASGEVRSIFEVHKI
                     SELIAELVRDPRVLDRARQVLGSEVYVHQSRVNYMPGFKGTGFYWHSDFETWHAEDGMP
                     LPRAVSMSIALTQNYPFNGGLMVMPGSQRSFVQCAGETPADHYKASLKEQEIGVPSQAD
                     ITALAEKYGIDQFTGPAGSALLFDSNIMHGSGNNITPFPRSNIFVVFNSVENTLVEPYA
                     APSPRPTFIASREFEPLRR"
     gene            complement(5001..5435)
                     /locus_tag="EV186_RS02915"
                     /old_locus_tag="EV186_101596"
     CDS             complement(5001..5435)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947387.1"
                     /locus_tag="EV186_RS02915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101596"
                     /product="ectoine synthase"
                     /protein_id="WP_133847518.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.1e-52, bitscore:
                     173.2, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVRSVAEVTDTDDDIKTPNWRSKRVVLARNRVGFSVHETTLYAG
                     TVNDFWYANHVEAVFVTEGEGELLDKETGITYQLGPGSLYLLDGHEHHQLRPRTEMKTV
                     CVFNPPVTGREVHDENGVYPLIVEPQPDEEVQGAGRRTTA"
     gene            complement(5454..6701)
                     /gene="ectB"
                     /locus_tag="EV186_RS02920"
                     /old_locus_tag="EV186_101597"
     CDS             complement(5454..6701)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (22-357). E-value: 3.1e-71.
                     Score: 232.1. Matches aSDomain:
                     nrpspksdomains_EV186_RS02920_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787752.1"
                     /locus_tag="EV186_RS02920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101597"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_133847519.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.1e-74, bitscore:
                     248.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEDLESEVRSYCRSWPVVFDRAVGSRLYDEDGREYLDFFAGA
                     GALNYGHNNPVLKQAVIDYMMRDGITHALDMHTVAKREFFQTLQDVVLAPRDLDYKVML
                     PGPAGANAVEAALKLARKITGRESVINFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHA
                     TPMPYDNYLDGQVPDFLWFEKLLADSGSGLNEPAAVIVETVQGEGGINVARLEWLRGLA
                     ELCKRHGMLLIVDDVQMGCGRTGPFFSFEGAGFTPDIVCLSKSIGGYGLPLALTLLRPD
                     LDVWEPGEHNGTFRGINPSFVAARTALTTYWSDRELEEATLAKGEHVAARLEKLVVEFP
                     ASGLTAKGRGLARGLQFPDGDTANKVCRAAFDRGLLMETSGPQGEVAKIMPALTITEDE
                     LDGGLDILADAVRTVS"
     aSDomain        complement(5631..6635)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV186_RS02920_Aminotran_3.1"
                     /evalue="3.10E-71"
                     /label="EV186_RS02920_Aminotran_3.1"
                     /locus_tag="EV186_RS02920"
                     /protein_end="357"
                     /protein_start="22"
                     /score="232.1"
                     /tool="antismash"
                     /translation="DRAVGSRLYDEDGREYLDFFAGAGALNYGHNNPVLKQAVIDYMMR
                     DGITHALDMHTVAKREFFQTLQDVVLAPRDLDYKVMLPGPAGANAVEAALKLARKITGR
                     ESVINFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHATPMPYDNYLDGQVPDFLWFEKL
                     LADSGSGLNEPAAVIVETVQGEGGINVARLEWLRGLAELCKRHGMLLIVDDVQMGCGRT
                     GPFFSFEGAGFTPDIVCLSKSIGGYGLPLALTLLRPDLDVWEPGEHNGTFRGINPSFVA
                     ARTALTTYWSDRELEEATLAKGEHVAARLEKLVVEFPASGLTAKGRGLARGLQF"
     gene            complement(6742..7248)
                     /gene="ectA"
                     /locus_tag="EV186_RS02925"
                     /old_locus_tag="EV186_101598"
     CDS             complement(6742..7248)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787753.1"
                     /locus_tag="EV186_RS02925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101598"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_133847520.1"
                     /transl_table=11
                     /translation="MSGKRAERGDVVVVAPSIVDGAALWRIARDSGKLDLNSSYAYLLW
                     CRDFAATSRIARIDGEVAGFVTGYLRPDAPDTLVVWQVAVDQRFRGQGLAATLLDELVA
                     DVAAKGARYLETTVTPDNEASVALFTGLARRLRTEHERTDLFIREQFPDEHETEVLHRI
                     GPFSR"
     gene            complement(7390..8574)
                     /locus_tag="EV186_RS02930"
                     /old_locus_tag="EV186_101599"
     CDS             complement(7390..8574)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631931.1"
                     /locus_tag="EV186_RS02930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101599"
                     /product="DUF445 domain-containing protein"
                     /protein_id="WP_243753913.1"
                     /transl_table=11
                     /translation="MPVMAAVIGYITKLVAIKMMFEPLEFVGRKPFFGWQGIVPRRAAR
                     MASIACDTMTDKLISAAEVVGRLDPQRVAKEIEKPLLDAVEEITRDVAAEYQPGLWESM
                     PDAARRLLIRRIQAESPKMVAAIMETLQQDIDQVFDLKSMVVTNLVKDKALLNRIFREA
                     GRKEFQFIARSGIFFGFGIGLIQMFAWAALHSAWVMPLFGLMTGWFTDWLALKMIFNPK
                     EPVRYLGLFEWQGLFLKRRKEVAADYGDLIAREIITPHNVIEAVLKGPLADRVFAVVHR
                     QVQDVIDRQSGLVRPLVVLAVGSRKYQAMKHRIAEKVMDRLPETMSYIEDYAGEAMDIR
                     NTLVTKMQELTTEEFEALIRPAFEQDEWILITVGAVLGFAVGELQVLMVENFAR"
     gene            complement(8686..9522)
                     /locus_tag="EV186_RS02935"
                     /old_locus_tag="EV186_101600"
     CDS             complement(8686..9522)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337650.1"
                     /locus_tag="EV186_RS02935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV186_101600"
                     /product="Abi-alpha family protein"
                     /protein_id="WP_243753792.1"
                     /transl_table=11
                     /translation="MVERGELARVARARDAVAKSRGDGQSGGQGDGRAGQGDEDRGVVE
                     EAVAGAGRAAGWLFKAGLSVTKRLPGAELAGQQLRKLEDLAVNEVRKRLDGVDGPTGWP
                     TPEDDDEAVEVRAFERDPLRGAMATLLNRSVSETRKEAENHLFVGVMRQLTPDEARIVA
                     ALSDGTAYPLVHVAGKGQQVILQNASTVGKAAGVTLPDLTPLYVSRLLAAGVAEVGDED
                     PGLATQYDILLTETYVREAEKQAKRPKYLRHTLRLSAFGHRFWQACDPSIQQLPPG"
ORIGIN
        1 aactaccggt agagggaggg acaccgtgat cgaaagctgg atagcgatcg gggacagctt
       61 caccgagggc gtgggggacg aagggccgga cggcgtgtgc atcggctggg ccgatcgcct
      121 cgcgacacag ctcgccgccg tgaacccgtc gttctcctac gcgaacctcg cgctgcgcgg
      181 aaagatgatg aaggagatcc tcgacgacca ggtgccgatc gcggtcgcgg aacgaccgga
      241 tctgatcacg ctctgcgcgg gcggcaacga catcatcgtg ccgggcgtcg acatcgacga
      301 gatcgccgcg atgttcgacg ccgcggtggc cgccttgcgc gcgaccggcg cccaggtgct
      361 ggtgttcacc gcgccggacg tgaagttcca gccggtggtg cgcatggtgc gcacgaaggc
      421 ggccatctac aacgcgcaca tccacgcgag cgccgatcgc cacggcgcca aggtcgtgga
      481 cctctggtcg atgtcgacgc tgcgcgaccg gcgcgcctgg tcggatgacc ggctgcactt
      541 cgcccccgac gggcaccggc gcatcgccct gcgcacggcc gaggtgctcg gcctgccggt
      601 gaccgaggac tggcgtgagc ccctccccga gcaaccgccg ttgcgttggc tggacatgcg
      661 ccgcatggac gtgagctggg cccgggccca cctgatcccg tggatcggcc gccagctgcg
      721 tggccagtcg ctgggcgacg gcctggcccc gaagcgcccc cggctcaccc cgtaccggat
      781 accgaaggaa cctcagctgc agagcctgaa ggacgtcacc acctgctgaa acgggaccgg
      841 ccggcgctct cccctggtcg ccggccggtc cgcaggcgac acgtccccac cttgtcccat
      901 tcgtgccgcc cgagtggcgc gggacaccgc cagccccgcg ccgcccgaca gggtgtcagg
      961 ttctttccgg tcagcactaa atgtcggcta aacatctggt tgcagacggt cgaggtcggc
     1021 ttggacctcg gccgcggccc gctgggagac gtcggcgtag cggcgtgcgg cggccaccag
     1081 ctgactgcgt gcagccgcct tgtcaccctt ggccagcaag actttgccga gcacgtgccg
     1141 ggcgaatcct tcctggaggg tcagcgccga ggtgacggcc tggtcgacgg ccgcgcgggc
     1201 gtagcgctcg ctgtcgtcga gctcgccgcg ttccaggtgc agctcgccca ggttggccac
     1261 ggcgaacacc gagaacccga gctcgccgat ctcccggtac agctcgaccg cccgctcggt
     1321 cgcggccacg gcgtcgtcga ggcgggcgag gtcgcggtag acctgcgcga gattgttcag
     1381 cagcgccgcc tcgacgggct tgaactcggc gcgccgcgcc agttccaggg ccttctccag
     1441 ccgggcgacg gcgggttcgt gctggccctg gtggtacagc gcggtgccga cgtcacggaa
     1501 cgcgatcgcc atcagggccg ggtctcgcaa ccgggtggcg atggcgaccg agcgttcggc
     1561 gtccggcagc atctcgtcga gccggcccag ccggtagcgc gccgagcacc ggcacgacag
     1621 catccagacc tcgccgacgc cgtcgttcgc cgctcgcgcc gccgcgagtc ctttgtcgag
     1681 caacgccagc cagtcgtcgc ggatcgaccg cacagcacgg aaatcgtgca cgagccgggc
     1741 gaggtgccac acctggacgt ggtgctcggc cgcggccgca gcgtccaaag tggacatcag
     1801 gttggcccac tgcgaaccga accagtccag tgcggactcg gagtcggtga ccggcgccaa
     1861 ggactccttc gggtagtccg aggcgtagtc gaggccgtcc gcgggcgggc gcaggaaccg
     1921 ccgggcctgg tcggccgccg cgaggtagta ggtctccagc cggcgcaacg cctcggatcg
     1981 ctggtgctcg tacaggtccg cgcgcgcgag ggtggccgcg tgcatccgga ccaggtcgtg
     2041 caggtggtac tcgccgtcgg ttccgtccgg caccagcagg gaccagtcgg ccatcgtccg
     2101 cagccgctcg gccgcctcct cgaccggcac cccgcacaac gcggccgccg cgtaggcgtc
     2161 gagcatgggg ccggggaaca gccccaacag ccggaacgtg gcggcgagcc ggcccggcaa
     2221 cgcccgatag gtcgcatcga gcgcggcccg cacgctgacc tggttgtctt cggccgcaag
     2281 cacatccagc tggccctggc cggagagctc gtcggccagc cgcgccgccg tccactgtgg
     2341 atcggcggcg agccgggcgc ccgcgatccg caacgccaag ggcaacccac cgcacaactg
     2401 ggccagccgg atgcgatcgg cgcgttcgtc gtcactgccc gggcccgcgg tcgacgcgag
     2461 cacctcgagc gcgtcctcgc gcggcagcgt gccgagggtc agcatccgcg cgccgctgcc
     2521 gacgaccagc gcgtccagcc ggatcctgct ggtcaccagc accagcgccg acgcgctgcc
     2581 gggcaacagc gggcgcacct gctcggagtc gcgcgcgtcg tcgagcacga ccagcatccg
     2641 gcggtcggcc agcagcgacc ggtagagcgc cgcgcgttcg tccagctcga cgggcacctc
     2701 gccgaccggg acaccgagcg ccagcaggaa ccgcagcaac agctgggccg ggtcggcctt
     2761 ggcccggtgc acgtcgaacc cgcgcaacga cgcgtagagc tggccgtccg ggaaccgccg
     2821 cgccacccgg tgcgcccacc gcaccgcgag cgcggtcttg cccacccccg ccgggccgat
     2881 cagcccggcg atcggggtcg ccgccatgtc cacagtggag aggtgctcgt ccagccatgc
     2941 cagttcggcg gcccgcccgg cgaaacccgc cgtggtgttg ggcaactgcg cgggcaccag
     3001 caccccgacc atcggcgggc ggggcgtcgg ctgttcgatg tcgagcaggg acgtgtcgtc
     3061 gtgcagcacg cgttcgtgca gcatccgcag ctgcggaccg ggatccatgc cccgctcggt
     3121 cccggcccgg cgcgcgaacc gctggtaggt ctccaacgcc gccgcgcgcc ggcccgaccg
     3181 gtacaacgcc aggatcagct ggcgcaccag gtgttcgcgg aacgggtgct cgtcgaccag
     3241 cgccgcgagc tcgccgacga gttcgtcgtg cgcacccaat tccaggtcgg cgtccacccg
     3301 ggcctcgagc acggccaggc gcagctccgc gagctccggc gcgggcaccc ggtccttgat
     3361 gtcggcgagc gcgggaccac gccagatccg ctgcgcctcg cgcagcagtt cggcccgccg
     3421 ccgtgcgggc tcaccacgcg agcgagccag cagccgctgc gcccacgtca cgtcgatccg
     3481 gctctcgtcg accaccagca ggtacccggg cgggcgggtc tcgatcgcga ccgagcccga
     3541 cgggtcggtc tcggccagca gcttgcgcag ccgcgagatg tagccctgca cgatggtgcg
     3601 cgccgtcgcg ggcggttcgt gggcccacag gacgtccacc atccggtcca acgggacgac
     3661 ctggttggcg ttcagcagca gcaacgcgag gacggcacgc gtgcccggcc cacccagcgg
     3721 gaggggatcc tcaccgacca gcgcggcgat cggtccgagc aggcgaaatc gcacgccgcc
     3781 ggccgccgcc gctctaccac ccataccccg aacccccctg ccaccgccgt ccggcactcc
     3841 cccatgcgac ggcgtggaac caaactaggg gcgatcacac gcgatggctc gcaaacggga
     3901 tgtccatcaa ccgttcggag tagcgggaac agcacgcaac cccgcaccac ccggtcccga
     3961 tccggccggt gcggggtcac gcttcgtgcg gatggcgacc accagctgag cggacctcgc
     4021 cccgagtaaa aggagatccg gctcgctgac gctcgccaac gcgctcacct taccgtgtgc
     4081 gaacgagcga ctactgggcc atcaccggcg cagcggctcg aactcccggc tggcgatgaa
     4141 cgtcggccgc ggcgacggcg ccgcgtacgg ctcgacgagg gtgttctcca cgctgttgaa
     4201 aaccacgaag atgttcgagc gcgggaacgg cgtgatgttg ttgcccgagc cgtgcatgat
     4261 gttcgagtcg aacagcagtg cggagcccgc cggcccggtg aactggtcga tcccgtactt
     4321 ctcggcgagc gcggtgatgt cggcctggct cggcacgccg atctcctgct ccttcagcga
     4381 cgccttgtag tggtccgcgg gcgtttcccc cgcgcactgc acgaagctgc gctgcgaacc
     4441 cggcatgacc atcagcccgc cgttgaacgg gtagttctgg gtgagcgcga tcgacatgct
     4501 gaccgcgcga ggcagcggca tgccgtcctc ggcgtgccag gtctcgaagt ccgagtgcca
     4561 gtagaagccg gtgcccttga agcccggcat gtagttgacc cggctctggt gcacgtagac
     4621 ctcggagccg agcacctgcc gcgcccggtc gagcacccgc gggtcgcgca cgagctcggc
     4681 gatcagctcg ctgatcttgt gcacctcgaa gatcgaccgg acctcgcccg acgccttctc
     4741 cacgacggtg cgctcgtcgg ccttgagccg ctcgtcggtg gccagccggg tcagctcgtc
     4801 gcggtaggcc tggacctcgc caggcgagag cagcccctcg tagatcgaat aacccttggc
     4861 gtcgtgcgaa gccagggtcg ccgggtcgat cggcccgtcc ccgtgccccc acacggtggg
     4921 atcggtccgc tcgatcaggc cgggttcacc ggtgatccgg gtgatgtacc ggtcctcggt
     4981 cgtggtgtcg gcgatcgcgg tcatgccgtg gtcctccttc cggcgccctg gacttcctcg
     5041 tcgggctgtg gctcgacgat cagcgggtag acgccgttct cgtcgtgcac ctccctgccg
     5101 gtgaccggcg ggttgaacac gcacaccgtc ttcatctcgg tccgcgggcg gagctggtgg
     5161 tgctcgtgcc cgtcgagcag gtacaggctg cccgggccga gctggtaggt gatgccggtt
     5221 tccttgtcga gcagttcccc ttcaccttcg gtgacgaaca ccgcctcgac gtggttggcg
     5281 taccagaagt cgttgaccgt gcccgcgtac agcgtggtct cgtgcaccga gaaaccgact
     5341 cggttgcggg ccagcaccac ccgtttgctg cgccagttcg gggtcttgat gtcgtcgtcg
     5401 gtgtcggtga cctcggccac ggaacgcacg aacatgtggt tgctccctct cgctcagctg
     5461 accgtgcgga cggcgtcggc gaggatgtcc agcccgccgt cgagttcgtc ctcggtgatc
     5521 gtcagggcgg gcatgatctt ggcgacctcg ccctgcggac ccgaggtctc catcagcagc
     5581 ccgcggtcga acgcggcgcg gcagaccttg ttcgcggtgt cgccgtcggg gaactgcagg
     5641 ccacgagcca ggccgcggcc cttcgcggtc agcccgctcg ccgggaactc gacgaccagc
     5701 ttctccagcc gggccgccac gtgctcgccc ttggccagcg tggcctcctc cagctcgcgg
     5761 tccgaccagt acgtggtgag cgcggtgcgc gcggccacga acgacgggtt gatgccgcgg
     5821 aacgtgccgt tgtgctcacc cggctcccac acgtccaggt ccgggcgcaa cagcgtcaac
     5881 gcgagcggaa gtccatagcc accaatggat ttcgacaggc agacgatgtc cggggtgaac
     5941 ccggcgccct cgaagctgaa gaacggcccc gtgcgcccgc agcccatctg cacgtcgtcg
     6001 acgatcagca gcatgccgtg gcgcttgcag agttcggcca agccgcgcaa ccactccagt
     6061 cgcgcgacgt tgattccgcc ttcgccctgc acggtttcca cgatcacggc ggccggttcg
     6121 ttcaggccgc taccgctgtc agccaacagc ttttcgaacc acaggaagtc gggcacctgg
     6181 ccgtcgaggt agttgtcgta cggcatcggc gtggcgtgca cgagcgggat gcccgcgcca
     6241 ccgcgtttca tcgagttgcc ggtgaccgaa agcgcgccca gcgtcatgcc gtggaacgcg
     6301 ttggtgaagt tgatgaccga ctcgcggccg gtgatcttgc gggccagctt gagcgcggcc
     6361 tcgaccgcgt tcgcccccgc cggcccgggc agcatcacct tgtagtcgag gtcgcgcggg
     6421 gccagcacga cgtcctgcag cgtctggaag aactcgcgct tggccacggt gtgcatgtcc
     6481 agcgcgtgcg tgatgccgtc acgcatcatg tagtcgatca cggcctgctt gagcacgggg
     6541 ttgttgtgcc cgtagttgag cgcgcccgcc cccgcgaaga agtccaggta ctcccggccg
     6601 tcctcgtcgt agagcctgct gccgacggcg cggtcgaaca ccaccggcca actgcgacag
     6661 tagctgcgaa cctcggattc gaggtcttcg aagacgttca actcaactcc tttgtggtgc
     6721 cgtggcgcat taccgcggca cttaccgact aaacggcccg attcggtgca gcacctctgt
     6781 ttcatgctca tccggaaact gctctcggat gaacagatcg gtgcgttcgt gctcggttct
     6841 cagccgtcgc gcgagcccgg tgaacagcgc caccgaggcc tcgttgtccg gggtgaccgt
     6901 cgtctcgagg taccgcgcac ccttcgccgc gacgtccgcc accaactcgt ccagcagcgt
     6961 cgcggccagc ccctggccac gaaaccgctg gtcgacggcg acctgccaga cgacgagcgt
     7021 gtccggcgcg tccggccgga ggtacccggt cacgaagccg gccacctcac cgtcgatgcg
     7081 cgcgatccgc gaggtggccg cgaaatcacg gcaccacagc aaatacgcgt aggacgagtt
     7141 cagatcgagc ttgccggagt cgcgcgctat tcgccacagt gcggcgccgt ccacaatgga
     7201 cggcgcaacg acaaccacat caccgcgctc ggcgcgtttc cccgacatac cagagcaacg
     7261 taaccagaag gcttttccgt ggccagccga cgatggtcgg gaaccccgcg atcacctggg
     7321 gattcgcaga tggccgcgtg agaatggcaa caccgctgtt gcccctggtc cgcgccctgc
     7381 ggtagcgcct cagcgggcga agttctccac catgagtacc tggagttcgc cgaccgcaaa
     7441 ccccagaacc gcgccgaccg tgatcaggat ccactcgtcc tgctcgaacg ccgggcggat
     7501 caacgcctcg aactcctcgg tcgtgagctc ctgcatcttc gtgaccagcg tgttgcggat
     7561 gtccatggcc tcgccggcgt agtcctcgat gtagctcatg gtctccggca gccggtccat
     7621 caccttctcg gcgatgcggt gcttcatggc ctggtacttg cggctgccga cggcgagcac
     7681 caccagcggg cgcacgaggc cggactggcg gtcgatcacg tcctgcacct gccggtgcac
     7741 gacggcgaac acgcgatcgg ccaacggtcc tttgaggacc gcctcgatca cgttgtgcgg
     7801 ggtgatgatc tcccgcgcga tcaggtcgcc gtagtcggcc gcgacctcct tgcgccgctt
     7861 gaggaacagg ccctgccact cgaacagtcc gaggtagcgc accggctcct tcgggttgaa
     7921 gatcatcttc agcgcgagcc agtcggtgaa ccagccggtc atcaggccga agagcggcat
     7981 cacccacgcc gagtgcagcg cggcccaggc gaacatctgg atcaggccga tgccgaagcc
     8041 gaagaagatc cccgagcggg cgatgaactg gaactccttg cgccccgcct cgcggaagat
     8101 gcggttgagc agcgccttgt ccttgaccag gttggtcacg accattgact tgaggtcgaa
     8161 gacctggtcg atgtcctgct gcagggtttc catgatcgcc gcgaccatct tcggcgactc
     8221 ggcctggatg cggcggatca gcagccgccg tgccgcgtcc ggcatcgact cccacaggcc
     8281 gggctggtac tcggcggcga cgtcgcgggt gatctcctcg accgcgtcga gcagtggctt
     8341 ctcgatctcc ttggccacgc gttgcgggtc gaggcggccg accacctcgg cggcggagat
     8401 cagcttgtcg gtcatcgtgt cgcaggcgat gctcgccatc cgcgccgcac gccgcggcac
     8461 gatgccctgc cagccgaaga acggtttgcg cccgacgaac tccagcggct cgaacatcat
     8521 cttgatggcg accagcttgg tgatgtaccc gatgaccgcc gccatgaccg gcatcgagag
     8581 gtagacgtac cagtgcgcct ggaagtcctc gaggaacgcg cgcaaccgat cacccccggg
     8641 tgtttggccg gaagcatctc acgggccggg ccggatcagc gctggtcacc cgggtggtag
     8701 ttgctggatg ctcgggtcgc aggcctgcca gaaccggtgc ccgaacgcgg agagccggag
     8761 cgtgtgccgc aggtacttgg ggcgcttggc ctgcttctcg gcctcgcgca cgtaggtctc
     8821 ggtgagcagg atgtcgtact gggtcgcgag gcccgggtcc tcgtcaccga cctcggcgac
     8881 gccggcggcc agcaggcggg aaacgtagag cggcgtcagg tccggcaggg tcacacccgc
     8941 ggccttcccg acggtcgagg cgttctgcag gatgacctgc tggcctttgc ccgcgacgtg
     9001 caccagcggg tacgccgtgc cgtcggacaa ggcggccacg atacgggcct cgtcgggcgt
     9061 gagctggcgc atgaccccga cgaagaggtg gttctcggct tccttgcggg tctcgctgac
     9121 cgaccggttg agcagcgtgg ccatcgcccc gcgcaagggg tcgcgctcga acgcccggac
     9181 ctcgacggcc tcgtcgtcat cctcgggcgt cggccagccg gtcggcccgt cgacgccgtc
     9241 gagccgcttg cgcacctcgt tgacggcgag gtcttccaac ttccgcagct gctgcccggc
     9301 cagctccgcg cccggcaacc gcttggtgac gctcaacccg gccttgaaca accacccagc
     9361 cgctcgcccg gcacccgcga cggcctcctc gacaaccccg cggtcctcgt ccccctgacc
     9421 ggcccggcca tcaccttgcc cgccgctttg cccgtcaccg cggctcttcg ccacggcatc
     9481 ccgcgcccgc gccacccgcg ccaactcacc ccgctcaacc accgcgccat tacaccaccg
     9541 ccccacccca cccacccgcg tccagccacc ctcaaacccg aaaagagttc agcaggctta
     9601 atcccccgca accccctgac cagccgcttc acccctcctg ggcctcaccc cagtcacccc
     9661 cgccgagact ccccgaacat gagcggcatt cagcggacta aatcccaccc aacccactga
     9721 cctgcggatc tggagttcag cgggcttaat cccacgccca gccagacgcg aacaggcctc
     9781 agggacctcg ctcccccgac aggtgctgac cagacgatcc ggacgtccgc agactcgatc
     9841 cccaacgccc ttggtgagcc ccgaacgtga gaggtgttca gcgggctaaa tcccgcgcaa
     9901 gccgctgacc tgcggattca gagttcagcg ggcttaaccc aggcccggca aacatgagga
     9961 gggttcagcg ggcttgttca ctccagagtg cgctgacctg aggacttgga acacgcggga
    10021 gtcggtcggc ggcggcgcca gcgggtgccg aaggtgagag gtgttcagcg ggcttgatcc
    10081 tgccgatgtc cgctgacctg cgggttcgga gttcagcggg cttaatcccg ggccgggcaa
    10141 acgcgaagag ggttcagcgg gcttgttcac cggggagtgg gctgagctgg gggttgggtt
    10201 cagtgggctg atctggaggg tggggcgagg ggtggggtgg gttattggtg ctgtgggtgg
    10261 tgggaggagg ggttgtcgcc cgaaagggca gttatcccca gcttgatcca cagcggtgga
    10321 ctactcagcg caactttgtg cgttcgtgca caaggttgac ctcgagcagc agcgcccgct
    10381 cgccgagcac ctcgccgggc gtgcccccgg cgacgatccg gtgatcctcc ccgaa
//
