LOCUS       NZ_CP028721            22982 bp    DNA     circular CON 21-NOV-2024
DEFINITION  Enterococcus faecalis strain CVM N48037F plasmid pN48037F-1,
            complete sequence.
ACCESSION   NZ_CP028721
VERSION     NZ_CP028721.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Enterococcaceae; Enterococcus.
REFERENCE   1  (bases 1 to 62234)
  AUTHORS   Tyson,G.H., Sabo,J.L., Hoffmann,M., Hsu,C.H., Mukherjee,S.,
            Hernandez,J., Tillman,G., Wasilenko,J.L., Haro,J., Simmons,M.,
            Wilson Egbe,W., White,P.L., Dessai,U. and Mcdermott,P.F.
  TITLE     Novel linezolid resistance plasmids in Enterococcus from food
            animals in the USA
  JOURNAL   J Antimicrob Chemother 73 (12), 3254-3258 (2018)
   PUBMED   30272180
REFERENCE   2  (bases 1 to 62234)
  AUTHORS   Tyson,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-APR-2018) CVM/OR, FDA, 8401 Muirkirk Rd, MOD2, Laurel,
            MD 20708, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 603x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004332015.1-RS_2024_11_19
            Annotation Date                   :: 11/19/2024 19:35:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,059
            CDSs (total)                      :: 2,981
            Genes (coding)                    :: 2,931
            CDSs (with protein)               :: 2,931
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 50
            CDSs (without protein)            :: 50
            Pseudo Genes (ambiguous residues) :: 0 of 50
            Pseudo Genes (frameshifted)       :: 30 of 50
            Pseudo Genes (incomplete)         :: 21 of 50
            Pseudo Genes (internal stop)      :: 15 of 50
            Pseudo Genes (multiple problems)  :: 12 of 50
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:04:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 28908
            Orig. end                         :: 51890
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP028721.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22982
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22982
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22982
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12982](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12982)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    193..208
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.6"
                     /tool="antismash"
     misc_feature    590..605
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     misc_feature    1202..1220
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 26.49"
                     /tool="antismash"
     misc_feature    2742..2757
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.02"
                     /tool="antismash"
     gene            complement(3049..3135)
                     /locus_tag="C7I32_RS15420"
     CDS             complement(3049..3135)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025321.5"
                     /locus_tag="C7I32_RS15420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_012881081.1"
                     /transl_table=11
                     /translation="MAEKLISLIIAPLLVGLVLLLVDRWLDD"
     misc_feature    complement(3088..3102)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            complement(3227..3442)
                     /locus_tag="C7I32_RS16360"
     CDS             complement(3227..3442)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002415356.1"
                     /locus_tag="C7I32_RS16360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002403560.1"
                     /transl_table=11
                     /translation="MLLSMNITVTEIFMKTYDYRGSVIKEGNKTTSIAYVQCACGCLAS
                     RMSSDSDKYKCSWCKRTYMLGKEIYR"
     CDS_motif       complement(3401..3442)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLLSMNITVTEIFM"
                     /locus_tag="C7I32_RS16360_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(3227..3400)
                     /prepeptide="core"
                     /locus_tag="C7I32_RS16360_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.20"
                     /molecular_weight="6350.3"
                     /monoisotopic_mass="6346.1"
                     /core_sequence="KTYDYRGSVIKEGNKTTSIAYVQCACGCLASRMSSDSDKYKCS
                     WCKRTYMLGKEIYR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLLSMNITVTEIFM"
                     /leader_location="[3400:3442](-)"
                     /alternative_weights="6368.3"
                     /alternative_weights="6386.3"
                     /alternative_weights="6404.3"
                     /alternative_weights="6422.3"
                     /alternative_weights="6440.4"
                     /alternative_weights="6458.4"
     gene            complement(3390..3908)
                     /locus_tag="C7I32_RS15430"
     CDS             complement(3390..3908)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016622434.1"
                     /locus_tag="C7I32_RS15430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_010819054.1"
                     /transl_table=11
                     /translation="MVRRTKKEFKPYNDYVDRPFELKWPTAFPLGELQAAIKETNDYHS
                     REIERLPQLSQAQIEHLLSRSIKQNKVLEIQLNSLDEYERVKPSIRGVFRGMAEFDVVL
                     IGDQQIDFYDIRHIQIHDFYKWSENEPEKQIDNPFSEVKFSELTEEENNAIDAFINEYY
                     SDGDFYEDI"
     misc_feature    3939..3952
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.1"
                     /tool="antismash"
     CDS             3997..4128
                     /gene="allorf_32905_33036"
                     /locus_tag="allorf_32905_33036"
                     /protein_id="allorf_32905_33036"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVGLNEERETKLKRRRPVEQSETNYSSFRVWPCSWYKKLFVFK"
     CDS_motif       3997..4074
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVGLNEERETKLKRRRPVEQSETNYS"
                     /locus_tag="allorf_32905_33036_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4075..4128
                     /prepeptide="core"
                     /locus_tag="allorf_32905_33036_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.10"
                     /molecular_weight="2185.6"
                     /monoisotopic_mass="2184.2"
                     /core_sequence="SFRVWPCSWYKKLFVFK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVGLNEERETKLKRRRPVEQSETNYS"
                     /leader_location="[3996:4074](+)"
                     /alternative_weights="2203.6"
     gene            complement(4269..4493)
                     /locus_tag="C7I32_RS15440"
     CDS             complement(4269..4493)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002387551.1"
                     /locus_tag="C7I32_RS15440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_010819053.1"
                     /transl_table=11
                     /translation="MKNNQMEIKLKEIMDKQGMTLDELKRNVQIDAVLLDVMYNEGLFD
                     DTKVGVQTISELMIALNISKVNELVPKVK"
     gene            complement(4515..4724)
                     /locus_tag="C7I32_RS15445"
     CDS             complement(4515..4724)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002387552.1"
                     /locus_tag="C7I32_RS15445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_025188134.1"
                     /transl_table=11
                     /translation="MMARKKYDHFGIEIGMWNRDNVVNKIECDCGQLANKVRGKHEFFE
                     CAGCGRCYHKELGEYVPLENSNKG"
     gene            complement(4743..5387)
                     /locus_tag="C7I32_RS15450"
     CDS             complement(4743..5387)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002393087.1"
                     /locus_tag="C7I32_RS15450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_010774973.1"
                     /transl_table=11
                     /translation="MAKIGYARVSSTDQNLDRQLELLSNCDKIFSDKASGKDTNREGFQ
                     EMMKFIREGDIVVVTELKRLGRNNKELTETMNLIQLKKATLEVLNLPALTGITDDNLRR
                     LLNNLIIELYKYQAEEERRYIRETQQQGIKLAKQKGRYTGGKRKYSENDPRLQLGFKLF
                     LEGATDKEVEEQIGINRRTFKRYRQRYGITAEKRKKIKDKKNFKHVDEVYN"
     gene            complement(5626..6609)
                     /locus_tag="C7I32_RS15455"
     CDS             complement(5626..6609)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M50"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358185.1"
                     /locus_tag="C7I32_RS15455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="site-2 protease family protein"
                     /protein_id="WP_002365933.1"
                     /sec_met_domain="Peptidase_M50 (E-value: 7.5e-09, bitscore:
                     27.2, seeds: 56, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFISPMIFTLLLVIFTLVFELNLVSTAYFALLLSIFVHELGHLA
                     FGLFNKVRPESLIFGFIKFSWENQFKIRLNTQWGFFGGLFRYKPTTFNNKKILRLLTGG
                     PIFSLFFTLTFFVKIDFFQYFSLFNFSIFLITAVPFNFNGFMNDGYNIYKLVTKDYIFE
                     MYYIVSNSLLNKYNQSTFLNTTEVCKIIKKNKELPLYVLNTFLLYVIYEYLIDKNNRKL
                     KLIYPILSKEDKILNNKSYLQNFYLANLYMIEYILSVDNKQTFKKINLKILDSISRSRI
                     RYLNFKCSKSDDDEISQSMTEFSNIIKNYSDQMSTMIIAEKQWVQN"
     gene            complement(6610..7848)
                     /locus_tag="C7I32_RS15460"
     CDS             complement(6610..7848)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358184.1"
                     /locus_tag="C7I32_RS15460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_002365932.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.2e-37, bitscore:
                     120.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRGLTYILISYIFLILGTTGYASDLSNNISFFIDNSQTTAIEE
                     IESELSSEKVDYIQEIGLVSFKNLDDSDRKFIGKYFNVSEGKKLPDFKPEEVNSSILNI
                     NILNKDFKSFNWPYKKILSHIDPVKEQLGKDITIALIDSGIDRLHPNLQDNNLRLKNYV
                     NDIELDEYGHGTQVAGVIDTIAPRVNLNSYKVMDGTDGNSINMLKAIVDATNDQVDIIN
                     VSLGSYKNMEIDDERFTVEAFRKVVNYARKNNILIVASAGNESRDISTGNEKHIPGGLE
                     SVITVGATKKSGDIADYSNYGSNVSIYGPAGGYGDNYKITGQIDAREMMMTYYPTSLVS
                     PLGKAADFPDGYTLSFGTSLATPEVSAALAAIMSKNVDNSKDSNEVLNTLFENADSFID
                     KNSMLKYKEVRIK"
     gene            complement(7845..9989)
                     /locus_tag="C7I32_RS15465"
     CDS             complement(7845..9989)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002415198.1"
                     /locus_tag="C7I32_RS15465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_002365931.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2e-43, bitscore:
                     139.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLKYVAQGEHSECALACITMLLNYYGNQSTLVELREKYGVPKG
                     GLTIKNIRTVFDEYGFDVSTFKSSFSNYLDLPTPVISYWNNQHFVVIEKIKKKKVLILD
                     PASNKRWIDISEFKKNFSNILIYAHKKKTKKEGKRKQFFLKSFIFTKFKRYFFSLIILS
                     FVSQLLLLLIPIATKYSIDNIRSFQEIPTYVLLLILTSFFSVLYVVQYLKSSVVAEFQY
                     EFDFKLMFSYIDKLFSMPLMYFSNRSTGELVFRANLNIYIRQILSQKVITTLIDSLFLG
                     IYLFLMVNYSILLTIIALVLISLIAFLSIINSHTIKRFVDKEIMEQGNVQRIITEAIEG
                     IETIKSANAEKSFLLNWKNMFTSQLLITKNKNRYIAIFGILPEIIQSVMPALFLIIGIK
                     LIINNSLSLGSLIGFVSIVTMVMKPILSLVSSYNDFLLLNVYFQKLSEVLTYEEKNDFN
                     NKKGNVGKEEFIYRVNNVYYTISVFEKNILNGISFDIRKGDKVAIVGRSGSGKSTLLKL
                     LAGLLQPSNGEILYEGYPLSNNSNNRRNIFYVNQNAHIFNETIEKNISLEFKPNSSINE
                     KKRLKESMSKSKMDEVLLGIPQYEKTIVSENGSNFSGGQRQKIALARAFYSNVNTLLLD
                     EPTSAMDNISEFEVFSNLLDEKRTVITVAHRISTVKNFDKIILMDNGEIVCIGKHEDLI
                     ENSELYRSLYYKKQQFGGTK"
     gene            complement(10001..12982)
                     /locus_tag="C7I32_RS15470"
     CDS             complement(10001..12982)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002368286.1"
                     /locus_tag="C7I32_RS15470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_002365930.1"
                     /sec_met_domain="DUF4135 (E-value: 7.3e-95, bitscore:
                     310.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.2e-52, bitscore:
                     168.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDNLINVLSINERCFLLKQSGNEKYDIKNLQAWKERKSVLKQDD
                     LDYLIKYKYESLDNFGLGITPIENFPDKEVAIQYIKDQSWYIFFESILDSYNDSEEQLL
                     EVDASYPFRYFLQYARLFLLDLNSELNICTKEFIINLLENLTQELIHLTSKTLVLDLHT
                     FKKNEPLKGNDSSKRFIYYLKKRFNSKKDIIAFYTCYPELMRITVVRMRYFLDNTKQML
                     IRVTEDLPSIQNCFNIQSSELNSISESQGDSHSRGKTVSTLTFSDGKKIVYKPKINSEN
                     KLRDFFEFLNKELEADIYIVKKVTRNTYFYEEYIDNIEINNIEEVKKYYERYGKLIGIA
                     FLFNVTDLHYENIIAHGEYPVIIDNETFFQQNIPIEFGNSATVDAKYKYLDSIMVTGLV
                     PYLAMKDKSDSKDEGVNLSALNFKEQSVPFKILKIKNTFTDEMRFEYQTHIMDTAKNTP
                     IMNNEKISFISYEKYIVTGMKSILMKAKDSKKKILAYINNNLQNLIVRNVIRPTQRYAD
                     MLEFSYHPNCFSNAIEREKVLHNMWAYPYKNKKVVHYEFSDLIDGDIPIFYNNISKTSL
                     IASDGCLVEDFYQESALNRCLNKINDLCDEDISIQTVWLEIALNIYNPYKYINDLKNQN
                     SNKYIYTGLELNSKIIQACQKIEKKIFKRAIFNKKTNTVNWIDIKLDQDWNVGILNNNM
                     YDGLPGIFIFYVALKYITKNHKYDYVIECIKNSIYTIPSEDILSAFFGKGSLIYPLLVD
                     YRLNNDINSLNVAVEIADMLIEKKPINNGELKNDWIHGHNSIIKVLLLLSEITEDEKYR
                     KFSLEIFEKLSEEPYFNFRGFGHGIYSYVHLLSKFNRIDKANSLLHKIKESYFEEEPKN
                     NSWCKGTVGELLATIELYDDNISNIDINKTIEYKNKDCLCHGNAGTLEGLIQLAKKDPG
                     TYQYKKNKLISYMLNDFEKNNTLKVAGSEYLESLGFFVGISGVGYELLRNLDSEIPNAL
                     LFEL"
     gene            complement(13043..13234)
                     /gene="cylL-S"
                     /locus_tag="C7I32_RS15475"
     CDS             complement(13043..13234)
                     /codon_start=1
                     /gene="cylL-S"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358181.1"
                     /locus_tag="C7I32_RS15475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthipeptide cytolysin subunit CylL-S"
                     /protein_id="WP_002358181.1"
                     /transl_table=11
                     /translation="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGSGDVQAETTP
                     ACFTIGLGVGALFSAKFC"
     CDS_motif       complement(13127..13234)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /locus_tag="C7I32_RS15475_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13043..13126)
                     /prepeptide="core"
                     /locus_tag="C7I32_RS15475_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="2632.0"
                     /monoisotopic_mass="2630.3"
                     /core_sequence="GDVQAETTPACFTIGLGVGALFSAKFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /leader_location="[13126:13234](-)"
                     /alternative_weights="2650.0"
                     /alternative_weights="2668.0"
     gene            complement(13268..13474)
                     /gene="cylL-L"
                     /locus_tag="C7I32_RS15480"
     CDS             complement(13268..13474)
                     /codon_start=1
                     /gene="cylL-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358485.1"
                     /locus_tag="C7I32_RS15480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthipeptide cytolysin subunit CylL-L"
                     /protein_id="WP_002358485.1"
                     /transl_table=11
                     /translation="MENLSVVPSFEELSVEEMEAIQGSGDVQAETTPVCAVAATAAASS
                     AACGWVGGGIFTGVTVVVSLKHC"
     CDS_motif       complement(13403..13474)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENLSVVPSFEELSVEEMEAIQGS"
                     /locus_tag="C7I32_RS15480_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13268..13402)
                     /prepeptide="core"
                     /locus_tag="C7I32_RS15480_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="4019.5"
                     /monoisotopic_mass="4017.0"
                     /core_sequence="GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKH
                     C"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENLSVVPSFEELSVEEMEAIQGS"
                     /leader_location="[13402:13474](-)"
                     /alternative_weights="4037.6"
                     /alternative_weights="4055.6"
                     /alternative_weights="4073.6"
                     /alternative_weights="4091.6"
                     /alternative_weights="4109.6"
     misc_feature    13877..13892
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.29"
                     /tool="antismash"
     gene            13878..14078
                     /gene="cylR2"
                     /locus_tag="C7I32_RS15490"
     CDS             13878..14078
                     /codon_start=1
                     /gene="cylR2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002370931.1"
                     /locus_tag="C7I32_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytolysin regulator CylR2"
                     /protein_id="WP_002358483.1"
                     /transl_table=11
                     /translation="MIINNLKLIREKKKISQSELAALLEVSRQTINGIEKNKYNPSLQL
                     ALKIAYYLNTPLEDIFQWQPE"
     gene            complement(14524..15837)
                     /locus_tag="C7I32_RS15495"
     CDS             complement(14524..15837)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383787.1"
                     /locus_tag="C7I32_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002406537.1"
                     /transl_table=11
                     /translation="MEDRSDIVINKVEKRDILILSSFVFVVMLIYNFGIKQMEFGDDAF
                     FLKQFTHDFQSNYYEFLEFRYNEWTSRLVIEIALTQAVQHVFLWRVLNAIAMSIVAIVP
                     ALLFNSDNSRRGLIIGTGMSLLIPASMINNAGWIATTTNYVWVMAAALLSIWPIMNYIR
                     GKSVNWLSLILSLVFLIYATNQEQMVVIMLVSLLILAGILFLSKKNILITLPHIAIVIA
                     SFVFILTCKGNAARNVQETKQWLPNFSSYSIFDKLQIGYSSTLKALFFEWSPLMLAFVL
                     LILTAGLVKNGTLVKKMISGIPLLTYLICTRFNTIIDQTYDIVSGKTYMSLVVLLTGLV
                     FLYVIGIFGASNNPLEFLSVIFLLILGVGSRIMMGFSPTIWVSGSRTYYFTYVLIMMSG
                     VYLISQLPENNQSRTFKVLFGYFLVLALLLIMMYTKIL"
     gene            complement(15827..15958)
                     /locus_tag="C7I32_RS16445"
     CDS             complement(15827..15958)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159353.1"
                     /locus_tag="C7I32_RS16445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000159353.1"
                     /transl_table=11
                     /translation="MTKEEKIILIVRNSDFTYEELEKLPMSSIDSIYKAHVLEKNGG"
     gene            complement(15961..16824)
                     /locus_tag="C7I32_RS15500"
     CDS             complement(15961..16824)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865436.1"
                     /locus_tag="C7I32_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA/RNA non-specific endonuclease"
                     /protein_id="WP_000865436.1"
                     /transl_table=11
                     /translation="MKVKRKKQPYWLGSLLSLVIIGFGLLNHLDLSEQLSSFLSNDIFQ
                     EVAKSDKKSLTKKPRNVKTKKSTSAPYDQQQYNQLANLDFQSGGKAAIEVNNGQSSLDI
                     ATWKENKVIYGDLDSLNRTTFVTAYLDRKNLGRSEGRERQVWQPTGWHQKQIDGDPIVN
                     RGHLLAYTSSFNFDIDGNFKIGENGSQDNPKNLATQTAFSNQKVQTHYEKLVRDAQKLK
                     GNKVIYQIVTVFRGKELMPRGYWLQAIDSAGTLNFNVYEYNVQPNVVFNYEEGTSQIDR
                     TMKVRE"
     gene            complement(16814..17254)
                     /locus_tag="C7I32_RS15505"
     CDS             complement(16814..17254)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209505.1"
                     /locus_tag="C7I32_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002406538.1"
                     /transl_table=11
                     /translation="MREVTAQQLLTEFSIIEKMAQSDAIKQRFCLDNYLAEDVKSAINE
                     LNSLYPAYHFEYQEVFGGFGHDLVVTDIAQKVTYDRIPKTRTYGELFQTLAKVYGIHSS
                     AKFHHKPTDRLTEEEFQETIKFYENFDIDTLFSQDEDKYDES"
     gene            complement(17251..17394)
                     /locus_tag="C7I32_RS16225"
     CDS             complement(17251..17394)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000066155.1"
                     /locus_tag="C7I32_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000066155.1"
                     /transl_table=11
                     /translation="MSNKELSKKYQESLKQRREKQTKRERALEGTVIAPLTDKNNRKDK
                     NK"
     gene            complement(17468..18403)
                     /locus_tag="C7I32_RS15510"
     CDS             complement(17468..18403)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002365925.1"
                     /locus_tag="C7I32_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002365925.1"
                     /transl_table=11
                     /translation="MTLTTEVFHDFLCSSQQTFIFQEEKQTKSLVKIMIDPKSTRFFSV
                     FLNPFLQDGESLSFRQNESIGDVIGIYDSVTDTFFSQAEYLIEWHLKGVDITGFKDLHE
                     VIQQLERELAEQTLAEINQHYNYYYTLEGKYLADLSDWKITTLKNEVRKKLLDGQTTFI
                     MDHSFVQYECADSEILDLLTEKQATQSRLVKKYLEKNARMLSEHLQKLQFQQQYAKELA
                     ENKQFQKEKEIIQAVQNKGMKTITVTYQISDKELTFKMRNIIDSSRDYFSSYDITNKKE
                     RDAYDTLTREAIDLQKIKQISYGRKVLYAE"
     gene            complement(18545..18742)
                     /locus_tag="C7I32_RS15515"
     CDS             complement(18545..18742)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001031355.1"
                     /locus_tag="C7I32_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_001031355.1"
                     /transl_table=11
                     /translation="MNKEQAFQTLDSLVYAMEKLENESIRSEDNEELEQMLALMNRDWH
                     ELYTIYGKAWEEYRKNALEK"
     gene            19313..19459
                     /locus_tag="C7I32_RS16515"
     CDS             19313..19459
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010746377.1"
                     /locus_tag="C7I32_RS16515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative holin-like toxin"
                     /protein_id="WP_141435800.1"
                     /transl_table=11
                     /translation="MNVLPKSIERRSLLSVSESLQLMLAFGGFTLTLITTIVAILNYKD
                     KKK"
     gene            complement(19678..20154)
                     /locus_tag="C7I32_RS15535"
     CDS             complement(19678..20154)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615486.1"
                     /locus_tag="C7I32_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_002406539.1"
                     /transl_table=11
                     /translation="MIQLSAVGRLTKGAELRITTNGKSVANVTLACKRKRPDTNGNVPT
                     TFIQCVLWGKPAQVFAKYTQKGALVGVNGELQTRSYDDQQGVTHYVTELVVEDFEFLES
                     KETVQKREEKQHAVPQGQSTPTVNEQPAMNQAPTQQNVYQQPSMNGLSEYGYNQ"
     gene            complement(20293..21627)
                     /locus_tag="C7I32_RS15540"
     CDS             complement(20293..21627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002406540.1"
                     /locus_tag="C7I32_RS15540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PcfJ domain-containing protein"
                     /protein_id="WP_002406540.1"
                     /transl_table=11
                     /translation="MNKKTPKPLTPPKAFFNWCTAQIPTYEWQNKKETILASSRKNCPT
                     IKKRLTKYSRLSFPTKFYSFGIILVRAKRIEIQTHSYWQTITDGTETLIYEPSNLERFS
                     NDTHVKAHYENGHWHEGLLANYGYMSSAYTNTVFYSNNWQEKLTTISELKYLKLPTISR
                     QELAHVYKYRNEIEFLQKIGATTLANEILFDDERNIFGTWHKKVDMRVITKNWLKANKK
                     RLKTTNPTFHMLMLEKTLKERKVARIEGIENYLHYSQIKQLPKEVNLTKFQHWFMRKGE
                     RFSYYMDYLHMLEELNTPFTDDVLFPENLQLAHDNATNTLNLLERELEEQQYQERKKQL
                     KALETEIDDLLFLAPHSLQEIVEEGQVLHHCVGSQHYLEQHTKGKTTIVFIRRKEEPDK
                     PYFTLEYREKRVIQVQGKYNRGHIPEEVEEAIEQWQIEIEKAMPS"
     gene            complement(21624..22400)
                     /locus_tag="C7I32_RS15545"
     CDS             complement(21624..22400)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002398548.1"
                     /locus_tag="C7I32_RS15545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Cas9 inhibitor AcrIIA9 family protein"
                     /protein_id="WP_002365921.1"
                     /transl_table=11
                     /translation="MDFQNIQTVKELRYALKQYKQTLATTIFDDTQGYISVAFKKEVIE
                     KDGKNVQFLCFYPNYEVALYPVETLLAYLEKLPEQAIVTIKDHDGNYSSLFLTIDETID
                     QGNNYQWLVISDKNSYERFFFTAQESTQEQAFEKMLKELETDHDSTLEVVHNWLCRQTD
                     EALFLGILKEDRTLKGAMTYCIGKAQEQSKDQSSAMVADEVVFSWIKEYFLLEKLPETK
                     AVGKVTTTNKKKPTKKSETKPERKEVDEQIDLFECV"
     gene            complement(22562..22828)
                     /locus_tag="C7I32_RS15550"
     CDS             complement(22562..22828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245899.1"
                     /locus_tag="C7I32_RS15550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_001245899.1"
                     /transl_table=11
                     /translation="MRNRIEELKEQARTELNEWGLIIDGCFEGDFETWIGCYARPKDKP
                     TALDPINEEEAKEQAKYAVNGFPQDFTEWYEWEINNGKLKNLL"
     misc_feature    22891..22903
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    complement(22921..22936)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.18"
                     /tool="antismash"
ORIGIN
        1 aaaaggcgac aaacaaaaga tgatcatgtc aagttaatta aaaatattta tgggtataaa
       61 gagtttagcc atctaaaaaa gtatttaagt aattggctat taaatagggc catttatact
      121 acagaatcta caaatatgct ctttgatatg cttctaaaaa aatgtttaga tgagaaaata
      181 atattaccag ggtttactac tttttcacgt tttatagcta gcatcgttga aaaagctgaa
      241 gagcaattat ataaacaatt agcattaatt ccaacgaata aggagaaaaa acaactctta
      301 aatcttttag aattagttgg aacacctgtt tatggagcaa caattaaaat ggatatttta
      361 agaactcctt tgactgacta cagtttgaaa gaaatttcta gaggatttga acgattaaaa
      421 caattccaaa ctttttctac agaaaactgg caaataaaat taattcctga aggaaaaata
      481 aaaatattag ccaattatgc atttaaagct aaagcccaat tgattcaacg tatgagtgaa
      541 cagaaaaaaa tagctttgtt agtagcattt atttatatct ataaacgaaa agctatggac
      601 gaacaaattt tagccctggt taattttttt gaaacaattt ttagacgtgc taagaataaa
      661 gaagctaatg aaagacttcg gacaattaaa gatttagacc gtgcagcttc aacactttca
      721 gatattgttg aatttgttat gacagaatcc tctaataaca gtgatagttc tatacgtagt
      781 caaattttaa aaaaatattc tgaagaaagc atttattctg cagtcacaca agttagaaaa
      841 ttagtgaaaa atgagcaaga acctattgct attgttgaac ttctaactac ttatcgaaag
      901 tttaaaaaat ttattccgga tattttaatt actttaaatt tcgacagcaa caactatgga
      961 aataattgta aagaactttg gtctttcata aataatcgtt tccctaaccc aatcacttat
     1021 aaaatgtttc aaacaattga acatactctt ccaaaaaaat gggtttatta tattcaagaa
     1081 aatccaaatc agactaataa atgtgtttta attgccgcaa ttgaatgctt aattcaatcg
     1141 ttcaaacggc atgatatcta tatttcccaa agcaatcttt ataacaatcc tatggattgt
     1201 ttactggata aacaaacatg gcttcaacaa aaagggattg tattagaaca actaggtcta
     1261 ccttcttctg gagaagaagt atctttatgg ttaaaaaaag atttagatct ttcttacaaa
     1321 gaagcattaa gacgttggcc tacttctaat atggctcgaa tagaaaataa taatcaatta
     1381 attgtttcca gattaaaaaa agtttatgaa aataaagaag agaaagcgtt taaattacgt
     1441 attcaacaat tattacccaa aattgattta acagatttgt tattagaagt aaatcaacaa
     1501 ttaaatctta ctcaactatt taatcactta aatgacaaag acacaaaaat gaaagactta
     1561 gatattagtt tactagctgt tcttttatca gaagcttgta atatcggttt ttctccagtt
     1621 tcaaaaaata gtattgattc gttaaaatat gatcgcctaa tctatgttaa tcaccactat
     1681 attcgagtag acacgctctc tgcagctaat caaaaaatta ttcatgcaca ccgaaaactt
     1741 gctataacta aattatgggg agacggttat atggcatcag ctgatggtat tcgttatatt
     1801 actccacaac gttctctata ttctaaaagc aacccaaaat attttgggcg tggtcgagga
     1861 attacttttt ataattttat ttctgatcaa tatataggat ttcatggtat ggttgtttct
     1921 ggtacactcc gtgattcatt gtacttatta gaaggatttc ttaatcaacc tagcgagcta
     1981 actcctaatc agataatgac agatacagct ggttatagtg atatgatatt tgggcttttt
     2041 gccttattag gattccaatt tagcccgcga atcgcaaatg ataaaggaac aaaactttgg
     2101 cgaattgatt ctgatgcgga ttatcacgaa cttaatacac tatcacaaaa taaaatcaat
     2161 ttaacactta ttcaaactta ttgggaagaa atccttcggg tagcaggttc cttaaaatca
     2221 ggtaaagtta atgcgacaga gttaacaaaa gcacttcaac gaaatgggca accaacagag
     2281 ctaggtaaag ctattactga atatgggaaa gtgtataaaa caaaacatca gcttcgctat
     2341 atttctgacg aaatttatgc acgacaaatt ctagaacaat taaacaaagg agaatcacgt
     2401 catgctttat gtcgaaatat tttttatgga cgtaaaggaa aattatacca aacctattat
     2461 gatggaatgg aagaacagct taatgcatta ggattggtta ctaatgccat tatctattgg
     2521 aattcattgt atttagaaaa agtctttgaa caaatgaaaa aagaaggata tgattgttca
     2581 gaagaaatgt tacgaaaaca atctccttta attagtgatc atattaattt tgttggcaag
     2641 tacaccttta aatatgaaca agaactttct gatggaaaat tacgtccatt aaatttggaa
     2701 aaattttagt aatgttcgtc tttttttatt accgtgcatt ttcgtatgaa tgttccaata
     2761 aaatatttag catagaaaag tagataatca caagaatcgt atgaaatcaa cgtttcttgt
     2821 gattatattt ttatcctacc gtgcattttc gtttctatgt tccatgtacc cctatctgct
     2881 tcttttttgt tgacctcttt taataatatg ttatactgaa ggtgcgaagc gaaattagtt
     2941 caacagcaca gttacaccaa aaagcccccc tatttgcggt aggagggctt tttttgcgct
     3001 gttgcgactt cagcgttgga gttagaaggc aactgcttag attatcggct aatcgtctaa
     3061 ccaacgatca actagcaaaa gtactagacc cacaagtagc ggtgcgataa tcaacgaaat
     3121 tagtttctca gccatagtta caccacctta cttggcagtt gccgcaacaa ttataacata
     3181 aattcaaaat atccctatgg acttttaaaa ccttcagtac tttatttcat ctataaatct
     3241 cttttcctaa catatacgtt cgcttacacc aggaacactt gtatttatca gaatcacttg
     3301 acattctact tgccaaacag ccacacgcac attgtacata agcaatacta gttgttttat
     3361 ttccttcttt gattactgat cctcgataat catatgtctt cataaaaatc tccgtcactg
     3421 taatattcat tgataaaagc atcgattgcg ttgttttctt cttcggttaa ctctgaaaat
     3481 tttacttctg aaaaaggatt gtctatctgt ttttcgggtt cgttttccga ccatttgtaa
     3541 aaatcatgta tttgtatgtg cctaatatcg taaaaatcga tttgctgatc tccaatgaga
     3601 acgacatcga attcagccat gccacgaaat acaccacgta tagaaggttt tacacgctca
     3661 tattcatcta aggaattaag ctgaatttct agaaccttat tctgtttgat tgagcgactt
     3721 agcaagtgtt ctatttgagc ctgtgacagc tggggtaaac gttcaatttc tcttgaatga
     3781 taatcattcg tctctttgat tgctgcttgt aattccccta aaggaaaggc tgttggccac
     3841 ttcaattcaa agggtctatc gacgtaatca ttgtatggtt tgaattcttt tttcgttctt
     3901 cttaccattt tgaacactct ccttacttga acattatacg aacaaacgtt cccataatca
     3961 agtgctagat ttattgtata cctgaaaact tttagtttgg ttggactgaa cgaagagagg
     4021 gaaaccaaac taaaacgtcg aaggccagtt gagcaaagcg aaactaatta ttcgtctttt
     4081 cgggtttggc catgttcctg gtataaaaaa ttattcgtat ttaaatagaa atctttttat
     4141 tatttccgcc tgcagatcac catttaatct tgtaaaagcg aacgttaaaa caccttcatt
     4201 gcataactac cgatcaatat ttgtgaaaat ggcttagaat tgctctctca aatctaaatt
     4261 ctagtttctt attttacttt tggtactaat tcatttactt ttgaaatatt taaggcaatc
     4321 attaactcac tgattgtttg tacacctact tttgtatcat caaatagtcc ttcattgtac
     4381 attacatcta gtaatactgc gtctatttgt acatttcttt tcagttcgtc aagtgtcatt
     4441 ccttgtttat ccatgatttc ctttaacttg atttccattt gattattctt cataactttt
     4501 tccttctttc ttttttatcc cttattacta ttttcaagtg gcacatattc tccaagttct
     4561 ttatggtaac aacgaccaca gccagcacat tcaaaaaatt catgcttgcc tcgtacttta
     4621 ttggccagtt ggccacaatc acactctatt ttatttacta cattgtctcg gttccacata
     4681 ccaatttcaa taccaaaatg atcatatttt ttcctagcca tcacttaaag tcctccagtt
     4741 ctttaattat acacttcatc cacgtgctta aagttcttct tatcttttat tttttttcgt
     4801 ttttctgcag taattccata acgttgacga tatctcttaa aagtccttct gttgatacca
     4861 atttgttctt caacttcttt atctgttgca ccttcaagaa atagcttaaa tcctaactga
     4921 aggcgtggat cgttttcact gtattttcgt tttccccctg tgtatctacc tttttgcttt
     4981 gctaacttaa ttccctgttg ctgcgtttca cgaatatagc ggcgttcttc ttctgcttga
     5041 tatttgtata attcgattat caagttatta agtaaacggc gcaaattatc gtcagttatc
     5101 cctgttaaag ctggtaaatt caatacttca agcgtagctt tcttcagctg aattaaattc
     5161 atcgtttctg ttaactcttt attatttcgt cctaaacgtt ttaattccgt cacaacgaca
     5221 atatcacctt cacgtatgaa tttcatcatt tcttgaaatc cttctcgatt ggtgtctttt
     5281 ccgctagctt tgtctgaaaa aattttatcg caattagaaa gcagctctaa ttgcctatct
     5341 aaattttgat ctgtactgct cacacgtgca taacctattt ttgccataag aatactctcc
     5401 attttaaaat tctgttgccc aaccctgttg accctctgaa aatccaagta taccatagct
     5461 agacaaaaga accaacaggg tataccctgt tggttctttt agttaatata ttttaacaga
     5521 aaatttattt attacatcat gaaatactgt ataaaaatcg tagcaagcac acatcacttt
     5581 tgttagccta tcattttacg tcgacagtct agctggtttc ttatctcaat tttgaaccca
     5641 ttgtttttct gctataatca tagtcgacat ttgatctgaa taatttttta tgatattgct
     5701 aaattctgtc attgattggc ttatttcatc atcatcactt tttgagcatt taaagtttag
     5761 atatctaatt ctagatctac taattgagtc tagaattttt aaatttattt ttttaaaagt
     5821 ttgtttatta tctacagata aaatatattc tatcatatac aaattagcca aataaaaatt
     5881 ctgtaaataa cttttattat tcagtatctt gtcttcttta ctaagtattg ggtatattag
     5941 ttttaatttc ctattatttt tgtctattaa atactcatat ataacataca ataagaatgt
     6001 atttagcaca tataatggta attctttatt tttttttatt attttgcata cctcagtggt
     6061 atttaagaaa gttgactgat tatatttatt aagtaagcta tttgatacaa tataatacat
     6121 ttcaaaaata taatccttag taactaattt atatatattg tatccatcat tcataaaccc
     6181 gttaaaatta aaaggaactg cagtaattaa aaatatcgaa aaattaaata aagaaaaata
     6241 ttgaaaaaag tcaattttta caaaaaaggt taatgtaaaa aaaagactaa atattggtcc
     6301 cccggttaac aacctcagaa ttttcttatt attaaacgta gttggtttat atctaaataa
     6361 tccaccaaaa aatccccact gtgtatttaa tctgatctta aactgatttt cccacgaaaa
     6421 ttttataaac ccaaatatta atgactctgg tctaacttta ttaaataatc caaaagctaa
     6481 gtgccctaac tcatgtacaa agatagacaa taacaaggca aagtatgctg tagacactaa
     6541 atttaattca aaaacaagag taaagattac gagaagtaac gtaaagatca tcggagatat
     6601 aaatttcatc tattttattc tcacctcttt gtatttaagc atgctatttt tatctataaa
     6661 agaatcagca ttttcaaata aagtatttaa tacttcattt gaatctttag aattatctac
     6721 attctttgac ataatagctg ctaaagctgc gcttacttct ggagttgcta aacttgttcc
     6781 aaaagaaagt gtataaccat ctggaaagtc agcagctttg cctagtggag aaactagcga
     6841 tgtagggtaa taagtcatca tcatttcacg agcatcaatt tgtcctgtta ttttgtaatt
     6901 gtcaccatat cctcctgcag gaccatatat agatacatta gacccataat tagaatagtc
     6961 agcaatatca ccactctttt ttgtagctcc gacggtaatt acagactcta gtcctcctgg
     7021 tatatgtttt tcattaccag tgcttatatc acgcgactca tttcctgctg atgcaacaat
     7081 tagaatgtta ttttttcttg catagttaac aacttttctg aatgcttcta cagtaaatct
     7141 ttcgtcatct atttccatat ttttatatga tccaagactc acatttatta tatctacttg
     7201 atcatttgta gcatcaacta tagctttaag catatttata gagtttccat ctgtcccatc
     7261 catcaccttg taagaattta aattcactct tggagcaatc gtgtctatta ctccagcaac
     7321 ttgtgtacca tgaccatatt catctaactc aatatcatta acatagtttt ttaatcttag
     7381 gttattgtct tgaagattag gatgaagcct atcaatcccc gagtcaatta gagctatggt
     7441 tatatctttc cctagttgtt ctttcactgg atcaatatga gataaaattt ttttatatgg
     7501 ccaattaaaa gacttaaaat ctttgtttaa aatattaatg tttaaaatag aactattaac
     7561 ttcttcaggt ttaaaatctg gtaatttttt cccttccgaa acattaaaat atttacctat
     7621 aaacttccta tcactatcat ccaggttttt aaaactaact aatcctattt cctgtatata
     7681 atctactttt tcagaagata attcagactc aatttcttct atagcagttg tttgcgaatt
     7741 atcaataaaa aatgaaatat tatttgagag atctgatgca taacctgttg ttcctaatat
     7801 taaaaaaata tatgagatta aaatataagt caatcctctt tttttcattt tgtacctcca
     7861 aattgttgtt ttttgtaata cagtgaacga tataactcgc tattttcaat aagatcttca
     7921 tgctttccaa tacatactat ttcaccatta tccattaata taattttatc aaagtttttc
     7981 acggtactaa ttctgtgagc aacagtaata actgttcttt tctcatctaa taaattagaa
     8041 aaaacttcaa attctgaaat attatccatt gcagatgtag gctcatctaa aagtaatgta
     8101 ttcacattag aatagaacgc tctagctaaa gcaatctttt gcctttgacc accagagaaa
     8161 ttactaccat tttctgatac tatagttttc tcatactgag gaattcctaa aagtacctca
     8221 tccatttttg atttactcat actttctttt agtctttttt tctcatttat agaagaattc
     8281 ggtttaaact ctaaagaaat atttttttcg atagtttcat taaaaatatg cgcattttga
     8341 ttaacataaa aaatgtttct tctattattg gagttgtttg ataaaggata gccttcatac
     8401 aatatttctc cattagaagg ttgtaacaat ccagccaata gttttagtaa agtagatttc
     8461 cctgacccac ttctaccaac aatagcaact ttatcccctt ttcttatgtc aaaagaaata
     8521 ccatttaaaa tatttttttc aaaaacagat atagtatagt aaacattatt aaccctataa
     8581 ataaactctt cttttccaac atttcctttt ttattattaa aatcattttt ttcttcataa
     8641 gttaaaactt cagataattt ttgaaaatat acatttaata gtagaaagtc attataagag
     8701 gaaaccaaac ttagaattgg cttcataacc attgttacta tagaaacaaa accaattagt
     8761 gatcctaatg acaaagaatt gttgattatt aatttaatac ctattattaa aaatagagct
     8821 ggcattacac tttgtatgat ttctggtaat attccaaaaa tagctatata tctattttta
     8881 ttttttgtaa ttaatagttg agacgtaaac atgtttttcc aatttaacaa aaaactcttt
     8941 tctgcattag cagatttaat ggtttcaatt ccttcaattg cttctgtaat aattctctgg
     9001 acgtttcctt gttccattat ttctttatct acaaatcttt ttattgtatg cgaatttata
     9061 atacttaaaa aagctattaa agagattaga acaagagcta ttattgtcag taaaatagaa
     9121 tagttaacca ttaaaaacaa atatatccct aaaaaaagac tatctattaa agttgttatt
     9181 accttttgag acaatatttg cctaatataa atatttaagt tcgctctaaa cactaattct
     9241 ccagttgatc tattactaaa atacattagt ggcatactaa aaagtttatc aatataagaa
     9301 aacattaatt taaaatcaaa ttcatactga aattctgcta ctacagagct ttttaagtat
     9361 tgaactacat ataaaacaga aaaaaaacta gttaatatta ataacagaac ataggtagga
     9421 atttcttgaa aagatctaat attatctatc gaatactttg ttgcaatagg aattaagagt
     9481 aataaaagtt gtgaaacaaa tgataatatt attaaactaa agaaatatct tttgaatttt
     9541 gtaaaaataa atgactttaa aaaaaactgt ttccttttgc cttctttttt agtctttttc
     9601 ttatgtgcgt atattaatat atttgaaaaa ttttttttga attctgaaat atcaatccag
     9661 cgtttattac ttgcaggatc taagattaat actttcttct tttttatttt ctctatgacc
     9721 acaaaatgtt gattattcca ataacttatt acaggagtcg gaagatctaa ataatttgaa
     9781 aaacttgatt taaatgtcga tacatcaaat ccatattcgt caaagacagt acgaatattc
     9841 ttgatagtta gtcctccttt gggcacccca tatttttccc ttagttctac tagtgtactt
     9901 tgattaccat aataattaag tagcatagtg atacatgcca aagcacattc actatgctct
     9961 ccttgcgcaa cgtacttcaa tcttttcata attacacctc ttataactca aaaagtaatg
    10021 cattcggaat ttcagaatct aggtttctca ataattcata acccacacca ctgattccta
    10081 caaagaatcc tagtgattct aaatactcac ttccggcaac ctttagtgta ttattttttt
    10141 caaaatcatt taacatatag ctaataagtt tatttttttt atactgataa gttccaggat
    10201 cttttttagc taattgaatt agaccttcta aagtacctgc atttccatgg cacagacaat
    10261 ctttattttt atattctatg gttttattaa tatctatatt tgaaatgtta tcatcatata
    10321 attcaattgt cgctaaaagt tcacctacag ttcccttaca ccaactattg tttttaggtt
    10381 cttcttcaaa gtatgattct ttaattttat gaagtaaaga atttgcctta tctatcctat
    10441 tgaattttga tagaagatgg acatagctat atataccgtg tccgaatcct ctgaaattaa
    10501 aatagggttc ttcggataat ttttcaaaaa tttctaatga aaattttcta tatttttcat
    10561 cctctgttat ctcggataac aataataaaa cttttattat actattatgc ccgtgtatcc
    10621 aatcattttt taactcgcca ttatttatcg gtttcttttc aatcaacatg tctgcaattt
    10681 ctacggctac atttaaagag tttatatcat tatttaagcg gtaatctaca agtaaaggat
    10741 atattaaact tccttttcca aaaaaagctg acaatatatc ttcagatggt attgtataaa
    10801 ttgaattttt tatacattca attacatagt catatttatg attctttgta atgtatttaa
    10861 gagccacata aaatatgaat ataccaggca atccatcgta catattatta tttaggattc
    10921 ccacattcca atcttgatcc aactttatgt caatccaatt tacagtattg gtttttttat
    10981 taaaaatagc tctcttgaaa atttttttct ctatcttctg acatgcttga ataattttac
    11041 tgtttagctc taagccagta taaatatatt tatttgaatt ttgatttttc aaatcattaa
    11101 tatatttata tggattataa atattcaaag caatttctag ccaaacggtt tgaatagaaa
    11161 tatcttcatc acaaagatca tttattttat ttaggcatct attcagagcg ctttcttgat
    11221 aaaaatcttc tactaagcac ccgtcactag ctattaatga tgtttttgag atattgttat
    11281 aaaaaatggg tatgtctcca tctattaagt ctgaaaattc gtaatgaact acctttttat
    11341 tcttatatgg ataggcccac atattatgaa gtactttttc tctctctatt gcattagaaa
    11401 agcaattagg atggtatgaa aattccaaca tatcagcata tctttgagtt ggtctgatta
    11461 catttctaac tataagattt tgtaaattat tattaatata tgccaatatt tttttcttag
    11521 aatcctttgc tttcattaaa atacttttca taccagtaac tatatatttt tcatagctga
    11581 taaaactaat tttttcatta ttcataattg gagtattttt tgcagtatcc ataatgtgtg
    11641 tttgatattc aaaacgcatt tcatcagtaa atgtattttt aatttttaat atcttgaacg
    11701 gtacgctttg ctctttaaag tttaacgcac taaggttaac cccttcatct ttcgaatctg
    11761 acttatcttt catcgctaaa tatggtacta gccctgtcac cattatagaa tctaaatatt
    11821 tatatttagc atctactgtt gcgctattac caaactctat aggaatattt tgttgaaaaa
    11881 aagtttcgtt atctatgata acagggtatt ctccatgagc gattatattc tcatagtgta
    11941 agtctgttac attaaataag aaagctattc cgattagttt accatacctt tcataatatt
    12001 tttttacttc ttctatgtta tttatttcta tattatctat atattcttca tagaaatagg
    12061 tatttctagt aactttttta actatataaa tatctgcctc taattcttta tttaaaaatt
    12121 caaaaaaatc tcttaattta ttctcgctat taatctttgg cttgtatact atcttctttc
    12181 catcagaaaa agttagtgta gaaacagttt ttccgcgact atgagagtct ccctgtgatt
    12241 ctgatataga gttaagctct gaggattgta tgttaaaaca attttgtatg ctaggtaaat
    12301 cttcagtcac tcttataagc atttgtttag tattatctaa aaaatatctc attctaacaa
    12361 cagtaatacg catcaactca ggatagcatg tataaaaagc tattatatct tttttagagt
    12421 taaatctttt ttttagataa tagataaatc gcttgctact atcatttccc tttagaggtt
    12481 catttttttt aaaagtatgc aaatctagca ctaatgtttt acttgtcaag tgaataagct
    12541 cttgtgttag attttctaat aaattaataa tgaattcttt tgtacaaata tttaactctg
    12601 agtttaaatc aagtaaaaat aaacgagcat attgtaagaa atatctaaaa ggataactag
    12661 catctacttc taataattgc tcttcactat cattataaga atctaaaatg gattcaaaaa
    12721 aaatatacca tgattgatct ttaatgtatt gaattgcaac ttctttatca ggaaagtttt
    12781 caataggtgt tattcctaat ccaaaattat ccagtgattc atatttatat ttaatcaagt
    12841 agtctaaatc atcttgttta agaacacttt ttctttcttt ccaagcttgt aaatttttaa
    12901 tgtcgtactt ctcgttacca ctttgcttta gtaaaaagca tctttcattt atgcttaaaa
    12961 catttattaa attatcttcc atgtaagcac tcctttttta tgtataagag ggctagtttc
    13021 actagccctc ttaatatata aattagcaaa atttagctga aaataatgca cctactccta
    13081 agcctatggt aaaacatgct ggagttgtct cagcctgaac atctccacta ccttgaatcg
    13141 cttccatttc ttctaaactt aactcttcaa aagaaggacc aacaagttct aatttattag
    13201 agtaatagtt ttcttgattt tccttattta gcactgtgct tcacctcact aagttttata
    13261 gtatatttta acaatgtttt aaagacacaa ctacagttac tccagtaaaa ataccgccac
    13321 caacccagcc acaagcagca ctacttgctg cagctgtcgc cgcaacagca cacaccggtg
    13381 ttgtctcagc ctgaacatct ccactacctt gaatcgcttc catttcctca acacttagtt
    13441 cttcaaaact aggaactaca cttaaatttt ccataattct taccctccat cataaaattg
    13501 ttgtatattg cataacataa tatgttacaa tttaatatta tagagctttt aatcttttgt
    13561 caagtgtcac ttgacaaaaa ggaggaacca aaatggctat ttttattttt ttattggata
    13621 tcatttctgt agtctacttt gtttttaatc tgactgattc aaaaaaagat gagcgaattt
    13681 tatatacaat ttccttaaca tctacttaca tgtacttatt tattaacttt tccatactta
    13741 tagtagttgc tatttttctt tttctaccta atgttattac taaaaactat ctctttaatt
    13801 ttgtctacta ttacttctct ctatcaatga tattgcactc tctgttacta ctttttttca
    13861 acaagaggac ttcataaatg ataatcaata acttaaaatt aattagagag aaaaaaaaaa
    13921 ttagccaaag tgaattagct gctttattag aagttagcag acaaactatt aatggtatag
    13981 aaaaaaataa atataaccct tctttacagt tagcattaaa aattgcttac tacctgaata
    14041 ctccactaga agatattttt caatggcaac ctgaataaaa aagattttta aatttcacca
    14101 cagaatattt aaattaaaag aaaggtgctt cgtatgaaga aaaagtttat atcccttctg
    14161 attttatttt taggaataat tgttggcata gtaacagttt atattttaaa gcataaataa
    14221 ttatgactgt tgttttatac tttaatcata actgattttt tatcagtaaa accctcactt
    14281 atgattacat tcatttaaat aaaaactagg ctcaaatgta tagtaaagac tatctctttt
    14341 tggggggaga cagtctctaa ggttataact tattttagcc tttcatttct aacgcatact
    14401 catagaacta aatgattgat taattcagtc tgtaagaaaa tagttaaatc tgaagtgact
    14461 tgtaattatt ctacagtata cacactgtcc tttcaacaac tgtcgaaagt ttagcaaaac
    14521 attttacaat atttttgtat acatcattat taataataga gccaatacca gaaaatatcc
    14581 gaatagcact ttaaaggttc tactttggtt attttcaggt agctgactta ttaaatagac
    14641 acctgacatc attataagaa cataagtgaa atagtaagtc cttgatccag atacccatat
    14701 ggtaggagag aaccccatca taatacgact tcctacaccc aaaataagaa gaaagataac
    14761 tgataaaaat tctaagggat tattacttgc cccaaaaatc cctattacat aaagaaaaac
    14821 caacccagta agaagaacta ctagtgacat atatgttttt cctgaaacta tatcataagt
    14881 ttgatcaata atcgtattaa atcttgtaca aatcaaatac gtcaatagcg gtattccact
    14941 aatcatcttt ttgactaatg tcccattttt tactagtcca gcagtaagaa ttagcaatac
    15001 aaaagctaac atcaatggag accactcaaa aaataaagct ttcaaagtgg acgaataccc
    15061 tatttgtaac ttatcaaaaa tactgtagct agaaaaatta ggtaaccatt gtttcgtttc
    15121 ttggacgttt cttgccgcat ttcccttaca tgttaaaata aacacaaagc tagcgattac
    15181 aatagcaata tgaggtaaag ttatcaggat attcttttta gacaaaaata gaatacccgc
    15241 taaaattaat aaagaaacta acataatgac taccatttgt tcttgatttg tagcataaat
    15301 caagaacacc aacgataaaa taagagatag ccaatttaca ctttttcctc ttatatagtt
    15361 cataataggc caaatactta acaacgctgc tgccatgacc caaacataat ttgttgttgt
    15421 tgctatccat cctgcattat ttatcatcga agcaggaatt aataatgaca tgcccgtacc
    15481 tataattaat cctcttcgac tattatctga gttaaacagt agtgcaggga caattgccac
    15541 tatagacatt gctatagcat ttaaaactct ccacaaaaat acgtgttgta ccgcttgtgt
    15601 tagagctatt tcaatcacta atcgagacgt ccattcattg tacctaaact ccaaaaattc
    15661 ataatagtta ctttgaaaat catgtgtaaa ctgctttaag aaaaacgcat cgtccccaaa
    15721 ttccatttgt ttaataccaa aattgtaaat taacattacc acaaatacaa aactactgag
    15781 aattaaaata tctctctttt ccactttatt tatcactatg tcactcctat cctccatttt
    15841 tttcaaggac atgcgcttta taaatactat cgatactaga cattggaagc ttttctaatt
    15901 cttcatacgt aaagtcacta ttacgtacaa tcaatattat tttttcttct ttagtcattg
    15961 ctactccctc actttcattg ttctatcgat ttggcttgta ccctcttcat aattgaacac
    16021 gacgtttggc tgcacattat attcataaac attgaaattc agtgtacccg cactgtcaat
    16081 cgcttgtaac caataacctc gaggcattaa ttcctttcca cgaaaaactg tcacgatctg
    16141 ataaatgact ttgttcccct taagcttttg tgcatctctg actagtttct catagtgcgt
    16201 ctgcactttt tgattagaaa aagctgtttg tgttgccagg tttttgggat tgtcttggct
    16261 tccattttca cctatcttaa agtttccgtc aatatcaaag ttaaagctgg acgtataggc
    16321 aagtaaatgt ccgcgattca caatcggatc tccatcgatc tgtttttggt gccaaccagt
    16381 cggttgccag acttgccgtt ctcgtccttc agaacgtcct aaattcttcc tatcaaggta
    16441 ggcagtcaca aatgttgtcc ggttcaaaga atctaagtct ccataaatca ctttgttttc
    16501 tttccacgtg gcaatatcta aactagattg tccgttattg acctctatag cggcttttcc
    16561 gccactttga aagtctaggt tagctaattg attatattgt tgttgatcgt atggcgcact
    16621 tgtggatttc tttgttttta catttcttgg tttctttgta agtgactttt tatctgattt
    16681 cgccacttct tgaaagatat cattagataa aaaagacgag agctgctctg ataagtctaa
    16741 atgattcaac aatccaaaac caattatcac caaggacaat agactaccta accaataggg
    16801 ctgttttttt cttttaactt tcatcgtatt tgtcctcatc ttgactgaat aatgtatcta
    16861 tatcaaagtt ttcatagaac ttgattgttt cttgaaattc ttcctcagtt aatcgatctg
    16921 ttggtttatg atgaaatttt gcacttgagt gaatcccgta aacctttgct agtgtttgaa
    16981 aaagttcgcc ataagtacgt gttttaggga tacgatcgta tgttactttt tgcgcaatat
    17041 cggtaacgac taaatcatga ccgaatccac caaatacttc ttggtattca aaatggtatg
    17101 ctggatataa actgttcaat tcattaatag cagatttcac atcttctgct agatagttat
    17161 ccaaacaaaa gcgttgttta atggcgtctg attgcgccat tttttctatt atggaaaatt
    17221 ctgttaaaag ttgttgtgcc gttacttctc tcatttgttt ttgtcctttc gattattttt
    17281 atcagtgagt ggggcaataa ctgttccttc taacgcacgt tcccgttttg tttgcttttc
    17341 tcggcgttgt ttcaaacttt cttgatactt tttgcttaat tctttattag acatttttcg
    17401 cttctccttt acaattccta agagtagaaa ttttctactc ttaggaaccc ttttgattta
    17461 gttgttttta ctctgcatat aaaacttttc gtccgtagct aatttgctta attttttgta
    17521 aatcaatagc ttcacgcgtc aatgtatcat aggcgtcacg ttcctttttg ttggtaatat
    17581 cgtaactcga gaagtaatca cgactgctat ctatgatgtt tctcatcttg aatgtcagtt
    17641 ccttatcgga aatttggtac gtcaccgtaa tggttttcat tcctttattc tgcactgctt
    17701 gaataatttc cttttctttt tggaattgtt tattctctgc taattctttt gcatactgtt
    17761 gttggaactg tagtttttgt aagtgttcag acaacatcct tgcgtttttc tctaaatatt
    17821 tttttactaa tcgtgattgt gtagcttgtt tctccgttag taagtctaat atctcactgt
    17881 ctgcgcattc gtactgaaca aacgaatgat ccataatgaa cgtagtttgc ccatcgagta
    17941 gtttttttcg cacttcattt tttagtgttg ttattttcca gtctgataag tccgctagat
    18001 actttccttc cagtgtgtaa tagtagttgt agtgttgatt gatttcagca agcgtttgtt
    18061 ctgccagttc tctttccagc tgttgaatca cttcgtgaag atctttaaaa cctgttatat
    18121 ctacaccctt taaatgccat tcaatcaaat actctgcttg tgaaaagaat gtatctgtca
    18181 cgctgtcata tatgccgata acgtctccta ttgactcatt ttgccgaaag gaaagggact
    18241 ctccgtcctg taaaaaggga ttcaaaaaga cggagaaaaa gcgggtactt ttcgggtcga
    18301 tcattatctt aaccagcgac tttgtctgtt tttcctcttg aaaaataaag gtttgttggc
    18361 tgctacataa aaagtcatga aatacttcgg ttgttagtgt cataattctt acctgctttc
    18421 tctttttgat ttttttttgt acttgtcaaa gaaacgtagg taagttatac ttaaaatcta
    18481 taatttgtta aatataacta cctttttaga aatcttttgt cgtaagcaaa aggtttcttt
    18541 ttttttactt ttcaagggcg ttcttccgat attcttccca tgcttttcca taaatggtat
    18601 agagttcgtg ccaatctctg ttcattaatg ccaacatttg ctctaattct tcgttatcct
    18661 ccgagcggat actctcgttc tctagttttt ccatggcgta aacaagtgaa tctaatgtct
    18721 gaaaggcttg ttctttgttc atttggtttt ccttctttcg gttttgattt ttgaacaacc
    18781 atttttgtta ggcgtttgag gaagtgaagc tggacggtca aaaatttctt ttcgtcaaac
    18841 ggtgtagtct cccccctttt tcgttttcga ttaggttgtt cattttcgcc agtgtgttcg
    18901 tgtcgttcgc tgtgccgaga aaggaccgta gacataaaga aaaaacaagg gcgagcttgc
    18961 tcgtttatat acccttgttt tttcgactgg ctatggtact gtaacaaaca gtgaacagca
    19021 cgttacacac ggcaaaagga acggcctgaa aacgaaaaag gctgcgtgac accgttctga
    19081 catcagaaaa gaaatttttg accggaatgt tcttgacctt tgccttgtga aacaaggctt
    19141 tcttccgaac ggcggtggcg gttggagtaa ggaagaaaca gctcttttct cttgattctt
    19201 ctttatgtaa aaagccttgt attgcaagca atacaaggct ttttatgcta taatagaatt
    19261 gatagtaaag tttaatgacg gtggctatcc aatcgaaagt gaggtggtgc gtatgaacgt
    19321 acttccaaaa tctatagaaa ggagaagcct tttgtccgtt tcggaaagtt tgcaactaat
    19381 gcttgcgttt ggtgggttta cattgaccct aatcacaacc attgttgcca ttctgaacta
    19441 taaagacaaa aagaaataac cgtcacttta gcaggagacc ggttatttct aaataactta
    19501 taaaaactct gccactgtct ttagcggtgc tatcaatgag ggcgtattac cagtacgtcc
    19561 tctttacata attattatac cacattttgt gcgaaaaggt aggcgaatgc ctaccttttt
    19621 tcatgcgcgc ctaaacggcg gtggcggttg gagtgtggcg cgcatgaaaa aacagatcta
    19681 ttgattgtag ccatattcag acaacccgtt catggacggt tgttggtaga cattttgttg
    19741 tgtaggtgct tgattcattg ctggttgttc attaaccgtt ggggttgatt gtccttgtgg
    19801 gactgcgtgt tgtttttctt ctcgtttttg tacggtttct ttggactcta aaaactcaaa
    19861 atcttctaca actaattctg tcacataatg cgtaacgcct tgttggtcat catacgaacg
    19921 agtttgtagt tccccattta caccaactaa tgcgcctttt tgcgtgtatt ttgcaaagac
    19981 ttgggcgggt ttgccccata aaacacattg aataaatgtg gtcggcacat ttccgttagt
    20041 gtctggtctt tttcgcttac aagccaatgt aacgtttgcg acactctttc cgttagtggt
    20101 gatacgtagt tcggctcctt ttgttaaacg cccgacagct gataattgaa tcatgattgt
    20161 ttccttcttt ctgatttttt atttatatca tgcctttttt agtggcaata aatatcttgt
    20221 taagtggaag ttttttgaaa tgagagtgat ttgcctgtct aggcaaatca cctccttcta
    20281 tctgccatgc ccttatgagg gcatggcttt ttcaatctct atttgccatt gttcaatggc
    20341 ttcttctact tcttctggta tgtgtccccg attgtatttc ccttgcactt gtatcactct
    20401 tttttcacgg tattctaagg taaaatatgg tttatctggt tcttcttttc ttcggataaa
    20461 aacaatcgtt gtttttcctt ttgtatgttg ttcaaggtaa tgttggctac caacacaatg
    20521 gtgcaatacc tgaccttcct ccacaatttc ttgcaacgaa tgtggggcga gaaaaagtaa
    20581 gtcgtcaatt tcggtttcta atgctttcag ttgttttttt cgttcttggt attgctgttc
    20641 ttcaagctct ctttcaagta aattcaacgt atttgtggca ttgtcatggg ctagttgcaa
    20701 gttttcaggg aaaagcacat catcagtaaa tggtgtattc agttcctcca gcatgtgtaa
    20761 atagtccata tagtagctaa aacgctcgcc ttttcgcata aaccagtgtt gaaacttggt
    20821 taagttcact tctttaggta attgcttaat ttgtgaataa tgtaaataat tttcaattcc
    20881 ttctattctc gcaacttttc gctccttcaa agttttttct agcataagca tatgaaacgt
    20941 tgggttggtg gtttttagtc gctttttatt ggcttttagc cagttcttag taataactct
    21001 catgtctact tttttatgcc atgtgccaaa aatattgcgt tcatcatcaa aaagtatttc
    21061 gtttgccagt gtcgttgcac ctattttttg taaaaattca atttcattgc ggtatttata
    21121 aacatgcgcc agttcttggc gactaattgt aggtagcttg aggtatttca attccgaaat
    21181 ggtcgttagt ttttcttgcc agttatttga atagaaaaca gtgttcgtgt aagcactact
    21241 catgtaacca taatttgcta acaagccctc atgccagtgt ccgttttcat aatgtgcttt
    21301 aacatgggta tcatttgaaa accgttcaag gtttgacggc tcatagataa gggtttctgt
    21361 tccatctgta atcgtctgcc aataactatg ggtttgaatt tcaattcgtt ttgcacgaac
    21421 gagaatgatt ccaaaggagt aaaatttcgt tggaaacgat aatcgtgagt atttcgttaa
    21481 tcgttttttt atggtggggc aattcttgcg agaactcgca agaattgtct cctttttgtt
    21541 ttgccattca tacgttggta tttgtgcagt acaccagtta aaaaaggctt tgggtggggt
    21601 taatggtttt ggtgtttttt tattcatacg cactcgaaca aatcaatttg ttcgtccacc
    21661 tcttttcttt caggttttgt ttctgatttt ttggtcggtt tctttttgtt tgtggtcgtt
    21721 actttaccaa ctgctttggt ttctggtaat ttctctaata agaaatactc ttttatccaa
    21781 ctgaaaacca cttcgtccgc caccatggcg cttgattggt ctttggattg ttcttgggct
    21841 tttcctatgc agtaagtcat agcacctttt aacgttctat cttctttgag aatacctaga
    21901 aaaagcgctt cgtctgtttg tcggcataac cagttatgaa caacttctag tgtactgtca
    21961 tggtcggttt ctagttcttt taacattttc tcaaaagctt gttcttgcgt gctttcttga
    22021 gctgtaaaga aaaatcgttc gtaagaattt ttgtcgctaa tcactagcca ttggtagttg
    22081 tttccttggt ctatcgtttc gtcaattgtt agaaaaagtg acgagtagtt accgtcatgg
    22141 tctttaatcg taacgattgc ttgttcaggt aacttttcaa ggtaagccag taacgtttct
    22201 actggataaa gagctacctc ataatttgga taaaaacata aaaactgaac gttttttccg
    22261 tctttttcta tcacttcttt tttaaaggcg acactgatat agccttgtgt atcatcaaaa
    22321 atcgtagttg cgagtgtttg tttgtattgt ttcagtgcgt atcttaattc ttttacagtt
    22381 tgtatatttt gaaagtccat aacgtttcct catttcttgt aagcttcccc tcttaaaatt
    22441 taagagggga gcaaattttc acttgtcaaa ggtcgttagg taagttatac ttgagttaca
    22501 attaattcaa gtgtaagtac ctttttagaa atcttttgtc gttagcaaaa ggtttctttt
    22561 tttatagtaa atttttaagt tttccattgt taatttccca ctcgtaccat tctgtaaaat
    22621 cttgagggaa accattgacc gcatattttg cttgttcttt ggcttcttct tcgttgattg
    22681 ggtcaagggc tgtcggtttg tcttttggtc gtgcataaca gcctatccat gtttcaaagt
    22741 cgccctcaaa gcaaccgtca ataatcaatc cccattcgtt taattctgtt cttgcttgtt
    22801 cttttagttc ttcaattctg tttctcatat actttcagtc cttccattct ttatgattta
    22861 gaaaatattc tagttgatat aaacggtcat tcgcattttt caaacaacta taattaagta
    22921 gtaacgtcac tgtgtcattt gtgataatgg cttcacttaa tttctggtgt tcttttctgg
    22981 ca
//
