LOCUS       NZ_SLWR01000002        22541 bp    DNA     linear   CON 05-APR-2024
DEFINITION  Kribbella antiqua strain VKM Ac-2541 Ga0310564_102, whole genome
            shotgun sequence.
ACCESSION   NZ_SLWR01000002
VERSION     NZ_SLWR01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kribbella antiqua
  ORGANISM  Kribbella antiqua
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 766252)
  AUTHORS   Whitman,W.B., Woyke,T., Klenk,H.P., Zhou,Y., Lilburn,T.G.,
            Beck,B.J., De Vos,P., Vandamme,P., Eisen,J.A., Garrity,G.,
            Hugenholtz,P. and Kyrpides,N.C.
  TITLE     Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase
            III: the genomes of soil and plant-associated and newly described
            type strains
  JOURNAL   Stand Genomic Sci 10, 26 (2015)
   PUBMED   26203337
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 766252)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 185.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004345665.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 04:15:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,825
            CDSs (total)                      :: 7,760
            Genes (coding)                    :: 7,713
            CDSs (with protein)               :: 7,713
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 7 of 47
            Pseudo Genes (incomplete)         :: 41 of 47
            Pseudo Genes (internal stop)      :: 3 of 47
            Pseudo Genes (multiple problems)  :: 4 of 47
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:43:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 438994
            Orig. end                         :: 461535
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SLWR01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22541
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22541
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22541
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12541](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12541
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    153..166
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            575..1621
                     /locus_tag="EV646_RS08030"
                     /old_locus_tag="EV646_102390"
     CDS             575..1621
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020573563.1"
                     /locus_tag="EV646_RS08030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102390"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132145579.1"
                     /transl_table=11
                     /translation="MTSVNVDQLSSTDSDSAPLLETKKLTRHFRVGRGLSRKMLHAVDD
                     VDLTIGRQEIVALAGESGSGKSTIARLLAGVYKPTDGEIYYQGQALSSMRSRRDQLAYR
                     SDVPMVFQDPFSSLNPAFRVSHGILRSLKLHRTDLTRSQRYDEAERVVEAVGLAPAGEI
                     MHRYPYELSGGQRQRIGFAQALAHKPKLILADEPVSMLDVSIRIGLLNLMAELRRSEGV
                     SFLYITHDIASARYVADRLVIMYAGHIVESGPTESVLANPKHPYTDLLLGAVPDPRAPL
                     TAAVEGDTGEPPKVIDPTPGCRFRWRCPLVVDECHHITPTRRRLGDNHDAACHVAQPDP
                     GEENLAAR"
     gene            1751..2473
                     /locus_tag="EV646_RS08035"
                     /old_locus_tag="EV646_102391"
     CDS             1751..2473
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024583.4"
                     /locus_tag="EV646_RS08035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102391"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_132145581.1"
                     /transl_table=11
                     /translation="MASPRVRQILLEVLTDPPGHTSTAEQVLDRLCAALIGAIPIDGAG
                     VALMTSAGHAGLLVASDAPAAALENLQQTLGEGPCLDASREGRPVLLPDLARTGSTWSP
                     GFAASAADAGVAAIFAFPLQVGAIRLGVLDLYRRTTGALDSLELAEALDFASAATTILL
                     DLQHGAPPGELHPLLAEVADGHREIHQATGMVSVQAAVGLTEALLLIRAHAYATERSLF
                     DIAKDVVHRRLNFSSDGA"
     gene            2530..3246
                     /locus_tag="EV646_RS08040"
                     /old_locus_tag="EV646_102392"
     CDS             2530..3246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012921664.1"
                     /locus_tag="EV646_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102392"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_132145583.1"
                     /transl_table=11
                     /translation="MTREQRLGRVFVELADTLVDDFDVIDLLHLLCERSVELLDADAAG
                     LILADQRGRLQVMASTTEEARLLELFVLQNDEGPCLDCYTTGQQVANVNLDEFSHRWPR
                     FQAAATAAGYASTHALPLRLRGQVIGTLGLFCSQRSTLSEDDLDLGQALCDIATVALLH
                     ERAIRSSELLAEQLQSALNSRIVIEQAKGVLAASADIALSAAFTLMRDHARRNHLRLST
                     IATDITNGTLTAADLE"
     gene            complement(3255..4526)
                     /locus_tag="EV646_RS08045"
                     /old_locus_tag="EV646_102393"
     CDS             complement(3255..4526)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020390783.1"
                     /locus_tag="EV646_RS08045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102393"
                     /product="hypothetical protein"
                     /protein_id="WP_132145585.1"
                     /transl_table=11
                     /translation="MDEAAIAVLIVILLGAAGITWGIVALVRRQQYIKSLRDRGWIFVN
                     SPAFDAVERLGNPPFGLGFRRRPDDQIAGLTSLGRPFQVIEYSSEHWSGWVGMVTLSRR
                     LPELWITGGETQPRYGVEAVMVPSQLGPGWQVGALDPAFAAAVLTPQVCEQLNVMAAGG
                     PGVNLSIDGDQLVMLDPPRKEVELLAYWLEVLATVAAVIDDTPLDHWIQPVKPWGMTFY
                     HHPDWQWIGVDDSLLQTTPVTQSGHDHSTSEVIRGRDGDGPPFVAFTHHWKTTRTETYT
                     DSEGRSQTRTVVENHSEPILGFQLPIRMPWLQVANRGRGITFESEAFNKQFSVTAQDPK
                     FAYDVIHPRQMEYLMANPPAPFRIVDDWAWFSTGVHNQPAIAHSSHFLRGFLSRIPRFA
                     WRNLGLPDTPYPPQDRTPVPDHGE"
     gene            complement(4653..7400)
                     /locus_tag="EV646_RS08050"
                     /old_locus_tag="EV646_102394"
     CDS             complement(4653..7400)
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020573657.1"
                     /locus_tag="EV646_RS08050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102394"
                     /product="alkaline phosphatase family protein"
                     /protein_id="WP_132145587.1"
                     /transl_table=11
                     /translation="MQVTRRRLRREDKGLLSRRLGRRTTLVTAGTTAVAVAIAGTAVAS
                     THQFGTDQVGQVTDKGQVVSADQYIKPIGDRLVLQKGKIMSSTVSPDGSHLAASVTDGG
                     MALAIVDLKNWKVQQYVGNNAAADLKIPGNDIGQEGPTYSPDGKQLWLGQSDGYRRFTV
                     NPDGSLANPTFVTIAADGTKHALVGEAVFSPDSSTVYSAVNGQNRVVAIDTATGTIKQS
                     WAVGNAPRDLAMVGNKLYVSNEGGRPAKPGDPTINSYGTQVVASQVTAATTTGTVSVID
                     LSNPAAAPASIDVGLHPTALYAKNGALFVTNVATNNVSVIDTKRDKVVQTIATQPWPEA
                     SVGYEPDGVTLTDDGHLLVSLGRANAVAVYKYKNPLEPVSYVGLLPTDYFPAELAQVGN
                     QIVVSNTRGVDARRTTTAAGHGTHDTTSSLTRFTLPNDQSIHGLTAQVFQQNGWTPGSA
                     QVTSGKGAQPVPVPLRLGDPSTIKHVFLIVKENRTYDQVYGDIPEGNGDPALTQYGENV
                     TPNQHAMAKQFGLYDNTYDIGTNSAEGHNWLMQADNPEYTESSAGEYTRSYDTEDDALG
                     HQKSGFIWTGAQAAGKTVKDYGEFQSFEQKPAGATWQNLYCDTKNMVATGQDTAYPIKT
                     GSAIPSLNAVSVPGFPLFDTSVPDIYKAQIWKKDFAKFGPANFNMFWLSNDHTGGPPNG
                     AAQVADNDLATGQIVDEISHSKYWKDSAIFVVEDDSQAGLDHVDGHRAPIQIISPYAQH
                     GVVDNHYYTQITMIRTIEQILGIKPMNQKDTAATPMFGAFTQRPDFTPFKSVPNRTSLT
                     AGLSTVPTCGADVPAAQNPNAAPAPKATVPADQQAMAAQWEAWKAQQRTTGPNAKADFA
                     NPAQMNHFDWYQAHDWTTPYPGEAKILAPNDVPGAVIPSAENDG"
     misc_feature    complement(7341..7343)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7405..8751)
                     /locus_tag="EV646_RS08055"
                     /old_locus_tag="EV646_102395"
     CDS             complement(7405..8751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081978.1"
                     /locus_tag="EV646_RS08055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102395"
                     /product="ABC transporter permease"
                     /protein_id="WP_132145589.1"
                     /transl_table=11
                     /translation="MTAIVAPAVARRVSVARGYRFELVKLVSQWRIRVIVVACWLAPAA
                     FVAVVSQQSSLPADTLFGRWMHATGWAGALVMLGFAGMWALPLLTSLVAGDVFAAEDRL
                     GTWRHLLVAVRSPRRIFVSKALASLTVILLLVAGLALSSAVGGLVAVGNQPLIGLDGHL
                     LTGGDAAGKVLLAWLCALAPTLALAAIGLLGSVVLGRSPIGLLLPALVALAMQLAQQLP
                     LPVAVRLALPGYAFIAWNGLFTSPAQLGPLLIGIAVSLVWAALATTLAYLLFVRRDFTN
                     STSDGSGRRAITAGLLPLVVLFGITIAAVTPAIGSDAGITQTKVQQSLAIEFAHLYRLQ
                     TKQLNRPDVTEAQLNTTAECTKGGGQDATVGPGNDWRCVVTWHLPDVAAAGTAIYQLDV
                     SADGRYSADGDGPKEVNGYFQVRTPTGDAPNPLWQFDGNVELLSASPKG"
     gene            complement(8748..9671)
                     /locus_tag="EV646_RS08060"
                     /old_locus_tag="EV646_102396"
     CDS             complement(8748..9671)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015071999.1"
                     /locus_tag="EV646_RS08060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102396"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132145591.1"
                     /transl_table=11
                     /translation="MDRPLAVRARGITKSFGEVIALDGIDLDVADGQIHGLVGPNGAGK
                     TTLLGLLLGLAVADSGGLEILGTPVGRALSVPDGVAGFVDGPGLYPSLTARQNLAALLA
                     LRGEPTTGIGDALDQVGLTDVADDRVRGFSLGMRQRLGLAAALLTKPRLLVLDEPSNGL
                     DPAGKKHVYGVLNRLVADGTSVVLSSHRMDDVEALCSEVTILATGRVVFSGPLSKLAAE
                     NGELDYRLLTSDPETTRRLAGETDGIHIVDGIAAELLVVRGLVSALDELVVRVVQAGIA
                     VRELAPVVSPLEAAFLALTEQQELNQ"
     misc_feature    9750..9766
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.09"
                     /tool="antismash"
     gene            10001..12541
                     /gene="lanKC"
                     /locus_tag="EV646_RS08065"
                     /old_locus_tag="EV646_102397"
     CDS             10001..12541
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924048.1"
                     /locus_tag="EV646_RS08065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102397"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_132145592.1"
                     /sec_met_domain="micKC (E-value: 1e-240, bitscore: 796.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 5.6e-18, bitscore: 60.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 9.4e-08, bitscore: 27.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQYELYCLADRQFYDTPANRGIEDADFALCSRPVPDGWEHDAGE
                     IWMHYAPHNPGLPLQGWKIHVSSCLGDAERALAAVWDYCVPRGLAFKVLRSESVAIMMN
                     SKAAFRGSSGKLVTIYPPDEDHLELILKELGEILDGVSGPYILSDLRYGEGPLFVRYGA
                     FAPQYCLSNTGERVLALADSDGRLVPDVRGPVFSTPAWVQLPSFLEPHLAARNAVTTNE
                     LDYAIESVIQFSNGGGVYLGHHRETNERVVLKEGRPFAGLDEARRDAVARMQHERDILD
                     RLAGLDVVPEVRDYFVLGGHHFLVQEFIDASPLQRLVVGRYPLTRPEPSSDALGSYTDW
                     ALEMHAKVEAAVRALHERGVVFGDLHPDNILIDATDRLVLIDFEVATLAEQRARSVLAH
                     PGYVAPAGRQGVDVDLYALACLCLGLFAPQTTMLLQLCPEKVHHLGQLITETFPVPKAT
                     ISKAVGTIAGDKAMAALPMPGRDSWEQVRAAITRAIVASATPERDDRLFPGDIAQFQPG
                     GGTSVAYGAAGVLYALHRTGAGRFPEYDDWLRKHALDPATGPGLYDGLHGVAHVLDQLG
                     YRQDALDVLDRCLTQPLESRELGLHSGLAGIGLNLQHFGLRTEATQVIDLVADRLGGVD
                     DVPEISGEGNPRAGLMFGSSGPALLFLTAYERSGDTGLLDLAETALRQDLRRCVRDEYG
                     TLQVNQGWRTLPYLEEGSAGIALVLDRYLRHRPDDELAEALVALRRVNEAGYFVQSGLF
                     MGRAGLIASAAMQAEASDSLIRGLAWHALPYGGGLAFPGNQLLRLSMDLATGSAGVLLA
                     LGAALHDQPVALPFLGPNRGGSSSEPLRDDWKEV"
     gene            12545..12679
                     /locus_tag="EV646_RS08070"
                     /old_locus_tag="EV646_102398"
     CDS             12545..12679
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="EV646_RS08070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102398"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_132145594.1"
                     /transl_table=11
                     /translation="MALLDLQGLEAPGGHGGGGGGGSTLTVLTCGSQRPSNLSVVLCH"
     CDS_motif       12545..12607
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGLEAPGGHGGGGGG"
                     /locus_tag="EV646_RS08070_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12608..12679
                     /prepeptide="core"
                     /locus_tag="EV646_RS08070_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="10.60"
                     /molecular_weight="2246.6"
                     /monoisotopic_mass="2245.2"
                     /core_sequence="GSTLTVLTCGSQRPSNLSVVLCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGLEAPGGHGGGGGG"
                     /leader_location="[12544:12607](+)"
                     /alternative_weights="2264.6"
                     /alternative_weights="2282.6"
                     /alternative_weights="2300.6"
                     /alternative_weights="2318.7"
                     /alternative_weights="2336.7"
     gene            12756..14714
                     /locus_tag="EV646_RS08075"
                     /old_locus_tag="EV646_102399"
     CDS             12756..14714
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391577.1"
                     /locus_tag="EV646_RS08075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102399"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_132145596.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 4.5e-55, bitscore:
                     181.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRLGIRYPEATRQPVVDRLHGHAVADPYRWLENAVDPQTLSWQA
                     AQDRLWLNHAAELPGRYRLRARVAEFSGVGVVSPPMWRGGRQFYLRRTAHQDHPILYAG
                     DQALIDPMQLDPTGGTTLDAWQPSPDGRRLAFQLSRGGTEESILYVMDADTGQVLDGPI
                     DRCRYSPVAWLPDGQSFYFVRSRQVRLHRVGQADDVPLLTDEASYGLEISADGRWLTIS
                     AAHGSANDLWLAEVSDHPRLTVVQQGVDARSAAIVGRDGRLYVVTTLGAPAGRICIGDR
                     PGQWETLIPEDPEAPLSEIAFLDGLLLVARTRHALGEIAVHDLQTGKKVGEVPLPGLGS
                     IGSLTARPEGGHEAWFSYTDSLTPATVYRYDARTGKTTVWAKPPGTIDVPKATARQVVY
                     RSADGTPVRMLVVAKPGRHGPRPTILYGYGGFGQPLTPTYSSFTLAWVEAGGVFVTTNL
                     RGGGEEGEDWHRAGRLHNKQNVFDDFIAAAETLIADGWTTPEQLGICGESNGGLLVGAV
                     LTQRPELFAAAVCSAPVLDMVRYQRFGLGESWVPEYGSSDDPNQLASLLAYSPYHQVAE
                     GIDYPAVLFTVFGGDTRVDPMHARKMCAALQHATAGSRPILLRLEQDTGHGVAAVSRGV
                     GLTADMLAFLGAHTGLT"
     gene            14714..16366
                     /locus_tag="EV646_RS08080"
                     /old_locus_tag="EV646_102400"
     CDS             14714..16366
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391576.1"
                     /locus_tag="EV646_RS08080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102400"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132145598.1"
                     /transl_table=11
                     /translation="MTSFGAVVRHGRGWLPLIGLAALLDSAVTLALPTVLGRSVDAIAS
                     GNDLTRWLWLASGLIMLGITCALVDSFAGTACVAGTTAWLRHRLVRQVVAAGPEGTRRF
                     DTGDLVSRVSGSASDAAQAGPASVTAVAAALPPLGSLVLLALIDPWLAVGFLGGVVLVI
                     AVLWVFARRTTEISLAYQETQGRIAALLTEALGGIRTIAAAGTADREERRVLGLLPELH
                     RHGLLTWRVLARSGAQAALIGPLVLVAVLAIGGLQLVDGRITAGELFAAAQYAVIGAGL
                     GSLTGILGELARARAGIHRSAEVMAVEPVAYGSLPLPPGPGRLVYDDVSVSADDVLLLD
                     HVNLDLPGGATIAVVGPSGAGKSVLAALAARLRDPDSGLVLLDGVPLKAVRRASLRQAV
                     GCAFERPVLVGRTVSESISAGQVTPVQLLAAARATHAHDFASRLPQGYHTPLPEAPMSG
                     GEAQRLGLARAWHAGRLLVLDDATSSLDTATERQISRTLTEDRHHRTRLIVTHRASTAA
                     RADLVVWLDRGRVRAVGPHQRLWQDPSYREIFG"
     gene            16363..18054
                     /locus_tag="EV646_RS08085"
                     /old_locus_tag="EV646_102401"
     CDS             16363..18054
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924052.1"
                     /locus_tag="EV646_RS08085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102401"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_132145600.1"
                     /transl_table=11
                     /translation="MRRELGFGAAALRRRSTLEFAAWSVPEILPTAVYGLAVAHATDAF
                     LAGRAGTGLAWLGGLVAAAGVGAVGARQAYRRLGELVEPFRDVLVRRVVNGALRNNAAG
                     AVSRLNRQVEIVRDTFAGLIVVTRSFAITVVGVVTGLLSLDPVIAALVVPPFLLGFAVS
                     LGILGVAADRVKASLFADEQLTTSAGSAFAGVRDITATGAEDFAAELVGEPIEAHAAAE
                     RALARVAALRTLCFAIGGWLPLLILLAAGPWLIGRGVSTGTLLGGLTYVLLGLQPTLST
                     VMSALGDSGLRYVVTLGRILDSSAVAETPKSTGSPRGHQVRLHKVSFAYGPQAEPVLHD
                     LDLVVPEGDHLTVVGPSGIGKSTLAALICGMLPPTGGRLVVGRVPPSELSAAELAKTRV
                     LIPQEAYVFSGTVLENLMYLAPAATTNQVNRAIEVVGAEALVSRLGGPAAAIRPSQLSA
                     GERQLIALVRSYLSPAPLAVLDEATCHLDPEAERQAEEAFAARGGTLIVVAHRISSALR
                     AHRILVLDGNQAMVARHNTLLRQSPLYQDLLGHWQAPQPDQIQPAS"
     gene            complement(18033..18635)
                     /locus_tag="EV646_RS08090"
                     /old_locus_tag="EV646_102402"
     CDS             complement(18033..18635)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924053.1"
                     /locus_tag="EV646_RS08090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102402"
                     /product="response regulator transcription factor"
                     /protein_id="WP_132145602.1"
                     /transl_table=11
                     /translation="MIRVVLGHHGALVRGALAAVLSQEADLDVLAEVERADDVLPAVAR
                     TRPHVVVLDPMLDGDIRIEELCLQLREPGILILIDRDLLNGVSLALVRLAPRVGFIATD
                     ASPADLAEAVRQLAQGAAVMDAAVAVAALRATENPLTDREAEVLRLVTTGATAQEIARK
                     LNLTPGTVRNYLSHILTKTSARSRIEAVRKAQEAGWI"
     misc_feature    complement(18670..18685)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            complement(18780..19202)
                     /locus_tag="EV646_RS08095"
                     /old_locus_tag="EV646_102403"
     CDS             complement(18780..19202)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020390794.1"
                     /locus_tag="EV646_RS08095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102403"
                     /product="hypothetical protein"
                     /protein_id="WP_132145604.1"
                     /transl_table=11
                     /translation="MENEPSWREKRREAAAAQAAALEQRKAGETAKARELLAEFVQEMK
                     ARGIEPQPLRATVAGSGASYRTNVTGWYLRRNRTLGADADGNFYILAVPATLKARLLGV
                     QLLPSDPPLIVGLGARDGESMPLKDLLRLRLDETTA"
     gene            complement(19353..21086)
                     /locus_tag="EV646_RS08100"
                     /old_locus_tag="EV646_102404"
     CDS             complement(19353..21086)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391276.1"
                     /locus_tag="EV646_RS08100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102404"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_132145606.1"
                     /sec_met_domain="DAO (E-value: 1.3e-10, bitscore: 36.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVTEQQIATSVLVIGTGGAGLRAAIELAEQGVEVLVLGKRPRAD
                     AHTSLAAGGINAALATMDPDDTWQQHAADTLQESYLLANPVTVRIVTEGAARGIADLER
                     YGMPFAREADGRISQRFFGAHTYRRTAFAGDYTGLEIQRTLVNRAVQLGVPILDTVYVT
                     RILVRDNAVFGAYGFDLTTGRRYVIHADAVILAAGGHTRIWRRTSSRRDENTGDSFRLA
                     VLAGGRIRDPEMVQFHPSGLIEPENAAGTLVSEAARGEGGQLRNALGERFMTRYDADRM
                     ELSTRDRVALAEYTEIMEGRGTPNGGVWLDVSHLPRETIMRRLPRVYQTLLELQMLDIT
                     KLPIEIAPTAHYSMGGVWVRPEDHGTDVDGLYAIGEAASGLHGANRLGGNSLIELLVFG
                     RIVAEEAAKYSIDRQSQHRSADAVAEARTEVDALLASDGQENVRALQRAIRDTMTARAG
                     VVRDEAGLLAGLSELAEIEDRMTRIGVHPDIAGFQDLAHAFDLKSSALAARATLDAALE
                     RRETRGCHNRSDFPDLDESLQVNLVWSGPGQVLREAIPPIPEEFRKLMRDDISTEGKLV
                     E"
     misc_feature    21146..21161
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.36"
                     /tool="antismash"
     gene            21252..21851
                     /locus_tag="EV646_RS08105"
                     /old_locus_tag="EV646_102405"
     CDS             21252..21851
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="EV646_RS08105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV646_102405"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_132145608.1"
                     /transl_table=11
                     /translation="MSTSDFLRVRPRLFGIAYRIVGNVQEAEDVVQEVWLRWQRTDRAS
                     VVDPAAFLATITSRLAINVVQSARRRHETYVASWPREESTPGGVDPQERAEQQESIDHV
                     VRLLLERLSPAERATYVLREGFEYPYLRIAETLRIGAPTARQLVKRARDRLSSDRCSPY
                     SPAAHSRLLGALTSAARAGELTGLEEVLTAGLAEAN"
ORIGIN
        1 tcgacccgat ccatctcaag agctacccgc accagctcag cggcgggatg cggcagcgcg
       61 ccatgatcgc gatggccctg ctgttcacgc cggacctcat catcatggac gagccgacgt
      121 cggcgctcga tgtggtggcg caacggtcgc tgatggtgca gatcaaggac ctgcagcaga
      181 agctcggctt cgcggtcgtc ttcgtcaccc atgacatgtc cctggtcagc cacttctccg
      241 accggctcgt ggtgatgtac gccggtcagg tcgtcgaact cggcgccacc cgagccgtgt
      301 tcgacaatcc ggcccatccg tacagcaagg gtctgctcga cgcgttcccg tcgatccgcg
      361 gcccgaaggt gccgctgacc gggattccgg ggagcccgcc gaacctcgcc catcctccga
      421 gcggctgccg cttccatccc cgctgcccag tggccttcga agactgcccc aagatcgagc
      481 ccgagctcta ccaggtcggc tccgtccagg cccgctgcct actgcacgca cccggccaga
      541 cccacgcggc cgaccccatc cgggaggcaa cctcatgacc tcggtgaacg tcgaccagct
      601 cagctcgacc gactcggact ctgcgccgct cctcgagacg aagaagctca ctcgtcactt
      661 ccgggtcggc cgcgggcttt cccgcaagat gctgcacgcg gtcgacgacg tcgatctcac
      721 catcggccgg caggagattg tcgctctggc gggagaaagc ggcagcggca agagcaccat
      781 cgcccggctg ctcgcgggcg tctacaagcc gacggacggc gagatctact accaaggcca
      841 ggccctgtcg agcatgcgct cgcgccgaga ccagctggcc taccgcagcg acgtaccgat
      901 ggtgttccag gatccgttca gctccctcaa tcccgccttc cgcgtctcgc acggaatcct
      961 gcgcagcctc aaactgcacc gcaccgacct gacgcgttcc cagcggtacg acgaagccga
     1021 gcgcgtcgtc gaggcggtcg gactggcccc ggccggcgag atcatgcacc gctaccccta
     1081 cgagctcagt ggtggccaac ggcaacggat cgggttcgcc caggccttgg cgcacaagcc
     1141 caagctgatc ctggccgacg aaccggtctc gatgctcgac gtgtcgatcc gcatcggcct
     1201 gctcaacctg atggcggagc tgcgccggtc ggaaggtgtg tccttcctct acatcaccca
     1261 cgacatcgcc agcgcccggt acgtcgccga ccgcctcgtc atcatgtacg ccggtcacat
     1321 cgtcgagtcc ggcccgaccg agtccgtact ggcgaatccc aagcacccct acaccgacct
     1381 gctcctcggc gcggtgcccg atccacgagc tccgctcact gccgccgtcg agggcgacac
     1441 cggcgaacca ccgaaggtca tcgacccgac tcccgggtgc cgcttccgct ggcgttgccc
     1501 cctggtggtc gacgagtgcc accacatcac ccccacccgc cgccgcctcg gcgacaacca
     1561 cgacgcagcc tgtcacgtgg cgcaaccgga ccccggcgaa gagaacctcg cggcgaggta
     1621 ggccatggca ccccggtgcg tccggtggac atcgctccgt ccagcaggca ggctgaaaca
     1681 gtgacgtcat gaccgggcct gccggtcggg tgagcaaggc gcacgcagga ggttcgaggt
     1741 gagctgatcc gtggcatcac cccgagtgcg ccagatcctc ctcgaggtcc tcaccgaccc
     1801 tcctggccac acgagcaccg ccgagcaggt gctggatcgg ctgtgcgcag cgctgatcgg
     1861 cgcaattcca atcgacggtg caggcgtggc gttgatgacc tcggcgggcc acgcaggtct
     1921 gctggtcgcc agcgatgcgc cggcagccgc gctggagaac ctgcagcaaa ccctcggcga
     1981 aggcccctgt ctggacgcat cacgagaggg caggccggtc ctgctgccag atctggcccg
     2041 gaccggttcg acatggtcgc cgggcttcgc cgcgtcggcg gccgacgccg gcgtcgcagc
     2101 gatcttcgcg tttccgctcc aggtgggcgc gatccggctc ggtgtgctcg acctctaccg
     2161 ccgcaccacc ggagcgctgg acagcctcga gctcgccgag gcgctcgact tcgcgtccgc
     2221 cgccaccacc atcctgctcg acctgcaaca tggcgccccg cccggcgagt tgcaccccct
     2281 gctcgccgag gtcgccgacg ggcaccgcga aatccatcaa gccaccggga tggtctcggt
     2341 ccaggccgcc gtcggactga ccgaggcgtt gctcctgatc cgggcccacg cctacgcgac
     2401 cgagcgatca ctgttcgaca tcgccaagga tgtcgtgcac cggcggctca acttctcctc
     2461 cgacggagca tgatgaatag gcagggcgat gcgcagaagc gaccaaccgg ccgggaaagg
     2521 aaccaggtca tgaccaggga gcaacgcctc gggcgagtct ttgtcgagct cgccgatacc
     2581 ctcgtcgacg atttcgacgt gatcgacctc ctgcacctgc tgtgtgaacg gagcgtcgaa
     2641 ctcctcgatg ccgatgccgc ggggctgatc ctggccgatc agcgcggccg attgcaggtg
     2701 atggcctcca cgaccgagga agccagactg ctcgagttgt tcgtcctgca gaacgacgaa
     2761 gggccctgtc tggactgcta caccacgggt cagcaggtgg cgaacgtcaa cctcgacgag
     2821 ttcagccatc gctggccacg gttccaggct gctgccaccg ccgcgggcta cgcgtcgacc
     2881 cacgcactac cgctccggct gcgcggacag gtgatcggca ccctcggtct cttctgctcc
     2941 cagcgctcta cgctgagcga ggacgacctc gatctcggac aggcgctgtg cgacatcgcc
     3001 accgttgccc tgctgcacga gcgcgcgatc cggtccagtg agctcctggc cgagcagctc
     3061 cagagcgccc tgaacagccg gatcgtgatc gagcaggcga agggcgtcct ggccgcgagc
     3121 gcggacatcg ccctcagcgc cgccttcacg ctgatgcgcg atcacgcccg ccgcaaccac
     3181 ctgcgcctca gcacaatcgc gacagacatc accaacggca ccctcaccgc cgccgacctg
     3241 gagtaggtga ccagttattc gccgtgatcc ggcactggag ttcggtcctg gggtgggtac
     3301 ggcgtgtccg ggaggccgag gtttcgccag gcgaagcgcg ggatgcggga caggaagccg
     3361 cgcaggaagt gcgagctgtg ggcgatcgcc ggctgattgt gtacgccggt tgaaaaccag
     3421 gcccagtcgt cgacgatccg gaacggcgcg ggtgggttcg ccatcaggta ttccatctgg
     3481 cgcgggtgga tgacgtcgta cgcgaacttg gggtcctgcg cggtgacgga gaactgcttg
     3541 ttgaaggcct cgctctcgaa ggtgatcccg cggccgcggt tggcgacttg gagccacggc
     3601 atccggatcg gcagctggaa accgaggatc ggctcgctgt ggttctcgac cacggtccgg
     3661 gtctgggacc ggccttcgct gtcggtgtag gtctcggtgc gggtggtctt ccagtggtgg
     3721 gtgaaggcga caaacggcgg accgtcgcca tcgcggccgc ggatcacctc gctggtgctg
     3781 tgatcgtggc cggactgcgt caccggcgtg gtctgcagca ggctgtcgtc gacgccgatc
     3841 cactgccagt ccgggtgatg gtagaaggtc ataccccacg gcttcaccgg ctggatccag
     3901 tgatccagcg gcgtgtcgtc gatcaccgcg gccacggtgg cgagcacttc cagccagtag
     3961 gcgagaagct cgacctcctt gcgcggcggg tccagcatca ccagctgatc cccgtcgatg
     4021 ctcaggttca caccgggccc gcccgcggcc atcacgttca gctgctcaca cacctgcggg
     4081 gtcagcaccg ccgcggcaaa cgccgggtcg agcgcaccga cctgccagcc gggcccgagc
     4141 tgggacggca ccatcaccgc ctccacgccg taccgcggct gggtctcacc gccggtgatc
     4201 cacaactccg gaagccgtcg ggacagcgtg accatcccga cccaccccga ccagtgctcg
     4261 gagctgtact cgatcacctg gaacggcctg ccgaggctgg tcaggccggc gatctgatcg
     4321 tcgggccggc ggcggaagcc gagcccgaac ggcgggttgc cgagccgctc cacggcgtcg
     4381 aaggccgggc tgttcacgaa gatccagccg cggtcccgca acgacttgat gtactgctgc
     4441 cgtcgtacga gcgcaacgat gccccacgtg atcccagccg cgcccagcag gatgacgatc
     4501 agtacggcga tcgccgcttc gtccacgtgc gcctcctcgg tccacagctg tttccacgcc
     4561 ggacaataga cgcacagagg gcaaagcacg ttccgaagca cggaaggtcc ccggccggct
     4621 gccagggacc ttccgtggtt cggcgatcta ggtcagccgt cgttctccgc tgacgggatg
     4681 accgcaccgg gtacgtcgtt cggtgccagg atcttggcct cgccggggta cggcgtggtc
     4741 cagtcgtgcg cctggtacca gtcgaagtgg ttcatctgcg ccgggttggc gaagtcggcc
     4801 ttcgcgttcg gaccggtggt ccgctgctgg gctttccatg cctcccactg cgccgccatc
     4861 gcctgctgat ccgcgggcac cgtcgccttg ggcgccggcg cggcgttcgg gttctgcgct
     4921 gcgggcacgt ccgcgccaca ggtcggaacc gtgctcagac ccgccgtcag cgaggtccgg
     4981 ttcggcaccg acttgaacgg agtgaagtcc ggccgctgtg tgaacgcccc gaacatcggg
     5041 gtggccgcgg tgtccttctg gttcatcggc ttgatcccga ggatctgctc gatcgtgcgg
     5101 atcatcgtga tctgggtgta gtagtggttg tccaccacac cgtgctgggc gtacgggctg
     5161 atgatctgga tcggcgcccg gtggccgtcg acgtggtcga gaccggcctg ggagtcgtcc
     5221 tcgacgacga agatcgccga gtccttccag tacttgctgt gcgagatctc gtccacgatc
     5281 tggccggtgg cgaggtcgtt gtcggcgacc tgggcggcac cgttcggcgg gccaccggtg
     5341 tggtcgttcg acagccagaa catgttgaag ttggccggcc cgaacttcgc gaagtccttc
     5401 ttccagatct gggccttgta gatgtccgga acactggtgt cgaagagcgg gaagccgggc
     5461 accgagaccg cgttcagcga cgggatcgcc gaaccggtct tgatcgggta ggcggtgtcc
     5521 tgcccggtgg cgaccatgtt cttggtgtcg cagtacaggt tctgccaggt cgcaccggcc
     5581 ggcttctgct cgaacgactg gaactcgccg tagtccttga cggtcttgcc ggccgcctgg
     5641 gcaccggtcc agatgaagcc gctcttctgg tggccgagcg cgtcgtcctc ggtgtcgtag
     5701 cttcgggtgt actcaccagc ggaggactcg gtgtactccg ggttgtccgc ctgcatcagc
     5761 cagttgtgac cctcggccga gttcgtgccg atgtcgtagg tgttgtcgta cagcccgaac
     5821 tgcttggcca tcgcgtgctg gttcggcgtc acgttctcgc cgtactgcgt cagcgccggg
     5881 tcgccgttgc cctccgggat gtcgccgtac acctggtcgt aggtccggtt ctccttgacg
     5941 atcaagaaga cgtgcttgat cgtcgacggg tcaccgagcc gcagcgggac cggcaccggc
     6001 tgcgcgccct tgccggaggt cacctgggcc gagccggggg tccagccgtt ctgctggaag
     6061 acctgtgcgg tgaggccgtg gatcgactgg tcgttcggca gcgtgaaccg ggtcaggctc
     6121 gacgtcgtgt cgtgggtgcc gtgcccggcg gcggtcgtgg tccgacgggc gtcgacaccg
     6181 cgggtgttcg agacgacgat ctgattgccg acctgcgcga gctcggccgg gaagtagtcc
     6241 gtcgggagca ggccgacgta gctgaccggc tcgagcgggt tcttgtactt gtagaccgcg
     6301 accgcgttcg cgcggccgag cgacaccagc aggtggccgt cgtcggtgag cgtgacgcca
     6361 tccggctcgt atccgaccga tgcctccggc cacggctggg tggcgatggt ctggacgacc
     6421 ttgtcgcgct tggtgtcgat cacggacacg ttgttggtgg caacgttcgt gacgaacagc
     6481 gcgccgttct tggcgtacag tgcggtcggg tgcagaccga cgtcgatgct cgcgggcgcg
     6541 gccgccgggt tcgacaggtc gatcacactg actgtgccgg tcgtggtcgc cgcggtgacc
     6601 tgggaggcca ccacctgggt gccgtacgag ttgatcgtcg ggtcaccggg cttggcgggc
     6661 cggccaccct cgttgctcac gtacagcttg ttgccgacca tggccaggtc gcgcggcgcg
     6721 ttgccgacgg cccagctctg cttgatggtg ccggtcgcgg tgtcgatggc gaccacgcgg
     6781 ttctggccgt tgaccgcgga gtacacggtg gagctgtccg gcgagaagac ggcttcgccg
     6841 accagcgcgt gcttggtgcc gtccgccgcg atcgtcacga acgtcgggtt cgcgagcgag
     6901 ccatccgggt tcaccgtgaa ccggcggtag ccgtccgact ggcccagcca cagctgcttg
     6961 ccgtccggcg agtacgtcgg accctcctgg ccgatgtcgt tgcccgggat cttcaggtcc
     7021 gcggcggcgt tgttgccgac gtactgctgg accttccagt tcttcaggtc gacgatcgcc
     7081 agggccatcc cgccgtcggt caccgaggcg gccaggtggc tgccgtccgg gctgaccgtc
     7141 gacgacatga tcttgccctt ttggagaaca aggcggtcgc cgatcggctt gatgtactga
     7201 tcggcggaga cgacctggcc cttgtccgtg acctgaccga cctggtcggt cccgaactgg
     7261 tgggtcgagg cgactgcggt tcccgcgatg gccacggcga ccgcggtggt gcccgcggtg
     7321 accagcgtcg tccggcggcc taaccgccgg ctgaggaggc ctttgtcctc acgccgaaga
     7381 cggcggcgtg ttacctgcat tgagttatcc cttcggggag gcggacagca gctcgacgtt
     7441 gccgtcgaac tgccagagcg ggttcggtgc atccccggta ggggtgcgca cctggaagta
     7501 cccgttgact tccttcggac cgtcgccgtc ggcggaatac ctgccgtcgg cggagacgtc
     7561 gagctggtag atggccgtgc cggcggccgc gacatcgggc agatgccagg tcaccacgca
     7621 ccgccagtcg ttgcctgggc caacggtcgc gtcctggccg ccgcccttgg tgcactccgc
     7681 cgtcgtgttc agctgggcct cggtgacgtc gggccggttg agctgcttgg tctgcaggcg
     7741 gtagagatgc gcgaactcga tggccagcga ctgctgcacc ttcgtctgcg tgatcccggc
     7801 atcggaaccg atcgcgggcg tgacggctgc gatggtgatg ccgaacagta cgacgagtgg
     7861 cagcaaaccg gccgtgatcg cacgccggcc cgagccgtcg ctggtcgagt tcgtgaagtc
     7921 ccgccgtacg aagagcaggt aggccagggt tgttgcgagg gcggcccaca ccagactgac
     7981 cgcaataccg atgagcagcg ggccgagctg ggccgggctg gtgaacagac cgttccaggc
     8041 gatgaacgca tagcccggca gggccaggcg tacggcgacc ggaagcggca gctgttgcgc
     8101 gagctgcatc gcgagcgcga cgagcgcggg cagcagcaga ccgatcggag accgccccag
     8161 tacgacggac ccgagcaacc cgatcgcggc gagcgcaaga gttggggcga gggcacagag
     8221 ccaggcgagc aggaccttgc ccgcggcgtc accgcccgtc agcaggtgac cgtccaggcc
     8281 gatgagcggc tggttgccga cagcaacgag accgccgacg gcactggaga gggccagacc
     8341 ggctacgagc agcagaatga cggtcaggct ggccaatgcc ttcgatacga agatccggcg
     8401 gggtgaccgg accgccacca gaagatggcg ccaggtgccg agccggtctt cggcagcgaa
     8461 cacatcgccc gcgaccagcg aagtcagcag cggcagcgcc cacattccgg cgaagccgag
     8521 catcaccagt gctccggccc accccgtggc gtgcatccag cggccgaaca gcgtgtccgc
     8581 cggaagcgag ctctgctgac tcaccacggc gacgaaggcc gcgggcgcga gccagcaggc
     8641 cacgacgatc acccggatcc gccattgcga cacgagtttg accagctcga agcgatagcc
     8701 ccgcgcgact gaaacccgcc gggcgacggc tggagcgaca atggcggtca ttggttgagc
     8761 tcctgctgct cggtgagggc taggaacgcg gcttcgagtg gcgatacgac cggggcgagc
     8821 tctcgcaccg cgatgcccgc ttgcacgacc cgcaccacga gttcgtcgag cgcggacact
     8881 agcccgcgca ccacgaggag ctcagcggcg atcccgtcga cgatgtggat gccgtccgtt
     8941 tcgccggcca gtcggcgggt ggtctccggg tccgaggtga gcagccggta gtcgagttcg
     9001 ccgttctcgg ccgccagttt gctcaatggg ccggagaaga cgacgcgccc ggtcgcaagg
     9061 atcgtgacct ccgagcagag cgcctcgaca tcgtccatcc ggtggctcga gagcaccacg
     9121 gaggttccgt cggccaccag ccggttgagt acgccgtaca cgtgcttctt gccggcgggg
     9181 tcgaggccgt tggacggctc gtcgagcacc agcagccggg gcttggtaag cagcgcggcg
     9241 gcgaggccga ggcgctgccg catgccgagc gagaagcccc ggacccggtc gtcggcgaca
     9301 tcggtgagcc cgacctgatc gagcgcatcg ccgatcccgg tcgtcggctc accgcgaagg
     9361 gcgagcagcg cggcgagatt ctgcctggcg gtcaacgagg ggtagaggcc gggcccgtcg
     9421 acgaaacccg ccacgccgtc ggggacggag agcgcgcgtc cgaccggcgt accgaggatc
     9481 tcgaggccac cgctgtcggc gacggccagt cccagcaaca ggccgagcaa ggtcgtcttt
     9541 ccggcgccgt tcggcccgac caacccgtgg atctgcccgt ccgccacatc gagatcgata
     9601 ccgtcgagtg cgatcacctc gccgaacgac ttggtgatcc cacgagcccg gactgcgagc
     9661 ggtctgtcca tggtgccctt ctccgcggtg cctgacggaa aaacattaga gacgaataca
     9721 tatccagcca aggctcggag ttgaacgttc tgagaacgac aggcaaccgg gcgtgatcgc
     9781 ggtctagccc gctcctacga gttcagcaac tctgagggac cgcgcccgtc acaccggatg
     9841 acgatggtga cggcccgtcg ccagcagcgg acctgtcgtg acattcgcgt tggtacggcg
     9901 atgcgttctt cacggccgag tgatgacgcc attcactacg cggcgcgcgc atgtggtgga
     9961 cacgatgtca ccgaggcgtc tgacgaatcg gggggcggca atggagcaat acgagctcta
    10021 ctgtctcgcc gaccggcagt tctacgacac cccggcgaac cgcggcatcg aggacgcgga
    10081 cttcgccctg tgctcccggc cggtgccgga cggctgggag cacgacgccg gtgagatctg
    10141 gatgcactac gcaccccaca accccggttt gcccttgcag ggctggaaga tccacgtctc
    10201 gtcctgcctc ggagacgccg aacgcgcgct cgccgcggtg tgggactact gcgtcccgcg
    10261 cggtctcgcg ttcaaggtcc tgcgcagcga atccgtcgcg atcatgatga actccaaggc
    10321 cgccttccgc ggctcgagcg gcaagctcgt caccatctat ccgcccgacg aggaccacct
    10381 cgagctcatc ctcaaagagc tcggcgagat cctcgacggc gtcagcggtc catacatcct
    10441 cagcgacctc aggtacggcg aaggcccact cttcgtccgg tacggcgcct tcgccccgca
    10501 gtactgcctg tcgaacaccg gcgagcgggt actcgcgctc gcggactccg acggccggct
    10561 ggtcccggat gtgcgcggtc cggtcttctc gacgccggcc tgggtgcagc tcccctcgtt
    10621 cctggaaccg cacctggccg cgcgcaacgc cgtcaccacc aacgagctgg attacgcgat
    10681 cgagagcgtc atccagttct ccaacggcgg cggggtctac ctcggtcatc accgcgaaac
    10741 gaatgaacgc gttgtcctca aggaaggacg ccccttcgcg gggctcgacg aggcgcgccg
    10801 ggacgcagtc gcccgcatgc agcacgagcg ggacatcctg gaccggctgg ccggactgga
    10861 cgtcgtaccg gaggtccggg actacttcgt ccttggcggg catcacttcc tggtgcagga
    10921 gttcatcgac gccagcccac ttcagcgcct ggtggtcggg cgctacccgc tgactcggcc
    10981 ggagccgtcg tccgatgcgc tcggcagcta cacggactgg gcgctcgaga tgcacgccaa
    11041 agtcgaggcg gcggtccggg ccctgcacga gcgcggcgtc gtcttcggcg atctccaccc
    11101 ggacaacatc ctgatcgacg caacggaccg gctcgtcctg atcgacttcg aggtggccac
    11161 gctcgccgag cagcgagccc ggtcggtcct ggcgcacccg ggctatgtag cacccgccgg
    11221 ccgccagggc gtcgacgtcg acctctacgc attggcgtgc ctttgtctcg gcctcttcgc
    11281 gccgcagacg acgatgctgt tgcagctgtg ccccgagaaa gtccaccatc tcggtcagct
    11341 gatcaccgag acgttcccgg tgcccaaggc aaccatcagc aaggccgtcg gcaccatcgc
    11401 cggtgacaag gcgatggcgg cgctgccgat gcctggccgc gacagttggg agcaggtccg
    11461 cgctgcgatc acccgggcga tcgtggccag cgccacgccg gagcgcgacg accggctctt
    11521 ccccggcgac atcgctcagt tccagcccgg cggcgggacc agcgtcgcgt acggcgcggc
    11581 cggcgtactg tatgccctcc accggacggg tgccggcaga ttcccggagt acgacgactg
    11641 gctccgcaag cacgccctcg atccggcgac cgggcccggc ctgtacgacg gcttgcacgg
    11701 cgtcgcgcac gtcctcgacc aactcggcta ccggcaggac gcactcgacg tactggatcg
    11761 ttgcctgacc cagccgctcg agtcacgcga actcgggctg cactccggct tggccggcat
    11821 cggcctgaac ctgcagcact tcgggctgcg gacagaagcg actcaggtga tcgatctggt
    11881 ggccgatcgg ctcggcggcg tggacgacgt accggagatc agtggtgaag ggaatccgcg
    11941 cgccggcttg atgttcggct cgtcgggacc cgcgctgctc ttcctgacgg cgtacgagcg
    12001 gagcggggac accggcctcc tcgacctggc cgagacggcg ctgcggcagg atctgcgccg
    12061 gtgcgtccgc gacgagtacg ggacgcttca ggtcaaccag ggctggcgga ccttgcccta
    12121 tctcgaggaa ggttcggcag gcatcgcgct cgtcctcgac cgctatctgc ggcaccggcc
    12181 ggacgacgag ctcgccgagg ccttggtcgc tctccgacgc gtcaacgagg ccgggtactt
    12241 cgtccagtcc gggctgttca tgggccgcgc aggcctgatc gcctcggccg cgatgcaagc
    12301 agaagcctcc gactcgctca ttcgtggact tgcctggcac gccttgccgt acggcggtgg
    12361 actcgcattc cccggcaacc agttgctccg tctctcgatg gacctggcta ccggctcggc
    12421 cggcgtactg ctggctctgg gcgcggcgct gcacgaccag cccgtcgccc ttccgttcct
    12481 cggcccgaac cgcggcgggt cgtcgtccga acccctacga gatgactgga aggaggtgta
    12541 gaccatggca cttctcgacc ttcaagggct cgaggctccc ggcggccacg gcggtggtgg
    12601 gggtggcggt agcaccctga ccgttctcac ctgcggttcg cagcgcccaa gcaacctcag
    12661 cgtggttctt tgtcactgac aagcaggccg gttcacgtcc tgggcgggat gatggggtcc
    12721 cgctcaggac cccggccgcg ggaaggagag cctgggtgca gaggctcggc atcaggtatc
    12781 ccgaggccac ccgccagccg gtcgtcgacc ggctccacgg ccacgcggtg gctgatccgt
    12841 accgctggct ggagaacgcg gtcgatccgc agaccctgag ctggcaggcg gcacaggacc
    12901 ggctgtggct gaaccatgcc gccgaactgc ccggccgcta ccggctccgg gcccgggtcg
    12961 cggagttcag cggggtcggc gtggtgagcc cgccgatgtg gcgcggcgga cgccagttct
    13021 acctgcgccg gacggcccat caggaccatc cgattctcta cgccggcgat caggcgctca
    13081 tcgatccgat gcagctcgat ccgaccggcg gaaccacgct cgatgcctgg caaccgtcgc
    13141 cggacggccg ccggctggcc ttccagctct cgcgtggcgg caccgaggaa tccattctgt
    13201 atgtcatgga cgccgacacc ggccaggtgc tggacggtcc gatcgaccgt tgccggtact
    13261 cccctgtcgc ctggctcccc gacgggcaga gcttctactt cgtccgctcc cggcaggttc
    13321 gactgcatcg agtgggtcaa gccgacgacg taccgctgct gaccgacgag gcgtcgtacg
    13381 ggctggaaat cagtgccgac gggcgctggc tgacgatctc cgccgcgcac gggtcggcga
    13441 acgatctctg gctggccgag gtctccgatc acccgcggct gaccgttgtg caacagggag
    13501 tggacgcacg cagcgcggcg atcgtgggcc gggacgggcg tctgtacgtc gtcaccaccc
    13561 tgggggcgcc ggcgggaagg atctgcatcg gagatcggcc cggccagtgg gaaaccctga
    13621 tccccgagga tcccgaggcg ccgctgagcg agatcgcctt cctcgacgga ttgctcctgg
    13681 tggcacggac ccggcacgcg ctcggcgaga tcgccgtaca cgatctccag accggcaaga
    13741 aggtcggcga ggtgccgctg cccgggctcg gctcgatcgg gtcgctgacc gcccggcccg
    13801 agggtgggca cgaggcctgg ttcagttaca ccgacagctt gactccggca acggtctatc
    13861 ggtacgacgc ccgtaccggc aagaccacgg tgtgggcgaa gccgcccggc actatcgacg
    13921 tcccgaaggc gaccgcgcgg caggttgtct accgctcggc cgacggcacc ccggtccgga
    13981 tgctcgtcgt cgccaagccg ggccggcatg gtccgcgtcc gacgatcctc tacgggtacg
    14041 gcggattcgg gcaaccgctg accccgacgt actcctcctt caccctcgcc tgggtcgaag
    14101 ccggcggcgt gttcgtcacc acgaacctgc gcggtggcgg cgaagaaggt gaggactggc
    14161 accgggccgg acggctgcac aacaagcaga acgtcttcga cgatttcatc gccgcggccg
    14221 agacgctgat cgcggacggc tggacgacgc cggagcagct cggcatctgc ggcgaatcca
    14281 acgggggcct gctggtgggt gctgtgctca cccagcggcc ggaactgttc gccgcggccg
    14341 tctgctcggc gccggtgctg gacatggtgc gctaccagcg cttcggtctc ggcgagtcat
    14401 gggtgccgga gtacgggtcg agcgacgatc cgaatcagct cgccagtctg ctggcctact
    14461 cgccgtacca ccaggttgcc gagggcatcg actatcccgc ggtcctgttc accgtcttcg
    14521 gcggtgacac ccgggtcgat ccgatgcatg ctcggaagat gtgcgccgcg cttcagcatg
    14581 cgacggccgg atcgcggccg atcctgctcc ggctcgagca ggacactgga cacggcgtcg
    14641 cggcggtgag ccgcggcgtc ggcctgacgg cggacatgct cgccttcctg ggcgctcaca
    14701 cggggttgac gtgatgacat ccttcggcgc tgtcgttcgg cacggccgcg gctggctccc
    14761 gctcatcggg ctggcggcct tgctcgacag cgccgtcacg ctggcgttgc cgaccgtact
    14821 cggccgatcc gtggatgcta ttgcttctgg caacgacctg acccgctggc tctggctggc
    14881 ctcggggttg atcatgctcg gcatcacctg cgcgctggtt gactcgttcg ccggtacggc
    14941 gtgtgtcgcg gggacgacgg cctggttgcg ccaccggctg gttcggcaag tcgttgcggc
    15001 aggccccgaa gggacacgcc ggttcgacac gggtgatctc gtcagccggg tgtccggcag
    15061 cgcgagcgat gccgcccagg ctggtccggc ctcggtgacg gctgtcgccg cagctctccc
    15121 cccactcggg agcctggtct tgctggcgct catcgatccc tggctcgcgg tcggcttcct
    15181 cggcggagtc gtgctggtga tcgcggtgtt gtgggtgttc gcccgtcgta cgacggagat
    15241 cagcctcgcc tatcaggaga cgcagggacg gatcgccgct ctgctgaccg aggccctcgg
    15301 cgggatccgg acgatcgcgg ctgccggcac ggccgaccgg gaggaacgtc gcgtgctcgg
    15361 tctgctgccc gagctgcacc ggcacggact gctgacgtgg cgcgtcctcg cccgctccgg
    15421 cgctcaagcc gccctgatcg ggccgctcgt cctggtcgcc gtactggcga tcggcggtct
    15481 gcaactcgtc gacggccgca tcaccgcggg cgagctgttc gctgccgcac agtacgccgt
    15541 gatcggagcc ggactcggca gcctgaccgg catcctcggc gaactggccc gagcccgggc
    15601 cggcatccac cgcagcgccg aggtcatggc ggtcgaaccc gttgcctacg gctccctccc
    15661 gttgccgccc gggcctggcc ggctcgtgta cgacgacgtc agtgtgagcg cggacgacgt
    15721 actcctgctc gatcacgtca acctcgatct gccgggtggc gcgaccatcg ctgtggtcgg
    15781 gccaagcggt gctgggaagt cggtgctggc cgcgctggct gctcggctgc gtgatcccga
    15841 ctccgggctc gtgctgctcg acggcgtacc actgaaggcc gtacggcgag cttcgttgcg
    15901 ccaggctgtc ggctgtgctt ttgagcggcc cgtgctggtc ggcaggacgg tgagcgagtc
    15961 gatttcggcc gggcaggtca caccggtgca actgctggcg gccgcgcggg cgacgcatgc
    16021 gcacgacttc gccagccgac tcccccaggg ctatcacaca ccgttgcccg aggcaccgat
    16081 gtccggaggc gaggcacagc ggctcggact ggcccgggcg tggcacgccg gccggctgct
    16141 ggtgctggac gacgccactt cgagtctgga cacggccacc gagaggcaga tcagccggac
    16201 tctgactgag gaccggcacc accggacccg gctgatcgtg acgcatcggg cgtccacggc
    16261 ggcgcgggct gatctcgtgg tctggctcga tcgcggccgg gttcgtgcgg tcggaccgca
    16321 tcagcggttg tggcaggacc cgtcgtaccg ggagatcttc ggatgaggcg cgaactgggc
    16381 ttcggtgcgg cggcgctgcg gcgtcggtcg acgctggagt tcgctgcgtg gtcggtgccg
    16441 gagatcttgc ctacggccgt ttacgggctt gcggttgccc acgcgacgga tgcgttcctg
    16501 gccggccggg ctgggacggg ccttgcctgg ttgggtggtc tcgtcgcggc cgctggtgtc
    16561 ggtgcggtcg gtgctcggca ggcttaccgg cgactcggcg agttggttga accgttccgc
    16621 gacgtactgg tgcgccgggt ggtgaatggt gcgctgcgca acaatgctgc gggggccgtg
    16681 tccaggctga accggcaggt cgagatcgtc cgggacacct ttgcgggact gatcgtcgtg
    16741 acccggagct ttgccatcac cgtggtgggc gtggtgactg gtctgttgtc gctcgaccct
    16801 gtgatcgcgg cgctcgtcgt accgccgttc ctgctcggtt tcgctgtctc gctggggatt
    16861 ctcggggtgg cggccgatcg ggtgaaggcg tccttgttcg ccgatgagca gctcaccacc
    16921 tcagcgggat cggctttcgc cggggttcgc gacatcaccg cgacgggggc tgaggacttc
    16981 gccgcggagc tggtcggcga gccgatcgag gcgcatgcgg cggccgagcg cgcgctggcc
    17041 agggttgccg cgctgcgaac gctctgcttc gccatcggtg gttggctgcc attgctgatc
    17101 ctgctggccg ccggcccttg gctgatcggc cggggtgtca gcaccggaac gttgctgggc
    17161 gggctgacct acgtgttgct cggcctgcag cccacgctga gcaccgtgat gtccgccctc
    17221 ggagacagtg ggttgcggta cgtcgtcaca cttggccgca tccttgacag cagtgctgtg
    17281 gccgagacgc cgaagtccac gggatcgcct cgcggccatc aggtgcggct gcacaaggtg
    17341 tcgttcgcct atgggccgca ggcggagccg gtgctgcacg atctggatct cgtcgtaccg
    17401 gaaggcgatc acctgaccgt tgtcgggccg agcggcatcg gcaagtcgac gctcgctgct
    17461 ctgatctgcg gcatgctccc gccaaccggt ggacggttgg tcgtcgggcg cgtcccgccg
    17521 agcgagctgt ctgccgccga gttggcgaag acgcgcgtac tgattccgca ggaggcttac
    17581 gtcttctccg gcacggtgct cgagaacctg atgtatctcg cacccgccgc gacaacgaat
    17641 caggtcaacc gggcgatcga ggtggtcggc gccgaggcac ttgtctcgcg actgggcggt
    17701 ccggccgcag cgattcggcc ttctcaactg tcggcgggcg aacggcagct gatcgcgctg
    17761 gtccggtcct acctgtcgcc ggcaccgctc gccgtactgg acgaggcgac ctgccacctg
    17821 gatccagagg ccgagaggca ggccgaggag gcgtttgcgg ctcggggcgg cacgctcatc
    17881 gtggtggcgc accggatcag ttcggcgctg cgggcccacc ggatcctggt gctcgacggc
    17941 aaccaggcga tggttgcccg gcacaacacc ttgctccggc agtcgccgct gtaccaggat
    18001 cttctgggcc attggcaagc accgcaaccc gatcagatcc agccggcctc ctgagccttc
    18061 cggacggcct cgatccggct gcgggcggag gtcttggtga ggatgtgcga caggtagttg
    18121 cgcaccgttc ccggggtcag gttgagcttc cgcgcgatct cctgcgccgt cgcccccgtg
    18181 gtcaccagcc ggagcacctc ggcctcccga tcggtgagcg gattctccgt tgcccgcagt
    18241 gcagccacgg ccacggccgc atccatcacc gccgcgcctt gggcaagctg ccgcacggcc
    18301 tcggccagat cggcaggcga cgcatcggtg gcgatgaacc cgacccgcgg cgccagccga
    18361 acgagcgcca ggctgacccc attcagcaga tcccggtcga tcaggatgag gatgccgggc
    18421 tcccgcagct gcaggcacag ctcttcgatc ctgatgtccc cgtccagcat cggatcgaga
    18481 acgacgacgt gcggccgcgt cctggccacc gccgggagga cgtcgtcggc ccgttcgacc
    18541 tcggccagta cgtccagatc agcttcttgt gacagcaccg cggcaagcgc tcctcgaacc
    18601 aacgccccgt ggtgcccgag tacgactcgg atcacgctcc tgccccccag gtatcgcaag
    18661 acctcttccg tgacacccca gtcacgaaga gtaccgagaa ccccagatcg gtgacgctaa
    18721 gtgtgaatgg tccaggccgc attgtcacgc cctcgactcc gctgcggccc cgggctgagt
    18781 caggcggtgg tttcgtccag gcggaggcgg aggaggtctt tgaggggcat ggattcgccg
    18841 tcgcgggcgc cgaggccgac gatgaggggt gggtcggacg ggaggagctg gacacccagg
    18901 aggcgagcct tcagggtggc ggggacggcg aggatgtaga agttgccgtc ggcgtccgca
    18961 ccgagggtgc ggttgcggcg caggtaccag ccggtgacgt tggtccggta gctcgccccg
    19021 gatccagcga ccgtcgcccg aagcggctgg ggctcgatgc cgcgggcctt catctcctgg
    19081 acgaactccg ccaacagctc gcgggccttg gcggtctcgc ctgccttgcg ctgttcaagc
    19141 gcggctgctt gagcagcggc agcctcccgg cgcttctccc gccaactcgg ctcgttctcc
    19201 acctcttcac cctagtcgcg gcggtgaagg atgacggtcg gtgggttgag tggaccggaa
    19261 tccgggacgt cggccgcgtg ctcgaggtcc tgcaggtcga agcggtgacc gtactgcctc
    19321 accgcgcagt caacgcccct gaccactacc ggtcactcga ccagctttcc ttcggtggag
    19381 atgtcgtcgc gcatgagctt gcggaactcc tccgggatcg gcgggatcgc ctcacgcagc
    19441 acctgcccag ggccagacca tacgaggttc acctggaggg actcgtcgag gtcggggaag
    19501 tccgagcgat tgtggcagcc gcgggtctcg cgccgttcca gcgccgcgtc gagcgtcgcc
    19561 ctggcggcca gagcggacga cttcaggtcg aacgcgtggg cgaggtcctg gaacccggcg
    19621 atgtcagggt gtacgccgat ccgcgtcatc cgatcctcga tctccgcaag ctccgacagc
    19681 ccggccagca gtccggcttc gtcgcggacc actccggcgc gggcggtcat cgtgtcgcgg
    19741 atcgcccgct gcagagcccg gacgttctcc tgaccgtcgc tcgcaagcag ggcgtcgacc
    19801 tcggtccgtg cttcggcgac ggcgtcggcg gaccggtgtt gcgactgccg gtcgatcgag
    19861 tacttcgctg cctcctcggc cactatccgg ccgaacacga ggagctcgat cagggagttg
    19921 ccgcccaggc ggttggcgcc gtgcaagccg ctggccgcct cgccgatcgc gtacagcccg
    19981 tcgacatcgg tcccgtgatc ctcgggacgg acccacaccc cgcccatcga atagtgcgcg
    20041 gtcggcgcga tctcgatcgg cagcttggtg atgtcgagca tctgcagttc gagcagcgtc
    20101 tgatagaccc gcggcagccg gcgcatgatc gtctcccggg gcaggtggga cacgtccagc
    20161 cagacaccgc cgttcggcgt accgcggccc tccatgatct cggtgtactc cgcgagtgcg
    20221 acccggtccc gcgtggacag ctccatccgg tcggcgtcgt accgggtcat gaaccgctcc
    20281 cccagcgcat tgcgcaactg gccgccttcg ccacgagccg cttcggagac cagggttccg
    20341 gcggcgttct cgggctcgat caggccggac gggtggaact ggaccatctc ggggtcacgg
    20401 atccggccgc cggccaggac cgccagccgg aacgagtcgc cggtgttctc atcccgcctg
    20461 gacgacgtac gccgccagat ccgggtgtgg ccgccggcgg cgaggatgac cgcgtccgcg
    20521 tggatgacgt agcgccgccc ggtggtgagg tcgaacccgt aggcgccgaa gacggcgttg
    20581 tcccggacca ggatgcgggt cacgtagacg gtgtccagga tcgggacgcc tagctggacc
    20641 gcccggttga cgagggtccg ctggatctcc agcccggtgt agtcccccgc gaaggcggtc
    20701 cggcgatacg tgtgggcgcc gaagaaccgc tgcgagatcc tgccgtcggc ctcgcgggcg
    20761 aacggcatgc cgtagcgctc caggtcggcg atgccccggg ccgctccctc cgtgacgatg
    20821 cggaccgtga ccgggttcgc cagcaggtag ctctcctgca aggtgtcggc ggcatgctgc
    20881 tgccaggtgt catccggatc catcgtcgcg agcgccgcgt tgatcccgcc cgccgcgagc
    20941 gaagtgtgcg cgtcggcgcg gggacgcttg cccagcacaa gcacctcgac gccttgctcg
    21001 gccagctcga tcgcggcccg cagcccggca cccccggtcc cgatcaccag gacggacgta
    21061 gcgatctgct gctcggtgac actcatcgac tctccttcgg caactggtct caccacaagg
    21121 accacgcaag ccgccgatct gtgactgtca cggtcatcac accacggggt ggactacgga
    21181 cttccagggc gcggtggcca cggtacggcg gcgaaggtgg aagcagcccc ctcgctaagg
    21241 agccctccac catgagtacg tcggatttcc tccgggttcg cccacgcctg ttcgggatcg
    21301 cctaccgcat cgtcggcaac gtccaggagg ccgaagacgt cgtccaggag gtctggctcc
    21361 gctggcagcg caccgaccgg gcctcggtcg tcgatcccgc ggccttcctc gcgaccatca
    21421 cctcccggct cgcgatcaac gtcgtacagt ccgctcgccg gcggcatgag acgtacgtcg
    21481 cttcctggcc gcgcgaggag agcacgcccg gcggtgtcga tccgcaggaa cgggccgaac
    21541 agcaggagtc catcgatcac gtcgtacggc tgctgctcga acgactgtcg ccggccgagc
    21601 gggcgacgta cgtactgcgt gaagggttcg aatacccgta tctgcggatc gcggagacgc
    21661 tgcggatcgg tgcgcccacc gcgcggcagc tggtgaaacg ggcccgggac cggctctcct
    21721 ccgatcgctg cagtccgtac agccctgccg cgcacagccg cctcctgggc gcgttgacct
    21781 cagccgcacg cgccggcgag ttgaccggac tcgaggaggt tctcaccgcg gggctcgccg
    21841 aggccaactg accaggcagg caccgttccg gtccgcgagc atcggctgtc gtgcaccggc
    21901 ggatggctct aacctctggt gaggtggtgg agccatgacg agcgagcttc gcggtcggcg
    21961 taaggaatgc gcacgcctgg accaggttgt cgccgaggtg cggtcgggcc ggggccaggt
    22021 cctgatcgtt cgtggtgagg cagggatcgg caagaccgcg ctgctcgacc acctggcctc
    22081 gcgcgccgac gggagccgag tcgctcgagc gtccggcgtc gagtccgaga tggagctccc
    22141 gtacgccggt ctgcaccagc tctgcgcacc gatgctcgaa ctggccgagc ggctgccgcc
    22201 tccacagcga caggcgctgg ctgtggcgtt cggcatggag ttcggagggc cgccggacag
    22261 gttcctggtg ggcgccgccg tgttgagctt gctgtcggag gcctccgaca gcaagccact
    22321 gttgtgcgtc gtcgacgatg cgcattggct ggaccaggcc tcggcgcagg cgctgagctt
    22381 cgtcggccgg cgtctgctcg cggaccacat cgggctggtg ttcggcgtcc gggatcccgc
    22441 gaccgcgccc gagtggcgtg gtttcccgga gctgaccgtc ggcggcctgg cggatgcgga
    22501 cgccggggcc ctgctggagt ccgtcgtacc tgggcggctg g
//
