LOCUS       NZ_SLWR01000003        22568 bp    DNA     linear   CON 05-APR-2024
DEFINITION  Kribbella antiqua strain VKM Ac-2541 Ga0310564_103, whole genome
            shotgun sequence.
ACCESSION   NZ_SLWR01000003
VERSION     NZ_SLWR01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kribbella antiqua
  ORGANISM  Kribbella antiqua
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 594475)
  AUTHORS   Whitman,W.B., Woyke,T., Klenk,H.P., Zhou,Y., Lilburn,T.G.,
            Beck,B.J., De Vos,P., Vandamme,P., Eisen,J.A., Garrity,G.,
            Hugenholtz,P. and Kyrpides,N.C.
  TITLE     Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase
            III: the genomes of soil and plant-associated and newly described
            type strains
  JOURNAL   Stand Genomic Sci 10, 26 (2015)
   PUBMED   26203337
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 594475)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 185.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004345665.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 04:15:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,825
            CDSs (total)                      :: 7,760
            Genes (coding)                    :: 7,713
            CDSs (with protein)               :: 7,713
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 7 of 47
            Pseudo Genes (incomplete)         :: 41 of 47
            Pseudo Genes (internal stop)      :: 3 of 47
            Pseudo Genes (multiple problems)  :: 4 of 47
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:43:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 103790
            Orig. end                         :: 126358
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SLWR01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22568
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22568
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22568
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12568](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12568)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(222..235)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.74"
                     /tool="antismash"
     misc_feature    223..236
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.64"
                     /tool="antismash"
     gene            289..810
                     /locus_tag="EV646_RS09900"
                     /old_locus_tag="EV646_10399"
     CDS             289..810
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391570.1"
                     /locus_tag="EV646_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10399"
                     /product="2TM domain-containing protein"
                     /protein_id="WP_132146461.1"
                     /transl_table=11
                     /translation="MLLAVIAACEIGFWVLLAAGMVMRYVLRLRRVGMVLLASLPLVDV
                     VLLVASVIDIRRGAEPSFKHSLAAIFVGVSVAFGHQTLKWADNWAAHWFAGAPRPVKPP
                     KSASRERAGWYRHLLAYVIGVGLMLVLGLLSGHGYDALLGPAGTWTLVLGIDAIVSFTA
                     KSDDQEKAPA"
     gene            921..1562
                     /locus_tag="EV646_RS09905"
                     /old_locus_tag="EV646_103100"
     CDS             921..1562
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391571.1"
                     /locus_tag="EV646_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103100"
                     /product="Pr6Pr family membrane protein"
                     /protein_id="WP_132146464.1"
                     /transl_table=11
                     /translation="MTMTGRSWAGATALLVAVGVVVQLFVTANGNEGFFKDNPERVLNV
                     FAFFTIQSNLLLGATTLLLALQPERRQSTLFRTLRLNGVLCIAVTGIVYHLVLAPLDDL
                     SGWAAVANFLLHTATPVAGVLGWLLFGPRGQTNPRIVAWSIVFPLLWLVFTLIRGAFVG
                     FYPYPFVDVTEHGYPRVLLNCLLVAVLFLALAAGATFLDNRLYRKTIVEG"
     gene            1567..2217
                     /locus_tag="EV646_RS09910"
                     /old_locus_tag="EV646_103101"
     CDS             1567..2217
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391572.1"
                     /locus_tag="EV646_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103101"
                     /product="hypothetical protein"
                     /protein_id="WP_132146467.1"
                     /transl_table=11
                     /translation="MLVTSRSYVEYEAMFDLTQLPESVLDCSAGGSSFTAEAAERGVDA
                     VAVDPAYELGQSELVDTVRRSLPAGSGIVDQNQGSFVWHWYGTPERRDELRVEAADRFL
                     QDIAAAPERYVAGALPELPFEDRRFELVLCSHLLFTWADQFDEAWHVAALRELIRVSSA
                     EVRIFPLVVQGTGEPVSFLPSVLDSLEGVTWEVRKVPYEFQAGANEMLVLTRS"
     gene            complement(2391..3008)
                     /locus_tag="EV646_RS09915"
                     /old_locus_tag="EV646_103102"
     CDS             complement(2391..3008)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391573.1"
                     /locus_tag="EV646_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103102"
                     /product="transglycosylase family protein"
                     /protein_id="WP_132146470.1"
                     /transl_table=11
                     /translation="MSKARHARPRRSTRRVVRTLSIAGLGAGITAAGAGAAFATDYTVK
                     AGDTLSEIAQANGADWHHLAKINNLDNPDLILIGQTLTLDGVEKATAPRPRTTSKKVET
                     KKVRKTERKVRTSRSEDRPATSVSMSAAWRKVAQCESSGNPRAVNPAGYYGLFQFDLQT
                     WRSVGGSGNPAKASAAEQLMRAKKLYAQRGASPWPVCGRYLR"
     misc_feature    3108..3123
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     gene            complement(3398..3934)
                     /locus_tag="EV646_RS09920"
                     /old_locus_tag="EV646_103103"
     CDS             complement(3398..3934)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039927.3"
                     /locus_tag="EV646_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103103"
                     /product="DUF5946 family protein"
                     /protein_id="WP_132146473.1"
                     /transl_table=11
                     /translation="MNSPDDTHESRRCPGCHADLPRSDWPGETKYNASPECLEVAGQLL
                     GYEIEHAVELGYLHQLRIDAYGAQHVSPQQPPIGPVFALNGLYMYLERGSGNLDVRTAH
                     SIMANSYDDWPVLTPPSTVGRLTAYDVLNAGSVQDVEAALITWADQVWQSWPAADQELI
                     RKLTIALVPPRHFRR"
     gene            3999..4631
                     /locus_tag="EV646_RS09925"
                     /old_locus_tag="EV646_103104"
     CDS             3999..4631
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012920101.1"
                     /locus_tag="EV646_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103104"
                     /product="response regulator transcription factor"
                     /protein_id="WP_132146476.1"
                     /transl_table=11
                     /translation="MRRRKATGGEDVIRVALGHRGTLVRGALAAVLARENDLDVVAELD
                     RSEDVLQVAGRRPHVVLLDAQLPGRIRIEELCRKLTGRGVLVMIDHEAIAATSLSLVKQ
                     APRIGLIATDSTTDQLVQAIRDVAKGLPVVDVRLAVAALKAGDNPLTDRECEVLRHVTT
                     GATAQEIARTLSLSTGTVRNYLSRALAKTGARSRIEAIRKAQDAGWI"
     gene            complement(4610..6280)
                     /locus_tag="EV646_RS09930"
                     /old_locus_tag="EV646_103105"
     CDS             complement(4610..6280)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391575.1"
                     /locus_tag="EV646_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103105"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132146479.1"
                     /transl_table=11
                     /translation="MKRELAYGAQALKKRASIKLVAWSVPEILPTAVYGIAVAHATDNF
                     LAGHAWQGIAWLGGLVATACLGAAGARQVYGRLGELVEPVRDDLVRRVVAGALRTGDDS
                     AVARLNRQVEIVRDTFAGLVLVIRSFAVTLFGVLAGLLSLAPLVAAFVVPPFIVGFALS
                     LAVLGMAADRVRASLQADEELAASAGMVFGGVRDITASGTEEFASRLVGEPIEAHASAE
                     RALAKVAALRTLCFAVGGWLPLLILLATGPWLVGRGVSTGTLLGGLTYVLIGLQPALNT
                     VMSALGDSGLRYVITLGRILDTSAPVDRPRRSVAQGYQVRMQGLTFSYGPHAEPVLDNL
                     ELMIPEGEHLAIVGPSGIGKSTLAGLICGMLSPTRGRLLLGGANPAEVPTETRVLIPQE
                     AYVFSGTVLDNLTYLLPEATDPTDAIEAVGAGALIAQIGGLAAMVKPGELSAGERQLIA
                     LVRAYISPAPLVVLDEATCFLDPEAERRAEEAFARRGGTLIVIAHRVSSARRAKRILVL
                     DGNKAALGAHATLMRTSRLYRELQGHWTPEVRRQIQPAS"
     misc_feature    complement(5141..5143)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6277..7929)
                     /locus_tag="EV646_RS09935"
                     /old_locus_tag="EV646_103106"
     CDS             complement(6277..7929)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012920099.1"
                     /locus_tag="EV646_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103106"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132146482.1"
                     /transl_table=11
                     /translation="MITFKTVVKRGRAWLPLIGLNSLIASGVTLALPTILGRSVDSIVA
                     DDGYTKWLIAAAALIALGVMANLVDAFAGAACVADTTAWLRHRLVKQVVHSGPEGTRDF
                     ETGDLVTRVSANATDAAQAGPAAVTAIAAIAPPIGSLVLLAFIDPWLAAAFFGGVLLVI
                     AVLWTFARRTADVSLAYQETQGRIASLLSESLTGIRTIAAAGTTTREERRILGLLPELH
                     KHGMVTWRILARSGAQAAIVGPLVLVAVLAVGGLQLVDHRITAGEWFAASQYAVIGAGL
                     GSLTGVIGGLARAKAGVHRAAEVLKVPTVAHGTLSLPTGPGRLTFDSVSVETNGNVLLD
                     NVNLDLPGGATVAVVGPSGAGKSVLAAVAARLRDPSTGQVTLDGVPLQAINRHALRSAV
                     GCAFERPQLVGRTIGDAIEPDAVSPIRTLAAARATHAHDFVSRLPDGYFTSLRKAPMSG
                     GERQRLGLARAWSANRLLVLDDATSSLDTATEMQISRTLTEDRHRRTRLIVTHRPATAA
                     RADLVIWLDRGRVRAVAPHADLWRNDSYREIFG"
     gene            complement(7926..9767)
                     /locus_tag="EV646_RS09940"
                     /old_locus_tag="EV646_103107"
     CDS             complement(7926..9767)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076002.1"
                     /locus_tag="EV646_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103107"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_132146485.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.5e-41, bitscore:
                     137.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAHRLPLVEKVHGHLVADPYRWLEDSASPETQRWQAIQDDLWLN
                     HATTLTTRYHFRAHVKALSNVGTVSAPIWRGDRCFTLRRDPGQQHPVLYVGPKSLIDPM
                     QLDPTGLTTLDSWQPSPDGSLVAYQISRGGTEQSVLYVLDVTTGQVTDGPIDGCRYSPV
                     AWLPDGNAFYYVRFRQVRRHRLNDAGDTTILEGEASYGLEISADGRWLTISAARGTTND
                     LWLADLSTNEPPKPVEQDALTVMTVAPDGRLYVVTTKDAPTGRLCIGDPTSPSVWHDFV
                     TPTKPLTGFAILDDAILLATTSEIAIHDRETGRRTGDVPLPGLGSIGTITTHGSQAWFT
                     YTDSVTPSAVYCYDDTTGRTTLWSEAPGPKAEAETHQLTCNPELHLTAIAKPGTGPRPT
                     ILYGYGGFGQDLTPTYSAFALAWVEAGGVFVTAHLPRRDRKQQVIDDFIGAAEHLTAEG
                     WTTPAQLALCGESNGGLLVAAALTQRPELFAAAVCSAPLTDMTRYELSGLGPRWTEEFG
                     SAKNADDFDHLLSYSPYHRVTEGVKYPAVLFTVFGNDTRVDPLHARKMCAALQHATGRE
                     RPVLIRLDPDAGHAAGSASQGIGLAADMLAFLAEQTT"
     gene            complement(9860..9997)
                     /locus_tag="EV646_RS09945"
                     /old_locus_tag="EV646_103108"
     CDS             complement(9860..9997)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391578.1"
                     /locus_tag="EV646_RS09945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103108"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_132146488.1"
                     /transl_table=11
                     /translation="MALLDLQGLETPGYGGGHHHPGGSTLTVLGCASQTPSNLSLLLCH
                     "
     CDS_motif       complement(9944..9997)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGLETPGYGGGH"
                     /locus_tag="EV646_RS09945_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9860..9943)
                     /prepeptide="core"
                     /locus_tag="EV646_RS09945_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="5.70"
                     /molecular_weight="2618.0"
                     /monoisotopic_mass="2616.4"
                     /core_sequence="HHPGGSTLTVLGCASQTPSNLSLLLCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGLETPGYGGGH"
                     /leader_location="[9943:9997](-)"
                     /alternative_weights="2636.0"
                     /alternative_weights="2654.0"
                     /alternative_weights="2672.0"
                     /alternative_weights="2690.1"
                     /alternative_weights="2708.1"
     gene            complement(10001..12568)
                     /gene="lanKC"
                     /locus_tag="EV646_RS09950"
                     /old_locus_tag="EV646_103109"
     CDS             complement(10001..12568)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924048.1"
                     /locus_tag="EV646_RS09950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103109"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_132146491.1"
                     /sec_met_domain="micKC (E-value: 4.7e-240, bitscore: 794.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2e-18, bitscore: 61.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.3e-07, bitscore: 27.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-07, bitscore:
                     25.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHETAQESYEFYCLADRRFYETPANRGAEHPDFALCSRPVPDGWR
                     HVPGETWMHYAPAELRLPQQGWKIHVSARLADVERTLEAVWEYCVPRGIAFKFLRNEPV
                     LVMVNSKAAPRGSSGKLVTIYPADEAQLELILKELDGILHGVEGPYILSDLRYAEGPLF
                     VRYGAFVSRYCLSPTGERVLALEDDNGTLVPDHRGPTFSTPPWVTLPAFLEPHLEARNA
                     VTTNDLAYTIDGVIQFSNGGGVYLGRHNETGDRVVLKEGRPYAGLDMSGRDAVARISHE
                     RDILEQLDGLSVVPKVHDYLQLGEHHFLVQEHIDSVSLQRELVRRYPLTHPDASEADKA
                     EYAEWATRIVEQLAQAVGQLHERGVVFCDLHPDNVLLDADGNLTLIDFEVATRAEDRAR
                     STLAHPGYAAPPDRQGVEVDRYALACIALGVFAPQTTILLNLHPGKAFHLAEMITETFP
                     VPRATIDQAVSIITDAGNELADLALPGKAGWTEVRDALTRSIVASATPERADRLFPGDI
                     AQFRPGAGIDIATGAAGVLYALKRTGAERFPQYDDWLRKRALDTETGPGLYDGLHGVAH
                     VLDELGYRQDALDLVDRTLVDDWTSRELGLHSGLAGIGLNLLHFDTEPTLRAKAVRVLD
                     LVADRLGDVTDVPEISGGQHARAGLMYGSSGPALLFLNAFEQLGDTGLLDLAEIAIRQD
                     LRRTLITPDGTRQINQGWRTLPYLEEGSAGIALVVERYLRHRPSDELAGSLEELTKVTH
                     CDFYVQPGLFMGRAGLLLTASALGEQVDDLVYGLGWHALPFAGGLAYPGNQLLRLSMDL
                     ATGSAGVLLALGTALHEAPVSLPFLGPPQWSESSSRQPALKEV"
     misc_feature    complement(12564..12577)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     misc_feature    complement(12724..12741)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            12831..13901
                     /locus_tag="EV646_RS09955"
                     /old_locus_tag="EV646_103110"
     CDS             12831..13901
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV646_RS09955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV646_103110"
                     /product="transcriptional regulator"
                     /protein_id="WP_132146494.1"
                     /transl_table=11
                     /translation="MTGPDVDDSRRTWLDVRRYLVDNRYRLGVEAADEFAVDRRVAGTP
                     LLAPASWIPSTPIPLASVELQFEPDAEFSGVTGARAALPYGSYAEAIAELAPPAVFENR
                     PTYRLLDADLAGATPVLRLGRGTYFDSINTGEAAAHEYAARQLSPDAPGGLRAAIGDPW
                     DATRRPINLAISTLTIRRDSTSTFFLHWRDPAKVGHAGGLYQVVPSGIFQPSADAPWNE
                     AHDFSLWHNVVRELAEELLGASEDHGSGAAPIDYHDWPFAARLSTGLEDGSVRAYCVGL
                     GVDPLTFATDLLTVLSISADLFDELFGQVNADNDEGQVLAPQPFTAEAIDEFVNRKPMQ
                     AAGAALLQLASNHQLG"
     gene            13945..14616
                     /locus_tag="EV646_RS09960"
                     /old_locus_tag="EV646_103111"
     CDS             13945..14616
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012918912.1"
                     /locus_tag="EV646_RS09960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103111"
                     /product="Type 1 glutamine amidotransferase-like
                     domain-containing protein"
                     /protein_id="WP_132146497.1"
                     /transl_table=11
                     /translation="MKFLLTSSGVRNPSIHSALADLLDKPISECTALCIPTAAYYFPEG
                     PAIAYRLISGTSQGRLVDLGWKSVGVLELTALPSVAEENWIPLVKETDVLLVGGGDPMY
                     LCHWMRESGFADLLPSLRSETVYVGVSAGSMAVTASFGENYNDRPVPTTGTETPLGLID
                     IAIYPHLNHPAMEDTQEANIATWATKVPVPTYALDDNSAIKVTNGTIDVTTEGHWKLFQ
                     P"
     gene            complement(14613..15674)
                     /locus_tag="EV646_RS09965"
                     /old_locus_tag="EV646_103112"
     CDS             complement(14613..15674)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391581.1"
                     /locus_tag="EV646_RS09965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103112"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132146500.1"
                     /transl_table=11
                     /translation="MTLYADVRVSRGAFDLSLDLTVEPGEVVALLGPNGAGKTTALRAI
                     AGLLPVGAGRVALDDEVWDEPPRVFRTPDRRPIGVVFQDYLLFDHLSALENVAFGLRAR
                     GVEKHAARAEALRWLGAVGLASYARSRPRALSGGQAQRVALVRALATSPSVLLLDEPLA
                     ALDASTTLHVRAELGQHLNRYEGRTLLVTHDPLDAMVLADRLVIVENGRIVQQGRPTDI
                     ARRPRTDYVAQLVGLNLYRGTATNTTVALTDGGTITLAEPASGPVHVAFPPTAVSLYPE
                     PPTGSPRNTWPAVVTGIEQHAHTVRVRLDATPTGPTTLLADITPAAVADLHLTPGQHLH
                     ATLKATEIHTYPS"
     gene            complement(15671..16435)
                     /gene="modB"
                     /locus_tag="EV646_RS09970"
                     /old_locus_tag="EV646_103113"
     CDS             complement(15671..16435)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015412 - ABC-type molybdate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015689 - molybdate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="modB"
                     /gene_functions="transport (smcogs) SMCOG1214:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924045.1"
                     /locus_tag="EV646_RS09970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103113"
                     /product="molybdate ABC transporter permease subunit"
                     /protein_id="WP_199236914.1"
                     /transl_table=11
                     /translation="MLLLPALVGLAFLLVPLIGLLIKAPWSTLPSRLFSADIWQALRLS
                     LLCATLATTVCLLLGIPLAWLLARASLPGRGLIRALVTVPLVLPPVVGGVALLLVLGRR
                     GLIGERLDLWFGFSLPFTTAGVVVAEAFVAMPFLVISVEGALRAADPRYEEAAATLGAG
                     RWLTFRRVTLPSIAPGVVAGAVLCWARALGEFGATITFAGNLPGRTTTMPLAVYLALET
                     DPDVAVVLSLVLLLVSVVVLASLRERWISGLR"
     gene            complement(16498..17274)
                     /gene="modA"
                     /locus_tag="EV646_RS09975"
                     /old_locus_tag="EV646_103114"
     CDS             complement(16498..17274)
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015412 - ABC-type molybdate transporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0030973 - molybdate ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015689 - molybdate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="modA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391583.1"
                     /locus_tag="EV646_RS09975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103114"
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_132146510.1"
                     /transl_table=11
                     /translation="MFRRTALAALAAAAALTLAGCGNDSPAASSSGSSTTALSGTVNVF
                     AAASLTGSFTQLGKDFEKAHPGVKVNFNFAGSSALAQQINQGAPADVFASAAPKNMDQV
                     ADKNTPTTFVKNTLEIAVPTGNPGKITGLKDFADKNKKIALCAVQVPCGAAADKVFKAV
                     GITPQPDSLEQDVKAALTKVSLGEVDAALVYKTDVLSAKGKVEGIEFPEASTAVNEYPI
                     ATLTKAPNADGAKAFVDYVLSDQGKAVLTASGFDSP"
     gene            complement(17274..17669)
                     /locus_tag="EV646_RS09980"
                     /old_locus_tag="EV646_103115"
     CDS             complement(17274..17669)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924043.1"
                     /locus_tag="EV646_RS09980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103115"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_132146516.1"
                     /transl_table=11
                     /translation="MPNLRISEAAALLGVSDDTVRRWVEQGRLPSVQDGGRMAIEGREL
                     ATFAQELAESPEPGATAAASARNRMRGIVTRVVKDVVMAQVELQAGPFRVVSLMSREAA
                     DELGLEPGVVAVASIKSTHVVVEIPEA"
     gene            17770..19695
                     /locus_tag="EV646_RS09985"
                     /old_locus_tag="EV646_103116"
     CDS             17770..19695
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_function="GO:0003997 - acyl-CoA oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391585.1"
                     /locus_tag="EV646_RS09985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103116"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_132146519.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.3e-08, bitscore:
                     29.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.6e-18, bitscore:
                     60.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.9e-14, bitscore:
                     48.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METSGLREYLDGPYKAARDVVRAGLEANPELLDFAVTLPTDEYRD
                     KVLELLQQITAEGHPARGFPKEYGGEGDLGGFIAGFETLAFGDLSLMVKAGVQFGLFAG
                     AILHLGTERHHERYLADAVSGRLLGCFAMTETGHGSNVQALGTTATYDASTGEFVVHTP
                     TPSARKDYIGNAARHGRMAAVFAQLVVGGETHGVHCLLVPIRADDGTAMPGVTLTDCGP
                     KLGLNGVDNGRIVFDQVRVPREALLDRYAQIDAEGNYKSEIENPDRRFFTMLGTLVQGR
                     VSVGGAAINASKVALAIAIRYGDQRRQFGAPGSAEEALLLDYRMHQRRLLPLLARTYAL
                     HFAQAELVDEFVRIFGDGSSEHDRRALEAQAAGTKALGTWHATETIQTCREACGGAGYL
                     AENRLATLKADTDVFTTFEGDNTVLLQLVAKGLLTDYRESFGKLDPLGTARFIAAQAVE
                     IAVEKAALRPLVERLRDVVPNRSGDSADPDAGLRDDGYHSGMLRFREEHMLAGVARRLK
                     AGIDAGDEPFEVFNRCQDHVIAAGRAHVDRVVLEAFQAAVADAPEEIRQLLKDVCDLHA
                     LATIEAERAWYLEHGRLSPGRSKAITALVNELCAVVRPAAVELVDAFGIPGSAVEVPMV
                     VPSQHE"
     gene            19688..20314
                     /locus_tag="EV646_RS09990"
                     /old_locus_tag="EV646_103117"
     CDS             19688..20314
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391586.1"
                     /locus_tag="EV646_RS09990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103117"
                     /product="hypothetical protein"
                     /protein_id="WP_132146522.1"
                     /transl_table=11
                     /translation="MSEPIEPASAAEAARELARVLLEQADALDLHDLRATGAIENVRVQ
                     ARALADAVHERGWGDIFLGIDSYDPDELDDLPLGPDDFDDPEDYREIVEGDSLGDLDDL
                     EEPLLPEDGVRLSYQARYDFVVTDPEAFVQYVRSRADEAQNDEVIDDIEDVQSAFELLC
                     YLDGLGSKDYDTAGLTPAGGEEAHKIVEFSLWDLDPTRRDDTYPY"
     gene            complement(21119..21757)
                     /locus_tag="EV646_RS09995"
                     /old_locus_tag="EV646_103118"
     CDS             complement(21119..21757)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020578166.1"
                     /locus_tag="EV646_RS09995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_103118"
                     /product="response regulator transcription factor"
                     /protein_id="WP_132146525.1"
                     /transl_table=11
                     /translation="MRIVIGEDSALFREGLSRLLTENGHTIAGTASDADELVSVVRAVD
                     PELTIIDVRMPPTMTDDGARAAAVLRNEVPERPILMLSQHVETRHVVDLVGTGAFGYLL
                     KDRVLRVADFLDAMRRVADGGSALDPAIVAALVTPTRANDPLAALSAREREVLALVAEG
                     RSNSAIAAQLVLAERTVETHMRSIFQKLRITDTPDTHRRVLAVLTHLTG"
ORIGIN
        1 gaagctcagc aagccggctt gatcggggaa gtagtagcgg acggccccgg ctgaccagcc
       61 ggcttccgcc gcgatggtcc ggaccgaggc ggcgcggatc ccgtcccggc ggacgacccg
      121 ccagagcgct tcggcgatct cctcgcggcg ggtgtcgtgg tcgacgatct tcggcacagg
      181 acctttttag cacagccgtg ctaagatctt tgctaacaca gttgtactta ataaaagcat
      241 cccttgctcc gctcggggcg ggggagtcca aggggagggt gaaccgctgt gctgctcgct
      301 gtgatcgccg cgtgtgagat cggcttctgg gtcctgctcg ccgccgggat ggtgatgcgc
      361 tacgtgcttc ggctgcggcg cgtcggcatg gttctgctcg cgagccttcc gctggtcgac
      421 gtcgtgctgc tggtcgccag cgtgatcgac atccgccgcg gtgccgagcc gtcgttcaag
      481 cactcactgg ccgcgatctt cgtcggtgtc agcgtcgcgt tcggtcacca gaccctgaag
      541 tgggcggaca actgggccgc gcattggttc gccggcgcac ctcgcccggt caagccgccg
      601 aagagcgcca gtcgcgaacg cgccggctgg taccgccacc tgctggccta cgtcatcggc
      661 gttggtctga tgctcgtcct cggcctgctc tccggtcatg ggtacgacgc tctgctcggc
      721 ccggccggca cgtggaccct cgtcctcggc atcgacgcca tcgtctcctt caccgccaag
      781 tccgacgacc aggagaaggc cccggcctga cccactttgt gcacgggatc cgtactttct
      841 ggccggcgcc gtacggatcc cgtgcacaaa gtcgtcggga gttccccggc gcggcggtgt
      901 gtgcgtcgta cattgcgggc atgacgatga cggggcggtc gtgggctgga gctaccgcgt
      961 tgctggtggc tgtcggcgtc gtggtgcagt tgttcgtcac ggcgaacggg aacgaagggt
     1021 tcttcaagga caacccggag cgggtgctga acgtgttcgc gttcttcacg attcagtcga
     1081 atctgctgct cggcgcgacg acgttgctgc tggcgttgca gccggagcgc cggcagagca
     1141 cgttgttccg gaccttgcgg ctgaacggcg tgctctgtat cgcggtgacc gggatcgtct
     1201 atcacctggt gctcgcgccg ctggacgatc tgtccggctg ggcggcggtg gcgaacttcc
     1261 tgctgcacac ggccacgccg gtggccggcg tactgggctg gttgttgttc gggccgcggg
     1321 gccagacgaa tccgcggatc gtcgcgtggt cgatcgtgtt cccgctgttg tggctggtgt
     1381 tcacgctgat ccgcggcgcg ttcgtcggct tctatccgta tccgttcgtc gacgtcaccg
     1441 agcacggcta tccgagggtg ttgctgaatt gtctgctcgt cgcggtactg ttcctggctc
     1501 tggcggccgg ggctaccttc ctcgacaacc gcctgtaccg gaagacaatc gtcgaagggt
     1561 aagaccgtgc tggtgacctc tcgctcgtac gtcgagtacg aagcgatgtt cgacctgacc
     1621 caactccccg aatccgtgct cgactgctcc gcgggcggtt cgagcttcac tgccgaagcc
     1681 gccgagcgtg gcgtcgacgc ggtcgccgtc gacccggcgt acgagctggg tcagtccgag
     1741 ctcgtcgaca ccgtacggcg gagtctgccg gccgggagcg ggatcgtcga ccagaatcag
     1801 gggagcttcg tctggcactg gtacgggaca ccggagcgcc gggacgagct gcgggtggag
     1861 gcggcggacc ggttcctgca ggacatcgcc gcggcgccgg agcggtacgt cgcgggcgcg
     1921 ctcccggagc tgccgttcga ggacaggcga ttcgagctgg tgctgtgctc gcacctgctg
     1981 ttcacctggg ccgatcagtt cgacgaggcc tggcatgtcg cggcgctgcg tgagctgatc
     2041 cgggtcagca gcgcggaagt ccgcatcttc ccgctggtgg tgcaaggaac cggcgagccg
     2101 gtctccttcc tgccgtccgt gctcgactcc ctggaaggcg tcacctggga ggtccgcaag
     2161 gtgccgtacg agttccaggc gggcgccaac gagatgctgg tgctcacccg cagctgacgt
     2221 ctggtgcctc ccacccgtcg cgatcacgga tgagtagcgc actaacccgc cacgaggggt
     2281 gggaggcgcc aaacgtcagc taatcggggg ctgcagtgat gaggagctgc agcgatgagg
     2341 ggccggccgg gtggacggtc tgccgcccgc ccgaccggtt ggagagggtg tcagcggagg
     2401 tagcggccgc agaccggcca gggcgaagcg ccgcgctggg cgtacagctt cttcgcgcgc
     2461 atcagctgct cggccgccga cgccttcgcc ggattgccgc tgccgccgac gctgcgccac
     2521 gtctgcaggt cgaactggaa caggccgtag tacccggccg ggttgaccgc gcgtgggttc
     2581 ccgctggact cgcactgggc gaccttccgc caggcggcgc tcatgctcac gctcgtcgcg
     2641 ggacggtcct cggaccggct ggtccgcacc ttgcgctcgg tcttccgcac cttcttcgtc
     2701 tcgaccttct tcgaggtcgt ccgcgggcgc ggagcggtgg ccttctccac accgtcgagc
     2761 gtcagggtct gcccgatcag gatcagatcg gggttgtcca ggttgttgat cttcgccagg
     2821 tgatgccagt cggcaccgtt ggcctgggcg atttcggaga gggtgtcgcc ggccttgacc
     2881 gtgtagtcgg tcgcgaacgc cgcaccggcg ccggcggcgg tgataccggc cccgaggccg
     2941 gcaatggaga gggtccgaac cacccggcgg gtacttcgcc gggggcgcgc atgtcgggct
     3001 ttggacatca gtagtgcaac tccttgtgag cttgggcatg gtgaaactca ccaggccccc
     3061 cgtgcaggga ggggcatccg ggcaggtcac aggacagctt ccgaatggtc acgccacggt
     3121 aacgacgtga cctgagtcat cctgggcgac cctggcggga agcgcaaggc caatccgcga
     3181 atctgccccg gtttttttcg gctccttgac gtagcgaaag cccaacaaca gaacggtttc
     3241 ccgccgtgac acgcgtttca aacgccttcg ttcacacccg cgccccccgg agtagccgag
     3301 ccaccgtccc cgcctcggcc gaccttgaga agccaccggc cgtttcggga gcggttttgt
     3361 ggttggtggg ctctcaaggt ggggaaaccg atgggtttca gcggcggaag tggcggggtg
     3421 ggacgagggc gatggtgagt ttgcggatca gctcctggtc ggccgcgggc cacgactgcc
     3481 agacctgatc ggcccaggtg atgagcgcgg cttcgacgtc ctgcaccgag cccgcgttca
     3541 gtacgtcgta cgccgtcaac cggccgacgg tcgacggtgg cgtcagcacc ggccagtcgt
     3601 cgtacgagtt ggccatgatg ctgtgggcgg tgcggacgtc gaggttgccg gagccgcgct
     3661 cgaggtacat gtagaggccg ttcagtgcga acaccggacc gatcggtggc tgctgcgggc
     3721 tgacgtgctg ggcgccgtac gcgtcgatgc ggagctggtg cagatagccg agctcgacgg
     3781 cgtgctcgat ctcgtagccg agcagctgtc ccgcgacctc gaggcactcc ggtgacgcgt
     3841 tgtatttcgt ctcgcccggc cagtccgagc ggggcaggtc ggcgtggcaa ccggggcagc
     3901 ggcgggattc gtgcgtgtca tccggggagt tcactcgttg atcgaagcac gggcaccgcc
     3961 gtccggcagc tggttttcgt cgcgggcggg ggcccgggat gaggcgacgg aaggcgactg
     4021 ggggcgaaga cgtgatccga gtggctctcg gccaccgcgg cacgttggtg cgtggtgcac
     4081 tggcagcggt gctggcaaga gagaacgatc ttgacgtggt ggccgagctg gaccgctcgg
     4141 aggacgtcct gcaggtggca gggcggcggc cgcacgtcgt actgctggat gcccagctac
     4201 cgggccggat ccggatcgag gagttgtgcc ggaagctcac cggccgtggc gtgctggtga
     4261 tgatcgacca tgaggcgatc gcggcgacga gtctgtcgct ggtcaagcag gcgccgcgga
     4321 tcgggctgat cgcgacggat tcgacgacgg accagctggt gcaggcgatc cgcgacgtgg
     4381 cgaagggctt gccggtggtc gacgtacggc ttgctgtggc tgcgttgaag gcgggcgaca
     4441 atccgctgac ggatcgcgag tgcgaggtac ttcgtcatgt cactacgggg gcgacagcgc
     4501 aggagatcgc gcgcacgttg agtttgagca ctgggacggt ccgcaactat ctctcccgcg
     4561 cgctcgccaa gacaggagcg cgcagccgga tcgaggcgat tcgaaaggct caagacgccg
     4621 gctggatctg acggcgtacc tctggtgtcc agtggccttg gagttctcga tacaggcggg
     4681 aggtgcgcat caaggttgcg tgcgcgccga gggccgcttt gttgccgtcg aggacgagga
     4741 tgcgtttggc ccggcgcgcc gagctgacgc ggtgggcgat gacgatgagc gtcccgcccc
     4801 ggcgggcgaa cgcctcttcg gctcgacgtt cggcctccgg atccaggaaa caggtcgctt
     4861 cgtcgagtac gacgagcggc gctggcgaga tgtacgcgcg tacgagcgcg atcagctggc
     4921 gttcgccggc cgacaactca cccggcttga ccatcgccgc cagcccaccg atctgcgcga
     4981 tcagcgcacc ggcgccgaca gcctcgatcg cgtcggtggg atcggtcgct tcgggcaaca
     5041 aataggtgag gttgtcgagc actgtcccgc tgaaaacata cgcctcctga ggaatcagaa
     5101 cccgcgtctc cgtcggcacc tcagccggat ttgccccacc taataggagc cggccccggg
     5161 tggggctgag catgccgcag atcagcccgg cgagtgtcga cttcccgatc ccactcggcc
     5221 cgacgatcgc cagatgttcg ccttcgggga tcatcagttc gaggttgtcc aggactggtt
     5281 cggcgtgagg cccgtacgaa aaggtcagcc cctgcatgcg gacctggtac ccctgtgcga
     5341 cgctccgtcg cggccggtcg accggagctg aggtgtcgag gattcgcccg agcgtgatca
     5401 cataccgcag accgctgtcg cccagggcgc tcatcactgt gttgagcgcc ggttgcagac
     5461 cgatcagcac gtacgtgagc ccgccgagca gcgtgcctgt gctcacgccg cgcccgacca
     5521 gccacggtcc ggtcgcgagc aggatcagca acggcaacca tcctccgacg gcgaaacaca
     5581 acgtcctcag cgcggctacc ttggccaagg cgcgctccgc cgacgcatgc gcctcgatcg
     5641 gctcaccgac cagccgggag gcgaactcct cggttccgct cgcggtgatg tcccgcacgc
     5701 caccgaacac catcccggcc gacgccgcga gctcctcatc cgcctgcaac gacgcccgga
     5761 cccgatccgc cgccatcccc aacaccgcca gggacaacgc gaacccgacg atgaacggcg
     5821 gtacgacgaa cgccgcgacc aacggcgcaa gcgacaacag accagccagt acgccgaaca
     5881 acgtcacggc gaaactgcgg atcaccagga ccaggccggc gaaggtgtcg cgcacgatct
     5941 ccacctgccg gttcagccgg gcgacggcgc tgtcgtcacc ggtgcgcagg gctccggcga
     6001 ccacgcgtcg tacgagatca tctcgaactg gctcgacgag ctcgccgagg cggccgtaga
     6061 cctggcgggc gccggcggcg ccgaggcagg cggtggccac gagaccgccg agccaggcga
     6121 tgccttgcca ggcgtgtccg gcgaggaagt tgtcggtcgc gtgggcgacc gcgatgccgt
     6181 agaccgcggt cggcaggatc tccgggaccg accacgcgac cagcttgatc gacgcacgct
     6241 tcttcagcgc ctgggcgccg tacgcgagtt ctcgcttcat ccgaagatct cgcggtagga
     6301 gtcgttgcgc cagaggtcgg catgtggggc gacggcgcgg actcggccgc ggtcgagcca
     6361 gatgacgaga tcggcgcggg cggcggtggc agggcggtgg gtgacgatca ggcgggtccg
     6421 gcggtgccgg tcctcggtga gagtgcggct gatctgcatc tcggtcgcgg tgtcgaggct
     6481 cgaggtcgcg tcgtccagca ccagcaggcg gttcgccgac caggcccggg cgaggccgag
     6541 tcgttgccgt tcaccaccgg acattggtgc cttgcgcaag gaagtgaagt acccgtcggg
     6601 caggcggctg acgaagtcgt gcgcgtgggt cgcgcgcgcc gccgcgaggg tgcggatcgg
     6661 gctgacggcg tccggctcga tcgcgtcgcc gatggtccgg ccgaccagct gcggacgttc
     6721 gaacgcgcac ccgaccgcgc tccggagcgc atgacgattg atcgcctgca gcggtacgcc
     6781 gtccagcgtc acctgcccgg tcgacgggtc acgcaacctc gctgcgacgg cggcgagcac
     6841 cgacttcccg gcaccactcg gaccgaccac cgcgacggtc gcaccgccgg gtaggtcgag
     6901 attcacgttg tccagcagga cattcccgtt ggtctcgaca ctgacgctat cgaaggtcag
     6961 gcgccctgga ccggtcggaa gactcagcgt cccgtgcgcg actgtcggga ccttcagcac
     7021 ctcggccgcc cgatgcacac cggccttggc gcgggcgagc ccgccgatga caccggtcag
     7081 actgcccagg ccggcgccga tgacggcgta ctgggaagca gcgaaccact cgcccgcggt
     7141 gatccggtgg tcgacgagtt ggagacctcc gacagccagt acggcgacca ggacgagcgg
     7201 accgacgatc gcggcctgag ctccggagcg agccaggatg cgccaggtga ccatgccgtg
     7261 cttgtgcagc tcggggagga gaccgaggat gcggcgctcc tcgcgggtcg tcgtaccggc
     7321 ggcggcgatg gtccggatgc cggtgagtga ctcggacagc agcgaagcga tgcggccctg
     7381 ggtctcctgg tacgcgaggc tgacgtcggc ggtccggcgg gcgaaggtcc acaggacggc
     7441 gatcacgagc agcacgccgc cgaagaacgc cgcggcgagc cagggatcga tgaacgcgag
     7501 caggaccagg cttccgatgg gtggcgcgat cgcggcaatc gcggtgacgg cagctggacc
     7561 ggcttgggcg gcgtcggttg cgttggcgga gacgcgggtg acgaggtcgc cggtctcgaa
     7621 atcgcgcgtg ccctcagggc cgctgtggac aacctgcttg accaggcgat gccgcaacca
     7681 ggctgtggtg tcggcgacgc aggcggcgcc cgcgaaggcg tcgacgaggt tcgccatgac
     7741 gccaagcgcg atcagggccg cggcggcgat cagccatttc gtgtagccgt cgtcagcgac
     7801 gatggagtcg accgagcggc cgaggatcgt cggcagggcg agtgtcacgc cgctggcgat
     7861 cagcgagttg aggccgatga gcggcagcca ggcgcgtcca cgcttgacca cggttttgaa
     7921 ggtgatcatg ttgtctgctc ggccaggaag gcgagcatgt ccgcggcgag accgattccc
     7981 tggctggcgg atccggcggc gtgacccgcg tccgggtcca gtctgatgag cacgggacgc
     8041 tctctaccgg tcgcgtgctg cagggcggcg cacatcttcc ttgcgtgcaa ggggtccacg
     8101 cgggtgtcgt tgccgaagac tgtgaacagc acggcggggt acttcacgcc ttcggtcacc
     8161 cggtggtacg gcgagtagga caggaggtgg tcgaaatcat ctgcattctt ggccgagccg
     8221 aactcctcgg tccaccgtgg gccgaggccg gacagctcgt agcgggtcat gtcggtgagc
     8281 ggcgccgagc agaccgcggc ggcgaagagt tccggccgct gggtcagtgc cgcggcgacg
     8341 agcaggccgc cgttcgactc accgcagagc gcgagttgag ccggggtggt ccagccctct
     8401 gcggtgaggt gctcggccgc gccgatgaag tcgtcgatga cctgctgctt ccggtctcgc
     8461 cggggcaggt gcgcggtgac gaacaccccg ccggcttcga cccaggcgag ggcgaacgcc
     8521 gagtatgtcg gggtgagatc ctggccgaaa ccgccgtacc cgtagaggat cgtcgggcgt
     8581 ggtccagttc ctggtttggc gatcgcggtg aggtggagct cggggttgca agtgagctgg
     8641 tgcgtttctg cttcggcttt cgggcccggc gcttccgacc agagcgtcgt acggccggtg
     8701 gtgtcgtcgt agcagtagac ggccgatggg gtgacgctgt cggtgtaggt gaaccaggct
     8761 tggcttccgt gggtggtgat ggtgccgatg gagccgaggc ctggcagcgg tacgtcgccc
     8821 gtgcggcggc cggtctcgcg gtcgtggatc gcgatctcac tggtcgtcgc cagcaggatc
     8881 gcgtcgtcca gaatcgcgaa tccggtgagg ggtttggtgg gggtgacgaa gtcgtgccag
     8941 acgcttgggc tggtggggtc accgatgcag agacggccgg tgggtgcgtc cttggtggtg
     9001 acgacgtaca ggcgaccatc aggtgcgact gtcatcaccg tcagcgcgtc ttgctcgacg
     9061 ggtttgggag gttcgttggt gctgaggtcg gcgagccaga ggtcgttcgt ggtgccacgc
     9121 gccgctgaga tggtgagcca acgaccgtcg gcgctgattt cgagcccgta cgacgcttcg
     9181 ccctcgagga tcgtggtgtc gccggcgtcg ttgaggcggt ggcgtcgtac ctgacggaag
     9241 cgtacgtagt agaaggcgtt tccgtcgggg agccaggcga caggggagta gcgacagccg
     9301 tcgatcgggc cgtctgttac ttgtcccgtg gtgacgtcca ggacgtagag gacggattgc
     9361 tcggtgccgc cgcgggagat ctggtaggcg accagactgc cgtccgggga gggctgccag
     9421 ctgtccagcg tggtgaggcc ggtcgggtcg agctgcatcg ggtcgatgag tgacttcggg
     9481 ccgacgtaca ggaccgggtg ttgctggccg gggtcgcggc ggagtgtgaa gcatcggtcg
     9541 cctcgccaga tgggggcgga cacggtgccg acgttggaga gggctttgac atgcgcgcgg
     9601 aagtgatagc gggtagtgag agtggtggcg tggttgagcc agaggtcgtc ctggatcgct
     9661 tgccagcgct gcgtctcagg ggaggcggag tcctccagcc agcggtacgg atcggcaacg
     9721 aggtggccgt gcaccttttc tacgagcggc agccgatgag cctgcacgtt gtcgctcctt
     9781 cctggctgcg gtggcccggc cctgggtggg tatgccgccc acccagggcc ttgtcagaac
     9841 ctggttgccc aggggccgat cagtggcaga gcagaaggct caggttgctc ggggtctgcg
     9901 aagcgcagcc cagaacggtc agcgtggaac caccggggtg gtggtggcca ccgccgtaac
     9961 ccggggtctc gagaccctga aggtcgagaa gtgccatgtt ttacacctcc ttgagtgcag
    10021 gttgtcggga tgaggactcg gaccactggg gaggtccgag gaacgggagg gacaccggcg
    10081 cctcgtgcag cgcggttccc agggccagca ggacgccggc cgatccggtt gccaggtcca
    10141 tcgagagacg gagcagctgg ttgccggggt acgcgaggcc gccggcgaac ggcagcgcat
    10201 gccagccgag cccgtagacc aggtcgtcga cctgttcacc aagcgccgag gctgtcagca
    10261 ggagaccggc gcggcccatg aacaggccgg gctgaacgta gaagtcgcag tgcgtgacct
    10321 tggtcagctc ctccagcgag cctgcgagct cgtccgatgg acggtggcgc aagtaccgct
    10381 cgacgacgag cgcgatgccg gccgaacctt cttcgagata gggcagcgtc cgccagcctt
    10441 ggttgatttg ccgcgttccg tccggcgtga tcagcgtccg tcgaaggtct tgcctgatcg
    10501 cgatctcggc caggtcgagc aggccggtgt ccccgagctg ctcgaacgcg ttgaggaaca
    10561 acagcgcggg cccggacgac ccgtacatca acccggcccg cgcatgctga ccgccactga
    10621 tctccggtac gtcggtcacg tcgccgagcc ggtccgcgac caggtcgagc acccggaccg
    10681 ccttcgcacg cagcgtcggc tcggtgtcga agtgcagcag gttcaacccg atgccggcca
    10741 ggccggagtg cagtcctagt tcgcgggagg tccagtcgtc gacgagtgtg cggtcgacca
    10801 gatccagcgc gtcctggcgg tatccgagct cgtcgaggac gtgcgccaca ccgtgcaggc
    10861 cgtcgtacag gccgggaccg gtctccgtgt ccagcgcgcg cttgcgcagc cagtcgtcgt
    10921 actgcgggaa tcgctcggcg ccggtccgct tgagtgcgta gaggacaccg gcggcgccgg
    10981 ttgcgatgtc gatgccggcg ccggggcgga actgcgcgat gtcgccgggg aacagcctgt
    11041 cggcgcgctc gggcgtggcg ctggcgacga tcgaacgggt cagcgcatcc cggacctcgg
    11101 tccacccagc cttgcccggc agggctagat cggccagctc attgccggcg tcggtgatga
    11161 tgctgacggc ttggtcgatc gttgctctag gcaccggaaa ggtctcggtg atcatctcgg
    11221 cgaggtggaa tgccttgccg ggatggagat tgagcaggat cgttgtctgc ggcgcgaaaa
    11281 cgccgagcgc gatacaggcc agcgcgtagc ggtccacctc gacgccttgc cggtctgggg
    11341 gcgccgcgta gccgggatgg gccagtgttg atctcgctct gtcctcggcg cgggtcgcca
    11401 cctcgaagtc gatgagcgtg aggttgccgt cggcatcgag caggacgttg tccgggtgca
    11461 ggtcgcagaa cacgacgccg cgctcgtgca actgcccgac cgcctgcgcg agttgctcga
    11521 cgatccgcgt ggcccattcg gcgtactccg ccttgtcggc ttcggacgca tccgggtgag
    11581 tcagcggata ccgccgtacg agctctcgtt gcagcgacac cgagtcgatg tgctcctgca
    11641 ccaagaagtg gtgctcaccg agctggagat agtcatggac cttcggtacg acgctcagtc
    11701 cgtcgagctg ctcgaggatg tcgcgctcgt ggctgatccg ggcgaccgcg tcccggccgg
    11761 acatgtcgag tccggcgtac gggcgtcctt ccttgaggac gacacggtcg ccggtctcgt
    11821 tgtggcgccc gaggtagaca ccgccgccgt tggagaactg gatgacgccg tcgatcgtgt
    11881 acgcgaggtc gttggtggtg accgcgttgc gggcttcgag atgcggctcg aggaaggccg
    11941 gcagcgtcac ccacggcggc gtcgagaacg tcgggccgcg atgatccggg accagcgtgc
    12001 cgttgtcgtc ctcgagcgcc aggacccgtt cgccggtggg tgaaaggcag tacctgctga
    12061 cgaaagcgcc gtaccggacg aacagcggac cctcggcgta gcggaggtcg ctcagaatgt
    12121 acgggccttc gacgccgtgc aggatgccgt cgagctcttt gaggatcagc tcgagctggg
    12181 cctcgtcggc cgggtagatc gtcaccagct tgccgctcga accgcgcggg gcggccttcg
    12241 agttgaccat taccagcacg ggttcgttgc ggaggaactt gaacgcgatg ccgcggggga
    12301 cgcagtactc ccacactgcc tcgagcgtgc gctccacatc ggcgagccgg gccgagacgt
    12361 ggatcttcca accctgctgg ggaagtcgca gctccgccgg cgcgtagtgc atccaggtct
    12421 cgccgggcac atgccgccag ccgtccggaa ccgggcggct gcacaacgcg aaatccggat
    12481 gctcggcacc gcgattggcg ggtgtctcgt agaaccgccg atccgcaagg cagtagaact
    12541 cgtaactctc ctgagctgtc tcgtgcatgc tcgtccgacc ccccttctcg tggtgccccg
    12601 ccatcttggg cgccaccgcc agggccggcg tagtgcacga tgtcatcact cttctgtgaa
    12661 gaacccacac actacgggtg agtaagtaga cactcttcgt tacacaaccc tcaagcctga
    12721 gcgtcaaaac ctccgtaaca agatgtcaac ccgtcccaac cccgtcacac cccgtaactt
    12781 ctcccgctct cgctcgtacc ggtgcagacc gtttgggata gggtcgggat gtgaccgggc
    12841 cggacgtcga cgacagtcgt cgtacctggc tcgacgtacg gcggtatctg gtggacaacc
    12901 ggtatcgcct cggcgtcgaa gcggccgatg agttcgctgt ggatcgccgc gtggctggga
    12961 cgccgttgct ggcgccggcc tcgtggattc catcgacgcc tatcccgctg gcgtcggtgg
    13021 agctgcagtt cgagcccgac gctgaattct ccggcgtgac gggcgctcgt gcggccctgc
    13081 cgtacgggtc ttatgccgag gcgatcgccg agctagctcc gccggctgtc ttcgagaaca
    13141 ggccgacata ccgtctgctt gatgcggatc tggcgggcgc gacgcccgtg cttcgcctgg
    13201 ggcgcggtac gtacttcgac agcatcaaca cgggcgaggc ggccgcgcac gagtatgcgg
    13261 cgcgacagct gtcgcctgat gcgccgggag gtctccgggc ggcgatcggc gatccgtggg
    13321 acgcgacgcg acggccgatc aatctcgcga tcagcacgct gaccatccgc cgggactcga
    13381 cgtcgacctt cttcctgcat tggcgcgatc cggccaaggt cgggcatgcg ggcgggctct
    13441 accaggtcgt cccctccggc atcttccagc ccagtgccga cgcgccatgg aatgaagcgc
    13501 atgacttctc cttgtggcac aacgtcgtac gcgaactggc cgaggaactg ctgggtgcat
    13561 ccgaggacca cggcagcggc gccgcaccga tcgactatca cgactggccc ttcgccgcgc
    13621 gcctgtcgac cggcctcgaa gacggttccg tacgcgcgta ctgcgtcgga ctcggggtcg
    13681 atccgttgac cttcgcaacc gacctgctga ccgtcctctc gatctccgcc gatctcttcg
    13741 acgagctctt cggtcaggtc aacgctgaca acgacgaggg acaggtactc gcgccgcagc
    13801 ctttcaccgc cgaagcaatc gacgagttcg tcaaccggaa gccgatgcaa gccgcgggcg
    13861 cggcgctgct ccaactcgcg tcgaatcacc agctgggcta gttctccggt tagcgttgcc
    13921 cacaacgatc ttgggaggac tgccgtgaag tttcttctca cctcttcggg cgtcagaaac
    13981 ccgagcatcc acagcgcgct ggccgacctg ctcgacaaac cgatctcgga gtgcactgcc
    14041 ctctgcattc ccaccgccgc gtattacttc cccgagggcc cggccatcgc ctaccgcctg
    14101 atcagcggca cgtcacaagg ccggctggtc gatctgggct ggaagtcggt gggagtcctc
    14161 gagctcaccg ctttgccgag cgtggccgag gagaactgga tcccgctggt caaggaaacg
    14221 gacgtgctgc tggtcggcgg cggcgacccc atgtacctgt gccactggat gcgcgagtcc
    14281 ggcttcgccg acctgctgcc ctcactgcgc agcgagacgg tgtacgtcgg agtgagcgcc
    14341 ggcagcatgg cagtcaccgc aagcttcggc gaaaactaca acgaccgccc agtccccact
    14401 accggcaccg agactcccct aggcctgatc gacatcgcga tctaccccca cctgaaccac
    14461 cccgccatgg aagacaccca agaagccaac atcgccacct gggccaccaa agtcccagtc
    14521 cccacctacg ccctggacga caactccgca atcaaggtca ccaacggcac catcgacgtc
    14581 accaccgaag gccactggaa actcttccag ccctaactcg ggtaggtgtg gatttcggtt
    14641 gccttgaggg tggcgtggag gtgttggccg ggggttaggt gaaggtcggc tacggcggcg
    14701 ggggttatgt cggccaggag ggtggtgggg ccggtggggg tggcgtcgag gcggactcgg
    14761 actgtgtggg cgtgttgttc tatgccagtg actacggcgg gccaggtgtt gcgagggctg
    14821 ccggttgggg gttctgggta gaggctgacg gcggtgggtg ggaaggctac gtggactggg
    14881 ccggaggcgg gttcggcgag ggtgatggtg ccgccgtcgg tcagcgcgac tgtggtgttg
    14941 gtggcggtgc ctcggtagag gttgaggcct actagttggg ctacgtagtc ggtgcgggga
    15001 cggcgggcta tgtcggtcgg gcggccttgc tggacgatgc ggccgttctc gacgatgacg
    15061 aggcggtctg cgagcaccat cgcgtccagc gggtcgtgcg tgaccaggag agtgcggcct
    15121 tcgtagcggt tcaggtgttg accgagctcg gcacgcacgt ggagcgtcgt actcgcgtcc
    15181 agcgcagcca atggctcatc aagcagcagc acggatgggc tcgttgccag cgcgcgtact
    15241 agcgcgaccc gctgggcctg gccgccggat agggctcggg gccgagagcg tgcgtacgac
    15301 gccagtccga cggcccccag ccaccgcagt gcctctgcac gcgccgcatg cttctcgacg
    15361 ccgcgggcgc ggaggccgaa ggcgacgttc tccagtgcgc tgaggtggtc gaagagcaga
    15421 tagtcctgga acaccactcc gatcggccga cggtccggcg tacggaagac gcgcggcggc
    15481 tcgtcccaga cctcgtcgtc caatgcgacg cggcctgcgc cgacaggaag cagacctgcg
    15541 atcgctcgca acgcagtcgt cttgccagcg ccattaggcc ccagcaacgc gactacctct
    15601 ccgggctcga cagtgaggtc cagcgagagg tcaaacgctc cacggctcac ccgcacgtcg
    15661 gcgtacaggg tcatcgcagc ccacttatcc agcgctcgcg gagagacgcc agtacgacga
    15721 cggacacgag caggagcacc agactcagta cgacggccac gtcggggtca gtctccaacg
    15781 ccagatacac agccagcggc atagtcgtcg tacggccggg caggttgccg gcaaaggtaa
    15841 tggtcgcccc gaactcgccc agtgcacgag cccagcacag tacggcgccc gccacgacgc
    15901 caggcgcgat cgacgggagc gtgacccggc ggaacgtcag ccaacggccc gcaccgagtg
    15961 tggcggcggc ctcctcgtag cgggggtcgg cagcacgcag tgcgccctct accgagatca
    16021 ccaggaacgg catggctacg aacgcttccg cgacgaccac tccggctgtg gtgaagggca
    16081 aggagaagcc gaaccagagg tcgaggcgtt caccgatcag tccgcgtcgt ccgaggacca
    16141 gaagcaacgc aacaccgccg acaactggcg gcagcaccag agggactgtc acgagcgccc
    16201 ggatgaggcc gcggcccggc agcgacgctc tggcgagcag ccatgccagt gggatgccta
    16261 ggagcaggca gacggtggtg gcaagagttg cgcacagtag agacagccgc agcgcctgcc
    16321 agatgtcggc actgaacaga cggctcggca gggtcgacca aggcgccttg atcagcagac
    16381 cgatcagggg gaccagcagg aacgccaggc cgaccagcgc aggcaggagg agcacaagtg
    16441 gaagctggcc gccagtccgc cgcctgacac taccggtgcg ggtgtcctgc ctgaggctca
    16501 cggcgagtcg aagcctgacg cggtcagtac tgccttgccc tggtcggaca ggacatagtc
    16561 gacgaaggcc ttggcgccgt cagcgttcgg ggccttggtc agcgtggcga tcgggtactc
    16621 gttcacagcc gtgctcgctt cggggaactc gatgccctcg accttgccct tcgccgacag
    16681 tacgtccgtc ttgtagacga gcgcggcatc gacctcaccg aggctgacct tcgtcagcgc
    16741 ggccttgacg tcctgctcca ggctgtccgg ctgcggggtg atcccgaccg ctttgaacac
    16801 cttgtccgcc gcggcgccac acggcacctg cacggcgcac agtgcgatct tcttgttctt
    16861 gtccgcgaag tccttcagcc cggtgatctt gcccgggttg ccggtcggta cggcgatctc
    16921 cagcgtgttc ttcacgaacg tcgtcggagt gttcttgtcg gccacctggt ccatgttctt
    16981 cggtgcagcc gacgcgaaca cgtccgccgg tgcgccttgg ttgatctgct gcgccagcgc
    17041 cgaactcccg gcgaagttga agttcacctt cacacccggg tgcgccttct cgaagtcctt
    17101 gcccagctgg gtgaacgagc cggtcagcga cgccgccgcg aagacgttga cggtccccga
    17161 cagagccgtc gtactggaac cgctcgacga tgcggccggg ctgtcgttgc cgcagccggc
    17221 cagggtgagc gcggcagcgg cggcgagggc ggcgagcgca gtacggcgga acatcaggcc
    17281 tccgggattt cgacgacgac atgggtggac ttgatcgagg cgacggcgac cacgcccggc
    17341 tcgagaccga gctcgtcggc agcctcgcgg ctcatcagcg agaccacgcg gaacggtccg
    17401 gcctgcagct cgacctgtgc catcacgacg tccttgacga cgcgggtgac gatgccgcgc
    17461 atgcggttcc gcgccgaggc cgcggcggtg gcgcccggct cgggtgactc agccagttcc
    17521 tgggcgaacg tcgcgagctc gcgaccctcg atcgccatcc ggccaccgtc ctggaccgac
    17581 ggcagccggc cctgctcgac ccagcgccgt acggtgtcgt cactgacacc gagcaacgcg
    17641 gccgcctcac tgatccgcaa attcggcata aacagcattc tagtgccgca gatgcggtct
    17701 cctggccatg ttttccacag tcgtcaagtc gtcacggaaa gtgtccgccg atccgcataa
    17761 gttatgggca tggagacatc ggggttgcgg gagtatctgg acgggccgta caaggcggcc
    17821 cgcgacgtcg tgcgcgccgg gctggaggcc aacccggagc tgctggactt cgcggtcacg
    17881 ctgcccacgg acgagtaccg ggacaaggtg ctcgagttgc tgcagcagat caccgcggag
    17941 gggcatccag cgcgcggctt cccgaaggag tacggcggtg agggcgacct cggcgggttc
    18001 atcgccgggt tcgagacgct cgccttcggg gacctctcgc tgatggtgaa ggcgggcgtg
    18061 cagttcggtc tgttcgccgg cgccatcctg cacctgggca ccgagcggca ccacgagcgc
    18121 tacctcgccg acgcggtcag cggccggctg ctcgggtgct tcgcgatgac cgagaccggg
    18181 cacggctcca acgtccaggc gctcggcacg acggcgacgt acgacgcctc gacgggggag
    18241 ttcgtcgtac acacgccaac cccgtcggcg cggaaggact acatcggcaa cgcggcccgg
    18301 cacggccgga tggcggcggt gttcgctcag ctcgtcgtgg gcggcgagac gcacggcgtg
    18361 cactgcctgc tggtgccgat cagagctgac gacggtacgg cgatgccagg cgtcacgctg
    18421 accgattgcg gaccgaagct cgggctgaac ggggtcgaca acgggcggat cgtgttcgac
    18481 caggtgcggg tgccacggga ggcactgctg gaccgctatg cccagatcga tgccgaaggc
    18541 aactacaaga gcgagatcga gaacccggac cggcggttct tcaccatgct cggcaccctc
    18601 gtgcaggggc gcgtctcggt cggcggcgcc gcgatcaacg cgagcaaggt ggcgctcgcg
    18661 atcgcgatcc ggtacggcga tcagcgtcgg cagttcggcg cccccgggag tgccgaggag
    18721 gcgctgctgc tcgactaccg gatgcaccag cgccggctgc tgccactgct cgcccggacc
    18781 tacgccctgc atttcgcgca ggccgagttg gtcgacgagt ttgtccggat cttcggcgac
    18841 ggcagcagcg agcacgaccg gcgcgcgttg gaggcccagg cggccgggac gaaggcgctc
    18901 gggacgtggc atgcgaccga gacgatccag acgtgccgcg aggcgtgcgg cggcgcgggg
    18961 tacctggcgg agaaccggct ggcaaccctc aaggcggaca ccgatgtatt tacgaccttc
    19021 gaaggggaca acaccgtcct gctgcagctg gtcgcgaagg ggttgctgac cgactaccgg
    19081 gagtcgttcg ggaagctgga tccactcggc actgcccggt tcatcgcggc gcaggcggtg
    19141 gagatcgcgg tcgagaaggc tgcgctgcga ccactggtcg agcggctgcg ggacgtcgta
    19201 ccgaatcgga gcggtgactc ggctgatccg gatgccgggc tgcgggacga cgggtatcac
    19261 tcggggatgc tgcggttccg ggaggagcac atgctggccg gggtcgctcg gcggctgaag
    19321 gcgggcatcg acgcgggtga cgagccgttc gaggtgttca accggtgcca ggaccatgtc
    19381 atcgcggccg ggcgagcaca tgtcgaccga gtcgtgctcg aggcgttcca ggctgcggtg
    19441 gcggacgcgc cggaggagat tcgccagctc ttgaaggacg tctgcgatct ccacgcgctg
    19501 gcgacgatcg aggcggagcg ggcgtggtac ctcgagcacg ggcggttgtc gccgggccga
    19561 tcgaaggcca tcacggcgct cgtgaacgag ctgtgcgccg tcgtccggcc ggccgcggtg
    19621 gagctggtcg acgcgttcgg cataccgggc tcggcggtgg aggtgccgat ggttgtaccg
    19681 tcgcagcatg agtgagccga tcgaacccgc gtcggccgcc gaggccgccc gtgaactcgc
    19741 ccgggtgctg ctggagcagg ccgacgctct ggacctgcac gatctgcggg ccaccggcgc
    19801 gatcgagaac gtccgggtcc aggcccgggc gctcgcggac gccgtacacg aacggggctg
    19861 gggtgacatc ttcctcggga tcgactccta cgaccccgac gagctggacg acctgccgct
    19921 ggggccggac gacttcgacg acccggagga ctaccgagag atcgtcgagg gcgacagcct
    19981 gggcgacctc gacgacctgg aggagccgct gctgccggag gacggcgtac ggctgagcta
    20041 ccaggctcgg tacgacttcg tggtgacgga tccggaggcg ttcgtgcagt acgtccggag
    20101 ccgggcggac gaggcgcaga acgacgaggt gatcgacgac atcgaggacg tgcagtcggc
    20161 gttcgagctg ctctgctacc tcgacggcct cggctccaag gactacgaca cagccggcct
    20221 caccccggcc ggcggcgagg aagcccacaa gatcgtcgaa ttctccctct gggacctaga
    20281 ccccacccgc cgcgacgaca cctacccgta ctaaccacct cgggctgcgg cgtcgagcct
    20341 cgcgcgacca gcgcccaccg ggagtactcg gtagccgagg cccccgcgag ttcacctccg
    20401 cgtgccgacg gctctggtcg tgccggggtt ctggtggcgg cgggtgagag gtgccgcccg
    20461 gacgtggggg agctttgtcg gtgcggtcgg cgtcgcgcct gggcgccgcg aggccggctg
    20521 ggcgtgccgg ggttctggag gcggccgggt ggggaatgtt gcgggttgat tgcaactcgg
    20581 ggttacatct ggggtgacgg ttgggcgggg gtgctggggg tggggtggaa gtgcctggtt
    20641 ttgtggtggt tctgttgttg cggcaggcaa catttgtacg gaaagtgaga gtttgtttac
    20701 acagcgttgt tttgttcaaa ggcaatgcaa atgtttgatc cgggggatgg tccggcgctg
    20761 tgcccgcatg acaacgttct gctgtcggcg acggacgggt cgctgacgca ggctccaggt
    20821 ggaacccgga agtactcccg tccgcgaccg gactgtacct cccctgccgg tcacggaatg
    20881 aggcaccggg cccgccctcc ttcgggccga ctgccctctc ggggcaacag caggacgccg
    20941 gtcgtgccgg ttccggtgcc ggtcgccagt gaggtggcga ccgacaccag gcacgaccgg
    21001 cgtttccctt tgccgggcag gtgtctggtg caactgggga ccagacacca ccccgggcaa
    21061 tctcacggga ccgccctgag cggcctgcgg gacgttggcg acggtctaga ccgcagcgtc
    21121 agcctgtgag gtgcgtcagt acggcgagga cccggcggtg agtgtcgggg gtgtcggtga
    21181 tgcggagctt ctggaagatg ctgcgcatgt gggtttcgac agtgcgttcg gccaggacca
    21241 gctgggccgc gatggcgctg ttcgagcggc cttcggcgac cagcgccagt acctctcgtt
    21301 cgcgcgccga tagtgccgcg agcggatcgt tcgcccgtgt tggcgtcacg agggcggcga
    21361 cgattgccgg gtcgagggcg gagccgccgt ccgcgacccg ccgcatcgcg tcgaggaagt
    21421 cggccacccg caggacgcga tccttcagca gatagccgaa cgcaccggtc ccgaccaggt
    21481 ccaccacgtg ccgcgtctcg acgtgctgcg aaagcatcag gatcggacgc tccggcacct
    21541 cgttccgcag gaccgcggcc gcccgcgccc cgtcgtccgt catcgtcggc ggcattcgta
    21601 cgtcgatgat cgtcagctcc gggtccaccg cccggaccac gctgaccagc tcgtctgcgt
    21661 cggacgccgt accggcgatg gtgtgaccgt tctcggtcag cagccggctc aaaccctcgc
    21721 gaaacaaggc ggaatcctca ccgatcacga tgcgcatggg atctccgccc ggatcgaagt
    21781 ccccgcaccc ggcgggctgt ccagggtgaa ctccccgccc acggacgcca cccgatcccg
    21841 caacgacgtc aacccgaacc cctccttcgc tccacccaca ccatcgtccc gcacgagcac
    21901 ccgcagccgc tgctccacga tctccacctc gatcgagatg cgggtcgcac gggcatgctt
    21961 cagagcgttg gcgatcgcct cgccgacggt gaagtagacg gcggtcgcga cgccctcacc
    22021 gacttccaga tcgggtacga cgaggtcgac cggaaccgag ctgtccgcca ccaagcggcg
    22081 aagagcgacc gccagaccgt catcgaggcg gctcggccgc acaccgtggg cgatccgccg
    22141 gagctccgcc acggttccct ccaccgtctc caccacctcg tcgatctccc ggtacgccgg
    22201 actgccgggc tcgagctgat actgcagcga ccgcagccgc atgcccatag cgaccagttg
    22261 ctgctgagct ccgtcgtgga gatcccgctc gagccgctga cgctccaagg cgacttcgtc
    22321 catcagtcgc gaccggctcg ctcgtacctc tgccagcgcc tcgcggagtt ccagccgcag
    22381 ccggctcacc tcgatcggca ggcgcgcctc gacggcggct tcccgtgctc gccggatccg
    22441 gcgagcggac gtcgtaccga ggacgagtgc tccgaccacg gaatcgcctg tctgcaaagg
    22501 gattgcgccc tcgggcatct cgaactgttc tccgggccgg cggagcagca cgcggagcgc
    22561 cgggtcgt
//
