LOCUS       NZ_SLWR01000017        24597 bp    DNA     linear   CON 05-APR-2024
DEFINITION  Kribbella antiqua strain VKM Ac-2541 Ga0310564_117, whole genome
            shotgun sequence.
ACCESSION   NZ_SLWR01000017
VERSION     NZ_SLWR01000017.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kribbella antiqua
  ORGANISM  Kribbella antiqua
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 172619)
  AUTHORS   Whitman,W.B., Woyke,T., Klenk,H.P., Zhou,Y., Lilburn,T.G.,
            Beck,B.J., De Vos,P., Vandamme,P., Eisen,J.A., Garrity,G.,
            Hugenholtz,P. and Kyrpides,N.C.
  TITLE     Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase
            III: the genomes of soil and plant-associated and newly described
            type strains
  JOURNAL   Stand Genomic Sci 10, 26 (2015)
   PUBMED   26203337
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 172619)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 185.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004345665.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 04:15:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,825
            CDSs (total)                      :: 7,760
            Genes (coding)                    :: 7,713
            CDSs (with protein)               :: 7,713
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 7 of 47
            Pseudo Genes (incomplete)         :: 41 of 47
            Pseudo Genes (internal stop)      :: 3 of 47
            Pseudo Genes (multiple problems)  :: 4 of 47
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:43:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 26603
            Orig. end                         :: 51200
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SLWR01000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24597
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24597
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24597
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14597](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14597
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(398..413)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.27"
                     /tool="antismash"
     gene            complement(660..1457)
                     /locus_tag="EV646_RS35580"
                     /old_locus_tag="EV646_11730"
     CDS             complement(660..1457)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008359158.1"
                     /locus_tag="EV646_RS35580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11730"
                     /product="ABC transporter permease"
                     /protein_id="WP_132156645.1"
                     /transl_table=11
                     /translation="MRKWYIKLLLSAGPMIGALATAIGVWYAVTYLVLGEDRRFMLPPP
                     HEVIKTSLLDPAHLDPMLDALALSVRVAVVGLVIAVVLGIAQAVVMVQTTWLERALYPY
                     AVILQTVPILALVPLLGIWFGYGFSSRVVVCVIISLFPMISNTLFGLQSPTAAAHDLFT
                     LNKATRWQRLVKLQLPAAVPAIFGGLRISAGLSVIGAIVGDTFFRQGLVGIGGLLDIYT
                     ARLQTEDLFTAIGLASLFGVAFFSVFATLDRIIVGRWYGAIHR"
     gene            complement(1454..2188)
                     /locus_tag="EV646_RS35585"
                     /old_locus_tag="EV646_11731"
     CDS             complement(1454..2188)
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008359159.1"
                     /locus_tag="EV646_RS35585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11731"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_241996538.1"
                     /transl_table=11
                     /translation="MSKTLVMEGVSKTFATGTVALTGVELVVASGDFVSVVGPSGCGKS
                     TLLRLAAGLERATDGRIEVEAESTSYVFQEPTLLEWRSALSNVELVGELRGLPKAERRQ
                     RAREAFDLVGLTGFEKQFPRQLSGGMRMRVSIARSLVAEPQLALFDEPFGALDEITRLR
                     MQTELQRLFQLKSFAGLFITHSIPEAVYLSNRVLVMSGRPGRIVADFNVPWAYPRSPEL
                     RYEPEFTALTGAVSAALEGDHP"
     gene            complement(2185..3372)
                     /locus_tag="EV646_RS35590"
                     /old_locus_tag="EV646_11732"
     CDS             complement(2185..3372)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008359160.1"
                     /locus_tag="EV646_RS35590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11732"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_132156647.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.2e-18, bitscore:
                     59.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPGEVISSLPGVRALDGSLVDLTLGEGRIVSVEAATTPSGWRVI
                     PAASEPHAHLDKALTGERVDPEQNDLPAAIAQWRDLAARIDSEDIYDRALRAVRRYVSR
                     GITTIRSHVDLPGTGDPMRGVDALVRLREYLGDRVTLQLVALAGHQTSDDVIEEALARG
                     IDILGGCPHLAPAPTPELTRLLDIAQRSGVPIDLHADEQVPAPELDLEMLAKEVIARGL
                     TQQVTASHCVRLGSLPPDQLAPVLELVKEAGIGIVTLPITNLYLQGREASHLVPRGLTA
                     VRAILDAGIPLAAGGDNLRDPFNPVGRADPFETTALLIAAGHLRPSEALAAVTTGARTV
                     LGLPQVGIEAGRPADLIVVPDTDLGNVLAGWDDTRIVLHGGRVVAVSHVSSMEAL"
     gene            complement(3369..4244)
                     /locus_tag="EV646_RS35595"
                     /old_locus_tag="EV646_11733"
     CDS             complement(3369..4244)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012955.4"
                     /locus_tag="EV646_RS35595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11733"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_199237380.1"
                     /transl_table=11
                     /translation="MSGLDDWFEIRELGDGVQLIAEPGHANSFLVSGTTTALLFDTGMG
                     IASIADVVPELTDLPLLVVNSHDHLDHRGGNASLLDHPRLIDIAAHPAGRHAEVDPEFL
                     RMYERAMRSVYADYLRYLELDAQSFFVAANLPRMRELPDLTGWQVPPVQPTRALADGDR
                     IDLGGRTLRVLHTPGHAPDAICLYDESTGTLIAGDTILAAAFWLHGDDADLKTFAASTA
                     RLAELSPARVLVAHNLLYELPGQSTAAVAYAANAVLQGESTPRPDKDLLGRPVDRHEVG
                     GVVILTEPAA"
     gene            4325..4870
                     /locus_tag="EV646_RS35600"
                     /old_locus_tag="EV646_11734"
     CDS             4325..4870
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF019498.4"
                     /locus_tag="EV646_RS35600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11734"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_132156649.1"
                     /transl_table=11
                     /translation="MNQDEVDARLGTAIRALRHTRQRTLVEIAAVTGLSHPFLSQIERG
                     RARPSMRSLFLIAEALGTTQQALLAEVSSSAEETPLIGAGTRLLLHEGGVDITEFAEIG
                     TSYEEFFTHARPEFLYVVTGTLEVETRVSDDAASNFTTVKARESIHYPGGTLHRFRRAS
                     AEPCVVLIVHGDEHVSRT"
     gene            4925..6439
                     /locus_tag="EV646_RS35605"
                     /old_locus_tag="EV646_11735"
     CDS             4925..6439
                     /EC_number="3.5.1.4"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017934477.1"
                     /locus_tag="EV646_RS35605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11735"
                     /product="amidase"
                     /protein_id="WP_132156651.1"
                     /transl_table=11
                     /translation="MNSLLQAFMRYERALLANDVPVLDELFAEGSETLRADGGAVLVGH
                     EHIAAFRAGRPGVPPRTLERVHLRELTPDAVVLMAETSRPDGTTGIQTQLWQRLPKGWV
                     VTVAHVSTAPPARPVELPIDPVAWRIAPGDKPLVEGAEGPLSNLRVAVKDLFAVAGQRI
                     GAGNPAWLAEASVESAHAGAVAALLNAGADVVGIAQTDELAFSLAGTNIHYGTPLNPAA
                     PGRITGGSSSGSAAAVAAGHADLGLGTDTAGSIRVPASYCGLYGLRTTHDVVDRSGLVA
                     LAPSFDAVGLLARTGAVLAAGAEVLLPAAEVMPARELLVAPTLMELAAPDTRLAVEAAL
                     RALMLRLDLPVREVDVDRAALEEWFLAFRKVQSAEAWRIHGEFVAAHPGEFEPAVEARF
                     RSGAEVSDVEAARSILAEARSQLRELLPPGVVLALPSSASPAPPVDADAATIDTIRAGT
                     LRLTCLASLAGLPALSIPTARVGTLPAGLCLVGGPEADRSLLALID"
     misc_feature    complement(4968..4983)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            6497..7237
                     /locus_tag="EV646_RS35610"
                     /old_locus_tag="EV646_11736"
     CDS             6497..7237
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013053.4"
                     /locus_tag="EV646_RS35610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11736"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_132156653.1"
                     /transl_table=11
                     /translation="MTRNDWTLTSTTADLRRPPLPTSPVTFDAQPQQLTIDLARTAIVV
                     IDLQNDFCHPDGWLAGIGVDISGAQAPIAVLADFLPWLRSRDVPVVWVNWGNRPDQANL
                     PPGVRHVYDPAAEGNGIGSTTGPSGSPVLQAGSWAAAIVDNLKVDARDIQVDKYRMSGF
                     VDTPLDSILRNLRVDTLLFAGVNADQCVLNTLTDAANLGYDVVMLEDAVGTTSPSYCLD
                     ATVYNVRQCYGFTTTTTALRTQAN"
     gene            7269..8273
                     /locus_tag="EV646_RS35615"
                     /old_locus_tag="EV646_11737"
     CDS             7269..8273
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016668743.1"
                     /locus_tag="EV646_RS35615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11737"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_132156655.1"
                     /sec_met_domain="ADH_N (E-value: 6.8e-15, bitscore: 48.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.7e-17, bitscore:
                     56.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVIQGKLELTETELPTPDPGIGQVRLKVAYGGICGSDLHYYN
                     EGANGEYVVREPLVPGHELSGTVDLDPSGEWAAGTPVTIHPATFGNPEPGIEDRPHLWP
                     GGAYLGSASTWPHTQGGMSEFIVVRKDMVRLLPASLPLRRAALAEPLAVALHAIAIAGG
                     VKDQRVLVSGAGAIGLLAAAAAVSLGAAEVVSTDVLKGPLHRAQRLGVHGTVQVGVEQI
                     PSGRFDVVLECTGIATAITGALDAARRAGIVVLVGIPPNEPRPVNLSPLVSREIQLRGT
                     MRFNDEIDHAVALLDANPHFEQVITHEFPAGQAVEAFAVAKDSDSSGKVLIAL"
     misc_feature    complement(8282..8295)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: strong, score: 24.63"
                     /tool="antismash"
     misc_feature    8407..8422
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            8585..9997
                     /locus_tag="EV646_RS35620"
                     /old_locus_tag="EV646_11738"
     CDS             8585..9997
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391253.1"
                     /locus_tag="EV646_RS35620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11738"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_132156657.1"
                     /transl_table=11
                     /translation="MTLTEPDVNANGQQPQLSLGTAAARNLATTTKSEPQMQGITSRWL
                     LKLLPWVEAKGGAYRVNRRLSYAVGDGRVTFTTTGSEVRVIPQELCELSLLRSYDDVEV
                     LSALADRFVQQEFQPGDVIVERGRPADQICLIAHGKVNKIGLGKYGDESVLETLVDGDH
                     FTYKAILESDDFWEYTVKAITPVTLLTLSQASFEELVSQSDSLRAHVEDFRNSPELQSN
                     EYGEAAIELAAGHEGESDLPGTYVDYETSPREYELSVAQTVLRVHSRVADLYNHPMDQT
                     EQQLRLTIEALRERQEHEMVNNRDFGLLHNADLGMRIPTRSGPPTPGDMDELLSLVWKE
                     PAFFLAHPRSIAAFGRECTRAGIYPDTIDVGGHRLPAWRGVPIFPCNKLGISETRTSSI
                     LLMRTGEDSQGVIGLHQTGLPDEYEPGLSVRFMNISEKAIINYLVSAYYSAAVLVPDAL
                     GILENVEIGREG"
     gene            10001..12181
                     /locus_tag="EV646_RS35625"
                     /old_locus_tag="EV646_11739"
     CDS             10001..12181
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391254.1"
                     /locus_tag="EV646_RS35625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11739"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_132156659.1"
                     /sec_met_domain="T1TS (E-value: 1.5e-79, bitscore: 261.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPYELPDFYVPYPARINPNLEGARAHSKTWAYEFDMIDRPQQG
                     KAIWDEHDFDSHDYALLCAYTHPDATGPALDLVTDWYVWVFYFDDHFLELYKKTRDIPA
                     AKAYLDRLPAFMPTNGEITETPENPVERGLADLWTRTVPSMSPGWRQRFRQTTEALLAE
                     SLWELANISTGRLPNPIEYVEMRRKVGGAPWSANLVEYAANAEVPVEIAGTRPMQVLSD
                     TFSDAVHLRNDLFSYQREVEQEGELNNGVLVVERFLDCGVQQAAGLVNDILTSRLHQFE
                     NTAVTEVPRLFEEHQVDLPGRLAVLNYVKGLQDRQSGGHEWHLRSSRYMNNGGTAALGG
                     PTGLGTSAARIMTSLVASAPYRIRSHSFVLFQAVGASVLPPIYMPYAAKCSPHLAVARD
                     AVLEWGARMGISDGTIWDPRMLEQFDLALCAAGIHPDASADDLALSSQWLAWGTYADDY
                     YPAVFGPRRDLAAAKTTNARLSQFMPVEDAATPAPVTPLERSLADLWSRTAGRMHTADR
                     RLFRQTVDTMTDSWLWELANLAQNRIPDPVDYIEMRRRTFGSDLTMSLCRIGHGNRIPA
                     EVYRSRPIQALENAAADYACLLNDVFSYQKEIQYDGDFHNGVRVVENFLACDKNRALEV
                     VNELMTARMRQFEQLVADDLPALCTDFGLDDDVRRAVTGYAEELQNWMSGILVWHQGCH
                     RYEQSALPHRRPRPATGLGTSAFRIHRKVGAA"
     gene            12178..13554
                     /locus_tag="EV646_RS35630"
                     /old_locus_tag="EV646_11740"
     CDS             12178..13554
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391255.1"
                     /locus_tag="EV646_RS35630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11740"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_132156661.1"
                     /transl_table=11
                     /translation="MTAVDQLSLSTAAARQLATTTKSVPQMQGISPRWLLRMLPWVETT
                     GGTYRVNRRTTFTLGDGRLSFDVTGSDVRVIPAELTELPPLRDFGDPEVLAALADRFRR
                     EELEPGQVVAEFGSRVDDVVLIAHGKVAKTGVGEYGAGTDLGTIADGDYLGEQLMVEPP
                     ENLWEFTAKALTSCIVLKLSRSDFNELLERSEALRDHLDAVRRRPKPAQNKAGEAEIEV
                     ASGHAGEDALPGTYVDYDPAPREYELSVAQTILRVQTRVADLYNEPMDQTEQQLRLTIE
                     ALRERQEHELINNRDFGLLHNADYKQCIYTRTGPPTPDDFDELLTRRRKPRLLLAHPRA
                     IAAFGRECTKRRVYPETVEVEGRRVHAWRGVPLLPSNKIPISATNTTSVLVLRTGADDE
                     GVIGLRQTGLPDEVEPGLNARFMGINDKAVISYLVSTYYSVAVLVPDALGVLENVELGA
                     "
     gene            13566..14597
                     /locus_tag="EV646_RS35635"
                     /old_locus_tag="EV646_11741"
     CDS             13566..14597
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073756.1"
                     /locus_tag="EV646_RS35635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11741"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_132156663.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-57, bitscore:
                     188.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLQDDRSAADVLAWSRGQVEPALRAAVDSLPPATKRIVAYHFG
                     WEDEDGRPAHADGGKAIRPALVLLTAQAVGGTTEAALPAAVAVELVHNFSLLHDDVMDC
                     DTARRHRATAWTVFGLGPAILAGDALLGLAFDVLVASGHPCRGDAARMLGAAVQELVDG
                     QLADAHFETRDDVVPSECVRMAQLKTGALLGCCAALGALFGGGRPDQIDHLRLYGEDLG
                     LAYQYVDDLLGIWGKPAVTGKPVYSDLRRRKKSLPVVAALSSGTAAGRELAALYKQDGE
                     LTDAELMEAAALIEAAGGRETSQAQADALLAASLGELTASGALAPAATDLERLARLATR
                     RDY"
     gene            14615..15523
                     /gene="ispH"
                     /locus_tag="EV646_RS35640"
                     /old_locus_tag="EV646_11742"
     CDS             14615..15523
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0015968 - stringent response [Evidence
                     IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ispH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391257.1"
                     /locus_tag="EV646_RS35640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11742"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_338419310.1"
                     /transl_table=11
                     /translation="MRTVLLASPRSFCAGVERAIDIVERLLSSRPGPVYVRKQIVHNTH
                     VVEDLRARGAVFVDELDEVPDDATVVFSAHGVAPAVHAEAARRGLDVVDATCPLVTKVH
                     AEARRYAARGDTVVLIGHAGHEEVEGTLGEAPAVLVETVEDVAELEIEGPVSYLTQTTL
                     AVDETAAVVDALRNKFPELRGPSEADICYATTNRQTALAAVAAEANLVLVVGSANSSNS
                     KRLVELAVRNGTTAYLIDDVNDVQDVWLEGVEVVALTAGASAPPALVDEVIARLDPGEV
                     IEREVTRETVRFTLPAAVRQS"
     gene            15520..16287
                     /locus_tag="EV646_RS35645"
                     /old_locus_tag="EV646_11743"
     CDS             15520..16287
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391259.1"
                     /locus_tag="EV646_RS35645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11743"
                     /product="DUF4239 domain-containing protein"
                     /protein_id="WP_132156667.1"
                     /transl_table=11
                     /translation="MSLFATGLLWVGGMMLATGVLAVVLRKARQREGREANNEVAGQVF
                     TIVGGVNVVIAAFVLISLFDGMDKARDTTYDEANALVAVQWAGNSLPEPAKSRVQDLTK
                     SYATVVSEREWPAMRAGRVVGSEGWTLLAELRNTVEQTKTTTDRQEDSRVEAANQIWNV
                     YQARQVRLNSSGSDVSGVVWFAILIGSVMSVALMFMFGGPGIYSYAFMVSMLSGAIGLL
                     LFAIYQLQNPFSGGADVGPDAFVSALARLSDSG"
     gene            16421..17581
                     /locus_tag="EV646_RS35650"
     CDS             16421..17581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012921832.1"
                     /locus_tag="EV646_RS35650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_241996539.1"
                     /transl_table=11
                     /translation="MDVASGTTTDLGVLDYQVRAAGYSASQDLVYGIATHDKLGWLLRR
                     PQLVTVDRRGTLRTLGPVRYGIGGIAEPTAGAATSTRLYVRDVHRLYTLDIDPRSRSYQ
                     SVLKVVWLSPASLATDVDDFAADPSTGLLYGISTFGHVAKVVSLDPMSGAVRVIATVPG
                     APWQDSYSSVVVGPSELYAVHTGHGRRSQLFRIGFDGSSKELSSWKPLARSDAAGCLKQ
                     VVQSPPPPPPPTPTPTPTQKPSTPPPSPRPTATPTGTAAPPPPPPPPDEPGTPRPTQSR
                     TTAPSSRTPTPVLPQGDTSVPVRPPQSVPPTVPPTVPPTPPPSAAPSTPVVVRAAPRVA
                     AVPAEGDDRTVQVLRRWSLAMLLVILISGAAMAAQRRMRRMRQMRR"
     gene            17631..20108
                     /locus_tag="EV646_RS35655"
                     /old_locus_tag="EV646_11745"
     CDS             17631..20108
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="EV646_RS35655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11745"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_132156671.1"
                     /transl_table=11
                     /translation="MAVVRIAEELGSTGSARLVGRDHELRLLHDALRMPSGLVLVVGEA
                     GVGKTRLISEVAARHPARWLTAQCRPYEDSAPVVEEVLGSAAGSAVVLIEDIHWASPDA
                     LQMLRSFAGRITLVVTYRPEDARHQDDITSLAGSGARTTEVRVDPLDRGAVRELSAQLL
                     GLDLLPMALTDELARHTGGLPFAVEEFLRQVPDGADIEEQVRRALAETPAPVSLRASMA
                     VRLQEVPDSCRRVVCAAAVLATAAPENLLGAVSGITRSALTDAVDRALARGLLHEARPG
                     LYDLRHPLARRAVRATIPPDEVRRLHRQAATALAEVEPPPHARIAGHFRRGGVIDGWLT
                     HAELAADQSADAEQYAAMLQVEALPWADRARLAAKLGRTALAGPQWQDAVTTVQAVLAE
                     FPARSTARGRLRLALGLLLHDRAGDIPAGRRELTAAIDELAEDPASAAWAMSALAVPIF
                     GTEPIFEHRAWMQRALSLVGDAPDAAVRINQARFRLALGEVDVVEGFEVAGALAWLGHA
                     RRASALLERSDDSAVAAVTRLRLAFHSGDWAVIAEQLTRARAAAAGLPLVQAEVDLIDA
                     RLRLAQGDVAAGKELLASVVTRTELGPLPVHAAASAALAHDLDRCLALVRRKSGWVSAG
                     DLIVVTCTALLHEGRTEDARRLATEFTAIVSGLDAPAATAAALHAEAVVQQSVSLFSQA
                     AARYRAIGRQYDECVVLEQQGLLLLAQGNQEPLKSTARAYEAMGAHGDARRCQDALRAA
                     GVAVPRSRGRRGYGNTLSPRELEVARLAAEGLTNAQIAATLGLTVSTVEDHVSRALRKL
                     GLTSRHALGPHVR"
     misc_feature    18279..18281
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19782..19784
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20101..21273)
                     /locus_tag="EV646_RS35660"
                     /old_locus_tag="EV646_11746"
     CDS             complement(20101..21273)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024925.4"
                     /locus_tag="EV646_RS35660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11746"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_132156673.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.6e-13, bitscore:
                     44.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHLLLVGAWPELASRLVGLPGRVTLLQLDGMPGGSDLTPYARWA
                     ADLIHAPWDQPAKVVKLAAELHARDPLDVVAGYGEFTLSAVTAIAQHCGIRSVPGPADQ
                     RPGKAAQRAMLAAGGCMPVRCLVCDGPDDVRRFAAGRPVILKPDLGNGSLGVFAVTDAC
                     RIDEGWRWVRAAGLGAVLAEEMLAGPEFSVETRSVEGRHEVLMVTEKFTSGPPHFVEVG
                     HVMPARTAAGPSLEDEAVRALIALGHADGPAHVELILTEAGPAVVEVNRRLGGDRIWEL
                     LQLSTGIDVLRLVLLDALGKPPVVDRSVDAAAAIRFVHGDAAMFADGPPVQPTSVAAVP
                     GLVRFRWEPTTYHRRLGHVLTHAADPSRAVHAAEQACASFPDRPPAGTVT"
     gene            complement(21270..22415)
                     /locus_tag="EV646_RS35665"
                     /old_locus_tag="EV646_11747"
     CDS             complement(21270..22415)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013237.4"
                     /locus_tag="EV646_RS35665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11747"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_132156675.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5e-06, bitscore:
                     19.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSLGRGLRVGSLAVQGLAPEVEPAGPLTVSPEFATAYDQDLDDI
                     APVRYGRWGHRSAEQLEECLGRLDRGSSVVFNSGMAAVSSVLLALVRPGERLVLFEGGT
                     YYETRQIAEQLAGRGVAVRVIASMAELPEAVVGARLVVVESPSNPLLDLYDLRAVARIA
                     HDAGAIVAVDNSVASPLGQCPLELDADLVMSSDAKVIGGHNDLVLGHVSTRDDQLLKTL
                     QDWRYLHGSIPSAFTCWLALRSIGTLELRVERQNASAAALVKLLASRPEVTGLRWPGAP
                     ADPQHPIAAAQMRLGGGLLTFCLPDRAYLHRFLRSCRLIVPATSYGGLQSTANDIGAWP
                     HLNVPGGLVRISCGCEDTTDLVDDVRQALDLAALSLTAGLP"
     misc_feature    complement(22023..22025)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    22506..22521
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.17"
                     /tool="antismash"
     gene            complement(22557..24146)
                     /locus_tag="EV646_RS35670"
                     /old_locus_tag="EV646_11748"
     CDS             complement(22557..24146)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020576853.1"
                     /locus_tag="EV646_RS35670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11748"
                     /product="amidase"
                     /protein_id="WP_132156677.1"
                     /transl_table=11
                     /translation="MSAPMDEQVDRRSFLYRASALAAATTVGSIALPSIAHAAPATTST
                     ALVDVPARSVDVSELTIAEAATLIRKGRLTPEQLLEAYLDRIGKFDSIYQAFNLVLADE
                     ALARARTLGRSRGGALHGIPLAIKDNYYTRGVTTTANSYLFADFVPSYDATAVRRLTAA
                     GGIVLGKTQMGPLATTRATTPDGRITTVNAWTPADPSTDPGGSSSGSATAVAARMAASS
                     VGTQTGGSITAPSNAQNLTGLKPTMGRVSLHGIVPLSYTRDHPGPLARDAMDAAIMLTA
                     MAGEDPADPRTQGLPPVPDLVTAATPVIRSGKVRARWRTRIGVIPGFTSGTSETAVARK
                     TALDVLAGIDGLSVVDVTMPEEWDLLTNAAFNNVRLPERSEPFLPMLRSDLRGFGVSVT
                     GWLQGALLGANEYLIGQRAKVLLLQRVLDDLFEQCDVVVQTSPTPFDALGLPELALPIG
                     FTTAGIPIGTILGGKPYGEDRLLAVAAAYQSVTDWHHHRPADPVIPTATARTTAISDRG
                     RILAHEVPDLMQ"
     gene            complement(24143..24415)
                     /locus_tag="EV646_RS35675"
                     /old_locus_tag="EV646_11749"
     CDS             complement(24143..24415)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020576854.1"
                     /locus_tag="EV646_RS35675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_11749"
                     /product="hypothetical protein"
                     /protein_id="WP_199237382.1"
                     /transl_table=11
                     /translation="MSLAQPTDAELDVMIRARLASIGIDLDQLPAGSAPDPETGSPGRD
                     SVLASLRSFMRTTVLPLSAYSFGADALQVAPPKLYPSIDITREAR"
ORIGIN
        1 gccggtgtcg atctgcttct tggtgatcat gcccttcgac atcagcagcg ccgggatgat
       61 gtcgcccgcg gtcaccacca ccgcacccgt cttggcgacg tcggcgatcg tcttggcgtc
      121 cggatacgtc ttcgggtccc acatcaggat ctgcgggctc ttgttgagcg gggcaacgac
      181 cgcggtcgtc ggctgcttca ccgagcccga gatcgcggcg tccgagctga ccgcgccgat
      241 caggatgctc ttgtccagat acatcagcgc cggcaccggc tggaagccga ccgatggtcc
      301 gcctgcccgc acctccacct tgacgccggt atcgacgcca cccgcgacga gtggaccggt
      361 gacgcgcttc ttcgcggtgt cgatcgtgta gcccggcccg accagttggt acatcgccga
      421 gtgctcggcc tccggctgcc agtcctgctg catcacgacg gtcttcgggc acacactcga
      481 caggtccttg gccgagccag tggtggcggc cgaggtggct tgcactccgc cgcctgacgt
      541 cgtactcgcg gcgccgttgc cgcacgcgga caacgccagt acggcggtac cgaccacagc
      601 ggcggtgatc ttgcgattca tgggactcct cacaggggaa tgactaccga cgacagtgct
      661 tatctgtgga tggcgccgta ccagcggccg acgatgatcc ggtcgagcgt ggcgaagacg
      721 gagaagaacg cgacgccgaa cagcgacgcc agcccgatcg cggtgaacag gtcctcggtc
      781 tgcaaccgcg cggtgtagat gtccagcagg ccgccgatac cgaccaagcc ctgccggaag
      841 aaggtgtcgc cgacgatcgc gccgatcacc gacaacccgg cggagatccg cagtccgccg
      901 aagatcgccg gtacggcggc cggcagctgc agcttcacca gtcgctgcca gcgggtcgcc
      961 ttgttcagcg tgaacaggtc gtgcgcggcc gcggtcggcg actgcagccc gaacagggtg
     1021 ttggagatca tcgggaacag cgagatgatc acgcagacca cgacccggct gctgaacccg
     1081 tacccgaacc agatgcccag caacggcacc agcgcgagaa tcggcaccgt ctgcaggatg
     1141 acggcgtacg gataaagcgc ccgctccagc cacgttgtct gcaccatcac gacggcctgc
     1201 gcgatcccca gtacgacggc gatcaccagc ccgaccacgg cgacgcggac cgacagggcg
     1261 agcgcgtcga gcatcggatc gaggtgcgcg gggtcgagga gcgacgtctt gatcacctcg
     1321 tgcggcggcg gaagcatgaa ccgccggtcc tcgccgagca ccaggtacgt cacggcgtac
     1381 cacacgccga tcgcagtcgc cagcgcgccg atcatcggac cggcgctgag cagcagcttg
     1441 atgtaccact tcctcatggg tgatcgcctt ccagcgcggc ggaaacggca cccgtcagcg
     1501 ccgtgaactc cggttcgtac cgcaactccg gcgatcgcgg gtacgcccac ggaacgttga
     1561 agtcggcaac gatccggccc ggccgtccgc tcatcaccag cacccggttg ctcaggtaga
     1621 ccgcctccgg gatggagtgc gtgatgaaca ggcccgcgaa agacttgagc tggaagaggc
     1681 gctgcagctc ggtctgcatc cgcagccggg tgatctcgtc gagagcaccg aacggctcgt
     1741 cgaacagtgc gagttgtggt tcggcgacca gcgaccgcgc gatcgacacc cgcatccgca
     1801 tgccgccgga cagctgccgc gggaactgtt tctcgaagcc ggtcaggccg accaggtcga
     1861 acgcttcccg ggcgcgttgg cgacgctcgg ccttcggtag accgcgcagc tcgccgacga
     1921 gttcgacgtt cgacagcgcc gaccgccatt ccagcagcgt cggttcctgg aacacatagc
     1981 tggtcgactc cgcctcgacc tcgatccggc cgtccgtcgc tcgctccagt cccgcggcga
     2041 gccgcagcaa cgtcgacttg ccacagccgg acggcccgac gaccgagacg aagtcgccgg
     2101 aggcaacgac caactcgact ccggtcagcg caacggtgcc ggtggcaaac gtcttcgaaa
     2161 ccccttccat cacgagggtt ttactcacag cgcctccatc gagctcacgt ggctgacggc
     2221 aactactcga ccaccgtgca ggacgatccg ggtgtcgtcc cagcccgcga ggacattgcc
     2281 gagatcggtg tccggtacaa cgatcagatc tgcgggccga ccggcttcga tcccgacctg
     2341 cggcaggccc agcaccgtcc gggcgccggt cgtcactgcc gccaaagcct ccgaagggcg
     2401 caggtgcccg gcggcgatca gcaaggcggt ggtctcgaac ggatccgccc gtccgaccgg
     2461 attgaacgga tcgcgcagat tgtcaccgcc cgccgccaac gggatgcccg cgtcgagaat
     2521 cgcccgtacg gcggtcagcc cacgtggcac caggtgactc gcctcgcgcc cttgcaggta
     2581 gaggttggtg atcggcagcg tgacgatgcc gatgccggct tccttgacga gctcgagcac
     2641 gggcgcgagc tggtcaggtg gcagcgaacc gagtcgcacg caatggctcg cggtcacctg
     2701 ctgcgtgagc ccgcgcgcga tcacttcctt ggccagcatc tcgaggtcca gctcaggagc
     2761 aggcacttgc tcatcggcat gcagatcgat cgggacaccg gaacgctgcg cgatgtcgag
     2821 gagccgggtg agttcgggcg tgggtgccgg cgcgagatgc gggcaaccgc cgagaatgtc
     2881 gatgccccgg gcaagtgctt cctcgatcac gtcatcgctg gtctgatgac cggccagcgc
     2941 gacgagttgg agtgtcactc tgtcgccgag gtactcgcga agccggacca aggcgtcgac
     3001 accccgcatc ggatcgccgg tgccgggtag gtcgacatgg ctgcgaatgg tggtgatgcc
     3061 gcgtgacaca tagcgccgta ccgctcgcag cgcccggtcg tagatgtcct cgctgtcgat
     3121 ccgggcggcg aggtcgcgcc actgggcgat cgcggcgggg agatcgttct gctcgggatc
     3181 gacgcgttcg ccggtcagcg ctttgtcgag gtgggcgtgt ggctcggagg ctgcggggat
     3241 cacgcgccag ccgctcggcg tcgtggcggc ctcgacgctg acgatgcggc cttcgccgag
     3301 agtcaggtcg acgagcgaac cgtccagcgc acggacgccg gggaggctgc tgatcacctc
     3361 gccgggcttc atgcggcagg ctccgtgagg atgacgacgc cgccgacctc gtgccgatcg
     3421 accggacgcc cgagcagatc cttgtcgggt cgcggcgtgg attccccctg cagtacggcg
     3481 tttgcggcgt acgcgacggc tgcggtcgac tgcccgggca gctcgtagag caggttgtgc
     3541 gcgaccagga cccgtgccgg cgagagctcg gccagccgtg cggtcgacgc cgcgaaagtc
     3601 ttcagatcgg cgtcgtcgcc gtgcaaccag aacgcggctg cgaggatcgt gtccccggcg
     3661 atcagcgtgc cggtggattc gtcgtacaga cagatcgcgt cgggcgcgtg gccgggggtg
     3721 tgcagcacgc gcaaggttcg gccgccgagg tcgattcggt cgccatccgc gagcgcgcga
     3781 gtcggttgca cggggggcac ctgccagccg gtcaggtcgg ggagttcgcg catccgtggg
     3841 aggttggcgg cgacgaagaa gctctgcgcg tccaactcga gatagcggag gtaatcggcg
     3901 tacaccgatc gcatcgcgcg ctcgtacatc ctgaggaact ctgggtcgac ctccgcgtgc
     3961 cggccggccg gatgtgcggc gatgtcgatc agccggggat ggtcgagcag ggaggcgttg
     4021 ccgccgcggt ggtcgaggtg gtcgtgcgag ttcaccacga gcagcggcag gtcggtgagt
     4081 tctggtacga cgtcggcgat cgacgcgatc cccatgccgg tgtcgaacag cagcgcggtc
     4141 gtcgtacctg agaccaggaa gctgttggca tgacccggct cggcgatgag ctggactccg
     4201 tcgcccagct cccggatctc gaaccagtcg tccaagccgc tcaccttcag aatgttgatg
     4261 tgagtaacat taggaacggt acggacggtc agtttcagcc acgtttccgc ggaggatctg
     4321 ctgtatgaat caggacgagg tcgacgcccg gctggggacg gcgatccgcg ccctgcggca
     4381 cacccgccag cgcacgctgg tggagatcgc cgcggtgacc gggctgtcac atccgttcct
     4441 cagccagatc gagcgcggcc gcgcgcgacc ctcgatgcgg tcgctgttcc tcatcgccga
     4501 ggcactcggt acgacgcaac aggcgctgct cgccgaggtg tcgtcatcgg ccgaggagac
     4561 gccgttgatc ggcgccggca cgcgactcct gctgcacgag ggtggcgtcg acatcaccga
     4621 gttcgccgag atcggcacgt cgtacgagga gttcttcacc cacgcccggc cggagttcct
     4681 gtacgtcgtg accggcacgc tggaggtgga gacgcgtgtg agcgacgatg ccgcgagcaa
     4741 cttcacgaca gtaaaagcgc gcgagtcgat ccactacccc ggcggcacgc tgcaccgctt
     4801 ccgccgggcg agcgccgagc cctgcgtcgt cttgattgtc cacggtgacg agcatgtttc
     4861 ccgcacgtaa gcatctgcgt gcgaccaccc gccaccgctt gattgctacc tacgatcggc
     4921 tccgatgaac tcattgctgc aggcattcat gcgttatgag cgggccctgc tcgccaacga
     4981 cgtacctgtg ctggacgaac tgttcgccga aggctcggag acgctgcgag ccgacggtgg
     5041 tgcggtgctg gtcgggcacg agcacatcgc cgcgttccgg gctgggcggc ctggcgttcc
     5101 gccccgaacg ctggagcgcg tacatctacg cgagctcacg cccgacgcgg tcgtgctgat
     5161 ggccgagacc tcccgcccag acggcaccac cggcatccaa acccagctat ggcagcggtt
     5221 gcccaaaggc tgggtcgtaa ccgtcgccca cgtctcgacg gcgccgcccg ctcgtccggt
     5281 ggagcttccg atcgatccgg tcgcctggcg catcgcaccc ggcgacaagc cattggtgga
     5341 aggtgcagag ggtccgctga gcaacttgcg ggttgcggtc aaggacctct ttgcggtggc
     5401 aggccagcgg atcggcgccg gcaatccggc ttggctggct gaagcatctg tggagtcggc
     5461 acatgccggc gcggttgccg cgctgctgaa cgcaggcgcg gatgtcgtcg ggatcgcgca
     5521 gaccgatgag ctcgccttct ccttggccgg caccaacatc cactacggca cacctctcaa
     5581 tcccgccgca cctggccgga tcaccggcgg ctcgagtagc gggtcagcgg ctgcggtcgc
     5641 cgccggccac gccgacctcg gtctcggcac cgacacggcc ggctcgattc gcgtcccggc
     5701 gtcgtactgc ggcctttatg gactgcgtac gacgcatgat gtcgtggaca gatccggcct
     5761 ggtcgcgctg gcgccgtcgt tcgacgcggt tgggctgctc gcgcggacag gcgccgtact
     5821 cgcggctggt gctgaggtgt tgctgcctgc cgccgaggtc atgccggctc gggagttgct
     5881 cgtcgcgccc acgttgatgg agttggcagc acccgacaca cgactcgcag tcgaggcggc
     5941 gctgcgggcg ctgatgctgc ggttggacct tccggtgcgt gaggtcgacg tggaccgtgc
     6001 cgcgctggag gagtggttcc tggcgttccg caaggtgcag tcggccgagg cttggcggat
     6061 ccatggggag ttcgtcgcgg cgcatcccgg ggagttcgag cccgcggtgg aagcacgctt
     6121 ccggtccggt gccgaggttt ccgacgtcga ggctgcgcgc tcgatcctgg ccgaggcccg
     6181 ttcgcaattg cgtgagctgc tgccccctgg cgtcgtactc gcgctgccga gttcggcgag
     6241 tccggctccg cctgtcgatg ccgacgccgc caccatcgac acgatccgcg ccggcactct
     6301 gcgcctgacc tgcctcgcat ccctcgccgg actgcccgcg ctcagcatcc cgaccgcgcg
     6361 agtcggaacg ttgcccgccg gactctgcct ggtcggcggc cctgaggccg accgctcgct
     6421 gctcgccctg atcgactgat tgccgatcac ctgatcgccc ccaccgcgcc catcgcccca
     6481 tcgtcccgga gccgagatga cccgcaacga ctggaccttg acctccacca ccgccgacct
     6541 gcgccggcca ccgctaccga cgtcgccggt gactttcgac gcccagccgc agcagttgac
     6601 gatcgatctc gcgcgtacgg cgatcgtcgt gatcgacctg cagaacgact tctgccaccc
     6661 cgacggctgg ctcgccggca tcggcgtcga catctccggc gcccaggcac cgatcgccgt
     6721 actcgccgac ttcctgccgt ggctgagatc tcgcgacgtg ccggtggtgt gggtcaactg
     6781 gggcaaccgc ccggaccagg ccaacctgcc gccgggcgtg cggcacgtgt acgacccggc
     6841 ggcggaaggc aacggcatcg gctcgacgac cggaccgtcc ggatcaccgg tcctgcaagc
     6901 cggctcctgg gccgccgcga ttgtcgacaa cctgaaagtc gacgcccgcg acatccaggt
     6961 ggacaagtac cggatgagcg gcttcgtcga cacgccgctc gactcgatcc tccgcaacct
     7021 ccgcgtcgac acattgctct tcgccggtgt caacgccgac caatgcgtcc tcaacaccct
     7081 caccgacgca gccaacctcg gctacgacgt ggtgatgctc gaagacgcgg tcggtacgac
     7141 gtctccgtcg tactgcctgg acgcgaccgt ctacaacgtc cgccagtgct acggcttcac
     7201 cacaacgacc accgccctac ggactcaggc aaactagccc taccccgccg cctgaccgaa
     7261 ggagcccgat gaaggcgatc gtcatccagg gcaagctcga gctgaccgag accgaactgc
     7321 caacgccgga tcccgggatc ggtcaggtcc gcctgaaggt ggcgtacggc gggatctgcg
     7381 gctccgacct gcactactac aacgaaggcg cgaacggcga gtacgtcgta cgcgagccgc
     7441 tggtgcccgg acacgaactc tcgggcaccg tcgacctcga cccgtcgggc gagtgggcag
     7501 ccggtacgcc ggtcaccatc caccccgcca ccttcggcaa tcccgagcca ggtatcgagg
     7561 atcgcccgca cctctggcca ggcggcgcct acctcggcag tgcgtccacc tggccgcaca
     7621 cccagggcgg catgagcgag ttcatcgtcg tacgcaagga catggtccgg ctgctaccgg
     7681 cgtccctgcc gctgcgtcgc gccgccctcg ccgaaccgct cgccgtcgcg ctgcatgcca
     7741 tcgccatcgc cggcggtgtc aaggatcagc gggtgctcgt ctccggcgcc ggcgcaatcg
     7801 gtctgctcgc cgccgcggcc gctgtaagcc tcggtgccgc cgaggtggtg tcaacggacg
     7861 tgctgaaagg tccgctgcac agggcgcaac ggctcggcgt gcacggcact gttcaggtcg
     7921 gcgtcgagca gatcccgtcc gggcggttcg acgtcgtact cgagtgcacg ggcatcgcca
     7981 cggcgatcac cggtgcgctc gatgcggcgc ggcgggcggg catcgtcgta ctggtcggga
     8041 tcccgccgaa cgaaccgcgg ccggtgaacc tgtcgccgct cgtctcccgc gagatccagc
     8101 tgcgcgggac gatgcgcttc aacgacgaga tcgaccacgc ggtcgcactg ctggacgcca
     8161 acccgcactt cgagcaggtg atcacccacg agttcccggc cggccaagcg gtcgaggcct
     8221 tcgccgtggc caaggactcc gactcctccg ggaaggtgct catcgcactc tgaccccgaa
     8281 tgaaacaagc gtttgggagc tgatgtctcg tgggtacccg gcatttcgtc ggggtgccca
     8341 tcgcattgtt tcgggggttg gcgacgtccg aaacaagttg ccaacgcaaa cgtcttgacg
     8401 acctcggtca ccggccggtt actgtttgtg atgtacaggc cggggggaca gacacagggc
     8461 ctactggggg acccgcctac tagtcgaatt cggccatttt ccctgctcta cgggtggatg
     8521 ctcccacccg tagagcagtg cgccctacag cgccgattca aaaacgcctt ctgggggttc
     8581 agatatgacc ttgaccgaac cggatgtcaa cgccaacgga cagcagccac agctcagcct
     8641 cggcaccgcc gccgcccgca acctggcgac cacgaccaag tccgaaccgc agatgcaggg
     8701 catcacctcg cggtggttgc tgaagctgct gccgtgggtg gaagccaagg gcggcgcgta
     8761 ccgggtcaac cgccggctga gttacgccgt cggcgacggc cgggtgacct tcaccaccac
     8821 gggttccgag gtccgggtga tcccgcagga gctctgcgag ctgtccctgc tgcgcagcta
     8881 cgacgatgtc gaggtgctgt ccgcgctcgc ggatcgcttt gtccagcagg agttccagcc
     8941 cggcgacgtg atcgtcgagc gcggccgccc ggccgaccag atctgcctga tcgcgcacgg
     9001 caaggtgaac aagatcggtc tcggcaagta cggcgacgag tcggtgctcg agaccctggt
     9061 cgacggcgat cactttacct acaaggcgat cctggagtcc gacgacttct gggagtacac
     9121 cgtcaaggcg atcacaccgg tcacgctgct gacgttgtcg caggcatctt tcgaggaact
     9181 ggtctcccag tccgacagcc tgcgagcaca cgtcgaagac ttccgcaaca gccccgaact
     9241 ccagagcaac gagtacggcg aagccgccat cgaactggcc gccggacacg agggcgagtc
     9301 ggacctgccc ggtacgtacg tcgactacga gacgtcgccc cgcgagtacg agctgagcgt
     9361 cgcccagacc gtgctccgcg tgcacagccg ggtcgcggat ctctacaacc acccgatgga
     9421 ccagaccgag cagcagttgc ggctcaccat cgaggccctg cgcgagcggc aggaacacga
     9481 gatggtcaac aaccgcgact tcggcctgct gcacaacgcg gacctgggca tgcggatccc
     9541 gacccgcagc ggcccgccga cgccaggcga catggacgaa ctgctcagcc tggtctggaa
     9601 ggaacccgcc ttcttcctgg cccatccgcg gtcgatcgcg gcgttcggcc gggagtgcac
     9661 gagggccggc atctaccccg acaccatcga cgtcggcggc caccggctgc cggcttggcg
     9721 tggtgtcccg atcttcccgt gcaacaagct ggggatcagc gagacccgga ccagctcgat
     9781 cctgctgatg cggaccggcg aggacagcca gggcgtcatc ggcctgcacc agaccgggct
     9841 gccggacgag tacgagccgg ggctgtcggt gcggttcatg aacatcagcg agaaggcgat
     9901 catcaactac ctggtgagcg cgtactactc agccgccgta ctggtccccg acgcgctcgg
     9961 catcctcgaa aacgtggaga tcggccgcga gggctgacgc gtggcgcagc cctacgagct
    10021 gcccgacttc tatgtgccct accccgccag gatcaacccg aacctggagg gtgcccgggc
    10081 gcacagtaag acctgggcct acgagttcga catgatcgat agacctcagc aaggcaaggc
    10141 gatctgggac gagcacgact tcgactccca cgactacgcc ctgctctgcg cctacacgca
    10201 tccggacgcg accggcccgg cgctcgacct ggtgacggac tggtacgtgt gggtgttcta
    10261 cttcgacgac cacttcctcg agctttacaa gaagacgcgt gacatcccgg ccgccaaggc
    10321 gtacctggac cgcctgcccg ccttcatgcc gaccaacggc gagatcaccg aaaccccgga
    10381 gaacccggtg gagcgcggtc tcgccgacct ctggacccgc acggtcccgt cgatgtcgcc
    10441 cggctggcgg cagcggttcc ggcagaccac cgaggcgctg ctcgcggaat ccctgtggga
    10501 gctcgcgaac atcagcactg gccgcctgcc caacccgatc gagtacgtcg agatgcgtcg
    10561 taaggtcggc ggagccccgt ggtcggcgaa cctggtcgag tacgccgcga acgccgaagt
    10621 gccggtggag atcgccggca cgcgaccgat gcaggtgctc agcgacacgt tctccgacgc
    10681 ggtccacctg cgcaacgacc tgttctccta ccagcgcgag gtcgagcagg aaggcgaact
    10741 gaacaacggc gtcctggttg tggaacgctt cctggactgt ggtgtgcagc aggccgcggg
    10801 actggtgaac gacatcctca cctcgcggct gcaccagttc gagaacacag ccgtcaccga
    10861 ggtcccccgg ttgttcgaag aacatcaggt cgatctgccc ggccggctcg ctgtgctgaa
    10921 ttatgtgaaa ggcctgcagg accggcagtc cggcggtcat gagtggcatc tgcggtccag
    10981 ccggtacatg aacaacggtg gcacagcggc gctcggtggt ccgaccgggc tcggtacgtc
    11041 ggccgcgcgc atcatgacct cgctcgtggc gagtgcgccg taccggatcc gcagtcacag
    11101 ctttgttctg ttccaggctg tcggggcgag tgtgctgccg ccgatctaca tgccctacgc
    11161 cgcgaagtgc agtccacatc tggccgtcgc gcgtgacgcc gtactggagt ggggcgcacg
    11221 gatggggatc agtgacggga cgatctggga cccgcggatg ctggagcagt tcgaccttgc
    11281 gctctgcgcg gcggggatcc acccggatgc gtcggcggat gacctggcct tgtccagtca
    11341 atggcttgcc tggggcacct atgccgatga ctactatccg gcggtcttcg gtccgcggcg
    11401 cgatctggcc gcagcgaaga cgaccaacgc gcgactgtcc caattcatgc ccgtcgagga
    11461 cgcggccact ccggcaccgg tgactccgct ggaacgtagt cttgccgatc tgtggtcgcg
    11521 gaccgccgga cggatgcaca ccgcggaccg ccggctgttc cggcagacgg tggacaccat
    11581 gacggacagc tggctgtggg agctggccaa cctcgcccag aaccggatcc ccgacccggt
    11641 cgactacatc gagatgcggc ggcggacgtt cggctccgac ctcactatga gcctgtgccg
    11701 gatcggccat ggcaaccgga tcccagcaga ggtctaccgc tcccggccga tccaggcgct
    11761 ggagaacgcg gccgccgact acgcctgcct gctgaacgac gtcttctcgt accagaagga
    11821 gatccagtac gacggcgact tccacaacgg cgtccgggtc gtcgagaact tccttgcctg
    11881 tgacaagaac cgggcactcg aagtggtgaa cgagctgatg accgcgcgga tgcggcagtt
    11941 cgagcaactc gtcgcggacg accttcccgc gctgtgcacg gacttcggtc tggacgacga
    12001 cgttcggcgg gccgtcacag gctatgccga ggaactgcag aactggatgt ccgggatcct
    12061 cgtctggcac caaggctgcc accgctacga acagtccgcc ctgccccacc gtcgacccag
    12121 accagccact ggccttggca cgtcggcatt ccggatccac agaaaggtcg gtgcggcatg
    12181 acagcggtcg atcagctgag cctgagcaca gccgccgcga ggcagctggc caccaccacc
    12241 aagtccgtcc cgcagatgca gggcatctcg ccccgctggc tgctccggat gctgccctgg
    12301 gtggagacca ccggcggcac ctaccgggtg aaccggcgga ccacgttcac acttggcgac
    12361 ggccgtctca gcttcgacgt caccggttcc gacgtccggg tcatcccggc cgagctcacc
    12421 gagctcccac cgttgcggga cttcggcgac cccgaggtcc tcgccgccct ggccgatcgg
    12481 ttccggcgtg aggagctgga gcccggccag gtcgtggcag agttcggcag ccgggtggac
    12541 gacgtcgtac tgattgccca tggcaaggtt gccaagaccg gcgtgggtga gtacggcgcg
    12601 gggacggatc tcggcacgat tgccgacggc gactatctcg gcgagcagct gatggtcgag
    12661 ccgccggaga acctctggga gttcaccgcc aaggcactga ccagctgcat cgtgctcaag
    12721 ctgagccggt cggacttcaa cgagctgctg gagcgatccg aggcgttgcg cgaccatctg
    12781 gacgccgtac gacgacggcc gaaaccggcg cagaacaagg ccggcgaggc ggagatcgag
    12841 gtcgcgtccg ggcatgcggg tgaggacgca ctacctggga cgtacgtcga ctacgacccg
    12901 gcgccgcggg agtacgagct gagcgtcgcg cagaccatcc tgcgggtgca gacccgggtg
    12961 gccgacctct acaacgagcc gatggaccag accgagcagc agctgcggct caccatcgag
    13021 gccctgcgcg agcggcagga gcacgagctg atcaacaacc gcgacttcgg tctgctgcac
    13081 aacgctgact acaagcagtg catctacacc cgcaccggtc cgccgacgcc cgacgacttc
    13141 gacgagctgc tgacccggcg gcgcaaacca cgactgctgc tcgcgcatcc gcgggcgatc
    13201 gcggcgttcg gccgggagtg caccaagcgg cgcgtctatc cggagaccgt cgaggtcgag
    13261 ggccggcgcg tgcacgcgtg gcgcggcgta ccgctgctgc cgagcaacaa gattcccatc
    13321 tccgctacca acaccacatc ggtcctcgtc ctgcgtacgg gcgccgacga cgaaggcgtc
    13381 atcggcctac ggcagaccgg cctgccggac gaggtggagc ccggcctgaa cgcccgcttc
    13441 atgggcatca acgataaggc ggtcatctcc tacctggtca gcacctacta ctcggtggca
    13501 gtgctcgtcc cggacgccct cggcgtcctg gagaacgtcg aactcggcgc atgaggagcg
    13561 acgcgatgtc tactcttcaa gatgaccggt ccgcggccga tgtccttgcc tggagccggg
    13621 ggcaggtcga gcccgccttg cgagccgctg tcgacagttt gccgccagca acaaagcgca
    13681 ttgtcgccta tcacttcggc tgggaagacg aggacggccg tccggctcat gccgacggcg
    13741 gtaaagccat ccgtccagcg ctggtgctac tgaccgcaca ggcagtcgga ggtacgacgg
    13801 aagccgcgct gccggccgcg gtcgcggtcg agttggtcca caacttctcc ttgctgcatg
    13861 acgatgtgat ggactgcgac accgcccgca ggcatcgcgc cacggcctgg acggtgttcg
    13921 ggctcggtcc ggcgatcctg gccggggatg ccctgctcgg cctggccttc gatgtcctcg
    13981 tggccagcgg tcacccgtgt cgcggtgatg ccgctcgcat gctcggggcc gccgtacagg
    14041 agctggtcga cgggcagctg gccgatgcgc acttcgagac gcgggacgac gtcgtaccgt
    14101 ccgaatgcgt gcgtatggcg cagctcaaga ccggcgcgct actcgggtgc tgcgccgccc
    14161 tcggcgcgct cttcggcggc ggcagaccgg accagatcga ccacctcagg ctgtacggcg
    14221 aggacctcgg gctggcctat cagtacgtcg acgacctgct ggggatctgg ggcaagccag
    14281 ccgtcaccgg caagcccgtg tactccgacc tgcggaggcg gaagaagtcc ctcccggtgg
    14341 ttgccgcatt gtcctccggt acggcggccg gccgcgaact ggcggccctc tacaagcaag
    14401 acggcgagct gacggacgcc gaactcatgg aagcagccgc actgatcgaa gcggctggtg
    14461 gacgcgagac gagccaagca caggctgatg ccctgctggc tgcctcgttg ggggaactga
    14521 cggcatccgg ggcgctcgcg cccgcggcca cggatctgga aaggctcgcc aggctggcca
    14581 cacgccgcga ctactgaagt gaagggggat gcacatgagg acagttctgc tggcctcgcc
    14641 acgatcgttc tgcgccggtg tcgagcgcgc gatcgatatt gtcgaaagac tactgagctc
    14701 gcggcccgga cctgtctacg tccgcaagca gatcgtgcac aacacgcatg tggtcgagga
    14761 cttgagggct cggggcgcgg tcttcgtcga cgaactggac gaagttcccg acgacgcgac
    14821 cgtcgtcttc tccgcgcatg gtgtcgcgcc ggccgtccac gccgaggccg ctcgccgcgg
    14881 actggacgtc gttgacgcga cctgtccgct ggtgaccaag gtccatgcgg aggctcggcg
    14941 ctatgccgcg cgcggcgaca ccgtcgtact gatcgggcat gccgggcacg aagaggttga
    15001 aggaacgctc ggggaagctc cggccgtgct ggtcgagacg gtggaagacg tggcggagct
    15061 cgagatcgag ggtcccgtct cttacctgac ccagaccacg ctggctgtgg acgagaccgc
    15121 tgccgtggtg gatgccctgc gcaacaagtt tcccgagctg cgcggaccca gcgaggccga
    15181 catctgctac gcgaccacca atcgccagac cgcgcttgct gccgtcgctg cggaggcgaa
    15241 tctggtgctc gtggtcggat cggcgaactc gtcgaactcg aagcggctgg tcgaacttgc
    15301 cgtgcgcaac ggtacgacgg cgtacctgat cgacgacgtg aacgacgtac aagacgtttg
    15361 gctggaggga gtcgaggttg ttgccctgac cgcgggtgcg tccgctcccc cggcgctggt
    15421 cgacgaggtg atcgcgcgac tcgacccagg tgaggtgatc gagcgtgagg tgacgcggga
    15481 gaccgttcgc ttcacgctcc cggcagcggt gaggcaatca tgagtctgtt tgcgaccggc
    15541 ctgctgtggg tcggcggaat gatgctggcg accggtgtgc tggccgtcgt actgcggaag
    15601 gcgcggcagc gggaggggcg ggaggccaac aacgaggtcg ccggccaggt gttcaccatc
    15661 gtcggcgggg tcaacgtggt gatcgccgcg ttcgtgctga tctcgttgtt cgacgggatg
    15721 gacaaggcca gggacacgac gtacgacgaa gcgaacgcgc tcgtcgccgt gcagtgggcg
    15781 ggcaactcgc tacccgaacc ggccaagtcc agggtccagg acctgaccaa gtcgtatgcg
    15841 accgtggtgt cggagcggga gtggccggcg atgcgggcgg gacgggtcgt cggcagcgaa
    15901 ggctggacgt tgctggccga gctgcggaac acggtcgagc agacgaagac gacgaccgac
    15961 cggcaagagg acagccgggt cgaggccgcg aaccagatct ggaacgtcta ccaggcccgt
    16021 caggtccggc tgaactcgag cggcagcgat gtcagcgggg tggtctggtt cgcgatcctg
    16081 atcggcagcg tgatgtcggt tgcgctgatg ttcatgttcg gcgggccggg catctactcg
    16141 tatgcgttca tggtgtcgat gctgtcgggt gcgatcgggt tgctgctgtt cgcgatctac
    16201 cagctgcaga acccgttcag cggcggggcc gatgtcgggc ccgacgcctt cgtgtccgcg
    16261 ctcgcccgac tgagtgacag tggctaaggg tctccgagct ctggccgcgt tctgcctggc
    16321 cacgggcttc ttgaccactg gtccggctac tgcagcgacg gcctgttctt tcttggactt
    16381 tcagtcggct ggcttcacct cgcggtcccg gctggtccga gtggatgttg catcaggtac
    16441 gacgaccgac ctcggcgtac tcgactacca ggtccgcgcg gcgggttact cggcgagcca
    16501 ggacctcgtc tacggcatcg cgacgcacga caagctcggc tggctgctgc gccggccgca
    16561 gctggtcacc gtcgaccgcc gcgggacgct tcggaccctc ggtccggtgc gatacgggat
    16621 cggtggcatc gccgagccca cggccggggc ggccaccagc acccggttgt acgtgcggga
    16681 cgtgcaccgg ctctacacgc tggacatcga tccgcggagt aggtcgtacc agagtgtgct
    16741 gaaggtggtc tggctgtcac ccgcgtccct ggcgacagac gtggacgact tcgcggccga
    16801 tccctcgacg ggactgctct acgggatctc cacgttcggg catgtggcga aggtggtgag
    16861 ccttgacccg atgtccggtg ccgttcgggt gatcgccact gtgccgggcg cgccttggca
    16921 ggactcgtac agctccgttg tggtggggcc ttcggagttg tacgccgtcc acaccgggca
    16981 cgggaggcga agtcaactgt tccggatcgg gttcgacggg tcgtccaagg aattgtcgtc
    17041 gtggaagccg ttggcccgga gcgacgcggc gggctgtctc aagcaggtcg tccagtcacc
    17101 gcctccgcct cctccaccga cacctacgcc tactcccact cagaaaccgt cgacgccgcc
    17161 accatcaccg cggccaacag cgacaccgac tgggacggct gcaccaccac caccgccgcc
    17221 gccaccggac gagccgggca ctccccggcc gacgcagtcc cggacgacgg cgccgtcctc
    17281 ccggactccg actccggtct tgccacaagg cgacacgtcg gtgccggtgc gaccgccgca
    17341 gtcagttccg ccgacagtgc cgccgacagt gccgccgacc ccgccgccgt ccgcagcgcc
    17401 gagtacgccg gttgttgtcc gcgccgcgcc gcgggttgcc gccgtacctg ctgaaggaga
    17461 tgacaggacc gtgcaggtgc tgcggcggtg gtcgctggcg atgttgctgg tgattctcat
    17521 cagtggcgcc gcgatggcag cgcagcgacg gatgcgacgg atgcgacaga tgcgacgctg
    17581 acgcataaag cgacgccgtc gggggaacgg tcacgagggg gagcaagcag atggcggtgg
    17641 tgaggatcgc ggaggagctc ggatcgactg gttcggcccg gctggtcggg cgggaccacg
    17701 agcttcggct gctgcacgat gcgctcagga tgccgtctgg cctggtcctg gtggtcggcg
    17761 aggccggggt cggcaagacc agactcatct cggaggttgc ggcccggcac cccgctcgct
    17821 ggctcactgc gcagtgccgg ccgtacgaag actcggctcc ggttgtcgag gaggtcctcg
    17881 ggtcggcggc cgggtcggcc gtcgtactga tcgaggacat ccactgggct tcaccggacg
    17941 cccttcaaat gttgaggtct ttcgccggcc ggatcacgct ggtggtcaca taccggccgg
    18001 aggacgctcg gcatcaagac gacatcacgt cgctggctgg gagtggcgcg cggacgacag
    18061 aggtacgagt cgatccgctc gaccgaggcg ccgtacggga gctctcggcc cagttgctcg
    18121 gactggatct gttgccgatg gcactcaccg acgaactcgc gcggcacacc ggcggcctgc
    18181 ctttcgcagt ggaggagttc ctgcgtcagg tgccggacgg tgcggacatc gaggagcagg
    18241 tacgtcgtgc cttggcggaa acgcccgcgc cggtctcctt acgcgcatcc atggccgtgc
    18301 gtctccagga ggtgccggat tcctgccggc gcgtggtctg tgccgcggcc gtcctggcca
    18361 cagccgcgcc ggagaacttg ctgggcgcgg tgtccggcat aacccgctcc gcgctgaccg
    18421 atgccgtcga ccgtgccctg gcacgcggcc tcctccacga ggcccgacca ggcctgtacg
    18481 acctcagaca tcccctcgcc cgaagagcgg tcagggcaac gattccgcca gatgaggtac
    18541 gacgtttgca tcggcaggcg gcgaccgcat tggcggaagt cgagccgcca ccacatgcgc
    18601 ggatcgctgg gcactttcgc cggggtgggg tgatcgacgg ttggctgacg cacgccgaac
    18661 tcgctgcgga ccagtcggcg gacgcggagc agtacgccgc gatgctgcag gtcgaggcgc
    18721 tcccctgggc ggatcgcgcc cggctggctg ccaagctcgg ccggaccgcg ctggcaggtc
    18781 cgcagtggca agacgccgtc accaccgttc aggcggtcct tgccgagttc ccggcgcgca
    18841 gtacggcgag aggtcgactc cggctggcgc tcggactgct gttgcacgat cgagccggcg
    18901 atatcccggc cggtcggcgt gagttgactg ctgcgatcga cgaactggcc gaggacccgg
    18961 catcggcagc ctgggcgatg tccgcgcttg ctgtcccgat cttcggcacc gagccgatct
    19021 tcgagcaccg cgcgtggatg cagcgagcgc tctcactggt cggcgacgcg ccggatgccg
    19081 ctgtaaggat caaccaggca cgcttccggc tggcactcgg cgaggtcgat gtggtggagg
    19141 gattcgaggt tgcgggtgct cttgcgtggc tgggtcacgc gcgtagggcc tcggctctcc
    19201 tcgaacgttc tgacgacagc gcggtcgcgg ccgtcacgcg gctccggctg gcgtttcact
    19261 ccggcgattg ggccgtcatc gcggagcaac tgacgcgcgc acgggccgca gcggcaggcc
    19321 tgccgctcgt ccaagccgag gtcgacctca tcgacgcccg gctgcggctg gcccagggtg
    19381 atgttgccgc aggcaaagaa ctgcttgcct cggtcgtgac ccgcaccgaa ctcggcccac
    19441 taccggtcca tgccgccgca tccgcagccc tcgcccacga cctcgaccgc tgcctggccc
    19501 tggtacgacg caagtccggc tgggtgtcgg ccggcgacct gatcgtggtc acctgtacgg
    19561 cgttgctcca cgaaggccgc accgaggacg cgagacgact cgcgaccgag ttcaccgcca
    19621 tcgtctcagg cctggatgca cctgctgcca ccgcggctgc cctgcacgcc gaggccgtcg
    19681 tacagcaatc ggtgagcctg ttctcgcagg cggccgctcg gtatcgggcg atcggccggc
    19741 agtacgacga gtgcgtcgta ctcgagcagc aaggtctgct gttacttgct cagggcaacc
    19801 aggagccatt gaagtcgaca gcccgtgcgt acgaagcgat gggcgcgcat ggggatgcgc
    19861 gtcgttgcca ggacgccctt cgtgcagccg gcgtcgccgt tcctcgcagt cgcggccgcc
    19921 gcggctacgg caataccctc tcgccgcgcg aactggaggt ggcgcggcta gccgccgagg
    19981 gactcaccaa cgcccagatc gcggcgacgc ttgggctgac cgtcagcacc gtcgaggatc
    20041 acgtgtcccg agctctccgc aaactcggcc tcacctcacg ccacgccctc ggcccgcacg
    20101 tcaggtgacc gtgcccgccg gcggacgatc ggggaaggaa gcgcacgcct gctcggccgc
    20161 gtgaacggca cgagaaggat ccgcggcgtg agtgaggaca tggccaagcc gccggtgata
    20221 ggtcgtcggc tcccaccgga agcgaacgag gcccggcaca gccgcgaccg acgtcggctg
    20281 gaccggcggc ccatcggcaa acatcgccgc atccccgtgc acaaagcgaa tcgcggccgc
    20341 tgcgtcgacc gaacgatcga caacaggagg tttgccaagc gcatcgagga gcacaagacg
    20401 cagtacgtcg atgccggtgc tgagctgaag caattcccag atgcgatcac cacccagccg
    20461 tcgattgacc tcgacgacag caggcccggc ctcggtcagt atgagttcca catgtgccgg
    20521 tccgtcggcg tgcccgagtg cgatcaacgc gcgtaccgcc tcatcctcca gcgacggccc
    20581 ggcagcggtg cgagcgggca tgacatgacc gacttcgacg aagtgcggcg ggccggaggt
    20641 gaacttctcg gtcaccatca gcacctcatg ccggccctcg accgagcggg tctcaacgct
    20701 gaactccggc cccgccagca tctcctccgc cagcaccgca cccagccccg cggcccgaac
    20761 ccaccgccat ccctcgtcga tccggcaggc atcggttacc gcgaagacgc cgagactgcc
    20821 gttcccaagg tcgggtttga ggatgaccgg ccgtccggcc gcgaagcgcc gtacgtcatc
    20881 cgggccatcg cacaccagac atcgcaccgg catgcagcca ccggccgcca gcattgcgcg
    20941 ctgcgcggcc ttgcccggcc gctgatccgc cggaccaggg accgaccgga tcccgcagtg
    21001 ctgcgcgatc gccgtgaccg cgctcagcgt gaactcgccg tacccggcca ccacgtccaa
    21061 cggatcgcgc gcgtgcagct ccgccgcgag cttgaccacc ttggcgggct gatcccacgg
    21121 cgcgtggatg aggtccgccg cccagcgcgc gtacggcgtg aggtcactgc cgccgggcat
    21181 cccgtcgagc tggagcaggg tgacccggcc gggcaggccg acgaggcggc tcgccagctc
    21241 tggccaggca ccgaccagaa gcaggtggtt catggcagcc cggccgtcag gctcagcgcg
    21301 gcgaggtcga gcgcctgccg aacgtcgtca acgagatcgg tggtgtcttc gcaaccgcag
    21361 gagatccgca caagtccgcc ggggacgttc agatgcggcc aagcgccgat gtcgttcgcc
    21421 gtcgactgca acccgccgta gctggtggcc ggaacgatca gccggcagga acgcaggaac
    21481 cggtgcaggt acgcgcgatc cggcaagcag aatgtcaaca atccgccgcc gagccgcatc
    21541 tgcgccgccg cgatcggatg ctgcggatca gccggcgccc cgggccagcg caacccggtg
    21601 acttccggcc gcgacgcgag cagcttcacc agagccgccg cgctcgcgtt ctgccgttcg
    21661 acccgaagct ccagcgtccc gatcgaccgc agcgccagcc agcaggtaaa cgccgacggg
    21721 atgctgccat gcaggtatcg ccagtcctgc aatgtcttca gtagttggtc atcgcgagta
    21781 ctcacgtgtc cgaggacaag atcgttgtga ccaccgatca ccttggcatc gctcgacatc
    21841 accaggtccg cgtcgagctc cagcgggcat tgaccgagcg gcgaggcgac agagttgtcg
    21901 acggcaacga tcgcacccgc gtcgtgggcg atgcgcgcga cggcccgcaa gtcgtagagg
    21961 tcgagcaacg gattgctcgg cgactccacc acgaccagac gagctccgac gaccgcctcc
    22021 ggtaattcgg ccatgctcgc gatcacccgt acggcgacac cgcgaccggc caactgctca
    22081 gcgatctgcc gtgtctcgta gtacgtcccg ccctcgaaca gaaccagccg ctcccccggc
    22141 cgcaccaagg ccagcaacac cgacgacacc gctgccatcc cgctgttgaa gaccaccgag
    22201 ctgcctcgat ccagccgccc gagacactcc tccaactgct cggccgaccg atggccccag
    22261 cgtccgtacc gaaccggggc gatgtcgtcg agatcctggt cgtacgccgt cgcaaactcc
    22321 ggcgacaccg tcaatggccc ggccggttcc acctccggcg ccagcccctg caccgcaaga
    22381 ctccccaccc gcagcccccg ccccaacgag tccatccgcg cctcccctcc gcgaccagcc
    22441 gattactgtt cgcgaggggc aggttaaccg gttaatagcc cgacgagaag acctcggcga
    22501 ccctgaaggt gaatgattct ccggctttcg acggcgcggg gacgttccta aaggcgtcac
    22561 tgcatcagat cggggacctc gtgggcgagg atgcggccgc ggtcggagat cgcggttgtt
    22621 cgtgcagtcg cggtggggat gacgggatcg gcggggcggt ggtggtgcca gtcggtgacg
    22681 gattggtagg cggcggccac cgctaggagg cggtcctcgc cgtagggttt gccgccgagg
    22741 attgtgccga tggggatgcc ggcggtggtg aagccgatcg ggagagcgag ctcaggcagg
    22801 ccgagggcgt cgaacggcgt cggagaggtc tgtacgacga cgtcgcactg ctcgaacagg
    22861 tcgtccagca cccgctgcag cagcaatacc tttgcccgtt ggccgatcag gtattcgttt
    22921 gccccgagca acgcaccctg cagccagccg gtgaccgata ccccgaatcc ccgcaggtcc
    22981 gaccgcagca tcggcaggaa cggctcgctc cgctccggca gccgcacgtt gttgaacgcg
    23041 gcgttcgtga gcaggtccca ctcctccggc atcgtgacgt cgaccaccga cagcccgtcg
    23101 atccccgcga gtacgtcgag cgccgtcttc cgcgcgacgg cagtctccga ggtaccgctg
    23161 gtgaagccgg ggatgacgcc gatccgcgtg cgccagcgcg cacggacctt tccacttcgg
    23221 atcacaggag tcgcggcggt caccaggtcc ggcaccggcg gcaagccttg cgtgcgtgga
    23281 tccgcagggt cctcccccgc catcgcggtc agcatgatcg ccgcgtccat cgcgtcgcgc
    23341 gcgagcggac ccgggtgatc gcgggtgtag ctcagcggca cgatgccgtg cagcgagacg
    23401 cggcccatcg tcggcttgag gccggtcagg ttctgcgcgt tcgacggcgc cgtgatcgag
    23461 ccgcctgtct gggtgcccac actcgacgcc gccatccgcg cggcgaccgc cgttgccgag
    23521 ccggacgacg aaccacctgg atcggtgctg ggatccgccg gagtccacgc gttcaccgtg
    23581 gtgatccgcc cgtcgggcgt cgtcgcccgg gtcgttgcca acggccccat ttgggtcttg
    23641 cccaagacaa tgcctccggc cgcagtcagt cgtcgtacgg cggtcgcgtc gtacgatggg
    23701 acgaagtcgg cgaagaggta cgagttggca gtcgtggtga cgccgcgggt gtagtagttg
    23761 tccttgatcg ccagcgggat tccgtgcagt gcgccgcccc gcgaccggcc cagcgtgcgc
    23821 gcccgagcca gcgcctcgtc cgcgagtacc aggttgaacg cctgatagat cgagtcgaac
    23881 ttgccgatcc ggtccagata ggcctcgagc aactgctcag gcgtcaagcg cccctttcgg
    23941 atcagggtcg ccgcctcggc gatggtcaac tcactgacgt cgaccgatcg agccggcacg
    24001 tcgaccaacg ccgtactggt tgtcgcagga gcggcatgcg cgatcgacgg cagcgcgatc
    24061 gaacccacgg tcgtcgccgc ggccaaagca ctcgcgcgat agaggaacga ccgccggtcg
    24121 acctgctcgt ccatcggcgc actcatcgcg cctcccgggt gatgtcgatc gacgggtaga
    24181 gcttcggcgg cgcgacctgc agcgcgtcgg cgccgaagga gtacgcgctc aacggcaaca
    24241 ccgtcgtacg catgaagctc ctgagactcg cgagcaccga gtcccggcct gggctcccgg
    24301 tctccgggtc cggcgcactt cccgcgggta gttgatcgag atcgataccg atcgaggcca
    24361 gacgcgcgcg gatcatcaca tccagctccg cgtccgtggg ctgagcaagg ctcaccgaat
    24421 ccccctccag gtcgtggcgg acaaccgtca ggcctttatc tcagccaccg atttcgctga
    24481 cgtgacagcg aagtttcatc caaaggcaac cgttctccgg ctcgctgtgc ttgtgtggga
    24541 ttcgcccgat cgggtagtaa cgggagaggt agtgcacgca accatcgaca gaacggg
//
