LOCUS       NZ_SLWR01000006        22648 bp    DNA     linear   CON 05-APR-2024
DEFINITION  Kribbella antiqua strain VKM Ac-2541 Ga0310564_106, whole genome
            shotgun sequence.
ACCESSION   NZ_SLWR01000006
VERSION     NZ_SLWR01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kribbella antiqua
  ORGANISM  Kribbella antiqua
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 471678)
  AUTHORS   Whitman,W.B., Woyke,T., Klenk,H.P., Zhou,Y., Lilburn,T.G.,
            Beck,B.J., De Vos,P., Vandamme,P., Eisen,J.A., Garrity,G.,
            Hugenholtz,P. and Kyrpides,N.C.
  TITLE     Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase
            III: the genomes of soil and plant-associated and newly described
            type strains
  JOURNAL   Stand Genomic Sci 10, 26 (2015)
   PUBMED   26203337
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 471678)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 185.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004345665.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 04:15:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,825
            CDSs (total)                      :: 7,760
            Genes (coding)                    :: 7,713
            CDSs (with protein)               :: 7,713
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 7 of 47
            Pseudo Genes (incomplete)         :: 41 of 47
            Pseudo Genes (internal stop)      :: 3 of 47
            Pseudo Genes (multiple problems)  :: 4 of 47
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:43:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 440087
            Orig. end                         :: 462735
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SLWR01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22648
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..22648
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22648
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12648](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12648
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    818..832
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    1139..1150
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            2346..3338
                     /locus_tag="EV646_RS19875"
                     /old_locus_tag="EV646_106439"
     CDS             2346..3338
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012919488.1"
                     /locus_tag="EV646_RS19875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106439"
                     /product="aldo/keto reductase"
                     /protein_id="WP_132150612.1"
                     /transl_table=11
                     /translation="METRRLGRTGRDVGVVGLGAWQLGADWGEVDERDALAVLHAAVDA
                     GVTFIDTADVYGDGRSERLVGQILKETVSNGSGDLTVATKMGRRVEQIPSNYNLDAFRA
                     WNDRSRENLGVDTIDLVQLHCPPTPVYSTDAVFDALDALVDEGRIASYGVSVETCAEAL
                     TAIARPNVASIQIILNAFRLKPLDEVLPAAREAGVGIIARVPLASGLLSGKYDENTTFS
                     ADDHRTYNRHGESFDVGETFSGVDFTTGLEAVRRLIPALPTGASMAQFALRWILDQAGV
                     TVVIPGARNPAQVAANVAAADLSPLTEDQLAAVQQTYDDLIRPQIHNRW"
     gene            3432..3887
                     /locus_tag="EV646_RS19880"
                     /old_locus_tag="EV646_106440"
     CDS             3432..3887
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020573999.1"
                     /locus_tag="EV646_RS19880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106440"
                     /product="M67 family metallopeptidase"
                     /protein_id="WP_132150614.1"
                     /transl_table=11
                     /translation="MLVIEQVTYDAIVAHARRDHPDEACGVVAGPEGSDRAVRFVPMLN
                     AAMSPTFYEFDSGDLLRLYKEMDERDEEPVVIYHSHTATEAYPSRTDINLAQEPGAHYV
                     LVSTRDGADSPSYDGPVEFRSYRIIDGEVVEEEVRVVGSYQETEGES"
     gene            3891..4169
                     /locus_tag="EV646_RS19885"
                     /old_locus_tag="EV646_106441"
     CDS             3891..4169
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020387166.1"
                     /locus_tag="EV646_RS19885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106441"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_132150616.1"
                     /transl_table=11
                     /translation="MAIELRVPTILRTYTGGAKAVNGDGTTLAEFIDNVNGVHTGLKER
                     IVEGEPEELRRFVNVYVNDEDVRFTGGLKTGLKDGDVVVVLPAVAGG"
     gene            4188..5135
                     /locus_tag="EV646_RS19890"
                     /old_locus_tag="EV646_106442"
     CDS             4188..5135
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012919491.1"
                     /locus_tag="EV646_RS19890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106442"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_132150618.1"
                     /sec_met_domain="PALP (E-value: 1e-64, bitscore: 213.6,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFDSLLDSVGGTPLVGLPKLSPSADVRLWAKLEDRNPTGSIKDR
                     AALRMLLDAEKDGRLRPGNTILEPTSGNTGISLAMAAKLRGYRMVCVMPENTSEERRQI
                     LRMWGVEIISSPAAGGSNEAVRVAKQVAEEHPDWVMLYQYGNPSNAAAHYDGTAREIFA
                     DLPSVTHFVAGLGTTGTLMGAGRFFREHKPEVRIVAAEPRYGELVYGLRNLDEGFVPEL
                     YDATLIDARFSVGPRDAVRRVRELLDNEGIFAGISTGAILHAALGQAAKCVREGESADI
                     AFVVADGGWKYLSTGAYEGTIDEAEDRLEGQLWA"
     gene            complement(5163..5504)
                     /locus_tag="EV646_RS19895"
                     /old_locus_tag="EV646_106443"
     CDS             complement(5163..5504)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012919492.1"
                     /locus_tag="EV646_RS19895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106443"
                     /product="hypothetical protein"
                     /protein_id="WP_132150620.1"
                     /transl_table=11
                     /translation="MNLAHHIAVMLSTTAAPNPQPSNAAGQAADTHSTVGDIAASLGPT
                     GMLLVFGLAVFALYVISLSLHPNAKCNRCKGMGRHRGSLFSYATRPCNSCKGRGTHPRL
                     GRKVLFKQP"
     misc_feature    complement(5523..5532)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    complement(5617..5635)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.39"
                     /tool="antismash"
     gene            5706..6509
                     /gene="murI"
                     /locus_tag="EV646_RS19900"
                     /old_locus_tag="EV646_106444"
     CDS             5706..6509
                     /EC_number="5.1.1.3"
                     /GO_function="GO:0008881 - glutamate racemase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="murI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020387169.1"
                     /locus_tag="EV646_RS19900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106444"
                     /product="glutamate racemase"
                     /protein_id="WP_132150622.1"
                     /transl_table=11
                     /translation="MADAPVGIFDSGFGGLTVARAVLDQLPHEPILYLGDTARQPYGPK
                     PIAEVREYALECLDHLVEAGVKMLVIACNSASAAMLRDARERYDVPVVEVILPAARRAV
                     AATRNQRVGVICTRATAASLAYEDGFAAAPQVELFTRACPKFVDFVESGVTSGPELLEA
                     AHEYLDPLVEAGVDTLILGCTHYPLLTGVISYVMGDNVTLVSSAEECAKDVYGVLTKTG
                     LLRPDDLPAPQHRFVTTGNPAEFAAIGSRFLGPVISGVDQFAWIR"
     misc_feature    6533..6547
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     gene            6665..7411
                     /locus_tag="EV646_RS19905"
                     /old_locus_tag="EV646_106445"
     CDS             6665..7411
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020387170.1"
                     /locus_tag="EV646_RS19905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106445"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_132150624.1"
                     /transl_table=11
                     /translation="MKLTVIGCSGSLPGPDSAASSYLVTAEGFNLILDLGSGALGSLQR
                     YLAVPEIGAIGLSHLHPDHCMDLCGLYVSAKYAPESPIPRIPVFGPPDTATRMALAYDL
                     PQDPGMEEELEFHTWQEVQQIGPFTVRTAPMAHPVPAYAIRVEHGNKSLVYTGDTGPNE
                     ALIELARGADLLLSEAALQDNDPDNPPDLHMTPADAGEHAKKAGVKRLVITHVPPWFNR
                     ETQAEGARRTFPGPVELATSNAVFDI"
     misc_feature    complement(7438..7458)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     misc_feature    complement(7502..7520)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.19"
                     /tool="antismash"
     gene            7532..9061
                     /locus_tag="EV646_RS19910"
                     /old_locus_tag="EV646_106446"
     CDS             7532..9061
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="EV646_RS19910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106446"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_199237069.1"
                     /transl_table=11
                     /translation="METAPDPRRWWALGAMSVSLIVVGLDLTVLNVALPTLATELDASI
                     SQLQWFANAYTLVLAALLLPAGLLGDRFGQKWLLVGALVMFGAASAACAFATSPGQLIA
                     FRAGLGIGAAFLIPLSMSLINVLFAPEERGRAITTWVMANSLGIPLGPVLGGWLLDNYR
                     WGSIFLINVPLVVVGVVAVALLVPATRGHRSGRIDVLGIGLSGAGLVALTYGFVSAGER
                     GWGDPLTLGGIALGVVVLAAFGVWQTRAADPLVDLSLFRSREFTWGTVLATVASFALMG
                     LLFVLPQLFQAVQGVDALQTGLRLLPIIGGLLVGSKLAERLVVAMGARVTVAVGFVLMF
                     GGLAMGAFTDTGDSYGYAAIWVSVVGLSIGFTLPPVMQLATGALSTERSGAGSGLIQAL
                     RQVGGTIGVAILGTVLNSAYRDRLDVTGLPPAVADAARDSASGAVAVATKVGSPSLTES
                     ARNAFVHGMNSTLWTCCAVAVLGLLLAIAYLPRRSAVSVADGTAEVVTIKP"
     gene            9058..9654
                     /locus_tag="EV646_RS19915"
                     /old_locus_tag="EV646_106447"
     CDS             9058..9654
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037625.4"
                     /locus_tag="EV646_RS19915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106447"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_132150626.1"
                     /transl_table=11
                     /translation="MTKEKPVGLRERKKAKTRAAIQEHALRLFHEQGYAETTVQEIAAA
                     AEVSPATFFRYFPTKEDTVVFDRLDPVMIDLFRAQPPELNPTEALRATLRASLETLSED
                     EWDLESQRQQLVLNAPELRARMLDQLYAGIDLLAELAAERVGRSSDDFAVRAWAGAVIG
                     VVMATYEISGEARMPDYLRTIDQAFAHLAAGLPLS"
     gene            9741..10004
                     /locus_tag="EV646_RS19920"
                     /old_locus_tag="EV646_106448"
     CDS             9741..10004
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV646_RS19920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV646_106448"
                     /product="hypothetical protein"
                     /protein_id="WP_132150628.1"
                     /transl_table=11
                     /translation="MPIPELEELKERVQRMRDQLETVTDDEWRAYVKVRDILAFDPRFR
                     SGGPLPGVVRCAMMGIFETSEGQGTLGEYDAGAIQRFANLGE"
     gene            10001..11818
                     /locus_tag="EV646_RS19925"
                     /old_locus_tag="EV646_106449"
     CDS             10001..11818
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="EV646_RS19925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106449"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_132150630.1"
                     /sec_met_domain="YcaO (E-value: 1.8e-66, bitscore: 220.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.8e-82, bitscore:
                     271.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSPAKRGVVLIGRADALAGPVLRVPYPRERDELPAVMAGADLVV
                     AVDDGGLPVVHSWVNTVGLRLGVPTLHVALRGSRATIGPLVIPGESPCYLCWRMRALAC
                     EQDFATAMALEENLVAHREAAEQPLLPALLPMVTDAMTDVRRLSSGVLTLDAVSGAEEL
                     HPVVPRPDCPACAKHRRPVGPQDFHQAVDRLCGVVRVLEVIPKDVDEPERPYIVRAELA
                     NSHFRTATNPFVSCSGKGWTLTEARDSALGEALERYAAMTWQPERKITSTYDGLDRPGL
                     HPQQLVLFADHQYDELPFQPWRPETELEWVPAESLVTGEEVWIPLLATHLGYRPPVPLF
                     PATSNGFAAGQGKAGATLRALLEVIERDAFMIAWSHQLPGRRVAAADVPEEQVRAIAAT
                     HARRGVELMVHLLPTDTAASVALAVAWSSRAPAAVIGVAAALDPVAAARAAVLEAAQVR
                     PLLRSRLRFPAVRARMAELAASPSKVATLDDHDLLYADPSAAGLQFLRECPREPWPTKL
                     ADGNLQSLVRSVAEVAPDVLAVDVTPPDVAGVGVQVVRAVVPGFVPIWFGASQARLGGS
                     RLLEMPARIGLRSRPARLDELNLVPHPLA"
     misc_feature    10196..10198
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11830..12648
                     /locus_tag="EV646_RS19930"
                     /old_locus_tag="EV646_106450"
     CDS             11830..12648
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="EV646_RS19930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106450"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_132150632.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-26, bitscore: 88.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDHPLAWTYHRGTARSLTPEVVSTPQPGREDPTAPWIPLPPGV
                     RLDRPLAELVSDRVSCRAFGDRPISFPELATLLRIAYGATGVTDDGPLYVVDRAVPSAG
                     GLYPLELSLLVRSVDDLPAGIYHYVPLADGLELVCKGVVPASQVTYLFLDQPWAAEAAV
                     VLVLSAVCARSLVKYGDRGYRYLLLEAGHVAQNLVLAATGLDLGAVNLGGFLDDELSGL
                     LQLDSESEIVLYGVAVGRPASADRTARRALGRLVPRGLSESDGEGSHLAT"
     misc_feature    12592..12594
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12592..15537)
                     /locus_tag="EV646_RS40650"
                     /old_locus_tag="EV646_106451"
     CDS             complement(12592..15537)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="EV646_RS40650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106451"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_132150634.1"
                     /transl_table=11
                     /translation="MGGGPATRSPGIAGRVEERGILGAAIRGAAEGQPCAVFVHGEAGV
                     GKTRLVRAVCDDAVKATVLWGRCVRFGAVDSPYGPLVNALEGWVESAEPHELTEVLDAV
                     PAAGQLLPALGGHHEVRLLSVVDGLVMAIARQRPTILVVDDVQWADPASRDALAYLVAG
                     FRSQRLAILATYRDEELGTGHPMHSWLADLRRLPSVTDVRLDRLSWDETEQQVAMLLGD
                     RPRRGLVDAVVRRSDGNPYLSELLLEGVSVTADELPADLPAELSGALLAAWHRLSAPGR
                     EVMRLLAVAGRPSSIDDLREVAASAGIGPDAVTRALAEAVNTGMSVAQGADLCWFRHPL
                     VAEVLYATFVPGEAETVHAAWAKALASRPATGLDEVQRQGDLALHYEAARDLESCLEAS
                     LRAADLASGIKARREEAVHLRRAARLWPIVHGSDAEEVGLLERVARSNALVGDGEASFQ
                     AWSRALELVDERTDPLRACRLLRRWADSAFATGRTSGRPIAEAEHAVELSRAFPDSEEY
                     ADALAFLSWCQWWNNELELSGKYAEEAVQAAHRSGSNVALSLAYAVRGNADIHGERSDT
                     DTATGLRFAELTGDPELIWRMLVIRHNYLTRRGRLLECIEPIKRFLAFALDEGALSVAV
                     FAAGLLSHHLLMFGRLPESAEVIREGLSLAGLPNAGAMARLSAASLSVRQGNADVAGLH
                     VQRAEELMPGLENRTGLFAQPVLAEYLIATGRPEQALDMLSRTIGTQYVDTRDADELLV
                     WGARVAADLMEAARDRREAVGSIHAAYDELLSARRRMQPQPFELGGPDDLIQPAMQALF
                     TAETARYKAQSPTSAQWEDAVRRCDTAGLLWDEAVASLRWAQALLDEGSSRAVVAVPLR
                     SAHRFAVQAGANPLRQQVEAFAALCAIPLQEPTQPSPPETPGPLRSLTKREQEVLSYLV
                     AGRTYAEIAKALFISEKTVSVHVSNLLHKTGTSSRREVAALAVRLGQTPRN"
     gene            complement(15604..15981)
                     /locus_tag="EV646_RS19940"
                     /old_locus_tag="EV646_106452"
     CDS             complement(15604..15981)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV646_RS19940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV646_106452"
                     /product="hypothetical protein"
                     /protein_id="WP_132150636.1"
                     /transl_table=11
                     /translation="MNRKWSALALSAVAMGAVAVSATEASAGPKDPAGSSGVVLVDPPN
                     WPDEGSGYPGSGTATPEYNYPNYDPKYEVARVAPAPSASVASSSDDTAATVLQAGASAL
                     GGAGVAFGAMWLFRRHHRLAG"
     gene            complement(16136..16720)
                     /locus_tag="EV646_RS19945"
                     /old_locus_tag="EV646_106453"
     CDS             complement(16136..16720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020387176.1"
                     /locus_tag="EV646_RS19945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106453"
                     /product="hypothetical protein"
                     /protein_id="WP_132150638.1"
                     /transl_table=11
                     /translation="MLFAGSDRDGVAEGRITAAYRRWAEARVVEGRIYRTNAGRIEIDS
                     VREVNPDLIADSDADVAAADRRNAKDVRRRLRGTEEWPTFLVKFHLVEGPDPRDELAAQ
                     STLSPADLEDLKARLAKFDEFSNQGPWTTDTLRLIQSKPATRAADLAAALGRETAPFKL
                     DVRKLKNLGLTYSLEVGYELTPRGTAYLNSL"
     gene            complement(16724..17329)
                     /gene="rdgB"
                     /locus_tag="EV646_RS19950"
                     /old_locus_tag="EV646_106454"
     CDS             complement(16724..17329)
                     /EC_number="3.6.1.66"
                     /GO_function="GO:0035870 - dITP diphosphatase activity
                     [Evidence IEA]"
                     /GO_function="GO:0036222 - XTP diphosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="rdgB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020574009.1"
                     /locus_tag="EV646_RS19950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106454"
                     /product="RdgB/HAM1 family non-canonical purine NTP
                     pyrophosphatase"
                     /protein_id="WP_132150640.1"
                     /transl_table=11
                     /translation="MSKVLLASNNQKKLEELRRILTPIVPGIEVLGLGDVPPYQEPAET
                     EATFEGNALLKAHAALASTGLPSIADDSGICVDALNGMPGVLSARWAGPAKDNHANNLL
                     LLGQLEDVPDERRGASFVAAVAFVRPDGEDELVLGEMRGSVIRELRGSGGFGYDVLFQA
                     DGYDRTTAELSIEEKDAISHRGKALRALAPIVAKALGG"
     gene            complement(17326..18042)
                     /gene="rph"
                     /locus_tag="EV646_RS19955"
                     /old_locus_tag="EV646_106455"
     CDS             complement(17326..18042)
                     /EC_number="2.7.7.56"
                     /GO_function="GO:0004549 - tRNA-specific ribonuclease
                     activity [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rph"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012919497.1"
                     /locus_tag="EV646_RS19955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106455"
                     /product="ribonuclease PH"
                     /protein_id="WP_132150642.1"
                     /transl_table=11
                     /translation="MARIDGRSADQLRPVTLTRQWLDHAEGSVLVEFGRTRVLCAASVT
                     EGVPRWRKGSGLGWVSAEYAMLPRSTNTRSDRESVKGRIGGRTHEISRLIGRSLRAVID
                     YKALGENTILLDCDVLQADGGTRTAAITGAYVALADAVSWLRDRKLLKSEPLTGSVSAV
                     SVGIIDGTPMLDLCYEEDVRAETDMNLVITGEGKFIEVQGTAEGAPFDRAELDSLLELG
                     TAGCLELTKLQQEALS"
     gene            complement(18053..18880)
                     /locus_tag="EV646_RS19960"
                     /old_locus_tag="EV646_106456"
     CDS             complement(18053..18880)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012919496.1"
                     /locus_tag="EV646_RS19960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106456"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_132150644.1"
                     /transl_table=11
                     /translation="MSLHYVALGDSTTVGVGDPMNGSSTTDLSGAGARPGEGWRGWASL
                     LADALASSHRVTFSNFATSGATAPMVATEQLPETGSGPIDIASLIVGVNDTLRSTFDAG
                     RIRDCLQLCAEELTARGALLLTVRFHDHGQVFGLPSWLRRPLWQRIEQVNLAYDDLHAR
                     YGGIRLDMADYPEVYRRDFWSIDRLHPGERGHRRLARSFADELARRGLRIAVPPELDCA
                     SKPPSKWADTVWLVREGVPWLGRRAGDLTPWAARMAVSQLRPATNAEVQRVEA"
     misc_feature    complement(18927..18942)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.52"
                     /tool="antismash"
     gene            19056..20240
                     /locus_tag="EV646_RS19965"
                     /old_locus_tag="EV646_106457"
     CDS             19056..20240
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012919495.1"
                     /locus_tag="EV646_RS19965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_106457"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_132150646.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.5e-21, bitscore:
                     72.2, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 3.8e-19,
                     bitscore: 63.8, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLRFGVVGLGARSRIAQHAHQPGEGSEIVALADPVAAQRDAAR
                     EQYPDATTYADYTELLDLKLDGVFLTTPDDLHEDPAIDFLRAGVSVFVEKPLAITTTGC
                     DRVLQAAYDSGARLYVGHNMRHMPVVQTMRDLIQSGAIGEVKAIWCRHFVGHGGDYYFK
                     DWHADRRRTTSLLLQKGAHDIDVMHWLAGGYTTRANAFGGLTLYGGIEDRLDRSGQRFA
                     DFVSEDNWPPLSQTGMAPVMDVEDLSMANLLLDNGVYLTYQQCHYTPDYWRNYTVIGTA
                     GRLENFGDGPGGVVKVWNSRRSGYREDADQVVEIPDAEGGHGGADPRLVREYIRFVHEG
                     GATLTSPIAARAAVAAGYAATTSLRDNGTPIDVPPLDPALIDYFDNGQVLPSPS"
     misc_feature    20193..20195
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20382..21212
                     /locus_tag="EV646_RS19970"
                     /old_locus_tag="EV646_106458"
     CDS             20382..21212
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV646_RS19970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV646_106458"
                     /product="hypothetical protein"
                     /protein_id="WP_132150648.1"
                     /transl_table=11
                     /translation="MYPITYITDCSDGNARARLSTRIGALFGQTPTIVAADGPDPESFA
                     ALTLLDCLRSTESLGEQGFPTITLVNIAPRDGHWPNGVPFCYFHNGRHLVASTFNARVL
                     SLVRRELHISEVYLTDVREVVESAGLDNVQKIVDTQFRSLWYLPLLAKWVVDDRPVPST
                     PTAVPITTADEPTVSVIDNFGNCKFDCGPDAIGFAVGDSLPVAGRTPSGTITLTDVTCY
                     PHLTAVPEGTPGLIPGSSGTNFIELVIRGVSAAAAFGLQPGDAPLRRSSEEYAA"
     tRNA            complement(21253..21333)
                     /anticodon=(pos:complement(461385..461387),aa:Leu,seq:tag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EV646_RS19975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EV646_106459"
                     /product="tRNA-Leu"
     gene            complement(21253..21333)
                     /locus_tag="EV646_RS19975"
                     /old_locus_tag="EV646_106459"
ORIGIN
        1 acaccccgct gttcgacttc ttcgccgatg ccgaggtgtg ggggaccggc gaggcgttca
       61 aggtgatcgc ggccgagcac gtcaccaccg acgaaggtac gggcgtcgtc cacctggctc
      121 ccgcgtacgg cgaggaggac cagctcgcct gtgaagcggt cgggatcccg actctgctga
      181 ccgtcgacga tggcgcccgg ttcacgtccg tcgtgccgcc gtaccaggga atgcacgtct
      241 tcgaggcgaa ccggccgatc atccgggatc tgcgggcggc cggcgctctg gtgcgcgagg
      301 acagctacgt gcacagctat ccgcactgct ggcggtgccg gaatccgctg atctacaagg
      361 cggtgtcgag ctggttcgtc gaggtgaccc ggttccggga ccggatggtc gagctgaacg
      421 agcagatcac ctgggtgccg gagcacgtga agcacgggca gttcggcaag tggctgtcga
      481 acgcgcggga ctggtcgatc agccgcaacc ggttctgggg ttccccgatc ccggtctggc
      541 gttcggacga tccggcgtat ccgcggatcg atgtgtacgg gtcgatcgag gagttggagc
      601 gcgacttcgg cgtaccggtg cccgacctgc atcgcccgta cgtcgatcag ttgacccggc
      661 cgaatccgga cgatccgacc ggcaagtcga cgatgcggcg ggtgcccgac gtactggatg
      721 tgtggttcga ctcggggtcg atgagcttcg cgcaggtgca ttacccgttc gagaacaccg
      781 agtggttcga gcaccatttc ccgggtgact tcatcgtcga gtacatcggc cagacccgcg
      841 gctggttcta cacgctgcac atcctgtcga cggcgctgtt cgaccggccg gcgttctcgt
      901 cgtgcctgag ccacgggatc gtgctcggca gcgacgggca gaagatgagc aagtcgctgc
      961 ggaactaccc ggacgtgtcg gaggtgttcg accgggacgg cgcggacgcg atgcgctggt
     1021 tcctgatggc gagcccgatc ctgcgcggcg ggaacctggt cgtcaccgag gaaggcatcc
     1081 gcgacggggt ccggcaggtg ctgatcccgc tgtggaacgc gtggtacttc ttcgcgctct
     1141 acacgaacgc ggccgggcgc gaggcgcgtc gatcggtcga ctcaccggac ttgctcgatc
     1201 ggtatctgct ggccaagctg cgggtgttcg tcaatgaggt gcaggggcgg ctggatcggt
     1261 acgagatcgc gtcggcgtgc gagtcggtcc tgggctatgt cgaggtgctg acgaactggt
     1321 acatccggcg atcgcgggac cgcttttggg cgggctcggc ggaggcgatc gacacgctct
     1381 acaccgcgct cgagacggtg gcgcggacgg tggcgccgct gcttccgctg acggcggagg
     1441 agatctggcg cggtctgacc ggtgggcggt cggtgcatct gacggactgg ccggtcgttg
     1501 aggacctgcc ggacgatccg gagctggtgg cgcggatgga tcgggttcgt gaggtgtgct
     1561 cggtcgcgtc gtcgatccgt aaagcatccg gtatccgtgg ccggcaaccg ttgcagtcgt
     1621 tgacggtggc aacggtcgac gcctcggggt tgcgggctct ggtgccgttg atccaggccg
     1681 aggtcaacgt ccgggacgtc gtactcgcgt cggtcgatga agtggacgcg ccggtgtcgc
     1741 agcggctgac ggtgaacgcg cgggcggcgg ggccgcgact cgggcgggac gtccagacgg
     1801 tgatcaaggc gtcgaagtcg ggcgactggt ctgctgtgga cggccgcgtt attgccgggg
     1861 gcatcgagtt ggccgaggat gagtacacgt tggagacgac ccttgccgag ggcggtacgg
     1921 cgagtgggct gctgagcggc ggcgggttcg tcgtactgga caccacgatc acgcctgagt
     1981 tgacggccga ggggacggcg cgggacgtgg tccgcgccgt gcagcaggca cgacgcgatg
     2041 ccggcctgga ggtggccgac cggatgcggc tctctttgac cgcctctccg gacgtgctcg
     2101 cggcggtcga ggcgcatcgc gacctgatca tggacgagac actggctgtc ggcgtcgcgg
     2161 ttgccgaagg cccggagcta accgtgacca ttgagcgagc gtcccactag ccgaccggtt
     2221 ccaaggacct gcggtccgtt gtggcgtccg tacttgccga gcagggtcgg cctgttggtc
     2281 tggggagttc tgctaccgag ggacttggcg agtggtggga gtccgcgtgg gggagactgg
     2341 gcgccatgga gacgcggagg cttggtcgga ctgggcggga cgttggggtt gtcgggctgg
     2401 gtgcctggca gcttggggcg gactggggtg aggtggacga gcgcgatgcg ctcgcggtac
     2461 tgcatgccgc cgtcgacgcc ggtgtcacgt tcatcgacac cgcggatgtg tacggcgacg
     2521 gccgcagcga acggttggtg ggtcagatcc tgaaggagac tgtgtccaac ggatctggcg
     2581 atctgaccgt ggcgacgaag atgggtcgcc gggtggagca gatcccgtcg aactacaacc
     2641 tcgacgcgtt ccgcgcctgg aacgaccgat cccgggagaa cctcggcgtc gacaccatcg
     2701 acctggtcca gttgcactgc ccgccgaccc cggtgtactc gaccgacgcg gtcttcgacg
     2761 cgctcgacgc cctggtcgac gagggccgca tcgcgtcgta cggggtgtcg gtcgagactt
     2821 gcgccgaggc gctgaccgcg atcgcgcgcc cgaacgtggc gtcgatccag atcatcctca
     2881 acgccttccg gctgaagccg ctcgacgagg tgctcccggc cgcccgcgag gccggcgtcg
     2941 gcatcatcgc ccgcgtcccc ctcgccagcg gtctgctgtc cggcaagtac gacgagaaca
     3001 ccaccttctc ggccgacgac caccgcacgt acaaccgcca cggcgagtcc ttcgacgtcg
     3061 gcgagacgtt ctccggcgtc gacttcacca ccggcctcga agccgtccgc cgcctcatcc
     3121 ccgcgctccc caccggcgcc agcatggccc aattcgccct ccgctggatc ctcgaccagg
     3181 ccggcgtaac cgtcgtcatc cccggcgccc gcaacccagc ccaagtagcc gccaacgtcg
     3241 ccgccgccga cctatcgccc ctcaccgaag accaactcgc cgccgtccag cagacctacg
     3301 acgacctgat ccgcccccag atccacaacc gctggtaagc gcgaccgaag ccaccgtgct
     3361 gcgccattcc agtatgcgga cagacctggc ggtcgtcagg gggacgtcgg gctggcatct
     3421 acggttgtgg tgtgttggtg atcgaacagg tgacgtacga cgcgatcgtc gcgcacgctc
     3481 ggcgggatca tccggatgag gcgtgtgggg tggttgcggg gccggagggg tccgatcggg
     3541 cggtgcggtt cgtgccgatg ctcaatgcgg cgatgtcgcc gacgttctac gagttcgact
     3601 cgggggatct gctccggttg tacaaggaga tggacgagcg ggacgaggag ccggtggtga
     3661 tctaccactc ccacaccgcg accgaggcct atccgtcccg caccgacatc aacctggcgc
     3721 aggagcccgg cgcgcactac gtgctggtgt cgacgcgcga cggcgcggac tcaccgtcgt
     3781 acgacgggcc ggtcgagttc cgctcgtacc ggatcatcga cggcgaggtc gtggaagaag
     3841 aagtgcgcgt ggttggttct tatcaggaaa cagaaggaga gagctgagat atggcgatcg
     3901 agctgcgcgt gccgacgatc ttgcgcacgt acaccggcgg agcgaaggcg gtgaacgggg
     3961 acggcaccac gctggccgag ttcatcgaca acgtgaacgg cgtccacacc ggactcaagg
     4021 agcgcatcgt cgagggtgag ccggaggagc tgcgccggtt cgtcaacgtc tacgtgaacg
     4081 acgaggacgt ccgtttcacc ggtgggctga agaccggcct gaaggacggc gacgtggtcg
     4141 tcgtactgcc tgccgtcgcc ggcggctgac cacaaaaagg actgacgatg cgtttcgaca
     4201 gcctgctgga ctcggtcggc ggtacgccgc tggtcgggct gcccaagctg tccccgtcgg
     4261 ccgacgtacg gctgtgggcc aagctggagg accgcaaccc gaccggctcg atcaaggacc
     4321 gggccgcgct ccggatgctg ctcgacgccg agaaggacgg ccggctgcgg cccggtaaca
     4381 ccatcctcga gccgacctcg ggcaacaccg gtatctcgct cgcgatggcg gccaagctgc
     4441 gcggctaccg gatggtctgc gtgatgccgg agaacacctc cgaggagcgc cggcagatcc
     4501 tgcggatgtg gggtgtcgag atcatctcct ccccggccgc gggtggttcg aacgaggccg
     4561 tccgggtggc caagcaggtc gcggaggagc accccgactg ggtgatgctc taccagtacg
     4621 gcaacccgtc gaacgcggcc gcgcactacg acggcaccgc gcgcgagatc ttcgccgacc
     4681 ttccctccgt cacccacttc gtcgccggcc tcggcaccac cggcacgctg atgggcgcgg
     4741 gccgcttctt ccgcgagcac aagcccgagg tccggatcgt cgcggccgaa ccccggtacg
     4801 gcgaacttgt ctatggtctg cgcaacctcg acgaaggctt cgtgccggag ttgtacgacg
     4861 cgaccctcat cgacgcgcgg ttctccgtcg ggccgcgaga cgcggtccgc cgggtccgcg
     4921 aactgctcga caacgaaggc atcttcgccg gtatctccac cggcgcgatc ctgcacgccg
     4981 cgctcgggca ggcggcgaag tgtgtccggg agggcgagtc cgcggacatc gcgttcgtcg
     5041 tcgccgacgg cggctggaag tacctgtcga ccggtgccta cgagggcacc atcgacgagg
     5101 cggaggaccg cctcgaaggc caattgtggg cctgaatccc cgttgtttta cgtcatctcc
     5161 gcctacggtt gcttgaacag gaccttgcgt ccgagtcgtg ggtgggtgcc acggcccttg
     5221 cagctgttgc aggggcgagt ggcgtagctg aacagcgaac cccggtgccg tcccatgccc
     5281 ttgcaccggt tgcacttggc attcgggtgc agggacagcg agatgacgta cagggcgaag
     5341 accgccaggc cgaacaccag cagcatcccg gtgggaccca gggatgcggc gatgtctccg
     5401 acggtgctgt gcgtgtccgc agcctgacca gcagcgttgc tcggttgcgg attcggagcg
     5461 gcggtggtgc tcagcatcac cgcgatgtga tgcgccaggt tcatggcgtc acagggggcg
     5521 gttcaagaaa catcgctcca gagtggcgcg cgtcacgcga aaaggcaact ccagagagta
     5581 aagatgtgga taaccccggc gtgtcgtttc gctgacttag gcaagcctcc cttcaacact
     5641 gcccgaagcc ggacttgtcc acagccgcgt acgggcgatc gtcgtacgcc ggataagctt
     5701 cagccgtggc ggatgcaccg gtggggatct tcgattcggg gttcgggggg ctcacggtcg
     5761 cccgggcggt gctcgatcag ttgccgcacg agccgatcct gtacctcggt gacactgcgc
     5821 gacagccgta cgggcccaag ccgatcgcgg aggtccgcga gtacgcgctc gaatgcctcg
     5881 accacctggt cgaggccggc gtgaagatgc tcgtgatcgc ctgcaactcc gccagtgcgg
     5941 cgatgctgcg ggatgcccgc gagcggtacg acgtacccgt ggtcgaggtg atcctgcccg
     6001 ccgcccgccg agccgtcgcc gcgacgcgga accagcgcgt cggtgtgatc tgcacccgcg
     6061 cgaccgcggc ctcgctcgcc tacgaggacg ggttcgccgc cgcgccgcag gtcgagctgt
     6121 tcacccgcgc ctgcccgaag ttcgtcgact tcgtcgagtc cggcgtgacg tccggtcccg
     6181 aactgctcga ggccgcgcac gagtacctag acccgctggt cgaggccggc gtcgacacgc
     6241 tgatcctcgg ctgcacgcac tacccgttgc tcaccggcgt catctcgtac gtgatgggtg
     6301 acaacgtcac cctggtcagc agcgccgagg agtgcgcgaa ggacgtgtac ggcgtcctca
     6361 ccaagaccgg gctgctccgg ccggacgacc tgccggcgcc gcagcaccgg ttcgtcacca
     6421 ccgggaaccc ggccgagttc gccgccatcg gctcccgctt cctcggtccg gtcatctccg
     6481 gcgtcgacca gttcgcctgg atccgctgag ccatggtgtt gcggccggcc aacgaacatc
     6541 gttgtcatcg gcaccgggtc cggacggaac gtgggcgaaa tcactgccag gcaaccgaat
     6601 ccgccgctcc gtggcgccac cggcattcct gcgaaggcgg caacccgccg gtaatgttcc
     6661 agctatgaag ctcaccgtga tcggttgctc cgggtcgctc cccgggccgg actcggccgc
     6721 ctcgagctat ctggtcacgg ccgaggggtt caacctgatc ctcgacctcg gcagtggcgc
     6781 gctcggctcg ctccagcggt atctcgccgt acctgagatc ggcgcgatcg gcctgtccca
     6841 cctgcatcct gatcattgca tggatctgtg cggcctctac gtctcggcca agtacgcacc
     6901 tgagtcaccg atcccgcgga tccccgtctt cggtccgccc gacacggcga ccaggatggc
     6961 gctggcctac gacctgccgc aggatccggg catggaggag gagctggagt tccatacctg
     7021 gcaggaagtt cagcagatcg ggccgttcac cgtccggacc gcgccgatgg cgcatccggt
     7081 cccggcgtac gcgatccgcg ttgagcatgg caacaaatcg ctcgtctaca ccggcgacac
     7141 cggcccgaac gaggcgctga tcgaactggc ccgcggcgcc gacctgctgc tgtccgaggc
     7201 ggcgttgcag gacaacgacc cggacaaccc gcccgacctg cacatgactc ccgccgacgc
     7261 cggcgaacac gcgaagaagg ccggcgtcaa acgcctcgtc atcactcacg tgccgccgtg
     7321 gttcaaccgc gagacccagg ccgaaggcgc ccgccgcacc ttccccggcc cggtcgagct
     7381 cgccacctcg aacgcagtct tcgacatctg acctgccgca tcagcgccgg tacgacgtga
     7441 tcgtcgtacc ggcgctttgt tgtgcgggct ggacatttcg agattctgag atctactcta
     7501 atttgagagt tgctctcaga aaggattcgt gatggagacc gcacccgacc cgcgccggtg
     7561 gtgggcgctg ggagccatgt ccgtcagcct gatcgtggtc ggactggatc tgaccgtgct
     7621 caacgtggcg ctgccgacgt tggcgaccga gctggacgcg tcgatcagtc agctgcagtg
     7681 gttcgcgaac gcgtacacgc tggtcctcgc ggcgctgctg ctgccggccg ggttgttggg
     7741 ggaccggttc gggcagaagt ggttgctggt cggggcgctg gtgatgttcg gggcggcgtc
     7801 ggcggcgtgt gcgttcgcga cgtcgccggg ccagttgatc gcgttccgcg ccgggctcgg
     7861 gatcggggcg gcgttcctga tcccgttgtc gatgtcgctg atcaacgtgc tgttcgcgcc
     7921 ggaggagcgc ggccgcgcga tcacgacgtg ggtgatggcc aactcgctcg gcatcccgct
     7981 gggaccggtg ctcggcggct ggctgctgga caactaccgc tggggatcga tctttctgat
     8041 caacgtgccg ctggtggtgg tcggtgtagt ggccgtggcg ctgcttgttc cggcgactcg
     8101 tggtcaccgg tccgggcgga tcgacgtact gggaatcggg ctgtcggggg cggggctggt
     8161 ggcgctcacg tacgggttcg tgtcggctgg ggagcgtgga tggggtgatc cgttgacgct
     8221 cggcgggatc gcgctcggcg tggtggtgct ggccgcgttc ggcgtgtggc agacgcgtgc
     8281 tgcggatccg ttggtggacc tgagtctgtt caggtcgcgc gagttcacct ggggcacggt
     8341 gctggcgacc gtcgcgtcgt ttgcgctgat ggggttgctg ttcgtgttgc cgcagctgtt
     8401 ccaggcggtc caaggggtcg acgccctgca gacggggctg cggttgctgc cgatcatcgg
     8461 tggtctgctg gtcgggtcca agctggctga gcggctcgtc gtcgccatgg gcgctcgcgt
     8521 gactgtggcg gtcgggttcg tgctgatgtt cggtggtctc gcgatgggcg ccttcaccga
     8581 cacaggcgac agctacggct acgcggcgat ctgggtgagc gtggtcgggc tcagcatcgg
     8641 attcacgctg cctccggtga tgcagctggc gaccggggcg ttgagcaccg aacgcagtgg
     8701 agcgggctcc ggcctgatcc aggcgttgcg ccaggtcggc ggcacgatcg gggtcgcgat
     8761 cctcggcacg gtgctgaact cggcgtaccg ggacaggctg gacgtcaccg gcctgccgcc
     8821 cgcggtcgcc gacgcggccc gggacagcgc gtccggcgca gtcgctgtcg cgacgaaggt
     8881 cggctcgccg tcgctcaccg agtccgcccg aaacgccttc gtgcacggca tgaactcgac
     8941 gctgtggacc tgttgcgcgg tcgccgtact cggcctgctg ctcgccatcg cctacctccc
     9001 gcgccgctcg gccgtgtcag tcgccgacgg tacggcggaa gttgtcacaa tcaagccatg
     9061 acgaaggaga agccggtcgg gctgcgcgaa cggaagaagg cgaagacccg ggcggccatc
     9121 caggagcacg cactgcggct gttccacgag caggggtatg ccgagacgac ggtgcaggag
     9181 atcgcggccg cggccgaggt gtcgccggcg acgttcttcc ggtacttccc gaccaaggag
     9241 gacaccgtcg tcttcgaccg gctcgacccg gtgatgatcg acctcttccg ggcccagccg
     9301 cccgagctga acccgaccga ggccttgcgg gcgactctcc gggccagcct cgagaccttg
     9361 tccgaggacg agtgggacct ggaatcccaa cgccagcagc tcgtcctcaa tgctcctgaa
     9421 ctccgggccc ggatgctcga tcagctgtac gccggcatcg acctgctcgc cgaactcgcc
     9481 gccgaacgcg tcggccgatc gtctgacgat ttcgccgtac gagcgtgggc cggcgcagtc
     9541 atcggcgtgg tgatggcgac gtacgagatc agcggggagg cccggatgcc ggactacctc
     9601 cggaccattg accaagcctt cgcccacctc gccgccggcc tgccgctgtc ttagaagaac
     9661 ccgcggaggc tctccgcgac gacttgggtt gacaccacat cgcagcggtc gatactcgaa
     9721 gaaggtgggg agggggagct atgccgattc cggagctgga ggaactcaag gagcgggtcc
     9781 agcgcatgcg ggaccaactg gagacggtga cggacgacga gtggcgggcc tacgtcaaag
     9841 tccgcgacat cctcgcgttc gacccgaggt tccggtccgg tggtccgctg ccgggcgtgg
     9901 tgcgctgcgc gatgatgggc atcttcgaga cttccgaggg gcaggggacc ctcggcgagt
     9961 acgacgccgg cgccatacag cggttcgcaa accttggcga atgaactccc cagcaaagcg
    10021 aggggttgtt ctcatcgggc gcgcggatgc gctggccggc cctgtactac gagtgccgta
    10081 cccgcgggag cgtgacgaac tgccggcggt gatggccggt gcggatctcg tcgttgcggt
    10141 cgatgacggt gggcttccgg tcgtccattc gtgggtcaac acggtcgggc tgcgattagg
    10201 tgtgccgacg ctgcacgtcg cgctgcgtgg ctcgagggca accatcggtc cgctggtgat
    10261 ccccggcgag agcccgtgct acctctgctg gcggatgcgc gcgctggcct gcgaacagga
    10321 cttcgctacg gcgatggccc tcgaggagaa tctcgttgcc caccgggagg ccgcggagca
    10381 accgctgctg ccggccctgc tgccgatggt gaccgacgca atgaccgacg tacggcggtt
    10441 gtccagtggt gtgctgactc tcgacgcggt gagcggcgcc gaggagctgc atccggttgt
    10501 gccacgcccc gactgcccag cgtgcgcaaa gcaccgccgg ccggtcggac ctcaagactt
    10561 ccaccaagcg gtcgatcgac tctgcggcgt cgtccgcgtg ctggaggtga taccgaaaga
    10621 cgtcgacgag cccgagcggc cgtacatcgt ccgcgccgag ctggcgaact cccacttccg
    10681 cacagccacc aaccccttcg tgtcctgctc gggcaagggc tggacgctga ccgaggcacg
    10741 cgacagcgcg ctcggcgagg cccttgagcg ctacgccgcg atgacctggc aacccgagcg
    10801 caagatcact tcgacgtacg acggactgga ccggcccggg ctgcatccgc aacagctcgt
    10861 gctgttcgcc gaccatcagt acgacgagct gccgtttcag ccgtggcggc cggaaaccga
    10921 gctcgaatgg gtgcccgcag agtcgttggt gacgggagag gaggtctgga tccccttgct
    10981 ggcaacgcat ttgggctacc ggccgccggt cccgttgttc cccgccacct cgaacgggtt
    11041 cgcggccggc cagggcaagg ccggcgcgac gctgcgagcg ttgctcgagg tgatcgagcg
    11101 ggacgctttc atgatcgcct ggtcgcatca gctgcccggc cgacgcgtgg cggccgccga
    11161 cgtcccggaa gaacaggtac gcgcgatcgc cgcgacccat gcacggcgtg gcgtcgagct
    11221 gatggtgcat ctgctcccga cagacaccgc agcgtccgtc gccctcgccg ttgcatggtc
    11281 ctcccgggca ccggccgccg tgatcggggt cgccgccgcg ctggacccgg ttgctgccgc
    11341 gagggccgcc gtactggagg cagcgcaggt gcgcccgctg ctgcgcagcc gactccggtt
    11401 ccccgctgtc cgggcgcgga tggccgagct ggcagcctcg ccgtccaagg ttgcgacgct
    11461 tgacgaccac gatttgctgt acgccgaccc gtccgccgcc ggactgcaat tcctccgcga
    11521 gtgtccgcgc gagccgtggc cgacaaaact tgctgatggc aaccttcagt cgctggtccg
    11581 atcagtcgcc gaggtggcgc cggacgtact cgcggtggat gtcacgccgc cggatgtcgc
    11641 cggtgtgggg gtccaggtgg tgcgcgctgt ggtgccaggg ttcgtgccga tctggttcgg
    11701 tgcgagtcag gcgaggctcg gcggatcccg cttgctggag atgccggccc ggatcgggct
    11761 gcgatcgcgg cccgcgcggc tggacgagct caatctcgtg ccgcacccac tcgcgtaagg
    11821 aacagcccga tgaccaccga tcatccgttg gcctggacct accatcgagg caccgctcgg
    11881 tcgttgaccc ctgaggtggt ctcgacgccg cagccagggc gggaggaccc gactgcaccg
    11941 tggatccctt tgccgccggg ggtacggctc gacaggccat tggccgaatt ggtcagcgac
    12001 cgtgtgtcgt gccgcgcgtt cggcgaccgg ccgatcagct tcccggagct cgccacgctg
    12061 ctaaggatcg cgtacggcgc caccggcgtg accgacgacg gcccgctcta cgtggtcgac
    12121 cgagcggtgc cgtccgccgg agggctgtac ccactcgaac tcagcctcct tgtgcgctca
    12181 gtcgacgatc tgcccgccgg gatctaccac tacgtgccac tcgcagacgg ccttgagttg
    12241 gtctgcaagg gcgtcgtacc ggcgtcgcaa gtcacgtacc tgttcctgga ccagccatgg
    12301 gcggccgagg cagccgtcgt actggtgctg tccgccgttt gtgcgcgcag cctggtcaag
    12361 tacggcgacc gcggctaccg ctacctgttg ctggaagcgg ggcacgtggc gcagaacctt
    12421 gtcctggcgg cgaccgggct cgacctggga gccgtcaatc tcggtggctt cctcgatgac
    12481 gaattgtcgg ggttgctgca gctcgacagc gagtccgaga tcgttctgta cggcgtggca
    12541 gtcggccgac cggcgtccgc cgaccgcacc gcccgccgcg cgctcggccg gttagttcct
    12601 cggggtttgt ccgagtctga cggcgagggc agccacctcg cgacgtgacg acgtcccggt
    12661 tttgtgcagc aggtttgaca cgtgcacgct gaccgtcttc tcgctgatga agagcgcctt
    12721 ggcgatctcg gcgtacgtcc ggccggccac gaggtaggac agcacctcct gctcgcgctt
    12781 cgtcagcgaa cgcagcggcc ccggggtctc cggtggcgac ggttgggtcg gctcctggag
    12841 cggaatggcg cagagagcgg cgaacgcctc gacctgctgc cgcaagggat tcgcgccggc
    12901 ctggaccgcg aaccgatgcg cggacctcag cggtacggcg acaacggctc gtgagctgcc
    12961 ctcgtcgagc aacgcctggg cccaccggag ggaggcgacc gcttcatccc acagcagtcc
    13021 cgccgtgtca catcgccgta cggcgtcctc ccactgcgcg gaggtgggcg actgagcttt
    13081 gtaccgcgcg gtctccgccg tgaacagcgc ctgcatcgcc ggttggatca ggtcgtcggg
    13141 cccgccgagc tcgaagggct gcggctgcat ccgccggcgc gctgacagaa gttcgtcgta
    13201 cgccgcgtgg atcgatccga cggcttcacg gcggtcccgg gcggcctcca tcagatcggc
    13261 tgcgacgcgt gctccccaga cgagcagctc atcggcgtcg cgagtatcga cgtactgcgt
    13321 gccgatcgtt cgcgacagca tgtcgagggc ctgctcgggg cggccggtgg cgatcaggta
    13381 ctcggccagg acaggctgcg cgaagaggcc cgttcggttc tcgagtcccg gcatcagctc
    13441 ctcggcgcgc tgcacgtgca ggcccgcgac gtccgcgttt ccctgccgca ccgacaacga
    13501 ggccgcgctc agccgggcca tggcgccggc gttcgggaga ccggccaggg acaggccttc
    13561 gcggatgacc tcggcgcttt ccggcaagcg tccgaacatc aggaggtgat gggacagcag
    13621 gccggcggcg aagaccgcga ccgacagtgc tccttcgtcg agggcgaagg cgagaaatcg
    13681 tttgatcggc tcgatgcatt ccagcagtcg gccacgacgg gtcaggtagt tgtggcggat
    13741 caccagcatc cgccagatga gttccggatc gccggtgagc tcggcgaatc gcaggccggt
    13801 ggcggtgtcg gtgtcggagc gctcgccgtg aatgtcggcg ttcccgcgga cggcgtacgc
    13861 cagactgagc gccacgttgg atcccgaccg atgagccgcc tgcaccgcct cctcggcgta
    13921 cttcccggac agctcgagtt cgttgttcca ccactgacac cagctgagga acgccagtgc
    13981 gtcggcgtac tcctcgctgt ccggaaacgc ccggctcagc tcgaccgcgt gctcggcctc
    14041 ggcgatcggt cgcccgctgg ttcggccggt cgcaaaggca gagtccgccc atcgccgcag
    14101 cagccggcag gcccgcaggg gatcggtacg ctcgtcgacg agttcgagcg cgcggctcca
    14161 cgcctggaag ctggcctcgc cgtcgccgac cagggcgttg gatcgcgcga cccgctccag
    14221 caggccgacc tcctcggcgt cactgccgtg gactatcggc cacaagcgtg ccgcgcggcg
    14281 gagatgaacg gcctcctcgc gccgggcctt gatcccgctc gcgagatcag ctgctcgcag
    14341 cgacgcctcg agacaggatt cgaggtcacg cgcggcctcg taatgcagcg caaggtcgcc
    14401 ttgccgctgg acctcgtcga ggcccgtcgc cgggcgcgac gcgagcgcct tggcccacgc
    14461 ggcatgcact gtttccgcct cgccggggac gaaggtcgcg tacagaacct cggcgaccaa
    14521 cgggtgccgg aaccagcaca agtccgcacc ctgcgccacg ctcatccctg tgttcaccgc
    14581 ctcggccagc gcacgcgtca ccgcatcagg accgatcccg gccgatgcgg cgacctcccg
    14641 cagatcgtcg atcgacgacg gccgacccgc gaccgccagc agccgcatga cctcacgccc
    14701 cggcgccgac agccggtgcc aggccgcgag caaggctccc gacagctcgg ccggcaaatc
    14761 agcgggcagt tcgtcggcgg tcacgctcac tccctcgagg agcagttcac tgagataggg
    14821 attgccgtcg gaccgccgta cgacggcatc cacgagcccg cggcgaggac gatcacccag
    14881 cagcatcgcg acctgttgct cggtctcgtc ccagctcagc cggtccagcc gtacgtcggt
    14941 caccgacggg agccggcgca gatccgccag ccagctgtgc atcgggtgac cggtgccgag
    15001 ttcctcatcg cgatacgtcg ccagaatcgc cagccgctgg ctgcggaacc cggcgaccag
    15061 ataggcgagc gcgtcgcggg aggccggatc ggcccactgc acgtcgtcga cgaccagaat
    15121 cgtcggccgc tgcctggcga tcgccatcac caagccgtcg acgactgaca ggagccggac
    15181 ctcatggtga ccgcctagcg ccggcaacag ctgacccgcg gcgggaacgg cgtcgagtac
    15241 ctcggtcagt tcatggggct cggccgactc gacccagccc tccaacgcgt tgaccagcgg
    15301 accgtacggc gaatcgaccg cgccgaagcg gacacaccga ccccacaaga cggtggcttt
    15361 cacggcgtcg tcacagacgg ctctgaccag acgggtcttg cccacgccgg cctcgccgtg
    15421 cacgaagacc gcacatggtt gtccttcggc ggctccccgg atcgccgctc ccaggattcc
    15481 ccgttcctcg acgcgaccgg cgataccggg tgagcgggtg gctggtcccc ctcccacatc
    15541 acccagtctg cacccgctgt ccggcgcacg gcagcacgcc gggcagcggg caccccctcc
    15601 tgactagccg gccagccggt ggtggcggcg gaacagccac atcgcaccga aggcgactcc
    15661 ggcaccaccg agggcggagg caccagcctg cagcacagtc gcagcggtgt cgtccgacga
    15721 gctcgccacc gaggcagacg gcgccggggc cacacgagcc acttcgtact tagggtcgta
    15781 gttcgggtag ttgtactccg gggtcgcagt accggaccct gggtagccgg agccttcgtc
    15841 cggccaattg ggcggatcca ccagcacgac ccccgacgat cctgccgggt ccttcggacc
    15901 ggccgatgcc tcagtcgcgc tgacggcgac ggcacccatc gcgactgcgg acagtgcgag
    15961 agctgaccac ttgcggttca tgattcctcc agtgagacct gcggccgaat cgccgcttgc
    16021 tctcaccgtc agccctcacc ccacccaccc acatcgcaac caacccctca gaacccccgc
    16081 aaaacccctc agatcatgat cacgcttccg tttgcgccca ggccggacgg taggttcaga
    16141 gcgagttcag gtaggccgtg ccgcgcgggg ttagttcgta gccgacctcg aggctgtagg
    16201 tgaggcccag gtttttcagt ttgcggacgt ccagtttgaa gggggcggtt tcgcggccta
    16261 gggcggcggc caggtcggcg gctcgggtgg cgggtttgga ttggatcagg cggagggtgt
    16321 cggtggtcca ggggccctgg ttgctgaact cgtcgaactt cgccagccgg gccttgaggt
    16381 cctcgaggtc ggcgggtgac aaggtcgact gggcggcgag ttcgtcgcgg gggtcggggc
    16441 cttcgaccag gtggaacttg accaggaagg tcggccactc ctcggtgccg cgcaggcggc
    16501 ggcggacgtc cttggcgttg cggcggtccg cggcggcgac gtcggcgtcg ctgtcggcga
    16561 tcaggtccgg gttgacctcc cggacgctgt cgatctcgat ccggccggcg ttggtgcggt
    16621 agatccgccc ctcgaccacc cgggcctcgg cccagcgccg gtacgccgcg gtgatgcggc
    16681 cctcggcgac gccgtcgcga tccgatccgg cgaacaacat ggtctagcct cccagcgcct
    16741 tcgcgacgat cggggccagc gcgcgcaacg ccttgccccg gtgactgatc gcgtccttct
    16801 cttcgatcga cagttccgcc gtggtccggt cgtacccgtc ggcctggaac agtacgtcgt
    16861 acccgaaacc gccggagccg cggagctcgc ggatgaccga gccgcgcatc tcgccgagga
    16921 cgagctcgtc ctccccgtcc gggcggacga acgcgacggc tgcgacgaac gaggcgccgc
    16981 gccgctcgtc cggcacgtcc tccaactgcc cgagcagcag caggttgttc gcgtggttgt
    17041 ccttcgccgg cccggcccag cgcgcggaca gtacgccggg catcccgttc agcgcgtcga
    17101 cgcaaatgcc gctgtcgtcc gcgatcgacg gcaacccggt cgacgccagc gccgcgtgcg
    17161 ccttcagcaa cgcgttgccc tcgaacgtcg cttccgtctc ggccggttcc tggtacggcg
    17221 gtacgtcgcc gagcccgagc acctcgatcc cagggacgat cggggtcagg atccggcgca
    17281 gctcctcgag cttcttctgg ttgttcgagg caagcaacac cttgctcacg acaacgcctc
    17341 ctgctgaagc ttggtcagct ccaggcatcc cgccgtaccg agctccaaga ggctgtccag
    17401 ctcggcgcgg tcgaacggcg cgccctcggc ggtgccctgc acctcgatga acttgccctc
    17461 gccggtgatc accaggttca tgtcggtctc ggcccggacg tcctcctcgt agcagaggtc
    17521 gagcatcggg gtgccgtcga tgatgccgac cgagaccgcg gacaccgagc cggtcagtgg
    17581 ctcgctcttc agcagcttgc ggtcgcgcag ccagctcacg gcgtcggcga gggcgacgta
    17641 cgcgccggtg atcgcggcgg tccgggtgcc gccgtcggcc tggaggacgt cgcagtccag
    17701 caggatggtg ttctcgccga gcgccttgta gtcgatcacg gcccgcagcg aacgcccgat
    17761 cagccgggag atctcgtgcg tccggccgcc gatccggccc ttcaccgatt cgcggtcgga
    17821 gcgggtgttg gtcgatcgcg gcagcatcgc gtactccgcg ctgacccagc cgagcccgga
    17881 gcccttccgc caccgcggca cgccctcggt cacactcgcc gcacacagca cccgggtccg
    17941 gccgaactcg accagcaccg acccttcggc gtggtcgagc cactgccgcg tcaaggtcac
    18001 cggccgaagc tgatccgcac tacgtccatc gatacgagcc atgcctcaga ccctatgcct
    18061 cgacgcgctg cacctccgca ttggtcgccg ggcgaagctg gctcacggcc atccgggctg
    18121 cccacggagt caggtcgccg gcccgtcgcc cgagccacgg cacgccttcg cggaccagcc
    18181 acaccgtgtc cgcccacttg ctcggcggct tggacgcgca gtccagttca ggcggtacgg
    18241 cgatccgcag cccgcgccga gccaactcgt cggcgaacga gcgcgccagc cgacgatgcc
    18301 cgcgctcacc cggatgcagc cggtcgatac tccagaagtc ccgccggtag acctctgggt
    18361 agtcggccat gtccagccgg atcccgccgt acctcgcgtg cagatcgtcg tacgcgaggt
    18421 tgacctgttc gatgcgctgc cacagcggcc ggcgcagcca ggacggcagg ccgaagacct
    18481 gaccgtgatc gtggaagcgg acggtgagca gcagggcgcc gcgggcggtc agttcctcgg
    18541 cgcacagctg caggcagtcg cggatccggc cggcgtcgaa cgtggagcgc agggtgtcgt
    18601 tgacaccgac gatcagcgag gcgatgtcga tcggaccgga gccggtctcg ggcagttgct
    18661 cggtcgcgac catcggcgcc gtcgcaccgc tggtcgcgaa gttggagaac gtcacacggt
    18721 gggagctggc cagggcatcg gcgagcagcg aggcccagcc tcgccaccct tcgcccgggc
    18781 gcgcgccggc accggagagg tcggtcgtac tgctgccatt catcgggtcc ccgacaccca
    18841 cggtggtcga gtcccccagt gccacatagt ggaggctcac attccgccat ggtgaccgga
    18901 ccggtcgagc cgccggtgtt gcctgggtga ccactcggtc aacaccggac gatcactagg
    18961 tgccaccggc gctcgatccc acctggaggg atgggcattg agtggcggaa atgctcggag
    19021 ttagtgtgtt gcaaacaact atgtgcagga gcgaaatgac tgacctacgg ttcggtgtgg
    19081 tgggactcgg cgcccggagc cgcatcgcgc agcacgcaca tcagcccggc gaagggtccg
    19141 agatcgtcgc tctcgccgac ccggtcgcgg cccaacggga cgcggcgcgg gagcagtacc
    19201 cggacgcgac gacgtacgcc gactacaccg agctgctcga cctgaagctg gacggtgtct
    19261 tcctgaccac cccggacgac ctgcacgagg atccggcgat cgacttcctc cgggccgggg
    19321 tttcggtgtt cgtggagaag ccgctggcga tcacgacgac cggctgcgac cgggttctcc
    19381 aggcggcgta cgacagtggg gcccggctgt acgtcggcca caacatgcgc cacatgcccg
    19441 tcgtacagac gatgcgggat ctcatccagt ccggcgcgat cggtgaggtg aaggcgatct
    19501 ggtgccggca cttcgtcggc cacggcggcg actactactt caaggactgg cacgcggatc
    19561 gtcgccgtac caccagtctg ctgttgcaga aaggtgctca tgacatcgat gtgatgcact
    19621 ggctggcggg cggctacacg actcgtgcga acgccttcgg cggtttgacc ttgtacggcg
    19681 ggatcgagga ccgtctcgac aggtccggcc aacggttcgc cgacttcgtc tccgaggaca
    19741 actggccgcc gctgtcgcag accgggatgg cgccggtgat ggacgtcgag gacctgtcga
    19801 tggcgaatct cctgctggac aacggggttt acctcaccta ccagcagtgc cactacacgc
    19861 cggactactg gcgcaactac accgtcatcg gtacggcggg ccggctggag aacttcggcg
    19921 acgggccggg cggtgtagtg aaggtgtgga acagccgccg gtccgggtac cgcgaggacg
    19981 ctgaccaggt ggtcgagatc cccgatgccg aaggcggtca cggcggcgcc gacccacgac
    20041 tggtccgcga gtacattcgc ttcgtccacg agggcggcgc gacgctcacc tccccgatcg
    20101 ccgcccgcgc cgcggtcgcc gccggttacg cggccaccac atccctgcgc gacaacggca
    20161 ctccgatcga cgtcccgccc ctggacccgg cgttaatcga ctacttcgac aacggccaag
    20221 tgctaccatc gccgtcgtga tcaggtacgc cgccatgcga atgctgagcc ctcgatgcgg
    20281 aggactctag cggcgtacgc acgtgatgct tgcagctgag aggcctcctg tgtcgggggc
    20341 ctctcttcat ttgtcctcag ctgcaaacat caggagccgc tatgtatccg atcacctaca
    20401 tcaccgactg ttccgacggc aatgcccggg ccaggctgag cacccgcatc ggcgccttgt
    20461 tcggtcagac accgacaatc gtcgccgcgg acggacctga cccggaatcc ttcgccgcgt
    20521 tgaccctgct ggactgtttg agatcgacgg aatcccttgg tgagcaggga tttccgacca
    20581 tcaccctggt caacatcgcg ccgcgggacg gtcactggcc gaacggtgtg ccgttctgct
    20641 atttccacaa cgggcgacat ctcgtcgcca gcactttcaa cgcgcgggtc ttgtcgctgg
    20701 tccgccggga gcttcacatc tccgaggtct atctcaccga cgtccgcgag gtggtggaat
    20761 cggccggtct cgacaacgtc cagaagattg tggatacgca gttccgcagc ctctggtacc
    20821 tgccactgct ggcgaaatgg gtcgtcgacg accgcccggt gccctcgacg ccaaccgccg
    20881 taccgatcac gaccgctgac gagccgacgg tcagcgtcat cgacaacttc ggcaactgca
    20941 agttcgactg cggccccgac gcgatcggct tcgccgtcgg cgactcgctc ccggtcgccg
    21001 gccgcacgcc gagtggcacg atcaccttga ccgacgtcac ctgctatccc cacctgaccg
    21061 ccgtacccga gggaaccccg ggcctcatcc ccggcagctc aggcaccaac ttcatagaac
    21121 tggtcatccg cggcgtctca gccgccgccg cattcggcct ccaaccaggc gacgccccct
    21181 tgcggaggtc ttccgaggaa tacgcagctt gacccttcgg ccgaccgccg gcggcgccgc
    21241 ggctcatcag ggtgccagag gcgggatttg aacccgcacg cccgggggca ccggcaccta
    21301 aagccggcgt gtctgccgtt ccaccactct ggctgaggga gtcgcctccc cgtcggaaga
    21361 catcctaggg gaggcgacct cgttcagcgg ctttggagtg cgtcgatgaa gacttcgcgg
    21421 aggtcggtgg ggttgcgggt gacgtaggac tggccgccgg tggccgcggc gaggcggcgg
    21481 agttcatcgg cgttgacgtc cgggcccatg ccgagggcga tgatgcggac cgggcgggcc
    21541 gggtcgcgca gaccctcgag caccttgatc gcggaatcca gcgtggggcc gttcgggtcg
    21601 tcgttctggc cgtcggtgaa gagcaggatc gagttgacgg cgctggagtc gtactgctgc
    21661 cgtactgcgc ggaccgcggc gatcgcggtg tcgtacagac cggtgccgcc gttggggacc
    21721 gcgtgctgga ccctcaggtt gtcgacgatc ttcttgcgct gccggtccga cagtggcgcg
    21781 atcgggacga gttccttgta gtcggcgccg tccggcccga tcttggtcga gaacgtccac
    21841 agaccgagcg acgcgctgtt cgggaacagc gccaggccgc cggaggccgc ctcgatggtg
    21901 agctgcatcc gggtcttgtt gccgaccttc tccgccatcg agccggagat gtcgatcacc
    21961 gccagcgagt gggtggacaa cgacagccgg gtccagttca gcagcgtctt gtcgatcgcg
    22021 tcggaggtcg gcttggtcag ctgggtgatg tcgccgacgc cgcggccgcc gctgagcggg
    22081 ctgatcaggc ggtcccggaa gccggcgtcc tcgcgggcct ggctcgcgct gtcggtgatg
    22141 agctcggtgc cgagcgcctt ggccgcctcg gtgacggctt cggcgtcgga cttcgaggtg
    22201 accacgatcg ggtagtccag caccagcgtg ccggtagccg gtacgacggc cttgagctcg
    22261 gactccgggt ggtcttcctg gtacttcacg aagctctgct cggaggccgg tacgacgagc
    22321 gtgcttccct cctggttggc tctgccgaac aaggcggctg tatcggtgta cggcttcgcc
    22381 atcgagccga gccgctgcgc gagcggcacg atcacgcccg ccacctgggt gtcggacgcc
    22441 gacgtcttcg tccgctcggc ctgtacggcg agcagtgcga gtgcgccggg cgacgtactg
    22501 agtgggtcca gcagggccgg ctcggcaccg gcgaaggaac gcagccagga cgaggtgtcg
    22561 gcgaagttgg agttccggcc gaccaggacc agtggagagg tcgcgacgga cggtacggcg
    22621 atggtcggga cggtctgccc gtcgtcgg
//
