LOCUS       NZ_SLWR01000003        22715 bp    DNA     linear   CON 05-APR-2024
DEFINITION  Kribbella antiqua strain VKM Ac-2541 Ga0310564_103, whole genome
            shotgun sequence.
ACCESSION   NZ_SLWR01000003
VERSION     NZ_SLWR01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kribbella antiqua
  ORGANISM  Kribbella antiqua
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 594475)
  AUTHORS   Whitman,W.B., Woyke,T., Klenk,H.P., Zhou,Y., Lilburn,T.G.,
            Beck,B.J., De Vos,P., Vandamme,P., Eisen,J.A., Garrity,G.,
            Hugenholtz,P. and Kyrpides,N.C.
  TITLE     Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase
            III: the genomes of soil and plant-associated and newly described
            type strains
  JOURNAL   Stand Genomic Sci 10, 26 (2015)
   PUBMED   26203337
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 594475)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 185.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004345665.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 04:15:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,825
            CDSs (total)                      :: 7,760
            Genes (coding)                    :: 7,713
            CDSs (with protein)               :: 7,713
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 7 of 47
            Pseudo Genes (incomplete)         :: 41 of 47
            Pseudo Genes (internal stop)      :: 3 of 47
            Pseudo Genes (multiple problems)  :: 4 of 47
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:43:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 76628
            Orig. end                         :: 99343
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SLWR01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22715
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22715
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22715
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12715](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12715)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(502..3858)
                     /gene="lysX"
                     /locus_tag="EV646_RS09805"
                     /old_locus_tag="EV646_10380"
     CDS             complement(502..3858)
                     /EC_number="2.3.2.3"
                     /EC_number="6.1.1.6"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004824 - lysine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006430 - lysyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: LPG_synthase_C (260-560). E-value:
                     2.9e-102. Score: 333.6. Matches aSDomain:
                     nrpspksdomains_EV646_RS09805_LPG_synthase_C.1"
                     /codon_start=1
                     /gene="lysX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LPG_synthase_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391542.1"
                     /locus_tag="EV646_RS09805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10380"
                     /product="bifunctional lysylphosphatidylglycerol
                     synthetase/lysine--tRNA ligase LysX"
                     /protein_id="WP_132146413.1"
                     /sec_met_domain="LPG_synthase_C (E-value: 2.8e-101,
                     bitscore: 333.6, seeds: 74, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSEQQESIPEWQQRAAVWVGRVVVAASVWSFLAIPLHLFAPAYV
                     RRVDQAFDFVGIPAGHTFFSAVYLAVVGSALLRGKRAALLWVLWVFEALWLVAQIANVA
                     FTSVRLSNPEDAELLREFGRASVVDLEWAIAQVVVVAAIIVLLWKIRAAFPARLAPGTR
                     RLAVGSLVLGLMISAAVSITLTQIFPRTLSGQREKVGWAIIAALGQSRSKMGGHEGHGW
                     IGLSVGAISAASLVIAFAIFLRSVRRVRYLTQTEELETRRLLLLYGERDSLGYFATRRD
                     KAVIFSPGNDAAIAYRVVNGVSLASGDPLGDPAAWPAAIQRWLAEARTYGWSPAVLSAS
                     EEAAHAYVDAGLRALAMGDEAIIDVADFTLEGRTMRPVRQAVTRVQRAGYHAEVVRQGD
                     LSPEVLAEYVQLAERWRGGQTERGFSMALGRLGDQADARCVMVIARDADGAVRGLLSFV
                     PWGVRGVSLDLMRRDSESVNGLMEFMVTSLVDACGDLGVHRISLNFAMFREIFSDAERV
                     GAGPVLRLTNALLTTASRFWQLESLYLSNAKYLPRWSPRLICYSRGASLAQVLLAAGTA
                     EGFLPAPRPWTRVDSVETAERHAIRAADGGGFASAVRAQEQELLRPALPDRKLTEQEQI
                     RRAKLAALVAAGIDPYPVSVPRTETLERIRELHPNLPPDHHTGQTVSVTGRVMRMRDHG
                     GLAFTQLQDGLSQLQVMLTAETCGDTALDQWRRFVDIGDHVSITGEVVTTRRGELSIAA
                     TDWLMAAKCLHPLPDKRKGFTDPEARVRQRHLDLVMNPETLRMMQHRSTAVRALRNGFE
                     SRGFIEVETPMLQAVHGGANARPFVTHINAYDTDLFLRIAPELFLKRLSVGGLGKVFEL
                     NRNFRNEGADATHNPEFTSVEAYQPYADYHVMRELTRELLIETATAVFGKPVVQRPDGE
                     IDISGDWPVITVHDAVGQATGTTIDADTPAERLRELCAEHGVHTTFELTAGELVLELYD
                     ELVEPTTTVPTFYTDFPLETSPLTRTHRTEPRLAERWDLVAFGAEIGTAYSELVDPIEQ
                     RRRLTEQSLKAAAGDPEAMSLDEDFLSALEYAMPPTGGLGIGVDRVMMMLTGQNIRATL
                     AFPFVRPAPRD"
     aSDomain        complement(2179..3078)
                     /aSDomain="LPG_synthase_C"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV646_RS09805_LPG_synthase_C.1"
                     /evalue="2.90E-102"
                     /label="EV646_RS09805_LPG_synthase_C.1"
                     /locus_tag="EV646_RS09805"
                     /protein_end="560"
                     /protein_start="260"
                     /score="333.6"
                     /tool="antismash"
                     /translation="RRLLLLYGERDSLGYFATRRDKAVIFSPGNDAAIAYRVVNGVSLA
                     SGDPLGDPAAWPAAIQRWLAEARTYGWSPAVLSASEEAAHAYVDAGLRALAMGDEAIID
                     VADFTLEGRTMRPVRQAVTRVQRAGYHAEVVRQGDLSPEVLAEYVQLAERWRGGQTERG
                     FSMALGRLGDQADARCVMVIARDADGAVRGLLSFVPWGVRGVSLDLMRRDSESVNGLME
                     FMVTSLVDACGDLGVHRISLNFAMFREIFSDAERVGAGPVLRLTNALLTTASRFWQLES
                     LYLSNAKYLPRWSPRLICY"
     gene            3968..4621
                     /locus_tag="EV646_RS09810"
                     /old_locus_tag="EV646_10381"
     CDS             3968..4621
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017959.4"
                     /locus_tag="EV646_RS09810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10381"
                     /product="DUF998 domain-containing protein"
                     /protein_id="WP_158290936.1"
                     /transl_table=11
                     /translation="MVAVPYRLMRNVMIAAGVLYCSLLLEIAAGFPLNVHYSFLSELGA
                     RDQPTSPYARAMDLGASVLLLLAAILGRPAARMNREVAGLLISAAVFGAGTLFDSFSPM
                     DCAPSANPSCHDSGTAALLHEITSTIAGVGSVVMGIFALLVLGRLGWGGPWSRVLAASA
                     AGVAVTQAWLGIETGLEVFTGDLHPPGILQRVSVLLTCLMLATALPGLRQAFLR"
     misc_feature    4220..4222
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4618..5358
                     /locus_tag="EV646_RS09815"
                     /old_locus_tag="EV646_10382"
     CDS             4618..5358
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (58-237). E-value:
                     2.3e-12. Score: 39.0. Matches aSDomain:
                     nrpspksdomains_EV646_RS09815_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="EV646_RS09815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10382"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_158290937.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.1e-13, bitscore:
                     45.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.9e-08, bitscore: 29.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTWIVLPGLAETPEEFGRVVELLPGLDLRVIDPWRTPITSTVD
                     ELRTAAGVAPEAEIGLIGHSIGGLAALRWALTRPLEVTRLVLVDTSLTSETGFRWLYPG
                     TRADRAIRAFLRFLGRIGLPQLLGTALRRLFVRIGSRSNHDLLSKATAKERYGAALSWL
                     LFWDELANSWELAAEVGKLVTELVSPTTLLVATGGSSRFTANRWLACQQRLADALHGTV
                     EVLPDSAHLMHLDRPDAIATAVRG"
     aSDomain        4792..5328
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV646_RS09815_Abhydrolase_1.1"
                     /evalue="2.30E-12"
                     /label="EV646_RS09815_Abhydrolase_1.1"
                     /locus_tag="EV646_RS09815"
                     /protein_end="237"
                     /protein_start="58"
                     /score="39.0"
                     /tool="antismash"
                     /translation="IGLIGHSIGGLAALRWALTRPLEVTRLVLVDTSLTSETGFRWLYP
                     GTRADRAIRAFLRFLGRIGLPQLLGTALRRLFVRIGSRSNHDLLSKATAKERYGAALSW
                     LLFWDELANSWELAAEVGKLVTELVSPTTLLVATGGSSRFTANRWLACQQRLADALHGT
                     VEVLPDSAHLMHLDRP"
     gene            complement(5355..6581)
                     /locus_tag="EV646_RS09820"
                     /old_locus_tag="EV646_10383"
     CDS             complement(5355..6581)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391545.1"
                     /locus_tag="EV646_RS09820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10383"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_241995693.1"
                     /transl_table=11
                     /translation="MSKGTVGGGTTMLRRINVAAVLDAVRRSAPAPLRVAELVERTGLA
                     RPTVAQAVDELLDAGWLQQHGPDSADRSLGRPAIRVSLRGRAAPVLGLDVGPHRVTVGV
                     SDLAGRKLALVRRSGPGWSAQELLGVISEVITEALAEADVRAEDIAAAVAASPGIVDEH
                     TGRVQLVPSVPGWSAIDLTKHVRSLLDCPVMLDNDANLAALAIAAARGGTGTLLAVQWG
                     ERLGAGIVIDGRLHRGTGAAGEIGFIATAPDDVINPEDSRGPLERAVGSEAIAALGRQA
                     ALDSPDSRLAELGGEQLDTADVFAAAAERDPVAQAVVQQVARDFARALAPAVLVLDPTA
                     VVIGGGVARAGAVLLDAISDQLRMLTLNQPKLELSALAEDAVVTGAMRMALDEVWQRKL
                     PTPALTSTA"
     gene            complement(6751..9675)
                     /locus_tag="EV646_RS09825"
                     /old_locus_tag="EV646_10384"
     CDS             complement(6751..9675)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391546.1"
                     /locus_tag="EV646_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10384"
                     /product="AAA family ATPase"
                     /protein_id="WP_132146425.1"
                     /transl_table=11
                     /translation="MQTRAPRVVGRDREIDHLHRLLASAAGGHGGAVFLVGEPGIGKSR
                     LAGVATTRAIDSGMATLRGRVGAIGTMVAFRPFTEALLSLIRRGEMPAADGLGPYRQVL
                     GRLVPDWDDGTAHDTATSAVVLGEAVLRLLALVGKDRGCLLVLEDLHGSDPETLAVIEY
                     LLDNLDEQPITLVATLRSETCAALELARLSAQRGSAALIELQPLDRAEVGELASGCLEV
                     PVSGVPDHLVDRLWQDSAGVPFIVEELLQEATRSGQLLSKPDGSVQVVDGLQTGVPAAV
                     VRSISSRTDQLGPQSRDLLVLAAVIGHRFPLSVVRKATGTDERLLLATLRAGLAAQLVG
                     PDEPVPDWYAFRHPLTADALLAGLTPTERATLARRCADAIEELHPGLPGEWCPMVAELA
                     ETGGDKGRAGRLFATAGRRSFDEGAMGSAVKLLERANALLAGEADSTHRAEVLGSLLIA
                     LSETGQFENSAEHAATIEDMANRNLDSRKVAALHVQLANLEHMAGRWSAALTQVATART
                     LLGVDAGDADLAPVDAIAAHLELARTSPGRLKAATELATRAAEAAERAKLPAVACDALQ
                     LLGILSREHDLDRSIDYFHRARLVAEEHNMTFQRVCSHIFQAGTICLAGGSIVELERAR
                     QQALRIGAIPLAYEVDGILGQQAILRSEYDKARVLIDECLEVTRRLRLGRSATYFLSTK
                     AILEAHQGRRTAMEATLAEAANWGGERASYELPYSYGLARTFCALLEENRELADSEMAQ
                     ALAYDAQNPTTLHTSGKYGLGLLLGVLSGRNGWAHFEAITAAAASGMRWNKQFVQLAHA
                     VLLGRDGQVEAANAKMLEALETASLYPMARHLGLRMVAEPAHADGWGEPVAWLRQAEDY
                     FHNAEIPAVASACRSLLRQLGATVQQRRIGSEQVPAHLRQLGITTREYEVCRLLVDRIG
                     NKSIASRLHISPRTVEKHVASLMTKTQQPDREALSSFARTVLAD"
     misc_feature    9763..9776
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.97"
                     /tool="antismash"
     misc_feature    complement(9763..9776)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            complement(9786..10004)
                     /locus_tag="EV646_RS09830"
                     /old_locus_tag="EV646_10385"
     CDS             complement(9786..10004)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV646_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV646_10385"
                     /product="hypothetical protein"
                     /protein_id="WP_132146428.1"
                     /transl_table=11
                     /translation="MTAQHHTAQDQDGKYDAEPQTDGIDPIGPITLPKRNKVGARAMAL
                     VGTVGMSAFAIAVAATDYSSTWPTIES"
     gene            complement(10001..12715)
                     /locus_tag="EV646_RS09835"
                     /old_locus_tag="EV646_10386"
     CDS             complement(10001..12715)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391549.1"
                     /locus_tag="EV646_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10386"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_241995695.1"
                     /sec_met_domain="DUF4135 (E-value: 4e-101, bitscore: 334.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.7e-26, bitscore:
                     85.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRCLEPLLASARRDLAAAGHPGVLAEQFLHRLGLRLVKLASRTLV
                     LELARARDRGALAGDTPAERFLDFTHRLVGGSELAEFLAAYPVLARVLGESCRQGVEGH
                     LELLARLAEDRESLVAGLLGGRDPGALTAIDPGGDPHRGGRSTATLTFADGRRLVYKPR
                     PLDLHQHFNELVDWLNTKTGLDISTVDLLPRPGYGWLEYVVHRPCNDLSDVRRFYHRQG
                     ALLALLYVLDGTDMHYENLIAVGDQPVLVDIETLFHPSHNLVGTLSRDPAYRSLLSSVY
                     RTALLPLLVSGEHGVVDLSGLGGDADATAPSSVVDWADAGLDSMHLVRRPGKTKGAGNR
                     PLLDGVYMEPRDHEIAVLTGFRAAYEAIVWHRDELIGLLRCCAQDEIRFVPRSTNLYTT
                     LLDEATHPDALRDAAGRSQLLDLLWDADESLHAIVPYELADLWAGDVPLFTTRPDSRDV
                     WASDGTRIPNVLTTEGLTTVEAKVQQLSDIDEHRQKWLISASLATRPEPVVHAATASRP
                     DVGATEADPEQLLAAATDIADEIMAQVLSEHGGPANWLGLELLDDHHWAVRPMGAGLSH
                     GYTGTALFLAQVGVLTGAHKYCELARDAIRPIPTLLENLAADLESAQLVGPGLHGLGGI
                     SYGLNRLCSLLGDAELTNWLAAALELTEQLKPEPTEFPTYAEGAAGGLTAMQSIHGLPS
                     ATRLAKRYADELVNTVELGVRRGRVAAASGFARGYQGIAWALGQYGVPGDKYADAARTA
                     ADLDRRVRPGGHGWCSGDAGTALARLSAGVPADLDAYLRAATERPVLADLSLCHGELGA
                     VEPIVWLAARDHAAVEGVRRRRAGLVLAAVQQYGPQCGTPRAVPSPGLLTGLAGIGYGL
                     LRLAFSERVPSVLLLEPTSGPKRSAHTTQGRQQ"
     CDS             complement(12756..12983)
                     /gene="allorf_089384_089611"
                     /locus_tag="allorf_089384_089611"
                     /protein_id="allorf_089384_089611"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAACASAQLSDRPARPDRPAQSLVVRRYASARGEPHRPALGGVRG
                     AQYLHHPDRVCRRSQPCRDRSYRQPHIRWG"
     CDS_motif       complement(12846..12983)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAACASAQLSDRPARPDRPAQSLVVRRYASARGEPHRPALGGVRGA"
                     /locus_tag="allorf_089384_089611_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12756..12845)
                     /prepeptide="core"
                     /locus_tag="allorf_089384_089611_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.30"
                     /molecular_weight="3668.1"
                     /monoisotopic_mass="3665.8"
                     /core_sequence="QYLHHPDRVCRRSQPCRDRSYRQPHIRWG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAACASAQLSDRPARPDRPAQSLVVRRYASARGEPHRPALG
                     GVRGA"
                     /leader_location="[12845:12983](-)"
     gene            13380..14453
                     /locus_tag="EV646_RS09840"
                     /old_locus_tag="EV646_10387"
     CDS             13380..14453
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924075.1"
                     /locus_tag="EV646_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10387"
                     /product="MsnO8 family LLM class oxidoreductase"
                     /protein_id="WP_132146434.1"
                     /transl_table=11
                     /translation="MLSPVTPGLPVSAHSVLDVVPQLAGQSAAAALRETAEVAQAADDL
                     GYRRFWVGEQHGVRGVGSAAPAVLAAVLAARTDRIRLGAGGVLLTNHQPLVVAEQFAAL
                     AAAYPSRIDLGVGQQFGLVASTAAALGAAGRDTFPQRLDELCGFLRDGLPGRAPVGDVR
                     LSLAGLPPPVFVLADHPGAAAIAAVRGLPVFLAHHCAAATTATAVAAYRDHFEATGPSV
                     KPYLAVTVGVVAADSEEEAIIRFAEYVRVKSRLAAASPRATPGELMELLEPPLTGRERG
                     KAERLLDDPGHIVGSRATVVSGLGTLVAETGADEIMLIPLAFDGLVRSAILRTIAAGLT
                     RTVRTVPRHAPPLIATA"
     gene            14476..15936
                     /locus_tag="EV646_RS09845"
                     /old_locus_tag="EV646_10388"
     CDS             14476..15936
                     /EC_number="1.2.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924074.1"
                     /locus_tag="EV646_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10388"
                     /product="NAD-dependent succinate-semialdehyde
                     dehydrogenase"
                     /protein_id="WP_132146437.1"
                     /sec_met_domain="Aldedh (E-value: 2.6e-168, bitscore:
                     555.4, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSEREVIEACPTELFIGGKWQASASGKTLDVEDPATGTALCEVA
                     DASPADGVAALDAAVAAQEDWAAVAPRERGEVLRRTYELMTERADELALLMTLEMGKPV
                     AESKAEIAYAAEFFRWFAEEAVRIDGGYQVAPNGKGRFLVMRQPVGPCLLVTPWNFPAA
                     MGARKIGPAVAAGCTMVMKPASQTPLSMLKLAELMTEAGLPAGVLNVITTSDAGGVMEP
                     LIRDGRARKLSFTGSTQVGRKLIEQAAEQVLRTSMELGGNAPLLVFEDADLDKAVDGAM
                     LAKMRNGGEACTAANRIYVQSSVMDEFATRLTERMSALKVGRGTEDGIDVGPLIDAKQR
                     DKVKDLVDDAVAQGARVLTGASVAAGNGYFYQPTVLADVPTSARLQKEEIFGPVAPLTA
                     FETEDEAVRMANDTEFGLVSYLFTNDLARALRVSERLETGMIGLNQGIVSNPAAPFGGV
                     KQSGLGREGGSAGIDEYLEIKYVAVNLD"
     gene            complement(15955..16962)
                     /locus_tag="EV646_RS09850"
                     /old_locus_tag="EV646_10389"
     CDS             complement(15955..16962)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022702.4"
                     /locus_tag="EV646_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10389"
                     /product="DUF3048 domain-containing protein"
                     /protein_id="WP_158290938.1"
                     /transl_table=11
                     /translation="MTLLILSGCSQLNANTPSESPAPVSTTPPSDGAVSMAGRAPLTGV
                     PVKEVPTRPALAVKISNTTDAHPQRGLGDADLVFVEPITGSTTRLAAIFQSKLPAQIGP
                     VRSLRPTDAALLGPTRGIVADTMADRWVLTYFEKVTDVDDRGTLVVPPDTYRIDSRRRA
                     PNHVFAQPAKLLTLTKRTAPAPYFSYAPGIAESSARLGTPATSVRIGYGGSSTATWTYQ
                     AKTKRWTRAEQWAPHMIEGGGQVAADNVLVLRAAPDHSFPQAKKSMSILDFTDTSGQLQ
                     LFTGGKVVTGRWTKAGVNDPFAFTGPDGKRLLLTPGTTWVECALTTMAVQVGRG"
     misc_feature    16980..16994
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.19"
                     /tool="antismash"
     gene            complement(17024..17896)
                     /locus_tag="EV646_RS09855"
                     /old_locus_tag="EV646_10390"
     CDS             complement(17024..17896)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924070.1"
                     /locus_tag="EV646_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10390"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_241995706.1"
                     /transl_table=11
                     /translation="MRLRRGKCAAVAVVVLLSGCADTESSTGVVSASTPPTVSASTPPS
                     ASADTPTTGSASTPATATPRAQLMPLVQHGPRDKPRVALTFDADLTALMRKRLVSGKVK
                     SYYNEKLIDELRAMHVPATLFLTGMWMEQYPDVTRQLAADPLFELGTHTYDHRGFTKHC
                     YTLGTVPRADMLSDVRRAVVLLDRLDPHPTRWFRFPGGCYDGTALHELAPAGVTAVGLD
                     VPGADGFAKGPEPIVKQVLSNVRNGSIVVLHMHGGDNAPYTAEAIGPIVKTLRARGYQL
                     VTITELMRG"
     gene            17959..18393
                     /locus_tag="EV646_RS09860"
                     /old_locus_tag="EV646_10391"
     CDS             17959..18393
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV646_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV646_10391"
                     /product="hypothetical protein"
                     /protein_id="WP_132146443.1"
                     /transl_table=11
                     /translation="MTITTDFWATTAQIIPALLLAIAVWDQSFGERDDSPRSYDIAGEW
                     VRLFHILSIGLGVLGEFVALNGLLDGGSRWAARLVVLAIGLLSQVLVGLLTIRIYNRNR
                     NTEAMDQSCLRLLHSLVVALMCLAATLSSLIAAIWLAIRI"
     gene            complement(18394..20862)
                     /locus_tag="EV646_RS09865"
                     /old_locus_tag="EV646_10392"
     CDS             complement(18394..20862)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924064.1"
                     /locus_tag="EV646_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10392"
                     /product="glycoside hydrolase family 2 protein"
                     /protein_id="WP_241995708.1"
                     /transl_table=11
                     /translation="MNTVPLTTEGGVAWTVRAIDGPVPDGISTPVAATVPGEVHTDLLA
                     AGVIPDPFDGDNESKLAWIGRTSWSYRTSFDWVADGNDIQELVADGLDTVATVTLNGRE
                     LGTTQNQHRSYRFLIGDVLVAGRNELVIDFAGPVASAEQIEAEAGGWPHTNHHPYNALR
                     KMASNFGWDWGPDVATVGIWQPIRIESWSGVWISSVRPLASVEGDRGVLNTHVDLAWAG
                     GSTEDATITVEVGGTTTELTVAAGTSTATITSAVEGAQVWWPRGHGEQNLYDVTVSVGQ
                     DTWHGRVGFRNVSLDVAPDNHGSPFVISVNGKPIYVRGANWIPDDAFVTRLSRTTYETS
                     IQDAVDAGMNLLRVWGGGIYESDDFYDICDEQGILVWQDFLFACAAYSEDEPLRGEVEA
                     EARQAITRLSKHASLALWNGNNENIWGYVEWGWRVPLAGRAWGEGYYFDLLPALVAELD
                     PRTPYSPGSPYSYDHFIHPNDERTGTMHIWDVWNQVDYTTYRKYKPRFASEFGFQGPPA
                     WSTLTSVVHDEPLDPYGEQMLVHQKAFEGNLKLERGLGEHLPKWKNDRGGGAGNAANMA
                     DWHWTTQLNQARAIVFGIEHFRSLFPLNTGAIVWQLNDNWPVVSWAAVDGHGIRKPLWY
                     ALKRVYAERLLTVQPREDELVVATHNDTDVLWSTEVTVKRRSTRAGGDVIAQETFALEV
                     APRSAVLSSLPGSVAKPTDPTREYLEVRGADGSSTYWYFAEDTELHLEGNAYAASVTKT
                     DDGYDVTVTASALAKDLALFPDRLDPAARVDSGLVTLSAGESHTFHVTGGTAPTSVGIP
                     VLRSANDLVN"
     gene            complement(20962..22059)
                     /locus_tag="EV646_RS09870"
                     /old_locus_tag="EV646_10393"
     CDS             complement(20962..22059)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924063.1"
                     /locus_tag="EV646_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_10393"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_132146446.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 5.3e-21, bitscore:
                     70.7, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 4.3e-17,
                     bitscore: 57.5, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVGVGVIGAGVISDAYIKSMQSFPDLKVVAIGDLRPEAAKDKA
                     EQYGIETHGGPEAVLNHPDVEIVVNLTIPIAHVEVALAAIAAGKHVWSEKPFSLDQESG
                     LKLLATAQDAGLRLGCAPDTILGPGLQESRRIIERGDIGQPLTALTLMQSPGPESWHPN
                     PAFLFQEGAGPLWDIGPYYLTTLVQLFGPVAAVAGLGSKSREKRTIGSGPLAGTDFDVT
                     VPTHVSAIARFESGQSSQSIFSFDSPLPRAGFVEITGSEATLAVPDPNRFDGEIKIRRR
                     DGEDWETVATTEATAERGTGVLDMARAIRENRPHRATGALAFHIVDVMASITESIDTGA
                     FVDVNSTVEVAAILPDDWDVNAATL"
ORIGIN
        1 ggaccgttcg gtcccgcccg gcgaacccgg ctcgctgctc acccgcggtc cctacacacc
       61 ccgcggctac tacaaggccg agcagcagaa cgcgcgcgcc ttcacccccg acggctggta
      121 ccgcagcggc gacatctgcc gcgtagttgc cggtggcaac ctcatcgtcg agggcaggga
      181 caaggacatg atcaaccgcg gcggcgagaa gatctccgcc gaggaggtcg agaacctcac
      241 ctacaccctc gccggcgtcc agcaggtcgc cgccgtcgcc atgcccgacc cccgcctcgg
      301 cgaacgcgtc tgcgtgtacg tcgtcccccg cgaaggcacc gccatcacgc tcgaggacgt
      361 ccgccactcg atggaacaac tcggcgtcgc ggcgtataaa ctccccgagc gcctggtcct
      421 caccaacgaa ctccccacca caaaggtagg caaaatcgac aaggcagcgc tacgcgccga
      481 catcgccgcc cggctggagg tctagtcgcg cggggctggg cggacgaagg ggaaggccag
      541 ggttgcgcgg atgttttggc cggtgagcat catcatgacg cggtcgacgc cgatgccgag
      601 gccgccggtg ggtggcatgg cgtattccag agctgacagg aagtcttcgt ccagggacat
      661 ggcttcgggg tcgccggcgg ctgccttcag ggactgctcg gtgaggcggc ggcgttgttc
      721 gatcgggtcg acgagttcgg agtacgccgt accgatttcg gcgccgaagg cgaccaggtc
      781 ccagcgttcg gccagacgtg gctcagtgcg gtgcgtccgc gtcagcggcg acgtttccag
      841 cgggaagtcg gtgtagaagg tcggcaccgt cgtcgtcggt tcgacgagtt cgtcgtacaa
      901 ctcgagcacc agctcgccgg cggtcagctc gaaggtcgtg tgtacgccgt gctccgcgca
      961 cagctcgcgg agtcgctcgg ccggggtgtc ggcgtcgatc gtcgtaccgg tggcctggcc
     1021 gacggcgtcg tgcacggtga tgaccggcca gtcgcccgag atgtcgatct cgccgtccgg
     1081 gcgctgcacc accggcttgc cgaacaccgc ggtcgccgtc tcgatcagca gttcgcgggt
     1141 gagttcgcgc atcacgtgat agtcggcgta cggctggtag gcctcgaccg aggtgaactc
     1201 cgggttgtgc gtcgcgtcgg cgccctcgtt gcggaagttg cggttcagct cgaacacctt
     1261 gccgagcccg ccgacactga gccgcttgag aaacagctcg ggtgcgatcc gcagaaacag
     1321 gtcggtgtcg taggcgttga tgtgggtcac gaacggccgc gcgttcgccc cgccgtggac
     1381 cgcctgcagc atcggcgtct ccacctcgat gaacccgcgc gactcgaaac cgttgcgcag
     1441 ggcccgcacc gccgtactgc ggtgctgcat catccggagc gtctccggat tcatcaccag
     1501 gtcgaggtga cgctgccgga cccgcgcctc cggatcggtg aaccccttgc gcttgtcagg
     1561 caagggatgc aggcacttgg ccgccatcag ccagtccgtc gccgcgatgg acagctcgcc
     1621 gcgacgcgtg gtgaccacct cgccggtgat gctgacgtgg tcaccaatgt cgacaaatcg
     1681 ccgccactgg tcgagcgccg tatcgccgca ggtctcggcc gtcagcatca cctgcagttg
     1741 cgacagcccg tcctgcagtt gcgtgaacgc caggccgccg tggtcccgca tccgcatcac
     1801 gcgaccggtg acggaaaccg tctggccggt gtggtggtcg ggcggcaggt tcgggtgcag
     1861 ctcccggatc cgctcgagcg tctccgtccg tggcacgctg accgggtacg gatcgatgcc
     1921 agcagcaaca agtgccgcca gcttggcccg gcggatctgc tcctgctcgg tcagcttccg
     1981 atccggcaat gcaggccgca gcagctcctg ctcctgcgca cgtacggcgc tcgcgaaccc
     2041 gcctccgtcc gccgcacgga tcgcgtgccg ctcggccgtt tcgacactgt ccacgcgggt
     2101 ccacggccgc ggcgcgggca ggaagccctc ggcggtcccg gccgcgagca gcacctgggc
     2161 gagcgacgca ccacgcgagt agcagatgag ccttggcgac caccgcggca ggtacttcgc
     2221 gttcgacagg tagagactct ccagttgcca gaagcgcgac gccgtcgtga gcagcgcgtt
     2281 ggtcagccgc agcaccggcc cggcgccgac ccgctccgca tcgctgaaga tctcccggaa
     2341 catcgcgaaa ttcagcgaga tccggtggac acccagatcc ccgcacgcgt cgaccagcga
     2401 cgtgaccatg aattccatca ggccgttcac cgactcggaa tcacgccgca tcagatccag
     2461 cgaaaccccg cgaacacccc acggcacaaa cgacagcaga ccacgtacgg cgccatccgc
     2521 gtcgcgagcg atcaccatca cgcagcgcgc gtccgcctga tcacccaacc gcccgagcgc
     2581 catcgagaag ccacgctcgg tctgcccgcc gcgccaccgc tcggccagtt ggacgtactc
     2641 agccagcacc tcaggcgaca ggtcgccctg ccgaaccacc tcggcgtggt agccggcccg
     2701 ctggacccgc gtcaccgcct gccggaccgg tcgcatcgtc cggccttcca gggtgaagtc
     2761 ggcgacgtcg atgatcgcct cgtcgcccat cgccagcgcc cgcagcccgg cgtcgacgta
     2821 cgcgtgcgcg gcctcctcgc tcgcggacag cacggccggg gaccagccgt aggtgcgagc
     2881 ttcggcgagc cagcgctgga tcgcggccgg ccaggcggct ggatcgccga gtggatcgcc
     2941 actggcgaga ctgaccccgt tgaccacgcg ataggcgatc gcggcgtcgt tgccggggga
     3001 gaagatgacc gccttgtccc ggcgggtggc gaagtacccg agcgagtcgc gttccccgta
     3061 caggaggagc aggcggcggg tttcgagttc ctcggtctgg gtgaggtagc ggacccggcg
     3121 gacggaccgc aggaagatgg cgaaggcgat caccagcgac gcggccgaga tcgcgccgac
     3181 cgacagaccg atccagccgt gcccctcgtg gccgcccatc ttgctgcgtg attgcccgag
     3241 tgcggcgatg atcgcccagc cgaccttctc ccgttgaccg gacagcgtcc tggggaagat
     3301 ctgggtcagg gtgatgctga ccgcggccga gatcatcagc ccgaggacga gcgagccgac
     3361 cgccagccgc ctcgtcccag gcgccagccg ggccgggaac gccgcgcgga tcttccacag
     3421 cagcacgatg atcgcagcga ccacgacgac ctgcgcgatg gcccactcga ggtccaccac
     3481 actcgcgcgg ccgaactcgc gcagcagttc ggcatcctcc gggttgctca gccgcacgct
     3541 ggtgaaggcg acattggcaa tctgcgcgac cagccagagc gcctcgaaga cccacagcac
     3601 ccagagcagc gcggctcgct tgccgcgcag cagcgcgctg ccgacgacgg ccaggtagac
     3661 ggcggagaag aaggtgtgcc cggccgggat gccgacgaag tcgaaggcct gatcgacccg
     3721 tcgtacgtac gccggcgcga acagatgcag cgggatcgcg aggaacgacc agaccgaggc
     3781 cgccaccacg acacgtccga cccagacagc agcacgctgc tgccactcgg gaatcgactc
     3841 ctgctgttcg gaccgcacca agcgatcatc ccacttgtcc tcggaggttc cggtggacct
     3901 agcactaccg agacggtgta cctgaagcga cagtcaaatg cttggcctct gtgcgaggct
     3961 gacgggcatg gtcgccgtcc cgtatcgcct gatgcgtaac gtgatgatcg ccgcgggggt
     4021 gctgtactgc agtctgctcc tggagatcgc ggccggattc ccgctcaacg tgcactactc
     4081 gttcctcagc gaactcggtg cccgcgacca gccgacttcg ccgtacgcgc gggcgatgga
     4141 cctgggtgcg agcgtgctcc tgctgctggc cgcgatcctt ggccggccgg ccgctcggat
     4201 gaaccgggag gtcgccggat tactgatcag tgcggcggtt ttcggcgccg gaacgctgtt
     4261 cgactcgttc tccccgatgg actgcgcgcc gtcggccaac ccgtcctgcc acgactccgg
     4321 caccgccgcg ctgctccacg agatcacgtc gaccatcgcc ggcgttggca gcgtcgtcat
     4381 gggcatcttc gcgctcctgg tcctcggccg cctgggctgg ggcggcccat ggagccgcgt
     4441 gctcgcggca tccgcggccg gtgtcgcggt gacccaggcg tggctcggga tcgagaccgg
     4501 tctcgaagtg ttcaccggcg acttgcaccc gccaggcatc ctccagcgcg tttcagtcct
     4561 gctgacatgc ctaatgttgg cgacagccct acccggcctc aggcaagctt tccttcgatg
     4621 acaactacct ggatcgtgtt gcctgggctg gctgagactc cggaggagtt cggccgggtc
     4681 gtcgagctgc tgccggggct cgatctgcgg gtgatcgatc cgtggcgtac gccgatcacg
     4741 tcaacggtcg acgagttgcg tacggcggcc ggagtcgcgc ccgaggcgga gatcgggctg
     4801 atcggccact ccatcggcgg cctcgcggcc ctgcgatggg cgctgacccg gccgctggaa
     4861 gtgacccggc tcgtgctcgt cgacacgagc ctgacctcgg agacgggctt ccgatggctg
     4921 tatccgggca cgcgcgctga ccgggcgatc cgggcattcc tgcgcttcct gggccggatc
     4981 ggcctgccgc agttgctggg caccgcgcta cgacgcctgt tcgtccgcat cggcagcagg
     5041 tcgaaccacg acctgttgtc caaggcaacc gcgaaggagc ggtacggcgc cgcgctgtcg
     5101 tggctgctgt tctgggacga gctggcgaac agctgggagc tggccgccga ggtcggcaag
     5161 ctggtcaccg aactggtctc gcccacgacc ctgctggtgg cgaccggcgg cagctcccgc
     5221 ttcaccgcca accgctggct cgcctgtcag caacgcctgg ctgacgccct ccacggcacg
     5281 gtcgaggtcc tccccgactc agcccacctc atgcacctgg atcgcccaga cgcaatcgcc
     5341 accgccgtcc gcggctaggc agtgctggtc agcgctgggg tcgggagctt gcgctgccag
     5401 acctcgtcga gtgccatgcg catggctccc gtgaccaccg cgtcctcagc cagagcggac
     5461 agctccagct tcggctggtt cagcgtgagc atccgcagtt ggtccgagat ggcatccagc
     5521 agtacggcgc ccgcacgggc cacgccgcca ccgatcacga ccgccgtcgg gtccagcacc
     5581 agtacggcgg gagccagagc ccgggcgaag tcgcgcgcca cctgctgtac gacggcctga
     5641 gccaccgggt cacgctctgc cgcggcggcg aacacatccg ccgtgtccaa ttgctcgcca
     5701 cccagctcgg ccaggcggga gtcggggctg tcgagtgcag cctggcggcc gagcgccgca
     5761 atggcctccg agccgactgc acgctccaga ggcccccggc tgtcctcggg gttgatcacg
     5821 tcgtcgggcg cggtcgcgat gaagccgatc tcaccagccg cgccggtgcc ccggtgcagc
     5881 cgtccgtcga tcacgatgcc ggcacccagc cgctcacccc actggaccgc cagcagcgtg
     5941 ccggtgccac cgcgggcggc agcgatggcc agcgcggcca ggttggcgtc gttgtcgagc
     6001 atgaccgggc agtcgagcag actgcggaca tgcttggtca ggtcgattgc agaccagccc
     6061 ggaacgctcg ggaccagctg gacccggccg gtgtgctcgt ccacgatgcc agggctggcg
     6121 gcgaccgctg ccgcgatgtc ctcagcccgt acgtcggcct ccgccagagc ctcggtgatc
     6181 acctcactga tgactcccag caactcctgc gcgctccagc ccggcccaga gcgtcgtacc
     6241 agggcgagct tgcggccggc caggtcggag acgccgacgg tcacccggtg cgggccgacg
     6301 tccaggccga gcaccggcgc ggcgcggccc cggagggaga cgcggatggc cgggcggccg
     6361 agcgagcggt ccgcggagtc cgggccgtgc tgctggagcc agccggcgtc cagcagctcg
     6421 tcgacggctt gcgccacggt cggtctggcc aggccggtcc gctcgaccag ttcggcgacg
     6481 cgcagtggtg cgggcgcgga gcggcgtacc gcgtccagga ccgcggcgac gttgatccgg
     6541 cgcagcatcg tcgtgccgcc gccgaccgtt cccttgctca tgtccgaccc cttgcctgcc
     6601 actcgcctat cctaatagaa agcgagcgtt cataacttac atttgcctgg cgcaccggcg
     6661 ggcggttacc gacagcgtga gtcgacaact atcaccctcc ggtcatcgca cgtcccagca
     6721 cacgcatcag gtccggaatc ggaccagcgg tcagtccgcc agaacggtcc gggcgaaact
     6781 gctcaaggcc tcccgatccg gttgctgggt cttggtcatc aggctggcca catgcttctc
     6841 cacggtccgc ggggagatgt gcagccggga cgcgatcgac ttgttgccga tccggtccac
     6901 cagcagccgg cagacctcgt actcgcgggt ggtgatcccg agctggcgca gatgcgcggg
     6961 cacctgctcg ctgccgatcc gccgctgctg caccgtcgca ccgagctgac gcagcaggct
     7021 ccggcacgca ctcgctacag ccgggatctc cgcgttgtgg aagtagtcct ccgcctgccg
     7081 cagccaggcg accggctcac cccacccgtc ggcgtgcgca ggctccgcca ccatccgcag
     7141 ccccaagtgg cgggccatcg ggtagagcga cgccgtctcc agcgcctcca gcattttggc
     7201 gttggctgcc tccacctgac cgtcccgtcc gagcagtacg gcgtgtgcca gctgcacgaa
     7261 ctgcttgttc caccgcatcc cactggccgc ggccgcggtg atcgcctcga agtgtgccca
     7321 gccgttgcga ccggacagca ctccgagcag gaggcccagc ccgtacttac ccgacgtgtg
     7381 cagtgtcgtc gggttctgag cgtcgtacgc gagggcttgc gccatctcgg agtcggccag
     7441 ttcgcggttc tcctccagca gcgcacagaa cgtccgggcc agcccgtagg agtacgggag
     7501 ctcgtacgac gctcgctcgc caccccagtt ggccgcctcc gccagcgtcg cctccatcgc
     7561 cgtacgacgg ccttggtgtg cttcgaggat cgccttcgtg gagaggaagt acgtcgccga
     7621 gcggccgagc cggaggcgcc gggtcacctc caggcactcg tcgatgagaa ccctcgcctt
     7681 gtcgtactcg gaccgcagga tcgcctgctg gccgaggatc ccgtcgacct cgtaggccag
     7741 ggggatggca ccgatccgca gcgcctgctg ccgggcccgc tccaactcga cgatgcttcc
     7801 tcctgccagg cagatcgtgc cggcctggaa gatgtgcgag cacacccgct ggaaggtcat
     7861 gttgtgctct tcggccacca gccgggcgcg gtggaagtag tcgatcgacc gatcgaggtc
     7921 gtgctcgcgg gacaggatgc cgagcagttg cagcgcgtca caggcgaccg cgggcagctt
     7981 ggcccgttcg gcggcctcgg cggcccgggt ggcgagctcg gtggcggcct tgagccggcc
     8041 gggacttgtg cgggccagct cgaggtgtgc ggcgatagcg tccaccggcg ccaggtccgc
     8101 gtcgccggcg tcgacaccga gcagcgtccg cgccgttgcg acctgcgtca gggctgccga
     8161 ccagcggccg gccatgtgtt cgaggttggc cagctggacg tgcaatgcgg cgaccttgcg
     8221 gctgtccagg ttgcggttgg ccatgtcttc gatcgtcgcc gcgtgctcgg cgctgttctc
     8281 gaactggccg gtctcgctca gtgctatcag caacgacccc agcacctcag ctcgatgcgt
     8341 gctgtcggct tccccggcca gcaaggcgtt ggcgcgctcc agcagcttga ccgccgatcc
     8401 catcgccccc tcgtcgaagg accgtcgccc ggccgtcgcg aagagccggc cggcccggcc
     8461 cttgtcccca ccggtctcgg cgagctcggc caccatcggg caccactcac ccggcagccc
     8521 ggggtgcagc tcctcgatcg cgtccgcaca gcgtctcgcg agtgtggccc gctcggtcgg
     8581 cgtcagcccg gcaagcaacg cgtcagcggt cagcggatgc cggaacgcgt accagtccgg
     8641 caccggctcg tcgggcccca ccagctgcgc agcaagcccg gcccgcagtg tggccagcag
     8701 caaccgttcg tcagtcccag tcgccttccg tacgacgctc agcgggaacc ggtgcccgat
     8761 cacagccgcc aacacgagca ggtcacgtga ctgtggcccc agctggtcag tccggctact
     8821 gatgctgcgt acgacggctg cgggcacacc ggtctgcaga ccgtcgacga cctgaacact
     8881 gccgtcaggc ttggacagca gctgccctga ccgcgtggcc tcttgcagca attcctcaac
     8941 aataaaaggg actccggcgc tgtcctgcca cagcctgtcg accagatggt cgggtacgcc
     9001 gctcaccggg acttcgagac agccggaagc gagctcacca acctcggccc ggtccagcgg
     9061 ctgcagctcg atcagcgcag ccgagccacg ctgtgcggac agtctggcga gttcaagcgc
     9121 cgcacacgtc tccgaccgca gcgtcgcgac cagcgtgatc ggctgctcgt ccaggttgtc
     9181 gagcaggtac tcgatgacgg ccagcgtctc ggggtcggac ccgtgcagat cctccagcac
     9241 cagcaggcat ccacggtcct tgccgaccag tgccagcaac cgcagtacgg cctcacccag
     9301 tacgacggcc gacgtcgccg tgtcatgcgc cgtaccgtcg tcccagtcgg ggaccaggcg
     9361 cccgagcacc tgccggtaag gaccgaggcc gtcggcggcg ggcatctcgc cccggcggat
     9421 cagcgacagc agagcctcgg tgaacgggcg gaacgcgacc atggtgccga tggctccgac
     9481 ccggccgcgc agggtcgcca tgccgctgtc gatcgcccgg gtggtggcga cgccggccag
     9541 ccggctctta ccgattccgg gctcgccgac caggaagacc gcacctccgt gaccgcctgc
     9601 ggccgaggcc agcaggcggt ggagatgatc gatctcccgg tctctgccga ccactctggg
     9661 cgcacgggtc tgcatgcttg ccaactttaa cgacgtctgg cttataccgc agcgaatcgg
     9721 cggggcctcc cggccacccc ccagtggacc ggacgacccc gccgatcaaa cgtttgccgg
     9781 gccggtcagg actcgatcgt cggccaggtg ctgctgtaat cggtggctgc gaccgcgatg
     9841 gcgaacgcgc tcatcccgac ggtgccgacc agggccatcg cccgggcgcc gaccttgttg
     9901 cgcttcggca gcgtgatcgg gccgatcggg tcgatgccgt cggtctgcgg ctcggcgtcg
     9961 tacttgccat cctggtcctg cgcagtgtgg tgctgggcgg tcattgctgt ctcccctgtg
    10021 tcgtgtgggc cgacctcttc ggcccgctgg ttggttcgag cagcaggacg gacggaacgc
    10081 gttcggagaa cgccagccgg agcaggccgt agccgattcc cgccaggccg gtcagcaagc
    10141 ctggagacgg aaccgcccgc ggtgtaccgc actgtggtcc gtactgctgt actgctgcga
    10201 gcaccagccc ggcccggcgt ctccggaccc cctccacggc tgcgtgatcg cgtgcggcga
    10261 gccacacgat tggctccacc gcgccgagct cgccatgaca cagactcaag tcggcaagca
    10321 ccggtcgttc ggttgcggcc ctcaggtagg cgtcgaggtc cgcgggtact ccggcgctca
    10381 gccgggccag agcggtcccg gcatcaccag agcaccaacc gtgtccacca gggcggacac
    10441 gtcgatccag atcggccgcc gttctcgcgg cgtccgcgta cttgtcacca ggtacgccgt
    10501 actggccgag ggcccaggcg atcccttggt aacctcgggc gaagccggag gccgctgcta
    10561 ctcggccccg gcgtacgccg agttccacgg tgttgaccaa ctcgtcggcg tagcgctttg
    10621 ctagccgagt ggccgacggc agcccgtgga tcgattgcat ggcggtgagt ccgccggcgg
    10681 ctccctcggc gtacgtcggg aactcggtgg gctcgggctt gagctgctca gtgagttcga
    10741 gcgctgccgc gagccagttg gtgagttctg cgtcgccgag tagtgagcag agacggttga
    10801 ggccgtagct gatgccgccc agtccgtgca ggccagggcc gaccagttgc gcggactcca
    10861 ggtctgcagc caggttctcc aacagagtgg ggatcgggcg gatcgcgtca cgtgccagct
    10921 cgcagtactt gtgcgctccg gtcaggacac cgacctgtgc gaggaagagc gccgtaccgg
    10981 tgtagccgtg ggaaagccct gcacccattg gccttacggc ccaatggtgg tcgtcgagta
    11041 gctccagtcc gagccagttc gccgggccgc cgtgctcgct gagcacctgc gccatgatct
    11101 cgtcggcgat gtccgtggca gcggccagta gctgctccgg gtccgcctcg gtggcaccga
    11161 cgtccggccg gctcgcagtg gcggcgtgca ctactggctc cggccgggtg gcgagtgacg
    11221 ctgagatcag ccacttctgc cggtgctcgt cgatgtcgct gagctgttgg accttggctt
    11281 cgacagtcgt gaggccttcg gtggtgagca cgttggggat gcgagtgccg tcggatgccc
    11341 acacgtcccg gctgtccggc cgagtggtga agagcggtac gtcgcctgcc cacaggtcag
    11401 cgagctcata cggcacgatg gcgtgcagtg actcgtctgc gtcccacaac aggtcgagaa
    11461 gctggctgcg accggctgcg tcccggagtg cgtccgggtg cgtcgcctcg tccaagagcg
    11521 ttgtgtagag gttcgtactg cgggggacga agcggatctc gtcctgcgcg cagcaccgca
    11581 gcagaccgat gagctcgtcc cggtgccaga caatcgcctc atacgcggcc cggaaccctg
    11641 tgagcacagc gatttcgtgg tctcgcggtt ccatgtacac gccgtcgagc agtggccggt
    11701 tgccggcgcc tttcgtcttg cccggacgtc gtactaggtg catggagtcc aggcccgcgt
    11761 cggcccagtc gaccacgctg gatggtgctg tcgcgtcggc gtcgccacct agcccggaga
    11821 ggtcgaccac gccgtgttca ccactcacaa gcagtggcag gagtgcggtg cggtagaccg
    11881 agctgagaag agagcggtac gccggatcac ggctgagcgt tcctacgagg ttgtggctcg
    11941 ggtggaacag cgtctcgatg tccacgagga ccggctggtc tccgaccgcg atcaggttct
    12001 cgtagtgcat gtccgtgccg tccagcacgt acagcagtgc cagcaaagcg ccttgccggt
    12061 ggtagaaccg gcgtacgtcg ctcaggtcgt tgcacggccg atgtacgacg tactccagcc
    12121 agccgtagcc aggccggggg agcaggtcga ccgtgctgat gtccaagccg gtcttggtgt
    12181 tgagccagtc gaccagctcg ttgaagtgct ggtgcaggtc gagcggccgg ggcttgtaga
    12241 ccagccgccg cccgtcggcg aaggtgaggg ttgccgtgga ccgcccgccc cggtggggat
    12301 cgcccccggg gtcgatcgcg gtcaatgcgc caggatcacg gccgccgagc agtccggcga
    12361 cgagcgactc acggtcctcg gcgagtcgtg ccagcagttc gaggtgaccc tcgacgcctt
    12421 gccggcacga ctcgcccagg acccgggcca gcaccgggta tgcggccagg aactccgcca
    12481 gctcgctccc tccaacgagc cggtgggtga agtccagaaa acgttcggcc ggggtgtcac
    12541 cggccagcgc gccacggtcg cgggcacggg cgagctccag caccagcgtg cgcgacgcca
    12601 gcttcaccag ccgcagcccc aacctgtgca ggaactgctc agccagtacg ccggggtgcc
    12661 cggcagcagc caggtcgcgg cgagctgagg cgagcagcgg ctcgaggcac cgcataagcg
    12721 cctgccgcca gtcgctgtgc ccacccgatg ctccgtcagc cccacctgat gtgtggttgg
    12781 cggtagctac ggtccctgca gggctgcgac cggcggcaga cgcggtctgg atggtggagg
    12841 tactgcgctc cacgtactcc gcccagggcg ggacggtgcg gctcacctcg tgcggacgca
    12901 taccggcgga ccaccaggct ttgcgctggt cggtccggcc tggccgggcg gtcgctgagt
    12961 tgagcactcg cacaggctgc caccggcccc ccaccccaga catgggtagc gagcccccat
    13021 atttgtcgct cagcgtgctg tgtgggcagg cgtgcacctg ccgcggggtg acgactgggg
    13081 gttgaccacc ccgcggcagc agtgcccttg ccggccggcc tttggtggaa agcaggcgcg
    13141 gctcaggatg ggagcgctac ggctcccagc tctttgtctg cactcgtctt cggcctcctc
    13201 tgtccgcgaa atctggaagg aacggccgga acgatgcctg accgatcagg ggttcggcaa
    13261 gggctccgca cccccaattt cgaggccggc gagtaccgca gacagatggg tgcaaacgga
    13321 ctggaacatg ggggccgtac acccatgtgc gaaggcgcgg acgctgccac ggttggcgag
    13381 tgctttcccc cgtcactccc ggattgcccg tctcagctca ctcggtgctc gacgtcgtac
    13441 cgcagctggc cggtcagtcg gctgcggccg cgctccggga gacggcggag gtggcacagg
    13501 ctgccgacga cctcgggtac cgccggttct gggtggggga gcaacacggc gtccgggggg
    13561 tcggtagtgc ggcaccggct gtgctggcgg cggttctggc agcacggacg gatcggatcc
    13621 ggctgggtgc gggcggggtg ctgctgacga accaccagcc actggtggtc gcagagcagt
    13681 tcgccgcgtt ggcggcggcg tacccaagtc ggatcgatct cggtgtcggc cagcagttcg
    13741 gcctggttgc cagtacggcg gccgcactcg gcgctgcggg ccgtgacacg ttcccgcagc
    13801 ggctggacga gctctgcggg ttcctgcgtg acggactgcc tgggcgtgcg ccggtcggcg
    13861 acgtacggct gtcgctggct ggtctgccgc caccagtctt cgtgctggct gatcacccgg
    13921 gcgctgccgc gattgccgcc gtacgagggt tgcctgtctt tcttgcacat cactgtgctg
    13981 cggcgacgac ggctacggct gtggcggcgt accgggatca cttcgaggcg accgggcctt
    14041 cggtgaagcc gtacctcgcg gtgacggttg gtgtggtggc cgcggactcg gaggaggagg
    14101 cgatcatccg gttcgccgaa tacgtccggg tgaagtcgcg tctggccgcc gcctcgccca
    14161 gagcgacccc gggggagctg atggagctcc tggagccgcc attgaccggt cgggagcgtg
    14221 gcaaggccga gcggttgctg gacgatcccg gacacattgt cggctctcgc gccacagtgg
    14281 tctccggcct cggcacgctg gtggccgaaa ccggagcgga cgagatcatg ctgatcccgc
    14341 tggccttcga cggcctggtc cggtcagcca tcctgcgtac gatcgcagcc ggcctgaccc
    14401 gcacagtccg taccgtcccg cgccacgctc caccactcat cgccacagcc tgagcgacgt
    14461 acctatggtg ggtacatgac gagcgagcgg gaagtcatcg aggcgtgtcc gaccgagctg
    14521 ttcatcggcg gtaagtggca agcctccgca agcgggaaga cgctggacgt cgaggaccct
    14581 gccaccggta cggcgctctg cgaagtagct gacgcgagtc cggcggacgg ggtggctgca
    14641 ctggatgcgg ccgtggccgc gcaggaggac tgggcggcgg tcgcgccccg agagcgcggt
    14701 gaggtcctcc gccgtaccta tgagttgatg accgagcggg ccgacgagct ggcgttgctg
    14761 atgacgctgg agatgggcaa gccggtcgcc gagtcgaagg ccgagatcgc ctacgccgcc
    14821 gagttcttcc gctggttcgc cgaggaggcg gtccggatcg acggcggcta ccaggtcgcg
    14881 ccgaacggca agggccgctt cctcgtgatg cggcagccgg tcgggccctg cctgctggtg
    14941 acgccgtgga acttcccggc cgcgatgggc gcccgcaaga tcggcccggc cgtcgccgcc
    15001 ggctgcacca tggtgatgaa gccggcctcg caaacgccgc tgtcgatgct gaagctggcc
    15061 gagctgatga ccgaggccgg gctgccggcc ggcgtactca acgtgatcac gaccagcgac
    15121 gccggcggcg tgatggagcc gctgatccgc gacgggcggg cccgcaagct gtccttcacc
    15181 ggctcgacgc aggtcggccg gaagctgatc gagcaggccg ccgagcaggt gctgcggacc
    15241 agcatggagc tcggcggcaa cgcgccgctg ctggtgttcg aggacgccga cctggacaag
    15301 gcggtcgacg gcgcgatgct ggccaagatg cgcaacggcg gcgaggcctg tacggcggcc
    15361 aaccggatct acgtgcagtc gtcggtgatg gacgagttcg cgacccggct gaccgagcgg
    15421 atgtcggcac tgaaagtcgg gcgcggcacc gaggacggca tcgacgtcgg cccgctgatc
    15481 gacgccaagc agcgggacaa ggtgaaggac ctcgtcgacg acgcggtcgc ccagggcgcg
    15541 cgggtgctca ccggcgcatc ggttgccgca ggcaacgggt acttctacca gccgaccgtg
    15601 ctggccgacg taccgacgag tgcccggttg cagaaggagg agatcttcgg cccggtcgcg
    15661 ccgctgaccg ccttcgagac cgaggacgaa gcggtccgga tggcgaacga caccgagttc
    15721 ggtctggtct cctacctgtt caccaacgac ctcgcccggg ccctgcgcgt ctccgaacgc
    15781 ctggagaccg gcatgatcgg cctcaaccag ggcatcgtct ccaacccggc agctcccttc
    15841 ggcggcgtca agcagtccgg cctcggccgc gaaggcggct ccgccggcat cgacgagtat
    15901 ctcgagatca agtacgtagc ggtcaacctc gactgatccg cacggccaag ccagtcatcc
    15961 tcgaccgacc tggacggcca tggtggtcag ggcgcactcg acccaggtcg tccccggtgt
    16021 gaggagcaac cgcttgccgt ccggaccggt gaaggcgaag ggatcgttca cgcctgcctt
    16081 ggtccagcgg ccggtgacga ccttgccgcc ggtgaacagc tgaagctgtc cggaggtgtc
    16141 ggtgaagtcc aggatcgaca tggacttctt ggcctgcggg aagctgtggt ccggcgccgc
    16201 gcgcaggacg agcacgttgt cggccgcgac ctggccaccg ccctcgatca tgtgtggcgc
    16261 ccactgctcg gcgcgggtcc agcgtttggt cttcgcctga tacgtccagg tcgccgtcga
    16321 cgaaccgccg tacccgatcc gcaccgaggt cgccggggtg ccgagacggg cgctcgactc
    16381 ggcgatgccg ggggcgtaac tgaagtacgg cgccggcgcg gtccgcttgg tcagcgtgag
    16441 cagtttcgcg ggttgggcga agacgtggtt cggcgcgcgg cggcgtgagt cgatccggta
    16501 ggtgtcgggt gggacgacca aggtgccgcg gtcgtcgaca tcggtgacct tttcgaagta
    16561 cgtgagtacc cagcggtcgg ccatggtgtc ggcgacgatg ccgcgggtgg gaccgagcag
    16621 ggcggcgtcc gtcgggcgca gcgaccggac cgggccgatc tgagccggca gcttcgattg
    16681 gaagatggcc gcgagtcgcg tggtcgatcc ggtgatcggc tcgacgaaga cgagatccgc
    16741 gtcgccgaga cctcgctgcg ggtgggcgtc ggtcgtattg gagatcttga ccgccagcgc
    16801 gggccgcgtc ggcacctctt tgaccggtac gccggtcagc ggcgcacggc cggccatcga
    16861 gacggcgccg tcgctcggtg gggtggtcga gaccggagcc ggcgactcgc tgggagtgtt
    16921 ggcgttgagc tggctgcacc cgctgagaat cagcaaagtc accaaccccg cgagcgtcct
    16981 tctcactctt ccaagatcgc tcatcttgcc ctctcgcgcc aattcaaccc ctcatcagct
    17041 cggtgatggt gacgagctga tacccgcgcg cccgcagcgt cttcacgatc ggcccgatcg
    17101 cctcggccgt gtacggcgcg ttgtcgccgc catgcatgtg cagaaccacg atcgacccgt
    17161 tccgcacgtt cgacagcacc tgcttgacga tcggttccgg tcccttcgcg aagccgtcgg
    17221 ccccgggcac atccaggccc acagcggtca ctccggccgg cgccagctcg tgcagcgcgg
    17281 tcccgtcgta acagccgcct gggaaccgga accagcgagt ggggtgcgga tcgagccgat
    17341 ccagcagtac gacggcacgc cgtacgtcgg acagcatgtc ggcgcgcgga acagtgccga
    17401 gggtgtagca gtgcttggtg aaaccacggt ggtcgtaggt atgcgtgcca agctcgaaca
    17461 gcggatccgc ggccagctga cgcgtgacgt ccgggtactg ctccatccac atcccggtca
    17521 ggaacagggt cgccggaacg tgcatcgccc gcagctcgtc gatcagcttc tcgttgtagt
    17581 aggacttgac cttcccactc accaaccgct tccgcatcag cgccgtcagg tcagcatcaa
    17641 aagtcaacgc cacccgcggc ttgtcccgag gcccgtgctg caccaacggc atgagctgag
    17701 ctctgggggt cgcggtggcc ggcgtactgg cgctgccggt agtcggcgta tccgcactcg
    17761 cgctgggcgg cgtactggcg ctcacggttg gcggcgtact ggcgctcacc actccggtcg
    17821 aagactctgt gtcagcacac ccactgagca gcaccaccac ggccaccgcc gcgcacttcc
    17881 cacgtcgaag acgcacaatc gcccagtatg ccccgccaac ggatcatctg accctcaccc
    17941 cggccaggat cgattcccgt gaccatcacc accgacttct gggccaccac cgcccagatc
    18001 atccccgccc tcctgctcgc catcgcggtc tgggatcagt cgttcggcga aagggacgac
    18061 tctcctcggt cttatgacat cgccggggag tgggtccggc tcttccacat cctctccatc
    18121 gggctcggtg tgctggggga gttcgtcgca ctgaacggcc tgctggacgg cggtagccga
    18181 tgggcagcgc ggttggtcgt tctcgcgatc gggctgctgt cccaggtcct cgtcggtctg
    18241 ctcacgatca ggatctacaa ccgcaaccgc aacaccgaag cgatggatca gtcatgtctc
    18301 agattgcttc acagcctcgt ggtagcactg atgtgcttgg ccgccacgct ctcatcgttg
    18361 atcgccgcta tctggctcgc gatccggatc tgatcagttc accaggtcgt tggccgaacg
    18421 taggactgga atgccgacgc ttgtcggcgc ggtgccgccg gtgacgtgga aggtgtggga
    18481 ctcgccggcg gacaacgtga ccaggccgga gtcgactcgg gcagcgggat ccaggcggtc
    18541 cgggaagagc gccagatcct tcgccagtgc tgacgctgtg accgtgacgt cgtacccgtc
    18601 gtccgtcttg gtgaccgacg cggcgtaggc gttgccctcc aggtgtagct ccgtgtcctc
    18661 ggcaaagtac cagtacgtcg agctgccgtc ggcgccgcgc acctcgaggt actcacgggt
    18721 cgggtcggtc ggcttggcga ctgacccggg gagtgagctg aggacggccg atcgcggcgc
    18781 gacttccagc gcgaaggtct cctgggcgat gacgtcacca ccagcgcgcg tcgaccgccg
    18841 cttcaccgtg acctcggtcg accagaggac gtccgtgtcg ttgtgggtag caacgaccag
    18901 ctcgtcctct cgtggctgca cggtgagcag gcgttcggcg tacacgcgct tcaacgcgta
    18961 ccacagcggc ttgcgaatcc cgtgaccgtc gaccgcggcc caggagacga ccggccagtt
    19021 gtcgttcagc tgccagacga tcgcacccgt gttcaacggg aacaggctcc ggaagtgctc
    19081 gatgccaaag acgatcgcgc gagcctggtt cagctgagtc gtccagtgcc agtcagccat
    19141 gtttgctgcg ttccccgccc caccgccccg gtcgttcttc cacttcggca gatgctcacc
    19201 aagaccgcgt tcgagcttga ggttgccctc gaacgccttc tggtgcacga gcatctgctc
    19261 gccgtacggg tcgagcggct cgtcgtgcac caccgaggtc agcgtcgacc aggccggcgg
    19321 cccctggaac ccgaactccg acgcgaaccg cggcttgtac ttccggtacg tcgtgtagtc
    19381 cacctggttc cacacatccc agatgtgcat ggtgccggtg cgctcgtcgt tcgggtgaat
    19441 gaagtggtcg tacgagtaag ggcttcccgg cgagtacggc gttcgcgggt cgagctcggc
    19501 cacgagcgcc gggagcaggt cgaagtagta gccctcaccc cacgcgcgac cggccagcgg
    19561 cacccgccag ccccactcga cgtagcccca gatgttctcg ttgttgccgt tccacagcgc
    19621 gaggctcgcg tgcttgctca gccgcgtgat cgcctgccgc gcctcggcct cgacctcacc
    19681 gcgcagcggc tcgtcctccg agtacgccgc acacgcgaac aggaagtcct gccacaccag
    19741 gatcccctgc tcgtcgcaga tgtcgtagaa atcgtcactc tcgtagatcc cgccacccca
    19801 gacgcgcagc aggttcatcc ccgcgtcgac cgcgtcctgg atgctcgtct cgtacgtcgt
    19861 cctgctcaac cgcgtgacga aggcgtcgtc cgggatccag ttcgcgccac gcacatagat
    19921 cggcttgccg ttcaccgaga tcacgaacgg cgaaccatgg ttgtccgggg caacgtccag
    19981 gctgacgttc cggaatccga cccggccgtg ccacgtgtcc tggccgaccg acacggtgac
    20041 gtcgtacaag ttctgctcac catggccgcg cggccaccaa acttgagcgc cttcgactgc
    20101 tgaagtgatg gtcgccgtcg aggtgccggc ggcaacggtc agttccgtcg tggttccacc
    20161 gacctcgacc gtgatcgtcg cgtcctcggt ggatccgccg gcccaggcca ggtcgacgtg
    20221 cgtattcagt acgccgcggt ccccctcgac cgaggccagc gggcgaactg aggagatcca
    20281 cacgccggac cacgactcga tccggatcgg ctgccagatg ccgaccgtgg cgacgtccgg
    20341 cccccagtcc cagccgaagt tgctggccat cttgcgcagc gcgttgtacg ggtgatggtt
    20401 cgtgtgcggc cagccaccgg cctcggcctc gatctgctca gccgaggcga ccggcccggc
    20461 gaagtcgatc accagctcgt tgcgcccggc aaccagcacg tcgccgatga ggaaccggta
    20521 cgaccggtgc tggttctgcg tcgtgccgag ctcgcggccg ttgagcgtca cggtagcgac
    20581 cgtgtcgagg ccgtcggcaa ccagttcctg aatgtcgttg ccgtccgcaa cccagtcgaa
    20641 cgacgtccgg tagctccagc tggtccggcc gatccatgcc agcttcgact cgttgtcgcc
    20701 gtcgaacgga tccgggatca ccccggccgc gagcagatcg gtgtgcacct cacccggcac
    20761 ggtggccgcg acgggcgtgc tgatgccgtc cggcaccggg ccgtcgatcg cgcgcacggt
    20821 ccaggcgacg ccgccctcag tggtcagcgg gactgtgttc acagcgactc caagttcaac
    20881 tagaccggtt aagttcgacc aagccaaagc cacggaattc cccggcggac acggtccgcc
    20941 ggggatccgg taatacagag gtcagagcgt ggccgcgttg acgtcccagt cgtccggcag
    21001 gatcgccgcg acctcgaccg tgctgttgac gtcgacgaaa gcgccggtgt cgatcgactc
    21061 ggtgatggac gccatcacgt cgacgatgtg gaacgccagc gccccggtgg cccggtgcgg
    21121 ccggttctcc cggatcgctc gcgccatgtc cagcacgccg gtgccacgct cggccgtcgc
    21181 ctcggtggtc gcgaccgtct cccagtcctc accgtcgcga cggcggatct tgatctcacc
    21241 gtcgaaccgg ttcggatccg gtacggcgag cgtcgcctcg gagccggtga tctcgacgaa
    21301 cccggcccgc ggcagcggcg agtcgaagct gaagatgctc tgcgacgact gccccgactc
    21361 gaaccgcgcg atcgcgctga cgtgggtcgg cacggtcaca tcgaagtcgg tgcccgccag
    21421 cggaccggat ccgatcgtgc gcttctcccg cgacttcgag ccaagtccgg ccaccgccgc
    21481 gaccggcccg aacagctgga ccagcgtagt caggtagtac gggccgatgt cccacagcgg
    21541 tcccgcaccc tcctggaaca ggaacgccgg attcgggtgc caggactccg ggccggggga
    21601 ctgcatcagg gtcagcgcgg tcagcggctg cccgatgtca ccccgctcga tgatccggcg
    21661 cgactcctgc agacccggac ccaggatggt gtccggcgca cagcccagcc gcagaccggc
    21721 gtcctgcgcg gtggccagca gcttcaggcc gctctcctgg tcgagcgaga acggcttctc
    21781 gctccacaca tgcttgccgg cggcaatggc ggccagagcc acctctacgt gcgcgatcgg
    21841 gatggtcagg ttgaccacga tctccacgtc cgggtggttc agcaccgcct cggggccgcc
    21901 gtgggtctcg atgccgtact gctcggcctt gtccttggcg gcttccggcc gaaggtcgcc
    21961 gatggcaacc accttcagat ccgggaagct ctgcatgctc ttgatgtacg cgtcggagat
    22021 cactccggcg ccgatgacac caactccgac agcgctcatg caggcgcacc ctctccggtc
    22081 aggaacttgt agctgccctc gaccgcgtcg aagatctcgc cgctgaagtc gtccagctcg
    22141 accacccgca gcgcgttcgg gaccgcggcc aggatgtccc ggaccgcgat gctgccgtcg
    22201 ccgaccgcca cctgggcctt gttgtccagc gtgccgtcgc cgtccttgac gtggatcgcc
    22261 ttcacccggt cgccgagctt gcccagcagg gccggtacgt cggcgccgcc gacggccgcc
    22321 cagtaggtgt ccacctcgag gatcacctcg tcggacaggt tgtcgaccag gatctcgagc
    22381 gcgtggacgc cgtccacctt cgactcgagc tcgaagtggt ggttgtggta gccgaccgtg
    22441 atgccgtggt cggcggcctc gatcgcggcc ttgttcagcg cgtcggcggt ggccttgatg
    22501 tcgtcgatcg cgttccaccg cgcggggtcg acgtacgggt cgatgacggt cgtgatgccg
    22561 agccgcttcg ccgcggcgta gatcgggccg ctctcgtcgc ggagcaggcc ggcgtgggtg
    22621 gtgggtgccg acagtccgta cttgggcagc gcctcggcca gttggtccgc gaagttggtg
    22681 acgccgaagg gctcgacctt cgtgtagccg atctc
//
